"Makes No Difference" is the first single by Canadian rock band Sum 41. It was released in June 2000 as the lead single from the band's extended play "Half Hour of Power". The song is featured on the soundtracks for "Bring it On", "Out Cold" and "Van Wilder". A new version of the song was featured on Sum 41's greatest hits compilation, "All the Good Shit".
A new version of the song "Makes No Difference" was featured on Sum 41's greatest hits compilation, "All the Good Shit" using the same lyrics but different instrumentals.