Spironolactone
"I've struggled with moderate acne since the age of 11 or 12, and I'm now 26. I've tried benzoyl peroxide solutions, salicylic acid, tretinoin cream, doxycycline oral antibiotic on numerous occasions, clindamycin cream, and the list goes on and on. Nothing ever worked, and I learned to live with acne - I learned how to cover it to the best of my abilities and to try to act like it didn't bother me. But honestly at any given point I had at least 8-10 pimples. By the time I turned 24, I had started with horrific large pimples on my chin and cheeks, and I pleaded with my dermatologist to start me on something different because I had just had enough. Spironolactone was the best thing to ever happen to my skin!!! I started at 50mg daily, then after 2 weeks it was increased to 100mg daily. I noticed within 4-6 weeks that my skin was clearing up and I no longer was getting new breakouts.  I've been on it now for 10 months, and honestly I don't think I've even had one pimple in the past 2 or 3 months. This stuff is simply amazing. If you struggle with acne, I would recommend at least trying this. I never thought I would ever have clear skin, and I now have completely clear smooth skin. It's incredible. The only side effect I've had is fatigue, so I do take it at night before bedtime, and I wake up very well-rested. In addition, I pee a lot more often as is to be expected from a diuretic, so I drink tons of water to make up for it. Also as a side note, I've lost about 10 pounds since starting it which is also a plus :)."