the present invention will now be described in detail by reference to the drawing figures , where as like parts as indicated by like reference numerals . [ 0055 ] fig1 shows the first embodiment of the present invention . fig1 shows the longitudinal length of an ett ( 1 ) which may be a conventional adult or pediatric ett . the ett is an elongated hollow tube constructed from a plastic material ( polymer ) or silicone and is approximately 34 cm long if an adult ett and smaller if pediatric . the internal diameter of the tube can vary from 2 . 5 mm to 10 mm and the external diameter could vary from 3 . 5 mm to 13 mm . the thickness of the wall of the tube could vary from 0 . 5 mm to 2 . 0 mm . the tube is a flexible elongated conduit with a concave surface on one side and a convex surface on the opposite side . it &# 39 ; s proximal end is connected to an adapter ( 2 ) which enables it to be connected to an elongated tube of a mechanical ventilator . the distal end has a 4 cm expandable cuff ( 3 ) starting approximately 4 cm from the distal tip and ending approximately 8 cm from the distal tip . in the distal 4 cm of the ett , between the expandable cuff and the distal tip of the ett , there is a pair of oval holes ( 4 ) one each on the opposite surface of the tube facing each other . the size of the holes can vary between 5 mm and 1 cm . a small tube i . e . primary cannulation ( 5 ) of approximately 1 mm diameter runs within the wall on the convex side of the tube ( s ) and is connected to the expandable cuff for inflation and deflation by terminating on the outer surface of the et tube as a 1 mm hole ( 7 ). this tube alternatively can be attached on the outer surface of the tube on the convex side . the primary cannula has a proximal flexible part ( 8 ) which continues outside the main tubular structure of the ett ( 1 ). the flexible part starts at approximately 18 cm from the distal tip of the ett and continues proximally for a few centimeters to terminate into a cuff inflation indicator ( 9 ) and adapter ( 10 ) for a syringe . the connection between the flexible and rigid part of the primary cannula is through an opening on the outer surface of the ett ( 6 ) which is also 1 mm in id . on the lateral surface of the ett starting at the same level as the cannulation for the inflation of the balloon ( 6 ) or at a higher level ( 13 ) there originates another secondary cannula ( 11 ) on the outer surface of the ett that continues within the wall of the ett . the id of this secondary cannulation can vary from 0 . 01 mm to 1 . 25 mm in size . this secondary cannulation continues distally beyond the balloon to terminate as a pinhole opening ( 12 ) at the distal tip of the ett . the course of the secondary cannulation within the wall of ett may be variable and as demonstrated in this figure , it is from the outer surface to the inner surface to terminate at the distal tip of the ett . the secondary cannulation is an extension of a semi - flexible proximal cannula ( 14 ) which is on the outside of the main tubular structure of the ett ( 1 ) without adhering to it just like the flexible part of the primary cannula ( 8 ). the semi - flexible cannula ( 14 ) makes a connection with the secondary cannulation ( 11 ) through an opening ( 13 ) on the outer surface of the ett . the proximal end of the flexible cannula terminates into a metered dose inhaler ( mdi ) adapter ( 15 ); the flexible cannula maybe an extension of mdi adapter or the two may be fused together if made of different materials . the proximal port of the mdi adapter is designed to fit the nozzle of mdi canister . the distal end of the adapter tapers into a cylindrical tube matable to the flexible canula , the two made of different polymers . this assembly enables aerosolized medication from mdi canister to be delivered at the distal tip of the ett on actuation of the canister . the device may include a special syringe , the terminal injection port of which may have a configuration identical to the nozzle of mdi . this would enable the mdi port to be used for delivering any liquid medication to the respiratory system via a manually operated syringe or any pressurized source . the port may include a cap for closure when not in use . [ 0056 ] fig2 shows the longitudinal view of the ett ( 16 ) associated with alternative embodiments of secondary cannulation . the primary cannulation ( 18 ) runs on the convex wall of the ett to terminate as an orifice ( 19 ) on the outer surface . this ett incorporates two secondary cannulations ( 23 and 28 ) as opposed to one shown in fig1 . the two points of origin of the secondary cannulations ( 22 and 27 ) as demonstrated in fig2 . the secondary cannulations may or may not have similar tracts . they are located on the opposite lateral surfaces of the ett and continue distally to terminate as two pinhole orifices ( 24 and 29 ) at the distal tip of the ett . the secondary cannulations ( 23 and 28 ) are extensions of a semi - flexible proximal tubules ( 21 and 26 ) respectively . the flexible tubules are either extensions of the mdi adapters or matable with it as shown in fig1 . also the length of the flexible tubule outside the main tubular structure of ett could be altered as can the length of secondary cannulations in the wall of the ett . there are numerous varieties of plastic materials that may be used to manufacture the endotracheal tubes ( ett &# 39 ; s ); some examples of the same may be — thermoplastics ( polyvinyl chloride , polyethylene , polypropylene ) silicone , teflon , et ; though the one that is most commonly use is polyvinyl chloride ( pvc ). since the differences in the compliance and coefficient of friction of various materials could influence the delivery of aerosol medication , the secondary cannulation could be coextruded using a compound or a polymer different from the one used to manufacture the primary ett . the coextrusion may optimize the physical properties of the secondary lumen and maximize aerosol delivery . examples of some coextrusions may be — pvc and teflon , pvc and polypropylene , pvc and silicone , pvc and polyethylene , etc . ett may be disposable or reusable after sterilization . [ 0058 ] fig3 is the plan view of the most preferred embodiment of our present invention . the detailed description of fig3 and the rationale for this embodiment of ett will become obvious with the explanation outlined below . effective drug delivery is closely related to particle size . larger particles may provide a greater total drug deliver ; however , a uniform distribution of medication in the distal tracheobronchial tree requires particle size distribution in the respirable range (& lt ; 5 microns ). besides particle size , the drug delivery rate and distribution is also a function of the site if aerosol particle generation and the characteristics of the aerosol plume . even though the size of aerosol particles generated in case of a suspension of pulverized powder medication in a liquid propellant is predetermined and is a function of the size of the crushed solid particles of powder medication , the drug delivery rate and distribution will be tremendously affected by the features of secondary cannulation and the terminal orifice at its &# 39 ; tip . the critical features of secondary cannulations are its length , id , shape and orientation / trajectory . the features of the distal orifice are its &# 39 ; location , orientation , shape , and id . all the aforementioned features will also influence the plume geometry , velocity and orientation and hence the distribution of the particles in the distal tracheolbronchial tree . in our invention , the id of the secondary cannulation may be uniform throughout or tapered along the entire length . alternatively , it may be uniform in the proximal part and tapered near the distal part . the id of the secondary lumen may vary from 0 . 01 mm to 1 . 25 mm . the combined length of the secondary cannulation within the wall of the ett and its proximal flexible part may also play a critical role in the total drug delivery . a narrow id of the secondary cannulation is very important for the aerosol medication to reach the distal tip of the secondary cannulation over approximately 25 - 30 cm of length ; however , if the id is too narrow , it may pose resistance to the flow and impede aerosol delivery . another very important factor is the course ( trajectory ) of the secondary lumen in the wall of the ett . the trajectory may be directed from the outer wall to the inner wall ; alternatively the secondary lumen may stay closer to the outer wall throughout ; it may stay closer to the inner wall throughout ; or it may stay closer to the outer wall for the most part and may be redirected to the inner wall near the distal part of the ett . a change in the plane of the secondary cannulation in the distal part of the ett ( range 1 mm - 10 mm ) will change the orientation of the secondary lumen by approximately 5 to 45 degrees . the preferable change in the angle , however , may be 10 - 15 degrees only in order to prevent tracheal or carinal impaction losses . in another modification of our invention , the secondary cannulation can run inside the primary lumen on the inner wall of the ett or it could run on the surface on the outer wall of ett . the features of the distal orifice in our invention may also have numerous variations . the distal orifice of the secondary cannulation is located at the tip of the ett , preferably not in communication with the primary lumen at the ett and not protruding beyond the distal tip of the ett . the shape of the distal orifice is preferably circular , however , the shape may be semi circular , lunar , etc . the id of the distal orifice , which may vary from 0 . 01 mm to 1 . 25 mm , may be the same or different from the id of the secondary cannulation . the id of the distal orifice may be made extremely small to generate a narrow plume or the terminal orifice may be made larger than the secondary cannulation with splaying in order to generate a wider plume . the location of the orifice may be closer to the inner wall or outer wall or it may be in the center of the ett &# 39 ; s wall . an aerosol plume which is central , and wide will result in a greater fraction of the drug loss due to impaction on the ett ( if generated proximal to the ett or in the lumen of the ett ) or the wall of the trachea ( if generated distal to the ett ) prior to reaching the distal tracheobronchial tree . an aerosol plume that is central , narrow and fast is likely to lose a greater portion of the medication by carinal impaction . an eccentrically located narrow and fast plume will avoid carinal as well as tracheal impaction losses and will ensure aerosol particle delivery to the proximal tracheobronchial tree . the distal tracheobronchial tree delivery may require an eccentric , narrow and slower plume or an eccentric wide and fast plume . in our invention the distal orifice of the secondary cannulation is located at the tip of the ett and generates aerosol at a location in the tracheobronchial tree beyond the ett , thus avoiding impaction losses . the velocity and width of the plume could be altered by adjusting the shape and id of the secondary cannulation and the distal orifice . over and above the orientation of the plume can be influenced by the trajectory of the secondary cannulation . in our invention , since the trajectory is from the outer wall towards the inner wall , preferably in the distal part of the secondary cannulation , the plume will be oriented away from the tracheal wall . the eccentric location of the orifice in the wall of the ett in our invention is preferable as it prevents carinal and tracheal impaction losses . the diameter of the ett is far smaller than that of the airway passages i . e . the trachea . on placement of the ett in the trachea and inflating the distal balloon , the wall of the distal circular edge of the ett is a few millimeters away from the tracheal wall and hence the orifice located in the wall of the distal tip of ett . depending on the size of the ett the two lateral terminal orifices os secondary cannulations may be located approximately in the center between the carina and the left or right mainstem bronchi . one may argue that the lateral location of the orifice would direct the plume preferentially to one lung . this actually may be of tremendous benefit if one wants preferential delivery of medication to one lung which has the pathology . however , if the pathological condition affects both the lungs uniformly the problem can be completely obviated by having two distal orifices diametrically opposite to each other on the lateral surface of the ett as described in the second embodiment of our invention in fig2 . it is also quite conceivable that at the time of placement of the ett and inflation of the balloon , the ett may get slightly rotated so that the two lateral orifices may not end up being in the preferred 3 o &# 39 ; clock and 9 o &# 39 ; clock positions . this problem of malaligment of the two lateral orifices with respect to the carina and the right and / or left mainstem bronchi can be overcome by the most preferable embodiment of our invention as described in fig3 . [ 0065 ] fig3 shows the longitudinal view of the ett ( 30 ) associated with an alternative embodiment of secondary cannulation . fig3 demonstrates the most preferred embodiment of our invention with six secondary cannulations in the wall of ett terminating in six distal orifices located on the circular edge of the distal tip of ett . the six orifices may preferably be equidistant from each other like the six edges of a hexagon at 1 , 3 , 5 , 7 , 9 and 11 o &# 39 ; clock positions . however , the six orifices may have several alternative symmetric or asymmetric arrangement . the six secondary cannulations and their distal orifices may be identical or completely different from each other in shape , id , trajectory , and orientation . such an arrangement would generate plumes with different characteristics i . e . geometry , velocity and orientation . in this respect a preferable arrangement would be to have three orifices on each lateral surface of ett with the ability to generate narrow and fast , narrow and slow , and wide and fast plumes from the three orifices on each side . in another arrangement , there could be eight secondary cannulations and orifices , four each on the two lateral surfaces in order to generate the wide and slow eccentric plume as well . this arrangement with total eight plumes ( ¾ plumes with different characteristics and orientation on each lateral surface ) will ensure a uniform and effective distribution of aerosol particles to proximal and distal tracheobronchial tree of both lungs . [ 0066 ] fig3 shows the longitudinal view of the ett ( 30 ), an adapter at its proximal end ( 31 ) and an inflation cuff ( 37 ). the primary cannula ( 35 ) has a flexible portion ( 33 ), the point of origin of the primary cannula ( 34 ), distal orifice ( 36 ) and proximal cuff inflation indicating an adapter for syringe ( 32 ). there are six secondary cannulations in the wall of the ett . they originate on the outer surface of the ett at the same level ( 34 ) or a level higher ( 35 ) than the primary cannula . the six cannulations continue distally in the wall of the ett to terminate as six orifices , as described before , at the distal tip of the ett . two out of six secondary carmulations ( 48 and 49 ) and a single distal orifice ( 47 ) of the secondary cannulation ( 49 ) are demonstrated in fig3 . the secondary cannulation continue proximally as six semiflexible tubules ( 45 ) outside the main tubular structure of the ett ( 30 ) without adhering to it just like the flexible part ( 33 ) of primary cannulation . the six flexible tubules are packaged in a larger hollow tube ( 43 ) that terminates distally on the outer wall of the ett . this arrangement however may be changed and there could be two larger hollow tubes packaging three flexible tubules on each side . the proximal end of the hollow tube ( 43 ) and the six tubules ( 45 ) terminate on the under surface of a circular plate ( 42 ). the six flexible tubules ( 45 ) terminate as six mdi adapters , or alternatively , the six tubules terminate as six rigid cylindrical tubules for mating with mdi adapters on the ventral surface of the circular plate ( 42 ). the circular plate ( 42 ) is attached to another circular plate through a central connector ( 40 ). the central connector ( 42 ) has a circular groove in the center and six grooves perpendicular to the circular grooves that are in alignment ( parallel ) with the six mdi adapters . the lower circular plate ( 42 ) is fixed to the central connector ( 40 ) whereas the upper circular plate ( 39 ) can rotate around the circular groove as well as move up and down along the perpendicular grooves of the central connector with the help of a handle ( 41 ). located on the peripheral rim of the ventral surface of the upper plate ( 39 ) is an mdi adapter ( 38 ). the nozzle of a pressurized canister fits into the proximal port of mdi adapter ( 38 ). the mdi adapter tapers distally to terminate on the under surface of the upper circular plate ( 39 ). the mdi adapter ( 38 ) locks into one of the rigid cylindrical tubules , the proximal end of the flexible tubules ( 45 ), located on the dorsal surface of the lower plate . the upper circular plate ( 39 ) can rotate in the circular groove , move superiorly along the perpendicular groove ( to unlock ) and move inferiorly along the perpendicular groove ( to lock ) the mdi adapter into six rigid cylindrical tubules one at a time in six different positions . hence , actuation of mdi in different positions would result in generation of six aerosol plumes at the distal orifices ( 47 ) of the secondary cannulations ( 49 ). [ 0067 ] fig4 shows an alternative embodiment of our invention to further obviate the tracheal deposition of aerosol particles as well as alter the aerosol particle size . fig4 which shows the longitudinal view of ett ( 50 ), is identical to the ett described in fig3 but with two alternative embodiments . the six flexible tubules ( 65 ), and the six secondary cannulations ( 67 ) in the wall of the ett have two coaxial lumens . the secondary cannulations terminate as two coaxial orifices ( 68 ) at the distal tip of the ett ( 50 ). the flexible cannulations ( 65 ) are packaged in a hollow tube ( 63 ), the proximal end of which terminates on the dorsal end of the lower circular plate ( 62 ) along with the flexible tubules . the distal end terminates on the outer wall of the ett ( 64 ). the point of entry or fusion with secondary cannulations ( 66 ) of the six flexible tubules ( 65 ) on the wall of the ett is demonstrated . the primary cannulations ( 54 ) with all the associated features — distal tip ( 55 ), inflatable cuff ( 56 ), flexible cannula ( 52 ), entry point ( 53 ) and cuff inflation indicator and adapter ( 51 ) are also demonstrated in fig4 . the second alternative embodiment is a modified mdi adapter ( 57 ) with an additional side port ( 58 ). the upper circular plate ( 59 ) with a handle ( 60 ) along with the central connector ( 61 ) are demonstrated . the mdi adapter has two ports . the main port ( 57 ) that has a proximal port to fit the nozzle of the pressurized canister and a distal orifice that makes an airtight connection with the inner coaxial lumen of the rigid cylindrical tubule . it also has a side port ( 58 ) that communicates with the outer coaxial lumen of the rigid cylindrical tubule . note that the rigid cylindrical tubule is the proximal end of the flexible tubule for mating with mdi adapter . the inner lumen of the main port of mdi adapter serves to generate aerosol particles by mdi canister or deliver liquid medication via a syringe at the distal tip of the ett . the side port or the outer lumen of mdi adapter may be used for vapor or gas flow for either anesthesia or to disperse the aerosolized particles generated near the distal tip of ett away from the trachea as well as to break the particle into smaller size . this device , just like the one described in fig3 incorporates the special feature of mdi adapter &# 39 ; s ability to rotate and lock in six different positions , such that through the inner coaxial lumen liquid medication or aerosol spray is conveyed and the pressurized gas is conveyed in the annular region between the inner and the outer tubular membranes . this coaxial airflow may direct the plume away from the tracheal wall and carina and hence prevent impaction losses . a variety of drug delivery rates and particle size distribution can be achieved by altering the coaxial orifice , diameters , pressure and flow characteristics of the liquid and gas in the respective orifices and by adjusting the distance between the liquid and gas flow by altering the thickness of the membrane separating the two lumens . the liquid lumen , the gas lumen and the thickness of the wall separating the two lumens may vary from 0 . 025 mm to 1 mm . in another alternative embodiment of our invention , as described in fig3 there is only one circular plate without a central connector or the upper circular plate . the six flexible tubules terminate into the single circular plate as six mdi adapters on the ventral surface of the plate . they may appear just like the mdi adapter demonstrated in fig1 . the nozzle of the mdi canister can fit into the proximal ports of mdi adapters one at a time in six different positions by manual operation . the circular plate may have a cap to cover mdi adapters when not in use . in another alternative embodiment of our invention as described in fig4 the inner coaxial lumen of the six flexible tubules may terminate on the ventral surface of the circular plate as mdi adapters and the outer coaxial lumen of the flexible tubules may terminate as six side ports on the outer surface of the circular edge of the single . in another alternative embodiment of our invention , the coaxial arrangement may be uniform and cylindrical for the most part but the inner and / or outer lumen may become semicircular in the terminal part of the ett . the flow of gas and liquid aerosol in this arrangement would direct the aerosol plume further away from the tracheal wall . in yet another alternative embodiment of our invention , the inner lumen may terminate just proximal to the distal tip of the outer semicircular lumen . [ 0072 ] fig5 a is a cross section at level ll 1 , which shows a hollow tube ( 72 ), the wall of the tube ( 71 ), the inner surface of the wall ( 73 ), and the outer surface of the wall ( 74 ). [ 0073 ] fig5 b is the same as fig5 a but with the appearance of an additional secondary cannulation ( 79 ) starting close to the outer wall ( 78 ). the main wall ( 75 ), the inner wall ( 77 ), and the lumen ( 76 ) are demonstrated . [ 0074 ] fig5 c is the cross section at the level ll 3 . this is the same as fig5 b , but there may be a change in the position of the secondary cannulation which may stay near the outer wall , move closer to the center move closer to the inner wall of the ett . there is an additional primary cannula ( 85 ) on the convex side of the ett near the outer wall for inflation and deflation of the balloon cuff . [ 0075 ] fig5 d is the same as fig5 c but with the absence of primary cannula ( 85 ) as it terminates at a higher level near the expandable balloon . the secondary cannula ( 90 ) may be closer to the inner wall ( 88 ). [ 0076 ] fig6 a is the same as fig5 a . [ 0077 ] fig6 b is the same as fig5 b but with the two secondary cannulations ( 105 and 106 ) on lateral surface of the ett diametrically opposite to each other . [ 0078 ] fig6 c is the same as fig6 b but with an additional primary cannulation ( 107 ). [ 0079 ] fig6 d is the same as fig6 c but two secondary cannulations ( 112 and 113 ) on the lateral surface near the inner wall of the ett but with loss of primary cannulation ( 107 ). [ 0080 ] fig7 a , 7 b , 7 c , and 7 d show the details of four cross sections at four levels , ll 9 - 12 of the ett as shown in fig3 . [ 0081 ] fig7 a is the same as fig6 a . [ 0082 ] fig7 b demonstrates the main lumen ( 119 ), the wall of the ett ( 118 ), the inner wall ( 120 ), the outer wall ( 121 ). there is appearance of six secondary cannulations ( 22 ) which enter the ett approximately at the same level but follow different tracts in the wall of the ett . [ 0084 ] fig7 c is the same as fig7 b but with an additional primary cannula ( 126 ). the six secondary cannulations ( 127 ) however are most separated as they follow different tracts within the wall of the ett . [ 0085 ] fig7 d is the same as fig7 c but with disappearance of primary cannula ( 128 ). the six secondary cannulations ( 123 ) now appear as the six edges of a hexagon on the distal tip close to the inner wall of the ett . the six distal orifices may not be equidistant from each other and may be have alternative arrangement along the circular edge of the tip of the ett . [ 0086 ] fig8 a , 8 b , 8 c , and 8 d show details of four cross sections at four levels ll 13 - ll 16 with an alternative embodiment as shown in fig4 . [ 0087 ] fig8 a , 8 b , 8 c , and 8 d are the same as fig7 a , 7 b , 7 c , and 7 d respectively ; the only difference that is shown here is with respect to the secondary cannulations which have two coaxial lumens as opposed to a single lumen as shown in fig7 . [ 0088 ] fig9 a , 9 b , 9 c , and 9 d represent another alternative embodiment of the four cross sections at levels ll 13 - ll 16 as demonstrated in fig4 . [ 0089 ] fig9 a , 9 b , and 9 c are identical to fig8 a , 8 b , and 8 c . [ 0090 ] fig9 d is the same as fig8 d except for a single modification . the two coaxial secondary cannulations in 9 d are different from the ones in fig8 d . fig9 d has circular inner lumen just as demonstrated in fig8 d but the outer coaxial lumen is semi - circular as opposed to circular as demonstrated in fig8 d . alternatively , in another embodiment both inner and outer lumen in 9 d could be semi - circular with the circular edges on the opposite lateral sides . [ 0091 ] fig1 shows details of a cross sectional view of the lower circular late ( 179 ), the six flexible tubules , three of which have been demonstrated by arrows ( 180 , 181 , and 182 ) that terminate on the ventral surface of the peripheral rim ( 178 ) of the circular plate ( 179 ) like the six edges of a hexagon . the central connector ( 184 ) along with the central attachment are also demonstrated here . [ 0092 ] fig1 shows the details of the cross sectional view of another embodiment of the lower circular plate that corresponds to fig4 . this is the same as fig1 , but with a single modification — the six tubules have two coaxial lumens , the inner one ( 191 ) for the liquid medication or liquid aerosol , and the outer one ( 190 ) for the gas or vapour flow . the circular plate ( 186 ), the flexible tubules ( 187 , 188 , and 189 ), the peripheral rim ( 185 ) of circular plate , the central connector ( 193 ), and the central attachment of the plate to the rod ( 192 ) are demonstrated . [ 0093 ] fig1 is a perspective view of the lower circular plate ( 195 ) shown in fig1 . the flexible tubule ( 196 ) terminates ( 195 ) as rigid cylindrical tubule on the ventral surface of the peripheral rim ( 194 ) of the circular plate ( 195 ). other flexible tubules ( 196 and 197 ) are demonstrated as well . [ 0094 ] fig1 is a perspective view of the lower circular plate ( 200 ) shown in fig1 . the two coaxial tubules — inner ( 205 ) and outer ( 204 ) terminate on the ventral surface ( 203 ) of the circular plate . [ 0095 ] fig1 shows mdi adapter ( 208 ) as shown in fig1 and 2 . the mdi adapter is located in the center at the circular plate ( 209 ) with peripheral handles ( 210 and 211 ). the mdi adapter tapers distally to continue as a single flexible tubule ( 212 ) that continues as secondary cannulation ( not shown ) in the wall of the ett . [ 0096 ] fig1 shows the upper plate with mdi adapter ( 211 ) as shown in fig3 . a single mdi adapter ( 211 ) on the peripheral rim ( 212 ) of the circular plate is demonstrated here . the circular plate rotates around a central connector ( 215 ) in the central groove ( 213 ). to facilitate the rotation , the central plate has a handle ( 214 ). [ 0097 ] fig1 shows upper plate ( 220 ) with mdi adapter ( 217 ) with a handle ( 221 ), a central connector and attachment ( 222 ) as shown in fig4 . a single mdi adapter ( 217 ) with a side port ( 218 ) is attached to the circular plate ( 220 ) at its peripheral rim ( 219 ). [ 0098 ] fig1 shows the top cross sectional view of mdi adapter shown in fig1 , 15 , and 16 . the mdi adapter has an inlet port ( 226 ) and two concentric rings ( 225 and 226 ) with decreasing circumferencial perimeter such that the mdi nozzle locks into the innermost concentric ring ( 226 ). the terminal orifice ( 227 ) marks the point of fusion or mating with the proximal end of the flexible tubule . the structure of the internal lumen of mdi adapter could be modified in numerous ways to fit the nozzle of the mdi . [ 0099 ] fig1 shows the bottom cross sectional view of the mdi adapter shown in fig1 and 15 . the mdi adapter &# 39 ; s innermost ring ( 229 ) to fit the nozzle of mdi and the distal orifice ( 228 ) through which the aerosol particles are generated are demonstrated in this figure . [ 0100 ] fig1 shows the bottom cross sectional view of the mdi adapter shown in fig1 . it is the same as fig1 except for one extra outer ring ( 230 ). the shaded area ( 233 ) between the two rings ( 230 and 232 ) is a tubular hollow space that communicates with a side port ( 218 ) shown in fig1 . this hollow space is the coaxial outer lumen . [ 0101 ] fig2 shows the upper and the lower plates together as shown in fig3 and 15 . [ 0102 ] fig2 shows the upper and the lower plates together as shown in fig4 and 16 . [ 0103 ] fig2 demonstrates an alternative embodiment of fig2 with the upper and lower plates aligned together . as opposed to the mdi adapter ( 258 ) having a side port for the gas flow , the side port could be a part of the assembly of the lower plate ( 267 ). the central flexible tubule ( 266 ) terminates proximally on the ventral surface ( 265 ) of the lower plate ( 264 ). the side port ( 267 ) terminates proximally ( 268 ) on the dorsal surface of the lower plate . distally the side port continues as the outer coaxial flexible tubule ( 269 ). the mdi adapter ( 258 ) of the upper plate ( 259 ) locks into the proximal orifice ( 265 ) of the flexible tubule . the mdi adapter can lock in six different positions one at a time with each of the flexible tubules as described earlier . the side port ( 267 ) serves the purpose of gas or vapor flow to the outer coaxial lumen . [ 0104 ] fig2 shows the cross sectional view of the ett as shown in fig7 d along with two dimensional geometry and direction of the plume generated from each of the orifices of secondary cannulations at the distal tip of the ett . the terminal orifice generates a plume that moves distally along the inner circular edge of the ett ( arrows 274 and 277 ) as well as away from the inner edge ( arrow 276 ). the area under the curve of the aerosol plume generated from any one orifice maybe approximately ⅓ to ½ of the area formed by the primary lumen at the endotracheal tube . the six aerosol plumes generated from six distal orifices ensure uniform distribution of medication in the tracheobroncial tree of both lungs as demonstrated . [ 0105 ] fig2 is the same as fig8 d with the direction of the plumes as shown in fig2 . the airflow in the outer coaxial tube will prevent the tracheal and carnal impaction of aerosol particles . [ 0106 ] fig2 is the same as fig9 d with the direction of the plume being further away from the tracheal wall ( 293 ). in this figure the airflow from the semi - circular outer coaxial tube ( 295 ) will redirect the liquid aerosol from the inner lumen ( 294 ) away from the tracheal wall . it is noted that the illustration ( drawings ) and description of the preferred embodiments have been provided merely for the purpose of explanation and although the invention has been described herein with reference to particular means , materials and embodiments , the invention is not intended to be limited to the particulars disclosed herein ; rather the invention intends to all functionally equivalent structures , methods and uses such as are within the scope of the appended claims .
current methods of drug administration to the lungs are inefficient . ‘ endotracheal tube with aerosol delivery apparatus ii ’ is specifically designed for uniform intrapulmonary delivery of aerosolized medication in patients on mechanical ventilation . as opposed to the current methods of drug delivery where aerosol particles are generated at the proximal end of the ett , with majority of the particles adhering to the endotracheal tube during delivery , this invention bypasses the endotracheal tube by generating aerosol particles at its distal end . this invention incorporates 1 to 6 secondary cannulations in the wall of the ett with pinhole terminal orifices at the distal tip of the ett arranged symmetrically . the secondary cannulations continue proximally as semi - flexible tubules that terminate as mdi adapters to fit the nozzle of mdi canister . this device generates 1 - 6 aerosol plumes . numerous variations in the id , shape , trajectory and location of the secondary cannulations and distal orifices in the wall of the ett generate aerosol plumes with velocity , geometry , particle size and orientation that ensures effective aerosol delivery to the respiratory system .