Isotretinoin
"I was on a 16 week course with 30mg/day the first month & then 50mg/day the remainder of the time. At first it got a lot better, then it got a lot worse - which is to be expected. It took so long as to the 14th week to really see a big change and now I've just finished the full 16 weeks and my skin is better than ever. There are still some spots that need to be healed but other than that I'm amazed. 
My doctor explained to me that the medication keeps working in your body for 8 weeks after you've stopped taking the pills & when you're on them some people's skin is so sensitive it's like glass & therefore for some people the pills really work its wonders after you've stopped them. So DON'T give up. Also, Aquaphor is lifesaver for dry lips."