Metformin
"I have been on metformin ( the regular one) 850mg once a day at night since May 2014 for Polycystic Ovarian Syndrome. The first day I took it I had the worst explosive diarrhea. I persisted with it and it was giving me bouts of nausea, stomach cramps, poor sleep and diarrhea. It has been 3 months now and the symptoms have stopped. I think if you persist at it, and definitely take it after a meal, it will be okay! My periods are still being artificially controlled with norethisterone daily so I can't comment if metformin has regulated my menses, but I am hoping to stop the norethisterone soon!"