among the conventional processes for producing solid dispersion , the solid dispersion obtained by a solvent method is excellent in terms of solubility and bioavailability of a poorly soluble drug . however , due to frequent uses of organic solvents in the solvent method , problems have arisen such as organic solvent residue in products , environmental pollution and operational safety as well as corporate problems such as capital investment and the like required to avoid such events . the present invention provides a process for preparing pharmaceutical solid preparations without use of organic solvents frequently used in conventional solvent methods . specifically , the present invention provides a process for producing a pharmaceutical solid preparation , which is formulated by spraying a solution wherein a poorly soluble drug is dissolved in a plasticizer , and an aqueous solution and / or water dispersion of a water - soluble polymer from nozzle outlets simultaneously and separately in the process for producing the pharmaceutical solid preparation .