the disclosure is directed toward instrumentation / processes for generating multiple datapoints from a sample of multiple comingled labeled biopolymers . in one embodiment , it relates the description of optical approaches used to integrate the samples , the optical approaches used to alter the light path along the “ z ” axis perpendicular to the “ x ” and “ y ” axes of a plate containing multiple samples in multiple sample wells and thereby provide greater functionality and the integration of these approaches with purification methods . alternatively , it provides methods of analyzing beads with multiple labeled nucleic acids attached .