2-Decarboxy-2-aminomethyl-19-hydroxy-19-methyl-6-oxo-PGF1 compounds
CROSS REFERENCE TO RELATED APPLICATION 
     The present invention is a divisional application of U.S. Ser. No. 054,720, filed July 5, 1979, now U.S. Pat. No. 4,225,507. 
    
    
     BACKGROUND OF THE INVENTION 
     The present invention provides novel prostacyclin analogs. Particularly, the present invention relates to prostacyclin analogs substituted at the C-19 position by hydroxy. 
     Particularly, the present invention relates to 2-decarboxy-2-aminomethyl-19-hydroxy-19-methyl-6-oxo-PGF 1  compounds. The novel prostacyclin analogs are useful for pharmacological purposes, e.g., as anti-asthmatic agents. The preparation and use of these compounds is incorporated here by reference from U.S. Pat No. 4,225,507. 
     PRIOR ART 
     For background on prostacyclin, see for example R. A. Johnson, et al., Prostaglandins 12, 915-928 (1976) and R. A. Johnson, et al., J. Am. Chem. Soc. 100, 7690-7704 (1978), and, as to pharmacological activity, the references cited therein. For analogs of prostacyclin, see, for example, J. Fried, et al., Proc. Natl. Acad. Sci. U.S.A. 74, 2199-2203, K. C. Nicolaou, et al., J.C.S. Chem. Comm. 1977, 331-332, N. A. Nelson, J. Am. Chem. Soc. 99, 7362-7363 (1977), and K. Kojima, et al., Tetra. Letters, 1978, (1977), and K. Kojima, et al., Tetra. Letters, 1978, 3743-3746. Regarding the nomenclature for analogs of PGI 2 , see R. A. Johson, et al., Prostaglandins 15, 737-740 (1978). 
    
    
     SUMMARY OF THE INVENTION 
     The present invention particularly provides a prostacyclin compound of the formula ##STR1## wherein D is --(CH 2 ) 2  --CO--CH 2  L 2  -- or --CH 2  --CO--CH 2  --L 3  -- 
     wherein L 2  is 
     (1) --(CH 2 ) j , wherein j is one to 4, inclusive, 
     (2) --(CH 2 ) q  --CF 2  --, wherein q is one, 2, or 3, or 
     (3) --CH═CH--, 
     wherein L 3  is 
     (1) --(CH 2 ) n  --, wherein n is one to 5, inclusive, 
     (2) --(CH 2 ) p  --CF 2  --, wherein p is 2, 3, or 4, or 
     (3) --CH 2  --CH═CH--; 
     wherein Q is oxo, α--H:β--H, α--OH:β--R 4 , or α--R 4  :β--OH, 
     wherein R 4  is hydrogen or alkyl of one to 4 carbon atoms, inclusive, 
     wherein R 2  is hydrogen, hydroxyl, or hydroxymethyl; 
     wherein R 5  and R 6  are hydrogen, alkyl of one to 4 carbon atoms, inclusive, or fluoro, being the same or different, with the proviso that one of R 5  and R 6  is fluoro only when the other is hydrogen or fluoro; 
     wherein R 7  and R 8  are hydrogen, alkyl of one to 12 carbon atoms, inclusive, benzyl, or phenyl, being the same or different; 
     wherein X is 
     (1) trans--CH═CH--, 
     (2) cis--CH═CH--, 
     (3) --C.tbd.C--, or 
     (4) --CH 2  CH 2  --.