Xeljanz
"Been on Xeljanz XR 11 mg for about 10 days now. I've tried most of the infusion drugs and Methotrexate and none have worked.  It's a little early to tell for sure but I think it's helping. I don't have typical RA, no flares, I am in a constant flare. No coming and going unfortunately.  I also have whole body swelling, lucky me. But I am noticing a slight reduction in swelling.  I had gone up a full ring and shoe size. Today I could get on a ring I haven't been able to wear in years....yay! I have had some strange side effects. Extreme fatigue, depression,  skin crawling and a little paranoia. Not typical for me and I don't think for this drug either. I seem to always have the rare side effects with all medications. I'm hopeful though."