page_title: Fibrosis
section_title: Anatomical location
hierarchical_section_title: Fibrosis / Anatomical location
caption_attribution_description: Čeština: Histologický obraz cirhózy etylické etiologie (trichrom) English: High magnification micrograph of a liver with cirrhosis. Trichrome stain. The most common cause of cirrhosis in the Western world is alcohol abuse - the cause of cirrhosis in this case.
context_page_description: Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue.
  Repeated injuries, chronic inflammation and repair are susceptible to fibrosis where an accidental excessive accumulation of extracellular matrix components, such as the collagen is produced by fibroblasts, leading to the formation of a permanent fibrotic scar.
  In response to injury, this is called scarring, and if fibrosis arises from a single cell line, this is called a fibroma. Physiologically, fibrosis acts to deposit connective tissue, which can interfere with or totally inhibit the normal architecture and function of the underlying organ or tissue. Fibrosis can be used to describe the pathological state of excess deposition of fibrous tissue, as well as the process of connective tissue deposition in healing.
context_section_description: Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include:
  Lungs
  Pulmonary fibrosis
  Cystic fibrosis
  Idiopathic pulmonary fibrosis (idiopathic meaning the cause is unknown)
  Radiation-induced lung injury (following treatment for cancer)
  Liver
  Bridging fibrosis An advanced stage of liver fibrosis seen in the progressive form of chronic liver diseases. The term “bridging” means ‘the formation of “bridge” (by the band of mature & thick fibrous tissue) obliterating portal area to central vein’, leads to the formation of pseudolobules. The long term exposure of hepatotoxin (like thioacetamide, carbon tetrachloride, diethylnitrosamine, etc.) results in the bridging fibrosis in experimental animal models.
  Cirrhosis
  Brain
  Glial scar
  Other
  Arterial stiffness
  Arthrofibrosis (knee, shoulder, other joints)
  Crohn's disease (intestine)
  Dupuytren's contracture (hands, fingers)
  Keloid (skin)
  Mediastinal fibrosis (soft tissue of the mediastinum)
  Myelofibrosis (bone marrow)
  Peyronie's disease (penis)
  Nephrogenic systemic fibrosis (skin)
  Progressive massive fibrosis (lungs); a complication of coal workers' pneumoconiosis
  Retroperitoneal fibrosis (soft tissue of the retroperitoneum)
  Scleroderma/systemic sclerosis (skin, lungs)
  Some forms of adhesive capsulitis (shoulder)
caption: Micrograph showing cirrhosis of the liver. The tissue in this example is stained with a trichrome stain, in which fibrosis is colored blue. The red areas are the nodular liver tissue
exif: {"Image Make": "Canon", "Image Model": "Canon EOS DIGITAL REBEL XSi", "Image Orientation": "Horizontal (normal)", "Image XResolution": "72", "Image YResolution": "72", "Image ResolutionUnit": "Pixels/Inch", "Image DateTime": "2009:09:18 20:44:33", "Image YCbCrPositioning": "Co-sited", "Image ExifOffset": "192", "Thumbnail Compression": "JPEG (old-style)", "Thumbnail XResolution": "72", "Thumbnail YResolution": "72", "Thumbnail ResolutionUnit": "Pixels/Inch", "Thumbnail JPEGInterchangeFormat": "9118", "Thumbnail JPEGInterchangeFormatLength": "10513", "EXIF ExposureTime": "1/40", "EXIF FNumber": "0", "EXIF ExposureProgram": "Program Normal", "EXIF ISOSpeedRatings": "100", "EXIF ExifVersion": "0221", "EXIF DateTimeOriginal": "2009:09:11 16:37:05", "EXIF DateTimeDigitized": "2009:09:11 16:37:05", "EXIF ComponentsConfiguration": "YCbCr", "EXIF ShutterSpeedValue": "43/8", "EXIF ApertureValue": "2147483648", "EXIF ExposureBiasValue": "0", "EXIF MeteringMode": "Pattern", "EXIF Flash": "Flash did not fire, compulsory flash mode", "EXIF FocalLength": "0", "EXIF SubSecTime": "74", "EXIF SubSecTimeOriginal": "74", "EXIF SubSecTimeDigitized": "74", "EXIF FlashPixVersion": "0100", "EXIF ColorSpace": "sRGB", "EXIF ExifImageWidth": "4272", "EXIF ExifImageLength": "2848", "Interoperability InteroperabilityIndex": "R98", "Interoperability InteroperabilityVersion": "[48, 49, 48, 48]", "EXIF InteroperabilityOffset": "8994", "EXIF FocalPlaneXResolution": "2136000/439", "EXIF FocalPlaneYResolution": "356000/73", "EXIF FocalPlaneResolutionUnit": "2", "EXIF CustomRendered": "Normal", "EXIF ExposureMode": "Auto Exposure", "EXIF WhiteBalance": "Manual", "EXIF SceneCaptureType": "Standard"}