Tapentadol
"I have severe rheumatoid arthritis and pain is something I live with daily and I have tried many different pain killers such as Tramadol, Endone and Jurnista. I have been taking Tapentadol for almost 3 months now, starting on 100mg 2x daily and am currently taking 150mg 2x daily.  While it takes the edge off the pain it does not reduce it significantly and most nights after taking the evening tablet I manage to sleep for a few hours but wake in pain when the supposed sustained release tablet has worn off and can not get back to sleep due to high pain levels. I am heading to my GP today hoping for some relief as this really isn't doing the job."