Vortioxetine
"I had been on generic Lexapro 10mg for about 18 months and it treated my depression well, but I gained almost 40 pounds, was a bit sleepy, and was experiencing sexual side effects.  I was scared to try something else but the weight gain was just too much, especially since it seemed to continue.  My doctor gave me Trintellix 10mg samples which I've taken for a month and what a difference!  I no longer feel sleepy all of the time and the difficulty in achieving orgasm is gone.  As for the weight issue, i'll have to see if it helps.  I feel much more "normal" than on Lexapro as far as energy and mental focus.  The only downside is I do feel more anxious and have more nervous energy, so I don't know how well this drug would treat anxiety."