Adapalene
"I have only been using Differin for a few days. I have seen a big difference from other regions I have been using. Today, I had a breakout. Like the one I orginally got that sent me to the doctor. I spoke with the pharmacist. She had told me that this particular medication tends to get worse before it gets better. Being hopeful I am still using my Finacea in the mornings and my Metronidazole topical in the afternoons and the Differin before bed. All the while taking the prescribed medication as well. Also always use an additional moisturizer because these all like to dry your skin out.  Another thing to add if you are on the minocycline and differin both are sensitive to sunlight. So if you go out use a moisturizer with sunblock. Roscea 1yr"