Desvenlafaxine
"My doctor replaced Prozac with Pristiq in hopes it would be more effective in fighting my depression.  At first I thought I was in heaven.  I'm in my late 50's and never felt this good ever.  I also lost 30 lbs!  As time passed, I became more and more manic. (not a feel good manic either).  Had to get off of it.  Shame.  When it was working for me it was better than anything I've ever tried."