Tramadol
"I have severe RLS. I tried requip, mirapex, neurontin, lyrica... Like many others who have posted, I had a pinched nerve in my spine (upper back, near my neck) and was prescribed Tramadol. It greatly improved my RLS !! It truly was a God-send !! I do have to take 100mg three times a day. And, if I take it too late, I do have to wait for an hour or so for the symptoms to finally diminish. Also, I have some daytime sleepiness, sluggishness. And now that my pinched nerve has become inflamed again, I have severe RLS even while taking the Tramadol. I am hoping that after having a spinal injection for inflamation, my symptoms will improve once again. Until then, here I am, up with the rest of you, enduring this aggravating condition."