Trimethobenzamide
"This is the only drug that makes it possible for me to drive long distance or function due to the nausea I get when I get migraines. No other motion sickness medicine works, and I've tried everything.  I never go anywhere without it. When they quit making it for a while, I had to use suppositories and they worked too, just not quite as long or completely. I hope they never quit making it, I would be in trouble."