Metformin
"Many subtle side effects that clear over time.  Chance of infection side effect is curious as that is a condition to be religiously avoided with diabetes of any type.  Also since starting Metformin I have red skin on right leg that seems to never go away.  More than a coincidence I think that this appeared right after starting this medication.  I am finding controlling my diet and exercise a much better solution than current drugs but will take for a while longer."