Lubiprostone
"I have taken two doses and it didn't work at all. Was it placebo? I have no idea. What happened was that I experienced strange psychotropic effects: lessened ability to judge distances, lessened ability to follow conversations, slower reading speed, headache, facial muscle spasm, clenching my jaw, and then a crying episode after 4-5 hours after the dose. At least I know it didn't cause my acne.

I am scared to try the higher dose after reading everyone's comments and the fact that my blood pressure runs low to begin with. And the fact that my stomach is prone to nausea."