Venlafaxine
"I have tried everything I can read about to alleviate hot flashes. I'm 47 and have had them for years but still have regular period so I can't try HRTs yet. Nothing over the counter has ever worked. What has worked for me (birth control, Effexor 37.5 & Effexor 75) work for about a year and then the hot flashes come back as strong as ever, all day every day. I'm scared to up my Effexor to 150. Right now, I am trying combination birth control and Effexor 75. It's been a week and no improvement yet.  But Effexor did work for me and I'm thankful for the years it did. I had no side effects. It helped my anxiety too."