Spironolactone
"I was prescribed 50mg of Spiro a day with topical Tretinoin Gel (19 year old female here). I started noticing improvement in my acne after I introduced that topical gel into the equation (so I imagine that the topical caused most of the improvement). Two weeks after starting Spiro, I started noticing hair all over the sink and a ton in the shower drain. I experienced tightening of the throat on and off after a week (a subtle annoyance, not super severe) and didn't attribute it to the Spiro, but eventually I realized my voice sounded very deep, unacceptable as I'm a singer. I had no idea this was a side effect until I looked up Spiro side effects and it explained everything. I stopped taking it after this and won't go back at this dosage."