this biomaterial comprises at least a compound consisting of an association of collagen , chitosan acetylated to a degree of acetylation between about 10 and about 40 % and of glycosaminoglycans . it has its application in orthopedics and plastic surgery and for making extracellular matrices for regeneration of nerve cells and bones as well as biocompatible envelopes . a particular application is the making of artificial skin consisting of a dermal layer of the velvet type obtained from biomaterials such as those described above . the process of obtaining this dermal layer consists in adding a collagen solution of the chitosan , then in adding to the collagen - chitosan a mixture of chondroitins 4 - and 6 - sulfate .