Pristiq
"I've been taking Pristiq for 2 full months now.  It helps me get up and out of the house and I don't feel as hopeless.  People aren't getting on my nerves as much either. Continuing side effects for me are sleepiness, headaches and a rise in blood pressure.  I'm seeing my doctor to taper off as the side effects are too much.

In the first few weeks I noticed a dramatic loss of appetite which has unfortunately gone away.  I have some weight to lose.  For a while there I was eating like a "normal" person, which was really nice.

I've been on everything, most recently Prozac and Cymbalta.  Just don't know if there's anything left to try."