EMB ERJ 145 ER/LR
Flight Crew Multiengine; Flight Crew Instrument; Flight Crew Air Transport Pilot (ATP)
Physiological - Other; Situational Awareness; Time Pressure; Troubleshooting; Workload
Aircraft Equipment Problem Critical; Deviation / Discrepancy - Procedural MEL / CDL; Deviation / Discrepancy - Procedural Maintenance; Deviation / Discrepancy - Procedural Published Material / Policy; Inflight Event / Encounter Other / Unknown
Air Traffic Control Provided Assistance; Flight Crew FLC complied w / Automation / Advisory; Flight Crew Landed in Emergency Condition; Flight Crew Requested ATC Assistance / Clarification
Aircraft
E2/anti-ice fail EICAS Message; open inscription was no longer illuminated on anti-ice button associated with MEL and per MEL this should have been inhibited. We selected ice detection override to ALL per QRH. Next engine air inlet was not selected per QRH due to MEL and valve secured open by Maintenance per MEL. We contacted Dispatch via ACARS and stayed clear of icing as per the QRH procedure. While at FL230 got wing anti-ice fail EICAS message; not associated to the MEL. This time QRH directed us to cycle wing anti-ice which solved the problem. END QRH.We felt a bump in cabin pressure and observed an abnormal cabin pressure readout. Thinking this was part of MEL we started a decent to FL190. Around FL210 both FO (First Officer) and I feel signs of hypoxia and don mask and established communication and checking EICAS we see that cabin alt is climbing rapidly at which time we [notify ATC] and execute emergency descent procedure to 13;000 per ATC we request 10;000; during emergency decent we get cabin alt warning EICAS message; leveling at 10;000 feet cabin pressure is still in the red so we request 7;000 to lower the cabin alt. I make a PA announcement to calm passengers and continue to ZZZ where we landed and taxied to gate and met by Fire Rescue; Maintenance; and airport operations.Add a check of cabin pressure to QRH.
EMB-145 First Officer reported a pressurization failure at cruise altitude and signs of hypoxia on descent.