this invention relates to sustained release formulations comprising silk fibroin biopolymer and adenosine , that provide for sustained , focal release of adenosine at therapeutic levels for the treatment of epilepsy and / or the prevention of epileptogenesis . an embodiment provides for a silk - based , adeno sine - releasing implant that alleviates seizures or prevents epileptogenesis . another embodiment provides for a method of treating epilepsy or preventing epileptogenesis comprising focally administering adenosine in a sustained - release , silk - based adenosine delivery system .