a reusable sponge or foam made of a polymer such as polyurethane is prepared containing a plurality of different enzymes or a cross - linked complex of the plurality of enzymes for detoxification of a diverse array of hazardous chemicals such as organophosphorus and / or organosulfur compounds . the plurality of enzymes include enzymes selected from acetylcholinesterase , butyrylcholinesterase , triesterase , pseudocholinesterase , choline oxidase , peroxidase , organophosphate hydrolase , phosphotriesterase , paraoxonase and laccase . a preferred mixture of enzymes contains organophosphate hydrolase and acetylcholinesterase or butyrylcholinesterase . the sponge or foam may additionally contain carbon , an enzyme reactivation compound and / or an indicator for measuring capacity for detoxification . the indicator can be fluorescent , chemiluminescent or visible chromogen or an electrode , and be encapsulated in a liposome or crushable packet . the sponge or foam may be color - coded to indicate specific chemical detoxified , or to indicate enzymatic concentration , activity and / or remaining shelf - life . a kit is formed containing the sponge or foam and the compound for enzyme reactivation .