the present invention relates to a hot melt extrusion composition , a process for preparing a hot melt extruded product using the hot melt extrusion composition , a solid dispersion of decoquinate , and pharmaceutical uses of the composition and the solid dispersion of decoquinate . the hot melt extrusion composition comprises 5 to 30 % of decoquinate , 60 to 90 % of a polymeric carrier and 0 to 10 % of a surfactant . the hot melt extrusion composition can be melted into a liquid at a temperature below the melting point of decoquinate to achieve complete mixing , effectively avoiding the possible thermal decomposition of decoquinate and other components of the composition during the hot - melt process , thus retaining their original structures and pharmacodynamic activity . in the solid dispersion of decoquinate according to the present invention , the active pharmaceutical ingredient and the formulation excipients are melted into amorphous material with homogeneity , possessing improved solubility and drug releasing rate as well as enhanced oral bioavailability and efficacy .