Duloxetine
"I was prescribed Cymbalta for a combination of chronic pain from osteoarthritis and major depressive disorder with melancholia. I started with 30mg for the first two weeks, but had to stop taking my daily 1200 to 1800mg of ibuprofen and also quit drinking. For depression, it was amazing. I felt relief from my despondency within a handful of days, and that has continued through this, my third month. I had my dose increased to 60mg to try and get relief from the chronic pain, but it has not been effective for me in addressing that - thus my rating. For depression, I give it a 10, but for pain (my experience) I have to give it at best, a 3. After consulting with my doctor, he said I could resume taking ibuprofen at a much lower dose."