page_title: Aneurysmal bone cyst
section_title: Pathology
hierarchical_section_title: Aneurysmal bone cyst / Pathology
caption_attribution_description: English: Very high magnification micrograph of an aneurysmal bone cyst, abbreviated ABC. H&amp;E stain. ABCs have many giant cells; however, unlike giant cell tumours of bone the cells in the background are spindle cells. Giant cell reparative granuloma may be considered to be a variant of ABC.[1] Related images Intermed. mag. High mag. Very high mag. References ↑ (Jan 2012). "A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst).". Hum Pathol. DOI:10.1016/j.humpath.2011.10.003.
context_page_description: Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several sponge-like blood or serum filled, generally non-endothelialized spaces of various diameters.
  The term is a misnomer, as the lesion is neither an aneurysm nor a cyst.
context_section_description: Histologically, they are classified in two variants. 
  The classic (or standard) form (95%) has blood filled clefts among bony trabeculae. Osteoid tissue is found in stromal matrix.
  The solid form (5%) shows fibroblastic proliferation, osteoid production and degenerated calcifying fibromyxoid elements.
  According to Buraczewski and Dabska, the development of the aneurysmal bone cyst follows three stages.
  They can also be associated with a TRE17/USP6 translocation.
  Aneurysmal bone cysts may be intraosseous, staying inside of the bone marrow.  Or they may be extraosseous, developing on the surface of the bone, and extending into the marrow. A radiograph will reveal a soap bubble appearance.
caption: Micrograph of an aneurysmal bone cyst. H&E stain.
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