Venlafaxine
"I had a friend tell me about Venlafaxine and how it helped her hot flashes. I'm so happy I took her advice! Not only did it eliminate my hot flashes it improved my mood and took away the irritability  I had. My husband calls it my happy pill. It's so nice to not have the hot flashes and feeling so irritable.  This was a much better choice for then taking hormones! I've had to increase the dosage over the last year to 150 mg."