clotfoam is an hemostatic agent designed for use in cases of non - compressible hemorrhage . it can be applied outside the operating room through a mixing needle and / or a spray injection method following abdominal , chest , extremities or other intracavitary severe trauma to promote hemostasis , or it can be used in the operating room for laparoscopic procedures or other surgical procedures in which compression is not possible or recommended . its crosslinking technology generates an adhesive three - dimensional polymeric network or scaffold that carries a fibrin sealant required for hemostasis . when mixed , clotfoam produces a foam that spreads throughout a body cavity reaching the lacerated tissue to seal tissue and promote the coagulation cascade . the viscoelastic attachment properties of the foam as well as the rapid formation of a fibrin clot that ensure that the sealant remains at the site of application without being washed away by blood or displaced by movement of the target tissue . the fibrin components are produced by a novel method which does not present thrombin to immune system and can be maintained in solution for six weeks without significant proteolytic degradation .