This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2018, Subject name: Pathology
Anti-centromere antibodies are seen in which of the following conditions? 
Select and explain. 
A. Drug-induced lupus, B. SLE, C. Sjogren syndrome, D. Scleroderma
D: Scleroderma
Answer: D: Scleroderma 
Explanation: It is seen in Systemic Sclerosis (Scleroderma). Limited form of scleroderma known as CREST syndrome is characterised by presence of anti-centromere antibodies positive and generalized form shows anti-topoisomerase antibodies Anti-histone antibodies are positive in drug-induced lupus. Anti-SS-A (RO) antibodies and anti-SS-B(LA) antibodies are positive in Sjogren's Syndrome. Most specific in SLE: anti ds-DNA and Anti-Smith antibodies