Vortioxetine
"One week at 5mg, three weeks at 10mg. No intolerable side effects, and it has by far been the most rapidly-acting antidepressant I've tried (I've been on four others). Unfortunately, this is because I cycled into hypomania by the second week on 10mg. Too bad! I didn't want to come off this drug, but it wasn't safe to continue. But hey, it worked - I don't even HAVE depression anymore, because whoops, I'm bipolar!"