Mirtazapine
"I have fairly severe anxiety and depression, as well as some insomnia. I've only been on this medication for a few days. I have tried Lexapro, Buspirone, Zoloft, Gabapentin, Trazadone, and Topamax. I was on Lexapro for about three years and it worked wonders. All of the others either had little to no effect or had terrible side effects. I am now coming off Zoloft and starting Remeron (mirtazipine) combined with Effexor Xr. Although I have not been on it long enough for it to improve my mood, I have noticed that it makes me feel almost zombie like. It helps me sleep, but I have to force myself out of bed and I am constantly tired throughout the day. I am going to give it some time and see how it goes."