Propranolol
"Like many others on this site I have a terrible fear of public presentations that was only getting worse with time and it was starting to severely hurt my job path.  The fight or flight adrenaline rush at the beginning of a presentation was crippling.  Got prescribed propranolol and it saved my career.  I'm still extremely nervous before public speaking with clammy hands and a rolling stomach but it absolutely stops that adrenaline blast and I can speak normally.  Keys for it to work for me are taking enough of it long enough before speaking.  Caffeine appears to limit its effectiveness in my experience.  I'm a 34 year old male and take 60 mg total - 20 mg 90 minutes before speaking and 40 mg an hour before.  Been on it 3 years, love it!"