the invention described herein teaches methods of removing microvesicular particles , which include but are not limited to exosomes , from the systemic circulation of a subject in need thereof with the goal of reversing antigen - specific and antigen - nonspecific immune suppression . said microvesicular particles could be generated by host cells that have been reprogrammed by neoplastic tissue , or the neoplastic tissue itself . compositions of matter , medical devices , and novel utilities of existing medical devices are disclosed .