Venlafaxine
"I've been taking antidepressants for about 15 years, due to panic attacks, general anxiety, and situational depression, and they have worked well. Additionally, for 10 years I have had very severe leg pain, seeming to be sciatica/nerve pain and muscle pain, from hips to feet. I was told by two orthopedists that, "You're just old (59) so live with it." 

It's been only a month since I changed to SNRIs--namely Venlafaxine--and since the very first day, I have been pain free. I can walk again with long strides and quickly. I can stand for long periods. I can take hikes. I hadn't been able to do that for 10 years.. My life is no longer dictated by how much pain I can endure. I don't know how it works, but I wish I'd known about it years ago."