Naloxegol
"I have been on opioids for 20 years at least.  So constipation kind of rules my life. I too ended up in emergency twice, but all they did was give me an enema which never works for me. I saw a Movantik add on tv, so I asked my Dr. if I should try it. He agreed and wrote me a prescription. When I got home I took one, and it had no effect at all. Just nothing. So I decided to check the reviews on this drug and people have had just too many problems with pain , cramps, all sorts of awful things. Since it didn't work, I felt lucky. I don't want to go through the pain."