How to Play With a Hamster
Wash your hands before you play with your hamster, since hamsters are very sensitive to smells. Place your hand inside its cage and let it sniff your hand. If you like, you can give it treats to help it relax. Once the hamster is comfortable with your hand being in its cage, place one hand under its chest and the other hand under its bottom and gently lift it towards you. Talk to it in a gentle voice and be careful not to squeeze it too hard. Carefully lower the hamster back into its cage when you are finished playing with it.
Let your hamster adjust to his new environment. Handling your hamster is a great way to bond with your hamster, but he will need some time to adjust to his new home. Give him about 12 to 24 hours to explore his cage and become comfortable with his surroundings. During this time, you can gently talk to him or interact with him, but do not put your hand in his cage. Your hamster will need a large cage so that he has plenty of space to run and play. The minimum size cage is 59 cm x 36 cm X 25 cm (approximately 23 in x 14 in x 10 in). Ideally, his cage should also have some tubing and ladders. Wash your hands. Hamsters do not see very well and typically use their nose to pick up on cues from their environment. For example, if you have just eaten something and then go to handle your hamster, he will smell the food on your hands and may try to bite you. If you have more than one hamster, one hamster could pick up on the scent of the one that you just handled, which could be perceived as being attacked by the other hamster. Use unscented soap to wash your hands If you are handling multiple hamsters, wash your hands before and after handling each hamster. Place your hand inside the cage. Before your hamster will be comfortable with you handling him, he will first need to get used to your hand. Place your hand in his cage and leave it there for him to sniff and explore. If he tries to bite or nibble your hand, pull your hand away slowly and gently blow on his face to discourage that behavior. Hamsters are prey animals, so putting your hand in his cage could resemble a bird reaching down to swoop him up. The more comfortable he becomes with your hand, the less afraid he will be of you picking him up. It may take anywhere from a few hours to a few days before he is used to your hand. Feeding him treats can also help him get used to your hand being in his cage. Pick him up. When your hamster no longer sees your hand as a threat, you can start picking him up. Slowly reach into the cage and let him see and sniff your hand first. Then, place one hand under his chest and one hand on his bottom and gently lift him up towards you. Talk to him in a gentle voice and make sure not to squeeze him too tightly. Sitting on the ground or standing over a tabletop are the best places to hold him. Your hamster may want to jump, which could cause injury, so you want to make sure that you are as close to a solid surface as possible. After you pick him up, you can also try lying back on the floor and allowing him to walk around on your chest. If you are having trouble picking him up in your hands, you could also lift him outside of his cage by gently nudging him into a cup or small bowl. Keep in mind that hamsters generally do not enjoy being handled for long periods of time. Begin by holding him for a few seconds and gradually increase the amount of time that you hold him. If he gets squirmy, place him back in his cage as gently and slowly as you picked him up. Because they are prey animals, hamsters are wary of sudden changes in their environment. Slowly reaching in and picking up your hamster will help reduce his fear that he is being scooped up by a predator. Do not punish your hamster if he bites. Hamsters generally do not respond to punishment because they cannot make a clear association between the behavior and the consequences. Rather than yelling or hitting your hamster, you can gently blow on his face and say “no” in a firm voice. The air on his face will probably cause him to rear back and squint. That should be enough to discourage him from biting you again. Hamster-proof the area. Your hamster will need daily playtime outside of his cage. To make this an enjoyable experience for him, you will need make sure that his play area is safe. For example, you will need to remove or hide any electrical cords that he could nibble on. You should also block any possible areas where your hamster could squeeze or hide in, such as under furniture or between couch cushions. If you have other pets, they should not be allowed in your hamster's play area. A clean bathroom is a good area for your hamster to play in. Make sure that the toilet lid is closed so that he does not accidentally fall in the toilet. Place him in an exercise ball. An exercise ball is a great way for your hamster to exercise. Exercise balls are available at your local pet store in different varieties. Because hamsters do not see very well, make sure that the exercise ball you choose is made of clear plastic. After you gently place your hamster in the ball, put a piece of tape over the ball's door so that it does not open while your hamster is in the ball. Place the ball in a carpeted area, which will give the ball extra traction. Supervise your hamster closely when he is in the ball so that he does not run into any furniture or get too close to a set of stairs. Keep him in the ball for no longer than 20 minutes and provide him with food and water when you place him back in his cage. Place him in a large playpen. A playpen is another way that your hamster can play outside of his cage. Ideally, the playpen should be larger than his regular cage. To make the playpen fun for him, place some of his toys inside of it. Supervise him closely so that he does not climb out of his playpen and escape. Playpens are available at your local pet store. Allow him to run around in an open area. You can also let your hamster explore the hamster-proofed area without being in an exercise ball or playpen. If you are in the bathroom, you could place him in the tub and let him run around. Place some of his toys in the open area and create some obstacle courses to keep him interested. The obstacle course can be made of common household items, such as empty cardboard boxes and toilet paper rolls. Look for your hamster if he runs away. Despite your best efforts to hamster-proof the area and keep a close eye on your hamster, he may still find a way to escape and hide. If you cannot find him when playtime is over, check the places where he would be most likely to hide: behind or underneath furniture, between seat cushions, inside of drawers or boxes, etc. If you have searched all of these places with no luck, consider placing food near or inside of his cage to encourage him to come back to his cage. Place an exercise wheel inside of his cage. An exercise wheel is considered the mainstay of a hamster's exercise. An exercise wheel with wires or mesh could injure your hamster's paws, so select an exercise wheel that has a solid bottom. Also, look for one that can attach to one of the interior sides of your hamster's cage. The exercise wheel should be large enough (minimum 12 inches in diameter) to prevent your hamster's back from bending when he is running on the wheel. Listen to the wheel when your hamster is running on it. If it is noisy, you may want to consider moving your hamster's cage to an area outside of your bedroom. Hamsters are nocturnal animals, so your hamster would likely be running on his cage during the night. Place toys inside of his cage. Your hamster will want to do more than just run on his exercise wheel. He will also enjoy running through tunnels and having toys that he can nibble on. The chew toys will help keep your hamster's teeth filed down. Rather than buying a lot of toys at your local pet store, you could make homemade toys. Supervise your hamster. Although your hamster will likely not escape from his cage, you still want to make sure that his play is safe inside of his cage. For example, if his cage is made of wire, he may try to climb up the sides of the cage. Not only could the wire injure his paws, but he could also get seriously injured if he falls down when trying to climb. If you see him trying to climb, you could slowly reach into his cage and gently place him back on the cage floor. 
Let your hamster adjust to his new environment. Wash your hands. Place your hand inside the cage. Pick him up. Do not punish your hamster if he bites. Hamster-proof the area. Place him in an exercise ball. Place him in a large playpen. Allow him to run around in an open area. Look for your hamster if he runs away. Place an exercise wheel inside of his cage. Place toys inside of his cage. Supervise your hamster. 