Estradiol
"I use the vaginal cream.  I started it a couple of years ago for vaginal dryness during the menopause transition.  I was not properly advised about the dosage - which I had stepped down to 2mg twice a week, and started to menstruate again.  Many tests later, it was determined I was using too high a dose.  I stopped for 4 months or so, but have recently restarted, at a lower dose.  The dryness has improved, but my hot flashes are back.  They had subsided when I wasn't using it."