Spironolactone
"I started taking this medication about four months ago combined with minocycline for my hormonal cystic acne. The first month I saw no improvement in my skin and abnormally lost 5 pounds. Now three months later my skin is finally completely clear but I'm facing a new problem: the medicine has caused me to gain 10 pounds in my thighs, butt, tummy, and breasts and has given me a yeast infection that has been on and off (mainly on) for the last four months."