   ::Hello David, nice to talk to you again. Regarding your question, I have four things to say.  ::* One: Gilbert syndrome is indeed a very common and benign condition. I'm not a specialist in that specific disease category, but based on my studies as well as on Gilbert patients I've met, I would agree more with your second GP, in that the symptoms you described are unlikely to be caused by Gilbert syndrome. Indeed, the concept of the latter being utterly asymptomatic except for mild jaundice is what is supported by renowned medical textbooks (I went back and did some additional reading since you asked), and I would definitely give more credit to them than to websites, even the well-meaning ones. Which brings me to the next point.  ::* Two: Please do not trust the web for health-related information. I can perfectly see why a concerned person would turn to websites - if you're concerned, you want more information, and that websites offer easily, as opposed to actual medical literature (difficult to access, and written for people with medical training). Still, the medical information on most websites is unreliable, and you should especially distrust websites that do not declare who the author is (and if he/she holds any medical qualification). Take the one you mentioned, for example. Not only it is anonymous, but also notice that the section about Gilbert symptoms is based on complaints reported on a web forum. That has got to be unreliable, for example because: there's no guarantee that those people actually had Gilbert syndrome and/or that they did not have some other condition accounting for those same symptoms (and since they are quite vague symptoms, there's a host of possible causes). The discussion on the talk page for Gilbert's syndrome you linked above has a good explanation about why sources like that websites should be disregarded. Now, of course there are reliable health-related websites out there: those that belong to scientific societies (for example, http://www.escardio.org is a reliable source of heart-related information because it belongs to the European Society of Cardiology).  ::* Three: I suppose it is true that there has not been much innovation in the way of research about Gilbert syndrome after its basic genetic / enzymatic mechanism was discovered. The only point that remains obscure is why some people with the mutation never get the high bilirubin that should go with it.  ::* Four: I understand you are left wondering what is causing your symptoms then. Regrettably, this is not the kind of medical problem where adequate advice can be offered over the internet - without a full history, physical examination, and review of previous test results, I'd be just throwing guesses around in Doctor House style. I do think however that you and your current GP should definitely investigate your symptoms a bit further, perhaps undergo polysomnography and/or EEG if you haven't already, which would clear the field of some possible hypotheses, if nothing else.   