this invention relates to macromolecule modifiers containing biologically active drugs / biomolecules , or precursors thereof , and fluoroligomers ; compositions comprising the macromolecules containing the drugs and fluoroligomers in admixture with polymers , particularly biomedical polymers ; articles made from the admixtures , particularly medical devices . specifically , the modifier has the general formula comprising an oligomeric polymeric segment having a theoretical molecular weight of less than 15 , 000 , and being compatible with said base polymer ; wherein is a first oligomeric segment ; is a second coupling segment linking one to another within said central portion ; n is 0 to 20 ; is a polyfluoro oligomeric group ; and is a first coupling segment linking said central portion to said through said first coupling segment ; and coupled to a bioactive moiety or precursor thereof ; and m is 1 to 20 .