Spironolactone
"I was given this medication by a dermatologist assistant, and started with the low dose of 50mg. I was a bit "dried out", had to urinate more and was drinking more water. I didn't see much difference in my acne until she increased the dosage to 100mg but then I saw a major improvement. The draw back is that I am 44 years old, and my periods were getting heavier, a longer duration, and started every other week. I had some depression spells where I would cry over something very minor. I feel this medication is great for the acne sufferer who has had the same stubborn big deep blemishes for a long time, but for a hormonal person such as myself pushing menopause, it isn't ideal unfortunately. "