The paloma (Spanish for "dove") is a tequila-based cocktail. This drink is most commonly prepared by mixing tequila with a grapefruit-flavored soda such as Fresca, Squirt, or Jarritos and served on the rocks with a lime wedge. This drink also has the option of adding salt to the rim of the glass.
Fresca is a grapefruit flavored soda.
Fresca is different flavors, so it can be, but not always.