Depression
The state of being in absolute sadness. Usually occurring when constantly being friend-zoned, unable to be respected, or being left out. There are many cures for this, but sometimes if it is not treated, it could result in Chronic Depression, which could lead to worse effects, such as isolation, or suicide.
"My girlfriend broke up with me, now I am currently in depression"
"He's always getting bullied, i'm so concerned if he's depressed right now, maybe I should talk to him."
"My family is in deep depression because we have alot of problems occurring right now