Linaclotide
"I used to have to use an enema 2-3 times a week, but now I take 145 microgram capsule with hot coffee in the morning. After about an hour, this usually results in several trips to the toilet. But (no pun intended), once I'm done, I'm done! Waiting for the BMs to finish is a pain in the bottom, but overall it works for better for me."