Linaclotide
"Like others have reported, worked first couple of days, then not so much. However, with some tweaking, for me, I now take it at least one hour (not 1/2 hour as directed) before I eat in the morning and works every time! Literally, before Linzess, would not have a BM without a laxative for 2 weeks. So, Linzess is a miracle drug for me!"