Clozapine
"My son has been on Clozaril for 3 years. He was dx with Bipolar when he was just 6 years old.  He had literally been on every anti-psychotic drug until his 7th hospItal stay, his regular psychiatrist and the hospital's Dr decided to try this medicine. As far as his psychosis it has been a wonder drug. But physically, Clozaril is destroying his body. In the  first 6 months, he was dx with asthma. The worst of his problems that developed in the past 9 months has been GI and liver. He now has severe ensephagitis, gastritis, 4 ulcers and NAFLD (fatty liver disease). He has also gained over 50 lbs. Not just teenage pounds. I was also told when he started the Clozaril, it isn't really approved for patients under 18. Too late now."