Hair revitalizing tonic composition
CROSS REFERENCE TO RELATED APPLICATION 
     This application is a continuation-in-part of application Ser. No. 392622 filed on May 24, 1989, now abandoned, based upon an international application PCT/JP88/00739 filed on Jul. 22, 1988. 
    
    
     BACKGROUND OF THE INVENTION 
     1. Field of the Invention 
     The present invention relates to a hair revitalizing tonic composition having an excellent hair loss preventive effect and hair revitalizing effect. 
     2. Description of the Related Art 
     In the prior art, the causes of hair loss from the head are considered to be (1) an activation of male hormones at organs such as hair roots, and of the sebum gland, (2) an insufficient circulation of blood to hair follicles (3) an abnormal and excessive secretion of sebum, and the formation of peroxides, among others. 
     Accordingly, compounds having the action of removing or alleviating the above-mentioned causes are usually formulated in the hair revitalizing tonic compositions of the prior art. 
     For example, vitamins such as vitamin E, vasodilators such as Swertia japonica extract, antiinflammatory agents such as hinokitiol, female hormone agents such as estradiol, and skin function promotors such as cepharanthine are formulated for a prophylaxis and therapy of alopecia. 
     Nevertheless, the mechanism of hair loss and hair generation is complicated, and a satisfactory hair loss prevention and hair revitalizing effect can be obtained only by inhibiting the activation of male hormones or increasing the circulation of blood to hair follicles, according to the hair revitalizing tonic compositions of the prior art. 
     SUMMARY OF THE INVENTION 
     Accordingly, an object of the present invention is to solve the above problems of the prior art and provide a hair revitalizing tonic composition having an excellent hair loss prevention effect and hair revitalization effect. 
     Another object of the present invention is to provide a hair revitalizing tonic composition having a greater hair loss prevention effect and hair revitalizing effect, and preventing dandruff or an itchy scalp. 
     Other objects and advantages of the present invention will be apparent from the following description. 
     In accordance with the present invention, there is provided a hair revitalizing tonic composition having an amine oxide formulated therein. 
     In accordance with the present invention, there is also provided a hair revitalizing tonic composition having an amine oxide and an anionic surfactant formulated therein. 
     The present invention is now described in detail. 
     The amine oxide usable in the hair revitalizing tonic composition of the present invention may include the following compounds: 
     (1) an amine oxide such as dimethylalkylamine oxide or dimethylalkenylamine oxide represented by the following formula (A): ##STR1## wherein R represents a straight or branched, saturated or unsaturated hydrocarbon group having 8 to 36 carbon atoms, preferably an alkyl group or an alkenyl group having 8 to 36 carbon atoms, preferably 12 to 28 carbon atoms; 
     (2) an amine oxide such as methyldialkylamine oxide or methyl-dialkenylamine oxide represented by the following formula (B): ##STR2## wherein R 1  and R 2  each represent a straight or branched, saturated or unsaturated hydrocarbon group having 6 to 36 carbon atoms, preferably an alkyl or alkenyl group having 6 to 36 carbon atoms, preferably 12 to 28 carbon atoms; 
     (3) an amine oxide such as dihydroxyethylalkylamine oxdie or dihydroxyethylalkenylamine oxide represented by the following formula (C): ##STR3## wherein R represents a straight or branched, saturated or unsaturated hydrocarbon group having 8 to 36 carbon atoms, preferably an alkyl or alkenyl group having 8 to 36 carbon atoms, preferably 12 to 28 carbon atoms; 
     (4) an amine oxide such an dimethylalkylpolyoxyethyleneamine oxide or dimethylalkenylpolyoxyethyleneamine oxide represented by the following formula (D): ##STR4## wherein R represents a straight or branched, saturated or unsaturated hydrocarbon group having 8 to 36 carbon atoms, preferably an alkyl group or an alkenyl group having 8 to 36 carbon atoms, preferably 12 to 28 carbon atoms, and n is an integer of 1 to 5. 
     In the present invention, these amine oxides can be used alone or in any mixture thereof. 
     In the present invention, the amount of the above amine oxide formulated may be from 0.0001 to 20% by weight of the total amount of the hair revitalizing tonic composition of the present invention. When the amounted formulated is less than 0.0001% by weight, a satisfactory revitalizing effect cannot be obtained, and an amount in excess of 20% by weight is not preferable from the aspect of preparation and/or skin irritation. The hair revitalizing tonic composition according to the present invention is not intended to be used for washing as the foaming during application can be a harmful factor, and therefore, a more preferable amount is 0.05 to 5% by weight. 
     This anionic surfactant usable in the hair revitalizing tonic composition according to the second embodiment of the present invention may include, for example, base materials for soaps; fatty acid soaps such as sodium laurate and sodium palmitate; higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate; alkyl ether sulfate salts such as triethanolamine polyoxyethylene (hereinafter abbreviated as POE) lauryl sulfate and POE sodium lauryl sulfate; higher fatty acid amide sulfonates such as N-myristoyl-N-methyltaurin sodium, coconut oil fatty acid methyltaurid sodium, and laurylmethyl-tauride sodium; phosphate esters such as sodium POE oleylether phosphate and POE stearyl ether phosphate; sulfosuccinates such as sodium di-2-ethylhexylsulfosuccinate, sodium monolauryol monoethanolamide polyoxyethylene sulfosuccinate, and sodium lauryl polypropylene glycol suflosuccinate; alkylbenzenesulfonates such as sodium linear dodeceylbenzene sulfonate and triethanolamine linear dodecylbezenesulfonate; N-acylglutamates such as monosodium N-lauroylglutamate, disodium N-stearoylglutamate, and monosodium N-myristoryl-L-glutamate; higher fatty acid ester sulfonates such as sodium hardened coconut oil fatty acid glycerine ester sulfate; sulfate oils such as Turkey red oil; POE alkyl ether carboxylic acids; POE alkylallyl ether carboxylates; α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfates; higher fatty acid alkylolamide sulfate salts; sodium lauroyl monoethanolamide succinate; ditriethanolamine N-palmitoylasparate; casein sodium; and the like, and these anionic surfactants can be used alone or as any desired mixture of two or more thereof. 
     The formulation ratio of the amine oxide to the anionic surfactant in the hair revitalizing tonic composition according to the present invention is not particularly limited, but is preferably 20:1 to 1:5, more preferably 8:1 to 1:2, in terms of weight ratio. When the formulation ratio of the amine oxide to the anionic surfactant is outside the above-mentioned range, a satisfactory dandruff and itchy scalp prevention cannot be obtained. Preferably, the amine oxide content is 0.0001 to 20% by weight based upon the weight of the composition. 
     According to the present invention, an amine oxide or both an amine oxide and an anionic surfactant can be formulated in a conventional formulation of a hair cosmetics composition to prepare a desired hair revitalizing tonic composition. As such a formulation, for example, there may be included water, an alcohol (e.g., ethanol, isopropanol, preferably ethanol, hereinafter the same), a water-alcohol mixture (e.g., 20 to 99% by weight of an alcohol, the balance being water), an oil component, a water-oil component mixture (0.2 to 80% by weight of oil component, the balance being water), an alcohol-oil component mixture (0.2 to 80% of an oil component, the balance being alcohol), an water-alcohol-oil mixture (20 to 99% by weight of alcohol, 0.01 to 80% by weight of an oil component, the balance being water), a water-oil component-surfactant mixture (0.2 to 80% by weight of an oil component, 0.01 to 10% by weight of a surfactant, the balance being water), and a water-alcohol-oil component-surfactant mixture (20 to 99% by weight of an alcohol, 0.2 to 80% by weight of an oil component, 0.01 to 10% by weight of surfactant, the balance being water). As the above oil component and the surfactant, any of those generally used in hair revitalizing tonic or cosmetic compositions of the prior art can be used. Examples of such oil components are olive oil, squalane, fluid paraffin, isopropyl myristate, higher fatty acids and higher alcohols. Examples of such surfactants are nonionic surfactants, anionic surfactants, amphoteric surfactants, cationic surfactants, and semi-polar surfactants. 
     In the hair revitalizing tonic composition according to the present invention, in addition to the above essential components, general purpose components ordinarily used in hair revitalizing tonic compositions can be formulated, within a range which does not impair the effect of the present invention, including vitamins such as vitamin B 6 , vitamin E and derivatives thereof, and biotin; hair generating agents or hair generating aids such as panthothenic acid and derivatives thereof, glycylrrhetic acid and derivatives thereof, nicotinic acid esters such as benzyl nicotinate, cyclosporins, carpronium chloride, cepharanthine, oxendolone, diazoxide, minoxidil, and ethynylesteradiol; antibacterial agents such as hinokitiol, hexachlorophen, phenol, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide, and bithionol; refrigerants such as menthol; drugs such as salicylic acid, zinc and derivatives, thereof, and lactic acid and alkyl esters thereof; organic acids such as citric acid; amino acids such as arginine; oil components such as olive oil, squalane, fluid paraffine, isopropyl myristate, higher fatty acids, and higher alcohols; polyhydric alcohols such as glycerine and propylene glycol; nonionic surfactants; cationic surfactants; perfumes; antioxidants; UV-ray absorbers; dyes; alcohols such as ethanol, benzyl alcohol, and isopropyl alcohol; water; humectants; and thickeners and the like. 
     The hair revitalizing tonic composition of the present invention can be in any preparation form, provided that it can be applied to the outer skin, such as a liquid, an emulsion, an ointment, a cream, a gel, or a spray, and can be used in such forms as a tonic, conditioner, or a scalp treatment. 
     The hair revitalizing tonic composition containing an amine oxide according to the present invention has an excellent hair loss prevention and hair revitalizing effect. 
     Also, the hair revitalizing tonic composition containing an amine oxide and an anionic surfactant has an excellent hair loss prevention, and hair revitalizing effect, and at the same time, has an excellent dandruff and itchy scalp prevention effect. 
    
    
     EXAMPLES 
     The present invention is described in more detail below by referring to Examples, which in no way limit the present invention. In the following Examples, the formulation amounts are by % by weight, and the effect testing methods and evaluation methods used in the Examples are as described below. 
     Hair Loss Prevention Effect Test 
     This effect was judged by the determining the change in the number of hairs lost during hair washing, before and after using the sample. Eight persons were test as a group for each of Examples 1 to 4 and for Comparative Example 1, and 4 persons were tested as a group for each of Examples 5 to 10. The test period was 6 months, in which the sample was not used for the first 2 months, and was used during last 4 months. During the period in which the sample was used, the sample was applied to the scalp twice a day, in an amount of 2 to 4 ml for each application. During the test period, the hair loss was determined by washing the hair every other day, and counting the total number of hairs lost each week. The numbers of hairs lost during each period is given by summarizing the data of the number of hairs lost during the 2 months for which the sample was not applied, multiplied by 8 to obtain a total, and the data of the number of hairs lost during the last 2 months of the 4 months during which the sample was applied, multiplied by 8 to obtain a total, in terms of the hair loss average value ± a standard deviation. The judgement of the effect was represented as follows, based on the difference in average values obtained in the respective periods. 
     ++: Remarkable effect observed with number of hair lost being reduced by 70 or more; 
     +: Considerable effect observed with number of hairs lost being reduced by 40 or more; 
     ±: Slight effect observed with number of hairs lost being reduced by 10 or more; 
     -: No effect observed with number of hairs lost being reduced by less than 10. 
     Hair Revitalizing Effect Test 
     To determine the hair revitalizing effect of the hair revitalizing tonic composition of the present invention, the trichogram test was carried out. Five persons were tested as a group for each of Examples 1 to 4 and for Comparative Example 1, and four persons were tested as group for each of Examples 5 to 10. The sample was applied for 3 months, during which period the sample was applied to the scalp twice a day, in an amount of 2 to 4 ml for each application. Immediately before application and immediately after application for 3 months, 50 hairs were removed from the pariental region of the scalp, the hair roots of the removed hair were observed under a microscope, and the root resting period ratio (%) was calculated from the form of the hair roots, The hair revitalizing effect of each sample was based on a comparison of the increase or decrease in the resting period ratio before and after application of the sample. 
     Dandruff, Itchy Scalp Prevention Effect Test 
     Four persons were tested as a group for each of the Examples and Comparative examples. The sample was applied for 3 months, during which period the hair was washed once per day with the same shampoo, not having a drug added thereto, and the test sample was applied to the scalp twice per day, in an amount of 2 to 4 ml for each application. On completion of the test period, the dandruff on the head was collected by an aspirating device from the persons tested, and the amount of protein in the dandruff was measured. 
     Also, on completion of the test period, itching of the scalps of the persons tested was examined, and the extent of the itching was represented according to the following scores. 
     Strong itch . . . 3 
     Some itch . . . 2 
     Slight itch . . . 1 
     No itch . . . 0 
     EXAMPLES 1-10 AND COMPARATIVE EXAMPLE 1 
     The formulations of Examples 1-10 and Comparative Example 1 are shown in Tables 1 and 2, the results of the hair loss prevention effect test of Examples 1-10 and Comparative Example 1 are shown in Tables 3 to 5, the results of the hair revitalizing effect test of Examples 1-10 and Comparative Example 1 are shown in Tables 6 and 7, and the results of dandruff and itchy scalp prevention effect test of Examples 1, 8, 9, 10 and Comparative Example 1 are shown in Table 8. 
     
                       TABLE 1                                                     
______________________________________                                    
                            Compar-                                       
                            ative                                         
             Example        Example                                       
Component      1      2       3    4    1                                 
______________________________________                                    
Dimethyllaurylamine oxide                                                 
                0.2   --      --   --   --                                
Methyldioctylamine oxide                                                  
               --      0.008  --   --   --                                
Dihydroxyethylstearyl-                                                    
               --     --       0.05                                       
                                   --   --                                
amine oxide                                                               
Lauryl POE (3 mole                                                        
               --     --      --    1.0 --                                
addition)                                                                 
dimethylamine oxide                                                       
95% Ethanol    75.0   75.0    75.0 75.0 75.0                              
Purified water bal-   bal-    bal- bal- bal-                              
               ance   ance    ance ance ance                              
______________________________________                                    
 
    
     
                       TABLE 2                                                     
______________________________________                                    
             Example                                                      
Component      5      6      7    8    9    10                            
______________________________________                                    
Dimethyllaurylamine oxide                                                 
               --     --     --   0.2  --   0.2                           
Dimethyloleylamine oxide                                                  
                1.0   --     --   --   0.2  --                            
Dimethylisostearylamine                                                   
               --      0.3   --   --   --   --                            
oxide                                                                     
Decylmethyloctylamine                                                     
               --     --      0.5 --   --   --                            
oxide                                                                     
Sodium lauryl sulfate                                                     
               --     --     --    0.06                                   
                                       --   --                            
Coconut oil fatty acid                                                    
               --     --     --   --   0.1  --                            
methyltauride sodium                                                      
Monosodium N-lauroyl-                                                     
               --     --     --   --   --    0.14                         
glutamate                                                                 
95% Ethanol    75.0   75.0   75.0 75.0 75.0 75.0                          
Purified water bal-   bal-   bal- bal- bal- bal-                          
               ance   ance   ance ance ance ance                          
______________________________________                                    
 
    
     
                       TABLE 3                                                     
______________________________________                                    
             Number of hairs lost                                         
                   No appli-                                              
        No. of person                                                     
                   cation    Application                                  
Group   tested     period    period  Judgement                            
______________________________________                                    
Example 1                                                                 
        1          289 ± 45                                            
                             233 ± 55                                  
                                     +                                    
        2          500 ± 54                                            
                             378 ± 70                                  
                                     ++                                   
        3          220 ± 41                                            
                             217 ± 22                                  
                                     -                                    
        4          473 ± 54                                            
                             391 ± 62                                  
                                     ++                                   
        5          351 ± 21                                            
                             289 ± 33                                  
                                     +                                    
        6          255 ± 52                                            
                             224 ± 39                                  
                                     ±                                 
        7          117 ± 36                                            
                             113 ± 32                                  
                                     -                                    
        8          357 ± 53                                            
                             302 ± 49                                  
                                     +                                    
Example 2                                                                 
        1          355 ± 38                                            
                             246 ± 50                                  
                                     ++                                   
        2          433 ± 40                                            
                             382 ± 35                                  
                                     +                                    
        3          458 ± 56                                            
                             402 ± 46                                  
                                     +                                    
        4          313 ± 34                                            
                             332 ± 45                                  
                                     -                                    
        5          375 ± 65                                            
                             347 ± 62                                  
                                     ±                                 
        6          122 ± 15                                            
                             126 ± 14                                  
                                     -                                    
        7          497 ± 75                                            
                             476 ± 82                                  
                                     ±                                 
        8          231 ± 42                                            
                             188 ± 33                                  
                                     +                                    
Example 3                                                                 
        1          258 ± 41                                            
                             252 ± 38                                  
                                     -                                    
        2          433 ± 41                                            
                             350 ± 62                                  
                                     ++                                   
        3          501 ± 53                                            
                             455 ± 47                                  
                                     +                                    
        4          161 ± 57                                            
                             120 ± 42                                  
                                     +                                    
        5          145 ± 22                                            
                             138 ± 26                                  
                                     -                                    
        6          476 ± 76                                            
                             365 ± 52                                  
                                     ++                                   
        7          512 ± 43                                            
                             363 ± 77                                  
                                     ++                                   
        8          223 ± 22                                            
                             195 ± 24                                  
                                     ±                                 
______________________________________                                    
 
    
     
                       TABLE 4                                                     
______________________________________                                    
              Number of hairs lost                                        
                    No appli-                                             
         No. of person                                                    
                    cation   Application                                  
Group    tested     period   period  Judgement                            
______________________________________                                    
Example 4                                                                 
         1          126 ± 12                                           
                             128 ± 15                                  
                                     -                                    
         2          468 ± 42                                           
                             342 ± 54                                  
                                     ++                                   
         3          313 ± 41                                           
                             302 ± 48                                  
                                     ±                                 
         4          500 ± 56                                           
                             407 ± 62                                  
                                     ++                                   
         5          309 ± 51                                           
                             268 ± 45                                  
                                     +                                    
         6          254 ± 42                                           
                             241 ± 38                                  
                                     ±                                 
         7          497 ± 32                                           
                             415 ± 39                                  
                                     ++                                   
         8          186 ± 21                                           
                             163 ± 26                                  
                                     ±                                 
Comparative                                                               
         1          421 ± 69                                           
                             433 ± 64                                  
                                     -                                    
Example 1                                                                 
         2          423 ± 36                                           
                             417 ± 42                                  
                                     -                                    
         3          346 ± 45                                           
                             334 ± 50                                  
                                     ±                                 
         4          113 ± 21                                           
                             121 ± 18                                  
                                     -                                    
         5          277 ± 69                                           
                             260 ± 53                                  
                                     ±                                 
         6          189 ± 21                                           
                             198 ± 23                                  
                                     -                                    
         7          290 ± 36                                           
                             291 ± 43                                  
                                     -                                    
         8          567 ± 77                                           
                             531 ± 83                                  
                                     +                                    
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                       TABLE 5                                                     
______________________________________                                    
             Number of hairs lost                                         
                   No appli-                                              
        No. of person                                                     
                   cation    Application                                  
Group   tested     period    period  Judgement                            
______________________________________                                    
Example 5                                                                 
        1          482 ± 55                                            
                             378 ± 70                                  
                                     ++                                   
        2          501 ± 54                                            
                             366 ± 45                                  
                                     ++                                   
        3          186 ± 52                                            
                             143 ± 22                                  
                                     +                                    
        4          357 ± 53                                            
                             229 ± 36                                  
                                     ++                                   
Example 6                                                                 
        1          443 ± 41                                            
                             323 ± 40                                  
                                     ++                                   
        2          313 ± 34                                            
                             299 ± 23                                  
                                     ±                                 
        3          122 ± 15                                            
                             126 ± 14                                  
                                     -                                    
        4          259 ± 52                                            
                             188 ± 33                                  
                                     ++                                   
Example 7                                                                 
        1          443 ± 41                                            
                             360 ± 62                                  
                                     ++                                   
        2          261 ± 57                                            
                             220 ± 42                                  
                                     +                                    
        3          478 ± 76                                            
                             367 ± 62                                  
                                     ++                                   
        4          223 ± 18                                            
                             196 ± 20                                  
                                     ±                                 
Example 8                                                                 
        1          123 ± 11                                            
                             122 ± 13                                  
                                     -                                    
        2          463 ± 54                                            
                             371 ± 62                                  
                                     ++                                   
        3          155 ± 22                                            
                             124 ± 29                                  
                                     ±                                 
        4          357 ± 53                                            
                             251 ± 26                                  
                                     ++                                   
Example 9                                                                 
        1          333 ± 31                                            
                             282 ± 25                                  
                                     +                                    
        2          313 ± 34                                            
                             262 ± 29                                  
                                     +                                    
        3          122 ± 15                                            
                             111 ± 14                                  
                                     ±                                 
        4          231 ± 42                                            
                             148 ± 23                                  
                                     ++                                   
Example 10                                                                
        1          322 ± 31                                            
                             241 ± 32                                  
                                     ++                                   
        2          161 ± 57                                            
                             155 ± 42                                  
                                     -                                    
        3          555 ± 45                                            
                             412 ± 52                                  
                                     ++                                   
        4          213 ± 22                                            
                             195 ± 23                                  
                                     ±                                 
______________________________________                                    
 
    
     
                       TABLE 6                                                     
______________________________________                                    
           Hair root resting ratio (%)                                    
         No. of  Immediately                                              
         person  before      After                                        
Group    tested  application application                                  
                                     Judgement                            
______________________________________                                    
Example 1                                                                 
         1       24.2        21.0    ±                                 
         2       42.0        29.6    +                                    
         3       12.0        12.7    -                                    
         4       35.7        14.1    +                                    
         5       33.4        25.2    +                                    
Example 2                                                                 
         1       36.1        36.9    -                                    
         2       41.8        27.2    +                                    
         3       33.9        29.8    ±                                 
         4       21.1        18.2    ±                                 
         5       25.3        14.0    +                                    
Example 3                                                                 
         1       17.1        15.3    ±                                 
         2       40.1        31.0    +                                    
         3       19.8        16.9    ±                                 
         4       36.9        25.3    +                                    
         5       28.6        21.2    +                                    
Example 4                                                                 
         1       22.9        20.8    ±                                 
         2       38.8        31.1    +                                    
         3       43.8        27.2    +                                    
         4       25.3        20.1    +                                    
         5       14.2        15.0    -                                    
Comparative                                                               
         1       43.2        41.8    -                                    
Example 1                                                                 
         2       14.0        15.7    -                                    
         3       21.2        21.1    -                                    
         4       32.9        27.3    ±                                 
         5       38.0        40.6    -                                    
______________________________________                                    
 (+ remarkable effect, ±  weak effect, - no effect)                    
 
    
     
                       TABLE 7                                                     
______________________________________                                    
           Hair root resting ratio (%)                                    
         No. of  Immediately                                              
         person  before      After                                        
Group    tested  application application                                  
                                     Judgement                            
______________________________________                                    
Example 5                                                                 
         1       25.1        19.2    +                                    
         2       16.2        13.6    ±                                 
         3       12.0        12.5    -                                    
         4       28.6        11.1    +                                    
Example 6                                                                 
         1       32.1        29.1    ±                                 
         2       29.3        20.1    +                                    
         3       18.3        15.5    ±                                 
         4       20.9        11.2    +                                    
Example 7                                                                 
         1       25.3        14.6    +                                    
         2       40.9        30.0    +                                    
         3       18.8        17.0    ±                                 
         4       32.6        24.6    +                                    
Example 8                                                                 
         1       22.0        19.6    ±                                 
         2       44.0        30.1    +                                    
         3       28.3        20.7    +                                    
         4       25.3        19.9    +                                    
Example 9                                                                 
         1       17.0        15.1    ±                                 
         2       40.1        32.0    +                                    
         3       24.3        18.9    +                                    
         4       35.9        29.9    +                                    
 Example 10                                                               
         1       22.2        19.4    ±                                 
         2       37.8        30.1    +                                    
         3       44.8        26.2    +                                    
         4       15.2        14.9    -                                    
______________________________________                                    
 (+ remarkable effect, ± weak effect, -  no effect)                    
 
    
     
                       TABLE 8                                                     
______________________________________                                    
           Average amount of                                              
           dandruff                                                       
Group      (mg)          Itch (average score)                             
______________________________________                                    
Example 1  14.62         1.5                                              
Example 8  6.93          0.5                                              
Example 9  5.31          0.25                                             
Example 10 6.65          0.25                                             
Comparative                                                               
           19.11         2.0                                              
Example 1                                                                 
______________________________________                                    
 
    
     As apparent from the results shown in Table 3 to 7, (1) the hair revitalizing tonic composition having an amine oxide formulated therein and (2) the hair revitalizing tonic composition having an amine oxide and an anionic surfactant formulated therein were found to have an excellent hair loss prevention effect and hair revitalizing effect. 
     Also, as apparent from the result shown in Table 8, the hair revitalizing tonic composition having an amine oxide and an anionic surfactant formulated therein was found to have an excellent dandruff and itchy scalp prevention effect. 
     EXAMPLE 11 
     A lotion comprising the following composition was prepared. 
     
         ______________________________________                                    
Ingredient           Part                                                 
______________________________________                                    
95% Ethanol          50.0                                                 
Dimethyllaurylamine oxide                                                 
                     0.2                                                  
Sodium Lauryl sulfate                                                     
                      0.06                                                
Hydrogenated castor oil ethylene                                          
                     0.5                                                  
oxide (40 mole) adduct                                                    
Purified water       Balance                                              
Perfume and dye      q.s.                                                 
______________________________________                                    
 
    
     (Preparation Methods) 
     In 95% ethanol were dissolved hydrogenated castor oil ethylene oxide (40 mole) adduct, and a perfume, and then purified water was added followed by an addition of dimethyllaurylamine oxide, sodium lauryl sulfate, and a dye, and the mixture was dissolved while stirring to obtain a transparent liquid lotion. 
     EXAMPLE 12 
     A lotion comprising the following composition was prepared. 
     
         ______________________________________                                    
Ingredient           Part                                                 
______________________________________                                    
95% Ethanol          90.0                                                 
Lauroyl POE (3 mole addition)                                             
                     3.0                                                  
dimethylamine oxide                                                       
Sodium lauryl sulfate                                                     
                     1.0                                                  
Hydrogenated castor oil ethylene                                          
                     0.5                                                  
oxide (40 mole) adduct                                                    
Purified water       Balance                                              
Perfume and dye      q.s.                                                 
______________________________________                                    
 
    
     (Preparation Methods) 
     In 95% ethanol were dissolved hydrogenated castor oil ethylene oxide (40 mole) adduct, and a perfume, and then purified water was added followed by an addition of lauryl POE (3 mole addition) dimethylamine oxide, sodium lauryl sulfate, and a dye, and the mixture was dissolved while stirring to obtain a transparent liquid lotion. 
     EXAMPLE 13 
     
         ______________________________________                                    
Ingredient            Part                                                
______________________________________                                    
(A phase)                                                                 
Fluid paraffin        5.0                                                 
Cetostearyl alcohol   5.5                                                 
Glycerine monostearate                                                    
                      3.0                                                 
Polyoxyethylene (20 mole addition)                                        
                      3.0                                                 
2-octyldodecyl ether                                                      
Vitamin E acetate     0.05                                                
Propylparaben         0.3                                                 
Perfume               0.05                                                
(B phase)                                                                 
Glycerine             7.0                                                 
Dipropylene glycol    20.0                                                
Polyethylene glycol 4000                                                  
                      5.0                                                 
Sodium hexmetaphosphate                                                   
                      0.005                                               
Purified water        Balance                                             
Dimethylcetylamine oxide                                                  
                      12.0                                                
______________________________________                                    
 
    
     (Preparation Method) 
     The A phase and the B phase were respectively dissolved by heating, mixed, and then emulsified by a homomixer to obtain a hair revitalizing tonic composition in the form of an ointment. 
     EXAMPLE 14 
     
         ______________________________________                                    
Ingredient            Part                                                
______________________________________                                    
(A phase)                                                                 
Cetanol               2.0                                                 
Petrolatum            5.0                                                 
Squalane              10.0                                                
Polyoxyethylene (10 mole addition)                                        
                      2.0                                                 
monostearate                                                              
Sorbitane monooleate  1.0                                                 
Dimethylstearylamine oxide                                                
                      1.0                                                 
Perfume               0.1                                                 
(B phase)                                                                 
Glycerine             10.0                                                
20% Gluconic acid chlohexidine                                            
                      0.1                                                 
solution                                                                  
Purified water        Balance                                             
______________________________________                                    
 
    
     (Preparation Method) 
     The A phase and the B phase were respectively dissolved by heating, were mixed, and were emulsified by a homomixer to obtain a hair revitalizing tonic composition in the form of an emulsion. 
     Examples 11 to 14 were found to have an excellent hair loss prevention effect and hair revitalizing tonic effect. Also, Examples 11 and 12 further had an excellent dandruff and itchy scalp prevention effect. 
     EXAMPLE 15 
     A lotion comprising the following composition was prepared. 
     
         ______________________________________                                    
Ingredient           Part                                                 
______________________________________                                    
95% Ethanol          80.0                                                 
N,N-Dimethyl-        2.0                                                  
2-hexyldecylamine oxide                                                   
Sodium N-lauroyl glutamate                                                
                     0.8                                                  
Hydrogenated castor oil ethylene                                          
                     0.5                                                  
oxide (40 mole) adduct                                                    
Glycerol             1.0                                                  
Vitamin E acetate    0.1                                                  
Citric acid          q.s.                                                 
Sodium citrate       q.s.                                                 
EDTA.2Na             q.s.                                                 
Purified water       Balance                                              
Perfume              q.s.                                                 
______________________________________                                    
 
    
     (Preparation Method) 
     In 95% ethanol were dissolved N,N-dimethyl-2-hexyldecylamine oxide, hydrogenated castor oil ethylene oxide (40 mole) adduct and perfume, and the solution was added to water containing glycerol, citric acid, sodium citrate and EDTA.2Na dissolved therein, followed by an addition of vitamin E acetate and sodium N-lauroyl glutamate. The mixture was dissolved while stirring to obtain a transparent liquid lotion. 
     EXAMPLE 16 
     A lotion comprising the following composition was prepared. 
     
         ______________________________________                                    
Ingredient           Part                                                 
______________________________________                                    
95% Ethanol          90.0                                                 
N,N-dimethyl-2-      1.0                                                  
decyltetradecylamine oxide                                                
Sodium dodecyl sulfate                                                    
                     0.4                                                  
Hydrogenated castor oil                                                   
                     1.0                                                  
ethylene oxide (60 mole) adduct                                           
Citric acid          q.s.                                                 
Sodium citrate       q.s.                                                 
EDTA.2Na             q.s.                                                 
Purified water       Balance                                              
Perfume              q.s.                                                 
______________________________________                                    
 
    
     (Preparation Method) 
     In 95% ethanol were dissolved N.N-dimethyl-2-decyltetradecylamine oxide, hydrogenated castor oil ethylene oxide (60 mole) adduct and perfume, and the solution was added to the purified water containing citric acid, sodium citrate and EDTA.2Na dissolved therein, followed by an addition of sodium dodecylsulfate. The mixture was dissolved while stirring to obtain a transparent liquid lotion. 
     EXAMPLE 17 
     A lotion comprising the following composition was prepared. 
     
         ______________________________________                                    
Ingredient           Part                                                 
______________________________________                                    
N,N-Dimethyl-2-tetradecyl-                                                
                     1.5                                                  
hexadecylamin oxide                                                       
Glycerol             2.0                                                  
Hydrogenated castor oil ethylene                                          
                     1.0                                                  
oxide (40 mole) adduct                                                    
Perfume              q.s.                                                 
95% Ethanol          Balance                                              
______________________________________                                    
 
    
     (Preparation Method) 
     To 95% ethanol were added N,N-dimethyl-2-tetradecylhexadecylamine oxide, glycerol, hydrogenated castor oil ethylene oxide (40 mole) adduct and perfume, followed by dissolving, while stirring, to obtain a transparent liquid lotion. 
     Examples 16 and 17 were found to have, in addition to a good hair loss prevention effect and hair revitalizing effect, an excellent applicability to the hair and an excellent characteristic capable of giving a glossy, moist, and soft feeling to the hair.