a built - in and process - adaptive formulation of antimicrobial commodity thermoplastic resins with mixed compositions comprising of a polymer , a backbone linker , and a non - labile antifouling and biocompatible coupling agent which is melt - processable and enabled to be manufactured into finished products in the form of solid , monolith , tube , composite , fiber , film , sheet and varnish without the prerequisite of biocides or antimicrobial additives is disclosed . the said formulation is adapted to thermoforming and thermal curing processes including but not limited to melt compounding , spinning , extrusion , molding , compression foaming and drawing . the antimicrobial property is attributed to the persistent formation of a non - stick bacteria - repellent tethered layer in which the antifouling component of the said formulation is heterogeneously phase separated and / or surface migrated to the surface after product forming in order to minimize adsorption and / or colonization of bacteria .