fig1 shows a possible embodiment of the degassing device as proposed in the present disclosure . as shown in fig1 , a liquid , particularly blood enters the degassing device 10 tangentially through an inlet 11 which is located at a bottom 12 of a chamber 13 of the degassing device 10 . the flow of the entered liquid is forced by a spiral shaped wall 14 inside the degassing device 10 into a spiral flow as shown by an arrow 15 . on the way through the degassing device 10 gas bubbles inside the liquid stream have time to rise upwards as indicated by arrows 16 . to guarantee this upwards movement of the gas bubbles , the degassing device 10 has to be placed essentially horizontally , i . e . the spiral wall 14 must be placed essentially vertically . after having passed the chamber 13 in a spiral flow the gas free liquid stream can leave the degassing device 10 through an opening in the bottom 12 of the chamber 13 as shown by arrow 17 . fig2 shows a top view of another embodiment of the proposed degassing device . fig2 clearly shows that the distance between an inner wall 18 of the degassing device 10 and a spiral wall 14 inside the degassing device 10 may be equal to the distance of an outer channel 19 which is generated by the spiral wall . fig3 shows a further possible embodiment of the proposed degassing device with an integrally moulded inlet 11 . the inlet 11 of the degassing device 10 may be variously configured . it is , however , important that the inlet 11 is as close as possible to a bottom wall 12 of a chamber 13 of the degassing device 10 in order to reduce the velocity of the flow beneath a hydrophobic membrane which is to be provided according to the present disclosure . as shown in fig3 , the inlet passage may be horizontal and open through a side wall of the body of the housing in a direction tangential to the side wall . the inlet 11 may further be moulded integrally with the body of the chamber 13 and configured to receive the end of a tube . fig4 shows a further embodiment of the proposed degassing device . fig4 a displays an aerial view of a cover , the cover having a cylindrical configuration and includes , as shown in fig4 a , a generally flat top wall and a down turned , generally cylindrical side wall . fig4 b displays an interior view including a hydrophobic membrane . fig4 c shows a housing of the proposed degassing device including a spiral body and the cover . the cover can have , as shown in fig4 , at least one opening which allows gas which leaves the chamber through the hydrophobic membrane to pass through that opening . in general , it might be sufficient to have a single opening , such as for example in the central part of the cover . fig5 shows a further possible degassing device which is positioned within a standard dialysis setup on the venous or the arterial side . such a setup may comprise a pressure sensor 1 , a first air bubble counter 2 , a pump 3 , a degassing device a , a dialyzer 4 , optionally a second degassing device b , a second pressure sensor 5 and a second air bubble counter 6 . in one embodiment , the degassing device is positioned on the arterial side of the system , i . e . before the dialyzer in order to effectively remove any air which may be present in the system before such air enters the dialyzer ( fig5 , degassing device a ). in this setup , the pump should be located before the degassing device as any device located before the degassing device may cause an air - in - blood - alarm . the setup should further comprise an air bubble counter on the arterial side for detecting air in the system . optionally , a second degassing device may be located on the venous side after the dialyzer as a safety measure ( fig5 , degassing device b ). such a second degassing device may then remove any remaining air bubbles which have passed or been generated during the passage of the dialyzer . in another embodiment , the dialysis setup having an arterial degassing device and an optional second venous degassing device comprises an air bubble counter located before the pressure sensor . in still another embodiment , if a degassing device is mounted in the set which is optimized for a certain flow , such as , for example 350 ml / min or less , it might prove advantageous to reduce the blood flow appropriately . the pump may automatically decrease the blood flow in case of an air - in - blood - alarm to a flow below the optimum of the degassing device . fig6 to 11 are described in connection with the following described examples . the spiral degassing device according to the present disclosure shows an exceedingly well performance with regard to degassing of a liquid , especially of blood , both in in vitro and in in vivo tests . in an in vitro test with bovine blood ( hematocrit between 32 and 40 , total protein content : 60 - 80 g / l ) the efficacy of the degassing device according to the present disclosure was tested by injecting air into the corresponding system ( fig6 ). the setup essentially consisted of a circular flow of blood , comprising one liter of blood ( bovine blood ) at a temperature of 37 ° c ., a pressure manometer , a degassing device according to the present disclosure , a dialyzer ( polyflux ® 170 h , gambro ), a drip chamber and the corresponding tubing . further , the system comprised a first air injection port s 1 and a second air injection port s 2 , with the first air injection port s 1 being located before and the second air injection port s 2 being located after the pressure manometer . the amount or volume of air which left the degassing device was determined by measuring the amount of water which was eliminated from a tube containing water and into which the air coming from the degassing device was introduced . the amount of air introduced into the system via the injection ports can of course be varied . the air injection can be done in a continuous fashion or as a bolus . the flow was adjusted to q b = 300 ml / min , the venous pressure was adjusted to 100 mmhg . the degassing device used had an inner diameter of 32 mm and a spiral height of 17 mm over the total length of the spiral . the spiral had a rotation of 1 . 6 . the distance of the membrane from the upper rim of the spiral was 1 . 5 mm . the membrane was a mmt - 323 ( 0 . 2 μm ) ptfe membrane from gore medical membranes , coated with a solution comprising 5 % antifoam a ® and 95 % of hexane as solvent . fig7 shows the removal of a bolus of 10 ml , injected at injection port s 1 , i . e . on the arterial side of the system . the injected air is completely removed from the system , no air remains in the system or the degassing device either as bubbles in the fluid or as an air cushion . the degassing is achieved within a very short period of time , i . e . within seconds . controls with saline instead of blood showed that there is virtually no difference between the degassing of the liquids , i . e . blood is degassed as good as the significantly less complex saline liquid . fig8 shows the removal of a continuous injection of 10 ml / min of air at injection port s 1 ( arterial side ), about 4 . 5 hours after the test had been started . as can be seen , the air was removed from the system as fast as it was introduced into the system , i . e . with a velocity of 10 ml / min , resulting in a straight slope . this test also shows that the proposed degassing device is able to provide for highly improved degassing efficiency . for comparison , fig9 b shows the degassing profile of a standard degassing device . a bolus of 2 ml was injected at injection port s 1 ( arterial side ). as can be deduced from the drawing , 1 . 5 min are needed for removing 1 . 8 ml of the injected air . the proposed degassing device under the same conditions removes a 2 ml bolus in about 0 . 5 min ( fig9 a ). the same degassing device as described in context of example 1 . above was used also for in vivo tests with sheep , based on a standard dialysis setup including an ak 200 ultra dialysis machine and a polyflux ® 170 h dialyzer ( fig1 ). the system had again injection ports s 1 to s 4 as shown in fig1 , positioned on the arterial or the venous side of the dialyzer . the system further included two degassing devices according to the present disclosure ( see example 1 .) which were positioned before ( arterial side ) and after ( venous side ) the dialyzer , respectively . after the priming of the system the dialysis was performed at a venous pressure of 100 mmhg . the q b was 300 ml / min . a first air injection ( 2 ml bolus ) was performed 20 min after the start of the priming , a second air injection ( 2 ml bolus ) was performed 65 min after the start . a third air injection ( 5 ml bolus ) was performed after 125 min , a fourth air injection ( continuous boli of 1 , 2 , 5 and 10 ml / min ) after 185 min . a fifth and last bolus of 10 ml air was injected after 205 min . fig1 exemplarily shows the profile for the fourth air injection , including four consecutive continuous injections of 1 , 2 , 5 and 10 ml / min ( 4 ), and the profile for the fifth bolus of 10 ml after almost 3 . 5 hours ( 5 ). the profile on the left displays a control injection directly before the degassing device measuring the air which is removed . the table above shows the results of the in vivo test in terms of air which could be detected via the air bubble counter ( abc ) after a given time after the injection . further air injection tests were done in this setup , i . e . injection of air before and after the dialyzer ( s 3 and s 4 ), which air was then removed by the degassing device on the venous side . these results were compared to the degassing efficiency in cases where the air injection was done at s 1 and s 2 and removed from the system by the degassing device on the arterial side of the system . as various changes could be made in the above constructions without departing from the scope of the present disclosure , it is intended that all matter contained in the above description or shown in the accompanying drawings shall be interpreted as illustrative and not limiting .
a device for degassing gas bubbles out of a liquid comprises a housing having a liquid inlet , a liquid outlet and a gas bubble outlet . the housing includes a spiral wall defining a spiral flow path for the liquid and a hydrophobic membrane above the spiral wall and between the spiral wall and the gas bubble outlet . the spiral wall forces inward liquid entering the housing through the inlet into a spiral flow along the spiral flow path , and causes an upward flow of the gas bubbles toward the hydrophobic membrane . a method for degassing gas bubbles out of a liquid , e . g ., blood , e . g ., during hemodialysis , hemofiltration and hemodiafiltration , and use of such a degassing device in an extracorporeal circuit for degassing gas bubbles out of liquid , e . g ., blood , e . g ., during hemodialysis , hemofiltration and hemodiafiltration , are disclosed .