Methotrexate
"I live in the UK & have had plaque psoriasis for 20 yrs. After various lotions, UVB & PUVA, my knees & elbows became infected and I could hardly walk or sleep with the discomfort. As I also have depression, my dermatologist decided on prescribing methotrexate as my quality of life was so severely affected. I take 15mg tablets once a week, within a month it had all but gone, & has remained that way. It has been a year since I started, it's such a relief not to think about my knees all the time! I also take folic acid, & the skin on my face has become quite oily, but it's definitely worth it. I've recently noticed the few patches I have left are beginning to increase in size, but I hope this improves with the arrival of summer!"