dna origami robots were designed using cadnano 2.0 ( http://cadnano.org ) , and folded using m13mp18 ssdna as scaffold strand in tae buffer containing 10 mm magnesium . robots were imaged using tem and afm , and their states were measured using flow cytometry . adult blaberus discoidalis were maintained at constant room temperature in humid plastic cages with dry pet food and fresh fruit ad libitum . robots ( typically 0.1 - 3 pmol in 10 ul buffer ) were injected into the animal hemocoel between the two last abdominal sternites . hemolymph was extracted through the arthrodial membrane and mixed with anticoagulant buffer before hemocytes analysis . for detailed methods