This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which one of the following is a gender-specific side-effect of valproate? 
Select and explain. 
A. Polycystic ovarian syndrome, B. Alopecia, C. Weight loss, D. Tremor
A: Polycystic ovarian syndrome
Answer: A: Polycystic ovarian syndrome 
Explanation: Ans: A. Polycystic ovarian syndrome Side-effects of Valproic AcidMC side effects are transient GI symptoms (anorexia, nausea & vomiting)Effects on the CNS: Sedation, ataxia & Rash, alopecia Stimulation of appetite & weight gain.Increase the chance of polycystic ovary syndrome (PCOS) in women with epilepsy or bipolar disorders Elevation of hepatic transaminases, microvesicular steatosisAcute pancreatitisHyperammonemiaNeural tube defects