Adapalene / benzoyl peroxide
"When I first started using epiduo (roughly 2 years ago) I really struggled with dry, red, cracking skin. I was worried about the reaction and read a lot of reviews, many of which said "the redness and dryness stick around for 3 months and after that it works perfectly". In my experience, this was exactly right. After 3 months of the dry, cracking skin, my skin had adjusted and I had far fewer (and less severe) breakouts. At the time I was taking Doxycycline which eventually became ineffective and I've since been on the contraceptive pill for roughly 1.5 years. Epiduo is excellent for preventing small, bacterial pimples and my skin is noticeably worse when I don't use epiduo for a while."