provided , among other things , is a method of treating or ameliorating an indication of mucosal or adjacent tissue comprising periodically applying to mucosa at or adjacent to disease affected tissue a rinse comprising : an effective amount of appropriate composition of herbal bioactive comprising active of one or more of sambucus nigra , centella asiatica or echinacea purpurea ; an antimicrobially effective amount of a quaternary ammonium surfactant ; and optionally a polymer or mixture of polymers effective to coat said tissue and entrap said extract .