an integrated proteomics sample preparation device and method for in - gel digestion of proteins and for desalting and concentrating samples prior to further analysis such as by maldi tof and / or electro - spray ionization mass spectrometry . the device in accordance with an embodiment of the present invention includes a plurality of wells in fluid communication with a an outlet or drainage opening containing a three dimensional structure comprising a plurality of sorptive particles entrapped in a porous polymer matrix so as to form a device capable of carrying out solid phase extraction . in a preferred embodiment , the wells are configured so as to prevent a sample carrier present in the wells from clogging the outlet when subjected to a driving force such as vacuum . the device also reduces or eliminates overflowing of a well in the event a drain becomes clogged during automated operation .