Clozapine
"I am a male aged 48.  I was diagnosed with Type I Bipolar Disorder when I was 26.  In 2008 it was changed to Schizoaffective Disorder, Bipolar Type.  I had been on Depakote from 1994 until 2014.  The Depakote caused massive weight gain (I topped out around 240 pounds on it).  In April of 2014 the psychiatrists decided to try Clozapine (Clozaril) and discontinued the Depakote.  I lost around 70 pounds over 8 months.  I now weigh 160 pounds.  This is my normal body weight.  The Clozapine has been an excellent anti-psychotic and it works very well.  Even better than the Depakote.  The psychiatrists augmented the Clozaril with Metformin, which studies show can help lead to weight loss.  I am as happy as I have ever been on the Clozapine."