Venlafaxine
"Effexor might have saved my life because at the time I was given it I had damn near given up hope.  Paxil and Zoloft did nothing. Depakote attacked my liver. Lexapro made me numb. Then Effexor was given to me. 2 weeks after taking it I felt better. 4 weeks later, I was back doing things again. Within a year I had all my interests and hobbies back. 

Cons:

1.  Withdrawal is terrible. When I miss a dose I feel it. Neck pain. Headache. 
2. I've found that I had to increase the dose after two years of usage 75 mg 3x times a day holds me.
3. Not really a con, but when more stress then usual I relapse for a few days with depression but it goes back to normal if you increase dose for awhile."