Fentanyl
"I currently wear 50mcg/72 h patch.  Have been on this same dose for 1 year.  Prior year began with 100mcg, then 75mcg,  then 50mcg.  Last few months my left knee down to my foot swells ENORMOUSLY.   Went to E.R. couple months back and they weren't able to give me a definitive answer.   The only relief from this swelling is to take the patch off.  Problem in doing that is my pain comes back with a vengeance!  This patch literally changed my life for the better. Simple tasks use to be impossible.  Now I may have to give it up!  Anyone else with this issue?  Suggestions?"