This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Most commonly implicated drug for acute liver failure is - 
Select and explain. 
A. Paracetamol, B. Valproate, C. Warfarin, D. Tetracyclines
A: Paracetamol
Answer: A: Paracetamol 
Explanation: Ans. A. Paracetamol Acute liver failure after administration of paracetamol at the maximum recommended daily dose in adults.Paracetamol is the most commonly used analgesic and antipyretic in the world; it can be bought without prescription in most countries despite being the commonest cause of acute liver failure in western Europe.Prescribing information suggests that it is safe to use in adults in divided doses that total 4 g daily.Malnutrition, starvation, chronic alcohol misuse, and concomitant use of drugs that induce cytochrome P450 enzymes increase the risk of hepatotoxicity induced by paracetamol.