nowadays , the number of individuals with cerebral palsy ( cp ) that survive into adulthood has increased , since life expectancy of children with cp has increased dramatically and their mortality rate has significantly reduced ( 1 ) . consequences of cerebral palsy in adulthood can affect physical , psychological capabilities and quality of life ( qol ) ( 1 ) . one of the most common motor impairments in individual with cp is spasticity ( 2 ) . uncontrolled spasticity affects on joint alignment , activity of daily living and social participation ( 4 ) . studies have shown that adults with cp suffering from degenerative joints diseases , musculoskeletal pain , fatigue , joint deformities and functional mobility deterioration ( 5 , 6 ) . moreover , other problems of adults with cp are job finding , marriage and aging ( 8) . the most commonly applied physiotherapy techniques for cp patients are based on the reduction of impairments and improvement of function however both functional status and quality of life of cp patients are affected ( 9 ) . world health organization quality of life group defines qol as individuals perceptions of their position in life in the context of the culture and value systems in which they live and in relation to their goals , expectations , standards and concerns ( 10 ) . qol scores of adult with cp are significantly lower than healthy people ( 11 ) . studies showed that cp children with better gross motor functioning perceived a higher physical qol ( 12 , 13 ) . ophiem et al reported that physical component correlated negatively with musculoskeletal pain in adults with cp , and there was hardly any correlation between pain and psychological component ( 14 ) . vanderslot et al showed a positive relationship between level of motor function and physical aspect of health related quality of life ( hrqol ) ( 15 ) . furthermore , young et al reported level of motor function was responsible for 45/2% of variance in qol scores in adults with cp ( 16 ) . in contrast , tarsuslu et al and gaskin and morris found no correlation between hrqol and the functioning level in adult population ( 17 ) . therefore results of studies were conducted in adult with cp in the field of association between qol or hrqol and level of motor function are inconsistent . also seldom studies exist that have explored relationship between spasticity and qol in adult cp people . determination of the association between spasticity and the level of motor function with qol could be an evidence for the usefulness of therapeutic interventions . the purpose of the present article was to investigate the relationship between quality of life with spasticity and level of motor function in community dwelling iranian young adults with spastic cerebral palsy . seventy - seven adults with cp were enrolled in this cross - sectional and analytical study . inclusion criteria were diagnosis of spastic cp by a physician , age between 20 and 40 years and lack of any other neurological condition including neuropathies and myopathies . subjects were excluded if they had a history of using inhibitory plasters , fractures , sprain or strain injury of their legs in the past 6 months and scored less than 18 on the folstein mini - mental status test ( mmse ) ( 18 ) . all assessments were completed by a physiotherapist during a single session and were performed in raad rehabilitation goodwill complexes . the ethic committee of the tehran university of medical sciences and health services approved the study . demographic data including age , gender , height , weight , marital status and type of spastic cp ( unilateral and bilateral ) , according to the classification system by of surveillance of cerebral palsy in europe ( scpe)(19 ) and history of taking anti spasticity drug or injection of botolinum toxin type a or any other surgery within the 12 month period were obtained through patients records . to determine the level of motor function or severity of motor impairment the gmfcs is a 5-level classification system which describes motor performance on the basis of functional sitting and walking ability and need for assistive technology and wheeled mobility . individuals in level 1 walk independently while an individual in level 5 has no independent mobility except with significant assistive devices ( 20 ) . in recent years , it has been reported that gmfcs is a reliable and valid tool for classifying gross motor functioning in adults with cp ( 20 ) . mts grades the quality of muscle reaction into 5 levels ( table 1 ) ( 21 ) . to measure spasticity , when the grade of muscle reaction reached two or more , movement was repeated to measure an angle of catch or clonus with hand held gonoiometer ( 21 ) . quality of muscle reaction ( gracies et al 2001 ) . to test spasticity of knee flexor muscles , participants were lied in supine position on a bed , and their hips flexed at 90 and the knees allowed to flex fully under gravity . while one hand of the therapist stabilized the thigh , and the other held under the ankle , so the knee could be moved into the position of maximal extension with a fast  stretching velocity ( as fast as possible ) . when mts score was detected two or more , movement was repeated to obtain an angle of spasticity . in order to apply goniometer , axis was put over the lateral epicondyle of the femur , with stationary arm parallel to long axis femur and movable arm parallel to long axis of tibia . an assistant held lower limb in this angles and the rater measured given angle by goniometer . the affected knee was tested in adults with unilateral involvement while the more affected knee was measured in those with bilateral involvement . the quality of life was measured by the world health organization quality of life questionnaire ( whoqol- bref ) ; it consists of 26 items and envelops four qol dimensions : physical health ( 7 items ) , psychological health ( 6 items ) , social relationships ( 3 items ) , and environmental health ( 8 items ) along with two overall qol and general health items . to score each item within every domain the whoqol - bref has been shown to have a good - to - excellent reliability and an acceptable validity in various groups of participants in iran ( 23 ) . participant filled out the whoqol - bref questionnaire on their own . in this study , spasticity of knee flexor muscles was measured because knee flexor muscles spasticity can greatly interfere with mobility . each participant was given a familiarization trial before the first test session and all assessments were performed randomly . in addition , the relationship between quality of life with spasticity , contracture and level of motor function were assessed using pearson 's product moment correlation coefficient ( r ) and spearman 's rank correlation coefficient . mann - whitney u and independent sample t tests were used to compare mean scores of qol between the two genders . analyses were performed with spss 19 for windows . the kolmogorov - smirnov test was used to test the normal distribution of variables . in addition , the relationship between quality of life with spasticity , contracture and level of motor function were assessed using pearson 's product moment correlation coefficient ( r ) and spearman 's rank correlation coefficient . mann - whitney u and independent sample t tests were used to compare mean scores of qol between the two genders . table 2 presents demographic and clinical characteristics of 77 young adults with spastic cp . in a pilot study on 30 participants , the inter - rater reliability of spasticity angle was very high ( intraclass coefficient ( icc ) value was 0.93 ( p=0.000 ) ) . also , the intra - rater reliability of spasticity angle in 10 participants was investigated in two sessions over one week . demographic and clinical characteristics of 77 young adults with spastic cp sd : standard deviation ; n ( % ) : number ( percent ) gmfcs : gross motor function classification system among the 77 spastic cp participants , 43 ( 56% ) had spasticity in knee flexor muscles . no correlation was found between the severity of knee flexor muscles spasticity with the four domains of qol and the two general items in these 43 individuals ( p > 0.05 ) ( table 3 ) . correlations between the qol and spasticity in 43 individual with spasticity in knee flexor muscles in addition , no correlation existed between qol and the level of motor function ( p > 0.05 ) . table 4 shows value of r and signification of the relationship between qol and spasticity and level of motor function in 77 participants with cerebral palsy . correlations between the qol and level of motor function in 77 individual with cerebral palsy 
 table 5 presents the results of mann - whitney u and independent sample t tests for comparing mean scores of qol 's domains in two genders . comparison of mean scores ( sd ) of the qol domains between two genders ( n=77 ) our results showed that spasticity and level of gross motor function were not correlated with qol . adaptation of our study population to their condition and acceptance of their disability may have resulted due to lack of association between spasticity and qol domains . in contrast , welmer et al reported a low correlation between the physical aspect of hrqol and spasticity in stroke population ( r < 0.4 , p < 0.05 ) . they applied the sf-36 and mas to assess hrqol and spasticity of upper and lower extremities in the people 18 months after first stroke ( 26 ) . therefore , this discrepancy could be related to differences in the measurement tools , type of population and culture . additionally , wiegerink et al reported that young adults with cp had problems in their sexual relationship ( 27 ) . while , our subjects did not report any difficulty in the social aspect , because our participants were single and most of them did not answer the sex item in the qol questionnaire . hence , if all participants answered the sex item of the social domain and we did not have to employ the mean of two other items in this aspect of qol as the score of the sex item , the result of the social domain would have been different . in our study changes in the level of motor function could not alter qol . although the severity of disability is considered as one of the main factors affecting functional status in both children and adults with cp ( 28 ) . it seems that adults perception of qol is discordant with the severity of their disability . furthermore , according to albrecht 's balance theory , the experience of high qol is contingent on the person 's achievement of balance between body , mind and spirit ( 29 ) . we believe that lack of a relationship between qol and the level of motor function could indicate this balance in spastic cp adults . our results are consistent with previous studies which examined the relationship between the level of motor function and qol in cp populations ( 17 , 30 ) . on the contrary , vandersolt et al , reported that bilateral spastic cp adults who had a better gmfcs showed a higher physical hrqol ( 15 ) . the hrqol is a subdomain of qol that focuses on physical health and psychological health . in addition , vargus- adams and ko found that lower gmfcs levels were associated with lower physical health scores ( 12 , 13 ) . this difference could have resulted from different study samples , qol assessment tools and people who completed qol questionnaire . moreover in our study no difference was found between mean scores of qol in females and males . according to the social and cultural condition of iran , disabled people are supported by family and others who are responsible for performing their roles . thus difference between males and females were disappeared . our results were consistent with the findings of van der slot et al and ko et al ( 13 , 15 ) . this study supports lack of relationship between spasticity and level of motor function with qol of community dweller adults with cp . in other word adults who are community dweller , the need for a family and financial support , employment and improve function in order to enhance their qol . future studies should focus on the impacts of other impairments ( such as muscle weakness and impaired balance ) on the qol , to identify which impairment can be affect on qol of adult cp who are community dweller . furthermore , larger studies should be conducted on other age groups and other kinds of cp to determine the relationship between these variables and qol . also , the relationship between spasticity of other muscle groups in upper and lower limbs and qol should be investigated . the cross sectional design , convenience sampling and relatively small sample size may be factors affecting the interpretation of the results . also we can not generalize our results to married adults with spastic cp , people who are imprisoned in the house and other types of cerebral palsy . this study indicated that although spasticity is a common impairment in adult cp patients , it could not change the qol of adults with spastic cp . in addition , it seems that limitations in gross motor function did not affect the qol in adults with spastic cp .