Acetaminophen / butalbital / caffeine
"I was terrified when Midrin was discontinued.  This was the medicine that replaced it, and I hoped it did just as well as Midrin did at knocking down the headaches.  It did!  I am terribly sensitive to caffeine, but the amount in this didn't cause a reaction in me.  I didn't notice much of any side effects other than a little fluffy-headedness.  Normally my migraines last a few days, and in the course of a headache episode I could take 30 or more Tylenol.  I usually take one Esgic as soon as my headache starts and that's the end.  One pill and hardly any discomfort, compared to 30 or more Tylenol that barely mask the pain."