U.S. Route 52 in Virginia

U.S. Route 52 (US 52) in Virginia runs north–south through the southwestern part of the state along the Interstate 77 (I-77) corridor. Though an even-numbered U.S. route, it is signed north–south in Virginia (standard convention being to label even-numbered U.S. routes with east–west designations). In some other states along its route, it is signed east–west. The Virginia segment is signed such that US 52 north corresponds to the general westward direction of the highway, and "vice versa".
Route description.
US 52 enters Virginia from West Virginia, and in Virginia closely follows I-77. It enters southwestern Virginia near Bluefield and passes through Wytheville and Hillsville before leaving the state south of Cana.
History.
The piece of US 52 south of Fort Chiswell was part of the state highway system defined in 1918. It was initially designated State Route 12-Z, at least south of Hillsville, but by 1924 it was State Route 15. In 1926, the U.S. Route 121 designation was applied to the whole length of SR 15, from North Carolina to Fort Chiswell, but it did not turn west on U.S. Route 11 at Fort Chiswell to connect to U.S. Route 21.
An extension of SR 15 from Fort Chiswell north to Max Meadows was added to the state highway system in 1931. In the 1933 renumbering, SR 15 was dropped from the US 121 concurrency, while the short extension to Max Meadows became State Route 121.
US 121 was absorbed by an extension of US 52 by 1935. US 52 was extended through West Virginia and along US 21 to Wytheville and US 11 to Fort Chiswell, where it replaced US 121 into North Carolina.