sweat out toxins
To run/jog or engage in cardiovascular activity, most often after a night of drinking, in order to rid the body of the toxins associated with said heavy drinking. 
- "Hey, man, wanna go get some brunch?"

- "Naw, bro, I gotta go sweat out toxins, or "s.o.t".  I won't be done jogging until 2:00."