  ==Neuronal Targets of Cocaine== ===Dopamine===  Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement (2007) J. Dalley  Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys. (2007)  D2-Autoreceptors Chronically Enhance Dopamine Neuron Pacemaker Activity J Neurosci 2006 May 10; 26(19): 5240–5247.  Cooperative activation of D1- and D2-like DA receptors in the NAc shell is required for cocaine-seeking behavior in the rat (06) H.D. Schmidt  Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction (2006)  Changes in extracellular dopamine during cocaine self-administration in squirrel monkeys. Synapse, 56:129-134, 2005.  Dopamine and drug addiction: the nucleus accumbens shell connection. Gaetano Di Chiara, Valentina Bassareoa, Sandro Fenua, Maria Antonietta De Lucaa, Liliana Spinaa, Cristina Cadonia, Elio Acquasa, Ezio Carbonia, Valentina Valentinia and Daniele Leccaa 2004.    ===N-Epinephrine=== Difference in magnitude of psychostimulant-induced extracellular norepinephrine in the ventral tegmental area contributes to discrepant prefrontal dopamine outflow Pan WH, Hsieh MC, Wu HH, Lin SK. Addict Biol. 2007 Mar;12(1):51-8.  Alpha-Noradrenergic Receptors Modulate the Development and Expression of Cocaine Sensitization (2006).  Role of the increased noradrenergic neurotransmission in drug self-administration. Wee S, Wang Z, He R, Zhou J, Kozikowski AP, Woolverton WL. 2005  Neurochemical interaction between dopaminergic and noradrenergic neurons in the medial prefrontal cortex Wynn Pan, Sze-Yuan Yang, Shi-Kwang Lin  Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Gainetdinov 2000  Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys (95 Spealman)  ===Serotonin=== Effects of Combined Dopamine and Serotonin Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys. (2007)  Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration ('05)  Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs (2005)  Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. PNAS, January 6, 2004; 101(1): 372-377.  Serotonin1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels 04   Serotonergic Attenuation of the Reinforcing and Neurochemical Effects of Cocaine in Squirrel Monkeys. JPET 2002 300: 831-837.  The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant. Ronald B.P. Jobe 2005  ===σ–Receptors=== σ Receptors: potential medications development target for anti-cocaine agents (03) Matsumoto  Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides R. Matsumoto, K. McCracken (2002).  ===Cholinergic=== Pharmacological Characterization of Nicotine's Interaction with Cocaine and Cocaine Analogs J Pharmacol Exp Ther 1999 289: 1229-1236.  [http://dx.doi.org/10.1007/s002130050198 Ritz* Cocaine toxic