the invention relates to tissue adhesives or sealants , more specifically to fibrinogen based sealants reinforced with particulate material and chemically cross - linked . more particularly , the present invention is directed to tissue sealant , adhesive , hemostat , or scaffolding material containing thrombin , fibrinogen , a biocompatible particulate material having amine functionality , and a biocompatible polymer containing aldehyde groups . the present invention is also directed to methods for the use of such materials .