the main goals of the invention are to develop the long - term release of granisetron injection implant composition with biodegradable polymer and to develop relative processing . granisetron is mixed with different biodegradable polymers , and then hot melt extrusion technique with different diameter , temperature , rate of extrusion and holding time is applied to make implant . in vitro dissolution of the granisetron injection implant composition shows the component continued release of the drug for over 7 days .