Tramadol
"I have had severe RLS for 20+ years and it is absolutely a miserable way to live.   Not only is it miserable for the person suffering, it is miserable for any spouse / significant other that you may sleep next to.   11 years ago I was trying to fall asleep, moving and stretching my legs constantly (to no avail, of course) and my husband threw himself in my face screaming "STOP MOVING YOUR LEGS!!!"    That was when I knew I needed to find something that would help -- after trying several different things - all unsuccessful - I tried tramadol.   It has saved my marriage, it has saved my sanity, and because of those 2 things it has most likely saved my life.  For me, tramadol WORKS for RLS."