This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2018, Subject name: Pharmacology
Major determinant of loading dose of a drug is:- 
Select and explain. 
A. Half life, B. Clearance, C. Volume of distribution, D. Bioavailability
C: Volume of distribution
Answer: C: Volume of distribution 
Explanation: LOADING DOSE = Vd * target plasma concentration The loading dose is primarily dependent on the volume of distribution of drugs. The loading dose is administered to achieve rapid action of drugs having high the volume of distribution. MAINTENANCE DOSE = Clearance * target plasma concentration