Levothyroxine
"I have been taking .075mg for at least 2 years.  No bad side effects.  No weight gain or loss.  I would say the only difference I notice is no more afternoon fatigue.  This medicine takes awhile to start working.  I do believe it should be taking as said.  (  half hour before meal ) which I don't always follow. My dose has recently been increased to 0.1 MG.  I am going to do my best to follow the directions now....half hour before meal at breakfast."