fig1 shows a syringe assembly 10 consisting of a syringe barrel 11 , piston 12 , and hypodermic needle 13 . also depicted is an injection vial 14 of neurotoxin which has been rendered into a solution 15 by injecting a fluid such as normal saline into the vial . afterwards , the needle 13 is inserted into the injection vial 14 and the piston 12 is withdrawn so as to fill the barrel 11 with the desired amount of neurotoxin solution 15 . it should be noted that the invention is not dependent on using a syringe 10 of the kind shown in the figures and that any method of applying a neurotoxin solution is acceptable such as swabs , pipettes , or pouring from glassware such as beakers . however , due to the typical packaging of neurotoxin in injection vials , the use of a hypodermic syringe and needle is preferred as this combination expedites the administration of the treatment . the type and volume of the syringe may encompass the kinds commonly used in the medical professions for hypodermic injections but it is preferred that the syringe be of a size that is easily held and controlled by the person administering the treatment and that the syringe have sufficient volume to hold all the neurotoxin solution required during the administration of the treatment . a needle ranging in gauge from 25 to 34 is preferred and ranging in gauge from 29 to 32 even more preferred . enough neurotoxin solution 15 should be prepared to carry the neurotoxin to the treatment area which it is covers . in addition , the solution should be made with sufficient neurotoxin to effect the treatment . the specific dilutions may vary depending on the particular neurotoxin formulation being administered . prior to the performance of the procedure , the patient is positioned in a chair in a semirecumbent position and the area of treatment exposed , for example , by removing clothing or jewelry in the vicinity of the area to be treated . towels may be placed around the area of treatment to isolate the treatment area and prevent hair or fabric from contacting the treatment area during the procedure . the outer surface of the skin in the area of the treatment is cleaned and disinfected by wiping with an antiseptic or disinfectant such as alcohol and allowing the skin to dry . fig2 depicts the procedure being conducted on a treatment area 22 of the neck 21 of a patient 20 . the hypodermic needle 13 is “ bounced ” across the treatment area 22 in a random but somewhat organized manner to produce serial punctures . as shown in fig3 , the point 16 of the needle 13 incises through the epidermis 30 into the dermis 31 but not into the hypodermis 32 . preferably , the punctures 23 are created by pushing downward with the face of the beveled portion of the point 16 oriented so that it is perpendicular to the surface of the skin . generally , the syringe 11 will be held at a 45 - degree angle to the skin and moved in a downward - and - upward motion perpendicular to the surface of the skin . the depth of the punctures 23 created by the needle 13 will vary depending on the thickness of the epidermis and dermis . the epidermis varies in thickness depending on the part of the body . its thickness can be up to a millimeter or more in areas such as the palms and soles and may be only a tenth of a millimeter over the eyelids but is generally about a half - millimeter over most of the body . the dermis ranges one to four millimeters in thickness being about half a millimeter over the eyelids and several millimeters over portions of the back . in the more commonly areas receiving the treatment , such as the neck , the punctures 23 are made to a depth of less than 1 millimeter and generally less than 0 . 5 millimeters using a 31 gauge needle 13 . the process of creating punctures is continued until mild erythema 24 is present over the treatment area 22 as shown in fig4 . in some cases , pinpoint bleeding may occur . at this point , the needle 13 is positioned close to but not touching the skin and the piston 12 of the hypodermic syringe 10 is very slowly depressed to apply small drops of the neurotoxin solution 15 over the area encompassed by the punctures 23 until the treatment area 22 is covered by a thin film of neurotoxin solution 15 as shown in fig5 . additional punctures 23 are then made into the treatment area 22 with particular attention paid to the problem areas such as skin lines , crepiness , excess skin , platysmal bands , and uneven skin tone and color . afterwards , more drops of neurotoxin solution 15 are applied in the manner just described . all the neurotoxin solution 15 is allowed to absorb into treatment and none is blotted . however , a gloved finger 60 may be used to rub the treatment area 22 to facilitate the absorption of the neurotoxin solution 15 . by the end of the procedure , the treatment area will be covered by about five to ten punctures per square centimeter . in the preferred embodiment , about 1 cubic centimeter of bonta solution will be applied to a treatment area on the neck having an area of about 100 square centimeters . the solution will typically take about 5 minutes to absorb into the skin after cessation of creating the punctures . it should be noted that the number of punctures per square centimeter to allow absorption of the neurotoxin solution will vary depending on the characteristics of the skin such as thickness and permeability and in some instances a lesser or greater number of punctures may be required than the five to ten typically associated with the treatment of the skin surface over the neck . following the procedure , the treatment area is kept clean and not wiped or washed for at least two hours . the patient is also instructed not to engage in any activity that might induce appreciable sweating at or near the treatment area such as physical activity and to avoid exposure to heat or sunlight . use of a botulinum toxin to treat rhytids , skin laxity , texture , tone , and color irregularities of the neck a 50 year - old female patient with an “ aging neck ” exhibiting rhytids , skin laxity , texture , tone , and color irregularities was treated using the method . an area of about 100 square centimeters was treated by applying small punctures in accordance with the method previously described until the treatment area exhibited pinpoint bleeding , erythema , and edema , about 25 units of botox ( onabotulinumtoxin a marketed by allergan , inc . ), diluted with normal saline was initially applied over the treatment area and gently rubbed until the solution was absorbed by the skin . a subsequent round of punctures were made to the treatment area followed by the application and absorption of the remainder of the botox solution so that a total of 50 units was applied to and absorbed by the skin and hemostasis was achieved . the treatment was repeated two weeks later . clinically - significant improvement was noted with respect to rhytids , skin laxity , texture , tone , and color irregularities . the patient reported very high satisfaction with the results and no difficulties in swallowing or decrease in neck strength was noted . positive effects lasted for at least three months based on the observations by the treating physician and subjective reports by the patient . as will be apparent to a person skilled in the art , a number of variations and modifications can be made to the structure described above without departing from the spirit and scope of the present invention .
a method for treating skin by administration of a neurotoxin such as a botulinum toxin by means of a dry needle . the method can be used to accomplish what has generally been described as skin rejuvenation and also to treat skin disorders such as skin lines , crepiness , excess skin , wrinkles , platysmal bands , uneven skin tone and color , and hyperhidrosis .