Tramadol
"I have lower back pain due to spondylosisthesis. (Disk between LV4 and LV5 moving forward and putting pressure on nerves in spinal column)
Tramadol works ike a narcotic, it can cause extreme nausea if never used before.  Unfortunately,  a tolerance develops very fast; at first, 100mg would kill my  back pain completely.  But over two years time, i need about 300 to 400 mg twice a day,  with an NSAID booster. The injections my doctor gives me in my knees and spine are very effective in restoring lost flexibility,  but still Tramadol cocktail for pain. I'm 66 years old and also have tendonitis in my knees and SI syndrome. Pregabalin is great with tramadol"