among the conventional methods for producing a solid dispersion , the solvent method is renowned for providing a solid dispersion that has improved solubility and bioavailability for poorly soluble drugs . however , the solvent method often uses volatile organic solvents such as dichloromethane , acetone and alcohol , causing problems such as the organic solvents remaining in the product , environmental pollution , workplace safety as well as the cost of the equipment necessary to avoid these concerns . accordingly , a novel process is provided for preparing a solid dispersion without using the organic solvents often used in a conventional solvent method . that is , it is found that a solid preparation excellent in solubility can be obtained by carrying out a non - solvent coating method in which a core particle or particles are coated with an enteric coating agent and a plasticizer composition comprising a poorly soluble drug dissolved in a plasticizer .