Clindamycin
"I will concur with everyone on here that is recommending the water, no lying down within 30 minutes after taking your current dose (try not to take it right before bed) and taking probiotics to help stave off GI issues. These three actions are they holy trinity with taking this stuff - I cannot stress that enough. My first night taking it I forgot about the aux warning of "do not lie down within 10 minutes of taking this drug" (I recommend 30 min) - extreme heartburn ensued. Lots of water and yes, do eat; you will have a better experience. Note: "a lot of water" = at least a cup or two of water (8-16 ounces)."