Minocycline
"I am a 24yr old female, I've had moderate acne since I was 13. I'm along with the many of you who have tried everything... 
I've done two rounds of Accutane (17yrs and 22 yrs) which cleared up my skin for about 1.5-2yrs. However, this time I started breaking out worse than ever. I didn't want to go back on Accutane due to the cost and responsibility (monthly blood work, monthly derm. visits, monthly pregnancy tests, copays & cost = nightmare) so I was recently put onto 100MG twice a day in addition to topical Aczone (am) and Tazorac (pm). 

I have only been on it for a week, and so far and have noticed no huge side effects other than dry eyes and a little unusually tired. Nothing extreme, we'll see how it goes."