Quetiapine
"Well had many changes or should I say increases in medication as I seem to only get 12 months benefit then medication becomes less and less effective. Regarding  quetiapine I was on 60mg a day. 9 months ago I started to become ill again. I became suicidal. so saw my psychiatrist. He  said the current thinking was 600 to 800 mg of quetiapine.  was the effective dose to take for bipolar. So now I am on 600mg every evening. I am back to being well and have been for many months  The only side is effect is relaxing of muscles, talking like a drunk.So to take it early evening,and go to bed  once I start feeling drowsy,"