a novel polymeric support is provided for carrying out the synthesis of oligonucleotide analogs via solid - phase synthesis techniques . the suitably - shaped polymeric disc , wafer , etc ., of the invention may be made of polystyrene , silica gel , glass beads , polyamide / kieselguhr , cellulose , etc . the suitably - shaped disc or wafer of the invention should , preferably , have a thickness of 200 - 400 μm and may be of any suitable length or width . a process for the synthesis of oligonucleotide analogs utilizing the polymeric support of the present invention is also disclosed .