Clonidine
"I have night time spikes in my blood pressure and I also have Polycystic Kidney Disease which affects my blood pressure a lot because sometimes its too low, sometimes too high! I take lisinopril 40mg Norvasc 10mg and Cadurra 8mg for blood pressure maintaining but I have a script for clonidine 0.2mg twice a day as needed and what usually happens is I take first full dose at night when my blood pressure begins to rise then I wait an hour and check blood pressure and take .1 mg of clonidine and do same thing in another hour and what I've learned is that for me clonidine effects my heart rate within 30 minutes which is not good because I don't really have a high heart rate and clonidine has made me drop into the 40s a few times while trying to lower blood pressure."