Adapalene
"I was very sceptical about using differin cream as I had done a lot of reading and has obviously read about the dreaded initial breakout! A side note, I am also on lymecycline 408mg (tetracycline is the same) and I'm on lucette bc. When I first started using it I left it on for an hour, to see how my skin reacted, then washed it off. I have been leaving it on overnight now for about a week and a half. Yes, I have broken out. Any worse than usual? No. In fact the breakouts healed, were less aggressive and red. Currently the only side effect I've got is the corners of my mouth are a bit sore and dry. My skin is very soft where I use the cream. My advice, start slow! And use it so sparingly!! Literally the tiniest bit. I am pleased so far. :)"