this invention herein describes a method of facilitating the entry of drugs into cells and tissues at pharmokinetically useful levels and also a method of targeting drugs to specific organelles within the cell . this polar lipid / drug conjugate targeting invention embodies an advance over other drug targeting methods because through this method , intracellular drug concentrations may reach levels which are orders of magnitude higher than those achieved otherwise . furthermore , it refines the drug delivery process by allowing therapeutic agents to be directed to certain intracellular structures . this technology is appropriate for use with antiproliferative , antibiotic , antimycotic , antiviral and antineoplastic drugs , in particular in combination with a multiplicity of other emollients and agents to make up topically - active substances such as salves , for rapid and efficient introduction of such agents through the epidermis for treatment of skin diseases and other disorders .