Sulfamethoxazole / trimethoprim
"I have been taking Bactrim for about a year and a half now. Prior to Bactrim I took everything else. I've had acne since I was roughly 15 and am now 23. Everything I took either left me feeling crappy, or didn't work. In my experience taking Bactrim the first 2-3 months my face breaks out horribly. Then at some time in that period it just goes away. It is absolutely the best acne medication I've ever taken! I have taken it twice."