Bupropion / naltrexone
"I started taking Contrave for menopausal weight gain. I srtated it 1 week before my fiance left me for a millionairess.  Not sure if it was depression or contrave (likely a combination), but I lost almost 30 pounds in a month.  Now it's been 6 months, and I'm down 34 pounds.  I was vomiting the first week, but that went away quickly.  Only other side effect is slight muscle twitching.  I was barely overweight, but no diet or exercise would take the excess weight off.  I'm thankful."