Research scan for AMARANTH Alzheimer's disease trial: Memory decline. There is mild cerebral volume loss that is most pronounced in the bilateral medial temporal lobes. There is extensive cerebral and pontine white matter T2 hyperintensity bilaterally. There is no midline shift or evidence of intracranial mass lesions. There are bilateral lens implants.
1. Mild cerebral volume loss that is most pronounced in the bilateral medial temporal lobes may represent Alzheimer's disease.2. Extensive cerebral and pontine white matter T2 hyperintensity bilaterally is nonspecific, but may represent chronic small vessel ischemia.