a 28-year - old female born out of a second - degree consanguineous marriage presented with a gradual onset of decrease in vision in both eyes for 5 years . the patient was alright till the age of 10 years , when she developed skin changes , failure to gain weight , and had oligomenorrhea and irregular menses . she was on treatment for diabetes mellitus , high lipid profile and hypothyroidism , which developed as a consequence of radiotherapy for thyroid enlargement . , she had a short stature ( 134 cm ) , weighed 25 kg , looked emaciated , had gray , sparse scalp hair , bird - like facies , hoarse voice , thinned , hyperpigmented skin and lean arms and legs [ fig . ( a ) external photograph of a 28-year - old patient with ws with bilateral cataracts , emaciated look , gray sparse scalp hair , a bird - like facies , thin hyperpigmented skin ; ( b ) external photograph showing short stature and lean arms and legs on ophthalmic examination , best corrected visual acuity was 20/60 , n12 in the right eye ( re ) and counting fingers 6 ft , n36 in the left eye ( le ) . slit - lamp examination showed nuclear sclerosis grade 2 in the re and total cataract in the le . she underwent a clear corneal phacoemulsification with hydrophilic foldable intraocular lens ( iol ) implantation in the le under peribulbar anesthesia . intraoperatively , a thick posterior capsular calcified plaque was noticed which could not be removed by peeling with a 26 g needle . primary posterior capsulotomy ( ppc ) was avoided for the fear of inducing cystoid macular edema ( cme ) . after iol implantation , the corneal tunnel and side ports were closed with 10/0 nylon suture . postoperatively , the patient was started on ketorolac tromethamine ophthalmic solution 0.4% four times daily and gatifloxacin eye drops 0.3% four times daily . the patient was started on a weak steroid ( fluorometholone eye drops ) twice daily for a week on the 4th postoperative day because of the increased anterior chamber reaction . on subsequent visits , the eye was quiet . at 1 month , the best corrected visual acuity was 20/40 n12 . she was operated in the re 6 months after the first cataract surgery with similar precautions . yag capsulotomy was done 4 months from the date of surgery in le [ fig . ( a ) slit - lamp photograph of the le showing pseudophakia with posterior capsular plaque ; ( b ) slit - lamp photograph of the le showing pseudophakia after yag laser capsulotomy preoperative , postoperative and post yag capsulotomy endothelial cell counts about 1300 cases have been reported around the world from 1916 to 2002 , including about 1000 japanese patients . the international registry of ws ( www.wernersyndrome.org ) uses the above findings [ table 2 ] to establish a  definite ,   probable ,  or a definitive diagnosis requires all the cardinal signs and two signs from  other signs  . our patient had all the cardinal signs and two others ( diabetes mellitus , hoarse voice ) , thus satisfying the criteria for a definitive diagnosis . showing clinical features of ws cataract is one of the typical ocular manifestations of ws . corneal decompensation occurred in 8 of the 18 eyes of patients with ws after cataract surgery when surgery was done by intracapsular or conventional extracapsular surgery . decreased endothelial function in ws is due to prematurely aged cornea the more recent studies in which cataract surgery was done by phacoemulsification show that it can be done safely without an increased rate of complications . in this patient , cataract surgery was done by phacoemulsification with the following precautions : ( 1 ) small incision size of 2.8 mm ; ( 2 ) liberal use of sodium hyaluronate 1.4% to protect the corneal endothelium ; ( 3 ) closure of the corneal tunnel and side ports using 10/0 nylon suture to prevent wound dehiscence ( impaired wound healing is a feature of ws ) ; ( 4 ) weak steroids were used postoperatively so as not to suppress fibroblast proliferation . decreased fibroblast proliferation rate has been proved by cell culture in ws and could be the cause for impaired wound healing . endothelial count in le , 4 months post surgery , showed a 7% ( 141 cells / mm ) reduction and , in re , 2 months post surgery , showed a 5% ( 110 cells / mm ) reduction which falls within the normal range . studies report endothelial cell loss rates from 4% to 15% after phacoemulsification by experienced surgeons . ppc was avoided as the incidence of cme after ppc was higher than without it . a study carried out by allan r. slomovic gives a cell loss of 2.3% after yag capsulotomy . in our patient , the cell count showed a 0.48% ( 9 cells / mm ) reduction , 4 months after yag capsulotomy . there was no change in the morphology of the cells . in case of ws with an already compromised cornea , we expected the cell loss to be more than the expected . the last follow - up 15 months postoperatively in the le and 9 months postoperatively in the re showed an 8.6% ( 174 cells / mm ) decrease in cells in le and 7.3% ( 160 cells / mm ) decrease in re , which is within the normal range of cell loss . we conclude that short - term results after cataract surgery and yag capsulotomy were excellent with modern microsurgical techniques in a patient with ws . through this case , we want to highlight that ws should be kept in mind when operating on any patient with features of premature aging and special precautions should be taken when doing the cataract surgery .