a substantially solvent - free molten or fluid desiccant / organic matrix composition is adhered to a package whereby the desiccant is in communication with a compartment of the resulting package such that the compartment is desiccated by the desiccant composition . the desiccant composition preferably contains a thermoplastic organic matrix , is heated before it is adhered to the package , and cools after application . in some instances , the desiccant matrix may be adhered to a component of the package contents . the package is preferably non - reclosable and suitable for holding an article such as a drug , medical device or electronic device .