45-year-old female with multiple sclerosis. Since the MRI exam from 2005, there has been progression of the predominately supratentorial periventricular and subcortical Flair hyperintense signal. The majority of the signal abnormality is hypointense on T1 but there are multifocal areas of enhancement indicating active demyelinating disease. There is no evidence of intracranial hemorrhage or acute infarct. The ventricles and basal cisterns are stable in size and configuration. There is no midline shift or herniation. The major cerebral flow voids are intact. The orbits, skull, paranasal sinuses, and scalp soft tissues are grossly unremarkable.
Interval progression of the periventricular and subcortical predominant white matter demyelinating lesions with multifocal areas of enhancement indicating active disease. 