Lubiprostone
"I have been taking this medicine 24mcg once a day for a week now. Nothing has happened yet. I drink 1 to 2 quarts of water a day, on the fodmap diet, eat tofu, fresh fruits and fresh vegetables. Also eat a lot of chicken. I have had no luck so far. I have left 3 messages with my doctors nurse and no call backs yet. I feel bloated, full of gas and feel miserable. So I am stuck taking laxatives, Epson salt enema's or citrate mag (awful tasting stuff ever) then feeling sick all the next day with upset tummy and sitting on the throne off and on all day. I clean myself out about every 3 to 4 days because I feel miserable and sluggish and it starts all over again after cleaning myself out. I have had this IBS-C for about 20yrs now. It ruins my life!"