Emsam
"I tried EVERYTHING to get over what was first diagnosed as depression (30 years ago).  About 12 years ago I started seeing a psychiatrist who thought I might be bipolar, type 2 (mostly depressive, no full-blown manic state) and started me on Emsam.  It took some time-can't really remember but maybe a month but it works.  Yes, there are side effects-insomnia being the worst but that dissipated in a few months.  We all know that what works for one person may not for another but this is not an SSRI which can't "touch" depression associated with bipolar.  And you don't have to be bipolar for it to work.  I know it's frustrating but give it a shot-maybe you'll be like me and never have to try another medicine again!"