a method for preparing synthetic polymerized resins for ion exchange , namely , carboxylic cationites , which are suitable as sorbents for preparative separation and purification of biologically active compounds by low pressure liquid chromatography . the directional polymerization conditions enable such cationites to be prepared with polymeric structures which can be used for the separation of macromolecules , such as proteins , with high molecular mass from various microbiological raw materials and physiological liquids . depending upon the embodiment of the method of manufacture according to the present invention , the resultant carboxylic cationites are obtained in one of three forms : a swollen block , if no pre - polymerization or dispersion stages are performed ; and , if such stages are performed , depending upon the dispersion conditions , the resultant structures can be either irregular particles or spherical granules .