page_title: Alternative oxidase
hierarchical_section_title: Alternative oxidase
caption_attribution_description: English: Alternative oxidase pathway in mitochondrion. Modified version of a portion of an image taken from figure 1 of Evolution of energy metabolism and its compartmentation in Kinetoplastida VÃ©ronique Hannaert, FrÃ©dÃ©ric Bringaud, Fred R Opperdoes and Paul AM Michels
context_page_description: The alternative oxidase is an enzyme that forms part of the electron transport chain in mitochondria of different organisms. Proteins homologous to the mitochondrial oxidase and the related plastid terminal oxidase have also been identified in bacterial genomes.
  The oxidase provides an alternative route for electrons passing through the electron transport chain to reduce oxygen. However, as several proton-pumping steps are bypassed in this alternative pathway, activation of the oxidase reduces ATP generation. This enzyme was first identified as a distinct oxidase pathway from cytochrome c oxidase as the alternative oxidase is resistant to inhibition by the poison cyanide.
context_section_description: The alternative oxidase (AOX) is an enzyme that forms part of the electron transport chain in mitochondria of different organisms. Proteins homologous to the mitochondrial oxidase and the related plastid terminal oxidase have also been identified in bacterial genomes.
  The oxidase provides an alternative route for electrons passing through the electron transport chain to reduce oxygen. However, as several proton-pumping steps are bypassed in this alternative pathway, activation of the oxidase reduces ATP generation. This enzyme was first identified as a distinct oxidase pathway from cytochrome c oxidase as the alternative oxidase is resistant to inhibition by the poison cyanide.
caption: The alternative oxidase shown as part of the complete electron transport chain. UQ is ubiquinol/ubiquinone, C is cytochrome c and AOX is the alternative oxidase.
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