Desvenlafaxine
"Been off/on antidepressants for 20  years. Been on 100 mg of Zoloft for about 5 years now and was having some adverse effects- gained a lot of weight for starters.  Started Pristiq about 3 weeks ago. I feel a lot clearer in the mind- guess I didn't realize the Fog I was in on the Zoloft. I'm not hungry- lost seven pounds in the first two weeks. Had some headaches while switching over. Sleep hasn't been a problem- but I have found that I need to take the meds at the same time in the mornings or I have headaches. So far, so good. Hopefully it will continue long term. I will probably be on meds the rest of my life- I've come to terms with that. Hoping this will be the last one I'm on!"