This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Benzodiazepines are true in: 
Select and explain. 
A. Produce distortion in sleep more than other sedatives, B. More safe than other sedatives when take in larger amounts, C. After metabolism of other drugs in liver, D. All have metabolically active substrates
B: More safe than other sedatives when take in larger amounts
Answer: B: More safe than other sedatives when take in larger amounts 
Explanation: None