Estradiol
"I was on this for 3.5 months as directed and it literally did not work at all at any dosage. I started with one spray, graduated to two after a few weeks, then three after about 8 weeks. It didn't seem to diminish my symptoms at all. I was having several hot flashes an hour and terrible insomnia. I switched to a patch 3 days ago and haven't had one hot flash and I've been sleeping more sound. Wish this could have worked for me. I'm not sure if it has to do with how thin my forearms are? No idea but it was like I used nothing at all."