Linaclotide
"Linzess has been wonderful for me. I developed a bad fissure and the over the counter options weren't working unless I didn't need to leave the house. With Linzess, I take it at 530, consume something at 600, and about 730 I'm finding relief. For me, it takes only 2 times, 15 minutes apart to feel empty, and then I'm okay the rest of the day usually. I've been able to tailor these bathroom trips around my schedule, and my fissure is finally healed without surgery.  I haven't had any side effects as the watery stools I greatly appreciate. I love this stuff."