Glipizide
"Type 2 since 2008 and started on metformin with great results. Over the years the metformin has been progressively increased to the max dose to maintain my A1c at <7. Metformin has now lost its effect and my last A1c was 10.1. Doctor discontinued the metformin and started Januvia 100 mg and Glucotrol xl 2.5 mg, gradually increasing to 20 mg/day. Nothing! The new combo has had absolutely no effect on my blood glucose levels. My FBS are >170 every morning and 2 hr PP around 240! My next drug is the non-insulin injectable, Victoza. I so wish it could be different."