Plecanatide
"Been having constipation for over a year due to autonomic neuropathy, I was only going perhaps once a week or less and than it was a small amount. I was diagnosed with gastroparesis and put on that medication. The constipation continued. Went back to the Gastrologist who prescribed this medication. 
On morning of the 9th day (8 days of taking med) it finally kicked in, filled the pot, twice that day. 
However, constipation continued to point I had blockage. 
I have had no relief since day 9, have used for 6 weeks so far.
I take the med same time each day.
Its like taking nothing, again.
I have started experiencing headaches, unknown if related to this particular medication or to the autonomic neuropathy.
Will be returning to dr for other ideas."