This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Injection of Glucagon is effective for management of persistent hypoglycemia in all EXCEPT – 
Select and explain. 
A. Large for date baby, B. Galactosemia, C. Infant of diabetic mother, D. Nesidioblastosis
B: Galactosemia
Answer: B: Galactosemia 
Explanation: Hypoglycemia in hyperinsulinmic state require IM glucagon as treatment.
Glucagon increases glucose level in blood by Glycogenolysis and Gluconeogenesis.
But in galactosemia - Liver is the first organ to be affected, so glucagon will unable to increase glucose as glycogenolysis and gluconeogensis can not occur ion already damaged liver.

Nesidioblastosis :

It is persistent hyperinsulinemic hypoglycemia occurs due to 0 - cell hypertrophy in infant of diabetic mother due to continuous maternal hyperglycemia.
Glucagon is effective in controlling such a hypoglycemic condition.