the preferred active compounds of the present invention are in an ionized , salt form or as the free base of the pharmaceutically acceptable salts thereof ( provided , for the aerosol or pump spray compositions , they are soluble in the spray solvent ). these compounds are soluble in the non - polar solvents of the invention at useful concentrations or can be prepared as pastes at useful concentrations . these concentrations may be less than the standard accepted dose for these compounds since there is enhanced absorption of the compounds through the oral mucosa . this aspect of the invention is especially important when there is a large ( 40 - 99 . 99 %) first pass effect . as propellants for the non polar sprays , propane , n - butane , iso - butane , n - pentane , iso - pentane , and neo - pentane , and mixtures thereof may be used . n - butane and iso - butane , as single gases , are the preferred propellants . it is permissible for the propellant to have a water content of no more than 0 . 2 %, typically 0 . 1 - 0 . 2 %. all percentages herein are by weight unless otherwise indicated . it is also preferable that the propellant be synthetically produced to minimize the presence of contaminants which are harmful to the active compounds . these contaminants include oxidizing agents , reducing agents , lewis acids or bases , and water . the concentration of each of these should be less than 0 . 1 %, except that water may be as high as 0 . 2 %. suitable non - polar solvents for the capsules and the non - polar sprays include ( c 2 - c 24 ) fatty acid ( c 2 - c 6 ) esters , c 7 - c 18 hydrocarbon , c 2 - c 6 alkanoyl esters , and the triglycerides of the corresponding acids . when the capsule fill is a paste , other liquid components may be used instead of the above low molecular weight solvents . these include soya oil , corn oil , other vegetable oils . as solvents for the polar capsules or sprays there may be used low molecular weight polyethyleneglycols ( peg ) of 400 - 1000 mw ( preferably 400 - 600 ), low molecular weight ( c 2 - c 8 ) mono and polyols and alcohols of c 7 - c 18 linear or branch chain hydrocarbons , glycerin may also be present and water may also be used in the sprays , but only in limited amount in the capsules . it is expected that some glycerin and water used to make the gelatin shell will migrate from the shell to the fill during the curing of the shell . likewise , there may be some migration of components from the fill to the shell during curing and even throughout the shelf - life of the capsule . therefore , the values given herein are for the compositions as prepared , it being within the scope of the invention that minor variations will occur . the preferred flavoring agents are synthetic or natural oil of peppermint , oil of spearmint , citrus oil , fruit flavors , sweeteners ( sugars , aspartame , saccharin , etc . ), and combinations thereof . the active substances include the active compounds selected from the group consisting of cyclosporine , sermorelin , octreotide acetate , calcitonin - salmon , insulin lispro , sumatriptan succinate , clozepine , cyclobenzaprine , dexfenfluramine hydrochloride , glyburide , zidovudine , erythromycin , ciprofloxacin , ondansetron hydrochloride , dimenhydrinate , cimetidine hydrochloride , famotidine , phenytoin sodium , phenytoin , carboprost thromethamine , carboprost , diphenhydramine hydrochloride , isoproterenol hydrochloride , terbutaline sulfate , terbutaline , theophylline , albuterol sulfate and neutraceuticals , that is to say nutrients with pharmacological action such as but not limited to carnitine , valerian , echinacea , and the like . in another embodiment , the active compound is an anti - arrhythmic , anti - hypertensive , heart regulator , cardiovascular agent , plaque stabilization agent , vasodilator , anti - anginal , anti - coagulant , anti - hypotensive , anti - thrombotic , drug for treating congestive heart failure , p - fox ( fatty acid oxidation ) inhibitor , or a mixture thereof . in one embodiment the active compound is an anti - arrhythmic . suitable anti - arrhythmics for use in the buccal sprays of the invention include , but are not limited to , adenosine , amiodarone , bepridil , bretylium , digitoxin , digoxin , diltiazem , disopyramide , dofetilide , d - sotolol , flecainide , lidocaine , mexiletine , milrinone , phenytoin , pilsicainide , procainamide , propafenone , propranolol , quinidine , tocainide , dofetilide , and mixtures thereof . in one embodiment the active compound is an anti - hypertensive . suitable anti - hypertensives for use in the buccal sprays of the invention include , but are not limited to , acebutolol , alfuzosin , amlodipine , atenolol , amlodipine / benazepril , barnidipine benazepril , bepridil , betaxolol , bisoprolol , bosentan , candesartan , captopril , cariporide , carvedilol , celiprolol , cilazapril , clonidine , diltiazem , doxazosin , enalapril , eplerenone , eprosartan , esmolol , felodipine , fenoldopam , fosinopril , guanfacine , imidapril , irbesartan , isradipine , labetalol , lercanidipine , lisinopril , losartan , manidipine , methyldopa , metoprolol , moxonidine , nadolol , nicardipine , nicorandal , nifedipine , nitrendipine , nosoldipine , omapatrilat , perindopril erbumine , pindolol , prazosin , propranolol , quinapril , ramipri , sotalol , spirapril , tamsulosin , telmisartan , terazosin , torsemide , trandolapril , valsartan , vatanidipine , midodrine , and mixtures thereof . in one embodiment the active compound is a heart regulator . suitable heart regulators for use in the buccal sprays of the invention include , but are not limited to , digoxin , digitoxin , dobutamine , and mixtures thereof . in one embodiment the active compound is a cardiovascular agent . suitable cardiovascular agents for use in the buccal sprays of the invention include , but are not limited to , edaravone , iloprost , levosimendan , molsidomine , tezosentan , tirilazad , ym087 , adenosine , avasimibe , fenofibrate , and mixtures thereof . in one embodiment the active compound is a plaque stabilization agent . a suitable plaque stabilization agent for use in the buccal sprays of the invention includes , but is not limited to , avasimibe . in one embodiment the active compound is a vasodilator . suitable vasodilators for use in the buccal sprays of the invention include , but are not limited to , buflomedil , cilostazol , dipyridamole , diazoxide , hydralazine , minoxidil , naftidrofuryl , nicorandil , nitroprusside , alprostadil , apomorphine , phentolamine mesylate , sildenafil , tadalafil , vardenifil , and mixtures thereof . in one embodiment the active compound is an anti - anginal . suitable anti - anginals for use in the buccal sprays of the invention include , but are not limited to , amilodipine , amyl nitrite , atenolol , bepridil , diltiazem , erythrityl tetranitrate , felodipine , isosorbide dinitrate , isradipine , metoprolol , nadolol , nicardipine , nifedipine , nimodipine , pentaerythritol tetranitrate , propranolol , and mixtures thereof . in one embodiment the active compound is an anti - coagulant . suitable anti - coagulants for use in the buccal sprays of the invention include , but are not limited to , abeiximab , ardeparin , argatroban , bivalirudin , clopidogrel , dalteparin , danaparoid , desirudin , dipyridamole , enoxaparin , eptifibatide , fondaparinux , h376 / 95 , lepirudin , melagatran , nadroparine , nafamostat mesilate , pentosan , pentoxifylline , reviparin , sarpogrelate , snac / snad - heparin , ticlopidine , tinzaparin , tirofiban , warfarin , and mixtures thereof . in one embodiment the active compound is an anti - hypotensive . suitable anti - hypotensives for use in the buccal sprays of the invention include , but are not limited to , midodrine , dobutamine , fludrocortisone , and mixtures thereof . in one embodiment the active compound is an anti - thrombotic . suitable anti - thrombotics for use in the buccal sprays of the invention include , but are not limited to , aspirin , abciximab , enoxaparin , integrelin , ticlopidine , and mixtures thereof . in one embodiment the active compound is a drug for treating congestive heart failure . suitable drugs for treating congestive heart failure for use in the buccal sprays of the invention include , but are not limited to , amrinone , benazepril , bumetanide , captopril , digitoxin , digoxin , dobutamine , dopamine , enalapril , ethacrynic acid , fosinopril , furosemide , hydralazine , lisinopril , mihinone , minoxidil , moexipril , quinapril , ramipril , torsemide , and mixtures thereof . in one embodiment the active compound is a p - fox inhibitor . a suitable p - fox inhibitor for use in the buccal sprays of the invention includes , but is not limited to , ranolazine . the formulations of the present invention comprise an active compound or a pharmaceutically acceptable salt thereof . the term “ pharmaceutically acceptable salts ” refers to salts prepared from pharmaceutically acceptable non - toxic acids or bases including organic and inorganic acids or bases . when an active compound of the present invention is acidic , salts may be prepared from pharmaceutically acceptable non - toxic bases . salts derived from all stable forms of inorganic bases include aluminum , ammonium , calcium , copper , iron , lithium , magnesium , manganese , potassium , sodium , zinc , etc . particularly preferred are the ammonium , calcium , magnesium , potassium , and sodium salts . salts derived from pharmaceutically acceptable organic non - toxic bases include salts of primary , secondary , and tertiary amines , substituted amines including naturally occurring substituted amines , cyclic amines and basic ion - exchange resins such as arginine , betaine , caffeine , choline , n , n dibenzylethylenediamine , diethylamine , 2 - diethylaminoethanol , 2 - dimethyl - aminoethanol , ethanolamine , ethylenediamine , n - ethylmorpholine , n - ethylpiperidine , glucamine , glucosamine , histidine , isopropylamine , lysine , methyl - glucosamine , morpholine , piperazine , piperidine , polyamine resins , procaine , purine , theobromine , triethylamine , trimethylamine , tripropylamine , etc . when an active compound of the present invention is basic , salts may be prepared from pharmaceutically acceptable non - toxic acids . such acids include acetic , benzenesulfonic , benzoic , camphorsulfonic , citric , ethane - sulfonic , fumaric , gluconic , glutamic , hydrobromic , hydrochloric , isethionic , lactic , maleic , mandelic , methanesulfonic , mucic , nitric , pamoic , pantothenic , phosphoric , succinic , sulfuric , tartaric , p - toluenesulfonic , etc . particularly preferred are citric , hydrobromic , maleic , phosphoric , sulfuric , and tartaric acids . in the discussion of methods of treatment herein , reference to the active compounds is meant to also include the pharmaceutically acceptable salts thereof . while certain formulations are set forth herein , the actual amounts to be administered to the mammal or man in need of same are to be determined by the treating physician . the invention is further defined by reference to the following examples , which are intended to be illustrative and not limiting . the following are examples of certain classes . all values unless otherwise specified are in weight percent . cns active amines and their salts : including but not limited to tricyclic amines , gaba analogues , thiazides , phenothiazine derivatives , serotonin antagonists and serotonin reuptake inhibitors
buccal aerosol sprays or capsules using polar and non - polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa , resulting in fast onset of effect . the buccal polar compositions of the invention comprise formulation i : aqueous polar solvent , active compound , and optional flavoring agent ; formulation ii : aqueous polar solvent , active compound , optionally flavoring agent , and propellant ; formulation iii : non - polar solvent , active compound , and optional flavoring agent ; and formulation iv : non - polar solvent , active compound , optional flavoring agent , and propellant .