St. john's wort
"During college, I did have a prescription for medication such as a few SSRIs epression and anxiety. I felt these drugs offered some relief from my depression; but they did little to nothing for my anxiety, and in fact I side effects that were unwanted (sexual, loss of interest in stuff, etc). I became interested in SJW after it was mentioned on a bodybuilding form as a supplement some people were taking. I read it helps with depression, and was generally regarded as safe, so I bought a bottle of the pills and took one. Within one hour, I immediately noticed a more 'calming' feeling. Considering it placebo, I ignored it. A week later, the effects are stable. Depression is gone, and anxiety is significantly lower."