Linaclotide
"I started on linzess in April 2015. I thought it was my miracle drug, but it seems to have stopped working as well, and I have severe bloating/ abdominal distention. To make matters worse, I've gained weight. Not water weight either. I work out and eat low carb, but since starting linzess the scale is going up. It's looks as though I'm not the only one. Linzess needs to list potential weight gain as a side effect. But why would they do that? It's all about sales."