Duloxetine
"This antidepressant literally saved my life. I had tried every other medication for bipolar depression, and nothing worked, not even a little. Then after 2 weeks on Cymbalta, the feelings of worthlessness and hopelessness subsided, my mood changed dramatically for the better, I could actually concentrate, and I've had no problems with taking it after a solid 2 months. I would call this a miracle pill for those with unmanageable bipolar depression."