the present invention is directed to several multisubstrate adduct inhibitors of glycinamide ribonucleotide transformylase , a folate - requiring enzyme of de novo purine biosynthesis . the compounds of the present invention will be useful to provide anti - gout and / or anti - neoplastic therapeutic agents or will serve as potentiators for other such agents . the most prefeffed , potent tight - binding multisubstrate adduct inhibitor of glycinamide ribonucleotide transformylase , is n 10 -- 5 , 8 - dideazafolate , which has the chemical formula : ## str1 ##