all parts , percentages and ratios used herein are expressed by weight unless otherwise specified . all publications , patent applications and issued patents mentioned herein are hereby incorporated in their entirety by reference . the present invention relates to any number of treatment agents that are delivered via tablet forms . thus , pharmaceuticals ( medicines , for instance ), nutraceuticals ( vitamins , mineral supplements , and the like ), breath fresheners , tooth cleaners , and the like . the tablets of this invention would include , in addition to the treatment agents noted above , from about 10 % to about 80 % of the low surface area silica ( 60 to 90 m 2 / g , preferably from 65 to 75 m 2 / g ), preferably from about 15 % to about 50 %, about 20 % to 80 % sugar alcohol , preferably about 20 % to about 70 %, and about 1 % to about 30 % of a super disintegrant , preferably about 3 % to about 15 %, more preferably about 3 % to 5 %. the low surface area silica component of the inventive tablet substrate is preferably a calcined amorphous precipitated silica exhibiting a surface area from 60 to 90 m 2 / g , preferably from 65 to 75 m 2 / g . the silica material is calcined in order to provide the low surface area required to provide the quick disintegration properties of the inventive tablets . possible pre - calcined precipitated silicas include the following products available from the j . m . huber corporation , edison , n . j . : zeo ® 49 , zeofree ® 153 , zeothix ® 265 , zeothix 95 , and zeothix 177 , zeodent ® v 103 , zeodent t 113 , zeodent ® 114 , zeodent ® 115 , zeodent ® i 118 , zeodent ® 119 , zeodent (® 165 , and zeodent ® 9175 . silicas suitable for use in the present invention , as well as processes suitable for preparing them , are set forth in u . s . pat . nos . 3 , 893 , 340 , 4 , 340 , 583 , 5 , 225 , 177 , and 6 , 616 , 916 , as well as u . s . patent publication no . 2003 / 0131536 a1 . additionally , precipitated amorphous silicas are available from ineos silicas , warrington , england , marketed under sorbosil ; from rhodia silica systems , lyon , france , marketed under tixosil ® and oralsil ® and from degussa ag , germany marketed under sident . the most preferred silica material is zeodent 165 , which exhibits a surface area of about 71 m 2 / g after calcinations for 2 hours at 900 ° c . in addition to precipitated silica , the silica may also be selected from ( without intending to be limiting ) amorphous silicas such as silica gel , and pyrogenic silica ( i . e ., fumed silica )( both types which would require calcinations to attain the low surface area required as above , and thus heated to 900 ° c . for 2 hours ). suitable pyrogenic silicas include aerosil ® products available from the degussa ag , germany ; and cab - o - sil ® products available from cabot corporation , bellerica , mass .. suitable silica gels include silcron ® products available from millennium inorganic chemicals corporation , baltimore md . ; and syloid ®, sylodent ®, syloblanc ® and sylox ® products available from grace & amp ; co ., davison chemical division , baltimore , md . the sugar alcohol provides multiple functions to the rapidly disintegrating tablet . the sugar alcohol provides good aesthetic properties to the dissolved oral care tablet such as taste and “ mouth texture ” or body ; aids in rapid tablet disintegration ; and serves as a tablet filler . suitable sugar alcohols include glycerin ( glycerol ), erythritol , xylitol , sorbitol , maltitol , mannitol , lactitol , and the like , used singly and in combinations , with mannitol and sorbitol preferred . the super disintegrant facilitates the break - up of a tablet when it is placed in an aqueous environment , such as the mouth . super disintegrants in contact with water swell , wick - in water or otherwise provide a disruptive force to a tablet causing it to break apart . suitable super disintegrants include one or more of sodium starch glycolate , available as e . g . explotab and explosol ; croscarmellose sodium ( cross - linked sodium carboxymethyl cellulose ) available as e . g . ac - di - sol ( and nymcel ® zsx ; and cross - linked polyvinylpyrolidones available as e . g . polyplasdone xl . in addition to the aforementioned ingredients , the tablet products of the present invention may also include several other ingredients such as additional disintegration aids , organoleptic enhancers , additional abrasives , thickening agents , ( also sometimes known as thickeners , binders , gums , or stabilizing agents ), therapeutic agents , and preservatives . these solid formed tablet preparations may also include one or more disintegration aids , in addition to the super disintegrant . suitable disintegration aids include natural , modified or pregelatinized starch ; natural or chemically - modified cellulose ; microcrystalline cellulose ; gum , especially agar gum , and guar gum ; alginic acid or salts thereof ; acetates and citrates ; sugars ( especially sucrose , amylose , dextrose and lactose ); aluminum oxide ; synthetic polymers such as methacrylic acid - divinylbenzene copolymer , as well as effervescent disintegrating systems . typical levels of disintegration aids in the inventive tablet preparations are from about 0 . 5 % to about 15 % of the formulation , preferably from about 1 % to about 5 %. the inventive tablet compositions may also contain one or more organoleptic enhancing agents . organoleptic enhancing agents include humectants , sweeteners , surfactants , flavorants , colorants and effervescing agents . humectants serve to add body or “ mouth texture ” to a tablet . in addition to the previously mentioned sugar alcohols , suitable humectants include glycerin , polyethylene glycol ( at a variety of different molecular weights ), propylene glycol , and hydrogenated starch hydrolyzates , as well as mixtures of these compounds . sweeteners may be added to the tablet composition to impart a pleasing taste to the product . suitable sweeteners include saccharin ( as sodium , potassium or calcium saccharin ), cyclamate ( as a sodium , potassium or calcium salt ), aspartame , acesulfane - k , thaumatin , neohisperidin dihydrochalcone , ammoniated glycyrrhizin , dextrose , maltodextrin , sucralose , fructose , levulose , sucrose , mannose , and glucose . typical levels of sweeteners are from about 0 % to about 5 % of a tablet composition . surfactants are used in the compositions of the present invention to make the compositions more cosmetically acceptable . the surfactant is preferably a detersive material which imparts to the composition detersive and foaming properties . suitable surfactants are safe and effective amounts of anionic , cationic , nonionic , zwitterionic , amphoteric and betaine surfactants such as sodium lauryl sulfate , sodium dodecyl benzene sulfonate , alkali metal or ammonium salts of lauroyl sarcosinate , myristoyl sarcosinate , palmitoyl sarcosinate , stearoyl sarcosinate and oleoyl sarcosinate ,, polyoxyethylene sorbitan monostearate , isostearate and laurate , sodium lauryl sulfoacetate , n - lauroyl sarcosine , the sodium , potassium , and ethanolamine salts of n - lauroyl , n - myristoyl , or n - palmitoyl sarcosine , polyethylene oxide condensates of alkyl phenols , cocoamidopropyl betaine , lauramidopropyl betaine , palmityl betaine and the like . sodium lauryl sulfate is a preferred surfactant . the surfactant is typically present in the tablet compositions of the present invention in an amount of about 0 . 1 to about 15 % by weight , preferably about 0 . 3 % to about 5 % by weight , such as from about 0 . 3 % to about 2 %, by weight . flavoring agents optionally can be added to tablet compositions . suitable flavoring agents include , but are not limited to , oil of wintergreen , oil of peppermint , oil of spearmint , oil of sassafras , and oil of clove , cinnamon , anethole , menthol , thymol , eugenol , eucalyptol , lemon , orange and other such flavor compounds to add fruit notes , spice notes , etc . these flavoring agents consist chemically of mixtures of aldehydes , ketones , esters , phenols , acids , and aliphatic , aromatic and other alcohols . colorants may be added to improve the aesthetic appearance of the tablet product . suitable colorants are selected from colorants approved by appropriate regulatory bodies such as the fda and those listed in the european food and pharmaceutical directives and include pigments , such as tio 2 , and colors such as fd & amp ; c and d & amp ; c dyes . the tablet product may also contain an effervescent agent to provide aesthetic properties to the tablet . preferably effervescence is provided by reaction of a carbonate salt such as calcium carbonate , sodium carbonate , sodium bicarbonate , potassium carbonate or potassium bicarbonate with an acid such as citric acid , tartaric acid or malic acid . thickening agents are useful in the tablet products of the present invention to provide an aesthetically pleasing texture when the composition disintegrates in the mouth . suitable thickening agents include silica thickeners such as j . m . huber corporation zeodent ® precipitated silica products and silica gels available from davison chemical division of w . r . grace corporation , baltimore , md . ; natural and synthetic clays such as hectorite clays ; lithium magnesium silicate ( laponite ) and magnesium aluminum silicate ( veegum ); starch ; glycerite of starch ; as well as mixtures of these compounds . typical levels of thickening agents are from about 0 % to about 15 % of an oral care composition . the tablet will contain at least one treatment agent selected from pharmaceutical actives , nutraceutical actives , and oral care actives . pharmaceutical actives will impart medicinal treatments to a user through ingestion in the mouth . the active substances which can be used according to the invention may be selected without limitation among those belonging to the following groups : analgesic drugs such as , e . g ., buprenorphine , codeine , fentanyl , morphine , hydromorphone , and the like ; anti - inflammatory drugs such as , e . g ., ibuprofen , indomethacin , naproxen , diclofenac , tolfenamic acid , piroxicam , and the like ; anthelmintics such as albendazole , flubendazole , ivermectin , diethylcarbamazine citrate and the like . antibacterials such as aminoglycosides ( kanamycin , neomycin , and the like ), rifampin , cephalosporins and related beta lactams ( cefazolin , cefuroxime , cefaclor and the like ), glycopeptides ( vancomycin and the like ), penicillins ( amoxicillin , ampicillin , carbenecillin , cloxacillin , dicloxacillin , and the like ), quinolones ( gatifloxcin , ciprofloxacin and the like ), sulfonamides ( sulfadiazine , sulfamethoxazole , sulfamerazine , trimethoprim , sulfanilamide , and the like ), tranquilizers such as , e . g ., diazepam , droperiodol , fluspirilene , haloperidol , lorazepam , and the like ; cardiac glycosides such as , e . g ., digoxin , ouabain , and the like ; antiparkinson agents such as , e . g ., bromocriptine , biperidin , benzhexol , benztropine , and the like ; antidepressants such as , e . g ., imipramine , nortriptyline , pritiptylene , lithium carbonate , clozapine , citalopram , fluoxeitine and the like ; antineoplastic agents and immunosuppressants such as , e . g ., cyclosporin a , fluorouracil , mercaptopurine , methotrexate , mitomycin , and the like ; antiviral agents such as , e . g ., idoxuridine , acyclovir , vidarabin , and the like ; antibiotic agents such as , e . g ., clindamycin , erythromycin , fusidic acid , gentamicin , and the like ; antifungal agents such as , e . g ., miconazole , ketoconazole , clotrimazole , amphotericin b , nystatin , and the like ; antimicrobial agents such as , e . g ., metronidazole , tetracyclines , and the like ; appetite suppressants such as , e . g ., fenfluramine , mazindol , phentermin , and the like ; antiemetics such as , e . g ., metoclopramide , droperidol , haloperidol , promethazine , and the like ; antihistamines such as , e . g ., chlorpheniramine , chlorpheniramine maleate , terfenadine , triprolidine , and the like ; antimigraine agents such as , e . g ., dihydroergotamine , ergotamine , pizotyline , and the like ; coronary , cerebral or peripheral vasodilators such as , e . g ., nifedipine , diltiazem , and the like ; antianginals such as , e . g ., glyceryl nitrate , isosorbide dinitrate , molsidomine , verapamil , and the like ; calcium channel blockers such as , e . g ., verapamil , nifedipine , diltiazem , nicardipine , and the like ; hormonal agents such as , e . g ., estradiol , estron , estriol , polyestradiol , polyestriol , dienestrol , diethylstilbestrol , progesterone , dihyroergosterone , cyproterone , danazol , testosterone , and the like ; contraceptive agents such as , e . g ., ethinyl estradiol , lynestrenol , etynodiol , norethisterone , mestranol , norgestrel , levonorgestrel , desogestrel , edroxyprogesterone , and the like ; antithrombotic agents such as , e . g ., warfarin , and the like ; diuretics such as , e . g ., hydrochlorothiazide , flunarizine , minoxidil , and the like ; antihypertensive agents such as , e . g ., propanolol , metoprolol such as metoprolol tartrate or metoprolol succinate , clonidine , pindolol , and the like ; chemical dependency drugs such as , e . g ., nicotine , methadone , and the like ; local anesthetics such as , e . g ., prilocaine , benzocaine , and the like ; corticosteroids such as , e . g ., beclomethasone , betamethasone , clobetasol , desonide , desoxymethasone , dexamethasone , diflucortolone , flumethasone , fluocinolone acetonide , fluocinonide , hydrocortisone , ethylprednisolone , triamcinolone acetonide , budesonide , halcinonide , and the like ; dermatological agents such as , e . g ., nitrofurantoin , dithranol , clioquinol , hydroxyquinoline , isotretionin , methoxsalen , methotrexate , tretionin , trioxsalen , salicylic acid , penicillamine , and the like ; steroids such as , e . g ., estradiol , progesterone , norethindrone , levonorgestrol , ethynodiol , levenorgestrel , norgestimate , gestanin , desogestrel , 3 - keton - desogestrel , demegestone , promethoestrol , testosterone , spironolactone , and esters thereof , azole derivatives such as , e . g ., imidazoles and mazoles and derivatives thereof , nitro compounds such as , e . g ., amyl nitrates , nitroglycerine and isosorbide nitrates , amine compounds such as , e . g ., pilocaine , oxyabutyninchloride , benzocaine , nicotine , chlorpheniramine , terfenadine , triprolidine , propanolol , metoprolol and salts thereof , oxicam derivatives such as , e . g ., piroxicam , mucopolysaccharides such as , e . g ., thiomucasee , opoid compounds such as , e . g ., morphine and morphine - like drugs such as buprenorphine , oxymorphone , hydromorphone , levorphanol , hydrocodone , hydrocodone bitratrate , fentanyl and fentany derivatives and analogues , prostaglandins such as , e . g ., a member of the pga , pgb , pge , or pgf series such as , e . g ., misoprostol or enaprostil , a benzamide such as , e . g ., metoclopramide , scopolamine , a peptide such as calcitonin , serratiopeptidase , superoxide dismutase ( sod ), tryrotropin releasing hormone ( trh ), growth hormone releasing hormone ( ghrh ), and the like , a xanthine such as , e . g ., caffeine , theophylline , a catecholamine such as , e . g ., ephedrine , salbutamol , terbutaline , a dihydropyridine such as , e . g ., nifedipine , a thiazide such as , e . g ., hydrochlorotiazide , flunarizine , a sydnonimine such as , e . g ., molsidomine , and a sulfated polysaccharide , as well as cholesterol - lowering statin drugs , such as atorvastatin , simvastatin , and the like . the active substances mentioned above are also listed for illustrative purposes ; the invention is applicable to any pharmaceutical formulation regardless of the active substance or substances incorporated therein . they can be present in any amount , but preferably from 0 . 01 to about 30 % by weight therein . typical nutraceutical actives include vitamins ( any of the typical ones , such as vitamins a , b 6 , b 12 , c , d , and k ) as well as mineral supplements ( calcium carbonate , calcium phosphate , and other types of compounds that deliver desirable doses of calcium , magnesium , and other like minerals to a user ). the same proportion of nutraceutical active as for the pharmaceutical types may be present . typical oral care actives include abrasives . suitable abrasives include precipitated and ground calcium carbonate , calcium metasilicate , calcium pyrophosphate , dicalcium phosphate , dicalcium phosphate dihydrate , aluminum silicate , alumina , calcined alumina , bentonite , particulate thermosetting resins and other suitable abrasive materials known to a person of ordinary skill in the art . the abrasive may be used alone or in combination with other abrasives . typical levels of abrasives in the inventive dentifrice formulation are from about 2 % to about 60 %, preferably from about 2 % to about 10 %. further oral care actives include various therapeutic agents for the prevention and treatment of dental caries , periodontal disease and temperature sensitivity . examples of therapeutic agents , without intending to be limiting , are fluoride sources , such as sodium fluoride , sodium monofluorophosphate , stannous fluoride , potassium fluoride , sodium fluorosilicate , ammonium fluorosilicate and the like ; condensed phosphates such as tripolyphosphates , hexametaphosphates , trimetaphosphates and pyrophosphates ; antimicrobial agents such as triclosan , bisguanides , such as alexidine , chlorhexidine and chlorhexidine gluconate ; enzymes such as papain , bromelain , glucoamylase , amylase , dextranase , mutanase , lipases , pectinase , tannase , and proteases ; quartemary ammonium compounds , such as benzalkonium chloride ( bzk ), benzethonium chloride ( bzt ), cetylpyridinium chloride ( cpc ), and domiphen bromide ; metal salts , such as zinc citrate , zinc chloride , and stannous fluoride ; sanguinaria extract and sanguinarine ; volatile oils , such as eucalyptol , menthol , thymol , and methyl salicylate ; amine fluorides ; peroxides and the like . therapeutic agents may be used in dentifrice formulations singly or in combination at a therapeutically safe and effective level . preservatives may be also be optionally added to the compositions of the present invention to prevent bacterial growth . suitable preservatives approved for use in oral compositions such as methylparaben , propylparaben and sodium benzoate may be added in safe and effective amounts . the tablet products may additionally contain other optional ingredients typically used in tablet making such as glidants to provide even flow to the granulation to be tabletted , e . g . amorphous silica such as zeopharm ® 80 ( j . m . huber corporation , edison , n . j .) and cab - o - sil ® m5 ( cabot corporation , billerica , mass . ); die release aids , also known as lubricants , such as magnesium stearate ( available as hyqual ® nf from mallinckrodt , inc ., st . louis , mo .) to enable tablets to be released from within the tablet machine die , anti - adherents , such as stearic acid , to facilitate separation of tablets from punch faces ; and fillers such as microcrystalline cellulose , such as avicel 101 ( fmc biopolymers , philadelphia , pa .) and omnicel 102 ( functional foods , englishtown , n . j .). all tablet formulation ingredients , except the lubricant , are weighed together and mixed . thereafter , the lubricant is geometrically diluted with the just prepared tablet mixture and then added back to the mixture . this step is typically necessary to homogeneously incorporate the hydrophobic lubricant into the tablet mixture . the tablets are then manufactured by using a tableting compacting process . a standard single stroke or a rotary press may be used . the tablets prepared according to this invention may be of any geometrical shape , such as round , square , triangular , or caplet - shaped , and of any size suitable for human or animal use . the invention will now be described in more detail with respect to the following , specific , non - limiting examples . tablets were prepared by weighing all formulation ingredients together , except the lubricant magnesium stearate , on a weighing pan . typically , a tablet formulation was 300 g to 500 g total weight , in order to prepare multiple tablets for testing . the combined ingredients were passed through a 20 mesh ( 850 μm ) sieve to remove any lumps and then bag blended , by gentle inversion in a plastic bag for about 30 seconds of the formulation ingredients previously weighed . the resulting mixture was transferred to a pk - v blender ( twin shell dry blender model 014 - 215 - 0053 , available from patterson kelly , east stroudsburg , pa .) and mixed for 10 minutes . the magnesium stearate lubricant was then geometrically diluted with the mixture and then added back to the pk blender and all ingredients mixed together for an additional 5 minutes . tablets were formed from the resulting formulation on a 8 - station piccola rotary tablet press available from riva s . a ., argentina , fitted with 10 mm standard concave die punches compacting over a range of compression forces , expressed in kn . tablet weight was set at 400 mg by adjusting the tablet press . excipient grade company calcined zeodent ® 113 j . m . huber corp ., edison , nj precipitated silica zeodent ® 119 zeodent ® 165 zeodent ® 9175 calcined silica sylodent ® 756 grace davison , baltimore , md gel mannitol pearlitol ® 200sd roquette freres , lestrem , france compressible nu - tab ® 4000 chr hansen , vineland , nj sugar crospovidone polyplasdone ® xl - international specialty products , wayne , nj 10 sodium starch explotab ® penwest pharmaceuticals co ., patterson , ny glycolate ( ssg ) microcrystalline omnicel ® 102 functional foods , englishtown , nj cellulose ( mcc ) microcrystalline avicel ® 101 fmc biopolymer , philadelphia , pa cellulose ( mcc ) sodium lauryl aceto corporation , lake success , ny sulfate fumed silica cab - o - sil ® m5 cabot corporation , bellerica , ma glidant magnesium hyqual ® nf mallinckrodt , inc ., st . louis , mo stearate all tablets were prepared 24 hours before testing hardness , disintegration time and friability . tablet hardness ( h ) expressed in kp , for each formulation , was measured on 5 tablets utilizing a erweka tbh30 instrument ( milford , conn .) and the result reported was an average of 5 measurements . tablet disintegration time was determined by placing 6 tablets ( each tablet in a separate tube ) in an erweka zt72 disintegrator ( milford , conn .). the tablets were repeatedly immersed in 37 ° c . deionized water at a rate of 30 strokes / min . until the tablets disintegrated , as detected and recorded by the instrument . the reported result was an average of the 6 measurements . tablet friability was determined by placing 10 tablets in a distek , inc . friabilator df - 3 ( north brunswick , n . j .) set for 100 revolutions . the % friability is calculated from the amount of tablet weight lost ( friable ) by weighing the tablets before and after rotation . in theses examples , oral care tablet formulations were made with low surface area silica , a super disintegrant , a sugar alcohol and other ingredients typically found in oral care formulations and in tablet formulations . these formulations were prepared according to the procedure described above with the amounts of ingredients identified in table 1 . all of the zeodent products below have been calcined to attain the low surface area needed of the silica material . tablets weighing 400 mg each were prepared according to the procedure described above . each formulation was compressed into tablets at different compression forces for each respective formulation . the tablet hardness ( h ), disintegration time ( dt ) and were determined according to the procedures described above for tablets different compression forces with the results summarized in table 2 below . it is seen from the data in table 2 above that all of these tablet formulations could be compressed into non - friable tablets with disintegration times of about 10 seconds . generally , tablets with a friability of greater than i % either were not compressed with enough force for the tablet to remain intact or the tablets capped . example 2 which containe 10 % silica , about 63 % mannitol and 20 % mcc was only compressed into tablets at one compression force , since the tablet ejection force exceeded 1000n . for comparison , tablet formulations were prepared as described above , but each formulation was missing an essential ingredient selected from a sugar alcohol , a super disintegrant and silica . for instance , comparative example 1 ( cl ) contained silica and a super disintegrant , but compressible sugar instead of a sugar alcohol . comparative example 2 ( c2 ) contained silica and the sugar alcohol mannitol , but no super disintegrant . comparative example 3 ( c3 ) contained a sugar alcohol and a super disintegrant , but no silica . the formulations are summarized in table 3 below . each formulation was compressed into tablets at different compression forces for each respective formulation . comparative examples 1 and 2 tablets were prepared as described above . for comparative example 3 formulation , 500 mg tablets were made by direct compression in an angstrom pellet press at forces of 3 . 6 , 4 . 4 , and 8 . 9 kn . the angstrom press mould had a circular shape and a diameter of 1 . 4 cm . for comparative examples 1 and 2 , the tablet hardness , disintegration time ( dt ) and % friability were determined according to the procedures described above for tablets pressed at different compression forces . since comparative example 3 tablets were prepared manually , only disintegration time was determined . comparative example 3 tablets were immersed in deionized water at 37 ° c . and the time ( seconds ) required for initial fracture of the tablet was recorded for disintegration time . results for all three comparative examples are summarized in table 4 below . it is seen from the above data that tablets without silica ( c3 ) and without a super disintegrant ( c2 ) had longer disintegration times than tablets of comparable hardness made according to the present invention . the tablets made with compressible sugar instead of the sugar alcohol all capped yielding very high friability . oral care tablets were formed as in example ii of wo 99 / 33437 without the non - essential ingredients : color , sodium fluoride , cetyl pyridinium chloride and flavor . since this patent application was silent as to the compression forces used to form the tablets , several different compression forces were used for tablet formation . since this formulation would not flow evenly to feed an automatic tableting press , tablets were formed by manually pressing the resulting mixture in an angstrom press fitted with a 13 - mm diameter die at 2000 psi , 1000 psi and 500 psi . the formulation ingredient amounts are given below in table 5 . example ii of w099 / 33437 is reproduced herein as comparative example 4 ( c4 ). disintegration time was determined on comparative example 4 , compressed at 500 psi . disintegration time was determined by placing 3 tablets in separate tubes in an erweka zt72 disintegrator . the tablets were repeatedly immersed in 37 ° c . deionized water at a rate of 30 strokes per minute until the tablets disintegrated , as detected and recorded by the instrument . these c4 tablets had a hardness of 2 . 2 kp and a disintegration time of over 9 minutes . it will be appreciated by those skilled in the art that changes could be made to the embodiments described above without departing from the broad inventive concept thereof . it is understood , therefore , that this invention is not limited to the particular embodiments disclosed , but it is intended to cover modifications within the spirit and scope of the present invention as defined by the appended claims .
this invention pertains to the ability to provide rapidly disintegrating tablets through the inclusion of a silica material in combination with other common tablet components . such a silica material must exhibit a sufficiently low surface area in order to boost the ability of the table to separate quickly when introduced into a user &# 39 ; s mouth cavity . such a tablet is dimensionally stable prior to use and , when immersed in water the tablet disintegrates therein in less than about 60 seconds .