Isin is a Local Government Area in Kwara State, Nigeria. Isin Local Government Area of Kwara State was created from the old Irepodun Local Government Area in 1996 with the headquarters at Owu-Isin. It has an area of 633 km² and a population of 59,738 at the 2006 census.
The Isin headquarters are located in Owu-Isin.