the human body has simple and compound organs that obtain their nourishment through four humors . one of them is bile ( yellow bile ) . according to iranian traditional medicine ( itm ) , there are various kinds of natural medicines with their specific mechanisms of action affecting on bile in the human body . hakim aghili shirazi ( 18th century ) , one of the great scholars in itm field , introduced all types of natural medicines influencing bile in his valuable book written in persian ,  makhzan - ul - adwiah  , about single herbal medicines ( mofradat ) . the aim of this review article was to introduce all types of natural medicines influencing bile in the human body . the classification of natural medicines influencing bile was studied in this article as viewed by hakim aghili shirazi in makhzan - ul - adwiah . reviewing makhzan - ul - adwiah , this natural influencing bile is defined in ten categories . these are haabes - e safra ( obstructive of bile ) , daafe - e safra ( expellant of bile ) , raafe - e safra ( resolver of bile ) , ghaate - e safra ( stopper of bile ) , ghaame - e safra ( suppressant of bile ) , kaasere - e safra ( fractionating of bile ) , mohregh - e safra ( burner of bile ) , moder - e safra ( bile diuretic ) , mosaken - e safra ( bile reliever ) , and moshel - e safra ( bile laxative ) . recognition of the precise mechanisms of these natural medicines is necessary to prescribe a suitable remedy for bilious diseases by traditional medicine specialists .