generate questions: Mutations or deletions of clock gene in mice have demonstrated the importance of body clocks to ensure the proper timing of cellular/metabolic events; clock-mutant mice are hyperphagic and obese, and have altered glucose metabolism. In mice, deletion of the Rev-ErbA alpha clock gene facilitates diet-induced obesity and changes the balance between glucose and lipid utilization predisposing to diabetes. However, it is not clear whether there is a strong association between clock gene polymorphisms in humans and the susceptibility to develop the metabolic syndrome.
What is the body clock gene in animals necessary to ensure? {sep_token} What do mice without the clock gene become? {sep_token} Beside obesity, how else does the lack of a circadian clock effect   the mice? {sep_token} How certain is it that these circadian clock  effects are the same in humans? {sep_token} What gene needs to be deleted to cause obesity in mice?