Propofol
"I had my colonoscopy two days ago and the propofol was excellent at knocking me out and I was awakened by the nurse in my recovery cubicle. I felt pretty good as I woke up, mostly relieved it was over. My only issue with propofol is the extreme fatigue I'm still feeling. I have no energy and not too much of an appetite either.  The drained feeling is quite similar to the lack of energy or enthusiasm one feels with depression. I was given propofol once before with another procedure and had the same reaction. I may be someone who doesn't process the drug out of my body quickly, but I have heard others say the same thing. I'm forcing myself to eat as I know the suprep I was given for prep for the colonoscopy drained me and that may a factor."