Tramadol
"I was put on Tramadol for pain and a funny thing happened.   I noticed I felt more energy and overall well being.   I had felt a bit depressed over the years and they tried a few meds but none seemed to work.   I had surgery and was given tramadol.   Once the pain was gone - I stopped it and noticed I fell back into my old slump.   I was in therapy and tried everything.  Years later  I went to Mexico for business and saw Tramdol in the pharmacy.  I bought one bottle of 50mg capsules and said let's try this. 50mg twice a day.  Within 2 weeks people were commenting I seemed like I was happier.   It does not give me a high like hydrocodone and other opiate meds.   They need to explore this and stop shooting it down as an antidepressant."