Milnacipran
"I have suffered from Chronic Lyme Disease and Fibromyalgia for twenty years and have been on high-dose morphine, Neurontin, Lyrica, Cymbalta and others, all of which had very bad side-effects and awful withdrawal syndromes. Three weeks ago I started Savella, but titrated very slowly 12.5mg/day for two weeks and now 25 mg per day. There were some pretty bad days of side-effects in the first week and still some nausea and difficulty sleeping, but the benefits are much better than any other drug I've used for pain and fatigue. My pain was always at 9.5, and is now mostly around 4-6 (a vast improvement). Unlike all the other SSRIs I've tried, Savella gives me energy and new optimism!"