OnabotulinumtoxinA
"I was a basket case.  Had the sling (we all know how THAT went - grew in to my uterine wall and had a full hysterectomy with some still left inside), Detroit LA, Vesicare - first 5mg then 10mg then doubled up on the 10mg (THAT got my GP's attention. Referring me to Uro-gynecologists where I FINALLY had a concrete diagnosis of a spastic bladder (was always told I had a prolapsed bladder!).  Botox or permanent cathater were my only 2 options.  Botox it was!  Besides an excruciating experience with the injections  (the Dr. RINSED out the lydocaine half way through the process because she saw "debris" in my bladder and didn't re-apply), it's been 6 days since my injections and I literally feel THE BEST I've felt in years!"