Opium
"I have a J-pouch.  For the past 30yrs +  since my surgery, I have been using either Tincture of Opium 10% or Morphine Sulfate to control my almost constant diarrhea.  To date nothing else has worked.  I am now taking a powder cholestyramine which does help but in order to actually stop my running to the bathroom all day, I still have to take the Opium.  It keeps me awake so I cannot take it at night.  I can honestly state I am not addicted to it.  I am now down from 10ml 2 times a day to 2.5mls 1 time per day.  If I can find something to replace it I will.  The cost even for the smaller quantity is still almost prohibitive for me to continue with it."