Naloxegol
"I have been on different opiods for a chronic pain issue for 15yrs but, since I started taking methadone 5 years ago I've had horrible problems with constipation. They kept me on myralax 34mg twice a day  and stool softners but even that would only allow me to use the bathroom maybe 3x's a week. I was given relastor as the injection at home and the pain was unbearable for 9 hours and, it did not work. I was so scared to take Movantik but, I'm so glad that I did! Just one pill and everything inside me finally came out! My cramping is very minimal, nothing that really hurts much at all, more "Hey, the pill is working" type of movement and cramps. They have coupons for $20!"