Vortioxetine
"I am having such a hard time with anti depressants (low tolerance).  I have been on Trintellix for 6 weeks-started on 5 mg currently on 10 mg.  From day one I have had severe side effects: constant nausea, headaches, diarrhea, extreme fatigue, weakness, and restlessness to name just a few.  My mood has been so bad, wanting to crawl out of my skin, crying and very agitated and hostile.  

My constant nausea has finally stopped but now I can't eat anything as I feel sick.  I am stopping taking Trintellix as I am concerned about how angry I have become since being on this drug.  I am angry at anything and everything.  Have never had this kind of reaction to any of the other ADs and am worried about how intense the anger is."