Niacin
"I have suffered with moderate to severe depression my entire life.  Last August, after 9 years on Effexor, I stopped taking it because of the side effects.  

I tried using supplements as recommended by  Julia Ross in her book The Mood Cure, but they were not effective for me.  My depression became so severe last Oct. that I had to go back on to an anti-depressant (Bupropion) but this medication made my depression much worse.  I was then put onto Trintellix in April.  The Trintellix was helpful, but side effects soon began to appear.  

I happened upon an article about a psychiatrist who had used niacin for treating depression.   When I googled niacin and depression, I came upon many other blogs and comments from other people who also found niacin to be effective against their struggles with depression. 

 I was desperate to find an alternative to taking anti-depressants, so 4 weeks ago, I began supplementing with niacin plus vitamin C.   (I had already been taking a vitamin B multi, magnesium, fish oil and Vit. D).  I started with 100mcg niacin and have been gradually increasing the dose by 25mcg increments each day.  I use only the regular niacin, not the timed release nor the non-flushing type.

Since I started taking the additional niacin & vitamin C,  I find that my depression is/has diminished significantly.  I am no longer suffering from that bottomless well of depressive  feelings that had been with me since last fall.  I stopped taking the Trintellix  3 weeks ago and my depression has continued to lift."