Prednisone
"Have had clusters for 45 years, remember the first one. Ergotamine inhaler worked almost instantaneously but gave me a nasty depression. I take prednisone 2(10mg) at breakfast , 1(10mg) at dinner. Tried taking less and headaches come back with a vengeance! They mess with my digestive tract some , and sharp increase in appetite, and an increase in sexual desire. It is not supposed to do that. I will stay on this medication till the cluster cycle ends"