Spironolactone
"I am a mid twenties female and I have struggled with acne my entire teenage-adult years. I was desperate for clear skin, but not desperate enough to go on accutane. I had to beg my dermatologist to put me on it, b/c she only wanted me to do accutane. Needless to say 4 months and I was still having breakouts, my derm. increseased to 50mg 2x daily and that did the trick. I had NO ZITS for the first time in my life I had clear skin. I was on spiro for 1 year. BUT then, I wanted to get pregnant. So I had to go off of it. First 3 months, I was in the clear no acne. Then BAM, it came back. Not only did it come back, but it came back SO much worse than before. DON'T do it, I know you want no acne, but this is not the solution."