Antiatherosclerotic 7-substituted methoxyfurochromones
DESCRIPTION 
     CROSS REFERENCE TO RELATED APPLICATIONS 
     This application is a divisional of copending application Ser. No. 116,322, filed Jan. 28, 1980, now U.S. Pat. No. 4,284,569, issued Aug. 18, 1981, which is a continuation-in-part of application Ser. No. 11,816, filed Feb. 13, 1979, now abandoned. 
    
    
     BACKGROUND OF THE INVENTION 
     The present invention relates to novel furochromones which are khellin analogs and useful as antiatherosclerotic agents. Khellin is 7-methyl-4,9-dimethoxyfurochromone. Most particularly the present invention relates to 7-substituted methoxyfurochromones, the pharmaceutical use and preparation of which is incorporated by reference here from U.S. Pat. No. 4,284,569. 
     PRIOR ART 
     Extensive pharmacological uses for khellin and related substances are known. Khellin analogs are also known in the art. These analogs include: 
     (i) 6-chloromethyl- and 6-iodomethylfurochromones, see Abu-Shady, H., UAR J. Pharm. Sci. 11:283 (1970); 
     (ii) 6,7-dihalo-6,7-dihydrofurochromones, see Fabbrini, L., Ann. Chim. (Rome) 46:130 (1956); 
     (iii) 7-ethyl-, 7-propyl-, and 7-ethoxycarbonyl-4,9-dimethoxyfurochromones, see Schonberg, A., et al., JACS 72; 1611 (1950); 
     (iv) 7- -pyridyl analogs of 4,9-dimethoxyfurochromone, see Schonberg, A., et al., JACS 77:5439 (1955); 
     (v) 7-furanyl- and 7-isoxazolyl analogs of 4,9-dimethoxyfurochromone, see Musante, C., et al., Pharmaco (Pavie) Ed. Sci. 15:81 (1960); 
     (vi) 7-carboxaldehyde analogs of 4,9-dimethoxyfurochromone, see Mustafa, A. et al., J. Org. Chem. 26:886 (1961); and 
     (vii) alkyl and alkoxy analogs described in U.S. Pat. Nos. 3,099,660; 2,680,119 and 2,666,766. 
     Other furochromones are described in U.S. Pat. Nos. 3,483,194; 2,855,406; and 2,736,727. 4-Methoxy-7-(substituted)aminomethylfurochromones are also known in the art. See Abu-Shady, H., et al., J. Pharm. Belg. 33:397 (1978). 
    
    
     SUMMARY OF THE INVENTION 
     The present invention particularly provides a furochromone of formula VII ##STR1## wherein R 13  is: 
     (a) trifluoromethyl; 
     (b) phenoxymethyl; 
     (c) phenylthiomethyl; 
     (d) phenoxymethyl or phenylthiomethyl substituted by chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, or alkoxy of one to 3 carbon atoms; or 
     (e) cycloalkyl of 3 to 10 carbon atoms, inclusive; and 
     wherein one of R 3  and R 4  is methoxy and the other is methoxy or hydrogen. 
     These compounds are useful as anthiathersclerotic agents as described in U.S. Pat. No. 4,284,569. 
     DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     The present invention particularly relates to: 
     4,9-dimethoxy-7-phenylthiomethylfurochromone, and 
     4,9-dimethoxy-7-trifluoromethylfurochromone.