the preferred active compounds of the present invention are in an ionized , salt form or as the free base of the pharmaceutically acceptable salts thereof ( provided , for the aerosol or pump spray compositions , they are soluble in the spray solvent ). these compounds are soluble in the non - polar solvents of the invention at useful concentrations or can be prepared as pastes at useful concentrations . these concentrations may be less than the standard accepted dose for these compounds since there is enhanced absorption of the compounds through the oral mucosa . this aspect of the invention is especially important when there is a large ( 40 - 99 . 99 %) first pass effect . as propellants for the non polar sprays , propane , n - butane , iso - butane , n - pentane , iso - pentane , and neo - pentane , and mixtures thereof may be used . n - butane and iso - butane , as single gases , are the preferred propellants . it is permissible for the propellant to have a water content of no more than 0 . 2 %, typically 0 . 1 - 0 . 2 %. all percentages herein are by weight unless otherwise indicated . it is also preferable that the propellant be synthetically produced to minimize the presence of contaminants which are harmful to the active compounds . these contaminants include oxidizing agents , reducing agents , lewis acids or bases , and water . the concentration of each of these should be less than 0 . 1 %, except that water may be as high as 0 . 2 %. suitable non - polar solvents for the capsules and the non - polar sprays include ( c 2 - c 24 ) fatty acid ( c 2 - c 6 ) esters , c 7 - c 18 hydrocarbon , c 2 - c 6 alkanoyl esters , and the triglycerides of the corresponding acids . when the capsule fill is a paste , other liquid components may be used instead of the above low molecular weight solvents . these include soya oil , corn oil , other vegetable oils . as solvents for the polar capsules or sprays there may be used low molecular weight polyethyleneglycols ( peg ) of 400 - 1000 mw ( preferably 400 - 600 ), low molecular weight ( c 2 - c 8 ) mono and polyols and alcohols of c 7 - c 18 linear or branch chain hydrocarbons , glycerin may also be present and water may also be used in the sprays , but only in limited amount in the capsules . it is expected that some glycerin and water used to make the gelatin shell will migrate from the shell to the fill during the curing of the shell . likewise , there may be some migration of components from the fill to the shell during curing and even throughout the shelf - life of the capsule . therefore , the values given herein are for the compositions as prepared , it being within the scope of the invention that minor variations will occur . the preferred flavoring agents are synthetic or natural oil of peppermint , oil of spearmint , citrus oil , fruit flavors , sweeteners ( sugars , aspartame , saccharin , etc . ), and combinations thereof . the compositions may further include a taste mask . the term “ taste mask ” as used herein means an agent that can hide or minimize an undesirable flavor such as a bitter or sour flavor . a representative taste masks is a combination of vanillin , ethyl vanillin , maltol , iso - amyl acetate , ethyl oxyhydrate , anisic aldehyde , and propylene glycol ( commercially available as “ pfc 9885 bitter mask ” from pharmaceutical flavor clinic of camden , n . j .). a taste mask in combination with a flavoring agent is particularly advantageous when the active compound is an alkaloid since alkaloids often have a bitter taste . the active substances include the active compounds selected from the group consisting of cyclosporine , sermorelin , octreotide acetate , calcitonin - salmon , insulin lispro , sumatriptan succinate , clozepine , cyclobenzaprine , dexfenfluramine hydrochloride , glyburide , zidovudine , erythromycin , ciprofloxacin , ondansetron hydrochloride , dimenhydrinate , cimetidine hydrochloride , famotidine , phenytoin sodium , phenytoin , carboprost thromethamine , carboprost , diphenhydramine hydrochloride , isoproterenol hydrochloride , terbutaline sulfate , terbutaline , theophylline , albuterol sulfate and neutraceuticals , that is to say nutrients with pharmacological action such as but not limited in another embodiment , the active compound is an endocrine modulator , glucose production inhibitor , agent for treatment of type ii diabetes , anti - secretory agent , glycolipid , glycoprotein , anti - hyperthyroid agent , thyroid hormone , or a mixture thereof . in one embodiment the active compound is an endocrine modulator . suitable endocrine modulators for use in the buccal sprays of the invention include , but are not limited to , methimazole , voglibose , finasteride , gi198745 , liothyronine , glyburide , metformin , nateglinide , ioglitazone , pegvisomant , minoxidil , and mixtures thereof . in one embodiment the active compound is a glucose production inhibitor . suitable glucose production inhibitors for use in the buccal sprays of the invention include , but are not limited to , acarbose , acetohexamide , chlorpropamide , glipizide , glyburide , metformin , miglitol , nateglinide , pioglitazone , rosiglitazone , tolbutamide , tolazamide , and mixtures thereof . in one embodiment the active compound is an agent for treatment of type ii diabetes . suitable agents for treatment of type ii diabetes for use in the buccal sprays of the invention include , but are not limited to , acarbose , acetohexamide , chlorpropamide , glipizide , glyburide , metformin , miglitol , nateglinide , pioglitazone , rosiglitazone , tolbutamide , tolazamide , and mixtures thereof . in one embodiment the active compound is an anti - secretory agent . suitable anti - secretory agents for use in the buccal sprays of the invention include , but are not limited to , esomeprazole , lansoprazole , omeprazole , pantoprazole , rabeprazole , tenetoprazole , ecabet , misoprostol , teprenone , and mixtures thereof . in one embodiment the active compound is a glycolipid . suitable glycolipids for use in the buccal sprays of the invention include , but are not limited to imigulcerase , vancomycin , vevesca ( ogt 918 ), gmk vaccine , and mixtures thereof . in one embodiment the active compound is a glycoprotein . suitable glycoproteins for use in the buccal sprays of the invention include , but are not limited to , staphvax , bimosiamose ( tbc1269 ), gcs - 100 , heparin , and mixtures thereof . in one embodiment the active compound is an anti - hyperthyroid agent . suitable anti - hyperthyroid agents for use in the buccal sprays of the invention include , but are not limited to , methimazol , propylthiouracil , and mixtures thereof . in one embodiment the active compound is a thyroid hormone . a suitable thyroid hormone for use in the buccal sprays of the invention includes , but is not limited to , levothyroxine . in one embodiment , the active compound is testosterone or a pharmaceutically acceptable ester thereof . typically , when the active compound is testosterone or a pharmaceutically acceptable ester thereof the buccal spray composition contains form about 0 . 01 to 20 weight / weight ( w / w ) percent testosterone , preferably , about 0 . 1 to 15 w / w percent , and more preferably about 0 . 2 to 10 w / w percent testosterone or a pharmaceutically acceptable ester thereof . suitable esters of testosterone that can be used in the compositions and methods of the invention . these include , but are not limited to , testosterone propionate ( testex ®), testosterone enanthate ( delatestry ®), and testosterone cypionate ( depotestosterone ®). the invention further relates to a method of treating hypogonadism in a patient by spraying the oral mucosa of the patient with a therapeutically effective amount of a buccal spray comprising testosterone or a pharmaceutically acceptable ester thereof . the invention further relates to a method of improving muscle development in a patient by spraying the oral mucosa of the patient with a therapeutically effective amount of a buccal spray comprising testosterone or a pharmaceutically acceptable ester thereof . the invention further relates to a method of stimulating erythropoiesis in a patient by spraying the oral mucosa of the patient with a therapeutically effective amount of a buccal spray comprising testosterone or a pharmaceutically acceptable ester thereof . the invention further relates to a method of treating anemia in a patient by spraying the oral mucosa of the patient with a therapeutically effective amount of a buccal spray comprising testosterone or a pharmaceutically acceptable ester thereof . in one embodiment , the anemia is associated with failure of bone marrow , myelofibrosis , or renal failure . the invention further relates to a method of treating angioneurotic edema in a patient by spraying the oral mucosa of the patient with a therapeutically effective amount of a buccal spray comprising testosterone or a pharmaceutically acceptable ester thereof . the invention further relates to a method of treating growth retardation in a patient by spraying the oral mucosa of the patient with a therapeutically effective amount of a buccal spray comprising testosterone or a pharmaceutically acceptable ester thereof . the invention further relates to a method of treating carcinoma of the breast in a women by spraying the oral mucosa of the women with a therapeutically effective amount of a buccal spray comprising testosterone or a pharmaceutically acceptable ester thereof the invention further relates to a method of treating osteoporosis in a patient by spraying the oral mucosa of the patient with a therapeutically effective amount of a buccal spray comprising testosterone or a pharmaceutically acceptable ester thereof . the formulations of the present invention comprise an active compound or a pharmaceutically acceptable salt thereof . the term “ pharmaceutically acceptable salts ” refers to salts prepared from pharmaceutically acceptable non - toxic acids or bases including organic and inorganic acids or bases . when an active compound of the present invention is acidic , salts may be prepared from pharmaceutically acceptable non - toxic bases . salts derived from all stable forms of inorganic bases include aluminum , ammonium , calcium , copper , iron , lithium , magnesium , manganese , potassium , sodium , zinc , etc . particularly preferred are the ammonium , calcium , magnesium , potassium , and sodium salts . salts derived from pharmaceutically acceptable organic non - toxic bases include salts of primary , secondary , and tertiary amines , substituted amines including naturally occurring substituted amines , cyclic amines and basic ion - exchange resins such as arginine , betaine , caffeine , choline , n , n dibenzylethylenediamine , diethylamine , 2 - diethylaminoethanol , 2 - dimethyl - aminoethanol , ethanolamine , ethylenediamine , n - ethylmorpholine , n - ethylpiperidine , glucamine , glucosamine , histidine , isopropylamine , lysine , methyl - glucosamine , morpholine , piperazine , piperidine , polyamine resins , procaine , purine , theobromine , triethylamine , trimethylamine , tripropylamine , etc . when an active compound of the present invention is basic , salts may be prepared from pharmaceutically acceptable non - toxic acids . such acids include acetic , benzenesulfonic , benzoic , camphorsulfonic , citric , ethane - sulfonic , fumaric , gluconic , glutamic , hydrobromic , hydrochloric , isethionic , lactic , maleic , mandelic , methanesulfonic , mucic , nitric , pamoic , pantothenic , phosphoric , succinic , sulfuric , tartaric , p - toluenesulfonic , etc . particularly preferred are citric , hydrobromic , maleic , phosphoric , sulfuric , and tartaric acids . in the discussion of methods of treatment herein , reference to the active compounds is meant to also include the pharmaceutically acceptable salts thereof . while certain formulations are set forth herein , the actual amounts to be administered to the mammal or man in need of same are to be determined by the treating physician . the invention is further defined by reference to the following examples , which are intended to be illustrative and not limiting . the following are examples of certain classes . all values unless otherwise specified are in weight percent . cns active amines and their salts : including but not limited to tricyclic amines , gaba analogues , thiazides , phenothiazine derivatives , serotonin antagonists and serotonin reuptake inhibitors
buccal aerosol sprays or capsules using polar and non - polar solvent have now been developed which provide testosterone for rapid absorption through the oral mucosa , resulting in fast onset of effect . the buccal polar compositions of the invention comprise formulation i : aqueous polar solvent , testosterone or a pharmaceutically acceptable ester thereof , and optional flavoring agent ; formulation ii : aqueous polar solvent , testosterone or a pharmaceutically acceptable ester thereof , optionally flavoring agent , and propellant ; formulation iii : non - polar solvent , testosterone or a pharmaceutically acceptable ester thereof , and optional flavoring agent ; and formulation iv : non - polar solvent , testosterone or a pharmaceutically acceptable ester thereof , optional flavoring agent , and propellant ; formulation v : a mixture of a polar and a non - polar solvent , testosterone or a pharmaceutically acceptable ester thereof , and optional flavoring agent ; formulation vi : a mixture of a polar and a non - polar solvent , testosterone or a pharmaceutically acceptable ester thereof , optional flavoring agent , and propellant .