page_title: Trans-activation response element (TAR)
hierarchical_section_title: Trans-activation response element (TAR)
caption_attribution_description: English: Image has been uploaded to the Commons as part of the Molecular and Cellular Biology WikiProject in collaboration with the public-domain database Rfam. Here is the link to the discussion.
context_page_description: The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter.
  Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.
  These miRNAs are thought to prevent infected cells from undergoing apoptosis by downregulating the genes ERCC1, IER3, CDK9, and Bim.
context_section_description: The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter.
  Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.
  These miRNAs are thought to prevent infected cells from undergoing apoptosis by downregulating the genes ERCC1, IER3, CDK9, and Bim.
caption: Predicted secondary structure and sequence conservation of mir-TAR
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