Vortioxetine
"I have had 7 major depressions over the past 12 years. Each one lasted about 5 months and I have previously treated this with Effexor but the doses escalated to 525mg so needed to try something new. Started on 10mg Brintellix about 5 weeks ago. Nausea went after 4 days and mood improved after 2 weeks. Unfortunately my mood started to deteriorate again at about week 4 so I increased the dose to 20mg. Had to go through the whole nausea/tiredness again for 4 days. After a week on this dose things have again improved so I'm hopeful that this will continue. This is the first time something has worked so quickly and effectively for me. Hang in there with the side effects - it's worth it."