This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2019, Subject name: Microbiology
In chronic allergy which lg are more persistent in the body? 
Select and explain. 
A. lg G, B. lg E, C. lg A, D. lg M
B: lg E
Answer: B: lg E 
Explanation: IgE is highly potent and mediates type I hypersensitivity reactions by binding to the mast cells causing its degranulation. lgE response is seen in various allergic (both acute and chronic) conditions, such as asthma, anaphylaxis, hay fever, etc. lgE has : lowest serum concentration, Shoest half-life, minimum daily production, only heat labile antibody (inactivated at 56degC in one hour), has affinity for the surface of tissue cells (mainly mast cells) of the same species (homocytotropism).