Estradiol
"I am 60 years old and have been using Climara 50 patches since 2008 (9 years).  It has definitely relieved the night sweats and the constant anxiety feeling.  I have tried a couple of times to go on a half dose but the symptoms resume, but I will try again. I have never had problems with the patch itself.  The edge can be a little sticky when I put it on, but I always wipe a smear of talcum powder around it to prevent it sticking to my clothes.  I now have a serious hearing problem (not resolved) so of course I'm concerned that it may be connected with this medication, but six years ago I had a massive amount of antibiotics for a staph infection following surgery, so of course this could be the cause."