preparation of solid dispersion of domperidone : domperidone inclusion complexes were prepared with -cd in different ratio ( 1:1 , 1:2 and 1:3 ) by kneading method . preparation of fast dissolving films : solid dispersion of domperidone and -cyclodextrin ( 1:3 ) was selected and dispersed in half quantity of water and to it methanol is added along with tween-80 and heated at 60c . in other half quantity of water , hpmc e15 it is dried in oven at 60c for 5 hrs to obtain the film . morphological properties : properties such as homogeneity , color , transparency and surface of the oral films were evaluated by visual inspection.film mass : the mass of three films were determined by an analytical balance and means.d was calculated.film thickness : film thicknesses were measured at five positions ( central and the four corners ) using the digital vernier caliper and the mean thickness was calculated.folding endurance study : it was measured manually by repeatedly folding a film at the same place till it broke.in vitro disintegration studies : the film as per the dimensions ( 3  2 cm ) required for dose delivery was placed on a stainless steel wire mesh placed in a petridish containing 10 ml phosphate buffer ph 6.8 . time required for the film to break was noted as in vitro disintegration time.dissolution and drug release : dissolution test of films was performed using ( 900 ml ; phosphate buffer ph 6.8 with usp dissolution apparatus ii at 50 rpm and 370.5c temperature . the drug release was analyzed spectrophotometrically at max 286.5 nm using ultraviolet ( uv ) spectrophotometer ( shimadzu model no : 1800 ) . morphological properties : properties such as homogeneity , color , transparency and surface of the oral films were evaluated by visual inspection . film mass : the mass of three films were determined by an analytical balance and means.d was calculated . film thickness : film thicknesses were measured at five positions ( central and the four corners ) using the digital vernier caliper and the mean thickness was calculated . folding endurance study : it was measured manually by repeatedly folding a film at the same place till it broke . in vitro disintegration studies : the film as per the dimensions ( 3  2 cm ) required for dose delivery was placed on a stainless steel wire mesh placed in a petridish containing 10 ml phosphate buffer ph 6.8 . dissolution and drug release : dissolution test of films was performed using ( 900 ml ; phosphate buffer ph 6.8 with usp dissolution apparatus ii at 50 rpm and 370.5c temperature . the drug release was analyzed spectrophotometrically at max 286.5 nm using ultraviolet ( uv ) spectrophotometer ( shimadzu model no : 1800 ) . morphological properties : properties such as homogeneity , color , transparency and surface of the oral films were evaluated by visual inspection.film mass : the mass of three films were determined by an analytical balance and means.d was calculated.film thickness : film thicknesses were measured at five positions ( central and the four corners ) using the digital vernier caliper and the mean thickness was calculated.folding endurance study : it was measured manually by repeatedly folding a film at the same place till it broke.in vitro disintegration studies : the film as per the dimensions ( 3  2 cm ) required for dose delivery was placed on a stainless steel wire mesh placed in a petridish containing 10 ml phosphate buffer ph 6.8 . time required for the film to break was noted as in vitro disintegration time.dissolution and drug release : dissolution test of films was performed using ( 900 ml ; phosphate buffer ph 6.8 with usp dissolution apparatus ii at 50 rpm and 370.5c temperature . the drug release was analyzed spectrophotometrically at max 286.5 nm using ultraviolet ( uv ) spectrophotometer ( shimadzu model no : 1800 ) . morphological properties : properties such as homogeneity , color , transparency and surface of the oral films were evaluated by visual inspection . film mass : the mass of three films were determined by an analytical balance and means.d was calculated . film thickness : film thicknesses were measured at five positions ( central and the four corners ) using the digital vernier caliper and the mean thickness was calculated . folding endurance study : it was measured manually by repeatedly folding a film at the same place till it broke . in vitro disintegration studies : the film as per the dimensions ( 3  2 cm ) required for dose delivery was placed on a stainless steel wire mesh placed in a petridish containing 10 ml phosphate buffer ph 6.8 . dissolution and drug release : dissolution test of films was performed using ( 900 ml ; phosphate buffer ph 6.8 with usp dissolution apparatus ii at 50 rpm and 370.5c temperature . the drug release was analyzed spectrophotometrically at max 286.5 nm using ultraviolet ( uv ) spectrophotometer ( shimadzu model no : 1800 ) . all the formulation contained varied amount of polymer and hence thickness of each film was varied between the ranges of 0.14 mm-0.36 mm . when the concentration of hpmc e15 is increased from 5%-10% , thickness of the strip increased . folding endurance was measured manually and it was found to decrease with increase in the concentration of film forming polymer hpmc e15 . the surface ph of all the formulation was found to be in the range of 6.8 - 7.2 and hence will not cause any irritation to oral mucosa . f1 formulation found to give minimum disintegration time ( 45 sec ) as compared to other formulations . the drug release rate decreases as the concentration of the film forming agent hpmc e15 increases in the formulation . after 15 min interval more than 75% of drug was released from batches as defined in the guidances such as usp30 . films were prepared of domperidone--cyclodextrin solid dispersion by the use of hpmc e15 as a film forming agent and peg-400 as a plasticizer . domperidone mouth dissolving films were prepared successfully by the use of solid dispersion of domperidone with -cyclodextrin and it can be used to treat emesis caused by various conditions in geriatric , bedridden and non - cooperative patients due to its ease of production .