Tamoxifen
"I've been taking Tamoxifen for 10 months now.  At first, I seemed okay.  The doctor prescribed Effexor at the same time to combat any menopausal symptoms.  I fell into a bad funk.  SEVERE depression and not sleeping.  I stopped taking the Effexor (doctor wasn't too happy) thinking that was causing some adverse effects.  He put me on Trazodone 50 mg for sleep. That worked for a short period of time so they upped the dosage to 100 mg at night.  However, my depression is tenfold.  I'm so irritable and angry all the time.  The slightest thing sets me off.  I can't stand to be around people.  I can't concentrate and my appetite has decreased.  I've lost about 8 pounds. I just don't feel right, ever, anymore.  I have to stay on this for 5 years."