This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2019, Subject name: Biochemistry
Mutation seen in sickle cell anemia: 
Select and explain. 
A. Point, B. Inseion, C. Deletion, D. Frame shift
A: Point
Answer: A: Point 
Explanation: Sickle-cell anemia Due to a single base alteration Point mutation Glutamate at the 6th position of b-chain of haemoglobin is replaced by Valine. UCA (serine) UCU (Serine) CCA (Proline) UAA (Stop codon) Silent mutation Mis-sense mutation Non sense Mutation