Humira
"I take Humira for rheumatoid arthritis and so far it's the only medicine that works for me. I've tried Plaquenil and methotrexate but they don't even touch the pain/swelling.  I began to feel relief the morning after the first shot of Humira. Don't let the instructions scare you. The shot is not painful. I let it stand on the counter 15 minutes before I give it so it's not so cold. My Doctor suggested that I sit in a straight back chair so that the abdominal area is already pinched and you'll have both hands free, then pick a spot on my stomach that's 2 inches away from the navel and just do as the directions explain. You won't feel the needle, but the medication will burn just a little.  I can't even say it hurts. Don't be afraid."