Mirtazapine
"Remeron helped very much initially. After trying a host of other depression meds, this one seemed to work and had minimal side effects after the first week. However, at a low dose it stopped doing the job and have had to go up twice to the max dose of 45 mg. I no longer sleep well, and have had HUGE weight gain and ended up with diabetes. I plan to gradually wean myself off and treat the depression with natural means--exercise, diet, supplements."