the present invention relates to a composite biomaterial and a process for producing a composite biomaterial with controlled release of active ingredients , comprising a three - dimensional polymer - based support structure , and a polymer - based matrix structure . the active ingredients are in this case incorporated into the composite biomaterial via the matrix structure , and the composite biomaterial is obtainable by introducing the matrix structure into the support structure . the active ingredients may in this case be incorporated for example adhesively , via specific binder molecules or via enzyme - labile linker molecules via the matrix structure into the composite biomaterial .