this invention describes method to facilitate intradermal delivery of a great variety of active substances , especially including high molecular weight cosmicuticals . also disclosed is a method of applying the composition of matter resulting from the method topically to patients , especially using a cream or patch . the active substance is initially combined with a biopolymer , which combination is subsequently linked to a base formulation whereby the base formulation aids in the intra - dermal delivery of the active substance without the skin irritation limitations of other formulations and dermal transmitting methods . the method of using a combination of natural herbal , vegetable and animal products combined in this invention with biopolymers permits molecules of higher molecule weight to penetrate into the skin in a bioactive form by passive delivery means . the invention includes a method for the improvement of skin health and wrinkle reduction .