Enbrel
"I have had rheumatoid arthritis for 31 years.  During this time, I went through all the medicines given me.  They might work somewhat for a few weeks, but then would fail or the side effects were too severe.  I have been on "gold" injections (5 years) and Metotroxite, and Predisone for another 5 or 6 years.  Eight years ago, I went on Humira for a few months.  It was helpful only for a few days and then the rest of the week was too painful.  I then switched to Enbrel, at first 25 mg twice a week, and now 50 mg once a week.  It has been wonderful - I still have joint soreness if I over-do, and  need to take a muscle relaxer at night, but I am so much better.   I worry that it may start to be less effective, but so far, I'm loving it"