a pharmaceutical composition for parenteral administration comprising a therapeutically effective amount of a protein or polypeptide and colloidal particles . the particles comprise approximately 1 - 20 mole percent of an amphipathic lipid derivatized with a biocompatible hydrophilic polymer . the protein or polypeptide is selected from the group consisting of proteins or polypeptides capable of externally binding said colloidal particles ; proteins or polypeptides capable of binding polymers of the polyalkylether , polylactic and polyglycolic acid families ; and proteins or polypeptides that include a consensus sequence of s / t - x / i / v - i / v / q / s - s / t - x - x - x - e , where x may be any amino acid , and s , t , l , i , v , e and q have their standard meanings . the protein or polypeptide is not factor viii and is not encapsulated in the colloidal particles .