This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
In a 30 years old female patient with polyahritis, testing reveals nucleolar pattern of ANA staining. What is the likely course of this patient? 
Select and explain. 
A. Malar rash, alopecia and renal failure, B. Sclerodactyly, esophageal dysmotility and Raynaud's phenomenon, C. Sjogren's syndrome, D. Painful genital and oral blisters and ulcers
B: Sclerodactyly, esophageal dysmotility and Raynaud's phenomenon
Answer: B: Sclerodactyly, esophageal dysmotility and Raynaud's phenomenon 
Explanation: Answer- B. Sclerodactyly, esophageal dysmotility and Raynaud's phenomenonNucleolsr ANA positivity is most likely suggestive of systemic sclerosis or scleroderma, which comprises of diffuse or limited disease-CREST syndrome (Calcinosis, Raynaud syndrome, Esophageal dysmotility, Sclerodactyly, Telangiectasia)Antinuclear antibodies are directed against nuclear antigens, grouped into: ( I ) antibodies to DNA (2) antibodies to histones (3) antibodies to non-histone proteins bound to RNA (4) antibodies to nucleolar antigens.Most widely used method for detecting ANAs: Indirect immunoffuorescence (identify antibodies that bind to a variety of nuclear antigens, including DNA, RNA & proteins).Pattern of nuclear fluorescence suggests the type of antibody present in the patient's serum.