Ibuprofen
"I am 35 year old male with moderate to severe sciatica (pain from buttock to ankle) due to bulging disc L5 - S1.  I found taking a 400mg dose gave significant but not total relief for about 2 to 3 hours.  The effect was greater if the pain was not too severe, the best results came from taking ibuprofen before the pain got severe.  I also found that taking Ibuprofen without food made it work faster but I suffered moderate diarrhea as a consequence."