Tramadol
"Have had restless legs syndrome for 7 years and MD tried multiple medicines (Requip, Neurontin, Carbidopa/Levodopa).  All worked OK but still had RLS in the day and night.  Then, I hurt my back and was put on Tramadol three times a day.  My RLS completely went away but I had problems peeing.  So, I went off and those symptoms went away (but the RLS came back).  So, now I take one pill a day and the RLS is gone and I have no side effects."