Tranylcypromine
"I give it a 10 and I would give SSRI's and SNRI's only a 5. It's our first experience with MAOI's and its still early days. But what a difference with fatique (none). Other side effects in our case are minimal or non existent. I wonder what % of people actually notice severe side effects (maybe less then 20%?). It appears that MAOI's are well known these days. I presume it's because they are old generic drugs (not covered by active patents) and hence will not get high advertising budgets from the pharmaceutical companies. I also presume that many GP's have no knowledge of this class of drugs or these are too risky, adverse (side effects) to recommend a trial. It took us at least 7 years of battling depression and fatigue before we found out!"