Vortioxetine
"I am a 64 year old female.  I have been on antidepressants since I was 13.  I have been diagnosed with PTSD, Bi-polar and major depressive disorder.  I felt most normal while taking Prozac, however, during the past ten years, I lost both parents, made a major move, and my husband was diagnosed with Alzheimer's.  The Prozac just didn't seem to be working.  My physician switched me to Wellbutrin,  and then to Cymbalta...the Cymbalta and my stomach didn't hit it off, so she put me on Brintellix.  I am very pleased with this medication.  I do have nausea, so I try to eat something before I take it.  I seem to be hot all of the time, some itching, and I have had a significant weight gain! Which is not listed as a side effect."