this invention provides a novel process of using magnetically responsive fluorescent polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide as highly sensitive quantitative reagents for biochemical and immunological studies , wherein the fluorescent magnetic particles can serve as a marker for the number of particles . a wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles . the surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer . these magnetically responsive fluorescent polymer particles can be used for passive or covalent coupling of biological material such as antigens , antibodies , enzymes or dna / rna hybridization and used as solid phase for various types of immunoassays , dna / rna hybridization probes assays , affinity purification , cell separation and other medical , diagnostic , and industrial applications .