Meperidine
"I don't know if it's me or what but I was given Demerol (along with Vistaril and Vicodin) after my ankle surgery and it hasn't helped at all. I was admitted to the hospital twice where I received Dilaudid. That did the trick. I had a screw removed from my ankle, which had shattered and the doctor drilled through my fibula bone. After I was released, I was given Vicodin to be taken one hour after my Demerol and Vistaril. That seemed to work. I was surprised that the Demerol needed a "kick" so to speak. I would definitely ask my doctor for something more again if I ever had to go back on it."