Acetaminophen / butalbital / caffeine
"I've been taking Fioricet for 40 years.  I've had migraines for 53 years.  I was 19 when it was first prescribed for me, before that, my life revolved around my headaches.  Fioricet changed my life for the incredibly better.  I'm third generation migraine sufferer, so I suppose there's an argument for a genetic predisposition.   Up until I was 19, headaches were an almost daily occurrence since I was very young, lasting from 8 hours to days.  So many things triggered them that I won't even begin to make a list.  I am careful about the acetaminophen component, which seems to be the main potential negative health issue.  Rebound headaches can also occur, but, it's nothing compared to the life enhancing benefits, at least for me."