36 year old with known right breast cancer and metastatic right axillary lymph node presents for research MRI of I-SPY protocol (3rd time point). There is heterogeneous amount of fibroglandular tissue in both breasts.Moderate parenchymal enhancement is noted bilaterally.A known cancer is again identified at posterior depth in the right breast, 11 o'clock position, measuring in total extent 13 x 8 x 9 mm (AP x LR x CC) and previously 18 x 16 x 19 mm. The primary mass now measures 8 x 8 x 9 mm with a small focus of enhancement anterior to the mass which is included in the total extent given above. There has been resolution of the linear non mass enhancement extending inferior and anterior from the known cancer which previously measured 31 x 6 x 8 mm.  An enlarges lymph node is again seen in the right axilla, with maximum diameter of 9 mm (previously 15 mm) . No abnormal enhancement is seen in left breast. No abnormal axillary lymph nodes are identified in left axillary region.
Decrease in size of known cancer in the right breast and metastatic right axillary lymph node as described above.BIRADS: 6 - Known cancer.RECOMMENDATION: X - No Letter.