Pristiq
"I have had severe depression  for about 1 year now. My psychiatrist and I have tried just about all SSRI's/anti-depressants (Prozac, Paxil, Effexor, Abilify, Deplin, Cymbalta). I started Pristiq ER about 4 months ago. WOW!I felt about 50% better in 3-4 weeks, than I had in several months. At my follow-up appointment I asked my Doctor to increase my dose and he did. I now take 100mg daily. Although my depression has plateaued, I'm not AS depressed as I WAS. Suicidal thoughts, and worthlessness are a lot less. I also have very few side effects. I've lost about 15lbs while on it. So if you are truly desperate I would recommend you try this one next."