the present disclosure relates to a multi - chamber bioreactor , preferably in a polymeric material with a 3d structure , adapted for cell - mono and co - culture , with at least two entries and outputs of culture medium adaptable to be used as a static culture system and to incorporate a dynamic platform creating a bioreactor . the disclosure also relates to a technique based on a bioreactor device that allows the creation of two or more different tissues integrated with the natural phenotype , using an integrated and continuous 3d support structure .