experimental details of the synthesis and characterisation , in vitro assays and cell - based studies , as well as supplementary figures , are given in the supporting information available via http://dx.doi.org/10.1002/cmdc.201300428 . as a service to our authors and readers , this journal provides supporting information supplied by the authors . such materials are peer reviewed and may be re - organized for online delivery , but are not copy - edited or typeset . technical support issues arising from supporting information ( other than missing files ) should be addressed to the authors