Clonidine
"Been on 0.1mg three times a day for 10 days now and it has made a HUGE difference in my detox from heroin, oxycodone, and hydromorphone. Almost completely eliminated the agitation and restlessness which has always been my personal least favourite symptom of opiate withdrawal. I highly recommend anyone suffering from an addiction akin to mine to talk to a doctor about getting on it, I finally let my family doctor know about my 3 years of on and off use of various opiates and it was his first suggestion. I am also on propranolol and amitryptiline which I started at the same time as the clonidine. The only downsides I have experienced are a certain degree of daytime drowsiness and blood pressure drops upon standing up after lying down."