This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2018, Subject name: Pharmacology
Major determinant of loading dose of a drug is 
Select and explain. 
A. Half life, B. Clearance, C. Volume of distribution, D. Bioavailability
C: Volume of distribution
Answer: C: Volume of distribution 
Explanation: LOADING DOSE = Vd * target plasma concentration MAINTENANCE DOSE = Clearance * target plasma concentration