Desvenlafaxine
"I've been taking 50 mg Pristiq in combination with 300 mg Wellbutrin for two weeks, and it's the best I've tried.  This week I've been able to handle family and work issues with a sense of hope and able to focus rather than anxiety/ worrying, and that's awesome.  I had been taking Prozac and Wellbutrin for years but felt it wasn't working.  I tried everything but other meds didn't work or had bad side effects.  This made me queasy at first, but my dr. had said that would get better, and it did.  I take it at night because in the morning, it makes me tired.  So don't give up!  There is hope.  Hang in there. "