Flight Crew Multiengine; Flight Crew Instrument; Flight Crew Air Transport Pilot (ATP)
Troubleshooting; Workload
Aircraft Equipment Problem Less Severe; Flight Deck / Cabin / Aircraft Event Smoke / Fire / Fumes / Odor
Flight Crew Landed in Emergency Condition
Aircraft
Departing ZZZ; received a No. 2 engine bleed leak message on pneumatic panel; with EICAS message. Deselected engine bleed source per QRH procedure. Continued flight after considering air return to ZZZ as bleed leak warning went out shortly after deselecting right engine bleed.  Later in flight at FL250; suddenly noticed acrid strong odor. Captain called flight attendant on interphone and confirmed some smoke and strong odor present in cabin. Decided to perform 'smoke in cockpit' memory items. During this procedure apparently Captain's mask interphone failed and he was unable to communicate with O2 mask on. Pilot Flying assumed flying and ATC communication responsibilities and coordinating descent and weather deviation with ATC. [Requested ATC priority handling]. During descent eventually Pack 1 overheat EICAS message annunciation. Smoke and odor dissipated so O2 masks removed and normal crew communication resumed. Continued to destination as no longer producing smoke and no odor detected in cockpit and confirmed by flight attendant in cabin. Landed uneventfully in ZZZ1 with good priority handling by ATC and some weather deviation due to local rain showers. [I] understand that the left air conditioning pack failed; causing smoke and odor noted.
At FL250 with right pack and bleed deselected; began to get smoke throughout aircraft. Donned masks and [requested priority handling] with ZZZ ATC. We received clearance direct to ZZZ1 from about 80 miles out and descended to 10;000'. After about 2-3 minutes; smoke dissipated and did not reappear. Uneventful landing.
EMB145 flight crew reported a fume event of smoke and strong odor in the cabin occurred in cruise following a number 2 engine bleed leak EICAS message.