Mesalamine
"I was diagnosed with crohn's disease when I was 27yrs old. I'm now 54. Ive been through 2 fistula removal's and many nights awaken with extreme rectal spasams. no fun! Extreme weight loss and fatigue. My Dr. put me on Asacol 400mg (2 in the morning, and 2 at night). turned my life around. Dr. told me I needed to stay on the medicine for rest of my life. I felt great, put weight back on and then I did a stupid thing. I decided to stop taking it. was doing fine for past 5yrs but its back. weight loss and all other symptoms, cramping, loss of appetite, etc..   If Asacol is working for you, stay on it."