this invention describes a composition of matter for to facilitate transdermal delivery of a great variety of active substances , especially including high molecular weight drugs such as insulin . also disclosed is a method of forming the composition of matter and applying topically to patients , especially using a patch . the active substance is initially combined with a biopolymer , which combination is subsequently linked to a base formulation whereby the base formulation aids in the transdermal delivery of the active substance without the skin irritation limitations of other formulations and transdermal methods . the use of a combination of natural herbal , vegetable and animal products combined in this invention with biopolymers permits molecules of higher molecule weight to penetrate the skin in a bioactive form by passive delivery means .