a method of using micromechanical devices as sensors for detecting chemical interactions between naturally occurring bio - polymers which are non - identical binding partners is provided . the method is useful whether the reactions occur through electrostatic forces or other forces . induced stress , heat , or change in mass is detected where a binding partner is placed on a cantilever for possible reaction with an analyte molecules . the method is particularly useful in determining dna hybridization but may be useful in detecting interaction in any chemical assay .