it is described a new method for the preparation of pharmaceutical tablets carrying poorly soluble in water principle ; this method allows to obtain tablets with fast and / or slow release of the active principle . the peculiar feature is the fact that the poorly soluble in water active principle is treated with a surfactant , during the granulation phase or whatever during the preparation process ; the obtained product , subjected to a compression , produces pharmaceutical tablets which show high bioavailability of the carried active principle . this procedure can be used to prepare polymeric matrixes , formed by tablets with one or more layers . the procedure of manufacture and the characteristics of the new finished tablet are described .