the present invention encompasses a multimodality technique , method , and apparatus for the treatment of several diseases , including but not limited to obesity , eating disorders , depression , epilepsy , and diabetes . these modalities may be used for diagnostic and therapeutic uses , and these modalities include but are not limited to stimulation of gastric tissue , stimulation of gastric musculature , stimulation of gastric neural tissue , stimulation of sympathetic nervous tissue , stimulation of parasympathetic nervous tissue , stimulation of peripheral nervous tissue , stimulation of central nervous tissue , stimulation of cranial nervous tissue , stimulation of skin receptors , including pacinian corpuscles , nociceptors , golgi tendons , and other sensory tissues in the skin , subcutaneous tissue , muscles , and joints . stimulation may be accomplished by electrical means , optical means , electromagnetic means , radiofrequency means , electrostatic means , magnetic means , vibrotactile means , pressure means , pharmacologic means , chemical means , electrolytic concentration means , thermal means , or other means for altering tissue activity . already encompassed in the above description are several specific applications of this broad technology . these specific applications include electrical stimulation of gastric tissue , including at least one of muscle and neural , for the control of appetite and satiety , and for the treatment of obesity . additional specific uses include electrical stimulation of gastric tissue for the treatment of depression . further uses include electrical stimulation of pancreatic tissue for the treatment of diabetes . a . satiety modulation . a1 . sympathetic afferent stimulation . selected stimulation of the sympathetic nervous system is an objective of the present invention . a variety of modulator designs and configurations are included in the present invention and other designs and configurations may be apparent to those skilled in the art and these are also included in the present invention . said modulator may take the form of electrode or electrical source , optical source , electromagnetic source , radiofrequency source , electrostatic source , magnetic source , vibrotactile source , pressure source , pharmacologic source , chemical source , electrolyte source , thermal source , or other energy or stimulus source . one objective of the modulator design for selective sympathetic nervous system stimulation is the avoidance of stimulation of the vagus nerve . stimulation of the vagus nerve poses the risk enhanced propensity for development of gastric or duodenal ulcers . other techniques in which electrical stimulation has been used for the treatment of obesity have included stimulation of central nervous system structures or peripheral nervous system structures . other techniques have used sequential stimulation of the gastric tissue to interrupt peristalsis ; however , this broad stimulation of gastric tissue necessarily overlaps regions heavily innervated by the vagus nerve and consequently poses the same risks of gastric and duodenal ulcers that stimulation of the vagus nerve does . one objective of the present invention is the selective stimulation of said afferent neural fibers that innervate gastric tissue . avoidance of vagus nerve stimulation is an object of this modulator configuration . other alternative approaches to gastric pacing involving gastric muscle stimulation secondarily cause stimulation of the vagus nerve as well as stimulation of gastric tissues in acid - secreting regions , consequently posing the undesirable side effects of gastric and duodenal ulcers secondary to activation of gastric acid stimulation . there are a number of approaches to selective stimulation of the sympathetic nervous system . this invention includes stimulation of the sympathetic fibers at sites including the zones of innervation of the stomach , the gastric innervation zones excluding those innervated by vagus branches , the distal sympathetic branches proximal to the stomach , the sympathetic trunk , the intermediolateral nucleus , the locus ceruleus , the hypothalamus , and other structures comprising or influencing sympathetic afferent activity . stimulation of the sympathetic afferent fibers elicits the perception of satiety , and achievement of chronic , safe , and efficacious modulation of sympathetic afferents is one of the major objectives of the present invention . alternating and augmenting stimulation of the sympathetic nervous system and vagus nerve is included in the present invention . by alternating stimulation of the vagus nerve and the sympathetic afferent fibers , one may induce the sensation of satiety in the implanted patient while minimizing the potential risk for gastric and duodenal ulcers . since vagus and sympathetic afferent fibers carry information that is related to gastric distention , a major objective of the present invention is the optimization stimulation of the biggest fibers , the afferent sympathetic nervous system fibers , and other afferent pathways such that a maximal sensation of satiety is perceived in the implanted individual and such that habituation of this sensation of satiety is minimized . this optimization is performed in any combination of matters including temporal patterning of the individual signals to each neural pathway , including but not limited to the vagus nerve and sympathetic afferents , as well as temporal patterning between a multiplicity of stimulation channels involving the same were neural pathways the present invention teaches a multiplicity of apparatus and method for stimulation of afferent sympathetic fibers , as detailed below . other techniques and apparatus may become apparent to those skilled in the art , without departing from the present invention . a1a . sympathetic afferents — gastric region . fig1 through fig3 demonstrate stimulation of gastric tissue , including at least one of neural and muscular tissue . anatomical structures include esophagus 15 , lower esophageal sphincter 14 , stomach 8 , cardiac notch of stomach 16 , gastric fundus 9 , greater curvature of stomach 10 , pyloric antrum 11 , lesser curvature of stomach 17 , pylorus 12 , and duodenum 13 . implantable pulse generator 1 is shown with modulator 2 and modulator 3 in contact with the corresponding portion of stomach 8 in the respective figures , detailed below . implantable pulse generator further comprises attachment fixture 4 and attachment fixture 5 . additional or fewer attachment fixtures may be included without departing from the present invention . attachment means 6 and attachment means 7 are used to secure attachment fixture 4 and attachment fixture 5 , respectively to appropriate portion of stomach 8 . attachment means 6 and attachment means 7 may be comprised from surgical suture material , surgical staples , adhesives , or other means without departing from the present invention . fig1 , 2 , and 3 show implantable pulse generator 1 in several anatomical positions . in fig1 , implantable pulse generator 1 is shown positioned along the superior region of the greater curvature of stomach 10 , with modulator 2 and modulator 3 in contact with the tissues comprising the greater curvature of stomach 10 . in fig2 , implantable pulse generator 1 is shown positioned along the inferior region of the greater curvature of stomach 10 , with modulator 2 and modulator 3 in contact with the tissues comprising the greater curvature of stomach 10 . in fig3 , implantable pulse generator 1 is shown positioned along the pyloric antrum 11 , with modulator 2 and modulator 3 in contact with the tissues comprising the pyloric antrum 11 . modulator 2 and modulator 3 are used to stimulate at least one of gastric longitudinal muscle layer , gastric circular muscle layer , gastric nervous tissue , or other tissue . modulator 2 and modulator 3 may be fabricated from nonpenetrating material or from penetrating material , including needle tips , arrays of needle tips , wires , conductive sutures , other conductive material , or other material , without departing from the present invention . a1b . sympathetic afferents — sympathetic trunk . the present invention teaches apparatus and method for stimulation of sympathetic afferent fibers using stimulation in the region of the sympathetic trunk . as shown in fig1 , 15 , and 16 , sympathetic trunk neuromodulatory interface 83 and 85 , positioned on right sympathetic trunk 71 , and sympathetic trunk neuromodulatory interface 85 , 86 positioned on left sympathetic trunk 72 , are used to provide stimulation for afferent as well as for efferent sympathetic nervous system modulation . modulation of efferent sympathetic nervous system is discussed below , and this is used for metabolic modulation . a1c . sympathetic afferents — other . the present invention teaches apparatus and method for stimulation of sympathetic afferent fibers using stimulation of nerves arising from the sympathetic trunk . as shown in fig1 , 15 , and 16 , thoracic splanchnic neuromodulatory interface 87 , 89 , 88 , and 90 , positioned on right greater splanchnic nerve 73 , right lesser splanchnic nerve 75 , left greater splanchnic nerve 74 , left lesser splanchnic nerve 76 , respectively , and are used to provide stimulation for afferent as well as for efferent sympathetic nervous system modulation . modulation of efferent sympathetic nervous system is discussed below , and this is used for metabolic modulation . a2 . gastric musculature stimulation . a further object of the present invention is the stimulation of the gastric musculature . this may be performed using either or both of closed loop and open loop control . in the present embodiment , a combination of open and closed loop control is employed . the open loop control provides a baseline level of gastric stimulation . this stimulation maintains tone of the gastric musculature . this increases the wall tension the stomach and plays a role in the perception of satiety in the implanted patient . additionally , stimulation of the gastric musculature causes contraction of the structures , thereby reducing the volume of the stomach . this gastric muscle contraction , and the consequent reduction of stomach volume effectively restricts the amount of food that may be ingested . surgical techniques have been developed and are known to those practicing in the field of surgical treatment of obesity . several of these procedures are of the restrictive type , but because of their surgical nature they are fixed in magnitude and difficult if not impossible to reverse . the present invention teaches a technique which employs neural modulation and gastric muscle stimulation which by its nature is the variable and reversible . this offers the advantages postoperative adjustment of magnitude , fine tuning for the individual patient , varying of magnitude to suit the patient &# 39 ; s changing needs and changing anatomy over time , and the potential for reversal or termination of treatment . furthermore , since the gastric wall tension is generated in a physiological manner by the muscle itself , it does not have the substantial risk of gastric wall necrosis and rupture inherent in externally applied pressure , as is the case with gastric banding . fig1 , 2 , and 3 depict placements of the implantable pulse generator 1 that may be used to stimulate gastric muscle tissue . stimulation of both longitudinal and circular muscle layers is included in the present invention . stimulation of gastric circular muscle layer causes circumferential contraction of the stomach , and stimulation of gastric longitudinal muscle layer causes longitudinal contraction of the stomach . this muscle stimulation and contraction accomplishes several objectives : ( 1 ) functional reduction in stomach volume , ( 2 ) increase in stomach wall tension , ( 3 ) reduction in rate of food bolus flow . all of these effects are performed to induce the sensation of satiety . a3 . gastric pylorus stimulation . fig4 depicts implantable pulse generator 1 positioned to perform stimulation of the gastric pylorus 12 to induce satiety by restricting outflow of food bolus material from the stomach 8 into the duodenum 13 . stimulation of the pylorus 12 may be continuous , intermittent , or triggered manually or by sensed event or physiological condition . fig4 depicts implantable pulse generator 1 positioned adjacent to the gastric pylorus 12 ; this position provides secure modulator positioning while eliminating the risk of modulator and wire breakage inherent in other designs in which implantable pulse generator 1 is positioned remote from the gastric pylorus 12 . fig5 depicts implantable pulse generator 1 positioned to perform stimulation of the gastric pylorus 12 to induce satiety by restricting outflow of food bolus material from the stomach 8 into the duodenum 13 . stimulation of the pylorus 12 may be continuous , intermittent , or triggered manually or by sensed event or physiological condition . fig5 depicts implantable pulse generator 1 attached to stomach 8 , specifically by the pyloric antrum 11 ; this position facilitates the use of a larger implantable pulse generator 1 . the risk of modulator and wire breakage is minimized by the use of appropriate strain relief and stranded wire designs . a4 . parasympathetic stimulation . the parasympathetic nervous system is complementary to the sympathetic nervous system and plays a substantial role in controlling digestion and cardiac activity . several routes are described in the present invention to modulate activity of the parasympathetic nervous system . a4a . parasympathetic stimulation — vagus nerve . others have advocated the use of vagus nerve stimulation for the treatment of a number of disorders including obesity . zabara and others have described systems in which the vagus nerve in the region of the neck is stimulated . this is plagued with a host of problems , including life - threatening cardiac complications as well as difficulties with speech and discomfort during stimulation . the present invention is a substantial advance over that discussed by zabara et al , in which unrestricted fiber activation using epineural stimulation is described . that technique results in indiscriminate stimulation of efferent and afferent fibers . with vagus nerve stimulation , efferent fiber activation generates many undesirable side effects , including gastric and duodenal ulcers , cardiac disturbances , and others . in the present invention , as depicted in fig1 , vagus neuromodulatory interface 97 and 98 are implanted adjacent to and in communication with right vagus nerve 95 and left vagus nerve 96 . the neuromodulatory interface 97 and 98 overcomes these limitations that have persisted for over a decade with indiscriminate vagus nerve stimulation , by selectively stimulating afferent fibers of the at least one of the vagus nerve , the sympathetic nerves , and other nerves . the present invention includes the selective stimulation of afferent fibers using a technique in which electrical stimulation is used to block anterograde propagation of action potentials along the efferent fibers . the present invention includes the selective stimulation of afferent fibers using a technique in which stimulation is performed proximal to a nerve transection and in which the viability of the afferent fibers is maintained . one such implementation involves use of at least one of neuromodulatory interface 34 which is of the form shown in at least one of longitudinal electrode neuromodulatory interface 118 , longitudinal electrode regeneration port neuromodulatory interface 119 , regeneration tube neuromodulatory interface 120 , or other design in which a subset of the neuronal polulaiton is modulated . a . 4 . a . i . innovative stimulation anatomy . fig6 depicts multimodal treatment for the generation of satiety , using sympathetic stimulation , gastric muscle stimulation , gastric pylorus stimulation , and vagus nerve stimulation . this is described in more detail below . modulators 30 and 31 are positioned in the general region of the lesser curvature of stomach 17 . stimulation in this region results in activation of vagus nerve afferent fibers . stimulation of other regions may be performed without departing from the present invention . in this manner , selective afferent vagus nerve stimulation may be achieved , without the detrimental effects inherent in efferent vagus nerve stimulation , including cardiac rhythm disruption and induction of gastric ulcers . a . 4 . a . ii . innovative stimulation device . the present invention further includes devices designed specifically for the stimulation of afferent fibers . fig7 depicts epineural cuff electrode neuromodulatory interface 117 , one of several designs for neuromodulatory interface 34 included in the present invention . nerve 35 is shown inserted through nerve cuff 36 . for selective afferent stimulation , the nerve 35 is transected distal to the epineural cuff electrode neuromodulatory interface 117 . this case is depicted here , in which transected nerve end 37 is seen distal to epineural cuff electrode neuromodulatory interface 117 . epineural electrode — 49 , 50 , and 51 are mounted along the inner surface of nerve cuff 36 and in contact or close proximity to nerve 35 . epineural electrode connecting wire 52 , 53 , 54 are electrically connected on one end to epineural electrode 49 , 50 , and 51 , respectively , and merge together on the other end to form connecting cable 55 . fig8 depicts longitudinal electrode neuromodulatory interface 118 , one of several designs for neuromodulatory interface 34 included in the present invention . nerve 35 is shown inserted into nerve cuff 36 . for selective afferent stimulation , the nerve 35 is transected prior to surgical insertion into nerve cuff 36 . longitudinal electrode array 38 is mounted within nerve cuff 36 and in contact or close proximity to nerve 35 . connecting wire array 40 provides electrical connection from each element of longitudinal electrode array 38 to connecting cable 55 . nerve cuff end plate 41 is attached to the distal end of nerve cuff 36 . nerve 35 may be advanced sufficiently far into longitudinal electrode array 38 such that elements of longitudinal electrode array — 38 penetrate into nerve 35 . alternatively , nerve 35 may be placed with a gap between transected nerve end 37 and longitudinal electrode array 38 such that neural regeneration occurs from transected nerve end 37 toward and in close proximity to elements of longitudinal electrode array 38 . fig9 depicts longitudinal electrode regeneration port neuromodulatory interface 119 , an improved design for neuromodulatory interface 34 included in the present invention . nerve 35 is shown inserted into nerve cuff 36 . for selective afferent stimulation , the nerve 35 is transected prior to surgical insertion into nerve cuff 36 . longitudinal electrode array 38 is mounted within nerve cuff 36 and in contact or close proximity to nerve 35 . connecting wire array 40 provides electrical connection from each element of longitudinal electrode array 38 to connecting cable 55 . nerve cuff end plate 41 is attached to the distal end of nerve cuff 36 . nerve 35 may be advanced sufficiently far into longitudinal electrode array 38 such that elements of longitudinal electrode array 38 penetrate into nerve 35 . alternatively , nerve 35 may be placed with a gap between transected nerve end 37 and longitudinal electrode array 38 such that neural regeneration occurs from transected nerve end 37 toward and in close proximity to elements of longitudinal electrode array 38 . at least one of nerve cuff 36 and nerve cuff end plate 41 are perforated with one or a multiplicity of regeneration port 39 to facilitate and enhance regeneration of nerve fibers from transected nerve end 37 . fig1 depicts regeneration tube neuromodulatory interface 120 , an advanced design for neuromodulatory interface 34 included in the present invention . nerve 35 is shown inserted into nerve cuff 36 . for selective afferent stimulation , the nerve 35 is transected prior to surgical insertion into nerve cuff 36 . regeneration electrode array 44 is mounted within regeneration tube array 42 , which is contained within nerve cuff 36 . each regeneration tube 43 contains at least one element of regeneration electrode array 44 . each element of regeneration electrode array 44 is electrically connected by at least one element of connecting wire array 40 to connecting cable 55 . nerve 35 may be surgically inserted into nerve cuff 36 sufficiently far to be adjacent to regeneration tube array 42 or may be placed with a gap between transected nerve end 37 and regeneration tube array 42 . neural regeneration occurs from transected nerve end 37 toward and through regeneration tube 43 elements regeneration tube array 42 . the present invention further includes stimulation of other tissues that influence vagus nerve activity . these include tissues of the esophagus , stomach , small and large intestine , pancreas , liver , gallbladder , kidney , mesentery , appendix , bladder , uterus , and other intraabdominal tissues . stimulation of one or a multiplicity of these tissues modulates activity of the vagus nerve afferent fibers without significantly altering activity of efferent fibers . this method and the associated apparatus facilitates the stimulation of vagus nerve afferent fibers without activating vagus nerve efferent fibers , thereby overcoming the ulcerogenic and cardiac side effects of nonselective vagus nerve stimulation . this represents a major advance in vagus nerve modulation and overcomes the potentially life - threatening complications of nonselective stimulation of the vagus nerve . a4b . parasympathetic stimulation — other . the present invention teaches stimulation of the cervical nerves or their roots or branches for modulation of the parasympathetic nervous system . additionally , the present invention teaches stimulation of the sacral nerves or their roots or branches for modulation of the parasympathetic nervous system . a5 . multichannel satiety modulation . fig6 depicts apparatus and method for performing multichannel modulation of satiety . implantable pulse generator 1 is attached to stomach 8 , via attachment means 6 and 7 connected from stomach 8 to attachment fixture 4 and 5 , respectively . implantable pulse generator 1 is electrically connected via modulator cable 32 to modulators 24 , 25 , 26 , 27 , 28 , and 29 , which are affixed to the stomach 8 preferably along the region of the greater curvature of stomach 10 . implantable pulse generator 1 is additionally electrically connected via modulator cable 33 to modulators 30 and 31 , which are affixed to the stomach 8 preferably along the region of the lesser curvature of stomach 17 . implantable pulse generator 1 is furthermore electrically connected via modulator cable 18 and 19 to modulators 2 and — 3 , respectively , which are affixed to the gastric pylorus 12 . modulator 2 is affixed to gastric pylorus via modulator attachment fixture 22 and 23 , and modulator 3 is affixed to gastric pylorus via modulator attachment fixture 20 and 21 . using the apparatus depicted in fig6 , satiety modulation is achieved through multiple modalities . a multiplicity of modulators , including modulator 30 and 31 facilitate stimulation of vagus and sympathetic afferent fibers directly , as well as through stimulation of tissues , including gastric muscle , that in turn influence activity of the sympathetic and vagus afferent fibers . a multiplicity of modulators , including modulator 24 , 25 , 26 , 27 , 28 , and 29 facilitate stimulation of sympathetic afferent fibers directly , as well as through stimulation of tissues , including gastric muscle , that in turn influence activity of the sympathetic fibers . any of these modulators may be used to modulate vagus nerve activity ; however , one advancement taught in the present invention is the selective stimulation of sympathetic nerve fiber activation , and this is facilitated by modulators 24 , 25 , 26 , 27 , 28 , and 29 , by virtue of their design for and anatomical placement in regions of the stomach 8 that are not innervated by the vagus nerve or its branches . in addition to the apparatus and methods depicted in fig6 for satiety modulation , the present invention further includes satiety modulation performed with the apparatus depicted in fig1 , and described previously , using stimulation of right sympathetic trunk 71 , left sympathetic trunk 72 , right greater splanchnic nerve 73 , left greater splanchnic nerve 74 , right lesser splanchnic nerve 75 , left lesser splanchnic nerve 76 or other branch or the sympathetic nervous system . b . metabolic modulation b . 1 . sympathetic efferent stimulation . one objective of the modulator configuration employed in the present invention is the selected stimulation of sympathetic efferent nerve fibers . the present invention includes a multiplicity of potential modulator configurations and combinations of thereof . the present embodiment includes modulators placed at a combination of sites to interface with the sympathetic efferent fibers . these sites include the musculature of the stomach , the distal sympathetic branches penetrating into the stomach , postganglionic axons and cell bodies , preganglionic axons and cell bodies , the sympathetic chain and portions thereof , the intermediolateral nucleus , the locus ceruleus , the hypothalamus , and other structures comprising or influencing activity of the sympathetic nervous system . stimulation of the sympathetic efferents is performed to elevate the metabolic rate and lipolysis in the adipose tissue , thereby enhancing breakdown of fat and weight loss in the patient . b . 1 . a . sympathetic efferent stimulation sympathetic trunk . fig1 , 15 , and 16 depict apparatus for stimulation of the sympathetic nervous system . fig1 depicts a subset of anatomical locations for placement of neuromodulatory interfaces for modulation of the sympathetic nervous system . fig1 depicts the same apparatus with the further addition of a set of implantable pulse generator 1 and connecting cables . fig1 depicts the apparatus shown in fig1 with the further addition of gastric modulation apparatus also depicted in fig6 . fig1 reveals the normal anatomy of the thoracic region . trachea 63 is seen posterior to aortic arch 57 . brachiocephalic artery 59 , left common carotid artery — 60 arise from aortic arch 57 , and left subclavian artery 61 arises from the left common carotid artery 60 . right mainstem bronchus 64 and left mainstem bronchus 65 arise from trachea 63 . thoracic descending aorta 58 extends from aortic arch 57 and is continuous with abdominal aorta 62 . right vagus nerve 95 and left vagus nerve 96 are shown . intercostal nerve 69 and 70 are shown between respective pairs of ribs , of which rib 67 and rib 68 are labeled . right sympathetic trunk 71 and left sympathetic trunk are lateral to mediastinum 82 . right greater splanchnic nerve 73 and right lesser splanchnic nerve 75 arise from right sympathetic trunk 71 . left greater splanchnic nerve 74 and left lesser splanchnic nerve 76 arise from left sympathetic trunk 72 . right subdiaphragmatic greater splanchnic nerve 78 , left subdiaphragmatic greater splanchnic nerve 79 , right subdiaphragmatic lesser splanchnic nerve 80 , and left subdiaphragmatic lesser splanchnic nerve 81 are extensions below the diaphragm 77 of the right greater splanchnic nerve 73 , left greater splanchnic nerve 74 , right lesser splanchnic nerve 75 , and left lesser splanchnic nerve 76 , respectively . b . 1 . b . sympathetic efferent stimulation — splanchnics . fig1 depicts multichannel sympathetic modulation implanted with relevant anatomical structures . sympathetic trunk neuromodulatory interface 83 and 85 are implanted adjacent to and in communication with right sympathetic trunk 71 . sympathetic trunk neuromodulatory interface 84 and 86 are implanted adjacent to and in communication with left sympathetic trunk 72 . sympathetic trunk neuromodulatory interface 83 , 84 , 85 , and 86 are implanted superior to their respective sympathetic trunk levels at which the right greater splanchnic nerve 73 , left greater splanchnic nerve 74 , right lesser splanchnic nerve 75 , and left lesser splanchnic nerve 76 , arise , respectively . thoracic splanchnic nerve interface 87 , 88 , 89 , 90 are implanted adjacent to and in communication with the right greater splanchnic nerve 73 , left greater splanchnic nerve 74 , right lesser splanchnic nerve 75 , and left lesser splanchnic nerve 76 , arise , respectively . abdominal splanchnic nerve interface 91 , 92 , 93 , and 94 are implanted adjacent to and in communication with the right subdiaphragmatic greater splanchnic nerve 78 , left subdiaphragmatic greater splanchnic nerve 79 , right subdiaphragmatic lesser splanchnic nerve 80 , and left subdiaphragmatic lesser splanchnic nerve 81 , respectively . stimulation of at least one of right sympathetic trunk 71 , left sympathetic trunk 72 , right greater splanchnic nerve 73 , left greater splanchnic nerve 74 , right lesser splanchnic nerve 75 , and left lesser splanchnic nerve 76 , right subdiaphragmatic greater splanchnic nerve 78 , left subdiaphragmatic greater splanchnic nerve 79 , right subdiaphragmatic lesser splanchnic nerve 80 , and left subdiaphragmatic lesser splanchnic nerve 81 enhances metabolism of adipose tissue . stimulation of these structures may be performed using at least one of electrical energy , electrical fields , optical energy , mechanical energy , magnetic energy , chemical compounds , pharmacological compounds , thermal energy , vibratory energy , or other means for modulating neural activity . fig1 depicts the implanted neuromodulatory interfaces as in fig1 , with the addition of the implanted pulse generators . implantable pulse generator 99 is connected via connecting cable 103 , 105 , 107 , 109 , 115 , to sympathetic trunk neuromodulatory interface 83 and 85 , and thoracic splanchnic neuromodulatory interface 87 and 89 , and vagus neuromodulatory interface 97 , respectively . implantable pulse generator 100 is connected via connecting cable 104 , 106 , 108 , 110 , 116 , to sympathetic trunk neuromodulatory interface 83 and 85 , and thoracic splanchnic neuromodulatory interface 88 and 90 , and vagus neuromodulatory interface 98 , respectively . implantable pulse generator 101 is connected via connecting cable 111 and 113 to abdominal splanchnic neuromodulatory interface 91 and 93 , respectively . implantable pulse generator 102 is connected via connecting cable 112 and 114 to abdominal splanchnic neuromodulatory interface 92 and 94 , respectively . b . 1 . c . sympathetic efferent stimulation — spinal cord . fig1 and 18 depicts the normal cross sectional anatomy of the spinal cord 151 and anatomy with implanted neuromodulatory interfaces , respectively . fig1 depicts the normal anatomical structures of the spinal cord 151 , including several of its component structures such as the intermediolateral nucleus 121 , ventral horn of spinal gray matter 141 , dorsal horn of spinal gray matter 142 , spinal cord white matter 122 , anterior median fissure 123 . other structures adjacent to or surrounding spinal cord 151 include ventral spinal root 124 , dorsal spinal root 125 , spinal ganglion 126 , spinal nerve 127 , spinal nerve anterior ramus 128 , spinal nerve posterior ramus 129 , gray ramus communicantes 130 , white ramus communicantes — 131 , sympathetic trunk 132 , pia mater 133 , subarachnoid space 134 , arachnoid 135 , meningeal layer of dura mater 136 , epidural space 137 , periosteal layer of dura mater — 138 , and vertebral spinous process 139 , and vertebral facet 140 . fig1 depicts the normal anatomy of the spinal cord seen in transverse section . spinal cord and related neural structures include intermediolateral nucleus 121 , spinal cord white matter 122 , anterior median fissure 123 , ventral spinal root 124 , dorsal spinal root 125 , spinal ganglion 126 , spinal nerve 127 , spinal nerve anterior ramus 128 , spinal nerve posterior ramus 129 , grey ramus communicantes 130 , white ramus communicantes 131 , sympathetic trunk 132 , pia mater 133 , subarachnoid space 134 , arachnoid 135 , meningeal layer of dura 136 , epidural space 137 , periostial layer of dura mater 138 , vertebral spinous process 139 , vertebral facet 140 , ventral horn of spinal gray matter 141 , and dorsal horn of spinal gray matter 142 . fig1 depicts the spinal neuromodulatory interfaces positioned in the vicinity of spinal cord 151 . neuromodulatory interfaces positioned anterior to spinal cord 151 include anterior central spinal neuromodulatory interface 143 , anterior right lateral spinal neuromodulatory interface 144 , and anterior left lateral spinal neuromodulatory interface 145 . neuromodulatory interfaces positioned posterior to spinal cord 151 include posterior central spinal neuromodulatory interface 146 , posterior right lateral spinal neuromodulatory interface 147 , and posterior left lateral spinal neuromodulatory interface 148 . neuromodulatory interfaces positioned lateral to spinal cord 151 include right lateral spinal neuromodulatory interface 149 and left lateral spinal neuromodulatory interface 150 . neuromodulatory interfaces positioned within the spinal cord 151 include intermediolateral nucleus neuromodulatory interface — 152 . stimulation , inhibition , or other modulation of the spinal cord 151 is used to modulate fibers of the sympathetic nervous system , including those in the intermediolateral nucleus 121 and efferent and efferent fibers connected to the intermediolateral nucleus 121 . modulation of at least one of portions of the spinal cord — 151 , intermediolateral nucleus 121 , ventral spinal root 124 , dorsal spinal root 125 , spinal ganglion 126 , spinal nerve 127 , gray ramus communicantes 130 , white ramus communicantes 131 and other structures facilitates modulation of activity of the sympathetic trunk 132 . modulation of activity of the sympathetic trunk 132 , in turn , is used to modulate at least one of metabolic activity , satiety , and appetite . this may be achieved using intermediolateral nucleus neuromodulatory interface 152 , placed in or adjacent to the intermediolateral nucleus 121 . the less invasive design employing neuromodulatory interfaces ( 144 , 145 , 146 , 147 , 148 , 149 , 150 ) shown positioned in the in epidural space 137 is taught in the present invention . b . 1 . d . sympathetic efferent stimulation — other . the present invention further includes modulation of all sympathetic efferent nerves , nerve fibers , and neural structures . these sympathetic efferent neural structures include but are not limited to distal sympathetic nerve branches , mesenteric nerves , sympathetic efferent fibers at all spinal levels , rami communicantes at all spinal levels , paravertebral nuclei , prevertebral nuclei , and other sympathetic structures . b . 2 . noninvasive stimulation . the present invention teaches a device for metabolic control using tactile stimulation . tactile stimulation of afferent neurons causes alterations in activity of sympathetic neurons which influence metabolic activity of adipose tissue . the present invention teaches tactile stimulation of skin , dermal and epidermal sensory structures , subcutaneous tissues and structures , and deeper tissues to modulate activity of afferent neurons . this device for metabolic control employs vibratory actuators . alternatively , electrical stimulation , mechanical stimulation , optical stimulation , acoustic stimulation , pressure stimulation , and other forms of energy that modulate afferent neural activity , are used . c . multimodal metabolic modulation . to maximize efficacy while tailoring treatment to minimize side effects , the preferred embodiment includes a multiplicity of treatment modalities , including afferent , efferent , and neuromuscular modulation . afferent signals are generated to simulate satiety . this is accomplished through neural , neuromuscular , and hydrostatic mechanisms . electrical stimulation of the vagus via vagus nerve interface 45 afferents provides one such channel to transmit information to the central nervous system for the purpose of eliciting satiety . electrical stimulation of the sympathetic afferents via sympathetic nerve interface 46 provides another such channel to transmit information to the central nervous system for the purpose of eliciting satiety . electrical stimulation of gastric circular muscle layerln fig1 , multimodal stimulation is depicted , including stimulation of gastric musculature using modulators 2 and 3 , as well as stimulation of afferent fibers of the proximal stump of vagus nerve 47 using vagus nerve modulator 45 and stimulation of afferent fibers of sympathetic nerve branch 48 . in fig1 , expanded multimodal stimulation is depicted , including those modalities shown in fig1 , including stimulation of gastric musculature using modulators 2 and 3 , as well as stimulation of afferent fibers of the proximal stump of vagus nerve 47 using vagus nerve modulator 45 and stimulation of afferent fibers of sympathetic nerve branch 48 , in addition to those modalities shown in fig6 , explained in detail above , including modulation of gastric muscular fibers , sympathetic afferent fibers innervating gastric tissues , and vagus afferent fibers innervating gastric tissues . in fig1 , further expanded multimodal modulation is depicted , including modalities encompassed and described above and depicted in fig1 and fig1 . this includes modulation of gastric muscle fibers , fibers of the sympathetic nerve branch 48 and vagus nerve 47 that innervate gastric tissues , and a multiplicity of structures in the sympathetic nervous system and vagus nerve 47 . e . system / pulse generator design . neuromodulatory interfaces that use electrical energy to modulate neural activity may deliver a broad spectrum of electrical waveforms . one preferred set of neural stimulation parameter sets includes pulse frequencies ranging from 0 . 1 hertz to 1000 hertz , pulse widths from 1 microsecond to 500 milliseconds . pulses are charge balanced to insure no net direct current charge delivery . the preferred waveform is bipolar pulse pair , with an interpulse interval of 1 microsecond to 1000 milliseconds . current regulated stimulation is preferred and includes pulse current amplitudes ranging from 1 microamp to 1000 milliamps . alternatively , voltage regulation may be used , and pulse voltage amplitudes ranging from 1 microvolt to 1000 volts . these parameters are provide as exemplary of some of the range include in the present invention ; variation from these parameter sets are include in the present invention .
a method and apparatus for physiological modulation , including neural and gastrointestinal modulation , for the purposes of treating several disorders , including obesity , depression , epilepsy , and diabetes . the method and apparatus includes chronically implanted neural and neuromuscular modulators , used to modulate the afferent neurons of the sympathetic nervous system to induce satiety . furthermore , the method and apparatus includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure , which induces satiety , and stimulates sympathetic afferent fibers , including those in the sympathetic trunk , splanchnic nerves , and greater curvature of the stomach , to augment the perception of satiety .