Doxycycline
"I am 31 and have had acne for my whole adult life. Frustrated, I went to the dermatologist and she prescribed Doxycycline twice daily with a night time cream (Tetrinoin). You MUST take this medicine with food or else you will feel extremely nauseous. You can't take it with dairy or within 2 hours of a multi-vitamin. It has been about a month and I have noticed improvement in my skin, although maybe not as much as I would have hoped for."