Colchicine
"I used to get gout in the past. Mainly in my big toe, occasionally severe - meaning I could not sleep, or walk. Basically - when it was at its worse - it was a living hell. I was prescribed a preventative (probenecid?), along with pain meds. Then I was given Colchicine. The way I was prescribed it was  unusual - I was told to take a pill every hour until I became sick!  Well, about 6 hours and six pills later - I slowly became ill, had the runs, was throwing up - felt like I had the flu. But, after all that nastiness passed, amazingly the pain in my toe was gone! It seemed to have been flushed from my system. My toe was still red and itchy, but the pain was gone. It was amazing! Ultimately, the side-effects were surely worth the relief!"