a sanitary slider valve shown specifically as a rotary carousel diaphragm valve which has a thermoplastic elastomeric diaphragm integrally molded to form the multiple sealing ports of the rotor / stator interface is described . ports or grooves molded into the face of the elastomeric diaphragm are positioned to sealably engage grooves or ports in the stator face , and to form sanitary elastomeric tubular ducts leading through the body of the rotor or of the stator , terminating as elastomeric flanges . these flanges permit direct connection to sanitary flared piping flanges within the carousel which lead to and from multiple columns or other solid phase bed segments , or to sanitary flared piping flanges connecting the stator to piping interconnecting the multiple carousel columns to each other and to external supply and collection lines . sanitary operation is made operable by energized flexible diaphragm wiping lip seals which maintain fluid - tight sealing engagement with the opposing face even when the rotor is lifted off the stator far enough to permit cross flushing of the port sealing faces with sanitizing fluid . the valve permits sanitary operation of advanced chromatographic separations of biopharmaceuticals , including simulated moving bed chromatography .