Isotretinoin
"Had moderate acne for 10 years and tried just about everything: BP, topical/oral antibiotics, retinoids, spirono, birth control, etc. and my skin was very oily to top it off, making my acne practically undefeatable. Last year I developed horrible cystic acne on my chin and my derm urged me towards accutane. Well I can tell you it's caused the worst breakout ever on my cheeks: painful, blistering nodules connected deep under my skin. I got prescribed prednisone and azithromycin for that, but it didn't help. I have to take benzaclin now and my face has never been this dry, painful, and red. I'm going into my 4th month with horrible skin and things are looking bleak. The only good thing that's happened so far is that my blackheads are gone."