container for sample preparation or processing , such as biomass culturing or processing , and optionally sample purification . in certain embodiments , the reactor is a bioreactor that includes a stirred cell device that simulates a tangential flow filter to reduce or eliminate clogging that can be caused by the solids generated . in certain embodiments , the solids comprise a precipitate or floc or beads , such as one that includes a polymer that binds the biomolecule of interest , and impurities . in its method aspects , embodiments disclosed herein include purification and isolation of biomolecules of interest derived from cell culture fluids . the methods include carrying out sample preparation or processing in a container , culturing a biomass ; generating solids by precipitating or flocculating a biomolecule of interest from the cultured broth ; preventing the solids from settling in the container by agitation ; and purification , such as by eluting the biomolecule of interest and filtering the same .