a bio - mimetic or bio - implantable material based on a sequential process of coupling biomolecule layers to a polymer layer is provided . in general , the material could be based on two or more biomolecule layers starting with one of the layers covalently linked to the polymer layer via cross - linkers and the other layers sequentially and covalently linked using cross - linkers to the previously added layer . the polymer layer could be a hydrogel or an interpenetrating polymer network hydrogel . the first layer of biomolecules could be a collagen type , fibronectin , laminin , extracellular matrix protein , or any combinations thereof . the second layer of biomolecules typically is a growth factor , protein or stimulant . the cross - linkers are either water soluble or insoluble bifunctional cross - linkers or azide - active - ester crosslinkers . the material and process as taught in this invention are useful in the field of tissue engineering and wound healing .