Duloxetine
"I'm a 74 year-old woman who has had peripheral neuropathy for about 7 years. None of the meds prescribed gave me any relief until I was started on Cymbalta. It seemed miraculous, as within a week or so I had almost no pain or burning in my legs and feet. I'm on 60 mg daily, along with oxycodone (7.5 mg twice daily). In the last couple of years the Cymbalta is far less effective than it was initially, and I would have even more pain if it weren't for the oxycodone. I asked my doctor about increasing the Cymbalta to 90 mg, but he says you don't get much more relief beyond the 60 mg dose. It's very disappointing to have the effectiveness decrease. Side effects are weight gain and sensitivity to heat and sweating."