31-year-old female with known left triple negative breast cancer and metastatic left axillary lymph node. She presents for I-SPY 2 research MRI #3. There is extreme amount of fibroglandular tissue in both breasts. Moderate background parenchymal enhancement is noted bilaterally.LEFT BREAST:The index malignancy is significantly reduced in size. A small enhancing mass, measuring 9 x 5 x 9 mm, and several enhancing foci are remaining at the location of the index lesion, which measured 26 x 20 x 43 mm on the prior study.Multiple additional enhancing masses were seen antero-inferiorly from this index malignancy on the prior study. Now, all those masses are smaller and have become foci. The largest focus measures 5 mm, and it is located 18 mm medially from Hydromark clip. The total span of enhancement (index lesion + additional satellite lesions) in the AP oblique dimension measures approximately 51 mm, previously measuring 83 mm. In the left axilla, the biopsy proven lymph node with biopsy marker clip now measures 9 mm, previously measuring 16 mm. RIGHT BREAST:Stable enhancing benign-appearing masses in the right breast. There is no new abnormal enhancement seen in the right breast. No abnormal lymph nodes are identified in right axilla.
1. Significant reduction in size of the index cancer and additional masses in the left breast.2. No MRI evidence of malignancy in the right breast.BIRADS: 6 - Known cancer.RECOMMENDATION: X - No Letter.