¿Qué lo de?
In Spanish it means "What of it?", "What it of?" or "Whatever!"

When using the "What of it?" meaning, it is derogatory.
**example "Your eating my candy without permission!" "Yea, what of it? (¿Qué lo de?)

Saying it meaning What it of, typically refers to food, and Whatever can be both derogatory and friendly.
"Your soda is leaking all over the couch!"
"¿Qué lo de?"

"This is my famous home-made casserole!"
"¿Qué lo de?"

"Your being such a stupid bitch!"
"¿Qué lo de?"