since ancient times , electrical stimulation has been used to modulate the nervous system and to treat some neurological disorders ( rossi , 2003 ) . scribonius largo , physician of the roman emperor claudius , in his text  compositiones medicamentorum ( 46 ad ) suggested the application of electric ray ( torpedo torpedo and torpedo nobiliana ) on the cranial surface as a remedy for the headache . these fishes are known for being capable of producing an electric discharge and their scientific name comes from the latin torpere ,  to be stiffened or paralyzed ( but also to be numb , insensitive ) , referring to the effect on someone who handles them ( debru , 2006 ) . electric fishes were later used for the treatment of seizures , depression , and pain until the eighteenth century ( kellaway , 1946 ; schwalb and hamani , 2008 ) . in the early ninetieth century giovanni aldini ( 17621834 ) , nephew of the discoverer of animal electricity luigi galvani ( 17271798 ) and professor of physics at the university of bologna , performed electrical stimulations on the exposed human cerebral cortex of recently decapitated prisoners . in 1804 , aldini reported that cortical stimulation evoked horrible facial grimaces . this finding led him to conclude that the cortical surface could be electrically stimulated ; supporting that electricity could have therapeutic effects in the treatment of many neuropsychiatric disorders ( aldini , 1804 ; boling et al . aldini s experimentations and hypotheses led to direct research into two strands that would later developed during the ninetieth and twentieth century : on the one hand the use of brain stimulation for neurophysiologic investigation ( initially on animals and then on humans ) to understand the functioning of the brain , on the other hand the use of the techniques of brain stimulation for therapeutic purposes . concerning neurophysiologic research , in 1809 luigi rolando ( 17731831 ) first used galvanic current to stimulate the cortical cortex of animals ( rolando , 1809 ) , highlighting the functions of brain areas , while in 1870 gustav fritsch ( 18381927 ) and eduard hitzing ( 18381907 ) showed that electrical stimulation of specific cortical areas evoked muscle contractions in dogs ( fritsch and hitzing , 1870 ) . in 1872 david ferrier ( 18431924 ) identified monkey s cerebral cortex points whose stimulation was related to specific movements of the animal ( ferrier , 1873 ; gross , 2007 ) . in 1874 the american physician robert bartholow ( 18311904 ) was the first to report findings from studies of electrical stimulation of the cerebral cortex in an awake human ( bartholow , 1874 ) . in 1882 the italian neuropsychiatrist ezio sciamanna ( 18501905 ) performed a series of systematic experiments of electrical stimulation on a trepanned patient who had a traumatic brain injury ( sciamanna , 1882 ; zago et al . , 2008 ) . in 1883 the italo - argentine surgeon alberto alberti ( 18561913 ) conducted an experiment lasting more than 8  months of cerebral stimulation in a woman in whom an eroding tumor of the skull allowed easy access to the dura mater surface , like in bartholow s case ( alberti , 1886 ) . unfortunately , the contribution of these researches in determining the motor topography of the human brain nonetheless remained poorly exploited except to confirm the electrical excitability of the cortex and demonstrate the contralateral cortical hemispheric representation of motor functions ( zago et al . , more precise and systematic observations on the topography of the brain had been made in 1887 by the british surgeon victor horsley ( 18571916 ) ( vilensky and gilman , 2002 ) , but we should wait for until 1950  when fundamental studies of the neurosurgeon wilder penfield ( 18911976 ) were published  before the brain stimulation of the human cortex could give a real accurate representation of the human brain functions , including motor and somatosensory areas ( cortical homunculus ; penfield and boldrey , 1937 ; penfield and rasmussen , 1950 ) . electroshock , introduced by ugo cerletti ( 18771963 ) in 1938 was the first modern example of therapeutic application of brain stimulation for the treatment of severe psychosis ( cerletti , 1940 ; kalinowsky , 1986 ) . the application of an electric current on the skull evoked an epileptic seizure that  roughly  remodeled the neural connections , providing a clinical improvement to the patients . despite opposing opinions about this technique , this method had a more solid foundation rather than the dubious experiments of electrical brain stimulation for the treatment of schizophrenia and other mental illness conducted at tulane university in the 1960s ( baumeister , 2000 ) . brain stimulation for pain control , used as early as 1950 with good effects through temporary electrodes implanted into brain regions , after a first experimental phase , found its explanation in the  gate control theory  developed by melzach and wall in 1962 ( rezai and lozano , 2002 ) . these previous studies were the basis that led to the development of new techniques of neurostimulation : transcranial magnetic stimulation , cortical brain stimulation , and deep brain stimulation ( dbs ) . transcranial magnetic stimulation produces a magnetic field to modulate the excitability of the brain cortex . unlike electroshock , it can stimulate only a specific area ( selectivity ) through an eight - shaped magnet and it does not involve loss of memory and/or seizures . it is mainly used for the treatment of psychiatric diseases , as obsessive  compulsive disorder and depression , and recently in one case of minimally conscious state ( wassermann et al . , 2008 ; piccione et al . , cortical brain stimulation involves the application of chronic low - frequency electrical pulses on the motor cortex through intra- or extra - dural implantation of one or more electrodes connected to a generator with a battery located in the chest . it is particularly used for the treatment of some forms of parkinson s disease , epilepsy , and dyskinesia , but also for the pain control and in patients afflicted with stroke ( pagni et al . deep brain stimulation is a surgical procedure that allows implanting microelectrodes precisely in some brain areas through a combination of stereotactic and neuroimaging techniques . deep brain stimulation is an evolution of functional stereotactic neurosurgery techniques , initially used to produce selective lesions of specific deep brain structures ( thalamic and cerebellar nuclei ) . thus , a new balance of damaged neural circuits could be found , removing the tremor in patients suffered from medically refractory parkinson s disease and motor disorders of dyskinesias . in 1947 ernst spiegel and henry wycis , modifying the original apparatus of clarke and horsley ( 1906 ) , produced the first human stereotactic frame that using pneumoencephalogram allowed to determine cartesian coordinates of structures around ventricles ( basal ganglia ) for identifying the precise localization of the targets that had to be destroyed by radiofrequency ( spiegel et al . intra - operative electrical stimulation of these structures was systematically used for the exploration and the localization of the deep cerebral nuclei and for confirming target ( guiot et al . these observations led to suggest that these stimulations of deep cerebral nuclei could be used not only as a method for diagnostic purposes but also as a therapeutic method itself . thus , the evolution from lesional to stimulating functional neurosurgery was determined ( porta and sironi , 2009 ) . the origins of this technique are linked to the discovery of the effects of electrical stimulation of the deep brain areas , conducted during the stereotactic lesional functional neurosurgery to identify the correct position of coagulant electrodes for the treatment of dyskinetic disorders and tremor in parkinson s disease ( schwalb and hamani , 2008 ) . thanks to the spread of stereotactic method , various studies demonstrated that , while  low - frequency stimulation  ( 510  hz ) could enhance tremor and other correlated symptoms ,  high - frequency stimulation  ( 50100  hz ) resulted in a reduction of symptoms ( albe fessard et al . , 1963 ; blomstedt and hariz , 2010 ) . ( 1952 ) , bekthereva et al . ( 1963 ) , sem - jacobsen ( 1965 ) , and cooper ( 1978 ) . deep electrical stimulation of brain structures was originally introduced as a therapeutic option to treat behavioral disorders or chronic pain . in 1952 , the spanish neuroscientist jos m. delgado , basing on his experience of deep neurophysiologic electrical stimulation in animals , first described the technique of implantation of intracranial electrodes in humans , indicating the importance of this method for diagnosis and its possible therapeutic role in patients with mental disorders ( delgado et al . , 1952 ) . over the next two decades , he implanted radio - equipped electrode arrays that he called  stimoceivers ,  in cats , monkeys , chimpanzees , gibbons , bulls , and even humans , and he showed that he could control subjects mind and bodies with the push of a button . his experiments on animals were often very  theatrical .  for example , in 1963 he demonstrated the possibility to stop a bull from charging in response to a radio - signal of one electrode implanted in the brain of animal . however , the critics contended that the stimulation did not quell the bull s aggressive instinct , as delgado suggested , but rather forced it to turn to the left ( horgan , 2005 ) . at that time , he implanted electrodes in 25 human subjects , most of them schizophrenics and epileptics . in 1969 he described his brain stimulation researches and discussed critical aspects and ethic implications in the book physical control of the mind : toward a psychocivilized society , where he showed the tremendous opportunities but also the great risks derived from neurotechnology ( delgado , 1969 ) . the first to use chronic depth stimulation as a therapy in motor disorders was natalia petrovna bekthereva , neuroscientist at the institute of experimental medicine and the academy of medical sciences in leningrad . in 1963 she published a work on the use of multiple electrodes implanted in sub - cortical structures for the treatment of hyperkinetic disorders ( bekthereva et al . , 1963 ) . however , since her papers were written in russian , her works were not well known around the world . in her  therapeutic electro - stimulation ,  as she named this method , she used  electric stimulation with high - rate pulses of suprathreshold current ,  achieving excellent results ( bekthereva et al . , 1975 ) . the norwegian neurophysiologist and psychiatrist carl wilhelm sem - jacobsen initially used depth electrodes implanted for recording and stimulation in patients with epilepsy and psychiatric disorders . he successfully implanted multiple electrodes in the thalamus to stimulate the targets in order to identify the best lesional site in parkinson s disease . these electrodes were often left into the patient s brain for several months , without any side effects . as he wrote : these electrodes could then be used , following stimulation responses , to make incremental staged lesions in the target area ( sem - jacobsen , 1965 , 1966 ; blomstedt and hariz , 2010 ) . by the early 1970s , there were some reports of chronic dbs system implanted in the thalamus for the treatment of chronic pain ( hosobuchi et al . , 1973 ; mazars et al . , 1974 ) , and isolated experiences in the patients with persistent vegetative state ( hasserl et al . , 1969 the experience of the american neurosurgeon irving s. cooper in placing electrodes over the cerebellum and into the deep thalamic nuclei for central palsy , spasticity and epilepsy was more extensive and continuous . in 1977 he reported its excellent results from chronic cerebellar stimulation in over 200 patients ( cooper , 1978 ) . the lack of correlation of opinion of efficacy between the patients and clinicians led cooper and other scientists to perform double - blind studies on cerebellar stimulation for spasticity . the results of these studies did not try to show a real efficacy of this procedure ( schwalb and hamani , 2008 ) . after the introduction of l - dopa in the late 1960s , there was a sharp decline of the surgical treatment of parkinson s diseases and the ablative procedures continued , only targeting ventral intermediate nucleus ( vim ) and globus pallidus . dbs progressed as a technique through its use in psychiatric and pain control surgery . despite the sharp decline of surgery for parkinson s disease given the use of l - dopa , many groups continued to perform thalamotomy for tremor of various etiologies ( schwalb and lozano , 2004 ) . the positive effect of thalamic stimulation on tremor was well known ( due to the diagnostic neurostimulation maneuver done prior to coagulation to be sure of being in the right target ) , but the idea to use chronic stimulation as a therapeutic method did not emerge until benabid s preliminary report in 1987 on stimulation of the vim nucleus ( benabid et al . , 1987 ) . in 1991 , both benabid and blond and sigfried groups reported their results on thalamic dbss for tremor ( benabid et al . subsequent studies found that the dbs of thalamus was safer than thalamotomy and especially bilateral thalamotomy . likewise , the stimulation of globus pallidus was demonstrated safer than pallidotomy , originally proposed by laitinen for medically refractory parkinson s disease in the early 1990s ( laitinen et al . , 1992 ) . the major safety of the dbs of these areas led a gradual abandonment of lesional techniques . in 1994 pollak s group began to stimulate a new target , involved in parkinson s disease : the sub - thalamic nucleus of luys ( stn ; pollak et al . , in particular , the dbs of this area has been found to be effective for bradykinesia , tremor , and rigidity . moreover , the stimulation of snt and globus pallidus was explored for the treatment of both generalized and segmental dystonia ( yu and neimat , 2008 ) . in addition to movement disorders , dbs was also mostly used and explored for treatment of chronic pain , subsequently approved by us food and drug administration in 1989 . concerning the future of dbs for movement disorders , although multiple studies demonstrated its efficacy , many questions still require answers . in deed , as above reported , dbs has been showed to be effective in patients with medically refractory parkinson s disease in both motor function and quality of life , but it is unclear what the effect of these techniques are on non - motor aspects of this pathology . furthermore , we should exactly know when a patient could be considered as drug unresponsive and whether a early dbs could slow the progression of the disease . concerning dystonia , a rigorous trial was conducted on the efficacy of dbs of globus pallidus for primary dystonia , but the report of dbs for secondary dystonia consists of small case series . on contrary , the efficacy of stimulation of snt is still clearly defined for this disorder ( holloway et al . , 2006 ; benabid , 2007 ; schwalb and hamani , 2008 ) . bds in the treatment of refractory epilepsy has gotten the attention from epileptologists due to its well - documented success in treating movement disorders . early results of the sante trial should lay the foundation for widespread implementation of dbs for epilepsy targeting the anterior thalamic nucleus . other hopeful target seems to be the caudate nucleus , the sub - thalamic nucleus , the cerebellum , the centro - median nucleus of the thalamus , and the hippocampus , even if the results are non - conclusive ( halpner et al . recently , the indication of the use of dbs has been extended to new diseases , so new interesting perspectives for future therapies seem to be opened . bilateral thalamic stimulation has been used for the treatment of refractory tourette syndrome , a complex pathology characterized by multiple motor tics and one or more phonic / vocal tics lasting longer than 1  year . the first results are positives with improved clinical features ( porta et al . , 2010 ) . dbs has been also indicated for the treatment of serious psychiatric disorders , such as refractory depression and obsessive  compulsive disorder . in addition to psychiatric diseases , dbs has also been suggested as a potential therapy for obesity , eating disorders , and drug resistant hypertension ( mayberg et al . , 2005 ; although dbs for pain has been largely abandoned , the group of milan has explored dbs of the posterior hypothalamus for cluster headache ( franzini et al . , 2003 ; moreover , a recent study has re - explored dbs for the minimally consciousness state after severe traumatic brain injury ( schiff et al . , 2007 ) . since the introduction of dbs , almost 20  years ago , there has been an immense resurgence of interest in the neurosurgical technique for the treatment of more neurological and psychiatric disorders . the reversible nature of stimulation technique is an attractive feature and clinical conditions that were not believed to be surgically tractable are now being considered suitable for dbs therapy . the success of dbs in the treatment of refractory parkinson disease is evident , while for the other motor disorders ( primary tremor , dyskinesias , medically refractory tourette s syndrome ) good results are waited . the major psychiatric diseases ( refractory depression , obsessive  compulsive disorder ) , cluster headache , epilepsy , eating disorders ( obesity ) , and drug resistant hypertension are the new field where the dbs seems to have interesting therapeutic possibilities . what other neurological and psychic disorders can dbs be applied to ? what should be the criteria for selecting candidates ? only when they are or are considered as ? for some diseases should dbs be used regardless of pharmacological therapy ? could an early use of dbs change the natural history of some kinds of disease ? in addition , an objective and statistically valid assessment of long - term results and of possible technique - related complications is still central . , it is fundamental to the involvement of family members , in addition to their direct involvement with the informed consent . the procedure must be supported by interdisciplinary teams of neurosurgeons , neuroscientists , psychiatrist , psychologist , and other health professionals who can help assess patients suitability for dbs and continuously monitoring them over time . the dbs is not a modern form of psychosurgery and for this reason  technical and ethical  mistakes , that historically characterized this terrible chapter of history of neuroscience , should be avoided ( kringelbach and aziz , 2010 ) . while psychosurgery was a lesional unselective and irreversible manipulation of a brain area ( e.g. , the lobotomy proposed by egas moniz since 1935 and its subsequent variants ) , the primary goal of dbs is to rebalance the damaged neuronal circuits through a electrical selective and reversible manipulation ( stimulation ) of targeted brain structures , whose alteration may determine , along with neurological deficits , also behavioral problems ( e.g. , tourette s syndrome ) . concerning the  psychiatric  indications ( refractory depression and obsessive  compulsive disorder ) , the evidences of organic alterations underlying these events provide an adequate explanation for the fact that the rebalancing of specific neurophysiologic substrates through the dbs can improve these behavioral disorders , harmonizing the physical and psychological expressions of these subjects . the author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest .