page_title: Sorivudine
section_title: Interactions
hierarchical_section_title: Sorivudine / Interactions
context_page_description: Sorivudine, is a nucleoside analogue antiviral drug, marketed under trade names such as Usevir and Brovavir.
context_section_description: Sorivudine interacts strongly and in some cases lethally with fluorouracil (5-FU), its prodrugs and related substances. This is based on the metabolite bromovinyluracil (BVU), which irreversibly inhibits the enzyme dihydropyrimidine dehydrogenase (DPD) which is necessary for inactivating 5-FU. The closely related drug brivudine has the same interaction.
caption: Bromovinyluracil (BVU)