Tioconazole
"I have used monistat 1 several times. Sometimes I have no burning and other times (one time in particular) I have such severe burning that I cannot sleep through the night. I continue to use monistat 1 because it WORKS 100% of the time. The time that I had the worst pain, I had let the YI go on for a while with no treatment and was very inflamed by the time I used monistat. I thought this was why I had such an adverse reaction, but I have also treated an oncoming an infection immediately and I still had moderate burning (but not severe). I would still recommend this product to most people, but I recommend taking it just before going to bed and falling asleep before the full burning hits (about 2 hours after insertion)."