Isotretinoin
"I had to rate Accutane highly, as it did exactly as advertised. I lived with chronic cystic acne for most of my teenage years, and went on Accutane at 20. Six months of treatment, and my acne was gone. I'm 37 now, and have not experienced any long term side effects other than having my acne cured. I tried many medicines to treat the condition, but this one flat-out cured it. I would not have thought it possible."