Mirtazapine
"Have tried mirtazapine twice in the past year after trying many different SSRI's which I just cannot tolerate/take anymore. I was prescribed it for depression and anxiety. After about 2 weeks I noticed a decent improvement in depression.  However, now after a couple of months, I am increasingly more irritable, anxious and panicky which is worse than the depression. This is why I originally went off of it before and this time was no different. I also suffer from insomnia, but the mirtazapine only helped me fall asleep the first week or so, then it just stopped helping once it was totally in my system and now I have trouble sleeping again. Am weaning off of it as I hate the way I feel angry and anxious all the time when on it."