Pumpable desiccated mastic
This application is a continuation-in-part of application 08/031,602, filed Mar. 15, 1993, now U.S. Pat. No. 5,510,416, incorporated herein by reference. 
    
    
     BACKGROUND OF THE INVENTION 
     In recent years, much work has been done to design spacers for insulating glass units. Metal spacers between opposing panes can conduct heat efficiently so that the insulating performance is substantially reduced. Several alternative spacer designs have been described in Popular Science, August 1992 at page 46. Another alternative spacer design which has been developed to provide a highly desirable combination of structural integrity, moisture and gas impermeability and thermal efficiency is described in EP 475,213. This spacer utilizes a metal U-channel separated from the glass panels and the exterior edge of the assembly by a thermal brake. The U-channel opens to the interior of the assembly and includes a moisture permeable adhesive having a desiccant therein on the inner bottom surface of the channel. Adhesive materials having a permeability of greater than 2 gm mm/M 2  day as determined by ASTM F-372-73 are recommended. The desiccant loaded adhesive material contemplated for use in the invention has been a polyurethane-based formulation which is formed into a soft string and applied to the U-channel. 
     It would be an advantage to have a pumpable desiccant loaded formulation which could be more easily applied to the U-channel of the EP 475,213 reference and which would effectively desiccate the insulating glass assembly over its useful life. 
     Insulating glass assemblies can be subject to accumulation of unsightly chemical &#34;fog&#34; on the interior surface of the glass panels. Fogging can be caused by off-gassing of organic materials in the spacer or from other structures in the interior of the insulating glass assembly such as painted decorative grids. Off-gassing can be caused, for instance, by incompletely dry coatings on such grids or by UV or thermally induced degradation of a polymer during the service life of the insulating glass assembly. Any desiccant loaded material which is utilized in the U-channel of EP 475,213 should not contribute to chemical fogging and, desirably, should effectively adsorb organics originating from other structures within the insulating glass assembly so as to reduce chemical fogging. 
     The desiccant containing adhesive material utilized in the U-channel structure described in EP 475,213 must also be able to withstand elevated temperature without sagging or creeping and must maintain adhesion to the channel during the service life of the unit. Because the U-channel is open, any sagging, creeping or peeling of the desiccant composition will be readily visible. 
     These numerous requirements severely limit the options available for formulating a pumpable desiccant loaded material suitable for use in spacer structures of the type disclosed in EP 475,213. 
     In U.S. Pat. No. 5,510416, the inventors of the present application disclose thermoplastic hot-melt mastic compositions which simultaneously meet rigorous pumpability, non-fogging, desiccant loading, and non-sag requirements of the open U-channel spacer structure of EP 475,213. Such compositions suitably include a resin component consisting essentially of 4-30 parts by weight of the resin component of a film former selected from the group consisting of polyisobutylene polymers having a weight average molecular weight in the range of about 35,000 to about 60,000, and mixtures of such polymers with minor amounts of a butyl rubber having a weight average molecular weight of up to about 500,000; 20-50 parts by weight of the resin component of a non-crystalline homopolymer, copolymer, terpolymer or graft copolymer comprising polypropylene; and, 0-20 parts by weight of the resin component of a low volatile UV stable tackifier compatible with the film former and polypropylene components; and an adsorbent component which includes at least 20% by weight of the composition of a moisture or moisture and volatile organic chemical adsorbing material; and 0-10% by weight of the composition of an adsorbent of volatile organic compounds. 
     SUMMARY OF THE INVENTION 
     The present invention pertains to additional thermoplastic mastic compositions similar to those disclosed in U.S. Pat. No. 5,104,416, but which are further characterized by the inclusion in the resin component of a relatively low molecular weight liquid polybutene polymer as part of the resin component of the formulation. Inclusion of the liquid polybutene polymer makes the formulations more pumpable at comparable desiccant loadings. The compositions adhere well to the U-channel material and do not flow or sag under the normal range of service conditions encountered by an insulating glass assembly. Surprisingly the liquid polybutene containing compositions of the invention can be prepared without causing fogging of the window unit, or causing the material to sag in the window unit and have satisfactory performance on exposure to UV. 
     The compositions of the invention comprise a mixture of: a resin component consisting essentially of: 
     4-75% by weight of the resin component of a film former, the film former including a liquid polybutene polymer, alone or in combination with one or both of a polyisobutylene polymer having a weight average molecular weight of about 35,000 or more, and a butyl rubber having a weight average molecular weight of up to about 500,000, said butyl rubber, if present, representing less than 50% of the film former component; 
     25-96% by weight of the resin component of a non-crystalline homopolymer, copolymer, terpolymer or graft copolymer comprising polypropylene; and, 
     0-20% by weight of the resin component of a low volatile UV stable tackifier compatible with the film former and polypropylene components; and 
     an adsorbent component comprising: 
     at least 20% by weight of the composition of a moisture or moisture and volatile organic chemical adsorbing material; and 0-10% by weight of the composition of an adsorbent of volatile organic compounds, said adsorbent component being present in an amount less than the level which will cause the composition, when tested as set forth in ASTM D-1238, Procedure B using a 1100 gram load and an 8 gram sample at 190° C., to provide a melt flow time for a piston travel of 1 inch of more than 60 seconds. Preferred compositions of the invention provide a melt flow time under the specified conditions of less than 5 seconds. 
     Insulating glass units prepared with the desiccating mastic of the invention and methods of manufacturing edge assemblies for insulating glass units by pumping heated formulations of the invention onto the edge assembly comprise further aspects of the invention disclosed herein. 
    
    
     DESCRIPTION OF THE FIGURE 
     FIG. 1 is a sectional view of the edge assembly of an insulating unit employing a pumpable mastic desiccant of the invention. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Referring to the figure there is shown in FIG. 1 an insulating unit 10, having edge assembly 12 which serves to space the glass sheets 14 and 16 to provide the compartment 18. The edge assembly 12 includes a moisture and/or gas impervious adhesive type sealant layer 20 to adhere the glass sheets 14 and 16 to legs 22, 23 of metal spacer 24. A thin layer of a desiccating formulation 30 of the invention is applied on the inner surface of leg 23 of metal spacer 24 to adsorb moisture in the compartment 18. 
     Throughout this application quantities given in percentages or parts are to be understood as percentages or parts by weight unless specified otherwise. 
     As used herein, a composition is considered &#34;pumpable&#34; if, when tested per ASTM D-1238, Procedure B using a 1100 gram load and an 8 gram sample at 190° C. (374° F.), the melt flow time of the composition is no more than 60 seconds. Melt flow time is measured using a 1 inch piston travel as mandated by section 10.1.2.5 of that ASTM procedure. Actual pumping temperatures are considerably lower, typically about 88°-121° C. (190°-250° F.), preferably about 110° C. (230° F.), but this melt flow test is considered to be a good predictor of pumpability with conventional industrial hot melt applicators. Preferably the melt flow time is no more than 15 sec. under the specified conditions. 
     In some cases, with very pumpable formulations of the invention, the 4 minute wait time of the ASTM test method may result in the composition flowing through the test apparatus before the test is initiated. In such cases the melt time value is considered to be less than 1 second for purposes of this invention. To obtain comparative melt times under such conditions a shorter wait of 1.5 minutes and a lower weight of 725 gm may be used. 
     To assure that the formulation will stay in place under normal service conditions the compositions should, at minimum show no visible sag or flow when installed in the insulating glass assembly and maintained at a temperature of at least 60° C. (140° F.) for a continuous period of at least 2 weeks. Preferably the formulation will withstand at least 70 C (158° F.) for at least 1 month. 
     Fogging may be determined in a sealed insulating glass unit per ASTM E-773, using the pass/fail specification of ASTM E-774. However, as a practical matter, a composition which passes the draft test method of ASTM subcommitte C24.15 for Hot Applied Sealants entitled &#34;Standard Test Method For Fogging of Hot Applied Insulating Glass Unit Components&#34;, dated Jun. 12, 1994, can be reasonably assured to also pass the specification of ASTM E-774. The C24.15 subcommittee draft test method has been used for testing non-fogging behavior of the inventive compositions. 
     The formulations of the invention are stable to exposure to UV as determined by no discoloration when exposed in an enclosed box exposure to light from a Sylvania Sunlamp RSM 275W UV bulb at a distance of approximately 12 inches for 72 hours. 
     The formulations of the invention may be tested for ability to dry an insulating glass unit by frost point determination. The frost point is the temperature at which condensation occurs within the sealed unit. The test method conforms to ASTM E-546. Lowering of the initially obtained frost point over time demonstrates that the formulation effectively removes moisture from the air space of the test panel. 
     Although described herein in terms of a resin component, an adsorbent component and other additives, it should be understood that this division of ingredients is used only for purposes of stating the relative quantities of ingredients and that an order of mixing of the various ingredients is not implicated thereby. Further, although it is not believed that the compositions of the invention undergo chemical reaction, the mixtures as claimed herein are to be understood as the result of mixture, whether or not some chemical reaction between the specified components takes place upon mixture. 
     Resin Component 
     Film Former 
     The film former component used in the invention provides low temperature flexibility. In accordance with the present invention, the film former includes at least 1%, and up to 100% of the film former component of a liquid polybutene polymer. That is, their pour point as determined by ASTM D-97 is below 70° F. (21° C.). The liquid character of these polymers makes it very surprising that they can be incorporated into the inventive compositions at any levels. Such polymers are copolymers of isobutylene with but-1-ene and/or but-2-ene. Typically these polymers will have a weight average molecular weight of from 370 to about 5000, more preferably from about 900 to about 3000. Such polymers are incorporated into the composition at a level which, taking into account the other ingredients in the resin component of the formulation and the desiccant level employed, produces a formulation which does not sag, does not deteriorate on exposure to UV, does not fog and is pumpable as defined herein. In some formulations this level may be as high as 100% of the film former component, especially for the upper end of the molecular weight range specified. In general it is preferred that the liquid polybutene polymer be employed at a level of 1-50% of the film former component. 
     Polyisobutylene polymers having a number average molecular weight of about 35,000 or more, preferably 35,000-60,000, most preferably from about 50 to about 56,000, and/or a butyl rubber (weight average molecular weight up to about 500,000) make up the balance of the film former component. If used, the butyl rubber, and any polyisobutylene polymers having weight average molecular weights above 60,000, are desirably limited to an amount no more than 50% of the film former component. 
     Suitable liquid polybutenes are sold by Amoco under the trademark Indopol®, and by Exxon under the trademark Parapol®. A suitable polyisobutylene product is Vistanex™ LMMH, sold by Exxon. A suitable butyl rubber, if used, is Butyl 268, sold by Exxon. 
     Propylene Polymer 
     The propylene polymer functions to give the formulation the cohesive strength and heat resistance necessary for use as a desiccating material in an open U-channel insulating glass assembly of the type shown in FIG. 1. It must have a low volatiles content, be compatible with a film former and must be non-crystalline. Various propylene polymers are suitable such as the Rextac® APO series polymers including Rextac® 2100 series homopolymers, 2500 series ethylene-propylene copolymers and 2700 series butene-propylene copolymers and terpolymers. These products typically have a number average molecular weight (M n ) in the range of about 7,000-14,000; weight average molecular weight (M w ) in the range of about 35,000-90,000; Z average (M z ) in the range of about 13,000-33,000 and polydispersity (MWD) in the range of about 4.9-6.2. Other polymers which may be used are sold under the trademark Eastoflex by Eastman Chemical, such as Eastoflex T1035, a propylene-ethylene-butene terpolymer having a M n  of about 4,000 and a M w  of about 16,000; Eastman D-178; Eastman E 1060; and K-Tac® A-100 amorphous polypropylene sold by Baychem. 
     Tackifying Resins 
     The use of a tackifying resin is preferably avoided entirely. It has been found that most tackifiers, even when extensively vacuum stripped, can contribute substantially to chemical fogging. Many tackifiers are also incompatible with the film former/polymer combination used in the invention. In the preferred formulations of the invention, good adhesion to the substrate can be obtained without use of any tackifier. If a tackifying resin is used, it is preferably one which has good UV resistance, low volatiles, and is compatible in the formulation. Hydrogenated wood rosin, such as Foral 105 sold by Hercules, or hydrocarbon tackifying resins, such as Regal Rez 1094 hydrogenated hydrocarbon tackifying resin and Exxon ECR 165C C 5  /C 9  tackifying resin, are recommended if a tackifier is employed. 
     Adsorbent Component 
     The adsorbent component may be one or more of the known moisture adsorbing materials, alone or in combination with adsorbents of low molecular weight organics, such as natural zeolite (e.g. chabasite, gumerinite, levynite, erinitc, mordenite and analcite), molecular sieves, silica gel, silica-magnesia gel, silica-alumina gel, activated carbon, activated alumina, etc. At least 20%, preferably at least 30%, by weight of the composition is a moisture adsorbing desiccant. Preferably the desiccant content is between about 30 and 65% by weight of the composition. Suitably, the adsorbent component also includes up to about 10%, preferably 5-10%, of an adsorbent of volatile organics. An adsorbent component which functions to remove both moisture and volatile organics, such as molecular sieve 13x, may also be employed as part or all of the adsorbent component of the formulation. The maximum level of adsorbent is the level at which the composition becomes unpumpable as defined herein. This level may be 70% or higher depending on the particular resin component used and the presence or absence of any filler ingredients. A preferred component is a mixture of about 30-65%, more preferably about 40-60% by weight of the composition of a desiccant such as molecular sieve 3A or 4A and 8-10% by weight of the composition of a desiccant/organic vapor adsorbent, such as molecular sieve 13X. Desirably the desiccant and chemical adsorbent components are in the form of a powder of 50-100 mesh or less. 
     Other Additives 
     The formulation may include other common additives such as fillers, antioxidants, UV and thermal stabilizers, adhesion promoters and the like, provided that they do not substantially interfere with the performance of the formulation for its desired purpose. In particular, optional fillers should not increase viscosity of a mastic beyond that practical for pumpability and all other additives must be sufficiently non-volatile to withstand devolatilization of the formulated composition. A suitable extending filler is a calcium carbonate filler, such as Hubercarb™ Q-325 sold by J. M. Huber, which may be employed at levels up to about 10% by weight of the composition, preferably about 5% or less. 
     Processing 
     The formulation is suitably made by heating and mixing all ingredients at an elevated temperature, typically 121°-140° C. (250°-284° F.), until a smooth and uniform mixture has been obtained. Higher temperatures may be required when butyl rubber is incorporated into the composition. Devolatilization of the heated formulation may be accomplished before or after addition of the adsorbent. When the adsorbent includes a chemical adsorbent as well as a desiccant, it is desirable that the mixture be devolatilized first, before addition of the adsorbent components. Suitably, the mixture is heated to about 150° C. (302° F.), evacuated to a vacuum pressure of less than 571.8 mm Hg (22 inches Hg) for at least 30 minutes, after which the adsorbent is added and the formulation then subjected to a second stage devolatilization of at least the same extent. The formulated mastic may ben be filtered directly into dry containers which are sealed until use. 
     The invention is illustrated by reference to the following non-limiting examples. 
     EXAMPLES 
     Devolatilized formulations were prepared from the ingredients shown in Table 1 below, where quantities are in parts by weight. Melt flow times as specified above are also provided in Table 1. The Comparative Example is a commercial product prepared in accordance with U.S. Pat. No. 5,510,416. All invention examples pass non-sag, non-fogging and UV stability criteria as described above. 
     
                       TABLE 1                                                     
______________________________________                                    
            Comparative                                                   
Ingredients Example    Ex. 1   Ex. 2                                      
                                    Ex. 3 Ex. 4                           
______________________________________                                    
Vistanex ® LMMH                                                       
              4.45                                                        
.-                                                                        
.-                                                                        
.-                                                                        
.-                                                                        
Indopol ® H-100                                                       
.-            4.45                                                        
.-                                                                        
.-                                                                        
.-                                                                        
Indopol ® H-1500                                                      
.-                                                                        
.-            4.45                                                        
.-                                                                        
.-                                                                        
Indopol ® H-300                                                       
.-                                                                        
.-                                                                        
.-            4.45     4.45                                               
Calcium carbonate                                                         
              5.49     5.49    5.99 6.90  6.90                            
Eastman D 178 42.74    42.74   42.74                                      
                                    42.74 37.74                           
Irganox 1076 *                                                            
              0.50     0.50                                               
.-                                                                        
.-                                                                        
.-                                                                        
Carbon Black **                                                           
              0.02     0.02    0.02 0.01  0.01                            
TiO.sub.2 **  1.80     1.80    1.80 0.90  0.90                            
3A Mol. sieve 36.00    36.00   36.00                                      
                                    36.00 41.00                           
13X Mol. sieve                                                            
              9.00     9.00    9.00 9.00  9.00                            
4A Mol. sieve                                                             
.-                                                                        
.-                                                                        
.-                                                                        
.-                                                                        
.-                                                                        
Test Results                                                              
Melt flow time (sec)                                                      
1100 gm load  5.1        3      2.4       &lt;1                              
 725 gm load  7.6                         5.3                             
______________________________________                                    
 * Optional antioxidant sold by Ciba Geigy                                
 ** Optional component                                                    
 
    
     Although the present invention has been described in terms of specific embodiments, it is anticipated that alterations and modifications thereof will no doubt become apparent to those skilled in the art. It is therefore intended that the following claims be interpreted as covering all such alterations and modifications as fall within the true spirit and scope of the invention. 
     
         __________________________________________________________________________
SEQUENCE LISTING                                                          
(1) GENERAL INFORMATION:                                                  
(iii) NUMBER OF SEQUENCES: 5                                              
(2) INFORMATION FOR SEQ ID NO:1:                                          
(i) SEQUENCE CHARACTERISTICS:                                             
(A) LENGTH: 1539 base pairs                                               
(B) TYPE: nucleic acid                                                    
(C) STRANDEDNESS: single                                                  
(D) TOPOLOGY: linear                                                      
(ii) MOLECULE TYPE: cDNA                                                  
(iii) HYPOTHETICAL: NO                                                    
(iv) ANTI-SENSE: NO                                                       
(ix) FEATURE:                                                             
(A) NAME/KEY: CDS                                                         
(B) LOCATION: 1..1539                                                     
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1:                                   
ATGGACCTCAAGGAAAGCCCCAGTGAGGGCAGCCTGCAACCTTCTAGC48                        
MetAspLeuLysGluSerProSerGluGlySerLeuGlnProSerSer                          
151015                                                                    
ATCCAGATCTTTGCCAACACCTCCACCCTCCATGGCATCCGCCACATC96                        
IleGlnIlePheAlaAsnThrSerThrLeuHisGlyIleArgHisIle                          
202530                                                                    
TTCGTGTATGGGCCGCTGACCATCCGGCGTGTGCTGTGGGCAGTGGCC144                       
PheValTyrGlyProLeuThrIleArgArgValLeuTrpAlaValAla                          
354045                                                                    
TTCGTGGGCTCTCTGGGCCTGCTGCTGGTGGAGAGCTCTGAGAGGGTG192                       
PheValGlySerLeuGlyLeuLeuLeuValGluSerSerGluArgVal                          
505560                                                                    
TCCTACTACTTCTCCTACCAGCATGTCACTAAGGTGGACGAAGTGGTG240                       
SerTyrTyrPheSerTyrGlnHisValThrLysValAspGluValVal                          
65707580                                                                  
GCTCAAAGCCTGGTCTTCCCAGCTGTGACCCTCTGTAACCTCAATGGC288                       
AlaGlnSerLeuValPheProAlaValThrLeuCysAsnLeuAsnGly                          
859095                                                                    
TTCCGGTTCTCCAGGCTCACCACCAACGACCTGTACCATGCTGGGGAG336                       
PheArgPheSerArgLeuThrThrAsnAspLeuTyrHisAlaGlyGlu                          
100105110                                                                 
CTGCTGGCCCTGCTGGATGTCAACCTGCAGATCCCGGACCCCCATCTG384                       
LeuLeuAlaLeuLeuAspValAsnLeuGlnIleProAspProHisLeu                          
115120125                                                                 
GCTGACCCCTCCGTGCTGGAGGCCCTGCGGCAGAAGGCCAACTTCAAG432                       
AlaAspProSerValLeuGluAlaLeuArgGlnLysAlaAsnPheLys                          
130135140                                                                 
CACTACAAACCCAAGCAGTTCAGCATGCTGGAGTTCCTGCACCGTGTG480                       
HisTyrLysProLysGlnPheSerMetLeuGluPheLeuHisArgVal                          
145150155160                                                              
GGCCATGACCTGAAGGATATGATGCTCTACTGCAAGTTCAAAGGGCAG528                       
GlyHisAspLeuLysAspMetMetLeuTyrCysLysPheLysGlyGln                          
165170175                                                                 
GAGTGCGGCCACCAAGACTTCACCACAGTGTTTACAAAATATGGGAAG576                       
GluCysGlyHisGlnAspPheThrThrValPheThrLysTyrGlyLys                          
180185190                                                                 
TGTTACATGTTTAACTCAGGCGAGGATGGCAAACCTCTGCTCACCACG624                       
CysTyrMetPheAsnSerGlyGluAspGlyLysProLeuLeuThrThr                          
195200205                                                                 
GTCAAGGGGGGGACAGGCAACGGGCTGGAGATCATGCTGGACATTCAG672                       
ValLysGlyGlyThrGlyAsnGlyLeuGluIleMetLeuAspIleGln                          
210215220                                                                 
CAGGATGAGTACCTGCCCATCTGGGGAGAGACAGAGGAAACGACATTT720                       
GlnAspGluTyrLeuProIleTrpGlyGluThrGluGluThrThrPhe                          
225230235240                                                              
GAAGCAGGAGTGAAAGTTCAGATCCACAGTCAGTCTGAGCCACCTTTC768                       
GluAlaGlyValLysValGlnIleHisSerGlnSerGluProProPhe                          
245250255                                                                 
ATCCAAGAGCTGGGCTTTGGGGTGGCTCCAGGGTTCCAGACCTTTGTG816                       
IleGlnGluLeuGlyPheGlyValAlaProGlyPheGlnThrPheVal                          
260265270                                                                 
GCCACACAGGAGCAGAGGCTCACATACCTGCCCCCACCGTGGGGTGAG864                       
AlaThrGlnGluGlnArgLeuThrTyrLeuProProProTrpGlyGlu                          
275280285                                                                 
TGCCGATCCTCAGAGATGGGCCTCGACTTTTTTCCTGTTTACAGCATC912                       
CysArgSerSerGluMetGlyLeuAspPhePheProValTyrSerIle                          
290295300                                                                 
ACCGCCTGTAGGATTGACTGTGAGACCCGCTACATTGTGGAAAACTGC960                       
ThrAlaCysArgIleAspCysGluThrArgTyrIleValGluAsnCys                          
305310315320                                                              
AACTGCCGCATGGTTCACATGCCAGGGGATGCCCCTTTTTGTACCCCT1008                      
AsnCysArgMetValHisMetProGlyAspAlaProPheCysThrPro                          
325330335                                                                 
GAGCAGCACAAGGAGTGTGCAGAGCCTGCCCTAGGTCTGTTGGCGGAA1056                      
GluGlnHisLysGluCysAlaGluProAlaLeuGlyLeuLeuAlaGlu                          
340345350                                                                 
AAGGACAGCAATTACTGTCTCTGCAGGACACCCTGCAACCTAACCCGC1104                      
LysAspSerAsnTyrCysLeuCysArgThrProCysAsnLeuThrArg                          
355360365                                                                 
TACAACAAAGAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCC1152                      
TyrAsnLysGluLeuSerMetValLysIleProSerLysThrSerAla                          
370375380                                                                 
AAGTACCTTGAGAAGAAATTTAACAAATCAGAAAAATATATCTCAGAG1200                      
LysTyrLeuGluLysLysPheAsnLysSerGluLysTyrIleSerGlu                          
385390395400                                                              
AACATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGAGACA1248                      
AsnIleLeuValLeuAspIlePhePheGluAlaLeuAsnTyrGluThr                          
405410415                                                                 
ATTGAACAGAAGAAGGCGTATGAAGTTGCTGCCTTACTTGGTGATATT1296                      
IleGluGlnLysLysAlaTyrGluValAlaAlaLeuLeuGlyAspIle                          
420425430                                                                 
GGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCTTACAATACTA1344                      
GlyGlyGlnMetGlyLeuPheIleGlyAlaSerIleLeuThrIleLeu                          
435440445                                                                 
GAGCTCTTTGATTATATTTATGAGCTGATCAAAGAGAAGCTATTAGAC1392                      
GluLeuPheAspTyrIleTyrGluLeuIleLysGluLysLeuLeuAsp                          
450455460                                                                 
CTGCTTGGCAAAGAGGAGGACGAAGGGAGCCACGATGAGAATGTGAGT1440                      
LeuLeuGlyLysGluGluAspGluGlySerHisAspGluAsnValSer                          
465470475480                                                              
ACTTGTGACACAATGCCAAACCACTCTGAAACCATCAGTCACGCTGTG1488                      
ThrCysAspThrMetProAsnHisSerGluThrIleSerHisAlaVal                          
485490495                                                                 
AACGTGCCCCTGCAGACGACCCTGGGGACCTTGGAGGAGATTGCCTGC1536                      
AsnValProLeuGlnThrThrLeuGlyThrLeuGluGluIleAlaCys                          
500505510                                                                 
TGA1539                                                                   
(2) INFORMATION FOR SEQ ID NO:2:                                          
(i) SEQUENCE CHARACTERISTICS:                                             
(A) LENGTH: 512 amino acids                                               
(B) TYPE: amino acid                                                      
(D) TOPOLOGY: linear                                                      
(ii) MOLECULE TYPE: protein                                               
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2:                                   
MetAspLeuLysGluSerProSerGluGlySerLeuGlnProSerSer                          
151015                                                                    
IleGlnIlePheAlaAsnThrSerThrLeuHisGlyIleArgHisIle                          
202530                                                                    
PheValTyrGlyProLeuThrIleArgArgValLeuTrpAlaValAla                          
354045                                                                    
PheValGlySerLeuGlyLeuLeuLeuValGluSerSerGluArgVal                          
505560                                                                    
SerTyrTyrPheSerTyrGlnHisValThrLysValAspGluValVal                          
65707580                                                                  
AlaGlnSerLeuValPheProAlaValThrLeuCysAsnLeuAsnGly                          
859095                                                                    
PheArgPheSerArgLeuThrThrAsnAspLeuTyrHisAlaGlyGlu                          
100105110                                                                 
LeuLeuAlaLeuLeuAspValAsnLeuGlnIleProAspProHisLeu                          
115120125                                                                 
AlaAspProSerValLeuGluAlaLeuArgGlnLysAlaAsnPheLys                          
130135140                                                                 
HisTyrLysProLysGlnPheSerMetLeuGluPheLeuHisArgVal                          
145150155160                                                              
GlyHisAspLeuLysAspMetMetLeuTyrCysLysPheLysGlyGln                          
165170175                                                                 
GluCysGlyHisGlnAspPheThrThrValPheThrLysTyrGlyLys                          
180185190                                                                 
CysTyrMetPheAsnSerGlyGluAspGlyLysProLeuLeuThrThr                          
195200205                                                                 
ValLysGlyGlyThrGlyAsnGlyLeuGluIleMetLeuAspIleGln                          
210215220                                                                 
GlnAspGluTyrLeuProIleTrpGlyGluThrGluGluThrThrPhe                          
225230235240                                                              
GluAlaGlyValLysValGlnIleHisSerGlnSerGluProProPhe                          
245250255                                                                 
IleGlnGluLeuGlyPheGlyValAlaProGlyPheGlnThrPheVal                          
260265270                                                                 
AlaThrGlnGluGlnArgLeuThrTyrLeuProProProTrpGlyGlu                          
275280285                                                                 
CysArgSerSerGluMetGlyLeuAspPhePheProValTyrSerIle                          
290295300                                                                 
ThrAlaCysArgIleAspCysGluThrArgTyrIleValGluAsnCys                          
305310315320                                                              
AsnCysArgMetValHisMetProGlyAspAlaProPheCysThrPro                          
325330335                                                                 
GluGlnHisLysGluCysAlaGluProAlaLeuGlyLeuLeuAlaGlu                          
340345350                                                                 
LysAspSerAsnTyrCysLeuCysArgThrProCysAsnLeuThrArg                          
355360365                                                                 
TyrAsnLysGluLeuSerMetValLysIleProSerLysThrSerAla                          
370375380                                                                 
LysTyrLeuGluLysLysPheAsnLysSerGluLysTyrIleSerGlu                          
385390395400                                                              
AsnIleLeuValLeuAspIlePhePheGluAlaLeuAsnTyrGluThr                          
405410415                                                                 
IleGluGlnLysLysAlaTyrGluValAlaAlaLeuLeuGlyAspIle                          
420425430                                                                 
GlyGlyGlnMetGlyLeuPheIleGlyAlaSerIleLeuThrIleLeu                          
435440445                                                                 
GluLeuPheAspTyrIleTyrGluLeuIleLysGluLysLeuLeuAsp                          
450455460                                                                 
LeuLeuGlyLysGluGluAspGluGlySerHisAspGluAsnValSer                          
465470475480                                                              
ThrCysAspThrMetProAsnHisSerGluThrIleSerHisAlaVal                          
485490495                                                                 
AsnValProLeuGlnThrThrLeuGlyThrLeuGluGluIleAlaCys                          
500505510                                                                 
(2) INFORMATION FOR SEQ ID NO:3:                                          
(i) SEQUENCE CHARACTERISTICS:                                             
(A) LENGTH: 4 amino acids                                                 
(B) TYPE: amino acid                                                      
(C) STRANDEDNESS:                                                         
(D) TOPOLOGY: linear                                                      
(ii) MOLECULE TYPE: peptide                                               
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:3:                                   
PheMetArgPhe                                                              
(2) INFORMATION FOR SEQ ID NO:4:                                          
(i) SEQUENCE CHARACTERISTICS:                                             
(A) LENGTH: 8 amino acids                                                 
(B) TYPE: amino acid                                                      
(C) STRANDEDNESS:                                                         
(D) TOPOLOGY: linear                                                      
(ii) MOLECULE TYPE: peptide                                               
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:4:                                   
PheLeuPheGlnProGlnArgPhe                                                  
15                                                                        
(2) INFORMATION FOR SEQ ID NO:5:                                          
(i) SEQUENCE CHARACTERISTICS:                                             
(A) LENGTH: 18 amino acids                                                
(B) TYPE: amino acid                                                      
(C) STRANDEDNESS:                                                         
(D) TOPOLOGY: linear                                                      
(ii) MOLECULE TYPE: peptide                                               
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:5:                                   
AlaGlyGluGlyLeuSerSerProPheTrpSerLeuAlaAlaProGln                          
151015                                                                    
ArgPhe                                                                    
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