Lubiprostone
"I have been on this for about a week. First few days, was amazed. Before this medicine I would do enemas every week or so due to pain, etc. The day after I took this medicine, I went three times, once after every meal. Wow! Same for the next few days. Side effects: Majorly tired, headaches that develop into migraine by end of day, weird feeling in chest and throat, breathing funny (like a bad cold) and VERY nauseated until I have a movement. Also, the last few days, only having movement every other day. So don't know what is going on. Need to try increasing the water and see how that goes. Don't know if normal bowel movements are worth all this, plus, it seems to not work as well as it did a few days ago."