this invention provides methods for the preparation of a tissue sealant - treated biomaterial , wherein the tissue sealant used in the method comprises at least one composition which is selected from one or more antibodies , analgesics , anticoagulants , anti - inflammatory compounds , antimicrobial compositions , antiproliferatives , cytokines , cytotoxins , drugs , growth factors , interferons , hormones , lipids , demineralized bone or bone morphogenetic proteins , cartilage inducing factors , oligonucleotides polymers , polysaccharides , polypeptides , protease inhibitors , vasoconstrictors or vasodilators , vitamins , minerals , stabilizers and the like . further provided are the biomaterial prepared therefrom , including vascular grafts .