Carvedilol
"While being care giver for my dying husband I rarely remembered to take BP meds.  One day I felt terrible and checked my BP.  It was 120/111.  Trip to doc.  Put on increasing doses of Carvedilol, up to 25mg twice a day with zero results.  Lowest BP 147/89 usually 190/86.  Do not feel this is working and have asked doctor to try something else.  Problem is systolic is  much higher but diastolic is not.  Doctor says my heart is good and lungs clear despite having the flu.  I am 82 years old.  Had a stress test two years ago, which was perfect.   I am hoping she may add something to bring down the systolic.  I have had few side effects"