This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2018, Subject name: Pharmacology
Acetazolamide is given to a patient of angle closure glaucoma. It is a non- competitive inhibitor of carbonic anhydrase enzyme. Which of the following should be the effect of this drug? 
Select and explain. 
A. Decrease in Vmax, B. Decrease in Km, C. Decrease in both Km and Vmax, D. No change in Vmax
A: Decrease in Vmax
Answer: A: Decrease in Vmax 
Explanation: Enzyme inhibition is of 3 types: Type of inhibition Km Vmax Competitive inhibition Increases No change Non competitive inhibition No change Decreases Uncompetitive inhibition Decreases Decreases In question non competitive inhibitor is given, so answer is decrease in Vmax.