in accordance with certain embodiments of the present disclosure , a method for fabricating multi - layer fibrous scaffolds with a well - defined pore geometry is provided . the method includes electrospinning generally parallel rows of biodegradable synthetic polymer fibers onto a collector plate , wherein the fibers of each generally parallel row on the collector plate are generally aligned as they are electrospun onto the collector plate . the collector plate is rotated and additional generally parallel rows of biodegradable synthetic polymer fibers are electrospun onto the collector plate , wherein the additional fibers on the collector plate are generally aligned as they are electrospun onto the collector plate and a multi - layer scaffold is formed . the process can be continued to form a multi - layer fibrous scaffold with macropores of well - defined geometry .