prostate cancer is a significant cause of death among men in europe and the united states . in the united states , the incidence increased to 24.8 per 100,000 men in 2009 , with a two - fold increase over that in 2008 . however , all available treatments , including prostatectomy , may significantly impact the patient 's quality of life . therefore , clinicians must attempt to determine at the time of diagnosis which patients might do well with active surveillance , who should receive immediate local treatment , and who will require aggressive multimodal therapy . in recent years , several nomograms have been developed to assist clinicians in the prediction of patient outcome following these different treatments . however , most are limited by their complex nature or poor predictive value . in 2005 , cooperberg et al .   derived the cancer of the prostate risk assessment ( capra ) score to preoperatively predict biochemical recurrence - free survival ( rfs ) after radical prostatectomy in patients with localized prostate cancer . its high accuracy was verified through analysis using search data with multicenter enrollment . in the present study , we evaluated the validity of the capra score at a single institution in korea . under institutional review board supervision at inje university busan paik hospital , patients who underwent prostatectomy without adjuvant therapy as the first - line treatment for localized prostate cancer were retrospectively analyzed from january 2008 to june 2013 . a total of 115 patients met all inclusion criteria to calculate the capra score and were included in the study group . the same variable definitions as those in the original capra score design were used in this study . biochemical recurrence after radical prostatectomy was defined as two consecutive prostate - specific antigen ( psa ) values of 0.2 ng / ml at any time postoperatively or any additional treatment more than 6 months after prostatectomy . the patients were divided into two study groups : the seven - group model ( each capra score sum ) and the three - group model ( low , intermediate , and high risk ) . the 3- and 5-year rfs rates were evaluated with kaplan - meier analysis for probabilities . the concordance index for the capra scoring system was calculated with logistic regression and cox regression to determine the predicted survival probabilities . logistic regression analyses were performed , and odds ratios ( ors ) were calculated for the occurrence of positive surgical margins , extracapsular extension , and seminal vesicle invasion . 3.01 ( r foundation for statistical computing , vienna , austria ) were used for the statistical analyses , and p<0.05 was considered statistically significant . the mean age of the patients was 66.4 ( standard deviation [ sd ] , 6.5 ) years . the mean preoperative psa level was 12.7 ( sd , 13.2 ) ng / ml , and 15 patients ( 13% ) developed recurrence at a median of 13 ( sd , 12.1 ) months . the patient characteristics are listed in tables 1 , 2 and are compared with those from the capsure dataset , german data , and japan data . the number of patients with a high preoperative psa level ( > 10 ng / ml ) was similar to that of the german multicenter data ( 41.7% ) . however , the present study showed higher biopsy gleason scores than those in the german multicenter data . these rates decreased as the capra score increased , but the trend was not statistically significant . however , in the three - group model , the 3- and 5-year rfs rates significantly decreased as the risk increased ( p=0.011 ) . for patients with low ( score of 0 - 2 ) , intermediate ( score of 3 - 5 ) , and high risk ( score of 6 - 10 ) , the 3- and 5-year rfs rates were 93.5%/93.5% , 92.2%/85.6% , and 68.1%/61.3% , respectively . the concordance indices of the capra score for the 3- and 5-year rfs rates were 0.74 and 0.77 , respectively . the capra scores of both the three- and seven - group models predicted that the probability of recurrence generally increased with the actual probability of recurrence of the 3- and 5-year rfs . however , in all situations , the capra score tended to underestimate the risk of recurrence ( fig . 2 ) . with the exception of the preoperative serum psa level and clinical t stage , most predictor variables for the capra score ( i.e. , age , gleason sum , and percentage of positive biopsies ) the strongest predictor variable was the gleason sum with a hazard ratio of 11.6 ( p=0.018 ) , and the most reliable variable was the percentage of positive biopsies with a hazard ratio of 5.6 ( p=0.002 ) . we found significantly higher rates of positive surgical margins , extracapsular extension , and seminal vesicle invasion coinciding with higher capra scores or risks in the three - group model ( table 3 ) . positive extracapsular extension occurred in 13.3% of patients with a capra score of 0 to 1 and in 66.7% with a capra score of 7 to 10 ( p=0.003 ) . in the three - group model , positive surgical margins occurred in 16.3% of patients in the low - risk group and in 45.2% in the high - risk group ( p=0.008 ) . these events result not only in an increased incidence of cancer - related morbidities , but also in a heightened level of anxiety for patients and clinicians . therefore , well - established predictors of the risk of disease progression should help clinicians and patients to choose and assess the effectiveness of the various therapeutic options and should especially help with postoperative disease assessment . many nomograms for preoperative risk assessment have recently been introduced . the d'amico risk classification and the kattan nomogram the d'amico risk classification performs well ; however , there is significant overlap between intermediate- and high - risk patients . the kattan nomogram was introduced with better integration of multiple risk factors , but it is difficult to apply without the paper forms of the instruments at hand . however , in low - risk patients in a community setting , the rfs is overestimated . the capra score originated from the capsure database , so it performs well in community - based cohorts , comparable with the kattan nomogram . in a previous study , the c - indices for the three systems were 0.63 ( 0.55 - 0.72 ) for the d'amico classification , 0.65 ( 0.56 - 0.75 ) for the kattan nomogram , and 0.66 ( 0.57 - 0.75 ) for the capra score . in a us multicenter survey using the search database , however , a higher prediction ability for recurrence was obtained in a german multicenter study ( 0.78 and 0.81 ) . in japan , the prediction ability of the 3-year rfs rate is variable among systematic reviews and meta - analyses . furthermore , the capra score is reasonably accurate for predicting metastasis ( c - index=0.78 ) and cancer - specific mortality ( c - index=0.80 ) . the c - index for the 3- and 5-year rfs in the present study was 0.74 and 0.77 , respectively . these rates are higher than those of the original development set and us multicenter survey , but lower than the german multicenter survey and previous systematic reviews . loeb et al .   evaluated the capra score in a single - surgeon radical prostatectomy series , similar to our circumstances ; they calculated a c - index of 0.764 for 5-year rfs , similar to our result . the short follow - up period and the more censored data than in other large - scale studies were probably the reasons for the differences . in addition , the preoperative characteristics of the patients differed from those in other studies . in the present study , the proportion of patients with a high preoperative psa level ( > 10 ng / ml ) was higher than that in the capsure database when the capra score was first introduced ( 41.7% vs. 19% ) , but similar to that in the german data . furthermore , the proportion of patients with a primary gleason score of 4 was higher than that in the capsure and german multicenter data ( 36.5% vs. 9% vs. 14% , respectively ) . generally , lower - risk patients with prostate cancer have been included in us studies . the only significant relationship was seen in the three - group model between the 3- and 5-year rfs and increasing risk ; otherwise , in the seven - group model , the trend of rfs was the same as that in the three - group model , but there was no statistical significance . in both the seven- and three - group models , the capra score predicted probabilities of recurrence that were generally higher than the actual probabilities of recurrence . this is similar to the findings of the german multicenter study . in the german study , the probabilities showed a slight underestimation of the risk of recurrence within the medium - probability range of recurrence and an overestimation of the risk of recurrence within the high - probability range of recurrence . however , our study showed a general underestimation of the risk of recurrence in both the three- and seven - group models for the 3- and 5-year rfs . pathologic outcomes were not available for the development set of the capsure study , but the search study analyzed the prediction ability of the capra score for pathologic outcomes . it showed a statistically significant relationship between pathologic outcomes ( i.e. , positive surgical margin status , extracapsular extension , seminal vesicle involvement , and lymph node involvement ) and an increasing capra score . seminal vesicle involvement was particularly striking , with a near doubling of risk ( or , 1.80 ; 95% confidence interval [ ci ] , 1.6 - 2.02 ) . our results were the same : the capra score showed an increasing probability in terms of the margin status , extracapsular extension , and seminal vesicle invasion . in addition , in the seven - group model analysis , seminal vesicle invasion was the most predictable result with an increasing capra score ( or , 2.35 ; 95% ci , 1.2 - 4.7 ) . only three patients were diagnosed with lymph node invasion as a pathologic outcome in the present study . in the three - group model , the three pathologic outcomes were also significantly related to increasing risk , and seminal vesicle invasion was also the most predictable ( or , 5.62 ; 95% ci , 1.34 - 23.5 ) . this validity of the capra score was also proven by the german multicenter study , and no organ confined with advanced disease was the most predictable ( or , 2.11 ; 95% ci , 1.9 - 2.3 ) . first , few patients were studied compared with other large cohorts ( i.e. , capsure , search ) ; therefore , this study is not representative of all korean prostate cancer patients . however , it is the first study in korea on a new method for predicting prognoses and results after radical prostatectomy . second , because of the short follow - up period , more detailed results regarding rfs could not be obtained . clinicians must decide on treatments after considering the individual traits of patients , such as socioeconomic factors , preferences regarding quality of life , and even genetic factors . thus , it must be understood that the capra score , like other recurrence - prediction instruments , can not replace clinical decision - making in patients with localized prostate cancer . this instrument might help clinicians and patients in planning and counseling at the time of a localized prostate cancer diagnosis , especially when prostatectomy is planned . in addition , characteristics such as convenient use , the scoring system ( seven - group model ) , and the ease of risk stratification ( three - group model ) may support its widespread use . however , additional assessments of its validity are needed in korea , which is experiencing an increasing incidence of prostate cancer , through multi - institutional studies involving large cohorts .