Spironolactone
"I have been on Spironolactone 50 mg a day now since August 2016. After being blessed with clear skin the majority of my adult years, I suddenly was stricken with deep, painful acne, all over my  checks, mouth and forehead. I originally tried doxy for three months with little to no success. Transitioning to Spiro was the best thing I ever did. Warning: It WILL get worse before it gets better!!! My skin was the worst it ever was the first two weeks starting it. But it slowly started clearing (noticable results within 2 months), and now after 6 months my skin is the best it's been in years! I take this in conjunction with clindamyacin (which I've been on for 10 years). Stick with it!!! It WILL get better!"