Linaclotide
"I'm a 45 yr old woman who has had IBS with chronic constipation for years. I've been dependent on laxatives for years mainly suppositories. Even strong laxatives have little effect on me. I hate taking meds and often just do not take care of my gut. Well that's all changing since I wound up at the ER last weekend with a terrible back up. 

I saw my GI Dr and he gave me some samples of linzess 290 mcg. I'm taking that every morning along with a probiotic, a stool softener and high fiber diet.  

It's only been 3 days but so far I've felt activity down there and had a BM yesterday morning and today. I still needed a suppository but I hope by this and probiotic and diet change i can be more regular."