the present invention provides a packing for chromatography . specifically , it provides a packing for chromatography in which a hydrophilic polymeric material is bound to the surface of a porous carrier , and a carbon chain is chemically bound inside the pore . by the use of the packing according to the present invention for analysis of low molecular weight compounds in a biological sample , a pretreatment such as removal of proteins etc . becomes unnecessary , and the biological sample can be directly analyzed .