Female, 29 years old, with multiple sclerosis and gait problems, follow-up progression. Numerous T2 hyperintense lesions are evident involving the corpus callosum, the periventricular and juxtacortical white matter of the cerebral hemispheres, brainstem and cerebellum. Since the prior examination, numerous lesions have increased in size or have newly developed. The largest progressive lesion is evident in the right frontal juxtacortical white matter and shows marked corresponding T1 hypointensity. The remaining lesions demonstrate mild to moderate T1 hypointensity. No evidence of significant generalized mass effect is seen. Brain parenchymal volume is relatively preserved. No abnormal extra-axial fluid collections are seen. The ventricles remain normal in size and morphology. A mucous retention cyst seen in left maxillary sinus.
Progression of demyelinating disease in the brain.