Estradiol / norethindrone
"Had been on other HRT meds for hot flashes and irritability, and only gained weight and felt depressed.  Once I started Activella, I immediately felt better on all fronts.  I could sleep soundly, hot flashes gone, mood was good, and I stopped gaining weight.  I have been on it for one year and wish I had been put on it to start.  It is the perfect combo for me.  All other interventions were misses, this was a hit!"