Tapentadol
"I've been taken Nucynta 100 mgs twice a day and 50mgs of the IR three times a day. Before that I was taking Percocet 10/325 4/day and OxyContin 20mgs just at night. The first day of taking Nucynta, I had a headache, probably from the norprenephrine. However, today it has been nothing but great. I have a bad back which it helps tremendously (as did the Percocet) but I also have severe neuropathy in my calf and right foot. For those, Percocet didn't help too much. As far as pain relief goes, it has been excellent. In fact, for the first time in literally 5 years, I only had to take 2 of the instant release instead of 3 that I'm prescribed. It definitely is a unique opioid though. I think it's great though!"