biodegradable and biocompatible polymeric hydrogels based on the mixtures of poly and poly macromers , and methods for their preparation and use , are disclosed . the polymerization may be carried out in situ on organs or tissues or outside the body . applications for such biocompatible crosslinked hydrogels include prevention of post - operative adhesions , surgical sealants , embolic therapies , controlled delivery of drugs , coating of medical devices such as vascular grafts , wound dressings and other medical applications .