Metformin
"I have been taking glucophage ER for 4 weeks.  The first couple of weeks it made me very sick.  I was told this was normal and to try to hold out and the side effects would stop.  They seemed to and then the dose was increased and I am sick again.  It works really well to get my sugar down.  Before I started  it was an average of 146 or 6.7 for A1C

Now the average is 101.  Since it is working I am going to hold on for a few more weeks.  I have been told that some people get used to it much faster than I have and some people take a few months."