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spec: Between 1510 and 1640 , Franciscans , Jesuits , Dominicans , Augustinians , Carmelites and Theatines all established houses in Asia . Benefits to the 750,000 implant recipients each year are twofold : 1 ) the antimicrobial agent in the coating has been proven in tests to kill bacteria or greatly inhibit its growth in the body , helping to prevent dangerous and costly post-surgical infections , and 2 ) the water-based deposition process coupled with the bioactive antimicrobial agent provides an advanced method for applying thin films containing calcium-phosphate coatings — a natural component of bone — to artificial joints , allowing for enhanced bone bonding and helping to avoid rejection of the implant by the body . A smart move for small business because typically , they cannot achieve sales volume levels to be a low price favorite . Though it may be said that these restrictions are not designed to operate as punishments , and that , in the making of this general law , no particular individual was aimed at , yet there results from it a distinction injurious to the particular class of persons affected by it - - - necessarily injurious , since the continuance of the law can be justified only by supposing them to be dangerous and disloyal . Three notetakers are present , the third of whom is required to take the fullest possible record of the meeting . A total of 156 firms , mostly local firms with one office , responded . Though patient autonomy is important , it does not compel physicians to offer dangerous or unhelpful interventions . He vaguely suggested that we should somehow , sometime , give massive amounts of money to the least effective programs of NASA to conduct dangerous and expensive missions that offer far less in terms of scientific discovery than the unmanned missions that could be sent on a fraction of that budget .