the present invention relates to a temperature - sensitive thermogelling emulsion system for bioactive substances , consisting of a biodegradable temperature - sensitive aqueous phase polymer solution , and a pharmaceutically acceptable oil phase carrier , which embeds the bioactive substance . the oil phase carrier and the temperature - sensitive polymer solution are mixed mutually to produce the emulsion , and the emulsion is a liquid while the temperature is below the lower critical solution temperature and reversibly transforms into a gel while the temperature is above said lower critical solution temperature . the emulsions are able to offer the controlled release without burst effect and afterward in a near zero order manner , as well as be non - invasively monitored post - implantation . the design of entrapment of the bioactive substances in the oily phase is also beneficial to preserve the bioactivity of the environment - sensitive substances .