Karadžić, koji je vršio i formalnu i stvarnu vlast i kontrolu nad snagama bosanskih Srba i nad svim organima SDS-a i vlade, optužen je i u vezi s ubistvom iz jula 1995. i do 8.000 muškaraca i dječaka, bosanskih Muslimana, zarobljenih na nekoliko različitih lokacija u i oko "bezbjedne zone" UN-a Srebrenice.
Karadzic, who exercised both formal and de facto power and control over the Bosnian Serb forces and all SDS and government authorities, was also indicted in connection with the July 1995 killings of up to 8,000 Bosnian Muslim men and boys, captured in several different locations in and around the UN designated "safe area" of Srebrenica.