Spironolactone
"I began having acne at age 20. Went to a ton of doctors was put on doxy for 6 months, lots of topicals, and accutane, and none of it worked. Five years later it turns out my testosterone levels were way too high and I have Polycystic ovarian syndrome. Gyno put me on 200mg a day. First month I was very nauseous and dizzy. I wanted to sleep all the time. It's been two months and the side effects are gone, but I'm still breaking out. Hopefully it works after a couple more months. I suggest any adult acne sufferer try this out before you spend years trying things that are not effective. My acne scars are awful and I need dermabrasion now."