the invention relates to certain low - molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides excreted by mesophilic marine bacteria from a deep hydrothermal environment , wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native epss followed by a step of sulphating the resulting depolymerised derivatives . the present invention further relates to the use of said low - molecular weight sulphated polysaccharide derivatives as a wound - healing agent , particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues . the figure demonstrates how polysaccharide derivative gy 785 drs according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg g / ml .