Vortioxetine
"Took my first 10 mg Brintellix just before I went to bed at around 11:00 p.m.  It's now 6:30 a.m. & I haven't slept.  Not a wink.  Going forward, I will definitely be taking them in the mornings.  I just arbitrarily rated it as a "5" since I've only taken one.  Other than being wired, I haven't had any negative side effects.  I never hold out much hope for any new antidepressant, though.  It seems that nothing works for me.  I will take Brintellix for at least a couple of months before deciding if it works & whether or not I want to continue taking it.  The cost will also factor into this (in a big way).  My dr. gave me a month's worth of samples & a card for some sort savings program..."