Spironolactone
"I would say I had a good experience with Aldactone.  My skin did clear, although I do remember having a little bit of a break-out now and then.  I started taking the medicine about 6 months before my wedding (I was age 29 then) and I stopped a couple months after the wedding.  My skin looked very good and the breakouts diminished. I don't think I experienced any bad cystic type acne then.  I used the highest dosage of Retin A (just a tiny bit) at night also along with a Cetaphil moisturizer.  Since I was getting married, I was very cautious about weight gain and I don't think I gained weight from the medication, although I was going to the gym regularly and doing weight regimens. I think I'm going on it again. I will also go on Epiduo."