a method for sequence - based diagnosis of a human neoplastic tissue , blood or other body fluid sample , comprises analysing from genomic dna or cdna derived from said neoplasia the dna sequence of a gene encoding a cancer - related protein for the presence of mutations therein , determining from the presence , nature and location of any such mutation or mutations the influence thereof on the biological function of the corresponding protein and thereby on the properties of the neoplasia , and on the basis thereof prognosticating the development of the neoplasia .