Estradiol
"I would NOT recommend this patch to anyone. The company has printed in black ink the product name on the patch itself, which is beyond dumb!!  The glue leaves huge circle on your underwear that will not come off. The glue leaves circles on your skin when the patch is removed, which is almost impossible to come off. I used Vivelle before and had none of these problems, plus the patch was half the size as this product. Insurance said this product was a generic and would no longer pay for the Vivelle."