Linaclotide
"I have been taking Linzess 290 for about 2 months for severe abdominal pain due to irritable bowel syndrome with constipation.  From the start of taking it, I have had no further episodes of abdominal pain or constipation.  If I don't take it for one day, I start to feel very unwell again with abdominal cramps.  I find that once I take it, I need to be near a bathroom within a couple of hours but after 1 or 2 bowel movements, there are no more.  To be free of the severe cramps that were so bad that I would be sick to my stomach and almost pass out from the pain, is such a relief and has improved my quality of life immensely.  The pills are expensive though"