This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
A person is HBsAg positive, but Anti- HBc Ab is negative. What should he the next step? 
Select and explain. 
A. Repeat test after 6 months, B. Check HBV DNA load, C. Check HBeAg, if positive sta interferon, D. Reassure patient that he does not have any disease
B: Check HBV DNA load
Answer: B: Check HBV DNA load 
Explanation: Ans: B. Check HBV DNA load(Ref Harrison 19/e p2032, 18/e p2551)Chronic Hepatitis B - Parameters:HBsAg positive; Anti- HBc Ab negative.Presence or absence of serum hepatitis Be antigen (HBeAg).HBeAg-reactive & HbeAg negative.HBV DNA level correlate with liver injury level & has progression risk.Treatment pre-requisites:HBV-DNA load should be done before initiating treatment.