DBZ
The acronym for Dragonball Z, it is the only anime whose viewing audience does not primarily consist of nerds and losers.  A large portion of its viewers are actually "cool" (by meaning of social standards).  As a matter of fact, quite a few fans of the series are unfamiliar with the term "anime".
A few of my friends who weight train at the gym gained their inspiration from DBZ.  The show has actually benefited their wellbeing thus far.  Which other animes can be accredited for doing the same?