Spironolactone
"I am a 43-year-old healthy female. No diabetes, no high cholesterol  and not on any other medications. I had to start taking spiro because of edema. My legs and feet were were so puffy I could barely wear shoes.  I've been on spiro for a week now.  I lost 6 pounds of water in the first three days of taking it. My legs and feet are still puffy so progress is gradual.  I also elevate my legs whenever I can.  I've never used another diuretic other than this one so I can't compare it.   My doctor prescribed it for two weeks only, I take it in the morning with my breakfast and have not experienced any side effects at all except mild thirst in the mornings upon waking up."