Indomethacin
"Was prescribed two 75mg SR (morning and evening) and felt very drowsy and tired every morning. Switched to 1x per day (evening) and get almost the same benefit and feel fine.  Other NSAID drugs did not reduce AS inflammation for me. In combination with Enbrel the indomethacin has controlled my AS for 12 years now. Minimal pain and I can run and exercise."