This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2018, Subject name: Surgery
Which is the most conspicuous sign in breast cancer? 
Select and explain. 
A. Nipple retraction, B. Peau d'orange, C. Puckering, D. Cancer en-cuirasse
B: Peau d'orange
Answer: B: Peau d'orange 
Explanation: Peau-d-Orange Peau-d-orange is due to cutaneous lymphatic edema, where the infiltrated skin is tethered by sweat ducts, it cannot swell, leading to an appearance like orange skin. Due to obstruction of subdermal lymphatics (lymphatic permeation by tumor cells) Seen in advanced breast cancer (may be seen in chronic abscess)