Tranylcypromine
"I've dealt with major depressive disorder for 22 years and have always had to be on several anti-depressants at one time. They only lessened my symptoms in the best of cases, but did nothing most of the time. I've been on every antidepressant in addition to things like risperdal as an adjunct. I was on 450mg welbutrin, 60mg remeron and 120mg cymbalta concurrently with no effect when I decided to take the MAOI plunge. That was 18 months ago. It's truly amazing to feel normal. I'd forgotten what that felt like.

I do have to say the first couple of months were the most brutal med adjustment I've ever been through. Very glad I hung in and didn't give up."