This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Children with germline retinoblastoma are more likely to develop other primary malignancies in their later lifetime course. Which of the following malignancy can occur in such patients? 
Select and explain. 
A. Osteosarcoma of lower limbs, B. Thyroid carcinoma, C. Seminoma, D. Renal cell carcinoma
A: Osteosarcoma of lower limbs
Answer: A: Osteosarcoma of lower limbs 
Explanation: Answer- A. Osteosarcoma of lower limbsChildren with germline retinoblastoma are more likely to develop other primary malignancies in their later lifetime course.Osteosarcoma of lower limbs can occur in such patients.Retinoblastoma Syndrome (Primary site malignancy)- Familial Retinoblastoma