37-year-old female with known right triple negative breast cancer and metastatic right axillary lymphadenopathy. She presents for I-SPY 2 research MRI #3. There is heterogeneous amount of fibroglandular tissue in both breasts. Mild background parenchymal enhancement is noted bilaterally.RIGHT BREAST:The index malignancy at upper outer quadrant shows a significant reduction of its size. Although the index mass measured 3.0 x 2.2 x 1.9 cm on the prior study, there are only two enhancing foci remaining at the site of prior index mass. Multiple additional enhancing masses are still present, but they become significantly smaller. Total extent of these lesions is 5.0 x 1.7 x 3.7 cm (previously 5.8 x 2.7 x 5.2 cm).In the right axilla, the proven metastatic lymph node with marker clip measures 1.3 cm (previously 1.7 cm). No other abnormal lymph nodes are seen.LEFT BREAST:A stable oval circumscribed mass, which is biopsy proven to be benign, is again seen in the retroareolar region. No abnormal enhancement seen elsewhere in the left breast. No abnormal axillary lymph nodes are identified in the left axillary region.
1. Significant reduction in the size of the index mass and additional multiple masses in the right breast.2. Interval reduction in the size of metastatic right axillary lymph node3. No MRI evidence of malignancy in the left breast. BIRADS: 6 - Known cancer.RECOMMENDATION: X - No Letter.