Trintellix
"Male, mid 30s, depression for ~10 yrs. Was on Cymbalta 60 mg QD for 2yrs, wasn't working, depressed, so up'ed to 90 mg QD. Didn't work, had typical side effects. Cross tapered to Brintellix over 3wk period achieving 10 mg QD dose. Felt good for 2wks - more energy, sharper mentally, but very angry and irritable. Then all "good" effects ceased; all I felt was continual anger and irritation, which worsened every day for 3wks. Put on 12lbs/1mo while being on Brintellix. Stopped 10 mg dose cold turkey for 1wk, just started on Fetzima. Can't tell if Brintellix withdrawal or Fetzima, but now having sexual AEs, namely near spontaneous ejaculation without being erect or stimulated - any other men have this with either drug?"