This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Which of the following hormones will be affected most after the change in sex hormone binding globulin? 
Select and explain. 
A. Testosterone, B. Estrogen, C. Progesterone, D. DHEA
A: Testosterone
Answer: A: Testosterone 
Explanation: Ans: A. Testosterone(Ref Ganong 25/e p 422, 24/e p424; Harper 30/e p 516. 517)Testosterone binds to SHBG with higher affinity than does estradiol.Hence SHBG level change a Greater change in free testosterone level than in free estradiol.Sex hormone binding globulin:Glycoprotein binding sex steroids with high affinity as.Order:DHT>Testosterone>>Esterone/ estradiol. Due to higher SHBG affinity for DHT & Testosterone, SHBG variation has profound effects on androgens levels.