the pumping and aspirating device as seen in fig1 , is an embodiment of the invention delivering a quantitative chronological delivery , including separate claims to be made , with all features being separate and not necessarily included . the cassette device with a plunger , a cylinder area where the reagent is filled , a neck opening in the plunger for the connection of the cartridge to a tube which travels to where the infusion takes place , and the in - line area where probes for sampling are located to provide input to the pumping device are some of the aspects of the invention which provide the unique delivery modalities . there are several means to rotate the plunger in relation to the wall of the cassette . the threaded portion of the cassette requires that the plunger is caused to be rotationally turned as the plunger both infuses and aspirates liquid . an encoded area for the placing of encoded information by bar code , magnetic strip , or other encoding system can be located in the immediate area of the surface which is first to be fitted into the cassette holder ( the “ encoded area ”). a lip cap is provided to cover to protect the cassette from contamination or damage to the plunger , and manually removed when inserting the cassette into the housing . openings along the interior sides of the housing device allow for normally trapped air to be exhausted as the plunger either advances to infuse , or retards to aspirate (“ air space and inspection window ”). the incline planes forming two meshing screw surfaces are positioned so as to allow the plunger to begin turning as it is first attached , and after it is attached to the cassette housing . the plunger can extend beyond the line of the housing for purposes of easy snap - in connection , and alignment of the cassette . the number of turns per meter or inch are adjusted to provide the desired rate of flow in both directions . the diameter of the cassette and its separate housing are adjusted to provide different flow rates , and to adjust for any necessary fluid dynamics which might be necessary to pump highly viscus fluids , or pump fluids at high rates . the housing can either turn or be affixed to the “ pumping device ” with gearing to link the plunger , cassette , or housing to the motor . the motor can be either electromechanical or a manual wind up , spring or band action motor , adjusted by a mechanical timer for the delivery profile . the motor can also be the manual turning by a hand . a second cassette and housing can be coupled and driven either independently or in mechanical linkage with a cassette housing so as to have as many infusion profiles , either in succession or concurrently as is desired for the given flow profiles and applications . on one embodiment , a motor with either electromechanical or mechanical operation such as a spring in mechanical operation , is attached to the gear or drive which in turn causes a rotation of the plunger and both lateral and axial movement of the plunger . the motor is controlled by predetermined settings related to the quantitative chronological profile which uses medical uptake information to determine the pulses best suited for the patient , and which may also be controlled by the desired sensor readings , which can be inputted by the operator to cause the pumping and aspiration actions to take place as desired . in the case of a mechanical motor , the settings can be made by a clock mechanism , with the number of turns and speed of the motor determined by the movement limitations of the terming . the uptake information for this embodiment is used to determine the pulse amount and duration between pluses by taking the clearing rate of uptake for that medication and fixing a time which is before the full clearing time such that the amount of the pulse and the time between pulses is adjusted to achieve maximum change in the momentary presentation to tissue of the medicine , without a significant increase in resulting physiological response . the pumping device can have one , two , three or more sources of input , beginning with the input system to drive the device (“ input ”) the input of sensors for in - line for measurement of substrates (“ in - line sensor probes ”) an in - line occlusion pressure sensing system from the line pressure , or an occlusion sensor from back pressure on the motor , (“ occlusion ”) and / or input from the reading of the encoded area . other traditional pump features are intended to be incorporated into the final pumping device system . fig2 shows the cassette with only one opening , where the plunger also provides the locking connection system to the infusion tube . a standard lure lock attachment , or other quick connection system would be included in the plunger as a single piece . a “ protective cap ” is shown removed from the single piece cassette . splines or grooves on the side of the cassette mesh with a gearing mechanism driven by the motor , all of which are attached to the “ pumping device ” system . the motor rotates the cassette by attachment to splines on the side , with the housing fixed to the pumping device . the plunger then rotates in reference to the cassette , due to the locking of the plunger to the housing by the stanchion . fig3 shows a direct screwing interface to the side of the cassette to accomplish the rotational and axial movement required to provide the delivery profile , as well as a clamshell opening system for easy removal of the cassette and an internal stanchion to hold the plunger which automatically causes the plunger to turn in reference to the cassette as the motor advances the cassette upwards and downwards in order to infuse and aspirate . also shown is a “ rack ” threaded surface which allows the motor , which can be placed adjacent to the rack , to turn the housing , while the plunger remains stationary in relation to the motor and rack , thereby causing the plunger to move rotationally in reference to the cassette . the plunger stanchion can swing away for easy snap - in and snap - out action . in the preferred embodiment , the rotational velocity exceeds the axial velocity , although with sufficient diameter the difference in rotation travel to axial travel could be adjusted for the flow characteristics of the fluid to be infused and aspirated . all housings except as to one version of the rack as shown in fig3 , can be made in a clamshell or disassembled manner for easy withdrawal . the delivery profile is designed to allow increasing or decreasing free levels of medicines by infusion in pulses in accordance with the clearing of the medicine by the patient &# 39 ; s body , so as to allow pulse delivery and an increasing , stable , or decreasing free level of medicine , as determined by the half - life of the medicine or the sensors . the purpose of the preferred embodiment is to provide a system of quantitative chronological delivery a term coined by the inventor . the benefit to having individually delivered pulses of differently spaced and with different amounts of pulse , to respond to changes in the body , such as the amount of glucose in the system . part of the invention claimed is the use of the device in a sequence of infusions which , while in the aggregate the amount of medicine used is less , but by virtue of the pulses , provides bioavailability in dynamic stimulation and accomplishes additional medical results . accordingly , the present invention is a medical infusion and aspiration system delivering quantitative chronological infusions of accurate pulsatile delivery at high rates of flow . another important characteristic of the invention is that the device provides a means to automatically avoid errors in concentration , reagent and medicine type , and avoids the problems of shear and other medicine degrading pressure problems . the system also avoids the slip - stick , chatter , overruns , and the problem of hysteresis by breaking the seating forces between plunger and cassette wall in a lateral motion that does not vary the delivery profile , and overcomes any limitations in the viscosity of the reagent . the system also eliminates the need to dilute reagents to provide additional control for the limitations of accuracy in other systems . other important characteristics of the invention include disposability , inexpensive cost and use by the manufacturer in glass lined or plastic , for the cassette to act as both the pumping cartridge and the shipping and storage cartridge thus avoiding loss of reagent in the priming of an infusion device . the current invention also eliminates the need for withdrawing the medicine with a needle and achieves extraordinary accuracy without error correcting software or expensive volumetric measurement and control systems . the current invention consists of a cassette cartridge pumping and aspirating system . the cassette cartridge contains a plunger , a reservoir area where the reagent is filled , a neck opening for the connection of the plunger or cartridge to a tube which travels to where the infusion takes place , and an in - line sensor area where probes for sampling are located . the in - line area probes are used to provide input to the pumping device . the current invention has only one moving part in relation to the delivery mechanism . simplicity allows for more accuracy and lower costs . it also allows for a single handed adaptation of the cassette to the pumping device , freeing the other hand and avoiding accidental sticking with “ sharps ” such as needles which are contaminated with blood or other materials . in a preferred embodiment , the cartridge is cylindrical in shape and has a reservoir area , and an encoded area . the cartridge may be made of glass , plastic steel or ceramics . it is preferable that part of the outer surface of the cartridge be threaded , and part of the outer surface be grooved to accept and mate with a turning gear . the reservoir area is preferably used for containing a reagent and may be pre - filled , thereby enabling the seller to market pre - filled reagent cartridges . the preferred embodiment eliminates expensive residue that is thrown away with the transportation bottle , as prefilling allows for no waste . pumps which may be re - inserted can store the unused reagent for an appropriate period of time in the cassette . the neck opening , when not contained in the plunger , is preferably located at the bottom surface of the cassette cartridge and sized to connect an infusion tube to the cartridge . any conventional tube connection device may be used to connect the infusion tube to the cartridge . the cartridge also has a cap and container top which protects the plunger and its opening , and allows the cartridge to act as the storage vessel for the reagent , and thereby avoid additional steps of filling , mixing , measuring or wasting reagent in the handling of the fluid . in the preferred embodiment of the invention , an optical or electromagnetic strip is located within an encoded area on the cartridge . when the cartridge is filled , an optical or electromagnetic strip with information on the contents and uses of the reagent is placed in the encoded area . the encoded area is preferably located on the outer surface of the cartridge in the area that is first inserted the housing . when the cartridge is placed in the device , it is preferable that the rotational action causes the encoded area to be well aligned and easily read with the uniform motion of screwing the cartridge into place . the preferred rotation , pre - determined position of the encoded area , and the ease of programming a unique character to each cartridge allows the reagent to be mistake limiting . furthermore , the preferred embodiment system requires the weight of the patient to be entered into the pumping device for each patient , thus greatly reducing the incidence of errors . any conventional method of storing and retrieving data from the encoded area are preferably included in the present system to limit the incidence of errors . it is preferable that the encoded area comes into close proximity with a reading system as the cartridge is loaded or is first used . the reading system may be any commercially available system capable of reading the encoded area . a medical device stores and uses the encoded information in its operations , including a means to limit the profile of the infusion allowed without further intentional override of the profile . in the preferred embodiment , the housing consists of a cylindrical tube that is sealed at the upper end , made from plastic and opens at the bottom end to allow cartridge removal . the inner surface of the housing is preferably threaded and sized to receive the cartridge . a plunger is preferably connected to the sealed end and is suspended in alignment with the central axis of the cylindrical tube by a stanchion . in the preferred embodiment , there is a plurality of openings cut through the housing to allow for normally trapped air to be exhausted as the plunger either advances or retards . the plurality of openings also creates an inspection window within the housing allowing visual access and access to the optical or electromagnetic strip within the encoded area . a lip at the bottom of the housing provides for a manually removable cover used to protect the cartridge from contamination or damage to the plunger . when the cartridge is engaged in the housing , the cartridge is locked into place by the rotational engagement of the threads . the locking of the meshed threads makes an accidental infusion by dropping or pressing on the plunger virtually impossible . the cartridge will not siphon out of the pump , or accidentally deliver fluid when dropped or pushed against , which overcomes a major disadvantage to conventional cartridges or syringes . the preferred plunger is a piston - type plunger and is preferably connected by a stanchion to the sealed end of the housing and is aligned with the central axis of the housing . the plunger head is preferable concaved to trap air and allow for bubble removal , and when an opening is provided on the cartridge , the plunger is sized to fit any reservoir opening , so there is very little dead space thus resulting in very little loss of reagent in the final stroke or at the end of treatment . in the preferred embodiment , a mechanism is used to rotate the plunger within the cassette . the mechanism comprises a gear linkage to the motor , a motor and a gear connection to the cartridge which acts as the pumping device . the pumping mechanism may be actuated by any motor which rotably moves either the plunger or housing , with the other of the two fixed . the present invention allows for direct drive , stepper motor , spring or band action motor , or hand articulation to deliver the desired plunger rotation . the “ motor ” may be even a coordinated hand - eye movement or movement to a series of “ click ” points . in a preferred embodiment , the plunger rotates in relation to the walls of the cartridge . in the preferred embodiment , the cartridge , when placed in the housing , causes the piston plunger to move both forward and aft to infuse or aspirate , and at the same time rotate the plunger within the cartridge to break the forces of inertia and slip - stick as well as eliminate backlash . because the device avoids slip - stick , chatter and the forces of hysteresis , and has no gates or valves , it is designed to also be used in a bi - directional application , such as one of the preferred embodiments herein , where the precise amount being withdrawn may be distributed , equally or in successive steps of precise delivery , or the precise amount withdrawn re - inserted into the patient to the “ zero ” point . a sensor area located in the infusion tube contains probes designed to determine the chemical components and levels of desired substrates in the aspirated fluids . the determination can be by direct measurement of the medicine , or by measurement of the response of the patient to the medicine . the information obtained by the probes relayed to the pumping device and is used to control or limit the infusion profile , including the changing of both the time between pulses and the amount pulsed . the bi - directional accuracy of the present invention allows the system to be used with any number of probes . it is preferable that the probes measure the properties of a sample , such as blood , and then allow the present invention to re - infuse that sample back into the patient after it has been tested , or if necessary , by second valve or gate , deposit that blood into a separate container or depository . the present invention also includes a pumping device to control the cartridge . the pumping device preferably has one , two , three or more sources of input . the preferred pumping device includes , but is not limited to , an input system to drive the device , a sensor input for in - line measurement of substrates , an in - line occlusion pressure sensing system and / or input from the reading of the encoded area , and a means for providing quantitative chronological input . the sensor input receives signals from the in - line sensor probes . the in - line occlusion pressure sensing system determines the line pressure or back pressure on the motor . other traditional pump features are intended to be incorporated into the pumping device . in the preferred embodiment , the rotational velocity exceeds the axial velocity , although with sufficient diameter the difference in rotational travel to axial travel could be adjusted for the flow characteristics of the fluid to be infused and aspirated . it is preferable that a second cassette and housing may be coupled and driven either independently or in mechanical linkage with a cassette housing so as to have as many infusion profiles , either in succession or concurrently as is desired for the given flow profiles and applications . since the cartridge also acts as the pump , each time the cartridge is used , it and preferably the plunger are replaced , and the entire wearing aspects of the pumping system are replaced . the product life cycles are much greater and since the entire fluid handling system is replaced with each use and sterilization and cleaning of parts is eliminated . the purpose of the present invention is to provide a system of quantitative chronological delivery , a term coined by the inventor . the apparent benefit to having individually controlled pulses in duration between pulse , and amount infused , of almost any medicine , as an additional means for stimulating tissue and was deemed by the inventor to be a valid approach to medical infusion for any and perhaps all forms of infusion therapy . part of the invention claimed is the use of the device in sequence of infusions which , while in the aggregate the amount medicine used is less , but by virtue of the pulses , accomplishes additional medical results . a preferred embodiment of the present invention is further described in connection with the accompanying drawings , in which : fig1 is a perspective view of a preferred embodiment of the medical infusion and aspiration system . fig2 is a perspective view of a preferred embodiment of the cartridge . fig3 is a perspective view of a preferred embodiment of the housing and plunger . fig4 is a perspective view of another preferred embodiment of the medical infusion and aspiration device . fig5 is a perspective view of a third preferred embodiment of the medical infusion and aspiration device . fig6 is a perspective view of a fourth preferred embodiment of the medical infusion and aspiration device . fig7 is a perspective view of a fifth preferred embodiment of the medical infusion and aspiration device . fig8 is a perspective view of an embodiment of the medical infusion and aspiration system having two cassettes being driven independently . fig9 is a perspective view of an embodiment of the medical infusion and aspiration system having two cassettes coupled by mechanical linkage . fig1 is a graph of the resulting infusion profile and free levels of medicine when starting with no or low backgrounds of medicines . fig1 is a graph of the resulting infusion profile and free levels of medicine when staring with a prior amount of medicine present in the body . the present invention is a medical infusion and aspiration system capable of accurate pulsatile delivery at high rates of flow adjusting the time between pulses and amount of delivery to provide quantitative chronological delivery . the present invention provides a means to provide changes in timing and amounts of delivery to provide maximum tissue stimulation while automatically avoiding errors in concentration , reagent and medicine type , and avoiding the problems of shear and other medicine degrading pressure problems . the system also avoids the slip - stick , chatter , overruns , and the problem of hysteresis by breaking the seating forces between the plunger and cartridge wall in a lateral motion that does not vary the delivery profile by the viscosity of the reagent . the system also avoids loss of reagent in the priming of a separate infusion device and eliminates the tendency of reagents to separate when in a diluted environment . the invention is disposable , inexpensive and may be used by the manufacturer in glass lined or plastic , as both the pumping cartridge and the shipping and storage cartridge . the current invention , by acting as the storage container , also eliminates the need for withdrawing the medicine from a storage container with a needle and achieves extraordinary accuracy without error correcting software or expensive volumetric measurement and control systems . in general , the current invention comprises quantitative chronological infusion cassette cartridge pumping and aspirating device . the cassette cartridge pumping and aspiration system consisting of a cartridge , a housing , a plunger , a reservoir area where the reagent is contained , a neck opening in the plunger or cassette for the connection of the cartridge to a tube which travels to where the infusion takes place , and an in - line area where probes for sampling are located . the in - line area probes are used to provide input to a pumping device . the current invention has only one moving part in relation to the delivery mechanism and this simplicity allows for more accuracy and lower costs . it also allows for a single handed adaptation of the cartridge to the pumping device , freeing the other hand and avoiding accidental sticking with “ sharps ” such as needles which may be contaminated with blood or other materials . referring now to the figures , fig1 is a perspective view of an embodiment of the invention showing a cassette 10 , a pumping mechanism 20 and a motor 30 . the cassette further comprises a cartridge 12 , and a housing 14 . in a preferred embodiment , as best seen in fig1 and 2 , the cartridge 12 is cylindrical in shape and has a reservoir area 18 , and encoded area 24 . the cartridge 12 is preferably made from glass or plastic . for high - pressure situations , it is preferable that the cartridge 12 be made of steel or ceramics . it is preferable that the outer surface of the cartridge be partially threaded at the top and grooved for the remaining area to the end of the cartridge 26 . any standard or metric thread and groove sizes may be used . the reservoir area 18 is preferably used for containing a reagent . the reservoir area 18 may be pre - filled , thereby enabling the seller to market pre - filled reagent cartridges which also act as the storage and transportation vehicle . the preferred embodiment eliminates expensive residue that is thrown away with a separate transportation bottle , as pre - filing allows for no waste . the preferred embodiment eliminates dilution requirements due to the accuracy of the pumping means . cartridges which may be re - inserted can store the unused reagent for an appropriate period of time in the cartridge . the housing is preferably opened along its center axis to remove cartridges , by means of a hinge 51 which is located off of center to allow the tube to run unobstructed up the stanchion and out of the cassette . the neck opening 22 is preferably located in the plunger 52 , or may be located on the bottom surface of the cartridge 12 . the neck is preferably sized to connect an infusion tube 28 to the cartridge 12 . any conventional tube connection device may be used to connect the infusion tube 28 to the cartridge 12 . the opposite end of the infusion tube 28 is connected to the sensors and then to a vein in the patient 90 . it is preferable that the cartridge 12 also contains a cap as the container top which allows the cartridge 12 to act as the storage vessel for the reagent , and thereby avoids the additional steps of filling , mixing , diluting , measuring or wasting reagent in the handling of the fluid . in the preferred embodiment of the invention , an optical or electromagnetic strip is located within an encoded area 24 on the cartridge 12 . when the cartridge 12 is filled , an optical or electromagnetic strip with information on the contents and uses of the reagent is placed in the encoded area 24 . the encoded area 24 is preferably located on the outer surface of the cartridge 12 in the area that is first inserted the housing 14 . it is preferable that optical reading of a bar code or other reading of the encoded area 24 will minimize dosage mistakes , as each cartridge can set the maximum allowable dose or delivery . when the cartridge : 12 is placed in the system , it is preferable that the rotational action causes the encoded area 24 to be well aligned and easily read with the uniform motion of screwing the cartridge 12 into place . the preferred rotation , pre - determined position of the encoded area 24 , and the ease of programming a unique character to each cartridge 12 allows the reagent to be mistake limiting . furthermore , the preferred embodiment system requires a weight to be entered into a pumping device 40 for each patient , and when computed with the allowable dosing based on weight , greatly reduces the incidence of errors . any conventional method of storing and retrieving data from the encoded area are preferably included in the present system to limit the incidence of errors . it is preferable that the encoded area 24 comes into close proximity with a reading system as the cartridge 12 is loaded or is first used . the reading system may be any commercially available system capable of reading the encoded area 24 . a medical device stores and uses the encoded information in its operations , including a means to limit the profile of the infusion allowed without further intentional override of the profile . in the preferred embodiment , the housing 14 consists of a cylindrical tube that is sealed at the upper end , as shown in fig3 . the housing 14 is preferably made of plastic , however , any suitable commercially available material may be used . the bottom 38 of the housing is preferably open and the inner surface 42 of the housing is threaded . any standard or metric thread size may be used . a plunger stanchion 16 is preferably connected to the sealed end 50 and is suspended in alignment with the central axis 36 of housing 14 . the plunger stanchion is fixed to the housing and is mated with the plunger 52 when the cartridge 12 is inserted into the housing 14 . the plunger 52 is fixed to the stanchion and is not allowed to rotate with the cartridge is turned . the housing 14 is sized to threadedly receive the cartridge 12 . in the preferred embodiment , there is a plurality of openings 44 cut through the housing 14 parallel to the central axis 36 of housing 14 . these openings 44 allow for normally trapped air to be exhausted as the plunger 16 either advances or retards . the plurality of openings 44 also creates an inspection window 46 within the housing 14 . the inspection window 46 also allows access to the optical or electromagnetic strip within the encoded area 24 . a lip 48 at the bottom 38 of the housing 14 provides for a manually removable protective cap like that used for the cartridge 60 used to protect the housing and the cartridge from contamination or damage to the plunger 16 . when the cartridge 12 the plunger 52 engages the stanchion 16 to lock it into place and then when the cartridge is then engaged in the housing 14 , the cartridge 12 is locked into place by the rotational engagement of the threads 26 , 42 . the locking of the meshed threads makes an accidental infusion by dropping or pressing on the plunger virtually impossible . the cartridge 12 will not siphon out of the pump , or accidentally deliver fluid when dropped or pushed against . the preferred plunger 52 is a piston - type plunger and is made from plastic , however , any type of non - reactive material may be used . the plunger 52 is preferably connected to the sealed end 50 of the housing 14 and is aligned with the central axis of the housing . the plunger 52 preferably has a concaved face to allow any air to first fill the neck space and be eliminated when the cartridge 12 , is inserted into the housing 14 , and is preferable sized to fit within the reservoir area 18 , so there is very little dead space thus resulting in very little loss of reagent in the final stroke or at the end of treatment . the plunger 52 and reservoir area 18 configuration may have a larger diameter in relationship to the depth the plunger travels , or a very small diameter and longer plunger travel , depending upon the flow characteristics desired for the application . in very viscous fluids , a different diameter would be helpful for both storage and delivery reasons . in the preferred embodiment , a pumping mechanism 20 is used to rotate the cartridge with the stanchion 16 and the plunger 52 , fixed to the housing 14 . grooves 62 on the side of the cartridge 12 mesh with the gearing mechanism driven by the motor 30 , all of which are attached to the pumping device 40 . the motor 30 rotates the cartridge 12 by attachment to the grooves 62 on the side of the cartridge , with the housing 14 fixed in relation to the motor or pumping device . the pumping mechanism 20 comprises a gear linkage 54 , a motor 30 and a pumping device 40 . the pumping mechanism 20 may be actuated by any motor which rotably moves the stanchion 16 and plunger 52 , or rotates the housing 14 . the present invention allows for direct drive , stepper motor , spring or band action motor , or hand articulation to deliver the desired plunger rotation . the “ motor ” may also be a coordinated hand - eye movement or movement to a series of “ click ” points . in a preferred embodiment , the stanchion 16 and plunger 52 rotate in relation to the walls of the cassette 12 . in one embodiment , a motor 30 with either electromechanical or mechanical operation causes a rotation of the cartridge 12 with the stanchion 16 and plunger 52 fixed to the housing 14 , giving both lateral and axial movement of the stanchion 16 and plunger 52 . the motor 30 is controlled by quantitative chronological input to cause the pumping and aspiration actions to take place as desired to achieve the free medicine profile . in the case of a mechanical motor , the settings may be made by a spring - like mechanism , with the number of turns and speed of the mechanism being governed by a simple clock mechanism . the design of the motor 30 and assembly allow the pump mechanism 20 to be put above , at , or below the heart level , with no resulting change in the delivery profile . this allows the pump mechanism 20 to be worn or enclosed in several different tamper - proof or patient access limiting configurations . the planes formed by the inner surface 42 of the housing and part of the outer surface 26 of the cartridge are positioned so as to allow the cartridge 12 to begin turning as it is first attached , or after the plunger 52 is attached to the stanchion 16 . the stanchion 16 may extend beyond the line of the housing 14 for purposes of easy snap - in connection and alignment of the plunger 52 and also the cartridge 12 . the number of turns per meter or inch are adjusted to provide the desired rate of flow in both directions . the diameter of the cartridge and its separate housing are adjusted to provide different flow rates and to adjust for any necessary fluid dynamics which might be necessary to pump highly viscous liquids or pump fluids at high flow rates . as the cartridge 12 is rotationally turned , the device infuses or aspirates liquid , depending on the rotational direction of rotation . the rotational movement of the present invention allows for bi - directional movement and provides accurate infusion or aspiration . fig4 shows an alternate embodiment of the device . in this embodiment , the cartridge 12 has an opening 22 , where the infusion tube 28 is connected to the cartridge . the plunger 16 then rotates , due to the lands and groves meshed between the housing 14 and cartridge 12 , causing the infusion and aspiration . fig5 shows another embodiment of the present invention . in this embodiment , a direct screwing system 64 interface is attached to the side of the cassette 10 . the direct screwing system 64 accomplishes the rotational and axial movement of the plunger 52 by dual gearing of the internal rotational drive which automatically causes the plunger 16 to turn as the motor advances the plunger 16 downwards and upwards in order to infuse or aspirate . fig6 shows a fourth embodiment of the present invention . fig6 shows a rack 66 threaded surface , which allows the motor 30 , when placed adjacent to the rack 66 , to turn the housing 14 . the plunger 16 remains stationary in relation to the motor 30 and rack 66 , thereby causing the plunger 16 to move rotationally in reference to the cassette 10 . the plunger sanction 68 may swing away for easy snap - in and snap - out action . fig7 shows a fifth preferred embodiment of the present invention . fig7 shows a side screw 82 configuration for the cassette . fig8 and fig9 show multiple cassettes . fig1 shows the infusion profile where the infusion begins with no or little background level of bioavailable medicine and the time between infusion x is maintained or changed y with the concurrent amount of each pulse or bolus changed z . the profile can be changed to provide increased or decreased baselines of free levels of medicines . fig1 shows the infusion profile where the infusion begins with some existing background level of bioavailable medicine and the time between infusion x is maintained or changed y with the concurrent amount of each pulse or bolus changed z in order to give significant stimulation of the tissue . the profile can be changed to provide increased or decreased baselines of free levels of medicines . in the preferred embodiment , the cartridge 12 , when placed in the housing 14 , causes the piston plunger 16 to move both forward and aft to aspirate for testing and then infuse , as well as rotate within the cassette 10 to break the forces of inertia and slip - stick as well as eliminate backlash . the infusion is delivered in pulses where the duration between pulses x is changed y to increase , maintain or decrease the levels of free medicine which causes beneficial responses by tissues to the medicines . because the device avoids slip - stick , chatter and the forces of hysteresis , and has no gates or valves , it is designed to also be used in a bi - directional application , such as one of the preferred embodiments herein , where the precise amount being withdrawn may be tested and then re - inserted into the patient to the “ zero ” point . in the preferred embodiments shown in fig1 , and 5 , a sensor area 70 is located within the infusion tube 28 . the sensor area 70 contains probes 72 designed to determine the chemical components and levels of desired substrates in the aspirated fluids . the information obtained by the probes 72 relayed to the pumping device 40 and is used to control or limit the infusion profile as contained in fig1 and 11 . in prototype construction the probes were made of electromagnetic material , however any probe capable of relaying information to the pumping device may be used , including radio frequency , light , infrared waive forms , and chemical testing which is photo sensitive or reactive to the desired substrates . the bi - directional accuracy of the present invention allows the system to be used with any number of probes . it is preferable that the probes measure the properties of a sample , such as blood , and then allow the present invention to re - infuse that sample back into the patient after it has been tested , or if desired , by second flow direction , deposit that blood into a separate container or depository . referring to fig1 and 5 , the present invention also includes a pumping device 40 . the pumping device 40 preferably has one , two , three or more sources of input and delivers quantitative chronological infusions fig1 and 11 . the preferred pumping device includes , but is not limited to , an input system to drive the device 74 , a sensor input for in - line measurement of substrates 76 , an in - line occlusion pressure sensing system 78 and / or input from the reading of the encoded area 80 . the sensor input 76 receives signals from the in - line sensor probes 72 . the in - line occlusion pressure sensing system 78 determines the line pressure or back pressure on the motor . other traditional pump features are intended to be incorporated into the pumping device 40 . in the preferred embodiment , the rotational velocity exceeds the axial velocity , although with sufficient diameter the difference in rotational travel to axial travel could be adjusted for the flow characteristics of the fluid to be infused and aspirated . it is preferable that a second cassette and housing may be coupled and driven either independently or in mechanical linkage 80 with a cassette housing so as to have as many infusion profiles , either in succession or concurrently as is desired for the given flow profiles and applications , as shown in fig8 and 9 , with flows as shown in fig1 and 11 . it is a desired effect of the present invention that certain deliveries via long catheters positioned in the patient may benefit from a very stable and accurate system which is not subject to the errors of conventional pumps , even when overcoming higher pressures within a given area . since the cartridge and plunger is also the pumping system , each time the cartridge and plunger are used , they are replaced , and the entire wearing aspects of the pumping system are replaced , thereby causing the product life cycles to be much greater . the entire fluid handling system is replaced with each use and sterilization and cleaning of parts is eliminated . the purpose of the present invention is to provide a system of quantitative chronological delivery , a term coined by the inventor . the apparent benefit to having timed pulses of individually controlled amounts , of almost any medicine , as an additional mode for delivery , was deemed by the inventor to be a valid approach to medical infusion for any and perhaps all forms of infusion therapy . part of the invention claimed is the use of the device in sequence of infusions which , while in the aggregate the amount medicine used is less , but by virtue of he pulses , accomplishes additional medical results . the preferred embodiments described herein are illustrative only , and although the examples given include many specificity &# 39 ; s , they are intended as illustrative of only a few possible embodiments of the invention . other embodiments and modifications will , no doubt , occur to those skilled in the art . the examples given should only be interpreted as illustrations of some of the preferred embodiments of the invention , and the full scope of the invention should be determined by the appended claims and their legal equivalents .
the present invention is a medical infusion and aspiration system delivering precisely timed and accurately calculated , adjusted pulsated delivery in high rates of flow delivering an effective profile of pulses tailored to provide momentary spikes of levels of freely available medicines based upon the uptake of the medicine and optimally on real time measurements of the medicine or response of the patient , termed quantitative chronological delivery . the system comprises any pumping mechanism , and optimally a pumping mechanism , and a cassette or cartridge having a reservoir area where the plunger rotates as it advances in reference to the cartridge to provide additional accuracy and overcome the forces of inertia and slip - stick as well as eliminate backlash . optimally , the systems incorporates an encoded area and an opening for connection to an infusion tube with an in - line sensor area where sampling probes are located . the infusion is adjusted in both amount and duration between pulses to provide quantitatively controlled , chronologically optimized infusion . a motor causes bi - directional pumping to allow for samples to be presented to the sensor area . the system accuracy allows for more concentrated medicines , as a sealed container can eliminate the need for diluting or withdrawing medicine to load a reservoir , and achieves extraordinary accuracy without error correcting software or expensive volumetric measurement and control systems .