an alternating copolymer comprising a backbone of residues of a maleic anhydride derivative and those of a compound containing vinylic unsaturation , which also comprises residues of an active compound containing a nucleophilic group , bound to the backbone by a residue of the nucleophilic group , including such a copolymer comprising residues of an active compound containing an alcohol , thiol or amine group . the chemical and biological properties of actives , such as protease inhibitors , neurotransmitter drugs , and other small molecule active drugs , are enhanced , and new applications enabled . also , artefacts , including a solid medical implant device , dressing or scaffold or a fluid adhesive or medicinal composition comprising such a polymer , and a method of use of such a polymer , including a method for the treatment or prophylaxis of wounds .