Lubiprostone
"I have suffered with chronic constipation for the last 9 years- it has got got progressively worse and I have literally tried EVERYTHING treatment and drug wise and nothing works anymore. I only pass BM when I have a weekly colonic irrigation which even now is taking over 90 mins to work.

Lubiprostone was a last resort- I am 7 days into 24mg twice a day and nothing except nausea sickness the worst bloating I have ever had to the point I can't breathe by the evening. My chest is tight and my arms are having muscle spasms. I am dispairing....."