provided are a hybrid of a poorly soluble basic drug and a layered silicate , including a water - soluble basic polymer , and a method of preparing the same . the water - soluble basic polymer may be an aminoalkylmethacrylate copolymer methacrylate , and methyl methacrylate , degussa ) or polyvinylacetal diethylaminoacetate . in an oral formulation including the hybrid , a short - term dissolution of the poorly soluble drug can be increased to 90 %, thereby increasing drug bioavailability .