distance between two genes was defined as the number of base pairs between their gene midpoints . relative distance refers to the distance of a tsg or a noncancer gene from an oncogene divided by the radius distance . the gene labels were randomly shuffled 10,000 times to generate new positions of oncogenes , tsgs and noncancer genes for the calculation of p - value . gene density is the number of tsgs or noncancer genes in a radius of specified distance divided by the radius distance . average density is the total number of all tsgs or noncancer genes on a particular chromosome divided by the length of that chromosome . a tumor types with cna profiles obtained by whole - genome sequencing were included in the present study . level 3 distance between two genes was defined as the number of base pairs between their gene midpoints . relative distance refers to the distance of a tsg or a noncancer gene from an oncogene divided by the radius distance . the gene labels were randomly shuffled 10,000 times to generate new positions of oncogenes , tsgs and noncancer genes for the calculation of p - value . gene density is the number of tsgs or noncancer genes in a radius of specified distance divided by the radius distance . average density is the total number of all tsgs or noncancer genes on a particular chromosome divided by the length of that chromosome . a tumor types with cna profiles obtained by whole - genome sequencing were included in the present study .