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spec: Manufactured products typically had quite high ratios of value to weight , and even the quite high transatlantic shipping costs of the 1790s offered comparatively little natural protection for American producers of such products . We want to join with them to come closer together around basic principles of democracy and law , open markets and a commitment to peace because in this era , our security , prosperity and freedom hinge on whether others , too , have access to these blessings . Using both in vitro systems and laboratory animals , they investigate the cell-specific expression and regulation of these enzymes , their intracellular trafficking , mode / site of association and activation , and their interaction with the substrates they cleave . The designs will be tested both in vitro and in vivo . Physical aspects of viral life cycles : ours is a joint group [ co-directed by Professor Charles M. Knobler ] doing theory and experiment on representative viruses from the bacterial , plant , and animal kingdoms , focusing on the generic properties of their structures and replication , both in vitro and in vivo . The analyses showed that these antibodies were as effective , or more , as those produced by " protected " African adults in eliminating the parasites , both in vitro in cultures as well as in vivo in a humanised mouse model . The question in every case is whether the words used are used in such circumstances and are of such a nature as to create a clear and present danger that they will bring about the substantive evils that Congress has a right to prevent . Mostly driven by clock time , they rarely operate in the flow of time . And , to cap it all , the railroads , pushed to the limit of their capacity by the enormous export trade of New York and by the demands of her constantly enlarging local business , sought to divert some of her heavy export traffic by establishing differential rates against her in favor of other cities , where it could be handled at less expense to themselves and with less interference with high-class freights .