Progressive supranuclear palsy clinical trial, principal investigator Dr Tao Xie. The FLAIR images are degraded by motion. There is atrophy of the midbrain. There also appears to be mild atrophy of the cerebellar vermis. There is no evidence of intracranial hemorrhage. There are minimal confluent and punctate foci of T2 hyperintensity within the supratentorial white matter. The ventricles and basal cisterns are normal in size and configuration. There is no midline shift or herniation. The major cerebral flow voids are intact. The orbits, skull, paranasal sinuses, and scalp soft tissues are grossly unremarkable. There appears to be congenital narrowing of the imaged portions of the cervical spinal canal.
1.Atrophy of the midbrain is compatible with progressive supranuclear palsy.2.Nonspecific supratentorial white matter signal abnormality is nonspecific, but may represent chronic small vessel ischemic disease.I personally reviewed the Images and/or procedure with the Resident/Fellow and agree with this report.