This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
A new marker for mantle cell lymphoma especially useful in Cyclin DI negative cases is: 
Select and explain. 
A. SOX 11, B. Annexin V, C. MYD88, D. ITRA I
A: SOX 11
Answer: A: SOX 11 
Explanation: Answer- A. SOX 11SOXII expression h a highly specific for mantle cetl lymphoma and identifies the cyclin Dl-negative subtype.Mantle Cell Lymphoma (MCL)Immunophenotype:CD20 CD79a & PAX-5 positive establish B lineageCD5, CD43, FMC-7, cyclin Dl & SOX11 positiveSurface IgM & IgD positiveCDS+ve & CD23 -ve which help to distinguish it from CLL/SLL.