L-methylfolate
"So we are still learning about methylfolate and its effects in depression as it's still pretty new (megavitamin) and we're still learning about the role genetics play in the methylation cycle. I noticed a boost after a week on 15mg then it disappeared. I kept taking even though it wasn't really working anymore. Then after about six weeks I got a huge boost and as I was also on Wellbutrin at the time, it was actually way too much serotonin in my system. I think some people need doses much lower than the prescription strength and it can take a while for the full effect to kick in. It can take a little while to get back to a healthy level but it can definitely help boost whatever else you're on. Look out for hypomania if you're bipolar."