Sodium hyaluronate
"60 year old women with bone on bone and need TKR, however my doctor suggested Euflexxa saying I was too young for surgery.  I am one and a half months out from my third injection.  After the first injection I was able to sleep through the night without my knees locking, which was a huge improvement. My doctor said to take it easy for 48 hours after each injection and to ice four times a day.  Right knee responded much better than the left, but I do have some pain relief in both knees.  I started Physical Therapy 4 weeks prior to the injections and the doctor advised to continue as long as my insurance will pay.  My doctor advised I will be at my optimum 3 months out from the third injection."