Nakon više od jedne decenije u opoziciji, Karamanlisova konzervativna stranka Nova demokratija (ND) došla je na vlast nakon parlamentarnih izbora u martu 2004, u kojima je osvojila glatku pobjedu nad Panhelenskim socijalističkim poketom (PASOK).
After more than a decade in opposition, Karamanlis' conservative New Democracy (ND) party came to power following the March 2004 parliamentary elections, in which it won a landslide victory over the Panhellenic Socialist Movement (PASOK).