EMB ERJ 190/195 ER/LR
Flight Crew Instrument; Flight Crew Air Transport Pilot (ATP); Flight Crew Multiengine
Time Pressure; Distraction
Aircraft Equipment Problem Critical
Flight Crew Overcame Equipment Problem
Aircraft; MEL
Flight dispatched with BLEED 1 INOP.  Cruising at FL200; received BLEED 2 FAIL. Received ATC clearance and descended to 10;000 feet. Handled the BLEED 2 FAIL IAW (In Accordance With) QRH.Cabin pressure did not rise above 10;000 feet.
Aircraft was dispatched with Bleed 1 inoperative. During cruise flight the anti ice system activated at 20;000 feet. and caused the Bleed 2 Fail message to appear. Cabin began climbing as we could not maintain pressurization. Asked ATC for immediate descent and were cleared for 10;000 feet. [ATC was not advised]. Ran QRH for messages and continued flight at 10;000 feet to destination with no further issue.
EMB-190 flight crew reported a bleed valve condition which compromised cabin pressurization; necessitating a descent to a lower altitude.