Metoprolol
"I take metoprolol tartrate not metoprolol with hydrochlorthiazide, however I have noticed a marked frequency of urination and polyuria after starting this medication.  My doctor suspected a urinary tract infection (although I am not experiencing dysuria, fever, chills or having any other typical UTI symptoms).  Urinalysis was negative, prostate exam was negative, cystoscopy was negative.

The medicine is doing what it is supposed to be doing, but having to urinate every two hours around the clock is certainly interfering with my sleep.  I did find a reference on Drugs.com that said increased urination was a rarely encountered side effect of this drug, but my doctors insist it doesn't have that side effect and I have spent a fortune ruling out other conditions."