Zonisamide
"My migraines started suddenly at age 52 have no idea why. I  have tried several different medicine including topomax I am now taking 400 mg zanisamide as first preventive and starting another new medicine this next week to see if it will help the head pain. I  get daily  migraines  scale 3 -5 on a average  and can increase at anytime through the day to  6-7 at which time I have to take  a treximet or wait  to see if it passes, sleep, ice quite what ever I  can  do  till it goes away. I  have also tried botox that didn't work either"