a non - invasive injectable composition that contains type i collagen , an osteogenic growth factor , such as a bone morphogenetic protein and a reverse thermo - sensitive biodegradable polymer such as poloxamer 407 in an aqueous vehicle . the formulation can be administered non - invasively , e . g ., by injection , thus circumventing limitations of many currently marketed bone - inducing products . the injectable osteogenic formulation effectively induces bone formation at the desired locale . this injectable suspension could be used with bioresorbable bone mineral composites and / or glycosaminoglycans to mold as putty and / slab as bone graft substitute implants to induce new bone formation in fracture healing and spine fusion procedures .