Multiple Sclerosis on Tysabri for 15 months. Several sequences are motion degraded.BRAIN: There are multiple T2 hyperintense lesions in the periventricular and subcortical white matter, which have not significantly changed in number or size. Many of the lesions demonstrate T1 hypointensity. There are no enhancing lesions. There is no evidence of intracranial mass or mass effect. The ventricles and basal cisterns are normal in size and configuration. There is no midline shift or herniation. The skull and extracranial soft tissues are unremarkable. CERVICAL SPINE: There are multiple stable small demyelinating plaques primarily in the upper cervical spine without abnormal enhancement or interval progression since the prior study. The vertebral column alignment is within normal limits. The vertebral body and disc space heights are preserved. The vertebral bone marrow signal is unremarkable. There is no significant spinal canal stenosis. The paravertebral soft tissues are unremarkable.THORACIC SPINE: There are several T2 hyperintense lesions in the thoracic cord from T8 to T12 which are similar to prior examination No new lesions are seen. There is no abnormal enhancement. The vertebral body heights in the thoracic spine are intact and the alignment is normal. There is disc desiccation, small bulge and Schmorl's node at the T9-T10 level. There is no significant spinal canal or neural foraminal stenosis. The paravertebral soft tissues are unremarkable.
1.No significant interval change in the demyelinating lesion in the brain and cervical and thoracic spinal cord.2.No evidence of PML.I personally reviewed the Images and/or procedure with the Resident/Fellow and agree with this report.