the action plan of the world health organization ( who ) for prevention and control of non - communicable diseases ( ncds ) in 2013 - 2020 has aimed a 25% relative reduction in the prevalence of hbp . in addition to the effects of fetal programming , several factors determine the blood pressure ( bp ) level in childhood , which is associated with the adult bp level through the  tracking  phenomenon . hence , the prevention of ncds , namely cardiovascular diseases in adulthood should begin from childhood . in addition , hbp in childhood may induce target organ damages , such as left ventricular hypertrophy , thickening of the carotid vessel wall , retinal vascular changes , subtle cognitive changes , and even premature development of atherosclerosis . prevalence of hbp is increasing in the pediatric population in accordance with the childhood obesity epidemic and life - style widespread changes . alarming data exist on the considerable prevalence of childhood overweight and its metabolic consequences , not only in industrialized countries , but also in developing countries . the strong relationship of even early stages of hbp ( pre - hypertension [ htn ] , pre htn ) with obesity and environmental factors , as air pollution , noise pollution and passive smoking suggest that its prevalence will be escalating . in the transitional state communities with rapid urbanization , most risk factors identified for pediatric hbp are modifiable by life - style change , moreover monitoring of their time - trend is of significant importance . ncds have a remarkable prevalence among iranian adults , and the risk factors of ncds are quite prevalent in iranian children and adolescents . high systolic blood pressure ( sbp ) has been recognized responsible for most deaths in all regions of iran . limited experience exists on evaluating ncds risk factors such as hbp in iranian pediatric population at national level . considering the aforementioned importance of pediatric health status and inspired by who recommendations , a national ongoing school based surveillance system for health risk and protective factors named childhood and adolescence surveillance and prevention of adult non - communicable diseases ( caspian ) study was established in iran . the current study aims to determine the bp mean and percentiles , as well as and the prevalence of hbp in a nationally representative sample of iranian children and adolescents . we have previously described the methods of the 4 phase in details , and here we present it in brief . caspian - iv study is a national cross - sectional survey conducted during the year 2011 - 2012 in 30 provinces of iran . the study population comprised of 19 to 18-year old school students equally from both genders . a total sample size of 14,880 was determined to cover all study objectives and then was divided proportionally to population size of urban and rural areas and equally in three educational levels ( elementary , intermediate and high school ) . clusters were the individual schools and it was scheduled to obtain 10 sampling units ( students with their parents ) in each of 48 randomly selected schools for every province . the students questionnaires were based on the who global school - based student health survey ( gshs ) program by adding some questions . these scales are comprehensive and can assess many different aspects of students health as demographic data , diet , physical activity , smoking , violence and other risky behaviors , medical history , family characteristics , relation with parents and peers , etc . , supervision on the whole project was considered by principal investigators at national and sub - national levels . anthropometric measures consisting height , weight , hip , waist and wrist circumferences were measured according to the standard protocols . then , body mass index , waist to hip and waist to height ratios were calculated . bp was measured by expert health care professionals using standardized and calibrated mercury sphygmomanometers in a sitting position from the right arm . with the zero point of manometer at the level of the student 's hearth , appropriate size cuffs were used considering cuff bladders covering 80 - 100% of the arm circumference and approximately two - thirds of the length of the upper arm without overlapping . after enough rest for the subject to calm down , bp readings were taken twice for each person with 5 min interval . the readings at the first korotkoff sound were considered as the sbp and at the fifth sound as the diastolic blood pressure ( dbp ) . pre htn was considered as bp equal or greater than the age- and gender - specific 90 percentile after adjusting for weight and height or bp equal or more than 120/80 mmhg according to the fourth report of the working group ( formerly task force ) on blood pressure control in children , commissioned by the national heart , lung and blood institute of the national institutes of health of america . when bp was equal or over the age- and gender - specific 95 percentile value , it was considered as htn . the study was approved by national and discrete regulatory organizations of the ministry of education and institutional ethical and scientific review boards . clear explanation of the study aims and methods anteceded taking written informed consent from parents and verbal assent from students . the project was completely free of charge for all participants statistical analysis was performed using survey data analysis methods by the stata software : statacorp . mean and standard deviations ( sd ) with 95% confidence intervals ( cis ) were calculated . for nominal or categorical variables , frequencies and prevalence rates with the same ci were recorded . student t - test and chi - square tests were used for comparing that data between relevant groups , where applicable . we have previously described the methods of the 4 phase in details , and here we present it in brief . caspian - iv study is a national cross - sectional survey conducted during the year 2011 - 2012 in 30 provinces of iran . the study population comprised of 19 to 18-year old school students equally from both genders . a total sample size of 14,880 was determined to cover all study objectives and then was divided proportionally to population size of urban and rural areas and equally in three educational levels ( elementary , intermediate and high school ) . clusters were the individual schools and it was scheduled to obtain 10 sampling units ( students with their parents ) in each of 48 randomly selected schools for every province . the students questionnaires were based on the who global school - based student health survey ( gshs ) program by adding some questions . these scales are comprehensive and can assess many different aspects of students health as demographic data , diet , physical activity , smoking , violence and other risky behaviors , medical history , family characteristics , relation with parents and peers , etc . , supervision on the whole project was considered by principal investigators at national and sub - national levels . anthropometric measures consisting height , weight , hip , waist and wrist circumferences were measured according to the standard protocols . then , body mass index , waist to hip and waist to height ratios were calculated . bp was measured by expert health care professionals using standardized and calibrated mercury sphygmomanometers in a sitting position from the right arm . with the zero point of manometer at the level of the student 's hearth , appropriate size cuffs were used considering cuff bladders covering 80 - 100% of the arm circumference and approximately two - thirds of the length of the upper arm without overlapping . after enough rest for the subject to calm down , bp readings were taken twice for each person with 5 min interval . the readings at the first korotkoff sound were considered as the sbp and at the fifth sound as the diastolic blood pressure ( dbp ) . pre htn was considered as bp equal or greater than the age- and gender - specific 90 percentile after adjusting for weight and height or bp equal or more than 120/80 mmhg according to the fourth report of the working group ( formerly task force ) on blood pressure control in children , commissioned by the national heart , lung and blood institute of the national institutes of health of america . when bp was equal or over the age- and gender - specific 95 percentile value , it was considered as htn . the study was approved by national and discrete regulatory organizations of the ministry of education and institutional ethical and scientific review boards . clear explanation of the study aims and methods anteceded taking written informed consent from parents and verbal assent from students . the students questionnaires were based on the who global school - based student health survey ( gshs ) program by adding some questions . these scales are comprehensive and can assess many different aspects of students health as demographic data , diet , physical activity , smoking , violence and other risky behaviors , medical history , family characteristics , relation with parents and peers , etc . , supervision on the whole project was considered by principal investigators at national and sub - national levels . anthropometric measures consisting height , weight , hip , waist and wrist circumferences were measured according to the standard protocols . then , body mass index , waist to hip and waist to height ratios were calculated . bp was measured by expert health care professionals using standardized and calibrated mercury sphygmomanometers in a sitting position from the right arm . with the zero point of manometer at the level of the student 's hearth , appropriate size cuffs were used considering cuff bladders covering 80 - 100% of the arm circumference and approximately two - thirds of the length of the upper arm without overlapping . after enough rest for the subject to calm down , bp readings were taken twice for each person with 5 min interval . the readings at the first korotkoff sound were considered as the sbp and at the fifth sound as the diastolic blood pressure ( dbp ) . pre htn was considered as bp equal or greater than the age- and gender - specific 90 percentile after adjusting for weight and height or bp equal or more than 120/80 mmhg according to the fourth report of the working group ( formerly task force ) on blood pressure control in children , commissioned by the national heart , lung and blood institute of the national institutes of health of america . when bp was equal or over the age- and gender - specific 95 percentile value , it was considered as htn . the study was approved by national and discrete regulatory organizations of the ministry of education and institutional ethical and scientific review boards . clear explanation of the study aims and methods anteceded taking written informed consent from parents and verbal assent from students . statistical analysis was performed using survey data analysis methods by the stata software : statacorp . mean and standard deviations ( sd ) with 95% confidence intervals ( cis ) were calculated . for nominal or categorical variables , frequencies and prevalence rates with the same ci were recorded . student t - test and chi - square tests were used for comparing that data between relevant groups , where applicable . missing data were not included in the analyses . overall , 13486 out of 14880 invited students with a response rate of 90.6% participated in the study . participants consisted of 6640 girls ( 49.2% ) and 6846 boys ( 50.8% ) with one of their parents , 75.6% from urban areas . nearly 46%of them were elementary school , 25.9% intermediate school and 28.1% high school students . mean ( sd ) age of participants was 11.47 ( 3.36 ) years , without significant difference between boys ( 12.36 [ 3.39 ] years ) and girls ( 12.58 [ 3.32 ] years ) . as you can be seen in table 1 , the mean ( sd ) sbp of all participants was 101.52 ( 13.46 ) mmhg and their mean dbp was 64.88 ( 11.41 ) mmhg . blood pressure and anthropometric measures of participants : the caspian - iv study overall , the prevalence rate ( 95% ci ) of pre htn was 3.25% ( 2.79 - 3.8 ) for sbp ( in 13367 measures ) , 1.25% ( 0.98 - 1.6 ) for dbp ( in 13349 measures ) and 3.13% ( 2.71 - 3.62 ) for sbp and/or dbp ( in 13350 measures ) . the corresponding figures for htn were 0.92% ( 0.73 - 1.16 ) , 3.08% ( 2.58 - 3.67 ) and 3.75% ( 3.21 - 4.36 ) , respectively . these together yield a total rate of 4.17% ( 3.84 - 4.52 ) for elevated sbp , 4.33% ( 3.99 - 4.68 ) for elevated dbp and 6.88% ( 6.45 - 7.32 ) for elevated sbp and/or dbp . as shown in table 2 , chi - square test showed that the prevalence rates of pre htn and htn were different in terms of gender and were significantly higher in boys than in girls . prevalence of different categories of blood pressure according to gender : the caspian - iv study the prevalence rates of elevated levels of sbp and sbp and/or dbp were significantly higher in urban than in rural residents too [ table 3 ] . prevalence of different categories of blood pressure according to the living area : the caspian - iv study the current nationwide survey revealed a substantially high prevalence rate for hbp among iranian children and adolescents . by considering the additive prevalence of pre htn and htn , the prevalence rate of high sbp and/or dbp was 6.88% ; and isolated high sbp and dbp were documented in 4.17% and 4.33% of participants , respectively . in the previous phase of this nationwide study , 5.35% of children and adolescents had bp levels equal or more than the 90 percentile values . the increased rate in the current phase of this study may be attributable to unhealthy life - style and nutritional patterns and low physical activity levels in the pediatric age group . other studies about hbp in iranian children and adolescents have been conducted in some cities and no other nationwide study has been performed on pediatric cardio - metabolic risk factors . a series of nationwide studies conducted among iranian adult population , entitled the survey of risk factors of ncds included individuals with 15 - 65 years of age . their results are reported in 10 years age groups , e.g. , 15 - 24 year - old group and according to adults definitions , therefore their results are not comparable with the caspian studies . by considering the cut point 95 percentile to define htn , the prevalence of htn would be expected to be around 5% and in fact 1 - 3% following the recommended three separate measurements in children with an initial bp measurement 95 percentile . for instance , the prevalence of systolic and diastolic hypertension in sousse , tunisia , was reported as 6.4% and 4.5% , respectively . in germany , the prevalence of hbp was 13% according to national standard curves and 2% according to the definition proposed by the international diabetes federation for metabolic syndrome . in portugal , pediatric htn had prevalence of 2 - 5% . in adolescents of texas , united states of america ( usa ) , the prevalence rates of htn and pre htn are reported as 3.2% and 15.7% , respectively . in another study in the usa , a remarkable proportion of youths ( 6.9% ) had htn or nearly met its definition . two other studies in usa reported different prevalence rates , in one of them , 12.7% of youths had pre htn and 5.4% had htn , whereas in another study , these rates were 3.4% and 3.6% , respectively . these differences between studies can be explained by racial , ethnic and genetic issues , different socio - economic states , environmental circumstances , as well as dietary and physical activity habits of participants . in the current study , significant gender difference was documented in the frequency distribution of hbp , with higher prevalence rates of pre htn and htn in boys than in girls . this finding is consistent with a longitudinal study that showed the risk of developing persistent htn is higher in boys than it is for girls . however , in the previous survey of the caspian study , the prevalence of hbp was higher in girls than in boys . another survey did not detect any difference in terms of gender for the prevalence of hbp in the pediatric age group . the gender differences documented in some studies may be explained by various factors as pubertal status , as well as physical activity and dietary patterns . in the current study , elevated sbp and elevated sbp and/or dbp were more prevalent in urban than in rural residents . some studies in other populations have reported conflicting results in this regard . in a study in india , the prevalence rates of pre htn and htn were 2.9% and 2.8% in urban children and 2.8% and 2% in rural children , without statistically significant difference between them . likewise , in another region of india , 5.9% of children had htn and 12.3% had pre htn , with comparable rates of elevated bp in urban and rural areas . contrary to their findings , in ghana , rural children showed lower rates of htn than urban children . in contrast , in a study in children living in the rural area of alabama , usa , the prevalence rates of pre - htn and htn were 6.7% and 14.9% , respectively , which shows much higher rates than our study . lower rates of hbp in rural residents is probably due to a better life - style including healthier dietary and physical activity habits and lower mental stress and pollutants levels in rural than in urban areas . it must be remembered that the definition of hbp in the pediatric population is based on the age- and gender - specific bp percentiles . due to regional differences in the bp percentiles , using various definitions for hbp , different distribution of reference bp data and difficulties in the measurement of bp in children including the necessity of using appropriate cuff size , the findings of different studies may show some variations . overall , the level and pattern of hbp in children and adolescents which we studied needs attention . the prevalence rate of hbp including pre - htn and htn is noteworthy in the pediatric population of iran . it is necessary to use national standards for bp percentiles and design and implement targeted interventions based on research findings for various age groups .