Desipramine
"I’ve been taking desipramine (the generic from Actavis) for depression since 2003, returning to it after trying many other meds.  It’s the only one that helped, although high doses caused shortness of breath, low-back pain, nightmares, stress, and anxiety.  The key has been finding the correct dose.  An important discovery was that chocolate produces a synergistic effect.  Taking it in the evening right after a large serving of dark chocolate and 10 ounces of milk allows me to keep the dose and prescription costs low.  It’s not nearly as effective without chocolate during the day.  But a problem is that it’s addictive.  Increasing the dose made me more depressed but going down improved my mood, so finding the optimal one has been difficult."