Depo-Provera
"I've been on the Depo-Provera injection since the 1994 inception of off-label use for Endometriosis. For the last few years I've started having some side effects over the two - four weeks prior to each injection including severe fatigue and hot flashes.  I'll take those side effects any day compared to how I lived when my "Endo" ruled my day to day life.  I've been pain free for years as a result of the 15 years of Depo injections. Other side effects?  I guess we will see."