Estradiol
"At 46, I had a Total Abdominal hysterectomy 6 months ago due to adenomyosis and severe endometriosis. Had no hormone therapy at first  the doctor took a wait and see approach. One month ago I started having intense hot flashes and joint inflammation.  Doctor prescribed 1 mg estradiol a week ago and I noticed my symptoms vanished almost completely by day 2. I learned after trial in error that taking it in the morning works best for me as it gives me a ton of energy. I'm starting to feel human again."