L-methylfolate
"I have suffered with some depression but mostly anxiety for the past 15 years. I have taken Celexa and then Lexapro off and on (mainly on) for most of those years. While the Lexapro helps some, I still always had difficulty with my energy levels and with coping during really stressful situations. I was recently tested for MTHFR gene mutation, and was found to have the 1298c mutation, which can affect my brain's ability to utilize folate in order to make needed serotonin, dopamine, and norepinephrine. My doctor prescribed Deplin (l-methylfolate), and even though I had read many good reviews, I was still hesitant. I have to say it has been a miracle for me. It's like this dark cloud has been lifted, and my anxiety has completely disappeared."