it comprises : preparing an aqueous phase containing surface active suspensor agents and , optionally , a chemically or biologically active chemical substance ; preparing an organic phase containing a biocompatible polymer or monomer and , optionally , a lipid or chemically or biologically active chemical substance ; mixing both phases in a continuous manner in a constant average phase - volume ratio , continuously removing a recently formed colloidal suspension ; continuously eliminating the solvent from the colloidal suspension ; and completely eliminating the organic solvent and part or all of the water in order to obtain the desired concentration of nanospheres or dry product . application in biomedicine , pharmacy , medicine , cosmetics , chemical industry , agriculture , veterinary science , etc .