a biochip comprising a plastic substrate , an ic chip , and a sealing cover is disclosed in this invention . the plastic substrate combines the function of sample inlet area , separating structure , micro - fluidic channel , flow resistor , detection area , and capillary pump or suction area . sealing the plastic substrate with porous cover could make the structure of micro - fluidic to form the capillary effect or degas - driven effect , and drive the sample naturally without extra pump . the detection area is constituted by the ic chip which is embedded into the plastic substrate , and the ic chip includes the amplifier circuit and detection structure . in the detection area , there uses the biological specific conjugates to catch the bio - particles , nano - particles , or macromolecule sensitively . and finally , transfer the detected electric signal to a mobile communication device .