Hydrochlorothiazide
"I am completing my 5th year of taking 25mg Hydrochlorothiazide -  with 1 tablet daily each morning, at times taken with and at others without food.  In such respect, I am not aware of having experienced any noticeable effects - positive or negative - at any time.  In year two, I came off the medication for some 20 days.  CVS renews the 90-day prescription refills with automatic reminders.  I happen to delay for more than two weeks with my picking up that refill but experienced no discerning effects with my sudden stopping or upon renewing the daily dosage."