physical dependency is described as  an adaptive state that manifests itself as intense physical disturbance when drug use is suspended  . most people believe that addiction or drug dependency is a male phenomenon and females are less involved in these issues . in the islamic republic of iran , although there is no valid census about drug dependency in iranian women , but the ministry of health reports that there is one female drug dependent per 8 males in iran . the administrators of prisons declare that 50% of female prisoners are in jails regarding drugs and addiction . a study in the united states of america has shown that 7.7% of males in comparison with 5% of females were drug abusers ( the sex difference was lower than 3% ) . in the united states , almost 4.5 million women drink alcohol , 3.5 million abuse prescription drugs , and more than 3 million abused illicit drugs . addiction in women can expose them to malnutrition , high blood pressure , cancer , and some other dangerous diseases like hepatitis or aids . comparing to males , women may be more prone to aids or other sexual transmitted diseases . besides , they are more susceptible to other gynecological diseases and their complications [ 4 , 5 ] . this study was aimed at evaluating extramarital sexual relations in vulnerable women who have substance dependency ( substance dependence in prison ) , invulnerable women of substance dependence ( substance dependence with no history of being in prison ) , and control groups ( women with no history of addiction or being in prison ) in mashhad , a metropolitan in the north east of iran . this cross - sectional study was done on 236 girls and young women aged 1625 years in 2012 , in three groups : vulnerable women who have substance dependency ( crimes that had made women incarcerated were considered as vulnerability in this study ) , invulnerable women who have substance dependency ( substance dependent women without history of incarceration ) , and control group ( women with no history of dependency or being in prison , individuals who had come to health centers for primary health care ) . the sample size was calculated based on the mean difference in two groups based on a previous study , by considering  = 0.05 and  = 0.2 , and 80 persons were calculated for each group . in a first step the calculated sample size for each group was divided into 2 subgroups : 1620 and 2125 years old ( to insure including women younger than 20 ) . in the second step , by using a random sampling method the participants were selected from a list of prisoners ( group 1 ) . at the last step substance dependent women who were referred to welfare centers ( group 2 ) and women who had come to health centers for primary health care ( group 3 ) were selected based on age matching to the first group . all interviewers had attended a training class to eliminate the interinterviewer bias . all participants filled the informed consent and then demographic and familial characteristics , alcohol consumption , and main social and sexual behaviors were obtained . all analyses were done using statistical package for social sciences ( spss ) version 11.5 . demographic and social characteristics of participants are demonstrated in table 1 . as shown in this table , education , occupation status , personal income , family income , lodging , marital status , and alcohol consumption are statistically different in three groups . regarding extramarital sexual relations there was a statistically significant difference between three groups ( 43.8% in vulnerable group , 55.8% in invulnerable group , and 1.4% in control group ; chi = 52.21 , p < 0.001 ) . there was no statistically significant difference between vulnerable and invulnerable groups ( chi = 2.29 , p = 0.15 ) . the extramarital sexual relation based on marital status in all the substance dependent subjects is shown in figure 1 . the kind of sexual relation , safe ( considered as using condoms ) and unsafe ( considered as not using condoms ) , is demonstrated in figure 2 . among 36 extramarital sexual relations in vulnerable women who have substance dependency , 41.7% were unsafe , and among 43 extramarital sexual relations in invulnerable women who have substance dependency 18.6% were unsafe . in the control group , only one person had an extramarital sexual relation and it was safe . there was a statistically significant difference between vulnerable and invulnerable groups ( p = 0.03 ) ( figure 2 ) . as shown in figure 3 , the type of substances which was abused was statistically different in substance dependent participants according to having or not having an extramarital sexual relation ( p = 0.01 ) . alcohol consumption was statistically different in two groups based on safe or unsafe sexual relations ( chi = 9.95 , p = 0.003 ) . 43.8% of vulnerable women who have substance dependency had extramarital sexual relations ; this percentage was 55.8% in invulnerable women who have substance dependency and 1.4% in the control group . teets had described the frequency of rape in female drug abusers and found that , from 60 interviewed women , 73% had a history of rape and 45% had been raped more than once . in 35% of participants raping had been happening when the victims are affected by the substances which were abused . in 2010 , perez del rio et al . studied the relation of drug abuse and showed that in female addicts there is an implicit relation between drug abuse and sexual abuse in childhood or adulthood ( 37.8% ) and in some cases this sexual relation was for earning money ( 51.4% ) . , it was shown that crystal and methamphetamine abuse was higher in addicts who had extramarital sexual relations and alcohol consumption was higher in unsafe sexual intercourse group . although we should notice that crystal and methamphetamine were the most common substances which were abused in all the drug dependent subjects , the type of abused substances was statistically different in two substance dependent women ( p < 0.01 ) . results of this study showed that condom use in sexual relation was not statistically different when the man had abused drugs in comparison with time they had not used illicit drugs ( 48.3% versus 49% ) . the differences between the results of that study and our study may be due to gender difference . in one study in tanzania , fisher et al . studied safe and unsafe sexual relations in subjects who had drunk alcohol 2 hours before the intercourse comparing to the ones who had not . results showed that condom usage failure ( in males , females , or both ) was more than 5 times higher in individuals who had drunk alcohol before the sexual relation especially when the woman had drunk alcohol . alcohol consumption was higher in some situations : the first sexual relation in women , sexual relations in unknown or with less control era , and people whose parents had abused drugs or alcohol before sexual relations . surprisingly , condom usage was not related to alcohol consumption but the probability of failure was much higher . in this study we did not assess the condom use failure , so if we did it , the result could be the same , but condom usage was related to alcohol consumption and this difference may be because of different cultural contexts and sexual behaviors in societies . in this study the extramarital relation was higher in drug dependent women . results showed that out of 27 addict women , 14 had a history of extramarital sexual relation . dependent women had a lower educational level but relatively had high personal income and being married was a protective factor for extramarital relation . in another study in texas , it was demonstrated that addict women had lower education and income than addict men . the higher rate of extramarital relation in single females was the same as the result of this study . the results of another study showed that nearly 25.5% of subjects had high risk sexual behaviors in which 47% had not used condoms in the last sexual intercourse . high risk sexual behaviors were higher in heroin addicts , lower ages , and higher income groups . in this study the extramarital relation was higher in higher personal income but this study is a cross - sectional study and we can not conclude causality from this type of study . one reason may be that this group has an extramarital sexual relation to earn money . 
 motazakker et al . studied the high risk behaviors in 384 addicts who were receiving methadone as a treatment . intravenous method of drug abuse was used by 58 subjects ( 15.1% ) , snuff in 235 subjects ( 61.4% ) , and oral method in 91 subjects ( 23.6% ) . 102 subjects ( 26.6% ) had a history of alcohol consumption for more than 5 years , 88 subjects ( 22.9% ) had tattoos , 6 subjects ( 1.6% ) had needle sharing , 19 subjects ( 5% ) had razor blade sharing , and 62 subjects ( 16.1% ) had a history of extramarital sexual relation . the pattern of drug abuse was as follows : heroin in 127 ( 33.1% ) , opium in 194 ( 50.5% ) , crystal in 2 ( 0.5% ) , crack in 26 ( 6.8% ) , and cannabis in 2 ( 0.5% ) individuals . the result of this study emphasizes the role of drug dependency in sexual behaviors . in this study there was a statistically significant difference in extramarital sexual relation based on marital status and being married seems to be a protective factor from extramarital sexual relation . based on our study results and some other similar studies [ 1518 ] we can conclude that higher rates of extramarital sexual relations and unsafe sexual intercourse can be the consequence of drug dependency in women . poverty , the need for money to buy drugs , high rates of divorce in addict women , the need for higher doses to increase sexual arousal , and finally psychological problems with sexual self - esteem form a vicious cycle that can harm this group even more . addiction , poverty , and family breakdown are among the most important social determinants of health that need more attention , especially in this specific group  substance dependent women .