page_title: Epithelioid cell
section_title: Peculiarities of the cytoskeleton
hierarchical_section_title: Epithelioid cell / Peculiarities of the cytoskeleton
caption_attribution_description: English: Epithelioid cells (polarized form, nucleus color - green) and macrophages (nucleus color – red) in peritoneal cell culture of mice, stimulated by inactivated Mycobacteria tuberculosis, on the 10th day of cultivation. The pseudo color image was obtained by color coding of different optical densities in a photo of cells, stained by Azure-Eosine. The shape of cells determined by their cytoskeleton, and the color characterizes the different their cytomorphology.
context_page_description: According to a common point of view epithelioid cells
  are derivatives of activated macrophages resembling epithelial cells.
context_section_description: It is shown that the epithelioid cell cytoskeleton formed by filaments differs significantly from the macrophage cytoskeleton. A large increase in the number of filaments occurs in these cells, where filaments (90 to 100 A) surround the cytocentrum as a distinctive annular bundle often branching into the cytoplasm. Due to such cytoskeleton contiguous epithelioid cells display elaborate cytoplasmic interdigitation. By using the QF-FS-method (prompt freezing, penetrating etching and freeze-substitution) it has been shown that the organizations three-dimensional metastructure cytoskeleton of the epithelioid cells, formed in the focus of granulomatous inflammation, more compatible to cytoskeleton characteristic of typical epithelial cell than to cytoskeleton of active and movable macrophages. It is exhibited that the dense webs of intermediate filaments, bound with cores, mitochondrions and other organellas, are supervised everywhere in cytoplasm of epithelioid cells. Some fascicles of actinic filaments were posed in filopodiums below than membranes of the cells. Exact interdigital triping of membranes of cells between interfacing epithelioid cells were clearly demonstrated. Interdigital filopodiums were identified. The characteristic indication of epithelioid cells is their aggregation with formation tight interdigital tripings as a fastener "lightning", which, apparently, can have the important for the formation of a dense zone of delimitation of the body from the pathogen during the formation of epithelioid cell granulomas.
caption: Epithelioid cells (polarized form, nucleus color - green) and macrophages (nucleus color – red) in peritoneal cell culture of mice,  stimulated by inactivated Mycobacteria tuberculosis, on the 10th day of cultivation. The pseudo color image was obtained by color coding of different optical densities in a photo of cells, stained by Azure-Eosine. The shape of cells  determined by their cytoskeleton, and the color characterizes the different their cytomorphology.
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