Carbidopa / levodopa
"I've had RLS since a child. I began on Carbadopa in the 1990's, but I quickly became used to it, and was switched to Sinemet about 2000. It works well, with no side effects. I'm on a very low dose.

Like many others here, timing is everything and there are many other factors to consider:
- Take Sinemet at least 1/2 to 1 hour before you eat.
- Eat early (so food digests before you go to bed).
- Eat a light meal (heavy or spicy foods can amplify the symptoms of RLS).
- Refrain from drinking liquids about a hour before bed.
- Stress can aggravate RLS symptoms (try yoga or some other stress reduction activity).
- Adjust the room temperature to be comfortable.
- Maintain a healthy weight.
- Exercise!!!"