Trintellix
"Subtle, but highly effective. Combine 5mg with 30mg Cymbalta. I was on 60mg Cymbalta, titrated Brintellix to 10mg, but experienced discomfort  (heightened anxiety and weird burning feeling.)  I lowered Cymbalta dose to 30mg a day, an immediate relief from the anxiety. However it crept back,  and I concluded it was an interaction leading to accumulation of Brintellix and went back to 5mg of it. Now after three months I start to get used to that it actually works. Only discomfort is occasionally feeling nauseous (after eating sweets  or pastry on an empty stomach.) 60mg Cymbalta helped me for years with depression and anxiety, however leaving me foggy. The new combination is totally unnoticeable except from making me calm and happy."