this disclosure relates to a method and a system of producing nanoparticles and nanoparticle matrices of thermolabile , biocompatible matrix materials , like lipids and biopolymers with controlled properties . a prototype pulse - heat aerosol system is described for single - step production of free , thermolabile nanoparticles with sufficient control over size , morphology and crystallinity with controlled - release properties , for possible therapeutic , cosmetic or diagnostic use . nanoparticles of the range 50 to 500 nm are obtained and are found suitable for controlled drugs delivery .