Tamoxifen
"The wisest decision I can share is changing WHEN I take the tamoxifen.  I decided that sleep was imperative in order to deal with the side effects. I take the tamoxifen during the day I live in CA so temp- wise this is a good thing to do. Running hot is an understatement. Skin and hair have taken a hit as the hips have improved.  Suspect no juice to connective tissues is the reason also arthritis has shown up in both knees.  One perk? Evenness of mood after 2 years.  My 10 rating?  No recurrence as of 2.5 years."