A321
Flight Crew Air Transport Pilot (ATP)
Time Pressure; Workload; Troubleshooting
Aircraft Equipment Problem Critical
Air Traffic Control Provided Assistance; Flight Crew Overcame Equipment Problem; Flight Crew Requested ATC Assistance / Clarification; General Maintenance Action
Aircraft
Dispatched with one pack inop. Second pack failed at FL330. Descent to FL100; pressurization stabilized at FL100. Reinstated pack; and continued at FL220. No further issues.
Airbus pilot reported a loss of cabin pressure due to loss of the one remaining pack.