Brimonidine
"I still have flare ups during the day but there are times where my skin is completely free from any redness, especially about an hour after it's applied.  It losses its effectiveness after about 6 hrs for me. After the tube is open I've tried to stretch it out past 30 days but it's effective is not as good when the tube is first opened I've found. I remember it taking a few weeks when I first started using it along with a topical cream at night for my skin to start to change.  My script ran out and I went without it for a week and I hated not having it. My skin burned and hurt again when I stopped using it for that time.  Although it doesn't completely eliminate systems it sure does help and I will not go a day without it."