Sertraline
"The Dr. prescribed this med after I developed a tolerance to Prozac after 15 wonderful years.  I started at 25 mg. They always say to give it a few weeks to see if it is working.  After 2 months he increased the dosage to 50 mg. which still did not work.  Then after an increase to 100 mg. for a few months, he finally believed it was not working for me.  He started me on Effexor, which took another 6 months of gradually increasing dosage to actually kick in.  Please do not give up.  After over a year of living a nightmare and feeling suicidal every single day, I'm now back to normal, almost every day."