  == Can more detail be added to dosage, overdose,? == The dosages of aspirin for Pain, Fever 0.3 to 1 gram repeated up to a maximum of 4 grams per day Acute Rheumatism  4 to 8 grams per day divided doses. Chronis Rheumatism 300 to 900 mg every 4 hours. Ie a maximum of 5.4 grams per day. Also Overdose The Lethal dose for an adult is thought to be 25 to 30 grams but treated overdoses of 60 - 90 grams have recovered. Fawns & McAllen Pty Ltd The maximum recommended dose of 8 grams is a little under 1/3 of a fatal dose. Combined with the pharmokinetics in the article - When small doses (less than 250 mg in an adult) are ingested, all pathways proceed by first-order kinetics, with an elimination half-life of about 2 to 4.5 hours.[112][113] When higher doses of salicylate are ingested (more than 4 g), the half-life becomes much longer (15–30 hours)  is there a risk of chronic poisioning at 8 grams per day if the half life is 30 hours.?? Central Effects? Salicism: Mild salicylate intoxication Nausea, vomiting, tinnitus, hyperventilation, occasionally diarrhoea. These are not symptoms of hypersensitivity, but indications that the toxic dose is being approached.Aspro Clear Nicholas Australia.  