the invention is to articles made from extracellular matrix sheets that encase biodegradable polymeric material . methods of healing wounds or regenerating tissue at sites of defect by placing said articles in mammals are claimed . the biodegradable polymer can change quality upon contact with a physiological parameter such as temperature or ph that causes , for example , a liquid polymer to gel or harden . the degradation of the polymer can be controlled to suit a tissue regeneration or wound healing time course . additional components such as proteins , cells and drugs can be added to the biopolymer composition .