primary hyperparathyroidism ( phpt ) in multiple endocrine neoplasia type i ( men1 ) has a penetrance rate of nearly 100% by the age of 50 years . the underlying pathology in men1 phpt differs from sporadic disease ; parathyroid hyperplasia is present rather than a monoclonal adenoma . differences in the natural history are evident ; patients present at a younger age ( 2025 years ) with early onset of complications for example , affected women have a reduced bone mineral density ( bmd ) by the age of 35 years . effective management of men1 phpt is advisable to reduce complication rates ; a significant reduction in bmd has been observed in men1 patients with uncontrolled phpt compared to those with controlled phpt . surgical cure of men1 phpt is difficult to achieve ; multiple gland hyperplasia , involvement of more than 4 glands and ectopic locations such as the mediastinum dictate the need for thorough preoperative localisation . there remains controversy over the optimal surgical intervention ; total parathyroidectomy necessitates the use of long - term activated vitamin d and the potential complication of hypercalciuria . whilst subtotal parathyroidectomy avoids this , further hyperplasia is likely to occur in residual parathyroid tissue ; recurrence rates of 50% were reported at 812 years post successful subtotal parathyroidectomy . cinacalcet is a potential medical alternative ; by allosterically modulating the calcium sensing receptor on the pth cell , it increases sensitivity to extracellular calcium and down - regulates pth secretion . it is licensed for the management of secondary hyperparathyroidism and parathyroid carcinoma [ 4 , 5 ] . in primary hyperparathyroidism , reductions in serum calcium and to a lesser extent serum pth levels have been demonstrated [ 6 , 7 ] , but the likelihood of surgical cure in sporadic disease usually avoids the need for additional medical intervention . we reviewed the clinical data of nine patients treated with cinacalcet for men-1 phpt with institutional board approval . the cohort consisted of three males , five females , aged 2038 years at diagnosis ( table 1 ) . two patients were unable to undergo surgery ; one due to severe learning difficulties and the second due to an anxiety disorder , and cinacalcet was commenced as primary treatment . pretreatment serum calcium levels ranged 2.622.91  mmol / l , median 2.76  mmol / l ( reference range 2.152.65  mmol / l ) , and pth levels ranged 4.836.5  pmol / l , median 15.9  pmol / l ( reference range 1.36.8  pmol / l ) . all patients deficient in 25-hydroxy vitamin d were commenced on supplements and achieved levels within the laboratory reference range prior to commencement of cinacalcet . six out of eight patients exhibited complications of phpt : reduced bmd in five patients , ( t score of less than 2.5 ) , renal calculi in four patients , and renal dysfunction in four patients ( > 25% reduction in creatinine clearance ) . two patients had no complications of hyperparathyroidism but were under the age of 50 ; all   patients therefore fulfilled criteria for treatment as determined by the consensus on the management of asymptomatic primary hyperparathyroidism 2002 . cinacalcet was generously provided by amgen on a compassionate - use basis to the hospital for no charge . after a product license was obtained in the uk for use in renal failure - related hyperparathyroidism , it was prescribed on an off label basis at 30  mg twice daily . the dose was subsequently reduced in four patients : two due to clinical response and two due to side effects . due to the pharmacokinetics of cinacalcet , all serum calcium and pth measurements were taken predose according to a defined protocol . as steady state drug levels are achieved after 7 days , results of the first clinical assessment ( three months postcommencement ) were used for comparison . the nonparametric wilcoxon signed ranks test was performed for the comparison of the variables between the studied groups because of the small sample size . all patients achieved normocalcaemia on cinacalcet with a median posttreatment serum corrected calcium of 2.35  mmol / l , range of 2.132.54  mmol / l . serum calcium reduced by a median of 0.68  mmol / l , range of 0.100.68  mmol / l , and was statistically significant ( p = .012 ) ( figure 1(a ) ) . serum pth reduced by median of 5.05  pmol / l , range of 0.724.8  pmol / l , ( p = .012 ) ( figure 1(b ) ) . analyses were repeated following removal of a potential outlier ( patient number 8) to confirm statistical significance ; this confirmed a significant reduction in serum pth ( p = .018 ) . a significant increase was noted in serum phosphate ( p = .012 ) but no change was found in 24-hour urinary calcium measurements ( table 2 ) . a comparison was made between pre- and 2 hours post cinacalcet pth measurements for the 5 individuals in whom results were available ; no significant difference was detected ( p = .345 ) . cinacalcet was well tolerated by six patients ; two experienced gastro - intestinal side effects and one subsequently discontinued cinacalcet . duration of treatment was 1035 months with maintenance of biochemical control achieved in seven patients ; the eighth patient defaulted from clinical follow up . incomplete clinical data precluded the statistical comparison of disease end points ; however , no difference was noted in bmd for the five patients reassessed . patients with a history of renal calculi had been successfully treated previously ; none demonstrated recurrent stone formation . our data demonstrate that cinacalcet is effective at significantly lowering serum calcium and pth levels but insufficient data were available to draw conclusions regarding disease end points . control of serum calcium and pth in men1 phpt patients treated with surgery is associated with an increase in bmd   which suggests that aiming for biochemical control is an appropriate therapeutic strategy in these patients . where surgery is not possible or has failed to control men1 phpt existing medical options are limited ; bisphosphonates are effective in improving bone density but have no significant effect on serum corrected calcium or pth levels . recently demonstrated the effectiveness of long acting octreotide in the management of men1 patients with primary hyperparathyroidism and duodeno - pancreatic neuroendocrine tumour . however , long - term adverse metabolic sequelae are likely to outweigh its benefits for primary hyperparathyroidism alone [ 1113 ] . we have demonstrated a more impressive reduction in serum pth ( median 35.5% , range 3.2567.9% ) compared to studies of cinacalcet use in sporadic phpt ( mean reduction 7.6% ) . timing of pth samples in relation to cinacalcet dosing does account for potential variability in results ; a reduction of 37% has been demonstrated at 2 hours postdose , with recovery of predose levels by 8 hours . such pharmacodynamics were not evident in our cohort ; no significant difference was detected between predose and 2-hour postdose pth measurements for the five patients in whom results were available . the reasons for the enhanced pth response seen in our cohort are not clear ; we postulate that the underlying pathology may be of importance . men1 hyperparathyroidism is invariably due to chief cell hyperplasia rather than a monoclonal adenoma . it may be possible that the expression of calcium sensing receptors differs between the two phenotypes and this may influence biochemical response to cinacalcet , although data to support this are currently lacking . previously published data highlighted the theoretical concern of increased urinary calcium excretion with cinacalcet use , due to the direct action at the calcium sensing receptors in the kidney . the overall reduction in serum calcium appears to counteract this effect and significant changes in urinary calcium excretion have not been demonstrated in primary hyperparathyroidism . in view of the theoretical concern , it is the authors ' policy to measure 24-hour urine calcium levels as part of the patient 's annual clinical assessment in addition to regular assessment of serum calcium , phosphate , and pth measurements . effective control of serum calcium and pth levels in men1 phpt is an appropriate therapeutic strategy to reduce the early onset of associated complications . where surgery has been noncurative or is not possible , cinacalcet may provide a medical alternative ; this is supported by our study and a recent case report of a 30-year - old woman who maintained biochemical control after 1 year of cinacalcet for management of men1 hyperparathyroidism . longer - term prospective studies are needed to further evaluate clinical effectiveness , safety , and tolerability .