Paradise Kiss
A manga by Ai Yazawa featuring a serious school girl named Yukari (a.k.a. Caroline) who is asked to model the designs of a group of student fashion designers.  The ParaKiss group is composed of:  Isabella, the transvestite; Arashi, the punk with safety pin piercings; Miwako, a childish pink haired girl; and George, the mysterious bisexual leader.
Paradise Kiss is a very popular fashion manga.