manufacture of nanoparticles on the basis of methyl vinyl ether and maleic acid for the administration of pharmaceuticals of an hydrophilic nature , in particular analogs of puric and pyrimidinic bases . the nanoparticles are obtained by desolvation with an hydroalcoholic phase of a methyl vinyl ether and maleic acid copolymer solution in acetone . the particles obtained are next treated with cross - linking agents for the purpose of prolonging their useful life and are , possibly , incubated with a pharmaceutical which will be transported on the surface . the nanoparticles can carry the pharmaceutical likewise encapsulated which would then be added during the desolvation . in the case of the nanoparticle - ligand conjugates , the nanoparticles previously obtained and containing inside the pharmaceutical to be transported are incubated with the ligand or molecule which will contribute the property of specifically recognising a particular receptor of the organism . these pharmaceutical forms have as objective to improve the transport of the pharmaceutical or biologically active molecule to its site of action and / or absorption . this property improves the specificity and effectiveness of said pharmaceuticals .