Linzess
"I have been on opioids for many years and that was increased in 2013 with a knee replacement surgery.  That's when the constipation became uncontrollable.  All the fiber in the world would not move me. Until linzess.  It is still unpredictable some days, ( unexpected and explosive) but it is better than being backed up, bloated and miserable.  I've been taking it on and off because my insurance would not pay or they would pay fora lower dose which I cannot use except very infrequently."