This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Which of the following is not a characteristic feature of multiple myeloma? 
Select and explain. 
A. Increased Ig levels in serum, B. Positive ANA, C. Plasmacytosis, D. M spike on electrophoresis
B: Positive ANA
Answer: B: Positive ANA 
Explanation: Ans. B. Positive ANASerum electrophoresis: Abnormal spike in the region of gamma globulin (myeloma spike) is present in 90% of cases.* Bone marrow plasmacytosis in multiple myeloma is characteristically more than 30%.* The immunoglobulin least commonly involved in Multiple Myeloma is IgD.* The immunoglobulin most commonly involved in Multiple Myeloma is IgG. - Low haemoglobin, - high ESR (usually very high), - increased total protein, - A/G ratio reversed, - increased serum calcium, - normal alkaline phosphatase. - Urine: Bence Jones proteins are found in 30% of cases.