Cymbalta
"I had blissfully forgotten how much pain I had been living with before taking Cymbalta, until I ran out unexpectedly. Pretty short half-life. The pain was debilitating and constant; much worse were the very unpleasant withdrawal symptoms which took hold very quickly - won't list them as they probably were related to my brain trauma. Obviously it's best not to run out, but if so, be aware of the withdrawal symptoms and pain returning. The good news is that all that unpleasantness is gone relatively quickly: 2-3 days. 

Another point: not covered by my insurance, and I take 90mg/day ($$$), but my G.P. spoke to Lilley (manufacturer) who agreed to provide me with 6 months worth at a time - gratis! Worth checking into."