Doxycycline
"Never saw the tick, but saw a quarter-sized rash with a distinct edge on my leg, so went to my doc immediately. Was put on a 2-wk course (100mg twice daily), Dr told me I could take it with food. Then had 2 wks off it (on vacation, and lab took forever to turn around my blood work). Tested positive for Lyme; Dr put me on 2nd 2-wk course. Since it's absorbed better on an empty stomach, started taking it that way. No ill effects, no nausea. However, blood tests still positive. Did a 3rd round; still have Lyme disease. Am now on my 4th 2-week round and am seeing a specialist in a few days. Worried that it's not working, but hopefully I just need a longer course. No side effects other than exhaustion."