source: [word=managers] [lemma=have] [□=□]
destination: [word=managers] [lemma=have] [tag=□]
spec: The restructuring that stripped out layers of middle management from many organisations during the early 1990s was consolidated as the decade went on , and the burden of responsibility placed on first-line managers has grown in recent years with little sign of a return to the multi-layered hierarchies of old . Used by researchers around the world , these materials provide raw data for evaluating changes in the physical and biological environment that occurred before human influences . Duke and others helped create a market for Durham-area tobacco products that eventually would turn North Carolina into the heart of an international tobacco empire . After much agonizing , the senior managers had decided to let her go - - a decision that I agreed with , although I 'd said it was theirs to make . Under Goh , the company 's annual travel budget is in the hundreds of thousands of dollars and managers have visited more than a dozen countries . Since then , fund managers have continued to take a hard line against shareholder discounts . The case studies section contains a growing set of examples of protected area financing , demonstrating how the information contained in the guidelines is put into practice , the barriers protected areas face on the ground and the ways protected area managers have overcome these barriers . Whenever possible , we recommend using a primer that anneals only to defined sequences in particular RNAs ( sequence-specific primers ) rather than to the entire RNA population in the sample ( e.g ., random hexamers or oligo ( dT ) primer ) . The ' Five Interested Parties ' ( FIPs ) group consisting of the US , EC , Australia , Brazil and India also held intense meetings on the sidelines .