Belladonna / opium
"This medication worked amazingly. I have a chronic pain condition called "Interstitial Cystitis", also called "Painful Bladder Syndrome", and I take a slow release opiate every 12 hours, and an immediate release opiate medication for breakthrough pain. This medication reduced breakthrough pain instances to around 5% from 40-50% of the time. Unfortunately, it is not FDA approved and my new insurance won't pay for it, which is a huge bummer. 

One of the benefits was that since it was a suppository, it stayed local and I didn't feel drowsy from taking it. I really wish I could still get it. I made a 30 day -60 suppository prescription last by not taking it at night since I felt my night regimen was working fine and I was asleep."