macroporous polymer substrates have greater immobilization capacity for large biomolecules and better access for analytes than substrates used previously for microarrays . microarrays are fabricated with macroporous polymer substrates , and nucleic acids , proteins and peptides are immobilized in the substrate . microarrays with macroporous polymer substrates are useful in immunoassays , drug discovery studies and other biotechnological applications that involve large scale macromolecular interactions . nucleic acid hybridizations , protein binding , and antigen - antibody interactions are analyzed using microarrays with macroporous polymer substrates .