Tramadol
"Was prescribed for knee injury. I tried all sorts of SSRI,  SDRI , tricyclics,  etc. for unexplained depression. All of them had side affects so detrimental that it made me more depressed. Of course the so called doctors want to give you more drugs to counter the side affects all the while claiming your a border line heroin addict all the while having no idea what is causing the depression all the while suggesting it's all just maligned thought processes.Thank goodness I have arthritic knees. After taking tramadol by depression is gone . Fact. Every patient is different. Don't be pigeon holed.  I have been taking one 50mg per day for years. Works somehow. If it is placebo then why didn't all the other Meds work the same. For once I'd like to hear a Doctor just say " i dont know."