Method and apparatus for measuring the temperature of a glass container
BACKGROUND OF THE INVENTION 
     This invention relates to a method and apparatus for determining the sterilization of a container. More particularly, this invention relates to a method and apparatus for determining the temperature of the inside surface of an ampul as a function of time as the ampul is placed inside a direct flame sterilizer. Presently, there is no accurate means of measuring the temperature inside a glass container, such as an ampul, when the container is placed in a sterilizer. This is particularly true when the temperature is desired to be known as a function of time or location in the ampul. One of the techniques which is known in the art is to utilize a thermal melting paint or tablets which are sensitive to heat. However, this technique not only requires visual observation at the point of melt but does not allow for a permanent time versus temperature measurement to be made on a continuous basis. In the sterilization of glass containers such as ampuls, it is essential that the temperature of the inside glass surface be known to assure that sterilization of the ampul is accomplished. Otherwise, the container can possibly contaminate any otherwise sterile product which is placed in the container. 
     It is an advantage of the present invention to afford a method and apparatus for accurately determining the temperature of the inside surface of a glass container. Other advantages are a method and apparatus which can determine the temperature of the inside surface of an ampul as both a function of time or location in the ampul; an apparatus which will give a continuous temperature reading of an ampul as it is passed through a direct flame sterilizer; an apparatus which utilizes readily available equipment and can be placed in contact with a glass ampul without the need of special equipment; a method for determining sterilization of an ampul which can be performed without the need of skilled labor and by means of readily available equipment. 
     SUMMARY OF THE INVENTION 
     The foregoing advantages are accomplished and the shortcomings of the prior art are overcome by the present method for measuring the surface temperature of a glass container such as an ampul for sterile liquids wherein the junction of bare and substantially thin thermocouple lead wires are directly secured to the inside surface of the ampul. The bare lead wires are maintained separate from each other and are connected at the opposing ends to a thermocouple amplifier. The ampul with the lead wires attached is then placed in a sterilizer which will give a reading of the surface temperature of the ampul as a function of time that the ampul is in the sterilizer. The lead wires are utilized in a bare and uninsulated condition and are of a substantially thin type. The junction of the lead wires is placed in direct contact with the ampul surface and secured thereto by means of a high-temperature-resistive adhesive. The opposing ends of the lead wire are connected to a thermocouple amplifier which in turn is interconnected to a recorder means. Preferably, a connector will interconnect the thermocouple lead wires to the lead wires of the thermocouple amplifier. As indicated in the previously described method, the measuring apparatus best suited for accomplishing the method is a bare or uninsulated thin wire thermocoupled unit wherein the wire size is preferably 0.003-0.005 inches in diameter. Preferably a Chromel-Alumel lead wire thermocouple is utilized. The adhesive which is utilized to place the thermocouple junction in direct contact with the glass is of a porcelain type, being high-temperature-resistive and preferably containing silicates. In a preferred manner, the lead wires are separated from each other at the opening of the ampul by an additional amount of high-temperature-resistive cement material. The lead wires are then connected to a thermocouple amplifier by means of a two-component, separable, independent, thermocouple connector and a recorder is operatively connected to the amplifier. 
    
    
     DESCRIPTION OF THE DRAWING 
     A better understanding of the present surface temperature measuring device and temperature measuring method will be accomplished by reference to the drawing wherein: 
     FIG. 1 is a view in side elevation showing a thermocouple sensing device secured to an ampul and interconnected to a thermocouple amplifier and a recorder. 
     FIG. 2 is a partial, enlarged view of FIG. 1 showing the connection of the electrode wires to the ampul. 
    
    
     DESCRIPTION OF ONE EMBODIMENT 
     Proceeding to a detailed description of the present invention, the measuring apparatus 10 is utilized in conjunction with the usual ampul 11 for hermetically containing sterile liquids and solutions for I.V. administration. The ampul has a base portion 16 with a bottom 18, a neck 22 forming a continuous inside surface and funnel or open end portion 24. A thermocouple 12 having two thermocouple lead wires 13 and 14 are preferably of a Chromel-Alumel alloy type and have a diameter of 0.005 inch. The leads are joined at 15 and secured to ampul 11 at one end. The opposing ends extend from the ampul and are secured in a male thermocouple connector 25 which in turn is engaged with a separable female connector 26. Insulated thermocouple lead wires 29 and 30 extend from connector 26 to a thermocouple amplifier 23 which is of the standard type and in this instance is a Brush model 13-4312-10 amplifier available from Gould, Inc., subsidiary of General Electric, 2379 John Glenn Drive, Chamblee, Ga. 30341. If desired, a recording means 27 is interconnected with the thermocouple amplifier. Recording means 27 is also of a commercially available type under the designation Gould-Brush 260 Recorder model 15-6367-00 from Gould, Inc. at the previously indicated address. 
     As best seen in FIG. 2, thermocouple leads 13 and 14 are joined in a junction 15 which is secured in direct contact with the inside surface 17 of ampul 11 by means of a portion of adhesive cement 19. In this instance, the cement is of the high-temperature-resistive type containing sodium silicate to form a porcelain-like cement. It is available from Omega Engineering, Inc., Box 4047, Stamford, Conn. 06907. The preferred thermocouple 12 is available from the same source as a K-type thermocouple No. CH AL-005. The connectors 25 and 26 are also available from Omega Engineering as number NMP-CHAL-MF. Insulated thermocouple lead wires 29 and 30 are also obtainable from the same source as lead wire number AHC-K-20. 
     Referring to FIG. 2, it will be noted that the junction 15 of lead wires 13 and 14 is placed directly in contact with the inside surface 17 of ampul 11. In effect, the junction is encapsulated over the inside glass surface 17 through the use of the adhesive cement 19. This glass to metal contact is critical if a proper temperature determination is to be made. Also of critical importance is the fact that the lead wires 13 and 14 are of a substantially thin diameter so as not to produce a large heat sink effect and adversely affect the temperature reading. Another important feature is the fact that lead wires 13 and 14 are uninsulated so that their sensitivity is not affected. It will be seen that the uninsulated wires 13 and 14 are separated by means of adhesive cement 20 and 21 at the opening or mouth 24 of the ampul. While the lead wires are shown separated from the glass surface 17 of the ampul, it is not important that they be so and can be in contact with it. 
     OPERATION 
     A better understanding of the advantages of the temperature measuring apparatus 10 will be had by description of its operation. The lead wires 13 and 14 of the thermocouple 12 will have their junction 15 placed at a selected point on and in contact with the inside glass surface 17 of ampul 11. The contact with the lead wires and ampul 11 will be as basically shown in FIG. 2 with the lead wires interconnected to the amplifier 23 through connectors 25 and 26 as best shown in FIG. 1. For purposes of recording the information, recording means 27 will be interconnected with the amplifier. The measuring unit 10 is now ready to be placed in a sterilizer such as a direct flame ampul sterilizer of the type manufactured by Hodes Lange/Corning as Sterilizer Model APM-123 and available from Corning Glass Works, Corning, N.Y. 14830. Ampul 11 will be positioned in a holding mechanism of the sterilizer with the wires 13 and 14 extending through an opening in the top of the hood. As the ampul travels through the sterilizer, the temperature of the ampul will be known at all times during its time of travel and is of great importance in knowing at what stage an appropriate sterilizing temperature is reached. A typical time and temperature range sequence in the sterilizing unit would be as follows: 
     
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Temperature           Time                                                
______________________________________                                    
             350° F.                                               
                          56-106 - 106 seconds                            
             450° F.                                               
                          10- 69 seconds                                  
             500° F.                                               
                          17- 49 seconds                                  
Peak -- 444°                                                       
             -710° F.                                              
Hood Temp. 580°                                                    
             -790° F.                                              
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     The ampuls previous to entering the direct flame sterilizer are rinsed, ultrasonically washed and evacuated. Subsequent to the sterilization, the ampuls are processed in the usual manner with them being filled, flame sealed and then passed through a finishing process. 
     As indicated earlier, it is essential for accurate temperature readings that the junction 15 of the thermocouple be in direct contact with the glass surface of the ampul and that the lead wires 13 and 14 be of a substantially thin type and uninsulated so that no undue heat sink is created. Further, it is important that the length of leads 13 and 14 not exceed about two feet. 
     In the description of one embodiment of this invention lead wires 13 and 14 are stated as being of the Chromel-Alumel variety with the Chromel being an alloy composed of 90% nickel and 10% chromium by weight and the Alumel composed of approximately 95% nickel, 2% manganese and 2% aluminum by weight. Other metallic alloys could be utilized such as Chromel-Constantan or Copper-Constantan. Further, while the diameter of the lead wires is specified as being 0.005 inch, the diameter size could range from 0.001 inch to 0.010 inch. Measuring apparatus 10 is shown in FIG. 1 as being connected to amplifier 23 and recorder 27. For convenience purposes, it may be desirable to provide apparatus 10 to include ampul 11 with the attached leads and only the connector 25. The user can then provide connector 26 and the remaining stated amplifier and recorder. It will also be obvious that the measuring junction 15 can be secured directly to either the inside or outside surface of ampul 11. 
     It will thus be seen that through the present invention there is now provided a method and apparatus which can determine the temperature of the inside of a glass container such as an ampul at various time stages during the sterilization process. The method and apparatus is accurate in its measurement yet employs readily available equipment. No special skills are required for operating the apparatus and the unit can be fabricated with a minimum amount of effort. 
     The foregoing inveniton can now be practiced by those skilled in the art. Such skilled persons will know that the invention is not necessarily restricted to the particular embodiments presented herein. The scope of the invention is to be defined by the terms of the following claims as given meaning by the preceding description.