Guanfacine
"This is by far the most effective medicine I have taken for high blood pressure. As another poster said, it needs to be taken with caution at first until you know what dosage is right for you - it can bring your pressure actually low at low dosages. I have found it to have far less side effects than clonidine. It is a long lasting medication able to be taken once a day - I take it at night, as it helps with sleep and by morning any sedative effect has worn off, leaving me with a feeling of well-being. I have not noticed any increase in appetite, but being diabetic I have noticed a rather serious increase in fasting blood sugar which will require tweaking of those medications. Metformin offsets that side effect in a beneficial way."