Methotrexate
"I was started on Plaquenil when diagnosed with RA about two years ago at the end of summer.  I told the doctor there was no way I would take MTX.  By the following late spring I had what it took me a while to realize was a major flare-up.  I already had one pointer finger that couldn't bend, and now the other one was stuck in the out position.  I couldn't make fists.  So I started on MTX once a week, along with 1 mg of folic acid/day.  After about two months I began to see improvements.  After a longer time my doctor said I was in remission.  I take both Plaquenil and MTX, with few side effects.  On my MTX day, and the day after, I'm sometimes low energy, and often slightly queasy.  Not enough to keep me from eating entirely."