the present invention relates to amphiphilic drug - oligomer conjugates capable of traversing the blood - brain barrier and to methods of making and using such conjugates . an amphiphilic drug - oligomer conjugate comprises a therapeutic compound conjugated to an oligomer , wherein the oligomer comprises a lipophilic moiety coupled to a hydrophilic moiety . the conjugates of the invention further comprise therapeutic agents such as proteins , peptides , nucleosides , nucleotides , antiviral agents , antineoplastic agents , antibiotics , etc ., and prodrugs , precursors , derivatives and intermediates thereof , chemically coupled to amphiphilic oligomers .