Linaclotide
"I've had stomach issues for most of my life (I'm 41) and have tried "everything," with no reliable consistency. I've tried the OTC medicines, Miralax worked for some time then stopped. Suppositories once a week had become my only source of bowel motions. I took Amitiza for 6 weeks, with no positive results.
I took 2 doses of Linzess and Boy! I spent the next 6  hours in the bathroom. Not fun. I even had to step out, mid-shower, conditioner in my hair, to use the bathroom more! And cramps, oh the cramps. This is my 2nd week with the samples my Dr. gave me. I took a pill yesterday...and the same cramps and episode occurred. Didn't last as long but hurt as much. I am sore this morning; my stomach hurts. I will continue with Linzess, it works."