a method of treating blood plasma or fractionated plasma products with fumed colloidal silica to remove fibrinogen without polymerization to fibrin , to remove the plasminogen - plasmin proteolytic enzyme system , to remove cholesterol and lipoproteins and reduce triglycerides , while maintaining plasma coagulation factor ii at pretreatment levels and leaving immunoglobulins and other protein constitutents unaffected , and the resulting product . plasma products treated with fumed silica may be subjected to long - term storage for a year or more without loss of its biologically active support properties , thereby circumventing the problem of hepatitis . the treated plasma products , either fresh or after long - term storage , may be used as a perfusion support media for organ perfusion , for treatment of hemmorrhagic shock and similar purposes for which untreated plasma and fractionated plasma products are customarily used , with equal or superior effectiveness .