This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AIIMS 2019, Subject name: Physiology
Acetyl choline release can be increased from presynaptic membrane by: 
Select and explain. 
A. Blocking voltage gated Na+ channels on presynaptic membrane, B. Blocking voltage gated Ca+ channels on presynaptic membrane, C. Blocking voltage gated K+ channels on presynaptic membrane, D. Blocking voltage gated CI- channels on presynaptic membrane
C: Blocking voltage gated K+ channels on presynaptic membrane
Answer: C: Blocking voltage gated K+ channels on presynaptic membrane 
Explanation: Blocking voltage gated K+ channels on presynaptic membrane | K+ exit stops | Membrane does not get hyperpolarized |Continued Ach release When an AP depolarizes the presynaptic membrane=Ca++ channel open=allow release of neurotransmitter=from terminal=into synaptic cleft=forming bridge for the vesicles and release sites of a depolarized membrane. Blocking voltage gated Na++ channels will block the AP propagation Chloride channels are present=on the post synaptic membrane.