Prednisone
"I came down with a fever and severe sore throat over the weekend.  Felt like I was swallowing glass.  Finally went to the doctor on Sunday and was diagnosed with strep throat.  They gave me antibiotics and prednisone.  Took my first dose at 7pm Sunday and woke up Monday feeling about 80% better.  By Monday evening throat has almost zero pain.  Amazing.  However it is midnight and I can't fall asleep and just want to get up and clean out a closet so that might be a negative.  I will take it over the glass throat though.  :)"