Topamax
"I have never had the feeling of being full and have fought obesity since childhood. I had a successful gastric bypass in 1980 (but with serious lifelong medical complications) and lost 170lbs at after the operation.  Over the years I've gained and lost up to 70lbs but never held a steady weight. I saw a psychiatrist 6 years ago (for other reasons) and shared this with him.  He told me about Topamax and explained that it did not work in everyone, but had with some of his patients with true food disorders.  He started me at 5mg/day  and increased the dosage by 5mg/ week.  When I reached 150mg/day I noticed that I consistently pushed my plate away or stopped eating when I was full. It has been a miracle, and my weight hasn't varied more than 5lbs in 7 years."