Morphine / naltrexone
"When I started taking this Rx, I found it much more reliable than my previous chronic pain med, fentanyl patches, which did not evenly alleviate the pain over the 3 days each patch was supposed to be worn. The patches would work well over the 1st 2 days, give or take, but their effectiveness was noticeably weaker on the 3rd day. Unlike my experience with oxycontin, the pain relief from this Rx generally lasts pretty close to the 12 hours it is supposed to, in time for the next dose. I believe the naltrexone inhibits the marked euphoria as felt on the first day of a fresh fentanyl patch or when taking a short acting opioid like vicodin or percocet."