Methotrexate
"I've been on methotrexate for 3 years at 8 tablets (2.5 mgs).  For some reason I only have psoriasis on my hands and then only my thumbs and the center of my inside right hand. That has cleared up considerably to where it is no problem. Thank goodness I have not got it anywhere else.  I noticed that my knees, which had been painful, stopped hurting entirely after about six months. Before it was quite painful... now I have no pain.  I haven't been taking the folic acid like I should."