Dihydroergotamine
"If you suffer from an anxiety disorder or depression, I would be very cautious with this medication. I suffer from chronic migraines and anxiety and depression, and was given DHE on multiple occasions for my acute migraines. As soon as the medication entered my body, I felt restless and anxious. Within 2 minutes, I was having a full-on panic attack; I was completely terrified even though I knew I was entirely safe. The horror consumed me & I lost my perspective and was convinced that I would feel that way for the rest of my life. I felt so hopeless that I couldn't bring myself to ask the doctor for help. It did help with the acute head pain, but it left me so terrified and anxious that I was back in the ER within 2 days for another migraine"