Eluxadoline
"For the last 20 years I have had issues with IBS-D. I'd say I would have a "normal" bowel movement 5% of the time with about 1-2 occurrences of rushing to the bathroom per day and the rest of the time just unpleasant bowel movements. My Gastro prescribed 75mg Viberzi and it worked almost immediately. I'd say in the first week I had two occurrences of diarrhea and the rest of the time I was "normal".  After a month I have had diarrhea a total of 3 times, and had some of my best bowel movements in the last 20 years. I've even eaten Taco Bell several times and not had to go. It is truly freeing to not feel nervous about whether I would make it home in time after eating dinner."