a saponin nano micelle , preparing method , application and pharmaceutical composition thereof is disclosed in the present invention . the saponin nano micelle comprises one or more of saponins represented by formula 1 , in which , r 1 and r 2 are independently — h or a hydrophilic group , r 3 is — h or — oh , r 4 is a lipophilic group . the preparing method of the saponin nano micelle is that mixing the saponin with an organic solvent which can dissolve saponin , and then removing the organic solvent . the saponin micelle acts as a convey medium of the drug ingredients , and can replace conventional drug carriers such as pharmaceutical solubilizers or polymeric micelle , which has high safety and great significance . the pharmaceutical ingredients can prolong circulation time and biological half - life of drug in the blood , and increase the accumulation of drug in lesions , and reduce adverse reactions .