liquid bioadhesive microemulsions or liposomic dispersions containing proteinic substances , especially calcitonin , that allow the systemic , local or topical administration of drugs by transmucosal route are described . this type of administration shows some considerable advantages of activity , tolerability , dosage individualization and drug stability . the compositions contain proteinic substances , and a polyoxyethylene - polyoxypropylene thermosetting copolymer . at body temperature the viscosity of the compositions is increased and provides increase residence time at the administration site .