Rituximab
"I have Undifferentiated Spondyloarthropathy, MCTD & SLE. I started Rituxan at the end of December 2015 after Enbrel lost efficacy. I am also on MTX & Plaquenil. My rheum explained that Rituxan works in a different manner from the TNF inhibitors and because of this it takes longer to work. While I began noticing Enbrel's efficacy within 2 weeks and was in remission by 3 months, with Rituxan I didn't even notice any difference until about 10 weeks in. I have slowly improved, but I am not in remission. Prior to Rituxan most of my joints were painful; after 14 weeks I am down to about 15. My daily pain level has gone from about an 8 to 4 or 5. My rheum said sometimes patients will see a better response after dose #4. I hope for remission. I will redose in 6 months following the RA guidelines."