the present disclosure relates to a composition for treatment and / or prevention of infections , namely bone diseases , in particular osteomyelitis , via a controlled release of antibiotics and subsequently induce regeneration of bone tissue that often undergoes necrosis due to infection . the present disclosure relates in particular to a pharmaceutical composition comprising one or more granules containing calcium phosphate , collagen and one or more polymers of heparin , and an antibiotic in an effective therapeutic amount , wherein the antibiotic is bound to the heparin polymers .