Metoclopramide
"I'm an ER nurse. We use a cocktail of 20 mg metoclopramide with 25 mg diphenhydramine. That's 2 vials of reglan and 1/2 vial of benadryl in a 250ml NS bag.
Reglan is the primary medication in this cocktail, benadryl is given to reduce the side effect known as akathisia. Both reglan and benadryl causes drowsiness, hence only half a dose is given. 250ml saline bags are used so we can control the rate of flow of the medication (to infuse slow over 20 minutes, we don't use an IV pump with these medications). Ketorolac is optional.
If not given correctly, in most cases infused as a bolus/wide open. This is where the problem occurs.
I would say It has a success rate of 80%.
I've seen akathesia just twice, I give it cautiously every time."