the present invention relates to the development of a hyaluronic acid and hyaluronic acid hybrid nanoparticle systems for the administration of active molecules , peptides , dna and / or other hydrophilic or hydrophobic molecules , the composition of hyaluronic acid and hyaluronic acid hybrid nanoparticle systems , and the procedure for their development and use . these nanoparticles are made up of hyaluronic acid in salt form , preferentially the sodium salt of the polymers or hybridized with magnetic fe particles . the nanoparticles are basically from natural polymers , biocompatibles and biodegradables . the nanoparticles allow the controlled release of the active molecules they transport and their orientation towards the target tissues . the present invention teaches a procedure to elaborate particles of hyaluronic acid with a diameter less than 180 nm ., that incorporate an active ingredient , independent of its hydrophilic or hydrophobic nature . procedures to produce the particles are described . the present invention will be useful in methods of transdermal drug delivery using hyaluronic acid nanoparticles , among other uses .