This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Which of the following is not glucogenic? 
Select and explain. 
A. Pyruvate, B. Oxaloacetate, C. Acetyl-CoA, D. Lactate
C: Acetyl-CoA
Answer: C: Acetyl-CoA 
Explanation: Ans: C. Acetyl-CoA(Ref. Harper 30/e p185, 29/e p187)Acetyl CoA is not a substrate for gluconeogenesis (not glucogenic) and cannot be conveed back to glucose."Acetyl CoA is not a substrate for gluconeogenesis and cannot be conveed back to glucosee. This is because acetyl CoA cannot be conveed back to pyruvateQ since its carbon backbone is lost in citric acid cycle as CO2."