the present invention relates to novel complexes of aluminum chlorhydroxide or aluminum chlorhydroxide propylene glycol and glycine and , more particularly , to an aluminum chlorhydroxy glycinate complex and an aluminum chlorhydroxy propylene glycol glycinate complex . the novel complexes of this invention may be depicted as having the formulas : [ al 2 ( oh ) 4 cl ] x . [ h 2 nch 2 cooh ] y ( aluminum chlorhydroxy glycinate ) and [[ al 2 ( oh ) 4 cl ] [ c 3 h 8 o 2 ]] x . [ h 2 nch 2 cooh ] y ( aluminum chlorhydroxy propylene glycol glycinate ) wherein x and y are each about 1 and refer to the number of mols of each component . in the foregoing formulas , al 2 ( oh ) 4 cl represents aluminum chlorhydroxide , h 2 nch 2 cooh represents glycine and c 3 h 8 o 2 represents propylene glycol . it is not necessary to utilize special reaction conditions to form the desired complexes . the complexes may be formed by a procedure in which the aluminum chlorhydroxide or aluminum chlorhydroxy propylene glycol are combined with glycine and formed into a uniformly mixed damp mass with the addition of small quantities of water . the dmp mass is then dried at 160 ° to 180 ° f . until the product is dry and has a relatively constant weight . in another procedure , boiling water is added to a mixture of aluminum chlorhydroxide or aluminum chlorhydroxy propylene glycol and glycine . the amount of water used in the reaction is not critical so long as an amount is utilized sufficient to wet the intimate mixture of reactants and form a slurry or solution of the reactants . after the reaction is complete , water is preferably removed from the product to a level below about 1 %, by weight , based on the weight of the complex . this may be accomplished by heating the complex to a temperature of from about 150 ° f . to about 160 ° f . until the product is dry and has a relatively constant weight . any drying means , including spray drying , may be employed , and vacuum may be employed to assist drying . it has also been found that the desired complexes may be prepared in a solid state reaction in which aluminum chlorhydroxide or aluminum chlorhydroxy propylene glycol are combined with glycine and thoroughly blended to form a uniform mixture . the mixture is then passed through a micronizer where the material is pulverized to an extremely fine size ( generally less than 10 microns ) and intimately admixed with the formation of the desired complex occurring in a solid state reaction . the relative proportions of aluminum chlorhydroxide or aluminum chlorhydroxy propylene glycol and glycine utilized in forming the desired complexes may vary somewhat . regardless of the proportions , however , the products are complex chemical compounds in which the components are chemically bound . in the complexes of this invention , the aluminum chlorhydroxide or aluminum chlorhydroxy propylene glycol are preferably combined with glycine in a mol ratio of about 1 to 1 . therefore , in the preferred embodiments of this invention aluminum chlorhydroxide and glycine are combined in a mol ratio of about 1 to 1 to form the aluminum chlorhydroxy glycinate complex . likewise , aluminum chlorhydroxy propylene glycol and glycine are combined in a mol ratio of about 1 to 1 to form the aluminum chlorhydroxy propylene glycol glycinate complex . it has been found that the complexes produced as the result of the present invention are remarkably stable whether in solution ( aqueous or alcohol ) or heated . the complexes have the combined attributes of the aluminum containing compound and glycine , e . g . the astringent , bacteriostatic properties of the aluminum chlorhydroxide component and the buffering , moisturizing and conditioning properties of glycine . the complexes are thus useful in a myriad of topical preparations such as deodorants , antiperspirants and the like . the complexes have been found to be especially useful in antiperspirant - deodorant products especially antiperspirant - deodorant products formulated with aluminum salts such as aluminum sulfate , aluminum chloride and aluminum chlorhydroxide . such products cause staining , destruction or charring of wearing apparel which becomes impregnated with the aluminum salts through contact with those areas of the body where the antiperspirant - deodorant products have been applied . high temperatures encountered in laundering , ironing or pressing the apparel causes the impregnated aluminum salts to decompose forming their corresponding aluminum acids which cause the undesired staining and possible charring and destruction of the clothing . surprisingly , it has been found that formulating antiperspirant - deodorant products with the complexes of this invention eliminates the undesired staining and destruction of clothing . it is thought that the heat encountered in laundering causes ammonia to be released from the glycine component of the complex . the ammonia neutralizes the acid produced through decomposition of the aluminum salt portion of the complex , thereby eliminating the destructive effects of the acid . it has further been found that the glycine phase of the complex acts as a buffer for any free acid liberated through body heat or perspiration . the complex thus contributes &# 34 ; built - in &# 34 ; anti - staining and buffering action to antiperspirant - deodorant products . the built - in buffering action imparts anti - irritant and hypoallergenic properties to antiperspirant - deodorant products , especially those products containing the aluminum chlorhydroxy glycine complex , thereby increasing the spectrum of persons who can utilize such products without adverse effects . the following examples illustrate the preparation of typical complexes and the properties and suggested uses for the complexes . the examples are illustrative only and not intended to limit the scope of the invention . 190 g . of aluminum chlorhydroxide are thoroughly mixed with 75 g . of glycine . 10 cc . of distilled water is then added and the mixture is triturated until a uniformed mixed damp mass is formed . the resulting mass is then dried for 1 / 2 to 1 hour at 160 ° to 180 ° f . to a dry - granular powder . the product is an aluminum chlorhydroxy glycinate complex having the formula : where x and y are each about 1 based on glycine and al 2 o 3 content . a 20 % aqueous solution of the complex has a ph of about 4 . 5 to about 6 . the complex is soluble to the extent of 40 to 50 % in water at 25 ° c . and 75 % in boiling water . the complex may be formulated in pharmaceutically acceptable carriers at levels of from about 10 to about 25 %, by weight , based on the weight of the product to form an antiperspirant composition . a like complex is formed by suspending 190 g . of aluminum chlorhydroxide and 75 g . of glycine in 200 cc . of boiling , distilled water , followed by evaporating the reaction mixture to dryness under reduced pressure at 150 ° to 160 ° f . similarly , a like complex is formed by thoroughly blending 190 g . of aluminum chlorhydroxide with 75 g . of glycine and micronizing the mixture to a particle size less than 10 microns . an aerosol antiperspirant - deodorant of the following formulation may be prepared with the aluminum chlorhydroxy glycinate complex : % w . w . ______________________________________aluminum chlorhydroxy glycinate complex 9noval 3crodafos n - 10 acid 0 . 5crodafos n - 10 neutral 0 . 5alcohol 41 . 75perfume 0 . 25propellant 45______________________________________ dissolve the aluminum chlorhydroxy glycinate complex in a portion of the alcohol with vigorous agitation and heat to 50 ° c . combine the additional ingredients with stirring and filter producing a concentrate which may be filled in corrosion resistant cans with the propellant in manners known in the art . 230 g . of aluminum chlorhydroxy propylene glycol are thoroughly mixed with 75 g . of glycine , 10 cc . of distilled water is then added and the mixture is triturated until a uniformly mixed damp mass is formed . the resulting mass is then dried for 1 / 2 to 1 hour at 160 ° f . to 180 ° f . to a granular powder . the product is an aluminum chlorhydroxy propylene glycol glycinate complex having the formula : [[ al . sub . 2 ( oh ). sub . 4 cl [ [ c . sub . 3 h . sub . 8 o . sub . 2 ]]. sub . x . [ h . sub . 2 nch . sub . 2 cooh ]. sub . y where x and y are each about 1 based on glycine and al 2 o 3 content . a 20 % solution of the complex has a ph of about 4 . 5 to about 6 . 5 . the complex is soluble in alcohol and water . the complex may be formulated in pharmaceutically acceptable carriers at levels of from about 10 to about 25 %, by weight , based on the weight of the product to form an antiperspirant composition . a like complex is formed by suspending 230 g . of aluminum chlorhydroxy propylene glycol and 75 g . of glycine in 200 cc . of boiling , distilled water , followed by evaporating the reaction mixture to dryness under reduced pressure at 150 ° to 160 ° f . similarly , a like complex is formed by thoroughly blending 230 g . of aluminum chlorhydroxy propylene glycol and 75 g . of glycine and micronizing the mixture to a particle size less than 10 microns .
an aluminum chlorhydroxy glycinate complex is disclosed as is an aluminum chlorhydroxy propylene glycol glycinate complex . medicinal and cosmetic compositions containing these complexes are also disclosed .