this invention is a heterobifunctional artificial cornea or biomedical membrane and novel process for preparing the heterobifunctional artificial cornea . in this method , plasma induced graft polymerization is adopted to provide the surface property modification of polymer materials like silicone or polyurethane . at first , the frontal side of the material is grafted with polyacrylic acid or polymethacrylic acid and then bonded with collagen , or 2 - hydroxyethylmethacrylate is grafted alone . a surface which increases the cell attachment and growth can be then developed . another side of this membrane is grafted with acrylic acid or polymethacrylic acid and then different molecular weights of polyethylene oxide is bonded thereto . 2 - methacryloyl - oxyethyl phosphoryl chloride is grafted to the membrane . the copolymer of the 2 - methacryl - oyloxyethyl phosphoryl chloride and mpc - co - butyl methacrylate can be used in preparing a special surface which can inhibit the attachments of cells and protein molecules . thus , a heterobi - functional biomedical membrane can be developed . in this work , the surface characterization of this membrane , in vitro study and animal in vivo study are also investigated . the obtained results exhibit a very good performance . moreover , it demonstrates that the developed product has good transparency , hydrophilicity and high biocompatibility , thereby exhibiting the high potential in the application field of artificial cornea .