This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2019, Subject name: Physiology
Which of the following hormone crosses the plasma membrane for its action? 
Select and explain. 
A. Epinephrine, B. Glucagon, C. Insulin, D. Thyroxine
D: Thyroxine
Answer: D: Thyroxine 
Explanation: Intracellular hormone receptors: - - Several hormones, including adrenal & gonadal steroid hormones, thyroid hormones, retinoid hormones and vitamin D, bind with protein receptors inside the cell. - Because these hormones are lipid soluble. Cell surface receptors: - - All the peptide hormones uses it - They are water soluble. - They act secondary messengers (CGMP, CAMP etc.) Examples: Catecholamines (epinephrine, dopamine) Insulin Glucagon Prolactin Growth hormone etc.