page_title: Fibro-purF RNA motif
hierarchical_section_title: Fibro-purF RNA motif
context_page_description: The Fibro-purF RNA motif is a conserved RNA structure that was discovered by bioinformatics.
  Fibro-purF motif RNAs are found in Fibrobacteres, a group of bacteria that are common in cow rumen. Additionally, the RNAs are found in metagenomic sequences of DNA isolated from cow rumen.
  Fibro-purF motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes.
  In fact, instances of the Fibro-purF RNA motif are often located nearby to the predicted Shine-Dalgarno sequence of the downstream gene. This arrangement is consistent with a model of cis-regulation where the RNA allosterically controls access to the Shine-Dalgarno sequence, thus regulating the gene translationally.
  All known Fibro-purF RNAs are found upstream of purF genes, which encode amidophosphoribosyltransferase, which participates in the biosynthesis of biological purine molecules. The Fibro-purF motif is found only in closely related organisms. As a result, the RNAs do not exhibit a high degree of mutations when compared, and it was difficult to study the RNA's secondary structure by covariation methods.
context_section_description: The Fibro-purF RNA motif is a conserved RNA structure that was discovered by bioinformatics.
  Fibro-purF motif RNAs are found in Fibrobacteres, a group of bacteria that are common in cow rumen.  Additionally, the RNAs are found in metagenomic sequences of DNA isolated from cow rumen.
  Fibro-purF motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes.
  In fact, instances of the Fibro-purF RNA motif are often located nearby to the predicted Shine-Dalgarno sequence of the downstream gene.  This arrangement is consistent with a model of cis-regulation where the RNA allosterically controls access to the Shine-Dalgarno sequence, thus regulating the gene translationally.
  All known Fibro-purF RNAs are found upstream of purF genes, which encode amidophosphoribosyltransferase, which participates in the biosynthesis of biological purine molecules.  The Fibro-purF motif is found only in closely related organisms.  As a result, the RNAs do not exhibit a high degree of mutations when compared, and it was difficult to study the RNA's secondary structure by covariation methods.  As a result, the predicted secondary structure is uncertain in some places.
  The Fibro-purF RNA motif was considered a potential candidate riboswitch, but no ligand has been established, as of 2018.
caption: Consensus secondary structure and sequence conservation of Fibro-purF RNA