a biodegradable antithrombotic conjugate having heparin and other anti - thrombotic moieties are introduced as side chains to the polymer backbone modified by click chemistry . various bioabsorbable monomers and dimers such as valerolactone may be used in the monomer derivation , homo - and co - polymerization , and the conjugation with a biologically active molecule by click chemistry . a coating comprising a biocompatible and bioabsorbable polymer anti - thrombotic conjugate is applied to at least a portion of an implantable device to prevent or reduce the formation of thrombosis on the surface of the implantable device . a first or sub - layer of the coating is prepared by mixing a polymeric material and a biologically active agent with a solvent , thereby forming a homogeneous solution . a second or outer layer comprising the present anti - thrombotic conjugate may be applied over the inner drug - containing layers using , for example , a dip coating or spray coating process .