an enzymatically active reusable sponge or foam , capable of regeneration with oximes , made of a polymer such as polyurethane is prepared for detoxification of hazardous compounds such as organophosphorus and organosulfur compounds . the foam or sponge contains a plurality of enzymes including enzymes selected from acetylcholinesterase , butyrylcholinesterase , triesterase , pseudocholinesterase , organophosphate hydrase , phosphotriesterase , paraoxonase and organophosphorus and organosulfur hydrolyzing enzymes . the sponge or foam may additionally contain activated carbon and an enzyme reactivation compound . a kit can be formed containing the sponge or foam and the compound for enzyme reactivation . the enzymatically active foam or sponge may be prepared using a two chamber device where enzymes and prepolymer are passed from separate chambers into a static mixing stator and are subjected to low shear mixing and extrusion to form by the sponge or foam .