this invention describes a bioerodible fibrin material which is obtained by mixing fibrinogen and thrombin reconstituted or diluted with a particular high tonic strength medium , free of calcium . such a fibrin - based biomaterial develops a tight structure with thin fibers and small pore size suitable for use as an anti - adhesion barrier . in this invention , thrombin is no longer the variable which governs the tightness and the porosity of the fibrin material obtained , but still controls the clotting time . the mechanical behavior , high - water capacity , and releasable retention properties for therapeutic agents of this fibrin structure causes the fibrin material to be ideally suited for use as a drug delivery device , capable of delivering proteins , hormones , enzymes , antibiotics , antineoplastic agents and even cells for local and systemic treatment of human and non - human patients .