`:Addressing & understanding ``Natural vitamin E`` is definitional.  ``Natural vitamin E``, the natural alcohols, includes the mixed tocopherols where pure alpha tocopherol supplements are rare, and excludes the common ``natural source`` d-alpha tocopheryl esters.A Papas, The Vitamin E Factor, HarperPerennial  :LPI is a voice at the lower edge of the OMM dose ranges, even lower than Pauling, trying to bridge the shortest distances with the mainstream, so LPI should not be counted as addressing the entire OMM range here.  Save that for Hoffer, Pauling, J Orthomed, and OMM practitioners.  :Many editors and consumers are confused on ``natural`` about vitamin E.  Normal ``mainstream`` advertising practices in the past typically called ``natural`` what is now labeled ``natural source`` (usually d-alpha-tocopheryl acetate or succinate).   This is in fact is not ``natural``, but semi-synthetic, the ``natural source`` raw material being esterfied and then methylated to convert all other RRR-isomers into d-alpha-tocopheryl esters.A Papas, The Vitamin E Factor, HarperPerennial  Literal ``natural vitamin E``, as a practical matter is a mixture that ranges d-alpha + 25% w/w other RRR isomers, the legal minimum ``mixed tocopherols``,  to d-alpha + ca 200+% w/w other RRR'' isomers, for supplements with high potency concentrates like UniquE (1962).  :Hoffer: ``There are eight vitamin E isomers in nature...[use the natural form]...orthomolecular physicians have been using dosages of 400 [iu] and upward following the [Shute brothers]...VItamin E is the last of...antisenility vitamins we will discuss....  The best dose ranges from 800 - 1600 [iu] per day.`` :Pauling''', often on OMM's lower dose edges, in ``How To Live Longer...``, Ch 18, 27, discusses vitamin E, the natural tocopherols and treatments up to 3200 iu.  Pauling mentioned counting rough tocopherol equivalents, (e.g. d-gamma tocopherol as 1/10 IU per wt as a same weight of d-alpha-tocopherol is the modern ``TE``, tocopherol equivalent).  Others just use the alpha fraction IU recommendation as a part, independent of beta-, gamma-, delta-tocopherol quantity.    `