page_title: FAM208b
section_title: Homologous Domains
hierarchical_section_title: FAM208b / Homology and Evolution / Homologous Domains
caption_attribution_description: English: Allignment of FAM208b and its paralog FAM208a, highlighting identified domains of unknown function: DUF3699 in blue, DUF3715 of FAM208b in yellow, DUF3715 of FAM208a in red, and their overlap in orange.
context_page_description: Protein FAM208B is a protein that in humans is encoded by the FAM208B gene. The gene is also known as "chromosome 10 open reading frame 18". FAM208B is expressed throughout the body however its function has not been established. FAM208b has been observed to be differentially regulated in various cancers and throughout development. While the exact role of the protein is yet to be established, the significant presence of the protein within humans and throughout the phylogenetic tree depicts a central importance of the gene in normal function.
context_section_description: FAM208b has highly conserved N- and C- termini and a less conserved central region. Three domains of unknown function (DUFs) are found within the protein, including one DUF 3699 and two DUF 3715. All three DUFs are conserved between species. DUF 3715 is found in the paralog of FAM208b.
caption: Alignment of FAM208b and its paralog FAM208a, highlighting identified domains of unknown function: DUF3699 in blue, DUF3715 of FAM208b in yellow, DUF3715 of FAM208a in red, and their overlap in orange.
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