Morphine
"I have suffered for many years with AS and Degenerative Disc disease. With all the NSAIDs, Methotrexate, and pain killers I developed ulcers in my esophagus, stomach and duodenum. Thankfully my Doctor decided to switch me to Morphine because it is easier on the system. Now I take 60 mg MS Contin twice a day and 4 to 6mg Dilaudid as needed for breakthrough pain. The plus is that the ulcers have all healed and although the pain is not totally gone it is very manageable. The minus is that I have had to gradually increase my dosage over the years because your body learns to tolerate it. Adjusting to a new dose can take a little while and it causes constipation (Benifiber works great)."