50 years, Female, rapidly progressive consolidative decline. Assess for CJD. There is significant restricted diffusion involving the right caudate head and anterior putamen and to a subtle degree involving the left caudate head and anterior putamen. There are also scattered areas of subtle cortical restricted diffusion particularly in the right cerebral hemisphere. There is T2 hyperintensity involving the right caudate head and anterior putamen and to a milder degree on the left.No evidence of infarct, hemorrhage, intracranial mass, or mass effect. Brain parenchymal volume is within normal limits. No hydrocephalus or extra-axial collections. Major flow-voids are preserved. Calvarium and extracranial soft tissues are grossly unremarkable.
Areas of restricted diffusion and T2 hyperintensity in the basal ganglia and cortex, right greater than left. Appearance and distribution of these findings is highly suspicious for Creutzfeldt-Jakob disease.