Venlafaxine
"I've struggled with depression since I was a teenager (and attempted suicide then). In college I started having panic attacks. A few years later I was put on this new medicine called Effexor (after getting no relief from Paxil nor Zoloft) and for the first time in my life I felt relatively normal!  I've been on Effexor - 150 mg/day for 20 years now and it has REALLY helped me to function at a high level.  I have gone off it several times - VERY slowly, but each time, a few months after being completely off, BANG - unbelievable depression, and I'd go back on. I'm at peace knowing I'll most likely be on it form the rest of my life.  Helps with depression AND anxiety.  No problems drinking while taking it, had three healthy kids while on it."