qt was received as gifted by torrent pharmaceuticals pvt . ltd . , polyox n 10 , polyox n 80 , polyox n 750 and polyox n 205 were gifted by dow chemicals pvt preliminary trials were carried out for selection of appropriate grades of polyox from different grades mentioned above . concentration of polymer and plasticizers were optimized by central composite design . in this design 2 factors the amount of polyox n750 ( x1 ) and peg 400 ( x2 ) were selected as independent variables . the tensile strength , folding endurance , % drug released at 10 min ( y10 ) and disintegration time were selected as dependent variables . preliminary trials were carried out for selection of appropriate grades of polyox from different grades mentioned above . concentration of polymer and plasticizers were optimized by central composite design . in this design 2 factors the amount of polyox n750 ( x1 ) and peg 400 ( x2 ) were selected as independent variables . the tensile strength , folding endurance , % drug released at 10 min ( y10 ) and disintegration time were selected as dependent variables . different grades of polyox were used for film formation like n10 , n80 , n750 and n205 . initially , preliminary trials were carried out to select ideal grade of polymer used for film formation and then used for optimization of other parameters of film . different mentioned grades were tried between 1 - 4% concentrations . from the result , it was observed that by increasing the concentration of polymer up to 2% , thickness and strength of film was improved . but by increasing concentration more than 2% , folding endurance of film was improved but increase in disintegration time more than limit . thus , 2% concentration of polymer was used for further optimization of plasticiser and sweeteners . plasticizer tried were glycerin , peg 400 , and propylene glycol in 15% concentration each . glycerin and propylene glycol showed more sticky film which was unable to detach from surface . polyox n750 was selected for further optimization of film property due to its excellent film forming nature with optimum viscosity for rapid dissolving film . comparison of % elongation of design batches comparison of film thickness of design batches optimization of concentration of polyox n750 and % of peg as plasticisers was optimized systematically using with central composite design ( ccd ) . it was observed that disintegration time of all the batches ranges between 6 - 30 sec , tensile strength between 0.106  0.760 kg / cm , folding endurance between 10 - 89 and drug release profile with in 10 min 80%-99% . all the batches showed more than 80% drug release profile in initial 10 min . from all evaluation parameter , r10 batch with 2% polyox 750 and 15% of peg 400 was considered as promising batch with all satisfactory parameters . for validation of optimum formulation , check point r14 was prepared and evaluated for all the response . observed value was found close to the predicted value , which indicated good correlation of results . optimized film was analyzed by dsc spectra and compared with dsc spectra of pure drug . spectra showed presence of drug peak at same energy of enthalpy as that of pure qt . formulation was stored at 65% relative humidity and 37c temperature in the humidity oven . after 3 months film some predictable changes were observed in film property like decrease in disintegration time and more softness of film due to higher amount of moisture . film texture was evaluated after 3 months of storage which indicates increase in stickiness of film at higher relative humidity . the results of central composite design revealed that the entire factor significantly influences the dependent variable . thus , it can be concluded that by adopting a systematic formulation approaches , an optimum point can be reached in the shortest time with minimum effort . thus , developed film can be useful for curing the emergency condition like schizophrenia which gives rapid relief within short time . stability study data shows need of proper storage condition for film to protect from effect of moisture .