referring now to the drawings , which are provided by way of example and not limitation , there is shown a compact electrokinetic stimulator . stimulation of the median nerve at the ventral portion of the wrist is well documented for the prevention of postoperative nausea and vomiting . existing nerve stimulators that are employed in operating rooms to stimulate the median nerve at this location can be lacking . the problems with such apparatus are lack of uniformity among nerve stimulators , bulk of the equipment , lack of portability and disposability and cost of the equipment . accordingly , the present disclosure is offered as a solution to problems that hinder wider application of nerve stimulation . one application of the nerve stimulator of the present disclosure is to the anterior tibial nerve to treat urinary urgency . other applications are also contemplated . moreover , application of a disposable stimulator on the median nerve can facilitate the prevention of nausea in various settings such as postoperative , chemotherapy , pregnancy as well as other etiologies not otherwise specified . one contemplated location to access the median nerve is at the ventral wrist . the disposable nature of the device allows the device to travel with the patient thus preventing reactivation of the chemoreceptors trigger zone which may prevent nausea that occurs after discharge from the recovery room . it should be noted that the described treatment aids in the alleviation of the symptoms of nausea but does not treat the underlying etiology . in addition to use of the device in a preemptive protocol , the nerve stimulator may be used to treat persons experiencing postoperative nausea and vomiting or nausea from other etiologies with a rescue protocol , and may be used to stimulate nerves other than the median nerve as well . oscilloscopic analysis was conducted on a circuit that was being applied to the median nerve region while it was being stimulated with a 1 . 5 to 5 ma current . the alternating pulse and ramp functions applied by the stimulator were of low enough voltage to consider it feasible to use small battery technology as an alternative power supply . a microchip is contemplated to be sufficient to run the algorithms required to provide nerve stimulation that regulates the current to approximate a target value of 1 . 5 to 5 ma with a frequency of 2 hz . as shown in fig1 - 3 , the nerve stimulization device 100 of the present disclosure includes a flexible plastic tape or cover 102 with two adhesive ekg style electrode assemblies 104 . the nerve stimulator can act as a acustimulator device . the device can be relatively small being approximately 1 . 5 inches wide and about 3 inches long . a microchip and miniature circuit board 106 can be mounted between the two electrodes 104 as shown in the figures . activation of the device 100 can be accomplished by pulling or removing a pull tab ( not shown ) that would complete the circuit with the power cells . a led light 108 can be configured to flash when a current is detected . alternatively , a magnetic wand ( not shown ) can be employed to start the circuit and set it to operate for either 8 or 16 hours ( with a second touch of the wand , or to the end of battery life ). a pulse generator powered by a battery 109 and controlled by the microchip 106 can deliver 1 . 5 to 5 milliamperes of current at 2 hz . the battery 109 and microchip 106 cooperate to form a pulse generator assembly . furthermore , this assembly can be configured to detect impedance of skin to insure that the desired amperage is delivered . as best seen in fig2 b and 2c , a top portion 112 of the stimulator device 100 can be formed of a foam material . a bottom portion of the device is contemplated to embody a foam insulation . wires 116 extend from the pulse generator assembly to each electrode assembly 104 . further , an energy transmitting gel 120 is associated with each electrode assembly 104 to facilitate a desired contact with the patient . an adhesive 130 can also be incorporated into the bottom surface of the device 100 for attachment to the target location on the patient &# 39 ; s body . extended operation of up to 76 hours is also contemplated . thus , a battery is chosen to provide up to or more than 76 hours of operation . prior to assembly , the microchip 106 can be “ stamped ” with a control algorithm that is housed and delivered by a dedicated laptop computer . the device 100 can be evaluated using a circuit load that simulates the impedance of the median nerve region 200 . this evaluation can record the applied current and voltage wave forms and the frequency of application . multiple rounds of evaluation can be conducted to verify circuit performance . use of various wave forms may provide enhanced effectiveness . one aspect is the long term use of the device following surgery . most conventional peripheral stimulation does not last 10 - 20 hours . accordingly , one contemplated approach is employing a balanced waveform that avoids the net buildup of ions ( polarization ). other waveforms are contemplated to specifically avoid side effects . yet another waveform issue for long term stimulation is the speed with which the peak current is applied to the patient . thus , a waveform characterized by a gentle slope to this build up is also contemplated . in one embodiment , it is contemplated that the wave form that will be employed can be characterized as a box wave form at a 5 ma current and a frequency of 2 hz . use of the device alone provides an estimate fifty percent reduction in postoperative nausea and vomiting . in conjunction with a single prophylactic dose of intravenous ondansetron 4 mg on emergence should offer results superior to either intervention alone . the patient continues to use the device for up to 76 hours or to end of battery life . elements of a rescue protocol include hydration and administration of fast acting agents capable of breaking the nausea and vomiting cycle with application of the acustimulator . in the postoperative care setting with the patient being monitored , administration of 10 mg of intravenous propofol and 6 . 25 to 25 mg of intravenous promethazine is performed along with the application of the acustimulator . in one treatment protocol , a first step involves an assessment of the patient . a patient history is taken and a physical is performed . it is recognized that nausea and vomiting risk stratification is multifactored and a patient &# 39 ; s condition must be assessed in order to arrive at the first preventative treatment . thus , a patient &# 39 ; s entire health and treatment history is reviewed and key aspects are noted and weighed . additionally , the type of procedure that the patient is about to undergo is also assessed and analyzed as is the anesthesia that will be used in the procedure . for example , it is noted whether a pelvic region or an intrabdominal procedure is to be conducted . also surgical patients can be stratificated as to low , medium and high risk . it is to be recognized that for low risk procedures , for example minor skin procedures or radiologic procedures , an anesthetic technique that minimizes nausea such as a total intravenous anesthetic ( tiva ) technique using propofol is contemplated . moderate risk procedures such as those applicable in distal extremity orthopedic procedures would utilize the disclosed stimulation device along with a tiva and an additional antiemetic such as ondansetron . high risk procedures such as those associated with intra - abdominal or pelvic surgery would utilize the stimulation device , tiva and two or more additional antiemeitics such as ondansetron and dexamethasone . separate specific considerations can be important where the patient is undergoing emetogenic chemotherapy . it is noted that some chemotherapeutic agents are much more emetogenic than others . as well , dosage and timing frequency and inter - patient variables can impact the probability and severity of nausea . thus , the routine antiemetic therapy should be given and the stimulation device should be placed and activated , just before infusion of chemotherapy begins . moreover , distinct protocols may be necessary when treating nausea and vomiting associated with pregnancy and labor . such patients may require a different approach due to limitations of systemic antiemetics used during pregnancy . median nerve acustimulation is nonpharmacologic therefore avoids potential risk associated with systemic pharmacologic agents . treating patients suffering from motion sickness can involve other considerations . for example , it may be necessary to consider over - the - counter availability of motion sickness or nausea medications . thus , a protocol combining the stimulation device with available otc antiemetics such as dimenhydrinate can lead to a successful treatment . in general , the treatment of nausea , is intended to be multimodal in nature . thus , the application of nerve stimulation in conjunction with the administration of an antiemetic is contemplated . for a low risk patient in a method for treating nausea , the stimulization device 100 is attached to the patient at a ventral portion of the wrist above the median nerve . the device 100 is activated ideally within 60 minutes and with the patient in a supine or semi - recombinant position prior to induction of anesthesia . the device 100 is permitted to operate until depletion of the battery . in treating a medium risk patient for nausea , the acustimulator device 100 is applied to the ventral portion of the wrist above the median nerve for example , and is activated within 60 minutes prior to the induction of the anesthesia . again , here , the device 100 is permitted to operate until the depletion of the battery . in addition , 30 minutes prior to the emergence of anesthesia , 4 mg of ondansetron is administered to the patient intravenously . for a high risk patient , the acustimulator device 100 is applied as before and 4 mg of ondansetron is administered . additionally , 4 to 8 mg of dexamethasone is administered to the patient intravenously after the induction of anesthesia . the patient is also assessed to determine whether a scopolamine patch and / or an oral dose of aprepitant 40 mg should be given to the patient prior to induction of anesthesia . moreover , in the perioperative period , there are other considerations . these include maintenance of normovolemia by administration of intravenous fluids , and minimizing iv or oral opiates as these medications commonly cause nausea and regional anesthesia when appropriate . for example , utilizing peripheral nerve blocks for orthopedic procedures on the upper and lower extremities or epidural blocks for thoracic , abdominal , pelvic or lower extremity procedures can be appropriate in a treatment scheme . where a patient is undergoing chemotherapy , one approach to nausea treatment would be to apply the acustimulator device 100 to stimulate the median nerve 30 to 60 minutes prior to the infusion of emetogenic chemotherapy along with standard current anti - emetics . the device 100 would then be employed continuously until battery depletion . it is also contemplated that the acustimulator device 100 can be equipped to receive replacement batteries . in this way , continued treatment for the prevention of nausea can be performed such as that might be necessary during pregnancy . the device 100 would be applied to stimulate the median nerve at early signs of pregnancy induced nausea , for example , and allowed to work until battery depletion . a new battery can then be inserted into the device 100 when new signs of nausea begin to appear after a last round of treatment . it is further contemplated that a transdermal antiemetic such as scopolamine can be contained within the adhesive portion of the stimulation device . the antiemetic can be placed inside or outside the field of stimulation energy . in one application the drug can be delivered utilizing ionophoretic technology for transdermal delivery of anti - emetic agent ( s ). other transdermal delivery technologies are contemplated . the approach of combining median nerve accustimulation and a transdermal anti - emetic in a single contained disposable unit as multimodal therapy is contemplated . accordingly , the present disclosure is intended to address postoperative symptoms such as nausea . thus , it will be apparent from the foregoing that , while particular forms of the invention have been illustrated and described , various modifications can be made without parting from the spirit and scope of the invention .
a device and method for stimulating nerves . in one application , the approaches treat nausea and vomiting caused by a reaction to general anesthesia . a bi - modal approach involving acustimulation and medicants is contemplated for specific conditions .