Scopolamine
"This medicine is a Godsend. I suffer from SEVERE motion sickness (cars, planes, boats, trains, etc...) Bonine/Dramamine don't work for me at all. I tried the Scop patch and I couldn't believe it, no motion sickness! I was able to make it being a passenger in the car going down the entire pacific coast highway without even feeling slight nausea. If you know what that road is like, you know how crazy that road is for someone with motion sickness. Side effects were light, slight dry mouth, slight dilated pupils, not much drowsiness. Only negative is the withdrawal I had after using 3 patches one after the other, but that was easily controlled with Dramamine. A    "