A320
Flight Crew Air Transport Pilot (ATP); Flight Crew Instrument; Flight Crew Multiengine
Deviation / Discrepancy - Procedural Published Material / Policy; Flight Deck / Cabin / Aircraft Event Illness / Injury; Flight Deck / Cabin / Aircraft Event Smoke / Fire / Fumes / Odor
Flight Crew Overcame Equipment Problem; Flight Crew Took Evasive Action
Aircraft
On initial climb out from ZZZ; the flight attendants called me to inform me that the B and D (AFT) flight attendants were feeling disoriented and had headaches. As we passed through 10;000 feet; they began to smell an odor of alcohol and nail polish remover that made them feel uneasy. As they came forward to inform the A and C (FWD) flight attendants; these flight attendants confirmed to them that they had a similar feeling on the way to ZZZ; but did not share that with anyone else. I followed our QRH for fume removal and the odor did not dissipate; but remained mild while in cruise for the remainder of the flight. I had the AFT flight attendants come forward to the cockpit and administered oxygen. This had the desired effect and they both started to feel better. I had them stay in the forward galley for the remainder of the flight. As we started our descent into ZZZ1; I asked them to return to the AFT galley and [let] me know if the odor changed in intensity. Within in few minutes; they called to inform me that the smell was intensifying and that they were again becoming disoriented. At this time; the passengers; starting with those seated in the last rows; started to complain about the odor and quickly the rest of the plane began to complain.  I told the flight attendants to leave the AFT galley and to take a seat in the cabin for the remainder of the flight. Hence; they were not in their safety positions on landing.It appears there was deice fluid trapped in the airplane that may have caused the event and as the airplane pitch attitude changed; so did the trap fluid. A review of the deice personnel and their application methods may be prudent to avoid the injection of deice fluid and subsequent trapping inside the airframe.
A320 Captain reported flight attendants experienced headaches and disoriented feelings from noxious odor in the passenger cabin.