in some embodiments , without limitation , the invention comprises a micromachined probe with one or more buried flow microchannels , where at least one of the microchannels is filled with an organic polymer . in some additional embodiments , the invention comprises a micromachined probe having at least a portion of one external surface coated with an organic polymer . the internally or externally applied organic polymer increases the buckling strength of the micromachined probe and decreases the risk of fracture of the probe , or movement or migration of broken fragments , during insertion , use , or removal from biological tissues .