the present invention generally related to a nanofabricated membrane including polymerized proteoliposomes . the nanofabricated membrane is a bio - nano fused selective membrane using protein - incorporated uv - crosslinkable liposomes with a chemical reactive biocompatible interstitial matrix . in the present invention , internally uv - crosslinked protein - incorporated proteolipsomes are used because the proteoliposomes made by natural lipids have a short life time and a weak resistance to the circumstantial stresses such as a high and low temperature , pressure , ionic strength etc . furthermore , the proteo - vesicles made by amphiphilic block copolymers provide less consistency in accomplishing proper functionality batch to batch because of the inevitable polydiversity of the polymer .