Glimepiride
"Diabetic for 7 years.  Started with Metformin only.  Then added Starlix with meals.  Small improvement with post-prandials.  Exchanged the Starlix with glimepiride.  Have been on glimepiride for 2 and a half years with meals.  Does not prevent my spikes but does pull them down within a short time. The sudden drop makes me feel low when I am just "dropping" FAST into the normal range.  The problem is the time it remains in effect will cause me to be low (50;s) during the night while sleeping if I take with last meal of day.  Without it, I skyrocket after eating and slowly come down.  My doctor is taking me off of glimepiride because of the lows while sleeping and will put me on another med.  My A1C's have been climbing over the past year."