Vortioxetine
"I started Brintellix the first month it came out, after trying numerous other medications over the years; SSRIs, SNRIs, MAOIs, tricyclics, and other classified antidepressants. Those that did help with tolerable side effects lasted maybe a year or even several years.  None seem to do well in the very long term. I worked my way slowly to the 20mg Brintellix dose and very helpful without noticeable side effects.  I do require a small dose of an atypical antipsychotic to control the suicidal thinking, currently Rexulti.  Recently, my doctor increased Brintellix dose to 25mg and doing much better again. Prior to that, I lacked desire to do things, anything.  Now very active again. I've had no adverse effects from this medication. Time will tell"