The JS43 was an evolution of 's relatively successful JS41, designed by Frank Dernie. However, he, team manager Tony Dowe and majority owner Tom Walkinshaw left the team after ownership problems with Ligier founder Guy Ligier. This paved the way for Alain Prost to buy the team for . Despite these losses, the JS43 performed respectably all season, with both chassis and engine the subject of steady development. Despite season-long complaints about the car's braking performance, Panis took his first and only Grand Prix victory at Monaco, in a race where only three cars finished. It was also Ligier's first win since the 1981 Canadian Grand Prix. Panis also finished sixth in Brazil and fifth in Hungary, to place ninth in the Drivers' Championship with 13 points. Diniz finished sixth in Spain and Italy, earning two points which placed him 15th in the Drivers' Championship. The Brazilian was also fortunate to escape a serious fire in Argentina. With a total of 15 points, Ligier placed sixth in the Constructors' Championship.
The JS43 was an evolution of's relatively successful JS41, designed by Frank Dernie. However, he, team manager Tony Dowe and majority owner Tom Walkinshaw left the team after ownership problems with Ligier founder Guy Ligier. This paved the way for Alain Prost to buy the team for. Despite these losses, the JS43 performed respectably all season, with both chassis and engine the subject of steady development. Despite season-long complaints about the car's braking performance, Panis took their first and only Grand Prix victory at Monaco, in a race where only three cars finished. It was also Ligier's first win since the 1981 Canadian Grand Prix. Panis also finished sixth in Brazil and fifth in Hungary, to place ninth in the Drivers' Championship with 13 points. Diniz finished sixth in Spain and Italy, earning two points which placed him 15th in the Drivers' Championship. The Brazilian was also fortunate to escape a serious fire in Argentina. With a total of 15 points, Ligier placed sixth in the Constructors' Championship.

