Naltrexone
"I was diagnosed  with MS in Dec 16. Had the most severe fatigue and leg numbness, didn't sleep for more than few hours for years. Had extreme heat intolerance too. After just 5-10 min doing exercise   or work felt like I was going to pass out. All of this combined made me so miserable I couldn't grasp why I would need to go on. Copaxone seemed to help a little but the injection sites were all like a swarm of bees stung me. Researched  Low Dose Naltrexone (LDN )and couldn't believe reviews. Emailed doc and he wrote script without a second guess. Take about 3mg every night around 9pm. 

Life changing decision. No bull. Feel better than I have in 10 years. Heat tolerance in about 90% corrected except for few off days. Energy is much better and tingling mostly gone."