2-Decarboxy-2-aminomethyl-19-hydroxy-19-methyl-PG compounds
CROSS REFERENCE TO RELATED APPLICATIONS 
     The present application is a division of Ser. No. 025,878, filed Apr. 2, 1979 now abandoned. 
    
    
     BACKGROUND OF THE INVENTION 
     The present invention relates to novel prostaglandin analogs. Particularly, these compounds are analogs of the prostaglandins wherein the C-19 position is substituted by hydroxy, i.e., 19-hydroxy-19-methyl-PG compounds. Most particularly, the present invention relates to novel 2-decarboxy-2-aminomethyl-19-hydroxy-19-methyl-PG compounds, a disclosure of the preparation and use of which is incorporated here by reference from U.S. Pat. No. 4,228,104, filed Apr. 2, 1979. 
     PRIOR ART 
     Prostaglandin analogs exhibiting hydroxylation in the 19-position are known in the art. See, for example, U.S. Pat. No. 4,127,612, Sih, J.C., Prostaglandins 13:831 (1977) and U.S. Pat. Nos. 3,657,316, 3,878,046, and 3,922,297. See also the additional references cited in U.S. Ser. No. 025,878. 
     SUMMARY OF THE INVENTION 
     The present invention particularly provides a compound of the formula ##STR1## 
     wherein D is 
     (1) cis--CH═CH--CH 2  --(CH 2 ) g  --CH 2  --, 
     (2) cis--CH═CH--CH 2  --(CH 2 ) g  --CF 2  --, 
     (3) cis--CH 2  --CH═CH--CH 2  --CH 2  --, 
     (4) trans--(CH 2 ) 3  --CH═CH--, 
     (5) --(CH 2 ) 3  --(CH 2 ) g  --CH 2  --, 
     (6) --(CH 2 ) 3  --CH 2  --CF 2  --, 
     (7) --(CH 2 ) 3  --O--CH 2  --, 
     (8) --(CH 2 ) 2  --O--(CH 2 ) 2 , 
     (9) --CH 2  --O--(CH 2 ) 3  --, 
     (10) --(m-Ph)--(CH 2 ) 2  --, or 
     (11) --(m-Ph)--O--CH 2  --, 
     wherein --(m--Ph)-- is inter-meta-phenylelne, and 
     wherein g is zero, one, two , or three; 
     wherein Q is α-OH:β-R 5  or α-R 5  :β-OH, wherein R 5  is hydrogen or methyl; 
     wherein R 7  and R 8  are hydrogen, alkyl of one to 12 carbon atoms, inclusive, benzyl, or phenyl, being the same or different; 
     wherein R 2  is hydrogen, hydroxyl, or hydroxymethyl; 
     wherein R 3  and R 4  are hydrogen, methyl, or fluoro, being the same or different, with the proviso that one of R 3  and R 4  is fluoro only when the other is hydrogen or fluoro; 
     wherein W is oxo, methylene, α-OH:β-H, or α-H:β-OH; and 
     wherein X is cis- or trans--CH═CH--, --C.tbd.C--, or --CH 2  CH 2  --. 
     With regard to the divalent the substituents described above (e.g., Q) these divalent radicals are defined as αR i  :β-R j , wherein R i  represents the substituent of the divalent moiety in the alpha configuration with respect to the ring and R j  represents the substituent of the divalent moiety in the beta configuration with respect to the plane of the ring. Accordingly, when Q is defined as a-OH:β-R 5 , the hydroxy of the Q moiety is in the alpha configuration, i.e., as in the natural prostaglandin, and the R 5  substituent is in the beta configuration. 
     Specific embodiments of the present invention include: 
     2-Decarboxy-2-aminomethyl-19-hydroxy-19-methyl-PGF 2  α, 
     2-Decarboxy-2-aminomethyl-11-deoxy-19-hydroxy-19-methyl-PGF 2  α, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-19-hydroxy-19-methyl-PGF 2  α, 
     2-Decarboxy-2-aminomethyl-19-hydroxy-19-methyl-PGF 2  β, 
     2-Decarboxy-2-aminomethyl-11-deoxy-19-hydroxy-19-methyl-PGF 2  β, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-19-hydroxy-19-methyl-PGF 2  β, 
     2-Decarboxy-2-aminomethyl-19-hydroxy-19-methyl-PGE 2 , 
     2-Decarboxy-2-aminomethyl-11-deoxy-19-hydroxy-19-methyl-PGE 2 , 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-19-hydroxy-19-methyl-PGE 2 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-19-hydroxy-19-methyl-PGE.sub.2, 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-11-deoxy-19-hydroxy-19-methyl-PGE 2 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-19-hydroxy-19-methyl-PGE 2 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-15(S)-15-methyl-PGF 1  α, 
     2-Decarboxy-2-amninomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-PGF.sub.1 α, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-16,16-difluoro-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-PGF.sub.1 α, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-15(S)-15-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-11-deoxy-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-11-deoxy-16,16-difluoro-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-PGF.sub.1 α, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-15(S)-15-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetrahydro-19-hydroxy-19-methyl-11-deoxy-11α-hydroxymethyl-15(S)-15methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-11-deoxy-11α-hydroxymethyl-16,16-difluoro-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-15(S)-15-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-PGF.sub.1 β, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetrahydro-19-hydroxy-19-methyl-16,16-difluoro-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-PGF.sub.1 β, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-15(S)-15-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetrahydro-19-hydroxy-19-methyl-11-deoxy-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-11-deoxy-16,16-difluoro-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-15(S)-15-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetrahydro-19-hydroxy-19-methyl-11-deoxy-11α-hydroxymethyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetrahydro-19-hydroxy-19-methyl-11-deoxy-11α-hydroxymethyl-16,16-difluoro-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetrahydro-19-hydroxy-19-methyl-PGE.sub.1, 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-PGE.sub.1, 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-11-deoxy-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-11-deoxy-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetrahydro-19-hydroxy-19-methyl-11-deoxy-11α-hydroxymethyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-11-deoxy-11α-hydroxymethyl-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetrahydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetradehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-4,5,13,14-tetrahydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-16,16-difluoro-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-15(S)-15-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-PGF.sub.1 α, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-16,16-difluoro-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-15(S)-15-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-16,16-difluoro-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-15(S)-15-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-16,16-difluoro-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-15(S)-15-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-PGF.sub.1 β, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-16,16-difluoro-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-15(S)-15-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-16,16-difluoro-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-15(S)-15-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-PGE.sub.1, 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-11-deoxy-11.alpha.-hydroxymethyl-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-16,16-difluoro-PGE 1 , 
     2-Decarboxy-2-aminomethyl-2,3-didehydro-19-hydroxy-19-methyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-15(S)-15-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-16,16-dimethyl-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-16,16-difluoro-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-13,14-dihydro-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-11-deoxy-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-11-deoxy-16,16-dimethyl-19-hydroxy-19-methyl-PGF.sub.1 α, 
     2-Decarboxy-2-aminomethyl-11-deoxy-16,16-difluoro-19-hydroxy-19-methyl-PGF.sub.1 α, 
     2-Decarboxy-2-aminomethyl-11-deoxy-13,14-dihydro-19-hydroxy-19-methyl-PGF.sub.1 α, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-16,16-dimethyl-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-16,16-difluoro-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-13,14-dihydro-19-hydroxy-19-methyl-PGF 1  α, 
     2-Decarboxy-2-aminomethyl-19(R)-19-hydroxy-19-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-16,16-dimethyl-19-hydroxy-19-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-16,16-difluoro-19-hydroxy-19-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-13,14-dihydro-19-hydroxy-19-methyl-PGF 2  β, 
     2-Decarboxy-2-aminomethyl-11-deoxy-19-hydroxy-19-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-11-deoxy-16,16-dimethyl-19-hydroxy-19-methyl-PGF.sub.1 β, 
     2-Decarboxy-2-aminomethyl-11-deoxy-16,16-difluoro-19-hydroxy-19-methyl-PGF.sub.1 β, 
     2-Decarboxy-2-aminomethyl-11-deoxy-13,14-dihydro-19-hydroxy-19-methyl-PGF.sub.1 β, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-19-hydroxy-19-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-16,16-dimethyl-19-hydroxy-19-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-16,16-difluoro-19-hydroxy-19-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-13,14-dihydro-19-hydroxy-19-methyl-PGF 1  β, 
     2-Decarboxy-2-aminomethyl-19(R)-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-16,16-dimethyl-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-16,16-difluoro-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-13,14-dihydro-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-11-deoxy-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-11-deoxy-16,16-dimethyl-19-hydroxy-19-methyl-PGE.sub.1, 
     2-Decarboxy-2-aminomethyl-11-deoxy-16,16-difluoro-19-hydroxy-19-methyl-PGE.sub.1, 
     2-Decarboxy-2-aminomethyl-11-deoxy-13,14-dihydro-19-hydroxy-19-methyl-PGE.sub.1, 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-16,16-dimethyl-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-16,16-difluoro-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-11-deoxy-11α-hydroxymethyl-13,14-dihydro-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-19-hydroxy-19-methyl-PGE.sub.1, 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-16,16-dimethyl-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-16,16-difluoro-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-13,14-dihydro-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-11-deoxy-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-11-deoxy-16,16-dimethyl-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-11-deoxy-16,16-difluoro-19-hydroxy-19-methyl-PGE 1 , 2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-11-deoxy-13,14-dihydro-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-16,16-dimethyl-19-hydroxy-19-methyl-PGE 1 , 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-16,16-difluoro-19-hydroxy-19-methyl-PGE 1 , and 
     2-Decarboxy-2-aminomethyl-9-deoxo-9-methylene-11-deoxy-11α-hydroxymethyl-13,14-dihydro-19-hydroxy-19-methyl-PGE 1 . 
     The compounds of the present invention are particularly useful for inducing prostaglandin-like biological effects, as is described in U.S. Ser. No. 025,878. Uses of compounds in accordance with the present invention include, therefore, anti-asthmatic indications.