Valerian
"I have Rheumatoid Arthritis, an auto-immune disease. Valerian was recommended to me for insomnia and so I took one. Because of my compromised auto-immune system, the pill had the opposite effect. I felt as if I had been given epinephrine and was in a 'run' mode all night long. By morning, I was exhausted and my head felt like it was about to explode. 
People with auto-immune disorder should definitely  stay away from this herbal pill."