Lubiprostone
"I've been chronically constipated since I was 5 (I'm in my early 20's now). I always went to Doctors, who kept saying over and over "fiber and water." Prune juice and normal laxatives (not stimulant laxatives) would have little to no effect on me. Amitiza makes me feel normal, and for the first time I can ever remember, I don't dread when I have to do a bowel movement. It's painless! I've solved this taboo problem that I have suffered with for my entire life! Its a great feeling to have relief now. I do get nausea and a headache if I take it without a moderate sized meal. I also get cramps and explosive diarrhea if I take it and then eat a lot of dairy, like a milkshake (I'm not lactose intolerant though). Despite this, I love this medicine!"