Isotretinoin
"My face was horrendous before I used (ro)Accutane, to the point I couldn't see out of my left eye due to the level of spots/boils I had swelling up and becoming one. I noticed a difference on Accutane after a month or so, but the real improvements start after approximately 2 months depending on how bad you have it (mine was really bad and aggressive). I would definitely recommend reading the book of side effects you are given, I am "lucky" as I only really suffered with depression, which as most of us know you do so if you have acne anyway. One recommendation is not going in direct sun light until a month or so after finishing the treatment, and finding a very good face and lip moisturiser and these 2 parts will become very very dry!"