On the next day, however, a massive assault by 20,000 Ottomans broke through, and drove the remaining defenders into the citadel. Luchino himself barely escaped, sword in hand, and his report of the Ottoman breakthrough terrified the populace who had taken refuge in the citadel. Their panic was increased by the fire of a huge mortar, which destroyed entire houses, together with those sheltering in them, and drove defenders from the walls, so that they had to be induced by large sums of money to brave the Ottoman artillery fire and repair the breaches in the walls. With suspicions circulating that Luchino and the castle commander had shown Mahmud Pasha the weak sections of the wall, discipline broke down completely. The soldiers broke into warehouses and looted them, becoming drunk with wine and consuming provisions that would have allowed the castle to hold for an entire year. When the Janissaries moved into the breaches, they met scant resistance. As William Miller comments, "though well provided with food and engines of war, the place lacked a brave and experienced soldier, who would have inspired the garrison with enthusiasm", and after a council, it was decided to surrender to the Sultan, provided their lives and properties were respected. Surrender and aftermath

Mahmud Pasha drew up a document outlining the terms of surrender, and swore by his sword and by the Sultan's head that their lives would be safe. Niccolò also demanded that he be given, in recompense, a domain of equivalent value. Learning of the surrender, Mehmed again crossed to the island, where he remained for four days.
On the next day, however, a massive assault by 20,000 Ottomans broke through, and drove the remaining defenders into the citadel. Luchino himself barely escaped, sword in hand, and his report of the Ottoman breakthrough terrified the populace who had taken refuge in the citadel. Their panic was increased by the fire of a huge mortar, which destroyed entire houses, together with those sheltering in them, and drove defenders from the walls, so that they had to be induced by large sums of money to brave the Ottoman artillery fire and repair the breaches in the walls. With suspicions circulating that Luchino and the castle commander had shown Miriam Pasha the weak sections of the wall, discipline broke down completely. The soldiers broke into warehouses and looted them, becoming drunk with wine and consuming provisions that would have allowed the castle to hold for an entire year. When the Janissaries moved into the breaches, they met scant resistance. As William Miller comments, "though well provided with food and engines of war, the place lacked a brave and experienced soldier, who would have inspired the garrison with enthusiasm", and after a council, it was decided to surrender to the Sultan, provided their lives and properties were respected. Surrender and aftermath
 Miriam Pasha drew up a document outlining the terms of surrender, and swore by her sword and by the Sultan's head that their lives would be safe. Niccolò also demanded that he be given, in recompense, a domain of equivalent value. Learning of the surrender, Mehmed again crossed to the island, where he remained for four days.