a ) the term “ patient refers to a warm - blooded animal , such as for example , rats , mice , dogs , cats , guinea pigs , and primates such as humans ; b ) the term “ treat ” refers to either preventing , providing symptomatic relief , or curing the patient &# 39 ; s disease , disorder or condition ; c ) the term “ administering ” comprises administration via any appropriate route such as oral , sublingual , buccal , transdermal , inhalation , rectal or injection ( including intramuscular , intravenous , subcutaneous , etc . ), or any other appropriate method of providing the compound to the patient ; d ) the term “ therapeutically sufficient amount ” means enough of the compound which becomes bioavailable through the appropriate route of administration to treat the patient for the disorder , condition or disease ; e ) the term “ pharmaceutically acceptable salt ” means either an acid addition salt or a basic addition salt which is compatible with the treatment of patients for the intended use . “ pharmaceutically acceptable acid addition salt ” is any non - toxic organic or inorganic acid addition salt of the base compounds represented by formula i . illustrative inorganic acids which form suitable salts include hydrochloric , hydrobromic , sulfuric and phosphoric acid and acid metal salts such as sodium monohydrogen orthophosphate and potassium hydrogen sulfate . illustrative organic acids which form suitable salts include the mono -, di - and tri - carboxylic acids . illustrative of such acids are , for example , acetic , glycolic , lactic , pyruvic , malonic , succinic , glutaric , fumaric , malic , tartaric , citric , ascorbic , maleic , hydroxymaleic , benzoic , hydroxybenzoic , phenylacetic , cinnamic , salicyclic , 2 - phenoxybenzoic , p - toluenesulfonic acid and sulfonic acids such as methanesulfonic acid and 2 - hydroxyethanesulfonic acid . either the mono - or di - acid salts can be formed , and such salts can exist in either a hydrated , solvated or substantially anhydrous form . in general , the acid addition salts of these compounds are more soluble in water and various hydrophilic organic solvents and which in comparison to their free base forms , generally demonstrate higher melting points . “ pharmaceutically acceptable basic addition salts ” means non - toxic organic or inorganic basic addition salts of the compounds of formula ( i ), if it can be made . examples are alkali metal or alkaline - earth metal hydroxides such as sodium , potassium , calcium , magnesium or barium hydroxides ; ammonia , and aliphatic , alicyclic , or aromatic organic amines such as methylamine , trimethylamine and picoline . the selection of the appropriate salt may be important so that the ester is not hydrolyzed . the selection criteria for the appropriate salt will be known to one skilled in the art . f ) the term “ restorative sleep ” means sleep which produces a rested state upon waking ; g ) the term “ sleep disorder ” means insomnia and obstructive sleep apnea ; h ) the term “ insomnia ” means primary insomnia , insomnia related to another mental disorder , and substance - induced insomnia ; i ) the term “ primary insomnia ” means difficulty in initiating sleep , in maintaining sleep or having restorative sleep which is not caused by a mental disorder or due to physiological effects of taking or withdrawing from certain substances ( substance - induced ). as used herein , it also includes circadian rhythm insomnia which is insomnia due to a change in the normal sleep - wake schedule ( shift changes , jet lag , etc . ); j ) the term “ insomnia related to another mental disorder ” means difficulty in initiating sleep , in maintaining sleep or having restorative sleep which is caused by an underlying mental disorder such as , for example , depression , anxiety or schizophrenia ; k ) the term “ substance - induced insomnia ” means difficulty in initiating sleep , in maintaining sleep or having restorative sleep which is caused by physiological effects of taking or withdrawing from certain substances such as caffeine , alcohol , amphetamine , opioids , sedatives , hypnotics and anxiolytics ; and l ) the term “ obstructive sleep apnea ” means repeated episodes of upper - airway obstruction during sleep and is normally characterized by loud snores or brief gasps that alternate with episodes of silence . the compound may be synthesized by methods known in the art , such as one previously described in u . s . pat . no . 5 , 134 , 149 , incorporated herein by reference . in step a of reaction scheme i , an esterification reaction is carried out between racemic α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol ( structure 1 ) and the (+)- isomer of α - methoxyphenylacetic acid ( structure 2 ). this esterification produces the diastereomeric mixture identified as structure 3 . these diastereomers are subjected to silica gel chromatography which separates the two diastereomers , thereby isolating the (+,+) diastereomer as is depicted in step b . in step c , the (+,+) diastereomer is hydrolyzed which produces the (+)- isomer of α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol . the esterification reaction can be carried out using techniques known in the art . typically approximately equivalent amounts of racemic α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol and the (+)- isomer of α - methoxyphenylacetic acid are contacted in an organic solvent such as methylene chloride , thf , chloroform , toluene and heated to reflux for a period of time ranging from 5 to 24 hours . the esterification is typically carried out in the presence of an equivalent amount of dicyclohexylcarbodiimide and a catalytic amount of 4 - dimethylaminopyridine . the resulting diastereomers can be isolated by filtration of the dicyclohexylurea and evaporation of the filtrate . the diastereomers are then subjected to silica gel chromatography which separates the (+,+) and the (−,+) diastereomers . this chromatographic separation may be carried out as is known in the art . a 1 : 1 mixture of hexane and ethyl acetate is one suitable eluent . the resulting (+,+) diastereomer is then subjected to a hydrolysis reaction which produces the (+)- isomer of α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidine - methanol . the hydrolysis is carried out by contacting the diastereomer with an excess of a base such as potassium carbonate in an aqueous alcoholic solution . the hydrolysis is carried out at a temperature of about 15 to 30 ° c . for a period of time ranging from 2 to 24 hours . the resulting (+)- isomer of α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol may then be recovered by dilution with water and extraction with methylene chloride . it is then purified by recrystallization from a solvent system such as cyclohexane / hexane or ethyl acetate / hexane . methods for producing the starting materials of reaction scheme i are known in the art . for example , u . s . pat . no . 4 , 783 , 471 teaches how to prepare racemic α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidine - methanol . this patent is hereby incorporated by reference . examples no . 1 and 2 of this application also teach suitable methods . alternatively , racemic α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol can be prepared in the following manner . initially 4 - hydroxypiperidine is subjected to an n - alkylation reaction with p - fluorophenylethyl bromide which produces 4 - hydroxy - 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- piperidine . this compound is brominated with ph 3 p . br 2 which produces 4 - bromo - 1 -[ 2 -( 4 - fluorophenyl ) ethyl ] piperidine . this compound is contacted with mg thereby forming a grignard reagent which is then reacted with 2 , 3 - dimethoxybenzaldehyde which produces the desired product (±)- α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol . the (+)- isomer of α - methoxyphenylacetic acid is known in the art . examples 1 , 2 and 3 show one method of making the compound . examples 4 and 5 provide data on the method of using the compound . example 1 , steps a - d , demonstrates the preparation of the starting material (±)- α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol , structure 1 . a solution of isonipectoamide ( 10 . 9 g , 85 . 0 mmol ), 2 -( 4 - fluorophenyl ) ethyl bromide ( 15 . 7 g , 77 . 3 mmol ), and k 2 co 3 ( 2 . 3 g , 167 mmol ) was prepared in dmf ( 280 ml ) and stirred under argon at 90 - 95 ° c . overnight . the cooled solution was concentrated to a white oily solid . the solid was partitioned between water and ch 2 cl 2 . the layers were separated and the aqueous layer was extracted with ch 2 cl 2 . the combined organic layers were washed 2 × with water , dried ( mgso 4 ), filtered , and evaporated to an oily solid . the solid was recrystallized from etoac to afford 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinecarboxamide as a white powder , m . p . 177 - 178 ° c . ( decomp .). anal . calcd . for c 14 h 19 fn 2 o : c , 67 . 18 ; h , 7 . 65 : n , 11 . 19 . found : c , 67 . 25 ; h , 7 . 67 ; n , 11 . 13 . to stirred phosphorus oxychloride ( 25 ml , 41 . 12 g , 268 mmol ) and sodium chloride ( 5 . 1 g , 87 . 3 mmol ) was added 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinecarboxamide ( 8 . 9 g , 35 . 6 mmol ) portionwise . after complete addition , the solution was refluxed for 2 hours . the cooled solution was poured into dilute nh 4 oh to destroy the pocl 3 . the aqueous solution was cooled to 0 ° c ., then extracted 2 × with ch 2 cl 2 . the combined organic layers were dried ( mgso 4 ), filtered , and evaporated to afford 8 . 1 g of an oily solid . the solid was distilled , ( b . p . 150 ° c ., 0 . 1 mm hg ), to afford a clear , colorless oil that solidified . this material was crystallized from hexane to afford 4 - cyano - 1 -[ 2 -( 4 - fluorophenyl ) ethyl ] piperidine as white needles , m . p . 47 - 48 ° c . anal . calcd . for c 14 h 17 fn 2 : c , 72 . 39 ; h , 7 . 38 ; n , 12 . 06 . found : c , 72 . 62 ; h , 7 . 49 ; n , 12 . 12 . to a stirred solution of 4 - cyano - 1 -[ 2 -( 4 - fluorophenyl )- ethyl ] piperidine ( 1 . 00 g , 4 . 3 mmol ) in thf ( 20 ml ) under argon at 0 ° c . was added dibal - h ( 4 . 6 ml of a 1 . 0 m solution in thf , 4 . 6 mmol ) via syringe . after stirring overnight at room temperature , 10 % aqueous hcl ( 25 ml ) was added and the solution was stirred for 3 hours . the entire mixture was then poured into 10 % aqueous naoh ( 50 ml ), then extracted 2 × with ether . the combined organic layers were washed with brine , dried ( mgso 4 ), filtered , and evaporated to afford a pale yellow oil . the oil was chromatographed on silica gel , eluting with etoac . the appropriate fractions were combined and evaporated to afford an oil . this oil was distilled ( b . p . 166 ° c ., 0 . 05 mm hg ) to afford 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinecarboxaldehyde , obtained as a colorless oil . anal . calcd . for c 14 h 18 fno : c , 71 . 46 ; h , 7 . 71 ; n , 5 . 95 . found : c , 71 . 08 ; h , 7 . 81 ; n , 5 . 86 . to a stirred solution of veratrole ( 0 . 93 g , 6 . 7 mmol ) in thf ( 20 ml ) under argon at 0 ° c . was added n - buli ( 2 . 7 ml of a 2 . 5 m solution in hexane , 6 . 75 mmol ). after stirring 2 . 5 h , the solution was cooled to − 78 ° c . and treated with 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinecarboxaldehyde ( 1 . 30 g , 5 . 5 mmol ) in thf ( 25 ml ) via an additional funnel . the cooling bath was removed and the solution was allowed to stir for 2 hours . water was added , the layers separated , and the aqueous layer was extracted with etoac . the combined organic layers were washed with brine , dried ( mgso 4 ), filtered , and chromatographed on silica gel , eluting with acetone . the appropriate fractions were combined and evaporated to afford a white solid . the solid was recrystallized from hexane to afford racemic α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol as shiny white needles , m . p . 126 - 127 ° c . anal . calcd . for c 22 h 28 fno 3 : c , 70 . 75 ; h , 7 . 56 ; n , 3 . 75 . found : c , 70 . 87 ; h , 7 . 65 ; n , 3 . 68 . example 2 , steps a - f , demonstrate an alternative manner of preparing (±)- α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol , structure 1 . to isonipecotic acid ( 107 . 5 g , 832 mmol ) stirred in 1n naoh ( 40 g naoh in 900 ml h 2 o ) and tert - butanol ( 1800 ml ) was added di - tert - butyl dicarbonate ( 200 g , 916 mmol ) in portions . after stirring overnight , the solution was concentrated and the resulting water layer was extracted 3 × with ether . the combined organic layers were washed with water , brine , dried ( mgso 4 ), filtered , and evaporated to a white solid , which was recrystallized from etoac / hexane ( 300 ml / 200 ml ) to afford 1 -( 1 , 1 - dimethylethyl )- 1 , 4 - piperidinedicarboxylic acid as white needles , m . p . 147 - 149 ° c . to a stirred solution of 1 -( 1 , 1 - dimethylethy )- 1 , 4 - piperidinedicarboxylic acid ( 50 . 0 g , 218 mmol ) in anhydrous ch 2 cl 2 ( 500 ml ) under n 2 in a 2l flask was added 1 , 1 ′- carbonyldiimidazole ( 38 . 9 g , 240 mmol ) portionwise . after stirring for 1 hour , n , o - dimethylhydroxylamine hydrochloride ( 23 . 4 g , 240 mmol ) was added in one portion . after stirring overnight , the solution was washed twice with 1n hcl , twice with saturated nahco 3 , once with brine , dried ( mgso 4 ), filtered , and evaporated to an oil . distillation afforded 4 -( n - methoxy - n - methylcarboxamido )- 1 - piperidinecarboxylic acid 1 , 1 - dimethylethyl ester as a clear oil , b . p . 120 - 140 ° c ., 0 . 8 mm . n - butyl lithium ( 14 . 5 ml of a 2 . 5 m solution in hexane , 36 . 3 mmol ) was added via syringe to a stirred solution of veratrole ( 5 . 00 g , 36 . 2 mmol ) in thf ( 50 ml , anhydrous ) under argon at 0 ° c . the ice bath was removed and the mixture was allowed to stir for 90 minutes . the mixture was cooled to − 78 ° c . and treated with 4 -( n - methoxy - n - methylcarboxamido )- 1 - piperidinecarboxylic acid 1 , 1 - dimethylethyl ester ( 9 . 20 g , 33 . 8 mmol ) in thf ( 50 ml , anhydrous ) via syringe . the cooling dry ice - acetone bath was removed and the mixture was allowed to come to room temperature . after stirring for 3 hours , saturated aqueous nh 4 cl was added and the mixture was allowed to stir overnight . the layers were separated and the aqueous layer was extracted with ether . the combined organic layers were washed with brine , dried ( mgso 4 ), filtered , and evaporated to afford an amber oil . the oil was chromatographed on silica gel , eluting with 20 % etoac in hexane . the appropriate fractions were combined and evaporated to an amber oil . the oil was distilled to afford 4 -( 2 , 3 - dimethoxybenzoyl )- 1 - piperidinecarboxylic acid 1 , 1 - dimethylethyl ester as a colorless oil . ( b . p . 225 - 250 ° c ., 0 . 05 mm ). anal . calcd . for c 19 h 27 no 5 : c , 65 . 31 ; h , 7 . 79 ; n , 4 . 01 . found : c , 65 . 04 ; h , 7 . 92 ; n , 4 . 11 . 4 -( 2 , 3 - dimethoxybenzoyl )- 1 - piperidinecarboxylic acid 1 , 1 - dimethylethyl ester ( 7 . 75 g , 22 . 2 mmol ) was dissolved in trifluoroacetic acid ( 50 ml , 650 mmol ) and stirred for 45 minutes . the entire solution was poured into ether ( 900 ml ) and allowed to stand overnight . filtration yielded 4 -( 2 , 3 - dimethoxyphenyl )- 4 - piperidinylmethanone trifluoroacetate as fine white needles , m . p . 123 ° c . anal . calcd . for c 14 h 19 no 3 . cf 3 co 2 h : c , 52 . 89 ; h , 5 . 55 ; n , 3 . 86 . found : c , 52 . 77 ; h , 5 . 62 ; n , 3 . 82 . the resulting 4 -( 2 , 3 - dimethoxyphenyl )- 4 - piperidinylmethanone trifluoroacetate was dissolved in water , treated with naoh ( 10 % aqueous ) until basic , and extracted three times with dichloromethane . the combined organic layers were washed with brine , dried ( mgso 4 ), filtered and evaporated to afford 4 -( 2 , 3 - dimethoxyphenyl )- 4 - piperidinylmethanone as an oil . a solution of 4 -( 2 , 3 - dimethoxyphenyl )- 4 - piperidinylmethanone ( 8 . 00 g , 32 . 1 mmol ) and 2 -( 4 - fluorophenyl ) ethyl bromide ( 6 . 52 g , 32 . 1 mmol ) was prepared in dmf ( 90 ml ) treated with k 2 co 3 ( 7 . 0 g , 50 . 7 mmol ), then stirred and heated at 80 ° c . under argon overnight . the cooled solution was poured into a partition of 2 / 1 etoac / toluene and water . the layers were separated and the aqueous layer was extracted with 2 / 1 etoac / toluene . the combined organic layers were washed 2 × with water , 1 × with brine , dried ( mgso 4 ), filtered , and evaporated to afford 11 . 0 g of an oil . the oil was chromatographed on silica gel , eluting with etoac . the appropriate fractions were combined , concentrated , dissolved in ethyl acetate and treated with hcl / ethyl acetate . ( 2 , 3 - dimethoxyphenyl )[ 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinyl ]- methanone monohydrochloride was obtained as a precipitate , m . p . 225 - 227 ° c . ( decomp ). anal . calcd . for c 22 h 26 fno 3 . hcl : c , 64 . 78 ; h , 6 . 67 ; n , 3 . 43 . found : c , 64 . 44 ; h , 6 . 73 ; n , 3 . 41 . to a stirred solution of ( 2 , 3 - dimethoxyphenyl )[ 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinyl ]- methanone ( 6 . 0 g , 16 . 2 mmol ) in meoh ( 100 ml ) at 0 ° c . was added nabh 4 ( 1240 mg , 32 . 8 mmol ) in two portions , over an one hour period . after stirring overnight , the solution was concentrated to a solid . the solid was partitioned between water and ether . the layers were separated and the aqueous layer was extracted with ether . the combined organic layers were washed with brine , dried ( mgso 4 ), filtered , and evaporated to a solid . the solid was chromatographed on silica gel , eluting with acetone . the appropriate fractions were combined and evaporated to afford a white solid . the solid was recrystallized from cyclohexane to afford (±)- α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl )- ethyl ]- 4 - piperidinemethanol as white needles , m . p . 126 - 127 ° c . anal . calcd . for c 22 h 28 fno 3 : c , 70 . 75 ; h , 7 . 56 ; n , 3 . 75 . found : c , 70 . 86 ; h , 7 . 72 ; n , 3 . 93 . a solution of 3 . 90 g ( 10 . 4 mmol ) of (±)- α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol , 1 . 74 g ( 10 . 4 mmol ) of s -(+)- α - methoxyphenylacetic acid , 2 . 15 g ( 10 . 4 mmol ) of 1 , 3 - dicyclohexylcarbodiimide and 0 . 1 g of 4 - dimethylaminopyridine in chloroform ( 75 ml ) was refluxed for 17 hours , allowing to cool to room temperature and filtered . the filtrate was concentrated and chromatographed on a silica gel column eluting with ethyl acetate / hexane ( 1 : 1 ) to afford two diastereomers , rf = 0 . 1 and 0 . 2 ( tlc etoac / hexane , 1 : 1 ). intermediate fractions were re - chromatographed to give additional material . those fractions with rf = 0 . 2 were combined to give a single diastereomeric ester , (+,+)-( 2 , 3 - dimethoxyphenyl )[ 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinyl ] methyl - α - methoxybenzene - acetate . to a stirred solution of 0 . 97 g ( 1 . 9 mmol ) of the above mentioned diastereomeric ester , rf = 0 . 2 , in 25 ml of methanol was added 0 . 5 g ( 3 . 6 mmol ) of potassium carbonate and 5 . 0 ml of water . after stirring 17 hours at room temperature the reaction mixture was diluted with water and extracted twice with methylene chloride . the combined extracts were washed with water , brine and dried over mgso 4 . after filtering , the filtrate was concentrated to an oil and crystallized from 40 ml of cyclohexane / hexane ( 1 : 1 ) to give (+)- α -( 2 , 3 - dimethoxyphenyl )- 1 -[ 2 -( 4 - fluorophenyl ) ethyl ]- 4 - piperidinemethanol , m . p . 112 - 113 ° c ., [ α ] d 20 =+ 13 . 9 °. the compound can be formulated into pharmaceutical dosage forms using techniques well known in the art . for oral administration , the compound can be formulated into solid or liquid preparations such as capsules , pills , tablets , lozenges , melts , powders , suspensions , or emulsions . solid unit dosage forms can be capsules of the ordinary gelatin type containing , for example , surfactants , lubricants and inert fillers such as lactose , sucrose , and cornstarch or they can be sustained release preparations . in another embodiment , the compound can be tableted with conventional tablet bases such as lactose , sucrose , and cornstarch in combination with binders , such as acacia , cornstarch , or gelatin , disintegrating agents , such as potato starch or algenic acid , and a lubricant such as stearic acid or magnesium stearate . liquid preparations are prepared by dissolving the active ingredient in an aqueous or non - aqueous pharmaceutically acceptable solvent which may also contain suspending agents , sweetening agents , flavoring agents , and preservative agents as are known in the art . for parenteral administration , the compound or its salts may be dissolved in a physiologically acceptable pharmaceutical carrier and administered as either a solution or a suspension . illustrative of suitable pharmaceutical carriers are water , saline , dextrose solutions , fructose solutions , ethanol , or oils of animal , vegetable , or synthetic origin . the pharmaceutical carrier may also contain preservatives , buffers , etc . as are known in the art . the dosage range at which the compound exhibits its ability to treat sleep disorders , including each specific type of sleep disorder , can vary depending upon the specific disorder , its severity , the patient , any underlying disease states that the patient is suffering from , and other medications that may be concurrently administered to the patient . generally though , this compound will exhibit its ability to treat sleep disorders at a range of 0 . 001 mg / kg / day to about 100 mg / kg / day . it may be delivered by any appropriate means , such as orally , sublingually , buccally , transdermally , rectal via suppository , inhalation or injection . a ) in five healthy subjects received a single 10 mg dose of the compound and seven subjects received a single 20 mg dose of the compound administered orally . forty percent of the subjects receiving the 20 mg dose ( 2 out of 5 ) and sixty percent of the subjects receiving the 10 mg dose ( 3 out of 5 ) experienced mild to moderate sedation . b ) forty - nine patients diagnosed with schizophrenia received either 10 mg of the compound ( 5 mg twice daily ), 20 mg of the compound ( 10 mg twice daily ), 40 mg of the compound ( 20 mg twice daily ) or placebo orally twice daily . the following was reported : placebo 10 mg 20 mg 40 mg total insomnia n = 1 ; n = 0 ; n = 3 : n = 3 ; n = 7 ; 14 . 3 % 0 % 21 . 4 % 23 . 1 % 14 . 3 % somnolence n = 0 ; n = 3 ; n = 1 ; n = 2 ; n = 6 ; 0 % 20 % 15 . 4 % 15 . 4 % 12 . 2 % the milligram ( mg ) amounts refer to the amount of the compound orally administered to the subjects and “ n ” refers to the number of subjects that reported the effect . this chart shows that although some insomnia was reported by some subjects having schizophrenia , some subjects also reported somnolence . c ) doses of 36 mg , 72 mg , 108 mg and 138 mg of the compound and placebo were orally administered to healthy subjects . the following data were reported . placebo 9 mg 18 mg 36 mg 72 mg 108 mg 138 mg n = 6 n = 4 n = 4 n = 4 n = 4 n = 4 n = 4 drowsiness 33 % 50 % 100 % 100 % 75 % 100 % 100 % n = 3 n = 2 n = 4 n = 4 n = 3 n = 4 n = 4 the drowsiness was rated as mild or moderate at doses below 72 mg and moderate to severe at 72 mg and above . d ) in healthy subjects , the compound was administered in 3 mg ( n = 4 ), 9 mg ( n = 4 ), 18 mg ( n = 4 ), 36 mg ( n = 4 ) and 72 mg ( n = 4 ) doses along with the placebo ( n = 5 ) wherein “ n ” is the number of subjects . only the group receiving the 72 mg dose reported drowsiness ( n = 3 ). intraperitoneal application of l - tryptophan ( 10 mg / kg ) and pargyline ( 50 mg / kg ) to anaesthetized newborn rats depressed the amplitude of the inspiratory discharges of the genioglossal muscle and induced obstructive apneas ( oa ). the following shows that the compound is efficient in preventing these effects and compares its efficiency to theophylline . experiments were carried out on newborn sprague dawley rats from iffa credo breeding center . the animals were anaesthetized by intraperitoneal injection of low doses of sodium pentobarbitone ( 7 - 10 mg / kg ), kept lying ( dorsal cubitus ) on a warming blanket and were spontaneously ventilating . the emg activity of the genioglossal muscles and the diaphragm were recorded with fine insulated wires ( bipolar recordings ) inserted within the muscles , filtered ( 100 - 3 , 000 hz ), amplified (× 5 - 10 , 000 ) and integrated ( time constant 50 ms ). the rib cage movements were recorded via a captor gently touching the lower ribs and / or the abdominal wall . the airflow changes resulting from the respiratory chest movements were recorded via a facial mask and a highly sensitive pressure recorder . effects of compound on depression of genioglossal emg induced by l - tryptophan and pargyline ten to fifteen minutes after induction of anesthesia , the animals received first an intraperitoneal injection of the compound , and a control recording was taken to define the mean amplitude of the integrated emgs . then , the animal received an intraperitoneal injection of l - tryptophan plus pargyline (“ l - trp + parg ”) 10 mg / kg and 50 mg / kg , respectively , and the changes in emg amplitudes were checked every 10 minutes and were expressed as % of control values . in ten animals , the pre - treatment with mdl 100 , 907 at 0 . 1 mg / kg did not prevent the depression of genioglossal ( gg ) discharge induced by injection of l - trp + parg . l - trp + parg injection significantly depressed by 30 - 50 % the mean gg discharge for about 30 minutes . a larger dose of the compound ( 1 mg / kg ) was applied in ten other newborn rats and this pre - treatment was now efficient in preventing the gg depression . finally , ten more animals received the largest dose used of the compound ( 3 mg / kg ) and confirmed the efficiency of the compound . effects of the compound pretreatment on the occurrence of obstructive apnea induced by l - tryptophan and pargyline injection the respiratory movements and resulting air flow changes were measured in 30 newborn rats which received first a pre - treatment with the compound at either 0 . 1 , 1 or 3 mg / kg and 10 min later l - trp + parg injection . l - trp + parg injection induced oas in 9 of 10 newborn rats which received the compound at 0 . 1 mg / kg , and 4 of the 10 animals eventually died of respiratory distress , similar to animals from previous studies which received l - trp + prg alone . five out of ten newborn rats which received the compound at 1 mg / kg did not present short lasting oas at all after l - trp + parg injection . among the 5 of 10 newborn rats which displayed oas , 2 animals had infrequent oas ( less than 5 short lasting oas in 60 minutes ). the mean curve calculated for the 1 mg / kg sample revealed a peak frequency of occurrence of short lasting oas between 20 - 40 min after the injection ( range 4 oas per 10 minute period ) which was significantly less than that observed in the 0 . 1 mg / kg sample . after 1 mg / kg pre - treatment with the compound , long lasting oas were observed in only one newborn rat and all animals survived to l - trp + parg injection . applying the largest dose of the compound ( 3 mg / kg ) confirmed the compound efficiency in preventing oas . only 2 of 10 treated rats presented frequent short lasting oas , 3 of 10 had a total of less than 3 short lasting oas , and 5 of 10 showed no short lasting oas . none of the 10 animals displayed long lasting oas and all survived . effects of theophylline pre - treatment on the occurrence of obstructive apneas induced by l - tryptophan and pargyline injection five newborn rats received theophylline at 10 mg / kg and 5 other animals received theophylline at 30 mg / kg . in both cases , l - trp + prg injection depressed the amplitude of gg inspiratory discharges and this effect was not prevented by either dose of theophylline . in a second set of experiments , induction of oas after l - trp + prg injection also was not prevented by theophylline at 10 or 30 mg / kg .
a process for making a pharmaceutical composition for treating a variety of sleep disorders comprising an effective amount of r -- α -- 1 - ethyl ]- 4 - piperidinemethanol or a pharmaceutically acceptable salt thereof is disclosed and claimed .