Mirtazapine
"I've had major depression mostly everyday for the last 2 years and this medication is a lifesaver.  After being on mostly every SSRI and on several different dosages I never got complete relief from them. They helped to give me a slightly better mood on most days but the depression was always there. After doing a lot of research I told my psych I wanted to try mirtazapine.  After roughly two and a half weeks on 30 mg (15mg didn't help) I've never felt better.  It also took away most of the night sweats that I was getting from SSRIs. I've read some people complaining about weight gain as a side effect, I would advise to not worry about weight gain if you actually have major depression, once the depression lifts you will be able to eat healthy."