Propofol
"I have had over a dozen MAJOR surgeries. Opium tolerant, I recently went for a shoulder replacement. When the anesthesiologist injected Propothol into my IV, I experienced - not some little burn - but some of the most INCREDIBLE PAIN of my life. It literally felt like someone had injected sulphuric acid into my veins and it was now making it's way through my veins. This lasted @10 seconds before I went under. I remember screaming and thought I would break the nurse's hand. Unfortunately, I have endured some pain many will never experience in their life... unfortunately, this rated among some of the worst."