Desvenlafaxine
"I was originally on Prozac 20mg for my depression.  I found the Prozac helpful, but emotionally numbing.  I am participating in psychotherapy and it got to the point that I couldn't really access my feelings and it was interfering with my therapy. I spoke to my doctor and he switched me to Pristiq 50mg. I found that it was easy to adjust to (some nighttime sweating but that's about it).  It gives me very good control of my depression.  My irritability is also very well controlled.  However, I am now able to access my feelings when I need to (such as in therapy) and I feel less numb. I am still able to manage stress just as well as when I was on Prozac, yet I don't feel so disconnected from the world and from myself."