Indomethacin
"This drug is a LIFECHANGER!  I see that others have had some bad experiences, but for me...it takes me from excruciating...nearly unbearable pain, to near-total relief within hours.  Yes, there's something very edgy about it...and if not taken carefully, with food...it can scramble your head for a while.  But for extreme gout attacks in my toes...and some kind of terribly nasty shoulder inflammation and searing pain...it has been, by far, the most effective medicine I have EVER taken.  And, I have some experience with painkillers.  I take Heavy duty narcotics for ruptured discs in my back that barely take the edge off that pain...and do nothing for gout attacks.  Indocin has taken me from not being able to walk...to running, in an afternoon"