Prednisone
"My husband has a disc bulge in his neck and osteoarthritis in his neck. He suffers from daily chronic pain and severe migraines ranging from a 3 to a 10 . With 10 being the worst. He has taken opiates, NSAIDs, anti depressants, anti convulsants, topical cream, done physio massage botox trigger point ims  chiro..... this has been going on for years. Yesterday he started on 50mg prednisone (3 days) and his pain was down to a 2 last night. Today he is like a totally different man, skipping and smiling, getting ready for work (this never happens as he dreads work because of the pain and misses at least one day a week). I asked him where his pain was (scale of 1-10) as is our normal routine in the morning. He looked at me and said  zero."