Nortriptyline
"I've was diagnosed with interstitial cystitis a little over a year ago. This chronic pain disease is a curse!! I tried so many different things to make the pain go away- natural methods (such as digestive enzymes, cranberry supplements, probiotics), the IC diet, the alkaline  diet, and switching to all alkaline water. Finally I couldn't take it anymore and my doctor told me to try 10mg of Nortriptyline. It started working the very next day. I would say I'm 90%better. I still have minor flares before I go to bed if I'm stressed. My doctor told me to increase slowly to 50mg but I haven't needed to go up from 10mg. I hope this works for the rest of my life because I can't go back to the way I was before this medicine. It honestly saved me."