the following description refers to the accompanying drawings that illustrate certain embodiments of the invention . other embodiments are possible and modifications can be made to the embodiments without departing from the spirit and scope of the invention . therefore , the following detailed description is not meant to limit the present invention . rather , the scope of the present invention is defined by the claims . the present invention arises from the realization that the basic architecture of a frequency - domain oct ( fd - oct ) system , configured in a specific manner , permits a user to make an intravascular blood pressure measurement when used in conjunction with fiber - optic fabry - perot pressure transducers . fig1 illustrates the basic structure of a fabry - perot optical pressure transducer 10 , known to the prior art , that is compatible with the combined oct imaging / pressure measurement system disclosed herein . a fabry - perot cavity 14 is formed by the surfaces of a diaphragm 18 and the sensor body 22 and has a reflectivity that depends on optical frequency or wavelength of the light exiting the optical fiber 26 . the depth of the cavity lies typically within the range of 1 - 20 μm and its width , which is limited by the diameter of the body of the sensor , lies typically in the range of 0 . 15 - 0 . 4 mm . light from an optical fiber 26 impinges on the cavity 14 and the same fiber 26 collects the reflected light as the diaphragm 18 flexes in response to external pressure variations . when the sensor 10 is excited by a laser , the optical signals returning from the cavity 14 through the optical fiber 26 combine and generate a common - mode interference signal . an pd - oct system , configured according to the present invention , performs the functions required to record these interference signals . algorithms are discussed below for processing the interference signals and displaying blood pressure waveforms . one embodiment of an fd - oct system 30 that is suitable for combined oct imaging and blood pressure measurement according to the present invention is shown in fig2 . because it performs both functions with little additional hardware , it is a simple cost - effective embodiment of the combined system . a wavelength - swept laser 34 ( also referred to as an ‘ optical - frequency tunable laser ’ or ‘ swept - source laser ’) emits nearly monochromatic ( line width & lt ; 0 . 2 nm ) near - infrared light within a specific spectral band suitable for intravascular oct imaging . the most common band of emission wavelengths lies within the telecommunications o band ( 1260 ≦ λ ≦ 1360 nm ). the wavelength of the laser 34 is swept or stepped rapidly over a broad band of wavelengths . the sweep is completed typically within a period less than 20 μs and repeats 10 , 000 times or more each second . an optical power splitter 38 separates the light into three channels . the first channel , which includes a fiber bragg grating filter 42 ( or equivalent wavelength - selective filter ) with a narrow bandpass ( typically & lt ; 1 nm ) and a trigger generator 46 , provides a timing pulse to the main analog - to - digital converter 50 that triggers the data acquisition . this channel produces a tinting pulse at a predetermined optical frequency or wavelength ( typically 238 thz or 1260 nm ) when the output of the laser sweeps through the passband of the fiber bragg grating filter . the timing pulse triggers the start of the acquisition of the analog signals from the photoreceiver on each edge of the sample clock . light in the second channel is routed through a single - mode optical fiber to a sample clock generator 54 , which includes a reference interferometer and associated electro - optics that generate sample clock pulses at fixed optical frequency intervals . the sample clock generator ensures that the signals from photoreceiver 94 are collected by the data acquisition and display unit 102 synchronously with the sweep of the laser 34 at known wavelength steps . a fiber - optic mach - zehnder , michelson interferometer , optical etalon , or equivalent type of interferometer with a known optical path difference can serve as the reference interferometer of the clock generator 54 . light in the third channel is conducted through a single - mode optical fiber to the main interferometer 58 which splits the light into reference 60 and sample arms 62 . the light in the reference arm passes through an optical switch 64 to a reference mirror 66 that sets the zero - point optical delay for the imaging system and determines the depth into the tissue at which the oct imaging will take place . the light in the sample arm 62 passes to a motorized fiber - optic rotary coupler 70 in the probe interface 74 . the probe interface 74 includes a connector 78 which permits various probes ( combined oct imaging / pressure measuring catheter 82 , oct imagining 86 or optical pressure measuring probe 90 ) to connect to the sample arm 62 of the interferometer 58 . a motorized translation stage in the probe interface 74 enables the fiber - optic core of the catheter ( 82 , 28 , 90 ) inserted into a vessel to pull back with a constant speed . the optical output of the main interferometer 58 is converted by the photodetector 94 to electrical signals representative of the interference signals from the sample 60 and reference arms 62 of the interferometer 58 . these electrical signals are converted to digital signals by the analog to digital converter ( a / d ) 50 and processed and displayed on the display unit 98 of the data acquisition system 102 . because the trigger generator 46 and clock generator 54 are synchronized , the absolute optical frequency of the interference signal acquired by the data acquisition system 102 during every laser sweep can be determined from the number of sample clock pulses acquired after each trigger pulse from the trigger generator 46 . the absolute frequency reference is provided , by the fiber - bragg grating , which indicates the starting optical frequency ; subsequent steps occur at equal optical frequency intervals set by the sample clock generator . in one embodiment of the invention shown in fig2 operates either in the oct imaging mode , pressure mode , or combined oct / pressure mode depending on whether an oct imaging 86 catheter , pressure probe 90 , or combined oct / pressure catheter 82 is attached to the probe interface connector 78 . the mode of operation can be selected manually or automatically , depending on the system configuration . manual selection requires the user to choose the operating mode from a software menu . automatic selection can be accomplished in one of several ways . in one embodiment with the motorized fiber - optic rotary coupler 70 in a stationary position , data acquisition unit 102 initiates after either the oct imaging catheter 86 or pressure probe 90 has been inserted . a software algorithm identifies the type of probe according to the interference signal pattern detected by the main interferometer 58 and photodetector 94 and loads the appropriate control and display software . once the pressure measurement has been completed , the precise location and the severity of the stenosis can be determined and the oct imaging procedure can begin . in a second embodiment of the system to automatically determine what type of probe is connected to the system , following insertion of the catheter 86 or pressure probe 90 , the system attempts to rotate the motorized fiber - optic rotary coupler 70 . a torque sensor in the motor of the motorized coupler 70 measures resistance to rotation . torque exceeding a specific threshold indicates that a pressure probe 90 , with a non - rotating proximal connection , is attached . once insertion of a pressure probe 90 has been detected , the motor disengages and the appropriate control and display software loads . in a third embodiment , an encoded electrical or optical tag ( e . g ., bar code , wire - encoded electrical connector , rfid tag , flash memory chip ) on the proximal end of the oct imaging catheter 86 or pressure probe 90 ( or both 82 ) is read by the system to identify the appropriate mode of operation . the tag can be read automatically by the probe interface 74 when the probe is inserted or , alternatively , a handheld device can be employed to read the marker from the body or package of the probe . this method of probe identification has the advantage that additional factory calibration data encoded in the markers can be read at the same time . in addition to features that enable automatic software configuration , the system of fig2 also contains features that enable automatic hardware configuration once the operational mode has been determined . in the standard oct imaging mode , optical switch 64 is actuated , allowing light to reflect from the reference mirror 66 . however , in the pressure - measurement mode , because the system records common - mode interference signals and no reference light is required , the optical switch 64 is turned off , isolating the reference reflector 66 from the reference arm 60 of the interferometer 58 . in addition , since differential ( balanced ) photodetection is employed , only during oct imaging , the electronic balancing circuits in the photoreceiver 94 are switched to the single - ended ( unbalanced ) mode during pressure measurements . fig3 is a block diagram of another embodiment 30 ′ of the invention in which separate optical connections are provided on the probe interface 74 ′ for the oct imaging catheter 86 and optical pressure probe 90 . this configuration enables acquisition of blood pressure measurements with a separate pressure probe 90 before , during , or after oct imaging . measurement of pressure during oct imaging can be accomplished by inserting both probes in the blood vessel at the same time . an additional optical channel 112 from the power splitter 38 ′ directs light to the pressure probe 90 through an optical circulator 116 . the optical circulator 116 re - directs the light that returns from the pressure probe 90 into a second photodetector 120 that generates the electronic signal corresponding to interference signals from which the pressure measurements are derived . these signals are digitized by a second channel of the analog to digital converter 50 ′ and recorded by the same data acquisition system 102 ′ used to record the oct interference signals . in contrast to the first embodiment of the invention illustrated by fig2 , no optical switch 64 is required in the reference arm 60 to isolate the reference arm 60 from the reference reflector 66 ( fig2 ) during pressure measurement . a third embodiment of invention 30 ″, illustrated in fig4 , is similar to that shown in fig3 , except a multi - mode ( mm ) fiber 124 is used instead of a single - mode ( sm ) fiber 112 to conduct light over part of the path from the laser 34 to the optical pressure probe 90 . the larger core of the multi - mode ( mm ) fiber 124 facilitates fabrication of the pressure probe and reduces the tolerances for aligning the fiber - optic connection at the probe interface 78 ′ to the proximal end of the pressure probe . typically , a 50 - μm or 62 . 5 - μm diameter graded - index mm telecommunications fiber may be used in this application . to reduce inter - modal interference noise , a passive sm - to - mm converter 128 , may be employed to launch light from the laser 34 into the mm fiber 124 . fig5 illustrates a fourth embodiment 30 ″′ of the invention that enables simultaneous acquisition of oct images and pressure measurements from a single fiber - optic catheter that contains both an oct optical lens assembly and an optical pressure transducer as described below . the oct and pressure interference signals are detected in two non - overlapping wavelength bands , for example , 1250 - 1350 nm and 1500 - 1600 nm or 1000 - 1200 nm and 1500 - 1600 nm , respectively . a superluminescent diode 130 emits broadband light that combines with the oct laser light in a wavelength - division multiplexer 134 after passing through an optical circulator 138 . the combined light from the main interferometer 58 sample arm 62 and the superluminescent diode 130 travels in the same sm optical fiber to the tip of the catheter where light in the appropriate band ( as described below in conjunction with the probe ) impinges upon and reflects from either the tissue or the pressure transducer the reflected light is passed back down the fiber and separated again into two wavelength bands by the wavelength division multiplexer 134 . light reflected by the tissue in first band enters the main oct interferometer 58 through the sample arm 62 and light reflected by the pressure transducer in the second band enters a spectrometer 40 again after passing through the optical circulator 138 . the spectrometer 140 records the spectrum of the light reflected from the pressure transducer and transmits the spectral data to the processor and display system 98 ′ over a digital interface . fig6 - 10 illustrate the designs of pressure - sensing catheters that are compatible with an fd - oct system configured according to the various embodiments of the invention . each of the catheters contains a miniature optical pressure sensor at the tip of a small - diameter ( 80 μm - or 125 μm - diameter ) optical fiber . the diameters of the sensor and fibers are small enough to enable the fabrication of pressure - sensing catheters with dimensions of coronary and neurovascular guide wires ( 0 . 010 - 0 . 014 ″). fig6 ( a - b ) show cross - sectional views of the proximal and distal ends of one of the embodiments of the optical pressure probe . the pressure probe 90 includes of a long hollow flexible tube 150 or an assembly of tapered tubes with an optical transducer 10 ′ mounted at the base of a spring tip 154 located at the distal end of the probe . the optical fiber 155 from the pressure transducer 10 ′ connects to a fiber - optic connector 157 mounted on the proximal end of the probe . pressure - sensing slots or holes 160 in the mounting collar 164 at the base of the spring tip 154 transmit the blood pressure from the vessel in which the probe is inserted to the diaphragm 18 of the pressure transducer 10 ′. alternatively the optical pressure transducer 164 is exposed to the blood flow directly . preferably , the hollow body of the tube 150 is composed of a metal , metal alloy , or metal - braided polymer that gives the tube sufficient resistance to compression and rigidity to torque , while maintaining a high degree of flexibility . to minimize the restriction of flow caused by placement of the probe across a tight stenosis in a blood vessel , the body of the probe at its distal end is fabricated typically with an outer diameter of 0 . 010 - 0 . 018 ″ ( 0 . 25 - 0 . 46 mm ). to position the pressure probe , the operator inserts the probe through a guide catheter into the artery and steers the probe to the target location using a torque handle 168 located near the proximal end . in accordance with the design of the fd - oct system of fig2 , operating in the pressure measurement mode , the fiber - optic rotary coupler 70 in the probe interface 74 rotates passively . the tip of the pressure probe 90 can be steered to the target location in the blood vessel by disconnecting the fiber - optic connector from the probe interface to allow free rotation of the body of the probe . after the pressure wire has been positioned , the fiber - optic connector can then be re - inserted into probe interface to obtain pressure measurements . alternatively , since the fiber - optic rotary coupler in the probe interface rotates passively , the tip of the pressure probe can be steered without disconnecting the fiber - optic connection . fabricating the pressure probe with a longer body (˜ 2 meters ) facilitates this alternative steering method . if the probe interface does contain a rotatable element , the proximal end of the transducer may be made flexible between the removable torque handle 168 and the angle polished fiber optic connector 157 . this allows the pressure wire to be steered with a simpler probe interface unit . it should be noted that the diameter of the probe need not be constant across the transducer . fig6 c depicts a cross - sectional view of the probe of fig6 a but in which the diameter of the probe varies . the widths distal ( d ) and proximal ( d ′) to the transducer 164 are less that the width necessary to encompass the transducer 164 . this configuration functions because the wider diameter at the transducer 164 and opening 160 is not located within the stenotic region when pressure is measured . hence , the diameter of the vessel in the region outside the stenosis is sufficiently large to permit pressure to enter through hole 160 without constricting flow and generating an anomalous pressure reading . fig7 ( a - b ) show cross - sectional views of an alternative construction of an optical pressure probe . similar to the probe shown in fig6 , the distal end of the probe shown here is constructed from a long flexible hollow tube 150 or an assembly of tapered tubes with the pressure sensing port located at the base of its spring tip 154 . however , the probe shown in fig7 b includes a disposable optical adapter 172 that gives the operator access to the proximal end of the adapter . this configuration enables the pressure probe to serve as a primary guide wire over which a balloon catheter or other interventional device can be inserted into the artery . for compatibility with standard devices employed in coronary interventions , the pressure probe is fabricated , with an outer diameter of less than 0 . 014 ″ ( 0 . 36 mm ) over its entire length . an end - polished fiber - optic ferrule 176 , with an outer diameter approximately equal to that of the body of the probe , mates precisely with a similar fiber - optic sleeve 180 inside the optical adapter 172 . to maintain a high optical transmission during free rotation of the proximal end , while minimizing back reflection , the mating fiber - optic ferrules 176 , 180 are fabricated , preferably , with ultra physical contact ( upc ) polished end faces . in some embodiments , separate disposable optical adapter 172 , which is supplied to the user as a separate sterilized component , plugs into the probe interface of the fd - oct system and remains connected throughout the procedure . at the completion of the procedure , the adapter and the probe are removed as a unit by the user for disposal . to position the pressure probe 90 ′, the operator the proximal end of the probe 90 ′ from the optical adapter 172 , inserts the probe 90 ′ through a guide catheter into the artery , and steers the probe 90 ′ to the target location using the removable torque handle 168 at the distal end . once the wire has been positioned and any additional device has been inserted over the pressure probe , the operator re - inserts the proximal end of the probe into the optical adapter 172 and locks the clamp 184 to keep the surfaces of the optical fibers 176 , 180 in close contact if the pressure probe 90 ′ moves . fig8 ( a - b ) show yet another alternative construction of an optical pressure probe 90 ″ that is suitable for intravascular pressure measurement with an fd - oct system configured according to the various embodiments of the invention . unlike the pressure probes 90 , 90 ′ illustrated in fig6 and 7 , this version of the pressure probe is designed for rapid delivery over a primary guide wire . in many instances , especially when an artery is tortuous or otherwise difficult to access , the clinician prefers to employ an independent primary guide wire rather than to steer the unsupported pressure probe to the target site . the guide wire ( not shown ) is inserted at the probe tip 190 and exits through the guide wire exit 194 . the guide wire is inserted into the vessel and moved to the position of interest in the vessel . the pressure probe 90 ″ is next inserted into the vessel over the guide wire and also moved to the place of interest in the vessel . the position of the pressure transducer can be monitored under x - ray imaging using the radio - opaque marker 198 located on the probe . the guide wire may then be removed and the pressure measurements performed . eliminating the need for steerability of the pressure probe 90 ″ makes the rapid - exchange pressure wire easier and less costly to fabricate ; however , to minimize restriction of blood flow , its cross section should be kept small . therefore , to avoid inaccurate measurement of vascular resistance , the relatively large - diameter tip of the pressure probe must be placed far enough away from a tight vessel stenosis to prevent further restriction of blood flow . to satisfy this constraint , in one embodiment , the distance from the exit port of the guide wire to the pressure sensor ( labeled ‘ l ’ in fig8 a ) is set to 2 - 4 cm . the offset of the pressure sensor 10 ′ relative to the tip 190 enables the user to place the largest - diameter segment of the probe outside of the stenosis during the measurement of pressure both distal and proximal to the stenosis . the utility and ease of use of the rapid - exchange version of the pressure probe can be improved by modifying its construction according to fig9 ( a - b ). the distal end of the pressure probe 90 ″ shown in this figure includes a series of ports 160 ′ at evenly spaced intervals ( typically 2 - 5 mm ) that transmit the pressure at particular points along the axis of the artery to the inner lumen of the probe . an optical pressure transducer 10 ′ at the tip of an optical fiber inside the lumen of the pressure probe senses the local pressure in the vicinity of the pressure ports . the optical fiber and attached pressure transducer are designed to translate longitudinally inside the lumen as the motor inside the probe interface pulls the fiber connector back at a constant speed . before use , the probe is flushed with saline . a liquid seal at the proximal end between the optical fiber and the non - rotating shell over the body of the fiber - optic connector prevents the escape of fluid into the probe interface . to perform a pressure measurement , the clinician , inserts the tip of probe 90 ″′ across the target lesion and pushes it forward until the target lesion lies between the radio - opaque markers 198 ′, 198 ″ on both sides of the series of pressure ports . the measurement is initiated by activating the automated pullback mechanism ( part of the standard fd - oct probe interface ), which pulls the transducer 10 ′ along the length of the probe 90 ″ lumen at a constant velocity adjacent the series of pressure - sensing ports 160 ′. the pressure measured as a function of time provides a profile of the pressure across the lesion . fig9 d shows an embodiment of a multi - hole probe within the lumen of a stenotic vessel . fig9 e shows the measured pressure at various positions in the vessel corresponding to the cross - section in fig9 d and the pressure values measured by the transducer at each of the holes in the probe . fig9 f shows the pressure readings by the transducer as it is moved by the individual holes . because the transducer determines the pressure downstream ( distal ) from it , a stepped pressure measurement is obtained as the transducer moves by the individual holes . the pressure errors introduced by this technique are minimal . fig1 is a cross - sectional view of the tip of a catheter that combines the functions of an intravascular oct imaging probe and a pressure wire . depending on its construction , the combination catheter is compatible with the embodiments of the fd - oct system shown in fig2 and fig5 . the key feature of the combined catheter is the integration of the pressure transducer into the tip of the oct imaging catheter . an optical fabry - perot pressure transducer 10 ″ is mounted on the distal end of a short length ( typically 1 - 2 mm ) of coreless or large - core step - index multimode fiber 26 ′. the distal end 202 of the fiber segment is polished at an angle of 40 - 50 degrees and coated with a thin dielectric or metallic film . to avoid excessive back - reflection from the distal end of a fiber - tip lens assembly 206 , the fiber segment 26 ′ with the attached transducer is glued to the fiber - tip lens assembly 206 with an adhesive 210 that matches the refractive index of the lens 206 . for use of the combination catheter with the fig2 embodiment of the fd - oct system in which both the oct system and pressure transducer operate in the same wavelength band ( typically 1260 - 1360 nm ), the thin - film coating on the angle - polished end of the fiber segment is selected to reflect a large fraction ( 75 - 90 %) of the incident light at specific wavelengths for oct measurements and to transmit the remaining fraction to the transducer 10 ″ for pressure measurements . since reflection from the fabry - perot cavity of the pressure transducer 10 ″ modulates the spectrum of the raw oct interference signal a series of artifactual lines appear in the oct image at a depth proportional to the modulation frequency . to avoid degradation of the oct image caused by these lines , the zero point of the oct interferometer can be set by setting the delay in the interferometer such that the lowest frequency of the displayed oct signals exceeds the peak frequency of the spectral modulation . for use of the combination catheter with the fig5 embodiment of the fd - oct system in which the oct system and the pressure transducer operate in the first and second wavelength bands , respectively ; the thin - film coating on the angle - polished end 202 of the fiber segment 26 ′ is selected to reflect light maximally in the first wavelength band and to transmit light maximally in the second wavelength band . with the lens 206 and pressure transducer 10 ″ attached to its tip , the optical fiber mounts inside the lumen of torque wire 214 that rotates inside the catheter sheath 218 . the catheter sheath is filled from the proximal port with saline or contrast medium . during pressure monitoring , the rotation of the torque wire 214 is turned off . the distal end of the catheter can employ either a monorail tip for rapid - exchange delivery , as in the embodiments shown in fig8 and fig9 , or a spring tip for insertion in the artery without a guide wire , as shown in the pressure wire embodiments in fig6 and fig7 . other beam - splitting arrangements at the catheter tip are also possible . for example , the fiber - tip lens assembly can be angle - polished and coated , rather than the fiber attached to the transducer . also , a bulk optical component ; such as miniature prism or mirror , can be employed as a beam splitter instead of an angle - polished optical fiber . fig1 shows a set of common - mode interference signals acquired from an optical pressure probe connected to an fd - oct system that was configured according to the embodiment of the invention shown in fig2 , operating in the pressure measurement mode . acquired over a range of pressures (− 40 mmhg & lt ; p & lt ; 180 mmhg ), the signals were recorded at successive optical dock intervals , in proportion to the wavenumber or optical frequency of the wavelength - swept laser . in this example , the abscissa spans an optical frequency range of 220 - 240 thz or , equivalently , a wavelength range of 1250 - 1360 nm . the low - frequency spectral modulation of the signal originates from reflections within the main fabry - perot cavity formed by the diaphragm and the body of the in the optical pressure transducer . the width of the cavity of the transducer in this example was approximately 17 μm . as shown by the arrows in fig1 , the low - frequency modulation pattern shifts to higher frequencies in proportion to pressure . the high - frequency spectral modulation superimposed on the signal was caused by reflection from a “ parasitic cavity ” in the transducer 10 ′ formed by the interface between the input optical fiber 26 ′ and the sensor body 22 . neither the frequency nor the amplitude of this parasitic modulation changes significantly with pressure . the characteristics of the time - dependent interference signal generated by the pressure transducer at the output of the photodetector ( see for example 120 in fig4 ) of the fd - oct system can be expressed as : v ( t )= kp 0 ( k )└ r fp ( k , p )+ r p ( k )┘ ( 1 ) where k is a constant , p 0 ( k ) is the optical power incident on the transducer ; r fp ( k , p ) and r p ( k ) are , respectively , the reflectivities of the fabry - perot and parasitic cavities of the pressure transducer . the interference signal , power , and transducer reflectivities are functions of the optical wavenumber ( k ) of the light emitted by the laser , which varies as an arbitrary function of time ( t ). in the fd - oct system , the signal voltage ( v ) from the photodetector 94 is sampled by the analog - to - digital converter 50 at evenly spaced wavenumber intervals , k n = k 0 +( n − 1 ) δk ; here , k 0 is the initial wavenumber of the laser sweep , δk is the wavenumber sample interval , and n = 1 , 2 , . . . n , where n is the number of samples . according to these definitions , the recorded digital pressure signal can be expressed as an array of n values measured at successive optical clock intervals ( in proportion to wavenumber ), v n = kp 0 ( k n )[ r fp ( k n , p )+ r b ( k n )], for n = 0 , 1 , 2 , . . . n ( 2 ) the reflectivity r fp varies in relation to the pressure - dependent length , l ( p ), of the fabry - perot cavity , according to : here , the magnitude of the effective reflection coefficient of the cavity , | r c |, is approximately equal to the geometrical mean of the magnitudes of the reflection coefficients of the reflecting surfaces of the fabry - perot cavity . for most transducers , the length ( l ) decreases approximately linearly with pressure over a wide range of pressures . the parasitic reflectivity , r b ( k ), generated by m parasitic cavities within the transducer &# 39 ; s body or packaging , generates pattern noise composed of sinusoids of different frequencies , r p ( k n )=| r p1 | sin ( 2 k n l 1 )+| r p2 | sin ( 2 k n l 2 )+ . . . +| r pm | sin ( 2 k n l m ) ( 4 ) where | r p1 |, | r p2 |, . . . , | r pm | are the magnitudes of the effective reflection coefficients of the parasitic cavities and l 1 , l 2 , . . . l m are the lengths of the parasitic cavities . these three equations , 2 , 3 and 4 represent a mathematical model of the signal recorded by the fd - oct system . the nominal fabry - perot cavity length ( l ) at a given pressure in equation 3 is known from the manufacturing process . the reflection coefficient | r c | is determined by fitting signals measured from a sampled number of pressure transducers . in practice , a single parasitic cavity usually dominates , and its length and effective reflection coefficient can be determined by fourier transformation of pressure signals measured from the sampled number of pressure transducers . in accordance with the present invention , the algorithm for processing the pressure signal proceeds according to following steps : first the signal is normalized by dividing the recorded signal array of voltages ( v n ) by the laser power to obtain the normalized signal : next the parasitic cavity noise is removed by applying a butterworth or equivalent low - pass filter to the normalized signal ( v n 0 ) with a cut - off frequency below that of the lowest frequency component of the reflection coefficients r p ( k ). the result is : where lpf { } represents the low - pass filtering operation . next the spectral null , the sample wavenumber at which the amplitude of v n , f 0 is lowest , is detected . v n , f 0 is first convolved with a template array of values proportional to r fp ( k ), with | r c | and l ( p ) determined by fitting filtered arrays measured from a sample of transducers at reference pressures . the spectral null of v n , f 0 occurs at the array index n min at which the amplitude of the convolved is maximum . alternatively , the minimum , maximum or steepest edge of v n , f 0 can be located by conventional differentiation or gradient - search methods known to persons skilled in the art . the spectral null is then tracked and unwrapped . if more than one spectral null of v n , f 0 occurs within the pressure range of interest or nulls move out of the laser &# 39 ; s wavelength band at the extremes of the pressure range , the position of nulls can be tracked across multiple laser sweeps to extend the pressure measurement range . tracking can be accomplished by standard phase unwrapping techniques applied to a sequence of stored v n , f 0 array values . fig1 shows a calibration , curve of a typical pressure transducer . the curve was obtained by applying the above algorithm to the raw pressure signals in fig1 . since the optical clock interval number at which the spectral null occurs , n min , varies approximately in linear proportion to the applied pressure , the pressure can be estimated accurately from n min once the slope and offset of the calibration curve are known . in practice , a polynomial function is used to fit the calibration curve of an individual pressure probe or catheter and the stored coefficients are employed to estimate pressure from measured n min values . fig1 shows dynamic pressure waveforms measured by the same pressure probe from which the raw signals in fig1 were obtained . in this example , good correspondence compared to a commercial strain - gage transducer was obtained by using a simple first - order polynomial ( linear ) calibration curve . fig1 shows the pressure waveforms measured by the pressure probe across a tight stenosis in a simulated artery . in this experiment , the pressure - sensing segment of the pressure probe was pulled through the stenosis at a constant speed by a motor in the probe interface . the sharp reductions in both mean and pulsatile pressures provide clear evidence of the flow resistance imposed by the stenosis . the examples presented herein are intended , to illustrate potential and specific implementations of the invention . it can be appreciated that the examples are intended primarily for purposes of illustration of the invention for those skilled in the art . there may be variations to these diagrams or the operations described herein without departing from the spirit of the invention . for instance , in certain cases , method steps or operations may be performed or executed in differing order , or operations may be added , deleted or modified . variations , modification , and other implementations of what is described herein will occur to those of ordinary skill in the art without departing from the spirit and scope of the invention as claimed . accordingly , the invention is to be defined not by the preceding illustrative description , but instead by the spirit and scope of the following claims .
an optical coherence tomography system and method with integrated pressure measurement . in one embodiment the system includes an interferometer including : a wavelength swept laser ; a source arm in communication with the wavelength swept laser ; a reference arm in communication with a reference reflector ; a first photodetector having a signal output ; a detector arm in communication with the first photodetector , a probe interface ; a sample arm in communication with a first optical connector of the probe interface ; an acquisition and display system comprising : an a / d converter having a signal input in communication with the first photodetector signal output and a signal output ; a processor system in communication with the a / d converter signal output ; and a display in communication with the processor system ; and a probe comprising a pressure sensor and configured for connection to the first optical connector of the probe interface , wherein the pressure transducer comprises an optical pressure transducer .