Maryland Route 161 (MD 161) is a state highway in the U.S. state of Maryland. The state highway runs 5.38 mi from MD 155 in Hopewell Village north to U.S. Route 1 (US 1) in Darlington. MD 161 connects Havre de Grace with Susquehanna State Park and northeastern Harford County. The state highway was mostly constructed in the late 1920s and early 1930s.
Maryland Route 161 took 5 years to construct.