Meloxicam
"I took this drug for about 5 days as directed, for low back arthritis -- I became despondant about my life -- and did not immediately connect this feeling to meloxicam.  When I got to thinking about it I checked the side effects, and the oddly specific and very accurate "discouragement" was a side effect.

I'm a tough kid, oilfield worker, long time rugby player etc -- and I'm not kidding when I tell you there was a three day period there where I honestly felt like I was an inch from crying -- and I probably would have been crying if I just wasn't so tired of life, and going nowhere etc (mind you, this was during the oil boom, so I was doing great).

I removed myself from the med, and started to be my old sunny self within a day or 2"