methods and constructs including a fixation device and a suture for fixation of soft tissue to bone , or of soft tissue to soft tissue , which amplifies the body &# 39 ; s healing response created by the introduction of the suture material and the material properties of the fixation device . fixation of soft tissue to bone is conducted using a suture and a fixation device . the suture and fixation device are manufactured from materials that have properties to amplify the body &# 39 ; s healing response . materials such as synthetic bioresorbable polymers are utilized in the fabrication of orthopedic fixation devices . once these materials are introduced into the body and are exposed to in vivo conditions , the devices manufactured with these materials undergo hydrolysis and degrade while maintaining specific mechanical properties over time .