This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
A pregnant, diabetic female on oral hypoglycemics is shifted to insulin. All of the following are true regarding this, except: 
Select and explain. 
A. Insulin does not cross placenta, B. During pregnancy insulin requirement increases and cannot be provided with sulphonylureas, C. Tolbutamide crosses placenta, D. Tolbutamide causes PIH
D: Tolbutamide causes PIH
Answer: D: Tolbutamide causes PIH 
Explanation: None