Otezla
"3 weeks in.  Abdominal issues definitely present.  Not diarrhea but cramping, nausea, bowel urgency.  Lasts around 2 hours after taking the medication.  Can sleep through the side effects from the evening dose now.  Not sure if having any emotional effects.  Skin is clearing well for just three weeks on the med.  I had been on Enbrel for around 3 years and alternated from the 25mg dose to the 50mg dose.  Essentially stopped working. Must have developed antibodies."