CEI sarađuje s međunarodnim organizacijama i institucijama, poput Organizacije za ekonomsku saradnju i razvoj, Vijeća Evrope, OSCE-a, Evropske banke za obnovu i razvoj i Svjetske banke, te s različitim regionalnim strukturama, poput Jadransko-jonske inicijative, Procesa dunavske saradnje i Pakta stabilnosti.
The CEI co-operates with international organisations and institutions such as the Organisation for Economic Co-operation and Development, the Council of Europe, the OSCE, the European Bank for Reconstruction and Development and the World Bank, and different regional structures, such as the Adriatic-Ionian Initiative, the Danube Co-operation Process and the Stability Pact.