Niacin
"I had severe depression on and off past few years. This time round it was unbearable and I was literally falling apart mentally. Sadness and torment, that would not go away, anxiety and lack of sleep for over a year etc. I refused taking synthethic meds and decided to give niacin a go.
it worked pretty much instantly. I started on about 300mg (severe flush like sunburn and itchy skin), then calmness. I was upping the dosage almost each time, and flushes eased eventually.
 Now (2 weeks later) I take 1500mg 2-3 times a day and the flush is slight with warm face and chest. 
Sadness is gone and I feel much more "with it". It seems to be blocking unwanted thoughts. hands down- a true depression cure."