skin and soft tissue infections caused by non - tuberculous mycobacteria have been increasingly described as a complication associated with many procedures , including liposuction , illicit soft tissue augmentation , acupuncture , and contamination from medical instruments during surgery [ 1 , 2 , 3 , 4 , 5 ] . mycobacterium abscessus is a rapid - growing atypical mycobacterium that has been reported to cause a variety of cutaneous infections . herein , we report a case of cutaneous m. abscessus infection associated with mesotherapy injection . a previously healthy 44-year - old woman presented with a 3-week history of tender erythematous nodules on her face . the lesions had developed 2 weeks after mesotherapy injection for facial rejuvenation , using an unknown substance administered by an uncertified aesthetician . physical examination revealed multiple , discrete , tender erythematous nodules and plaques with minimal serosanguinous discharge on both cheeks ( fig . 1 ) and on the forehead ( fig . a skin biopsy specimen obtained from a nodule on the right cheek revealed dense inflammation predominantly consisting of neutrophils , histiocytes and multinucleated giant cells in the superficial and deep dermis ( fig . 3 ) . gram staining , fungal and acid - fast bacilli stains were negative . tissue culture was positive for m. abscessus , sensitive to clarithromycin , ciprofloxacin , doxycycline , cefoxitin , and amikacin . the patient was treated with a combination of clarithromycin 500 mg twice daily , doxycycline 100 mg twice daily , and ciprofloxacin 500 mg twice daily according to the bacterial sensitivity testing . the patient completed 6 months of treatment , which resulted in complete resolution of the lesions with minimal atrophic hyperpigmented scars . mesotherapy was first introduced in france in 1952 , consisting of an injection of highly diluted drugs and different substances into the dermis and subcutaneous tissue . this technique was originally developed to treat localized pain , vascular and lymphatic disorders , but its use in aesthetic medicine has increased in recent years . m. abscessus belongs to the group of rapidly growing non - tuberculous mycobacteria which is characterized by a rapid growth rate ( within 7 days ) on the culture . the organism is ubiquitously present in soil , decaying vegetation , and water ( e.g. , natural water , sewage water , drinking water tanks , and tap water ) . m. abscessus causes a wide range of clinical diseases including skin and soft - tissue infection , keratitis , osteomyelitis , pulmonary infection , and disseminated infection . in skin and soft - tissue infection , it usually follows penetrating trauma and typically occurs in immunocompetent individuals . there are several reports of outbreaks of m. abscessus infections caused by non - sterile techniques or contaminated materials , following surgery , liposuction , foreign body implantation , mesotherapy , acupuncture , and soft tissue augmentation [ 1 , 2 , 3 , 4 , 5 ] . the clinical presentations of cutaneous m. abscessus infection ranges from asymptomatic to tender erythematous violaceous nodules and plaques , cellulitis , abscesses , ulcer , and draining sinus with serosanguinous discharge . approximately 1020% of localized cutaneous m. abscessus infections in immunocompetent patients resolve spontaneously without treatment in an average of 8 months . currently , there is no standard guideline for the treatment of cutaneous m. abscessus infection . multiple modalities including surgery , draining of abscesses , removal of necrotic tissue , foreign body removal , and an extended course of antibiotics are recommended . however , the in vivo efficacy against the mycobacteria is not completely reflected by in vitro sensitivity alone , but also depends on the function of local and general host defenses against the infection . m. abscessus is usually susceptible to clarithromycin , amikacin , linezolid , tigecycline and variably susceptible to cefoxitin and imipenem ( table 1 ) . monotherapy is not recommended in treating m. abscessus infection because of the potential for emergence of antibiotic resistance , as has been reported with other mycobacteria , such as mycobacterium chelonae . in conclusion , we report a case of cutaneous m. abscessus infection associated with mesotherapy . this case emphasizes the importance of adequate sterile measures in all medical procedures and stresses the need to suspect the possibility of an atypical mycobacterium infection in patients who develop late - onset skin and soft tissue infection after cutaneous injury , injections , and surgical interventions , particularly if they do not respond to conventional antibiotic treatment .