Linaclotide
"For as far back as I could remember I always had issues going to bathroom. constipation. Bloating. Straining just for "pellets". I tried numerous over the counter products from powder forms to pills and they Did not work  at all and caused more severe bloating  and cramps. I found out I have colonic intertia. I had the strongest dose prescribed to me of the linzess and found that if I take it on an empty stomach 30 min before I eat dinner after I'm done eating id say 30 min to an hour I'll feel  some pressure but no pain and know it's time to head to the bathroom and it cleans me out. I usually have maybe 2 small bathroom trips after and then I'm good for the nite. I usually take it twice a week not everyday or as needed to go to bathroom."