the invention encompasses a transdermal delivery of a combined composition containing hydrocortisone and a resveratrol composition . each of the hydrocortisone and resveratrol composition is formulated utilizing particular ratios that have been shown to have an advantageous synergistic effect in effectuating trans - dermal drug delivery . in a preferred embodiment , the present invention encompasses formulation of hydrocortisone and resveratrol in a shampoo composition . the composition includes a plurality of components to enhance the nanotechnological delivery of the active components through the skin . in one embodiment , the shampoo has a formulation as in table 1 below . in a preferred embodiment , when formulated as a shampoo , a base is prepared starting with acrylate crosspolymer - 4 in water . although many materials are suitable and known for shampoo formulation in general and particularly for a formulation with a desired viscosity , the selected acrylate crosspolymer - 4 is selected based on the characteristics of imparting a desired viscosity and compatibly with the nanotechnology delivery components . this particular component in the above - stated range is particular for compatibility for both the active materials of hydrocortisone and resveratrol . a preferred acrylate crosspolymer - 4 is carbopol aqua sf - 2 polymer ( available from lubrizol , wickcliffe , ohio ). additionally , the initial base is prepared with panthenol , caffeine and tetrasodium edta . once the initial base is prepared and a solution is obtained , various components selected with particularity and criticality as to percentage composition and chemistry are added to the base . the next step includes adding glycol distearate , cocamide dea , and cocamidoproplbetaine with glycerin . additionally , glycol stearate , cocamide mea , glycol distearate , sodium lauroyl methyl isethionate , cholecalciferol and zea mays are added to the base . although it is well known in the art that there are numerous surfactant bases suitable for shampoos in general and medical shampoos in particular , it has been discovered in formulas of the present invention that in order to deliver hydrocortisone and resveratrol utilizing a nano technology delivery system a sulfate free surfactant needs to be utilized . in a preferred embodiment the surfactant of the present invention incorporates approximately 10 to 30 percent of sodium lauroyl sarcocinate . a preferred material is available from rita corporation and sold as ritafactant ls - 30 . this material is selected with particularity as to composition and to percentage used in the formulation of the present invention in order to provide improved delivery of the active in a nanotechnology delivery system . in a preferred embodiment micronized hydrocortisone is utilized . hydrocortisone is present in a range of 0 . 1 to 1 . 0 percent w / w . the particular micronization properties require a preferred material that has a particle size of not less than 90 percent of the particles less than or equal to five microns . although , as stated herein , 90 % is less than 5 microns , it is generally understood in the art that particle size measurements are typically measured and presented as a gaussian curve with the major portion of the curve demonstrating particle size between about 1 to 5 microns . in a preferred embodiment , the shampoo is produced in a method as now described . water , acrylates crosspolymer - 4 , panthenol , caffeine , and tetrasodium edta — in order in a suitable main kettle and mixed under propeller agitation . once desired temperature is reached , add the following while maintaining temperature and mixing . glycol distearate , cocamide dea , cocamidopropylbetaine , glycerin , glycol stearate , cocamide mea , glycol distearate , sodium lauroyl methyl isethionate , cholecalciferol , and zea mays ( corn ) oil . once steps 1 - 2 are at 78 ° c .- 80 ° c ., add , in order : continue to mix until all ingredients are dissolved and maintain temperature at 78 ° c .- 80 ° c . when a uniform mixture is achieved , cool the batch to 70 ° c .- 75 ° c . when the batch is 70 °- 75 ° c ., add : when a uniform mixture is achieved , cool the mixture to 45 ° c .- 50 ° c . when a uniform mixture is achieved , cool the mixture 40 ° c . and add : in a second , or auxiliary vessel , premix the following ingredients in advance under homogenizer agitation and mix until thoroughly dispersed : add the mixture from the second vessel to the main vessel ( steps 1 - 6 ) where the main vessel is at 40 ° c . the adding of the secondary vessel components are added to the main vessel under propeller agitation . when the mixture of step 7 is uniform , cool the batch to 35 ° c . and add : camellia sinensis leaf extract ( and ) water ( and ) glycerin , tocopheryl acetate , magnesium ascorbyl phosphate , retinylpalmitate , and cholecalciferol ( and ) zea mays ( corn ) oil . in a third vessel , premix ingredients under propeller agitation and mix until clear and uniform . the phase can optionally be warmed to 40 ° c . while mixing : methyldihydrojasmonate , amyl salicylate , isobutyl methyl tetrahydropyranol , ethylene brassylate , 2 ,- dimethyl - 7 - octen - 2 - ol , linalool , tetramethylacetyloctahydronaphthalenes , phenethyl alcohol , oxacyclohexadecenone , methylenedioxyphenylmethylpropanal , coriandrumsativum ( coriander ) fruit oil isopropylphenylbutanal , decanal , ppg - 5 ceteth - 20 , and styrene / acrylates copolymer . when the main product batch ( steps 1 - 8 ) is at 35 ° c ., add premixed step 9 mixture to main product batch under propeller agitation . mix until uniform . when the batch is uniform , add styrene / acrylates copolymer and mix until uniform . when the batch is uniform , take the ph of the batch and use ( citric acid 50 % solution ) to adjust the ph to 5 . 50 - 6 . 00 . after the ph has been adjusted , take the viscosity of the batch . vicosity can be measured in any acceptable manner including dynamic and kinematic measurements . a preferred measurement is using brookfield rvt ; spindle : 4 ; speed : 20 rpm ; time : 1 minute ). a nacl solution is used as needed to adjust the viscosity to 3 , 500 - 5 , 000 cps . each of ph and viscosity are measured between 25 ° c . to 30 ° c . care is taken , as it is known in the art that viscosity of surfactant - based compositions is correlated to a salt concentration gradient . when the viscosity is either in the desired range or has been adjusted into the desired range , the composition is cooled to 30 ° c . and discharge into suitable storage containers . the present invention has discovered the enhanced nanotechnological delivery of a hydrocortisone - resveratrol composition based on the discovered base formulation and synergistic ratio of hydrocortisone : resveratrol composition . the result will provide enhanced absorption therapy over known compositions . in one embodiment , the nanotechnolgical delivery system of the present invention is prepared as any of a cream , lotion , ointment , or gel . the cream will utilize the advantageous novel ratio of hydrocortisone , resveratrol , lecithin , and glycerin to deliver the actives in the novel nanotechnological delivery system discovered and disclosed herein . in one embodiment , it has further been discovered that hydrocortisone formulated according to the present invention , while omitting resveratrol maintains an acceptable level of efficacy for delivery though the skin . while the invention has been described in its preferred form or embodiment with some degree of particularity , it is understood that this description has been given only by way of example and that numerous changes in the details of construction , fabrication , and use , including the combination and arrangement of parts , may be made without departing from the spirit and scope of the invention .
a composition is provided having nano technological delivery of a medicament through the skin . the composition contains hydrocortisone , resveratrol and a sulfate free surfactant . the composition is formulated into a shampoo and the shampoo facilitates nano technological delivery of the hydrocortisone and the resveratrol through the skin of a user .