Desvenlafaxine
"I was on low dose Cymbalta for 2 weeks and could not handle the fatigue. I switched to Pristiq 50 mg a little over a week ago. My anxiety is 95% gone, my depression..the negative thoughts are gone, I'm not happy but I'm not sad either, my irritability and being easily startled has resolved. I'm able to go out without being anxious, am  returning to work part time in a few weeks. I do feel a little tired a few hours after taking the medication but it doesn't last, my sleep is a little disrupted, little nausea but nothing I can't manage, constipation is a side effect but I use Colace (without the laxative), lost 4 lbs so far. Plan to stay on this indefinitely at this point. Just relieved to finally have some relief from the anxiety/depression."