Dexamethasone
"I have mixed connective tissue disease, with rheumatoid symptoms.  I have severe back pain due to degenerative arthritis of the spine.  About every three months I get an 80 mg Depo Medrol IM injection.  Works wonders to knock out the inflammation.  I went to my doctor to get an injection - I was in severe pain - the nurse gave me Dexamethasone 10 mg IM instead.  My first reaction was acute euphoria - my daughter said I acted like I was drunk - and this lasted about 10 minutes.  Then I had something I can only describe as confusion, and the pain came back and it was worse than ever.  I felt terrible for days.  I reported this to my doctor and the NP, who were very cavalier and said that it should have worked the same. "