25 year old female with a history of doxorubicin exposure as a child and new development of LV dysfunction. Referred for cardiovascular MRI to evaluate cardiomyopathy for infiltration, inflammation, or scar. Left VentricleThe left ventricle is severely dilated with severely reduced systolic function. There is global dilation and hypokinesis. The overall LV ejection fraction is 28%, the LV end diastolic volume index is 146 ml/m2 (normal range: 65+/-11), the LVEDV is 262 ml (normal range 109+/-23), the LV end systolic volume index is 106 ml/m2 (normal range 18+/-5), the LVESV is 190 ml (normal range 31+/-10), the LV mass index is 52 g/m2 (normal range 67+/-11), and the LV mass is 94 g (normal range 114+/-24). There is no late gadolinium enhancement to suggest the presence of an underlying fibrosing, infiltrative, or inflammatory process.No intracardiac thrombus.Left AtriumThe left atrium is severely dilated. Right VentricleThe right ventricle is normal in size with mildly reduced systolic function. The overall RV ejection fraction is 48%, the RV end diastolic volume index is 94 ml/m2 (normal range 69+/-14), the RVEDV is 469 ml (normal range 110+/-24), the RV end systolic volume index is 50 ml/m2 (normal range 22+/-8), and the RVESV is 89 ml (normal range 35+/-13). Right AtriumThe right atrium is normal in size. Aortic ValveThe aortic valve is mildly thickened and there is no significant aortic regurgitation or stenosis.Mitral ValveThe mitral valve is mildly thickened and there is mild mitral regurgitation.Pulmonic ValveThe pulmonic valve opens widely. There is no significant pulmonic regurgitation.Tricuspid ValveThe tricuspid valve opens widely. There is no significant tricuspid regurgitation.AortaThere is a left sided aortic arch with a normal brachiocephalic branching pattern. The aortic root is normal in size.Pulmonary VeinsAll four pulmonary veins drain normally into the left atrium.Pulmonary ArteryThe main pulmonary artery is normal in size. Venous AnatomyThe SVC and IVC are normal in size and drain normally into the right atrium. PericardiumThere is no pericardial disease.Extracardiac FindingsSmall cyst noted in the superior pole of the right and left kidneys.
1. Left ventricle is severely dilated with severely reduced systolic function (LVEF 28%). There is no late gadolinium enhancement to suggest the presence of an underlying fibrosing, infiltrative, or inflammatory process.2. Right ventricle is normal in size with mildly reduced systolic function (RVEF 48%)3. Mildly thickened mitral valve with mild regurgitation.4. Mild thickening of the aortic valve leaflets. 