a bioadhesive includes a crosslinked biodegradable hydrogel that includes a plurality of oxidized , acrylated or methacrylated , natural polymer . bioadhesives are natural or synthetic materials that can be used for soft tissue repair to create a seal preventing leakage of biological fluids or to reinforce anatomic integrity as an attractive alternative to sutures and staples . the most widely used bioadhesives are fibrin , cyanoacrylates , and albumin - glutaraldehyde bioadhesives .