scrub typhus infection is a common febrile disorder presenting in the tropical region with propensity to involve different systems . amongst them the cardio - respiratory system is involved in a significant proportion resulting in various manifestations . herein we describe a case of scrub typhus presenting as acute right sided heart failure and also discuss the different aspects of cardio - pulmonary manifestations in this rickettsial infection . a 40-year - old female who was previously well - presented to us with complaints of shortness of breath and cough with scanty expectoration for the last 7 days . on examination , she had a heart rate of 132 beats / min , respiratory rate 44 breaths / min , blood pressure 114/82 mm of hg , spo2 of 80% ( on room air ) . systemic examination revealed raised jugular venous pressure ( jvp ) , mild hepatomegaly , and coarse crepitations in bilateral lung bases . chest x - ray revealed bilateral patchy nonhomogenous infiltrates in the mid and lower zones [ figure 1 ] . nt - probnp done in the emergency was > 20,000 pg / ml with normal cardiac enzymes and without any significant electrocardiography ( ecg ) changes . two - dimensional ( 2d ) echocardiography showed normal left atrium / ventricle but enlarged right atrium / ventricle ( ra / rv ) with shifting of interventricular septum towards left and the presence of moderate pulmonary hypertension ( rv systolic pressure = 43 + right atrial pressure ) [ figure 2 ] . computed tomography ( ct ) pulmonary angiography was done which did not show any pulmonary embolism . bilateral pleural effusion was seen along with interlobular septal thickening and ground glass opacities in both lung fields with sparing of periphery of lung fields [ figures 3 and 4 ] chest x - ray of the patient at presentation investigations of the patient two - dimensional echocardiography ( apical view ) showing marked right atrial and ventricular enlargement computed tomography thorax ( mediastinal window ) showing bilateral pleural effusion computed tomography thorax ( lung window ) showing bilateral pulmonary alveolar edema initially , she was treated symptomatically with oxygen , noninvasive ventilation , fluid restriction and diuretics . however , her symptoms worsened , oxygen requirement increased along with a drop in platelets ( 80,000/mm ) . in view of multi - organ involvement and newly developing thrombocytopenia , other possible causes were looked into . immunological workup ( anti - nuclear antibody , anti - double - stranded deoxyribonucleic acid , anti - cyclic citrullinated peptide , and anti - neutrophil cytoplasmic antibody ) were negative . ultrasound guided pleural fluid aspiration was done which revealed exudative effusion [ table 1 ] . weil - felix test was positive and igm antibody for scrub typhus was strongly positive ( by elisa ) . she responded to doxycycline and within 48 h her symptoms decreased significantly and her vitals steadily improved . within another 48 h , her hemoglobin oxygen saturation improved to 95% ( on room air ) and tachypnea and tachycardia resolved and her nt - probnp fell to < 3000 pg / ml . chest x - ray repeated after a week revealed significant improvement [ figure 5 ] and a repeat 2d echo after 2 weeks revealed resolution of ra / rv enlargement [ figure 6 ] . chest x - ray of the patient showing marked improvement after completion of therapy two - dimensional echo of the patient ( apical view ) showing resolution of right heart enlargement after completion of therapy this case presents several unique features . a patient having scrub typhus , presented with features of acute right heart failure ( acute cor - pulmonale ) and ards . ards has been rarely described in cases of scrub typhus but scrub typhus presenting as acute cor - pulmonale has not been described in literature to the best of our knowledge . the fact that the patient was afebrile was another uncommon feature in this case . as the patient was afebrile and did not have eschar mark or history of any insect bite the diagnosis of scrub typhus was not suspected initially and infective conditions were not investigated at the outset . scrub typhus is a rickettsial disease caused by orientia tsutsugamushi which commonly leads to the features of fever , rash , and eschar . in some cases , especially where early treatment is not instituted complications may arise such as meningitis , liver dysfunction , acute kidney injury , and disseminated intravascular coagulation which might lead to multi - organ dysfunction syndrome . heart failure due to scrub typhus patients has been rarely reported where myocarditis has been implicated in the causation of the same . , the full - blown picture of heart failure was manifested by raised jvp , hepatomegaly , raised nt - probnp , and right heart enlargement on echocardiography . the pulmonary edema seen on chest x - ray appeared to be due to ards the occurrence of acute cor - pulmonale in this case was probably due to ards and associated severe pulmonary vaso - constriction induced increased pressure load on the right ventricle . alternatively , the interventricular septum might have been pushed to the left with an increase in the rv pressure and corresponding compromise of the left ventricular output . however , this seems less likely as the pleural effusions in the latter scenario would be expected to be transudative . a right heart catheterization and pressure studies would have been conclusive but could not be done as the patient was severely hypoxemic and required continuous noninvasive ventilator support . thus , this case brings forward some important points . scrub typhus in severe cases can lead to complications involving vital organs such as lungs and heart as was evident in this case . sometimes the classical features of fever , rash , and eschar might all be missing as in our case . however scrub typhus presenting as ards without much fever has been documented by ichimura et al . hence , having a high index of suspicion is important in cases of lung and/or heart involvement especially in endemic areas . in patients with multi - organ failure , the possibility of scrub typhus infection should be borne in mind and investigated if the cause is otherwise not apparent . a systematic review of literature was done to evaluate the nature of involvement of cardiorespiratory system in scrub typhus infection . search was done in pubmed with the following questions with respect to cardiopulmonary involvement in scrub typhus . chest x - ray and ct imaging features different type of diseases caused complications encountered . eschar which is said to be pathognomic of scrub typhus were seen in 43.586.3% patients , cough in 13.738% patients and dyspea in 1849% patients . frequencies of the common symptoms related to the cardio - pulmonary system the x - ray features have been tabulated in table 3 . the incidence of x - ray abnormalities have been described by qu to be around 44% and 59.4% by song et al . among patients with scrub typhus . interstitial pneumonia appears to be the most common radiological feature ( ranging from 40% to 51.4% ) . on ct scan of thorax , the most common features were ground glass opacities and mediastinal lymphadenopathy ( 91% each ) [ table 4 ] while interlobular septal thickening has been noticed in up to 82% patients . the complications related to the cardiopulmonary system have been enumerated in tables 5 and 6 . septic shock has been described in 3 - 65.6% patients and ards in 11.1 - 33.7% patients . frequencies of chest x - ray findings in scrub typhus infection frequencies of computed tomography thorax findings in scrub typhus infection frequencies of cardiac involvement in scrub typhus infection frequencies of different cardiopulmonary complications in scrub typhus infection wang et al . 8 out of 72 ( 11.1% ) patients studied were seen to develop ards and 25% of patients with ards succumbed . initial presentations of dyspnea and cough , white blood cell count , hematocrit , total bilirubin , and delayed use of appropriate antibiotics were independent predictors of ards . settle et al . in their series describing autopsy findings of scrub typhus patients concluded that interstial pneumonia is present in almost all patients with scrub typhus . on chest radiograph abnormalities are present in 5972% patients . zhang et al . noted the involvement of respiratory system in around 25.5% of cases . reticulonodular infiltrates , hilar lymph node enlargement and septal lines are the most common findings while consolidation is relatively uncommon and generally appears in the lower zone of lungs . pleural effusion and unilateral / bilateral hilar enlargement are found in 1243% and 2527% patients respectively . in more than 50% patients abnormal chest radiographs were observed in the 1 week and progressive changes were frequently observed also in the 1 week . fifty - three percent of infected patients have been seen to have relative bradycardia as described by aronoff and watt . scrub typhus increases the risk of acute coronary syndrome by around 37% , and the prominent effect was seen within 1 year of infection . ecg changes have been seen in 14.7% patients and the common changes describe 12 were t wave changes ( 33.3% ) , st - t changes ( 26.7% ) , partial or complete bundle branch block ( 26.7% ) , sinus bradycardia ( 13.3% ) , ventricular extrasystoles ( 6.7% ) , and abnormal q wave ( 6.7%).19 a systematic review of literature was done to evaluate the nature of involvement of cardiorespiratory system in scrub typhus infection . search was done in pubmed with the following questions with respect to cardiopulmonary involvement in scrub typhus . chest x - ray and ct imaging features different type of diseases caused complications encountered . eschar which is said to be pathognomic of scrub typhus were seen in 43.586.3% patients , cough in 13.738% patients and dyspea in 1849% patients . frequencies of the common symptoms related to the cardio - pulmonary system the x - ray features have been tabulated in table 3 . the incidence of x - ray abnormalities have been described by qu to be around 44% and 59.4% by song et al . among patients with scrub typhus . interstitial pneumonia appears to be the most common radiological feature ( ranging from 40% to 51.4% ) . on ct scan of thorax , the most common features were ground glass opacities and mediastinal lymphadenopathy ( 91% each ) [ table 4 ] while interlobular septal thickening has been noticed in up to 82% patients . the complications related to the cardiopulmonary system have been enumerated in tables 5 and 6 . septic shock has been described in 3 - 65.6% patients and ards in 11.1 - 33.7% patients . frequencies of chest x - ray findings in scrub typhus infection frequencies of computed tomography thorax findings in scrub typhus infection frequencies of cardiac involvement in scrub typhus infection frequencies of different cardiopulmonary complications in scrub typhus infection wang et al . 8 out of 72 ( 11.1% ) patients studied were seen to develop ards and 25% of patients with ards succumbed . initial presentations of dyspnea and cough , white blood cell count , hematocrit , total bilirubin , and delayed use of appropriate antibiotics were independent predictors of ards . settle et al . in their series describing autopsy findings of scrub typhus patients concluded that interstial pneumonia is present in almost all patients with scrub typhus . on chest radiograph abnormalities are present in 5972% patients . zhang et al . noted the involvement of respiratory system in around 25.5% of cases . reticulonodular infiltrates , hilar lymph node enlargement and septal lines are the most common findings while consolidation is relatively uncommon and generally appears in the lower zone of lungs . pleural effusion and unilateral / bilateral hilar enlargement are found in 1243% and 2527% patients respectively . in more than 50% patients abnormal chest radiographs were observed in the 1 week and progressive changes were frequently observed also in the 1 week . fifty - three percent of infected patients have been seen to have relative bradycardia as described by aronoff and watt . scrub typhus increases the risk of acute coronary syndrome by around 37% , and the prominent effect was seen within 1 year of infection . ecg changes have been seen in 14.7% patients and the common changes describe 12 were t wave changes ( 33.3% ) , st - t changes ( 26.7% ) , partial or complete bundle branch block ( 26.7% ) , sinus bradycardia ( 13.3% ) , ventricular extrasystoles ( 6.7% ) , and abnormal q wave ( 6.7%).19 cardiopulmonary involvement is not so uncommon in scrub typhus infections and needs to be duly considered when treating such patients .