This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2018, Subject name: Pathology
Which of the following cannot be diagnosed without positive ANA? 
Select and explain. 
A. Drug induced lupus, B. SLE, C. Sjogren syndrome, D. Scleroderma
B: SLE
Answer: B: SLE 
Explanation: Repeated negative testing for ANA indicates least chances of having SLE. ANA is positive in 98% of patients with SLE Limited form of scleroderma known as CREST has anti centromere antibody positive and generalized form has anti topoisomerase positive antibody Anti histone antibodies are positive in drug induced lupus Anti SS-A (RO) antibodies and anti SS-B(LA) antibodies are positive in Sjogren's Syndrome