Lisinopril
"Been on medication for hbp for 7 months (also taking Bystolic). Had a reaction of angioedema where my face swelled and then a few days later got hives on my arms and legs. ER doctor explained it's technically NOT an allergic reaction (i.e. not histamine related) so benadryl will not help with the swelling. Given predisone and also taking tylenol. He told me the drug can be taken for decades without any adverse reaction, and then one day, you suddenly get swelling. Having a reaction rules out using any of the ACE inhibitor drugs. Too bad - it was working really well for me. On Cardizem now."