Naloxegol
"I have full body RSD. (CRPS). I started taking opiates for the first time, 10mg of Methadone 2x's a day since Oct of 2015. Linzess high dose never really worked. I tried Movantik and it worked the first day. After that, horrific abdominal pain and cramping. Almost couldn't drive when it hit me when I went to Vote here in Florida. This drug is garbage. Expensive garbage. Try it, but be careful. Don't get your hopes up."