This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Dental
Periapical bone resorption occurs due to: 
Select and explain. 
A. IL-1 alpha, B. TNF alpha, C. Both, D. None
C: Both
Answer: C: Both 
Explanation: TNF-α, IL-1, and PGE2 also promote osteoclast activity, particularly in case of inflammatory osteolysis such as those found in periodontitis and peri-apical pathology.
Textbook of Endodontics Nisha Garg 3rd Ed