the present invention refers to new microspheres including pancreatic enzymes , pharmaceutical compositions containing them , and a process to obtain them . the process here described doesn &# 39 ; t involve the use of solvents and proves to be remarkably shorter and efficient than the producing methods of the prior arts . the microspheres obtained , including one or more pancreatic enzymes , one or more hydrophilic low - melting polymers and eventual excipients , have an high enzymatic activity , bio - availability and stability .