This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2018, Subject name: Pharmacology
A patient of HIV is on treatment with indinavir, zidovudine, lamivudine and ketoconazole. He developed nephrolithiasis, hyperlipidemia, central obesity, hyperglycemia and insulin resistance. Which of the following drug is likely to produce above adverse effects? 
Select and explain. 
A. Lamivudine, B. Indinavir, C. Zidovudine, D. Ketoconazole
B: Indinavir
Answer: B: Indinavir 
Explanation: Protease inhibitors (-navirs) can cause lipodystrophy syndrome characterized by weight gain, increased glucose, increased lipids and insulin resistance. Lipodystrophy syndrome can also be caused by anti-psychotic drugs. Special side effects of various protease inhibitors: Indinavir: Renal stones Tipranavir: Intracranial hemorrhage Saquinavir: QT prolongation. Atazanavir: Hyperbilirubinemia.