Isotretinoin
"I've had acne since I was 11. Nothing my doctor prescribed had any effect on my skin so I started my course of isotretinoin when I was 17. In short, it gets worse before it gets better. My skin only started improving in the last month of my course. I still have acne but it's not nearly as bad (and with my newly vamped up skincare routine it's getting better daily).
As with most acne treatments, it was pretty drying (you'll need a good moisturizer and lip balm) but it's nothing permanent. I didn't find the pregnancy/blood tests a hassle either, at this point I was willing to do anything to sort out my skin. I think it was totally worth it! If, like me, you've had acne for years and years, it's definitely worth a try!"