This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2019, Subject name: Microbiology
For which of the following is PPV-23 is most beneficial: 
Select and explain. 
A. Cystic fibrosis patient, B. Sickle cell anemia patient, C. Patient with recurrent rhinitis and sinusitis, D. Child less than 2 years
B: Sickle cell anemia patient
Answer: B: Sickle cell anemia patient 
Explanation: Repeated microinfarction can destroy tissues having micro vascular beds prone to sickling. Thus splenic function is frequently lost within 18-36 months of life causing susceptibility to infection paicularly by pneumococci. So ( PPV-23) polysaccharide pneumococcal vaccine is beneficial in sickle cell anemia.