in order to make those skilled in the art better understand technical solutions of the present application , the technical solutions of the examples of the present application will be clearly and fully described below by making reference to the accompanying drawings of the examples of the present application . obviously , the described examples are merely a part of the examples of the present application , but not all examples . based on the examples of the present application , all other examples obtained by those of ordinary skill in the art without creative efforts , should fall within the protection scope of the present application . the examples of the present application provide an interventional medical device , comprising a stent body with a drug releasing structure , wherein the drugs in the drug releasing structure are drugs for suppressing proliferation of adventitial fibroblasts and for suppressing proliferation of intimal cells and / or smooth muscle cells . fig1 is a structural schematic diagram of a specific embodiment of the interventional medical device provided by the present application . as shown in fig1 , 1 indicates stent body , 2 indicates drug releasing coating . drug releasing coating 2 is coated on the outer surface of stent body 1 , in which : stent body 1 can be a coronary artery stent , intracranial vascular stent , peripheral vascular stent , intraoperative stent , heart valve stent , biliary tract stent , esophageal stent , intestinal tract stent , pancreatic duct stent , urethral stent or tracheal stent . furthermore , the material of stent body 1 can be a material with good biocompatibility and mechanical characteristics , such as stainless steel , cobalt - based alloy , nickel - based alloy , titanium alloy , degradable magnesium alloy or a polymer material , etc . drug releasing coating 2 is a dense mixed layer formed by the polymer and the drug for suppressing adventitial fibroblast proliferation and the drug for suppressing proliferation of intimal cells and / or smooth muscle cells . that is , drug releasing coating 2 is used as a carrier to allow the surface of stent body 1 to carry drugs . drug for inhibiting adventitial fibroblast proliferation includes at least one drug selected from the group consisting of tanshinone , asiaticoside , madecassoside , ligustrazine , dracorhodin , rosuvastatin , angiotensin . in the examples of the present application , asiaticoside is preferred . drug for suppressing proliferation of intimal cells and / or smooth muscle cells can be at least one drug selected from the group consisting of rapamycin and derivative thereof and paclitaxel and derivative thereof , with rapamycin is preferred . in addition , the polymer in drug releasing coating 2 can be a polymer having biocompatibility and controlled release properties , such as , polylactic acid , polyethylene glycol , styrene - butene copolymer , polycaprolactone , poly ( butyl methacrylate ), poly ( ethyl methacrylate ), polyvinyl ethyl acetate , polyurethane , polyvinyl pyrrolidone , polyphosphorylcholine , silk protein , gelatin , chitin and / or hyaluronic acid . asiaticoside is the total glycosides extracted from umbelliferae centella asiatica . asiaticoside can inhibit the pathological role of tgf - beta by increasing expression of smad7 that inhibits smad transduction signal , thereby functioning in vascular remodeling by blocking fibroblast proliferation , promoting vascular compensatory expansion , thus reducing the occurrence rate of in - stent restenosis . furthermore , studies have found that asiaticoside could also promote endothelial cell growth and accelerate endothelialization process . for detailed , see “ experimental study of the effect of asiaticoside on preventing restenosis after percutaneous coronary intervention ( clc r541 . 4 article id : 1671 - 8259 ( 2005 ) 05 - 0477 - 03 ). thus it can be seen that , compared with the current drug - eluting stents using rapamycin , paclitaxel and derivatives thereof , the interventional medical device provided by the examples of the present application also promotes endothelial cell growth and accelerates the process of endothelialization . fig2 is a structural schematic diagram of another specific embodiment of the interventional medical device provided by the present application . as shown in fig2 , 1 indicates stent body , 3 indicates micropores formed on the surface of the stent . in the example of the present application , the drug releasing structure is micropore 3 . micropore 3 may be obtained by oxidating or eroding the surface of stent body 1 . drugs may be loaded within micropore 3 , thus , the surface of stent body 1 will carry drugs . fig3 is structural schematic diagram of another specific embodiment of the interventional medical device provided by the present application . in the interventional medical device shown in fig2 , micropore 3 is obtained by directly oxidating or eroding the surface of stent body 1 . however , in the example of the present application , a layer of microporous coating can be prepared on the surface of stent body 1 . as shown in fig3 , 1 indicates stent body , 4 indicates microporous coating . this eliminates the need for oxidating or eroding the surface of stent body 1 . on the contrary , microporous coating 4 is directly prepared on the surface of stent body 1 to obtain micropores loaded with drugs . fig4 is a technological process of the preparation method of the interventional medical device provided by the present application . as shown in fig4 , in the example of the present application , taking metal stent as an example of the stent body , the preparation method of the interventional medical device comprises : during the preparation of the interventional medical device , in order to prevent residual stains on the stent body from affecting the quality of the interventional medical device , it is necessary to clean the stent body first . step s 102 : preparing micropores on the surface of the stent body . micropores on the surface of the stent body are formed by electrochemical corrosion and / or chemical corrosion . electrochemical corrosion includes anodic oxidation , micro - arc oxidation and so on . micropores can be formed on the surface of the stent body by this step . fig2 shows their structural schematic diagram . step s 103 : formulating a solution containing a drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal cells and / or smooth muscle cells . in the example of the present application , preferably , the drug for suppressing proliferation of adventitial fibroblasts is asiaticoside , and the drug for suppressing proliferation of intimal cells and / or smooth muscle cells is rapamycin . a mixed solution of asiaticoside and rapamycin is formulated , in which asiaticoside : rapamycin = 2 : 1 ˜ 5 : 1 . when formulating , 10 mg rapamycin and 30 mg asiaticoside are dissolved in 10 ml ethanol solution . after they are dissolved , the mixture is mixed thoroughly . step s 104 : loading the drugs within the formulated solution into the micropores of the stent body . the stent body with micropores on its surface obtained in step s 102 is immersed into the solution formulated in step s 103 , so that the drugs within the solution can be loaded into the micropores on the surface of the stent body . step s 105 : drying the stent body to get the interventional medical device . fig5 is another technological process of the preparation method of the interventional medical device provided by the present application . as shown in fig5 , in the example of the present application , the preparation method of the interventional medical device comprises : step s 202 : preparing a coating having micropores on the surface of the stent body . particular process includes the following steps : the silk protein solution is uniformly coated on the surface of the stent body . then the stent body is subject to thermal or chemical denaturation , and infiltration by pure water . after that , the stent body is freezed and then the temperature is increased to dry the stent body . a coating with microporous structure is thus formed on the surface of the stent body . step s 203 : formulating a solution containing a drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal cells and / or smooth muscle cells . in the example of the present application , preferably , the drug for suppressing proliferation of adventitial fibroblasts is asiaticoside , and the drug for suppressing proliferation of intimal cells and / or smooth muscle cells is rapamycin . when formulating , 10 mg rapamycin and 50 mg asiaticoside are dissolved in 10 ml ethanol solution . after they are dissolved , the mixture is mixed thoroughly . step s 204 : loading the drugs within the formulated solution into the micropores of the coating on the surface of the stent body . the stent body with a microporous coating on its surface obtained in step s 202 is immersed into the formulated solution , so that the drugs within the solution can be loaded into the micropores of the coating on the surface of the stent body . step s 205 : drying the stent body to get the interventional medical device . fig6 is another technological process of the preparation method of the interventional medical device provided by the present application . as shown in fig6 , in the example of the present application , the preparation method of the interventional medical device comprises : step s 302 : formulating a mixed solution containing a drug for suppressing adventitial fibroblast proliferation , a drug for suppressing intimal cells and / or smooth muscle cell proliferation and a polymer . in the example of the present application , the polymer is polylactic acid , the drug for suppressing proliferation of adventitial fibroblasts is preferably asiaticoside , and the drug for suppressing proliferation of intimal cells and / or smooth muscle cells is preferably rapamycin . a mixed solution of polylactic acid , asiaticoside and rapamycin is formulated , in which the ratio of asiaticoside and rapamycin is in the range of 2 : 1 ˜ 5 : 1 , and the ratio of polylactic acid and asiaticoside is in the range of 1 : 1 ˜ 5 : 1 . when formulating , 10 mg rapamycin , 30 mg asiaticoside and 10 mg polylactic acid can be added to 10 ml tetrahydrofuran . after they are sufficiently dissolved , the mixture is mixed uniformly . step s 303 : coating the surface of the stent body with the mixed solution . in the example of the present application , the mixed solution formulated in step 302 can be coated on the stent body by ultrasonic spraying , air spraying or dipping . step s 304 : drying the stent body to get the interventional medical device . in fig6 , a mixed solution of two drugs and the polymer is formulated . however , in the practical application , two drugs can be mixed with the polymer respectively . then the mixed solutions of each drug are successively coated on the surface of the stent body . fig7 is another technological process of the preparation method of the interventional medical device provided by the present application . as shown in fig7 , in the example of the present application , the preparation method of the interventional medical device comprises : step s 402 : formulating a mixed solution containing a drug for suppressing adventitial fibroblast proliferation and a polymer , as well as a mixed solution containing a drug for suppressing intimal cells and / or smooth muscle cell proliferation and a polymer . in the example of the present application , preferably , the polymer is polylactic acid , the drug for suppressing proliferation of adventitial fibroblasts is asiaticoside , and the drug for suppressing proliferation of intimal cells and / or smooth muscle cells is rapamycin . solution of polylactic acid and asiaticoside and solution of polylactic acid and rapamycin are formulated respectively , in which , the ratio of polylactic acid and asiaticoside is in the range of 1 : 1 ˜ 4 : 1 , and the ratio of polylactic acid and rapamycin is in the range of 1 : 1 ˜ 4 : 1 . when formulating , 30 mg asiaticoside and 60 mg polylactic acid are added to 10 ml tetrahydrofuran . after they are sufficiently dissolved , the mixture is mixed uniformly to get a first drug solution . additionally , 10 mg rapamycin and 20 mg polylactic acid are added to 10 ml tetrahydrofuran . after they are sufficiently dissolved , the mixture is mixed uniformly to get a second drug solution . step s 403 : coating the surface of the stent body with the resultant two mixed solutions on , respectively and successively . when coating , asiaticoside / polylactic acid solution can be coated on the surface of the stent body first . then the sprayed stent body is placed in the air for 4 h to make its surface dried . after that , rapamycin / polylactic acid solution is coated on the surface of the dried stent body . during above - mentioned spray coating , asiaticoside / polylactic acid solution is sprayed first , followed by rapamycin / polylactic acid solution . this is only an example of the present application , and should not be construed to limit the present application . those of ordinary skill in the art should know that , in other examples , the spraying order of the two drug solutions can be freely chosen . in addition , in the example of the present application , ultrasonic spraying , air spraying or dipping and other means may be used . step s 404 : drying the stent body to get the interventional medical device . the above examples are only preferred embodiments of the present application . with these examples the skilled person can understand or realize the present application . various modifications to these examples will be apparent to the skilled person in the art , and the generic principles defined herein may be implemented in other examples without departing from the spirit or scope of the present application . accordingly , the present application will not be limited to these examples described herein , but meet the widest scope consistent with the principles and novel features disclosed herein .
an interventional medical device and manufacturing method thereof . the interventional medical device comprises : a stent body ; a surface of the stent body being provided with a drug releasing structure , and drug in the drug releasing structure being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and / or smooth muscle cells . in use , after interventional medical device is implanted into a human body , the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel , and the drug for suppressing proliferation of intimal cells and / or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel . the combination of the two kinds of drugs greatly reduces the occurrence rate of in - stent restenosis .