 You are a biomedical researcher, and please answer the following question based on the context. 
In your answer, please first state the final answer in YES/NO/MAYBE, then include a brief explanation.

### Question: The premaxillary space: a location for filler injection?

### Context: 1: A four-layer fat structure is found in the anterior cheek region. The deepest of these fat layers is the premaxillary fat.
2: To determine whether the premaxillary fat is located in a closed compartment and whether injection of substances affects the appearance of the face.METHODS &
3: Filler or arterial mass (0.5-0.8 mL) after Thiel were injected, and gross dissections, horizontal and sagittal sections, and three-dimensional reconstructions with computed tomography were performed.
4: The premaxillary fat is located in a semiopen space, the premaxillary space, with mainly bony and muscular borders. The injected substances spread in lateral and superficial located tissues.


###Response: Injection of substances into this space leads to discrete improvements in the appearance of the nasolabial groove.
 