Metformin
"Diagnosed as "pre-diabetic", A1C 5.9. GP said my triglycerides high and prescribed metformin 500 mg twice a day.

1 pill a day had no obvious side effects. Adding pill #2 gave diarrhea if taken at the same time. So I shifted pill #2 to lunch and it gave diarrhea after 2 days in a row.

So I worked my way up to 2 a day. Mon & Thur for month. Mon/Wed/Fri for a month.  Etc.

My A1C is now 5.3-5.7, with my insurance the generic is super cheap  (less than $1/month), and if I have diarrhea for any reason I skip the 2nd daily pill.

Metformin is working fine for me."