a method and system of embolizing an organ or vessel is disclosed . an embolization device such as a coil , balloon , spheres , stents or occlusive plaques is used . the embolization device has a surface , which may be coated with composition retaining material such as a polymer , bio - polymer or non - polymer based technology that allows sustained release of drug or material from drug eluting occlusive device . for example , an anti - angiogenic composition is coated on the application surface . the embolization device is then inserted in the vessel and embolization is enhanced by the composition .