This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2019, Subject name: Social & Preventive Medicine
Pneumococcal vaccine PCV 23 polysaccharide has shown the best results in the following people 
Select and explain. 
A. Sickle cell anemia, B. Cystic fibrosis, C. Child less than 2 year age, D. Recurrent otitis media and sinusitis
A: Sickle cell anemia
Answer: A: Sickle cell anemia 
Explanation: - PCV 23 vaccine is recommended for, - Older people > 65 years age - 2-64 years age if they have, Chronic cardiovascular disease Chronic pulmonary disease Diabetes mellitus Alcoholic Chronic smokers Chronic liver disease / cirrhosis Asplenia like sickle cell disease or splenectomy Immunosuppressed like HIV Organ transplantation Renal disease / transplantation - For children < 2 years age, PCV- 23 is strictly contraindicated.