a process for manufacturing a fiber or other device with a biocompatible coating for using the fiber in solid phase microextraction of a small molecule of interest from a matrix . the process includes the step of coating the fiber / device with a coating of a biocompatible polymer and a solvent having solid phase microextraction particles with pores dimensioned to absorb the small molecule of interest from the matrix suspended therein . the process also includes the steps of drying the coated fiber / device to remove the solvent and curing the dried coated fiber at an elevated temperature .