Scale-space segmentation

Scale-space segmentation or multi-scale segmentation is a general framework for signal and image segmentation, based on the computation of image descriptors at multiple scales of smoothing. 
One-dimensional hierarchical signal segmentation.
Witkin's seminal work in scale space included the notion that a one-dimensional signal could be unambiguously segmented into regions, with one scale parameter controlling the scale of segmentation. 
A key observation is that the zero-crossings of the second derivatives (minima and maxima of the first derivative or slope) of multi-scale-smoothed versions of a signal form a nesting tree, which defines hierarchical relations between segments at different scales. Specifically, slope extrema at coarse scales can be traced back to corresponding features at fine scales. When a slope maximum and slope minimum annihilate each other at a larger scale, the three segments that they separated merge into one segment, thus defining the hierarchy of segments.
Image segmentation and primal sketch.
There have been numerous research works in this area, out of which a few have now reached a state where they can be applied either with interactive manual intervention (usually with application to medical imaging) or fully automatically. The following is a brief overview of some of the main research ideas that current approaches are based upon.
The nesting structure that Witkin described is, however, specific for one-dimensional signals and does not trivially transfer to higher-dimensional images. Nevertheless, this general idea has inspired several other authors to investigate coarse-to-fine schemes for image segmentation. Koenderink proposed to study how iso-intensity contours evolve over scales and this approach was investigated in more detail by Lifshitz and Pizer. Unfortunately, however, the intensity of image features changes over scales, which implies that it is hard to trace coarse-scale image features to finer scales using iso-intensity information. 
Lindeberg studied the problem of linking local extrema and saddle points over scales, and proposed an image representation called "the scale-space primal sketch" which makes explicit the relations between structures at different scales, and also makes explicit which image features are stable over large ranges of scale including locally appropriate scales for those. Bergholm proposed to detect edges at coarse scales in scale-space and then trace them back to finer scales with manual choice of both the coarse detection scale and the fine localization scale. 
Gauch and Pizer studied the complementary problem of ridges and valleys at multiple scales and developed a tool for interactive image segmentation based on multi-scale watersheds. The use of multi-scale watershed with application to the gradient map has also been investigated by Olsen and Nielsen and has been carried over to clinical use by Dam et al. Vincken et al. proposed a hyperstack for defining probabilistic relations between image structures at different scales. The use of stable image structures over scales has been furthered by Ahuja and his co-workers into a fully automated system. A fully automatic brain segmentation algorithm based on closely related ideas of multi-scale watersheds has been presented by Undeman and Lindeberg and been extensively tested in brain databases.
These ideas for multi-scale image segmentation by linking image structures over scales have also been picked up by Florack and Kuijper. Bijaoui and Rué associate structures detected in scale-space above a minimum noise threshold into an object tree which spans multiple scales and corresponds to a kind of feature in the original signal. Extracted features are accurately reconstructed using an iterative conjugate gradient matrix method.
Segmentation of vector functions of time.
Scale-space segmentation was extended in another direction by Lyon to vector-valued functions of time, where the vector derivative does not have maxima and minima, and the second derivative does not have zero crossings, by putting segment boundaries instead at maxima of the Euclidean magnitude of the vector derivative of the smoothed vector signals. This technique has been applied to segmentation of speech and of text. 