Oxymorphone
"I have been on MS-Contin for 15 years.  In that time, only one dose increase!  I take 2x60 mg daily.  Every 2-3 months, my doc changes medicine.  I used to be able to get Opana, 40 mg 2x per day, and it worked great!  Even better was Efalgo, 16 mg 3 x per day.  2 in the morning, one at night.  Now, insurance will not pay for either.  The only medicine I can tolerate is Opana, 80 2x per day, and they really don't work well.  It is so frustrating that the medicine that is the hardest to tamper with, Efalgo, is the hardest to get and most expensive! If I don't switch every few months, I build up a tolerance. I suffer from degenerative disc disease in my lower back, arthritis etc."