Male, 20 years old, with history of paranoid schizophrenia. Functional MRI requested for identification of the sensorymotor language area, primary auditory cortex, and area Spt (Sylvian parietotemporal) with external anatomic correlates for transcranial magnetic stimulation. Sensorimotor cortical activation observed during the hand, foot and face/tongue motor tasks maps to its expected locations along the pre- and post-central gyri.Passive auditory stimulation induces cortical activation bilaterally in the superior temporal gyri (Heschl's gyrus and to a small degree the planum temporale).All tested language paradigms produced reliable language related cortical activation. Language is left dominant with task-dependent minor contributions from the right hemisphere.Broca's area cortical activity is identified in the pars opercularis of the left inferior frontal lobe, again with minor contributions from the right. Wernicke's area cortical activity is identified along the posterior aspect of the left superior temporal sulcus, best seen on the verb generation paradigm.A candidate for area Spt is identified only on the verb generation paradigm where cortical activation is present on the left along the Sylvian fissure at the junction of the parietal and temporal lobes.Most language paradigms elicit robust bilateral secondary language activation, particularly in the middle frontal gyri, though again with some left predominance. Language related SMA activation is also seen.
Sensorimotor cortical activity maps as expected along the pre- and post-central gyri.Language is left dominant with some minor task dependent contributions from the right hemisphere. Broca's area is identified as expected in the pars opercularis of the inferior frontal lobe. Wernicke's area is identified as expected along the posterior aspect of the superior temporal sulcus.Passive auditory stimulation identifies primary auditory cortex mapping to the superior temporal gyri (Heschl's gyrus and the planum temporale).A candidate region for area Spt is identified on the verb generation paradigm where cortical activity is seen on the left, along the Sylvian fissure, at the junction of the parietal and temporal lobes. 