Bupropion
"I have been on over 15 different antidepressants across every category. I have taken monoamine oxidase inhibitors (Ensam), tricyclic antidepressants, SSRIs (several - Effexor, Pristiq, etc.) and nothing worked. I'm taking Welbutrin 150 mg once a day (along with the Effexor XR still at 300mg) and it is incredible. I feel amazing. Unfortunately, after 3 weeks I developed hives all over my body that were itchy. While the itchiness went away after 3 days and the hives only come out at night now, my blood work shows I'm having a bad reaction to it. I also lost 14 lbs in 4 weeks (a good thing). I do feel extremely anxious and agitated at times and can't stop wiggling my foot, for example. Combined with the Effexor (which causes too much sleep), my sleep is at the right length now."