there are a great many different implementations of the invention possible , too many to possibly describe - herein . some possible implementations that are presently preferred are described below . it cannot be emphasized too strongly , however , that these are descriptions of implementations of the invention , and not descriptions of the invention , which is not limited to the detailed implementations described in this section but is described in broader terms in the claims . this discovery that the defibrillation shock should be synchronized with the early portion of the decompression ( diastolic ) phase of chest compressions was in part the result of the development by the inventors of a new method for testing of defibrillation thresholds ( dfts ). when comparing the efficacy of a therapeutic intervention to an experimental control in the animal model , the dft is measured for treatment and control separately and then the dft levels are compared . a so - called dft50 is the defibrillation energy for a particular treatment at which on average the shock success rate is 50 %. to achieve statistical significance , multiple dfts are performed in sequence with the order of tests between treatment and control randomized . unfortunately , the process of induction of ventricular fibrillation in the experimental animal is physiologically deleterious due to the extended periods of anoxia . as a result , the underlying state of the animal and the associated statistics is non - stationary and differences in treatment effect are often obfuscated by unavoidable drift in the dfts as the animal &# 39 ; s physiological state degrades over time . the inventors have developed a method whereby the treatments that are desired to be compared are grouped together with a small number ( on the order of 1 - 5 ) of repeated measures in random sequence with all defibrillation levels for the treatments in the group set to the same level and a block size small enough so that the statistics of the animal &# 39 ; s state can be considered stationary . then a standard dft50 test would be performed on the block of treatments . so , as an example , if there are four different synchronization phases that are to be compared , each block would have 3 measures for each of the different phases , for a total of 12 shocks , with each of the shocks set to the same energy level . if it is found that the shock success rate for the group of 12 is above 50 % then the energy level is dropped for the next block of 12 ; if the shock success rate is below 50 %, then the energy level of the next block will be increased . in this manner , the aggregate shock success rate is maintained at 50 % over time . if there is a therapeutic difference between the various treatments , it can be detected using standard tests on proportions such as the chi - square test with a greater degree of sensitivity and repeatability . in a study of 15 swine , defibrillation was synchronized to various points in the chest compression cycle . the study was carried out in a 25 kg porcine ac - induced vf model . for each porcine model , the following four different coupling phases were tested : cpa : 20 ms before the onset of compression ; cpb : 130 ms after the onset of compression ; cpc : 20 ms before the onset of decompression ; cpd : 130 ms after the onset of decompression . each animal was preanesthetized with an im mixture of telazol ( 4 . 4 mg / kg ), ketamine ( 2 . 2 mg / kg ), and xylazine ( 2 . 2 mg / kg ) or the combination of ketamine ( 20 mg / kg ) and xylazine ( 2 mg / kg ). atropine ( 0 . 05 mg / kg ) given im was used to dry oral - tracheal secretion and prevent bradycardia during intubation or cut - down surgery . following the placement of a venous line in the ear ( lateral or medial auricular vein ), isoflurane anesthesia ( 0 . 8 - 3 . 2 %) was administered . the animal was then be intubated using vygon cfv endotracheal tube model and be supplied with constant o2 flow of 5 l / min using the constant pressure technique . a hp doppler transesophageal transducer was also placed into its esophagus and was connected to a hp echocardiographic system to record and characterize bemodynamic and dynamic changes in heart anatomy during autopulse ( mechanical chest compressor ) cpr . animals were monitored by heart rate , corneal reflexes , and by arterial pressures throughout the experiment . femoral or jugular arterial and venous access sheaths was placed , using a cut - down or percutaneous access approach . the arterial sheath was used to continuously monitor systemic blood pressure during the procedure . the peripheral venous sheath was used to administer intravenous fluids throughout the procedure . a 4 french pigtail catheter was advanced through the femoral arterial sheath . the lv pressure was measured using the pigtail catheter ( bard , murray hill , n . j .) positioned apically in the left ventricle through the femoral artery . the catheter was connected to a pressure transducer ( schneider namic , glens falls , n . y .) and pressure recordings were acquired and digitized using the mp100 data acquisition system . following preparation , the animal was put on the mechanical chest compressor ( autopulse , zoll medical ma ). the device delivers a compression via a spindle take - up system of a load - distributing band that is wrapped around the subject &# 39 ; s thorax . a force transducer that is integral to the autopulse measures the downward forces produced by the compression cycles delivered by the autopulse . a continuous analog signal proportional to force measured by the force transducer is output via a connector on the autopulse . referring to fig1 , in the preferred embodiment , synchronization between the chest compression 12 and defibrillation is accomplished by a communications connection 18 , via either a hardwire or wireless connection , between a separate defibrillator 10 and a mechanical chest compression device 15 . in some implementations , these devices are the e - series defibrillator ( zoll medical , chelmsford mass .) and the autopulse mechanical chest compressor ( zoll circulation , sunnyvale calif .). there are two connectors on the autopulse : 1 ) the force transducer output ( fto ) connector ; and 2 ) the high voltage ( hv ) connector . communication 18 is achieved via a hardwired connection of the defibrillator high voltage ( dhv ) cable into the fro connector . self adhesive defibrillation pads are attached to the patient for delivery of therapeutic defibrillation current , and are connected to the hv connector . inside the autopulse , the high voltage wires of the dhv cable are interconnected with the hv connector output to the defibrillation pads . the transducer output from the autopulse are connected to analog input lines on the dhv cable via the fto connector . in the experimental protocol to test efficacy of synchronization of defibrillation and compression , ventricular fibrillation ( vf ) was induced using direct current supplied by a 9 v battery and applied to the right ventricle , and was permitted to persist for 30 seconds prior to an autopulse cpr . following the 30 second period of autopulse cpr , a predetermined shock energy was delivered to attempt to defibrillate the vf in a predetermined coupling phase . if the shock fails to defibrillate , then a rescue shock was delivered using the same defibrillation device used to deliver the failed defibrillation shock . the outcome of the shock was recorded , the animal was permitted to stabilize hemodynamically for four minutes , and then the sequence ( fibrillate , autopulse cpr , defibrillate , rescue ) was performed using the next predetermined defibrillation shock in a predetermined coupling phase . the detailed protocol follows : 1 . record 5 seconds of autopulse load cell signal ( without defib shocks ), play it back and check if shocking phases ( 77 ms , 365 ms , 526 ms , 564 ms , 688 ms ) need to be adjusted ; 2 . select first test energy = 1 . 7 * weight ( kg ), rounding off to 5 ; 3 . place a pair of stat . padz , adult defib pads in lateral - to - lateral configuration . 4 . randomize shocking sequences ( 77 ms , 365 ms , 526 ms , 564 ms , 688 ms ) to select a testing phase ; induce vf ; 6 . wait for 5 seconds , if vf is sustained , turn on autopulse ; 7 . at 5 seconds after autopulse is turned on , charge defibrillator , also give 2 manual ventilations ; 8 . at 10 seconds after defibrillator is charged , deliver the test energy in the testing phase ; 9 . if vf is converted , stop autopulse and record delivered joule , impedance and current in data spreadsheet ; if defibrillation fails , continue autopulse , deliver a double energy for rescue shock ; if defibrillation fails again , deliver 200 j for rescue shock . after 5 rescue shocks fail , perform 1 minute autopulse cpr before delivering another round of rescue shocks up to 5 times ; 10 . repeat step 4 and step 9 until all the 5 testing phases are done ; 11 . repeat steps 4 to 10 one more time ; 12 . calculate success probability on the aggregated testing results of the above 2 shocking sequences ; 13 . if the probability & lt ; 50 %, the next test energy was increased by 10 j ; otherwise , decreased by 10 j ; 14 . change defib pads ; 15 . repeat steps 4 to 12 ; 16 . if the probability & lt ; 50 %, the next test energy was increased by 5 j ; otherwise , decreased by 5 j ; 17 . repeat steps 4 to 11 ; 18 . select one from the above 3 used test energies which resulted in a success probability closest to 50 % as the next test energy ; 19 . repeat steps 4 to 10 for 6 times or until the animal is exhausted ; randomization for each block was as follows : for each porcine model , the order of four predetermined coupling phases was randomized using a randomization schedule based on a predetermined random permutation of 4 . a chi square test is then performed on all blocks having an aggregate shock success rate between 40 and 60 percent . it was found that the early decompression phase yielded the best shock success rates , while the early compression phase yielded the least effective shock success rates . it was found that early decompression phase had nearly double the shock success rate of early compression ( 70 . 3 % vs . 36 . 4 %, p = 0 . 0003 , odds ratio ( or )= 4 . 266 , or confidence interval =[ 1 . 916 - 9 . 496 ]). in some implementations , the defibrillator electronics 10 is incorporated directly into the mechanical chest compression device 15 . that configuration has the benefit of reducing the amount of equipment that the rescuer needs to carry to the scene of a cardiac arrest . the battery power supply for the chest compression device then is used for both compressions as well as defibrillation and other physiological monitoring such as pulse oximetry 2 , electrocardiograms 1 , and capnography , which are commonly found in defibrillators . in other implementations , chest compressions 12 may be accomplished by manual compressions . in these implantations , there is no need for a mechanical chest compressor 15 . detection of the exact phase of the compression cycle can be accomplished by a sensor capable of detection of chest compressions 3 . one embodiment is a pressure sensor placed under the patient or under the rescuer &# 39 ; s hands during manual compressions . compression phase detection may also be accomplished by the use of an accelerometer placed beneath the rescuer &# 39 ; s hands during chest compressions as described in u . s . pat . no . 7 , 074 , 199 . edge detection schemes such as bandpass filtering followed by rectification and dynamic thresholding , known to those skilled in the art , can then be performed on the compression signal to determine the start of the decompression phase and then delaying from that point to the optimal timing for initiating delivery of the defibrillation shock . delay from detection of the start of the decompression phase ( diastole ) to initiation of delivery of the defibrillation shock can be as brief as 1 - 2 milliseconds up to only approximately 300 milliseconds ( preferably 125 milliseconds ). to minimize the latency of the phase detection algorithm , zero crossing detection of the raw accelerometer signal is preferably used for compression phase detection . achieving maximal beneficial effect with manual compressions will likely require as short a time as possible for the upstroke phase . duration of the upstroke phase can be minimized by increasing the upstroke velocity of decompressions in the manual compression cycle . to accomplish this both visual and / or verbal prompting is incorporated into the defibrillator to achieve , on a real - time basis , improvement in the upstroke velocity of the rescuer &# 39 ; s compressions . one prohibitive factor with the synchronization of defibrillation to manual compressions is that the defibrillation shock generates approximately 2000 volts . touching the patient directly during a defibrillation shock will not harm the rescuer , but it can generate a significant amount of discomfort . it is thus desirable to incorporate an electrically insulating protection layer that extends over the surface of the patient so that manual compressions may continue safely and unabated during the defibrillation shock , as is described in u . s . pat . no . 6 , 360 , 125 . it is also desirable to synchronize compressions with the electrocardiographic ( ecg ) activity 1 of particularly coarse ventricular fibrillation ( vf ) and to synchronize the defibrillation shock 13 and decompression phase to the maximum positive dv / dt ( informally “ upstroke ”) of the ecg 1 for coarse vf . synchronization of shocks with ecg activity 1 is well know to those skilled in the art , and in particular synchronization to ecg activity 1 of vf has been described in u . s . pat . nos . 6 , 539 , 256 , 6 , 251 , 125 and 6 , 112 , 117 , but none describes the beneficial effect of synchronizing all three elements . coarse vf may be defined simply as vf whose absolute amplitude exceeds some threshold such as 0 . 75 millivolts rms . preferably , however , determination of coarseness may also incorporate such shock prediction measures such as that disclosed in u . s . pat . no . 5 , 957 , 856 to determine whether or not the ecg 1 rhythm and underlying physiological state of the patient is viable enough for delivery of a shock . synchronization of the compression phase with the ecg 1 requires the ability to sufficiently filter out the ecg artifact that results from chest compressions . a preferred implementation of this is described in u . s . pat . no . 7 , 074 , 199 . the mechanical chest compressor can easily synchronize to the ecg activity with such filtering means . delivery of compressions synchronized to ecg activity with manual compressions is not accomplished as easily , but methods exist for providing the appropriate feedback to achieve synchronization of manual compression phase to the ecg activity as described in u . s . pat . no . 7 , 650 , 181 . referring to fig1 , one or more sensors or instruments 1 , 2 , 3 are used to acquire physiological signals from the patient . pre - processing of certain signals may be required to derive relevant measurements or remove artifacts . for example , cpr artifact may be removed from the ecg signal using known techniques . the time of onset ( start ) of a chest compression can be determined in other ways , including from transthoracic impedance , which is typically measured by aeds , or from the artifact generated in the ecg by the chest compression . a speaker 6 generates a feedback tone ( one possible type of feedback cue ), which we also refer to as the compression rate tone ( crt ), at the desired rate and timing with regard to the cardiac cycle . synchronization may be achieved either through direct communication between devices such as an analog signal or a serial universal serial bus ( usb ) interface or synchronization can be achieved wirelessly using a low - latency wireless protocol such as the so - called zigbee , ieee 802 . 15 . 4 protocol standard . pacing may also be combined , in some implementations , with manual compressions as a means of augmenting the rescuer &# 39 ; s mechanical compressions with the electrically - induced contractions of the myocardium . during a resuscitation , the heart is in a state of profound ischemia resulting in a flacidity and loss of tone as lactate builds up in the myocardium and the tissue ph drops . as a result of the loss of tone , the heart becomes a less - effective pump structure for generating blood flow during manual chest compressions . drugs such as epinephrine act to improve tone , but because they are delivered venously , their action may take 2 - 3 minutes during cardiac arrest , when the only blood flow is that induced by the chest compressions . pacing that may or may not be sufficient to actually cause a satisfactory hemodynamic response as a result of the metabolically compromised state of the myocardium can sufficiently improve the tone of the myocardium immediately prior to , and synchronized with , the mechanical compression without the therapeutic delay experienced with drugs such as epinephrine . this instantaneous improvement in myocardial tone can substantially improve the hemodynamic effectiveness of the mechanical compression . in another embodiment , compressions and shock are additionally synchronized and properly phased to the ventilatory cycle . at the time of shock , it is desirable that there not be a ventilation in progress . preferable sequencing is for ventilation expiratory cycle to complete in the decompression phase of the compression cycle immediately proceeding the compression cycle during which the synchronized shock takes place . the ventilator will preferably receive a synchronization signal from defibrillator 10 . many other implementations of the invention other than those described above are within the invention , which is defined by the following claims .
a resuscitation system for use by a rescuer for resuscitating a patient having a ventricular arrhythmia , comprising circuitry and processing configured for detection of chest compression / phase timing information indicative of the start of the decompression phase , circuitry and processing configured for delivery of electromagnetic therapy for the termination of ventricular arrhythmias , wherein the circuitry and processing for the delivery of electromagnetic therapy utilizes the chest compression phase timing information to initiate delivery of the electromagnetic therapy within 300 milliseconds of the start of the decompression phase .