A300
Flight Crew Last 90 Days 200; Flight Crew Total 10000; Flight Crew Type 700
Aircraft Equipment Problem Critical
Air Traffic Control Provided Assistance; Flight Crew FLC Overrode Automation; Flight Crew Requested ATC Assistance / Clarification; Flight Crew Landed in Emergency Condition
Aircraft
Enroute at 34;000 feet the Number One Pressure Controller faulted.  We followed ECAM procedures and selected the Number Two Pressure Controller.  It also failed shortly after the first.  We again followed ECAM procedures; used the Manual Pressure Controller; and descended on oxygen masks to 10;000 feet under Center control and received vectors to destination. We followed all ECAMs; appropriate checklists and performed an uneventful ILS.
No additional information contained in this report.
During cruise flight the crew of an A300 lost the Number 1 Pressure Controller; followed by the loss of the Number 2 Pressure Controller; and descended to 10;000 on oxygen masks using the Manual Pressure Controller.