Spironolactone
"I started Spironolactone for Acne in April and started out taking 50mg a day and I will say for the first three months I thought it wasn't working (I was still getting a lot of cystic acne breakouts around my chin and mouth). But I figured I would give it some more time because my body may still be adjusting to the other medications I'm also using with it (derm also put me on orthotricyclen birth control to help with acne as well as Differin cream twice a week) I stuck it out and noticed a drastic change in the fourth month and I'm now on month 5 and have had no breakouts for a month straight! I also lost about 8 pounds since I started on the medicine! Which was a great bonus. I recommend sticking it out!! It takes time but it really works!"