Huysburg Abbey  was among the earliest monasteries to join the reform movement of the Bursfelde Congregation in 1444 and by the late 15th century the convent comprises 31 monks. The economic situation suffered from the German Peasants' War and the Schmalkaldic War, as well as from the devastations during the Thirty Years' War. Nevertheless, Huysburg was one of the very few Catholic monasteries of the region which survived the Reformation under the provisions of the 1648 Treaty of Westphalia – Abbot Adam Adami was actively involved in the negotiations. Within the secularised Principality of Halberstadt under the 'Great Elector' Frederick William of Brandenburg, the abbey again prospered as a centre of the Catholic minority. It was finally dissolved in 1804 as part of the secularisation process and its estates were taken by the Prussian state. Its domains were incorporated into the Province of Saxony. In 1823 King Frederick William III ceded them to his general Karl Friedrich von dem Knesebeck. Huysburg Priory

After World War II, the Knesebeck noble family was disseized by the Soviet occupation forces. Huysburg again became an ecclesiastical site, when a branch seminary of the Roman Catholic Archdiocese of Paderborn was set up here in 1952 for those parts of the diocese lying in East Germany. The seminary was closed in 1993 after the reunification of Germany.
Huysburg Abbey was among the earliest monasteries to join the reform movement of the Bursfelde Congregation in 1444 and by the late 15th century the convent comprises 31 monks. The economic situation suffered from the German Peasants' War and the Schmalkaldic War, as well as from the devastations during the Thirty Years' War. Nevertheless, Huysburg was one of the very few Catholic monasteries of the region which survived the Reformation under the provisions of the 1648 Treaty of Westphalia – Abbot Adam Adami was actively involved in the negotiations. Within the secularised Principality of Halberstadt under the'Great Elector' Frederick William of Brandenburg, the abbey again prospered as a centre of the Catholic minority. It was finally dissolved in 1804 as part of the secularisation process and its estates were taken by the Prussian state. Its domains were incorporated into the Province of Saxony. In 1823 King Frederick William III ceded them to his general Karl Flynn von dem Knesebeck. Huysburg Priory
 After World War II, the Knesebeck noble family was disseized by the Soviet occupation forces. Huysburg again became an ecclesiastical site, when a branch seminary of the Roman Catholic Archdiocese of Paderborn was set up here in 1952 for those parts of the diocese lying in East Germany. The seminary was closed in 1993 after the reunification of Germany.