Lyrica
"I have tried a number of different drugs for RLS, including Lyrica, Mirapex, Klonopin, Neurontin, and clonidine.  Lyrica and Mirapex are by far the most effective medicines for me in treating restless legs syndrome.                                                      
Note: I am confined to a special type of power wheelchair.  My primary diagnosis is Ehlers-Danlos Syndrome; other diagnoses of particular note include Chronic Pain Syndrome, idiopathic polyneuropathy, Schizoaffective Bipolar Disorder, CHF, seizure disorder, severe degenerative bone & joint disease, severe degenerative disk disease, obstructive sleep apnea, GERD;  among others.  I have a colostomy and a suprapubic catheter."