Mucinex D
"I have severe sinus problems all year long, but worse in the fall. The pressure pain is almost unbearable. My doctor has prescribed everything under the sun to help relieve the symptoms and nothing works better than Mucinex D. I never have any drainage with my sinuses...just the pain/pressure and I can get almost immediate relief after I take 1 bi-layer tablet (1200mg guaifenesin and 120mg pseudoephedrine).  The medicine says it has an immediate release layer that works quickly and it does.  Then it has an extended release layer that works over the next few hours.  I also have the side effect of insomnia, but it's so worth it to relieve that sinus pressure (those of you who have it know what I'm talking about!)."