Acetaminophen / butalbital / caffeine
"My doctor prescribed Fioricet as a first-line treatment for my headaches.  (I'm still not sure whether they're migraines, tension headaches or something else but they always happen during my period).  



Fioricet definitely works, albeit with some side effects.  I react poorly to sedative drugs like butalbital in that I get awful rebound anxiety/depression after only a couple doses.  All the more reason to use this medication sparingly.  There's a definite euphoric effect that lends itself to abuse.  The combo of caffeine + a sedative is a strange one, but it works when all OTC stuff has failed.  I much prefer it over something like Topamax."