Roflumilast
"Have been on Dalisrep over 2 weeks now; could tell much improvement in my breathing. Didn't need to use supplemental oxygen at all. However, yesterday, I couldn't take the nausea, vomiting, tremors, leg aches, headaches, bathroom trips, any longer.  I tried taking the meds with and without food, didn't seem to make any difference.  I'm wondering how long the side effects last?  It seems some people don't have side effects at all.  I am so disappointed that I won't be able to continue this drug as I feel that it was helping me with my breathing.  But I can't stand the side effects any longer.  I have lost 10 lbs in the 2 weeks, I have no appetite whatsoever, and I know that I need the nutrition as prednisone causes bone loss."