Female, 45 years old, right-handed with left frontal lobe cortical lesion. Memory and speech problems. Motor paradigms elicited activation in the expected motor and sensory cortex of the pre- and post-central gyri. All tested language paradigms produced reliable language related activity. Language is left dominant, but with moderate contributions from the right hemisphere.Language paradigms elicit putative Broca's area activity in the left frontal pars triangularis. These foci of activity are medial and anterior to the patient's left opercular lesion. Notably, there is also a small focus of activation seen on two out of four language paragidms within the lesion itself. Language paradigms elicit putative Wernicke's area activity in the left superior temporal sulcus region. Secondary language activity is seen in the left greater than right middle frontal gyri. Language related SMA activity is also seen.
1.Functional MRI with motor and language paradigms showing activation of the usual expected areas as described above. Language is left dominant but with moderate contributions from the right hemisphere.2.Robust putative Broca's area activation is seen in the left pars triangularis. This activity is anterior and medial to the patient's opercular lesion. Note is made, however, of a small focus of activity within the lesion itself elicited by two different language paradigms. This activation is of uncertain etiology, and may represent a minor contribution to Broca's area processing, or perhaps just secondary language activation.