Isotretinoin
"After hearing about the horror stories, I was hesitant to try Accutane. I tried Minocycline (Solodyn), Doryx (Doxycycline), and Bactrim DS. The only thing that was pretty good at clearing was Bactrim DS. Bactrim worked best, but was not working anymore. I had no choice but to go with Accutane. It was a little drying with the eyes initially and my lips still get dry. What people fail to mention is that your body adjusts to the side effects and that you won't have an initial breakout if you start low. I started at 40mg. Going to 60mg this month (my second month). Don't forget, Accutane takes between 2-4 months to see clearing. Good luck! :)"