Linaclotide
"I shared my experience in June/2016 when I started taking Linzess & it was great at first. Unfortunately, the diarrhea continued every day and my stomach got big & bloaty, headaches & acne!? I tried every second day, at night, with more water but as time went on the side effects got worse. I was going to the bathroom, but not completely, with all the water & gas remaining inside. I read posts about weight gain and watched myself carefully, everything I ate and worked out but suddenly noticed I was "puffy". I realized I was dehydrated from the Linzess and I stumbled across an acticle saying "dehydration slows down metabolism"! I also started feeling a little down, I got off & back to my old drug Resolor! Side effects gone & I feel better!"