i . nanomaterial with thermal conductivity ii . nanomaterial with porosity / permeability iii . nanomaterial with enhanced luminescence iv . nanomaterial with enhanced acoustics v . nanomaterial with magnetic properties vi . nanomaterial with enhanced solubility vii . shape engineered nanomaterials viii . nanomaterials with enhanced optical properties unless otherwise defined , all terms of art , notations and other scientific terms or terminology used herein are intended to have the meanings commonly understood by those of skill in the art to which this invention pertains unless the context clearly indicates otherwise . in some cases , terms with commonly understood meanings are defined herein for clarity and / or for ready reference , and the inclusion of such definitions herein should not necessarily be construed to represent a substantial difference over what is generally understood in the art . many of the techniques and procedures described or referenced herein are well understood and commonly employed using conventional methodology by those skilled in the art . as used herein the terms “ drug ” and “ pharmaceutical ” include veterinary drugs and human drugs , including human biological drug products . “ nanomaterial ” means a material in any dimensional form ( zero , one , two , three ) and domain size less than 100 nanometers . “ nanostructure ” means a structure having at least one dimension that is less than 500 nanometers . examples , include but are not limited to nanocrystals , nanocomposites , nanograins , nanotubes , nanoceramics , and nanopowders . “ nanocrystal ” means nanostructures that are substantially monocrystalline . a nanocrystal has at least one region or characteristic dimension with a dimension of less than about 500 nm , and down to on the order of less than about 1 nm . as used herein , when referring to any numerical value , “ about ” means a value of .+−. 10 % of the stated value ( e . g . about 100 nm encompasses a range of sizes from 90 nm to 110 nm , inclusive ). the terms “ nanocrystal ,” “ nanodot ,” “ dot ” and “ quantum dot ” are readily understood by the ordinarily skilled artisan to represent like structures and are used herein interchangeably . the present invention also encompasses the use of polycrystalline or amorphous nanocrystals . “ aspect ratio ” means the ratio of the maximum to the minimum dimension of a particle . “ biomaterial ” ( a . k . a . biological material ) may refer to biological matter , biomass , biomolecule , and organic material ( i . e . derived from living things or containing carbon ). “ integrated circuits ( ic )” means a miniaturized electronic circuit that has been manufactured in the surface of a thin substrate of semiconductor material . “ hybrid integrated circuit ” means a miniaturized electronic circuit bonded to a substrate or circuit board . “ nanowire ” means a wire of dimensions of the order of a nanometer ( 10 − 9 meters ). alternatively , nanowires can be defined as structures that have a lateral size constrained to tens of nanometers or less and an unconstrained longitudinal size . nanowires include metallic ( e . g ., ni , pt , au ), semiconducting ( e . g ., inp , si , gan , etc . ), and insulating ( e . g ., sio 2 , tio 2 ). molecular nanowires are composed of repeating molecular units either organic ( e . g . dna ) or inorganic ( e . g . mo 6 s 9 - x i x ). “ domain size ” means the minimum dimension of a particular material morphology . in the case of powders , the domain size is the grain size . in the case of whiskers and fibers , the domain size is the diameter . in the case of plates and films , the domain size is the thickness . “ nanopowder ” ( a . k . a . “ nanosize powders ,” “ nanoparticles ,” and “ nanoscale powders ”) means and refer to fine powders that have a mean size less than 250 nanometers . for example , in some embodiments , the nanopowders are powders that have particles with a mean domain size less than 100 nanometers and with an aspect ratio ranging from 1 to 1 , 000 , 000 . pure powders , as the term used herein , are powders that have composition purity of at least 99 . 9 % by metal basis . for example , in some embodiments the preferred purity is 99 . 99 %. “ powder ” ( a . k . a . “ powder ”, “ particle ”, and “ grain ”) are used interchangeably and encompass oxides , carbides , nitrides , borides , chalcogenides , halides , metals , intermetallics , ceramics , polymers , alloys , and combinations thereof . these terms include single metal , multi - metal , and complex compositions . these terms further include hollow , dense , porous , semi - porous , coated , uncoated , layered , laminated , simple , complex , dendritic , inorganic , organic , elemental , non - elemental , composite , doped , undoped , spherical , non - spherical , surface functionalized , surface non - functionalized , stoichiometric , and non - stoichiometric forms or substances . further , the term powder in its generic sense includes one - dimensional materials ( fibers , tubes ; etc . ), two - dimensional materials ( platelets , films , laminates , planar , etc . ), and three - dimensional materials ( spheres , cones , ovals , cylindrical , cubes , monoclinic , parallelolipids , dumbbells , hexagonal , truncated dodecahedron , irregular shaped structures , etc .). the term metal used above includes any alkali metal , alkaline earth metal , rare earth metal , transition metal , semi - metal ( metalloids ), precious metal , heavy metal , radioactive metal , isotopes , amphoteric element , electropositive element , cation - forming element , and includes any current or future discovered element in the periodic table . “ precursor ” means any raw substance that can be transformed into a powder of same or different composition . in certain embodiments , the precursor is a liquid . the term precursor includes , but is not limited to , organometallics , organics , inorganics , solutions , dispersions , melts , sols , gels , emulsions , or mixtures . “ nanofiller ” ( a . k . a . nanostructured filler ) means a structure or particle intimately mixed with a matrix to form a nanostructured composite . at least one of the nanostructured filler and the nanostructured composite has a desired material property which differs by at least 20 % from the same material property for a micron - scale filler or a micron - scale composite , respectively . the desired material property is selected from the group consisting of refractive index , transparency to light , reflection characteristics , resistivity , permittivity , permeability , coercivity , b — h product , magnetic hysteresis , breakdown voltage , skin depth , curie temperature , dissipation factor , work function , band gap , electromagnetic shielding effectiveness , radiation hardness , chemical reactivity , thermal conductivity , temperature coefficient of an electrical property , voltage coefficient of an electrical property , thermal shock resistance , biocompatibility and wear rate . the nanostructured filler may comprise one or more elements selected from the s , p , d , and f groups of the periodic table , or it may comprise a compound of one or more such elements with one or more suitable anions , such as aluminum , antimony , boron , bromine , carbon , chlorine , fluorine , germanium , hydrogen , indium , iodine , nickel , nitrogen , oxygen , phosphorus , selenium , silicon , sulfur , or tellurium . the matrix may be a polymer ( e . g ., poly ( methyl methacrylate ), poly ( vinyl alcohol ), polycarbonate , polyalkene , or polyaryl ), a ceramic ( e . g ., zinc oxide , indium - tin oxide , hafnium carbide , or ferrite ), or a metal ( e . g ., copper , tin , zinc , or iron ). loadings of the nanofiller may be as high as 95 %, although loadings of 80 % or less are preferred . the invention also comprises devices which incorporate the nanofiller ( e . g ., electrical , magnetic , optical , biomedical , and electrochemical devices ). “ coating ” ( a . k . a . “ film ”, “ laminate ”, or “ layer ”) means any deposition comprising submicron and nanoscale powders . the term includes in its scope a substrate , surface , deposition , or a combination thereof having a hollow , dense , porous , semi - porous , coated , uncoated , simple , complex , dendritic , inorganic , organic , composite , doped , undoped , uniform , non - uniform , surface functionalized , surface non - functionalized , thin , thick , pretreated , post - treated , stoichiometric , or non - stoichiometric form or morphology . “ agglomerated ” means a powder in which at least some individual particles of the powder adhere to neighboring particles , primarily by electrostatic forces . “ aggregated ” means a powder in which at least some individual particles are chemically bonded to neighboring particles . “ supramolecular electronics ” means the assemblies of pi - conjugated systems on the 5 to 100 nanometer length scale that are prepared by self - assembly with the aim to fit these structures between electrodes . “ biosensor ” means a device for the detection of an analyte that combines a biological component with a physicochemical detector component . a biosensor comprises three parts : ( i ) a sensitive biological element ( i . e . biological material , including but not limited to , tissue , microorganisms , organelles , cell receptors , enzymes , antibodies , nucleic acids , amino acids , etc ) or a biologically derived material or biomimic ; ( ii ) a transducer ; ( iii ) a detector element ( i . e . chemical , physiochemical , optical , piezoelectric , electrochemical ; thermometric , or magnetic ). “ optical biosensor ” means a biosensor that utilizes the behavior and properties of light and the interaction of light with matter as the detector element . “ optical switch ” means a switch that enables signals in optical fibers or integrated optical circuits ( iocs ) to be selectively switched from one circuit to another . “ pi - conjugated systems ” ( a . k . a . “ stacking ”) means the noncovalent interaction between organic compounds containing aromatic moieties . π - π interactions are caused by intermolecular overlapping of p - orbitals in π - conjugated systems , so they become stronger as the number of π - electrons increases . “ quantum dots ” means a semiconductor nanostructure that confines the motion of conduction band electrons , valence band holes , or excitons ( pairs of conduction band electrons and valence band holes ) in all three spatial directions . the confinement can be due to electrostatic potentials ( generated by external electrodes , doping , strain , impurities ), due to the presence of an interface between different semiconductor materials ( e . g . in the case of self - assembled quantum dots ), due to the presence of the semiconductor surface ( e . g . in the case of a semiconductor nanocrystal ), or due to a combination of these . a quantum dot has a discrete quantized energy spectrum . “ molecular self - assembly ” means the assembly of molecules without guidance or management from an outside source . “ nanocomposite ” means materials that are created by introducing nanoparticulates into a macroscopic sample material . the nanomaterials add to the electrical and thermal conductivity as well as to the mechanical strength properties of the original material . in general , the nanomaterial used are carbon nanotubes and they are dispersed into the other composite materials during processing . the percentage by weight of the nanomaterials introduced is able to remain very low ( on the order of 0 . 5 %- 5 %) due to the incredibly high surface area to volume ratio of the particles . “ molecular electronics ” ( a . k . a . moletronics ) means an interdisciplinary themed materials science in which the unifying feature is the use of molecular building blocks for the fabrication of electronic components , both passive ( e . g . resistive wires ) and active ( e . g transistors ). molecular electronics provides a means to extend moore &# 39 ; s law beyond the foreseen limits of small - scale conventional silicon integrated circuits . “ moore &# 39 ; s law ” means the empirical observation made in 1965 that the number of transistors on an integrated circuit for minimum component cost doubles every 24 months . it is attributed to gordon e . moore ( born 1929 ), a co - founder of intel . “ supramolecular chemistry ” means the area of chemistry which focuses on the noncovalent bonding interactions of molecules . traditional organic synthesis involves the making and breaking of covalent bonds to construct a desired molecule . “ molecular recognition ” means a chemical event in which a host molecule is able to form a complex with a second molecule ( i . e . the guest ). this process occurs through non - covalent chemical bonds , including but not limited to , hydrogen bonding , hydrophobic interactions , ionic interaction . “ static molecular recognition ” means a 1 : 1 type complexation reaction between a host molecule and a guest molecule ( an analogy is the interaction between a key and a keyhole .) to achieve advanced static molecular recognition , it is necessary to make recognition sites that are specific for guest molecules . “ dynamic molecular recognition ” means a reaction that dynamically changes the equilibrium to an n : m type host - guest complex by a recognition guest molecule . dynamic molecular recognition appearing in supermolecules is essential for designing highly functional chemical sensors and molecular devices . “ rotaxane ” means a mechanically - interlocked molecular architecture consisting of a dumbbell - shaped molecule that is threaded through a macrocycle or ring - like molecule . the two components are kinetically trapped as the two end - groups of the dumbbell ( often called stoppers ) are larger than the internal diameter of the ring , and thus prevent dissociation ( unthreading ) since this would require significant distortion of the covalent bonds . the name , rotaxane , is derived from the latin for wheel ( rota ) and axle ( axis ). “ synthetic molecular motors ” means nanoscale devices capable of rotation under energy input . the basic requirements for a synthetic motor are repetitive 360 ° motion , the consumption of energy , and unidirectional rotation . examples include but are not limited to triptycence motors and helicene . “ bar code ” means a code representing characters by sets of parallel bars of varying thickness and separation that are read optically by transverse scanning . “ calibration ” means ensuring continuous adequate performance of sensing , measurement , and actuating equipment with regard to specified accuracy and precision requirements . “ certification ” means technical evaluation , made as part of and in support of the accreditation process that establishes the extent to which a particular computer system or network design and implementation meet a pre - specified set of requirements . “ validation ” means establishing documented evidence which provides a high degree of assurance that a specific process will consistently produce a product meeting its predetermined specifications and quality attributes . “ batch ” means a specific quantity of a drug or other material that is intended to have uniform character and quality , within specified limits , and is produced according to a single manufacturing order during the same cycle of manufacture . “ component ” means any ingredient intended for use in the manufacture of a drug product , including those that may not appear in such drug product . “ drug product ” means a final formulation that contains an active drug ingredient generally , but not necessarily , in association with inactive ingredients . the term also includes a finished dosage form that does not contain an active ingredient but is intended to be used as a placebo . “ active ingredient ” means any component that is intended to furnish pharmacological activity or other direct effect in the diagnosis , cure , mitigation , treatment , or prevention of disease , or to affect the structure or any function of the body of man or other animals . the term includes those components that may undergo chemical change in the manufacture of the drug product and be present in the drug product in a modified form intended to furnish the specified activity or effect . “ in - process material ” means any material fabricated , compounded , blended , or derived by chemical reaction that is produced for , and used in , the preparation of the drug product . “ lot number , control number , or batch number ” means any distinctive combination of letters , numbers , or symbols , or any combination thereof , from which the complete history of the manufacture , processing , packing , holding , and distribution of a batch or lot of drug product or other material can be determined . “ quality control unit ” means any person or organizational element designated by the firm to be responsible for the duties relating to quality control . “ acceptance criteria ” means the product specifications and acceptance / rejection criteria , such as acceptable quality level and unacceptable quality level , with an associated sampling plan , that are necessary for making a decision to accept or reject a lot or batch . “ process analytical technology ” ( a . k . a . pat ) means a mechanism to design , analyze , and control pharmaceutical manufacturing processes through the measurement of critical process parameters and quality attributes . “ new molecular entity ” ( a . k . a . nme or new chemical entity (“ cne ”)) means a drug that contains no active moiety that has been approved by fda . an active moiety means the molecule or ion , excluding those appended portions of the molecule that cause the drug to be an ester , salt ( including a salt with hydrogen or coordination bonds ), or other noncovalent derivative ( such as a complex , chelate , or clathrate ) of the molecule , responsible for the physiological or pharmacological action of the drug substance . “ ph ” means is a measure of the activity of hydrogen ions ( h + ) in a solution and , therefore , its acidity . “ encapsulation ” means a range of techniques used to enclose medicines in a relatively stable shell , allowing them to , for example , be taken orally or be used as suppositories . the two main types of capsules are hard - shelled capsules , which are normally used for dry , powdered ingredients , and soft - shelled capsules , primarily used for oils and for active ingredients that are dissolved or suspended in oil . both of these classes of capsule are made both from gelatine and from plant - based gelling substances like carrageenans and modified forms of starch and cellulose . “ route of administration ” means the path by which a drug product , fluid , poison , or other substance is brought into contact with the body . “ pharmaceutical formulation ” means the process in which different chemical substances are combined to a pure drug substance to produce a final drug product . “ dosage form ” means the physical form of a dose of a drug product , such as a capsule or injection . the route of administration is dependent on the dosage form of a given drug . examples of dosage forms of the invention are set forth in table i . “ excipient ” means an inactive substance used as a carrier for the active ingredients in a drug such as vaccines . excipients are also sometimes used to bulk up formulations with very potent active ingredients , to allow for convenient and accurate dosage . examples of excipients , include but are not limited to , antiadherents , binders , coatings , disintegrants , fillers , dilutents , flavors , colors , lubricants , and preservatives . “ vehicle ” means the excipients or matrix in which the active ingredient is prepared ( e . g ., normal saline ). “ potency ” means substantively , the strength of a drug ( i . e . vaccine ) but more complex . it is not a factor proportional to the concentration of the active ingredient ( antigen ) but rather to the immunogenicity of the drug product ( formulated antigen ). so , just saying there is 300 mg of gp120 or 1 mg of dna there in the vial isn &# 39 ; t sufficient , the question is “ is it immunogenic ”? for a background on potency testing of vaccines , see , habig , veterinary microbiology , 37 : 343 - 51 : 1993 . it concludes that a potency test should be reasonably predicative of efficacy in humans , i . e ., measure a parameter that correlates with efficacy . another important aspect to remember is that it should be sufficiently quantitative , so that it can be determined if your vaccine has lost 30 %, 50 %, or 70 % potency , for example . “ bulk ” ( a . k . a . drug substance ) means the drug substance or the drug product which has not been filled into final containers for distribution . final formulated bulk generally refers to drug product which is formulated and being stored or held prior to filling . drug substance may be stored or held as “ bulk ” or “ concentrated bulk ” prior to formulation into drug product . the present invention provides for nanomaterials which are manufactured to achieve a desired function or property that will assist in the packaging of drug products . nanomaterials of the inventions comprise nanostructures , nanocrystals , nanowires , nanotubes , nanofillers , nanocomposites , and precursors or any combination thereof . the nanomaterials useful in the present invention can also further comprise ligands conjugated , cooperated , associated or attached to their surface as described throughout . suitable ligands include any group known to those skilled in the art . use of such ligands can enhance the ability of the nanocrystals to incorporate into various solvents and matrixes , including polymers . increasing the miscibility ( i . e ., the ability to be mixed without separation ) of the nanocrystals in various solvents and matrixes allows them to be distributed throughout a polymeric composition such that the nanocrystals do not aggregate together and therefore do not scatter light . such ligands are described as “ miscibility - enhancing ” ligands herein . in a further embodiment , the invention provides polymeric layers comprising a polymer and nanocrystals embedded within the polymer , such that the layers act as photon - filtering nanocomposites . suitably , the nanocrystals will be prepared from semiconductor materials , but any suitable material described throughout can be used to prepare the nanocrystals . in certain embodiments , the nanocrystals will have a size and a composition such that the nanocrystals absorb light of a particular wavelength or over a range of wavelengths . as such , the nanocrystals utilized in these embodiments are tailored such that their absorption characteristics are enhanced or maximized , while their emission characteristics are minimized , i . e . they will absorb light in a highly efficient manner , but suitably will emit only a very low level , or preferably no light . in other embodiments , however , the photon - filtering nanocomposites can also comprise nanocrystals that have high emission properties and emit light at a particular wavelength as discussed throughout . as such , the present invention provides nanocomposites that comprise different types of nanocrystals such that the nanocomposites exhibit several , or all , of the properties discussed throughout , in a layer . in embodiments of the present invention where the photon - filtering polymeric layers are used to coat pharmaceutical dosage forms , such dosage forms can be refractive ( e . g ., lenses ) or reflective ( e . g ., mirrors ). additionally , in certain embodiments of the present invention where the photon - filtering polymeric layers are used to encapsulate drug products , such drug products can be enclosed in any dosage form known to the skilled artisan . by controlling the size and composition of the nanocrystals used in the practice of the present invention , the nanocrystals will absorb light of a particular wavelength , or a particular range of wavelengths , while not scattering light . the ability to make nanocrystals out of different semiconductors , and control their size , allows for pharmaceutical dosage forms to be fabricated with nanocrystals that will absorb light from the uv , to visible , to near infrared ( nir ), to infrared ( ir ) wavelengths . nanocrystals for use in the present invention will suitably be less than about 100 nm in size , and down to less than about 2 nm in size . in suitable embodiments , the nanocrystals of the present invention absorb visible light . as used herein , visible light is electromagnetic radiation with wavelengths between about 380 and about 780 nanometers that is visible to the human eye . visible light can be separated into the various colors of the spectrum , such as red , orange , yellow , green , blue , indigo and violet . the photon - filtering nanocomposites of the present invention can be constructed to absorb light that makes up any one or more of these colors . for example , the nanocomposites of the present invention can be constructed to absorb blue light , red light , or green light , combinations of such colors , or any colors in between . as used herein , blue light comprises light between about 435 nm and about 500 nm , green light comprises light between about 520 nm and 565 nm and red light comprises light between about 625 nm and about 740 nm in wavelength . one of ordinary skill will be able to construct nanocomposites that can filter any combination of these wavelengths , or wavelengths between these colors , and such nanocomposites are embodied by the present invention . as disclosed herein , the nanocrystals useful in the practice of the present invention can have a composition and a size such that they absorb light at a particular wavelength ( s ) and emit at a particular wavelength ( s ). in certain embodiments , the dosage forms of the present invention can comprise combinations of nanocrystals that function in the various ways described herein . for example , a nanocomposite of the present invention can comprise nanocrystals having specific , enhanced emission properties , others having specific , enhanced absorption properties but low emission properties , and the entire nanocomposite can be constructed such that the layer has a specific refractive index that is matched or tailored for a specific purpose . combined in such a way , the pharmaceutical dosage forms of the present invention can be used as encapsulates for drug products ( e . g . biologics , vaccines and injectables , blood products , diagnostic products , antibiotics , anti - inflammatory medicines etc .). in preferred embodiments , it is desirable that the nanocrystals do not aggregate . that is , that they remain separate from each other in the dosage form and do not coalesce with one another to form larger aggregates . this is important , as individual crystals will not scatter light passing through the layer , while larger aggregated structures can create an opaque layer that can hinder the passage of light . however , depending on the parameters and individual specifications of the dosage form in which the nanomaterials are used the degree of aggregation may need to be modified to achieve the desired result . dispersion of nanocrystals into the drug product can be controlled by minimizing phase separation and aggregation that can occur when interfacing ( physical ) the nanocrystals with the drug product . a basic strategy known in the art is to design a 3 - part ligand , in which the head - group , tail - group and middle / body - group can each be independently fabricated and optimized for their particular function , and then combined into an ideally functioning complete surface ligand . in on embodiment , the head group is selected to bind specifically to the material of the nanocrystal ( or nanocrystal dosage form as the case may be ). in one embodiment , the tail group is designed to interact strongly with the drug product and be miscible in the solvent utilized ( and can , optionally , contain a linker group to the drug product ) to allow maximum miscibility and loading density in the drug product without nanocrystal aggregation . in one embodiment , the middle or body group is selected for specific electronic functionality ( e . g ., charge isolation , input / output , detector , etc ). in another aspect of the invention nanomaterials comprise nanowires . while the example implementations described herein principally use si , other types of nanowires ( and other nanostructures such as nanoribbons , nanotubes , nanorods and the like ) can be used including semiconductive nanowires , that are comprised of semiconductor material selected from , e . g ., si , ge , sn , se , te , b , c ( including diamond ), p , b — c , b — p ( bp6 ), b — si , si — c , si — ge , si — sn and ge — sn , sic , bn / bp / bas , aln / alp / alas / alsb , gan / gap / gaas / gasb , inn / inp / inas / insb , bn / bp / bas , aln / alp / alas / alsb , gan / gap / gaas / gasb , inn / inp / inas / insb , zno / zns / znse / znte , cds / cdse / cdte , hgs / hgse / hgte , bes / bese / bete / mgs / mgse , ges , gese , gete , sns , snse , snte , pbo , pbs , pbse , pbte , cuf , cucl , cubr , cui , agf , agcl , agbr , agi , besin2 , cacn2 , zngep2 , cdsnas2 , znsnsb2 , cugep3 , cusi2p3 , ( cu , ag )( al , ga , in , tl , fe )( s , se , te ) 2 , si3n4 , ge3n4 , al . sub . 2o . sub . 3 , ( al , ga , in ) 2 ( s , se , te ) 3 , al2co , and an appropriate combination of two or more such semiconductors . additionally , the nanowires of the invention can include carbon nanotubes , or conductive or semiconductive organic polymer materials , ( e . g ., pentacene , and transition metal oxides ). in another aspect of the invention , nanomaterials of the invention comprise nanotubes . nanotubes can be formed in combinations / thin films of nanotubes as is described herein for nanowires , alone or in combination with nanowires , to provide the properties and advantages described herein . in one aspect of the invention nanomaterials are fabricated to create a pharmaceutical dosage form ( table i ). one of ordinary skill in the art will appreciate that the entire dosage form may comprise nanomaterials or the dosage form will consist of nanomaterials to achieve the desired functions described herein . in one embodiment , the nanomaterial is designed to include a functional property . the preferred functional property is one that provides a synergy with the dosage form and the drug product that the nanomaterial is being utilized in concert with . for example , nanomaterials may possess optical properties useful in detection of particulates or contaminates in gas or aerosols . this is particularly useful in monitoring the quality of inhalants that have been in storage for some time . in another example , a nanomaterial may possess thermal properties whereby deviations in temperature may be detected . this is particularly useful for drug products that are dependent on temperature for viability ( i . e . vaccines , blood products ). a very wide variety of pure phase materials such as polymers are now readily known in the art . however , low cost pure phase materials are somewhat limited in the achievable ranges of a number of properties , including , for example , electrical conductivity , magnetic permeability , dielectric constant , and thermal conductivity . in order to circumvent these limitations , it has become common to form composites , in which a matrix is blended with a filler material with desirable properties . in one embodiment , the invention comprises a nanofiller , intimately mixed with a matrix to form a nanostructured composite . at least one of the nanostructured filler and the nanostructured composite has a desired material property which differs by at least 20 % from the same material property for a micron - scale filler or a micron - scale composite , respectively . the desired material property is selected from the group consisting of refractive index , transparency to light , reflection characteristics , resistivity , permittivity , permeability , coercivity , b — h product , magnetic hysteresis , breakdown voltage , skin depth , curie temperature , dissipation factor , work function , band gap , electromagnetic shielding effectiveness , radiation hardness , chemical reactivity , thermal conductivity , temperature coefficient of an electrical property , voltage coefficient of an electrical property , thermal shock resistance , biocompatibility and wear rate . the nanofiller may comprise one or more elements selected from the s , p , d , and f groups of the periodic table , or it may comprise a compound of one or more such elements with one or more suitable anions , such as aluminum , antimony , boron , bromine , carbon , chlorine , fluorine , germanium , hydrogen , indium , iodine , nickel , nitrogen , oxygen , phosphorus , selenium , silicon , sulfur , or tellurium . the matrix may be a polymer ( e . g ., poly ( methyl methacrylate ), poly ( vinyl alcohol ), polycarbonate , polyalkene , or polyaryl ), a ceramic ( e . g ., zinc oxide , indium - tin oxide , hafnium carbide , or ferrite ), or a metal ( e . g ., copper , tin , zinc , or iron ). loadings of the nanofiller may be as high as 95 %, although loadings of 80 % or less are preferred . the invention also comprises devices which incorporate the nanofiller ( e . g ., electrical , magnetic , optical , biomedical , and electrochemical devices ). in one aspect of the invention , the nanomaterial possesses the functional property of thermal conductivity . any nanoparticle that can be functionalized and which has a higher thermal conductivity than the organic matrix can be used to prepare the present compositions . suitable nanoparticles include but are not limited to colloidal silica , polyhedral oligomeric silsesquioxane (“ poss ”), nano - sized metal oxides ( e . g . alumina , titania , zirconia ), nano - sized metal nitrides ( e . g . boron nitrides , aluminum nitrides ) and nano - metal particles ( e . g ., silver , gold , or copper nanoparticles ). in particularly useful embodiments , the nanoparticles are organo - functionalized poss materials or colloidal silica . colloidal silica exists as a dispersion of submicron - sized silica ( sio 2 ) particles in an aqueous or other solvent medium . the colloidal silica contains up to about 85 weight % of silicon dioxide ( sio 2 ) and typically up to about 80 weight % of silicon dioxide . the particle size of the colloidal silica is typically in a range between about 1 nanometers (“ nm ”) and about 250 nm , and more typically in a range between about 5 nm and about 150 nm . the fillers used are micron - sized thermally conductive materials and can be reinforcing or non - reinforcing . in one embodiment , the present nanomaterial with thermal functionality can be formed into sheets and cut into any desired shape . in a preferred embodiment , the nanomaterials can advantageously be used for thermal interface pads and positioned on thermal biosensors . in a further embodiment , the thermal interface pad and thermal biosensor is fabricated into a pharmaceutical dosage form to monitor temperature of the drug product enclosed therein . in one embodiment , nanomaterials posses predefined porosity and permeability properties . the properties are useful in the design of filters that are fabricated into pharmaceutical dosage forms . the filers can be used for such process as purification , etc . the nanomaterials are designed with a membrane or layer that is designed to block certain objects or substances while letting others through . the porosity / permeability properties of the nanomaterials can be used to separate liquids from liquids , solids from liquids , gas from liquids , or any combination of thereof . in a preferred embodiment , the porosity / permeability properties are designed to be advantageous to monitor the quality ( such as purity , potency , etc ) of the drug product enclosed within the dosage form . in one embodiment , nanomaterials posses enhanced luminescent properties . the nanomaterials are made from nanopowders using standard methods known in the art . for example , luminescent nanomaterial is prepared using the following steps : forming a homogenized precursor solution of at least one lanthanide group metal precursor and at least one lanthanide series dopant precursor ; adding a phosphate source and a fuel to the precursor solution ; removing water from the precursor solution to leave a reaction concentrate ; and igniting the reaction concentrate to form a powder comprising the plurality of nanoparticles . the nanomaterials of the invention can be used in pharmaceutical dosage form applications such as , display devices and imaging applications positioned on the pharmaceutical dosage form itself . in a preferred embodiment , the nanomaterials will be used in the quality monitoring of pharmaceutical dosage forms . in a further embodiment , the nanomaterial will display a pre - determined schema when the quality of the pharmaceutical dosage form is outside the scope of the quality parameters set forth by the quality control protocol . it will be readily apparent to one of skill in the art that the schema can comprise a wide array of displays , including but not limited to , changing colors ( including but not limited to red , blue , and green ), displaying a symbol ( e . g . and “ x ”), displaying a word ( e . g . “ expired ”). in one embodiment , nanomaterials posses enhanced acoustic functions . the nanomaterials are made from using standard methods known in the art . for example , a surface acoustic wave device fabricated on a lithium niobate substrate and a sensing bilayer positioned on the acoustic path of the surface acoustic wave device , the sensing bilayer further comprising nanocrystalline or other nanomaterial such as nanoparticles or nanowires of palladium and metal free phthalocyanine . preferably , the surface acoustic wave device has a center frequency of about 200 mhz . nanomaterials with enhanced acoustic properties will respond to gases ( i . e . hydrogen , helium , etc .) in near real time , at low ( room ) temperature , without being affected by co 2 , ch 4 and other gases , in air ambient or controlled ambient , providing sensitivity to low ppm levels . in a preferred embodiment , the nanomaterials detect and monitor gases enclosed in pharmaceutical dosage forms described herein . in a further embodiment , the nanomaterial displays a pre - determined schema when the quality of the pharmaceutical dosage form is outside the scope of the quality parameters set forth by the quality control protocol . in one embodiment , nanomaterials posses enhanced magnetic functions . the nanomaterials are made from using standards known in the art . for example , a solvent , preferably an ether or an aromatic solvent such as toluene , anisole , dioctylether , or the like , is added to a carboxylic acid , preferably oleic acid , or the like . an amine , preferably oleylamine or the like is then added to the solvent and oleic acid solution to complete solution a . it will be appreciated that other solvents or amines not listed here may be used to perform the same decomposition . the solution a is added to a metal - organic precursor to form solution b . solution b is then heated , for example by radiation at approximately 150 degrees c . in anisole for approximately 48 hours , under pressure , for example 3 bars of h2 . nanorods begin to appear . the nanorods are crystalline hexagonal close packed ( hcp ), and grow along the c axis of the structure . the nanorods are in a thermodynamically stable form of cobalt after completion of the reaction . these thermodynamically stable cobalt nanorods will not rearrange into other forms such as spherical nanoparticles or any other form . the nanoparticles that result from this embodiment exhibit magnetic properties , such as for example : i ) saturation magnetization similar to the magnetic characteristics and properties of bulk cobalt ; ii ) enhanced magnetic anisotropy and strongly enhanced coercive magnetic field ( as compared to bulk cobalt and spherical nanoparticles ) due to the shape anisotropy . the nanomaterials with enhanced magnetic properties will allow particle orientation in magnetic fields to optimize high - frequency device applications . in a preferred embodiment , the high - frequency device is fabricated into a pharmaceutical dosage form . in one embodiment , nanomaterials posses enhanced solubility properties . the nanomaterials are made from using standards known in the art . for example , a rigid poly ( aryleneethynylene ) polymer is coupled with a para - diethynyl -( r 1 — r x ) arylene and an ( r 1 — r y )- para - dih - aloarylene in the presence of a first polymerization - terminating haloaryl agent under conditions and for a period of time to produce fluorescence . then terminating the coupling by addition of a second polymerization - terminating haloaryl agent , the second haloaryl agent having equal or greater activity for coupling as compared to the ( r 1 — r y )- para - dihaloarylene . the nanomaterials with enhanced solubility will provide for functional nanomaterials that can be used for epoxy and engineering plastic composites , filters , actuators , adhesive composites , elastomer composites , materials for thermal management ( interface materials , materials for heat transfer applications ), improved dimensionally stable structures for sensorsoptoelectronic or microelectromechanical components or subsystems , rapid prototyping materials , composite fibers , etc . in a preferred embodiment , the nanomaterial is fabricated in a pharmaceutical dosage form . in a further embodiment , the nanomaterial with enhanced solubility properties is used to monitor quality of the drug product enclosed within the pharmaceutical dosage form . in one embodiment , nanomaterials are engineered for specific shapes or mechanical properties . the nanomaterials are made from using standards known in the art . for example , nanomaterials are made with modified degree of agglomeration . additionally , nanomaterials are made with a modified surface area . additionally , nanomaterials are made with post - processing to modify the phase and shape . additionally , post - processing is utilized to achieve consolidation . nanomaterials that are shape engineered are used for ceramic , metal , or composite seals on pharmaceutical dosage forms . additionally as filters with a defined porosity gradient , monitors , sensors , drug delivery devices , and biocatalysts from nanoscale powders using the multi - layer laminating process to produce three - dimensional shapes . in a preferred embodiment , the nanomaterials are used in pharmaceutical dosage forms . in a further embodiment , the nanomaterials monitor quality of drug products enclosed within the pharmaceutical dosage form . in one embodiment , nanomaterials are engineered with enhanced optical properties . the nanomaterials are made from using standards known in the art . generally , in optical lenses , the optical path length varies with distance from its center , where optical path length is defined as the product of the physical path length , thickness , and the refractive index , n , of the lens material . in the most common lenses , the refractive index , n , is fixed and the thickness , varies . however , a lens can also be created by keeping the thickness , constant and varying the refractive index as a function of distance from the axis of the lens . such a lens is called a graded index lens , or sometimes abbreviated as a grin lens . the methods of the present invention can also be used to create grin lenses . polymer / nanocrystal blends can be used to make grin lenses due to the dramatic refractive index difference between nanocrystals ( e . g ., zns about 2 . 35 ) and optical plastics such as poly ( methyl methacrylate ) ( pmma ) ( refractive index about 1 . 45 ). with normal glass , a difference of about 0 . 05 refractive index units is achievable over about 8 mm . utilizing the methods and processes of the present application , a difference of about 0 . 20 refractive index units over about 8 mm can be achieved to make much more powerful lenses . nanomaterials with enhanced optical properties can be used for contact sensors , remote sensors , lidar , optical parametric oscillators , optical data storage , optical spectroscopy , optical amplifiers , wavelength translation devices , super sensitive optical detection , and optical switches . in a preferred embodiment , the sensors with enhanced optical properties are fabricated into pharmaceutical dosage forms . in a further embodiment , the optically enhanced nanomaterials are used to monitor quality of the drug products enclosed within the pharmaceutical dosage forms described herein . in one embodiment , the invention relates to sensors that are fabricated into pharmaceutical dosage forms . in a preferred embodiment , the sensors are made from nanomaterials disclosed herein and are developed on a microscopic scale using mems ( micro - electrical - mechanical - systems ) technology . in one embodiment , the sensor is made from 1 st generation mems technology ( i . e . a sensor element mostly based on a silicon or similar structure , sometimes combined with analog amplification on a nanomaterial ). in one embodiment , the sensor is made from 2 nd generation mems technology ( i . e . a sensor element combined with analog amplification and analog - to - digital converter on one nanomaterial ). in a preferred embodiment , the sensor is made from 3 rd generation mems technology ( i . e . fusion of the sensor element with analog amplification , analog - to - digital converter and digital intelligence for linearization and temperature compensation on the same nanomaterial ). in another preferred embodiment , the sensor is made from 4 th generation mems technology ( i . e . memory cells for calibration and temperature compensation data are added to the elements of the 3 rd generation sensor ). the advantages of using sensors made out of nanomaterials is the sensors can reach significantly higher speeds and sensitivity that macroscale sensors . in addition , the scale of the pharmaceutical dosage forms disclosed herein make use of nanosensors optimal . it will be appreciated by one of skill in the art that the type of sensor needed will be a direct function to the pharmaceutical dosage form that is being used and the drug product that is being monitored . for example , monitoring the potency of a vaccine will require different monitoring parameters that monitoring the ph of an antibiotic which in turn will require different monitoring parameters that monitoring the temperature of a blood product . in these situations , it will be appreciated by one of ordinary skill that either ( i ) the same sensors can be used with different detecting criteria or ( ii ) different types of sensors can be used to achieve the best level of monitoring for a specific pharmaceutical dosage form . accordingly , sensors of the present invention comprise thermal , electromagnetic , mechanical , chemical , optical , radiation , acoustic , and biological sensors . in one embodiment , thermal sensors include but are not limited to thermometers , thermocouples , temperature sensitive resistors , bolometers , calorimeter . in a further embodiment , electromagnetic sensors include but are not limited to ohmmeters , multimeters , galvanometers , ammeters , leaf electroscopes , watt - hour meters , magnetic compasses , fluxgate compasses , magnetometers , and metal detectors . in a further embodiment , mechanical sensors include but are not limited to barometers , barographs , pressure gauges , air speed indicators , rate of change sensors , flow sensors , anemometers , flow meters , gas meters , water meters , mass flow sensors , acceleration sensors , whisker sensors , quadrature wheels , and positions switches . in a further embodiment , chemical sensors include but are not limited to oxygen sensors ( a . k . a . λ sensors ), ion - selective electrodes , ph glass electrodes , and redox electrodes . in a further embodiment , optical and radiation sensors include but are not limited to radar , lidar , dosimeters , particle detectors , scintillators , wire chambers , cloud chambers , bubble chambers , infrared sensors , photocells , photodiodes , phototransistors , image sensors ; vacuum tube devices , and proximity sensors . in a further embodiment , acoustic sensors include but are not limited to ultrasounds and sonar . in a further embodiment , biological sensors include but are not limited to biosensors that can detect physical aspects of the external environment such as light , motion , temperature , magnetic fields , gravity , humidity , vibration , pressure , electrical fields , and sound . additionally , biosensors that can detect environmental molecules such as toxins , nutrients , and pheromones are within the scope of the invention . additionally , biosensors that can detect metabolic parameters such as glucose level and oxygen level are within the scope of the invention . in another aspect , this invention also includes a method of producing an improved sensor device . a non - stoichiometric nanopowder is sonicated in a solvent to form a slurry . the slurry is brushed onto screen - printed electrodes and allowed to dry at to remove the solvent . a dissolved polymer may also be included in the slurry . the screen - printed electrodes may be gold electrodes on an alumina substrate . the screen may be made from stainless steel mesh at least 8 . times . 10 inches in size , with a mesh count of 400 , a wire diameter of 0 . 0007 inches , a bias of 45 . degree ., and a polymeric emulsion of 0 . 0002 inches . in another aspect , this invention includes an improved sensor device prepared from a screen printable paste . a nanopowder and polymer are mechanically mixed ; a screen - printing vehicle is added to the mixture and further mechanically mixed . the mixture is milled and screen - printed onto prepared electrodes . the paste is allowed to level and dry . this invention also includes the improved sensor devices produced by the above processes . in another aspect of the invention , thermal sensors are prepared from nanostructured powders . these thermal sensors can be used to monitor aspects of the pharmaceutical manufacturing process including but not limited to monitor radiation , power , heat and mass flow , charge and momentum flow , and phase transformation . in a preferred embodiment , the sensors disclosed herein are fabricated into a pharmaceutical dosage form whereby the dosage form comprise the nanomaterial or are fabricated to consist of 1 %, 2 %, 3 %, 4 %, 5 %, 6 %, 7 %, 8 %, 9 %, 10 %, 11 %, 12 %, 13 %, 14 %, 15 %, 16 %, 17 %, 18 %, 19 %, 20 %, 21 %, 22 %, 23 %, 24 %, 25 %, 26 %, 27 %, 28 %, 29 %, 30 %, 31 %, 32 %, 33 %, 34 %, 35 %, 36 %, 37 %, 38 %, 39 %, 40 %, 41 %, 42 %, 43 %, 44 %, 45 %, 46 %, 47 %, 48 %, 49 %, 50 %, 51 %, 52 %, 53 %, 54 %, 55 %, 56 %, 57 %, 58 %, 59 %, 60 %, 61 %, 62 %, 63 %, 64 %, 65 %, 66 %, 67 %, 68 %, 69 %, 70 %, 71 %, 72 %, 73 %, 74 %, 75 %, 76 %, 77 %, 78 %, 79 %, 80 %, 81 %, 82 %, 83 %, 84 %, 85 %, 86 %, 87 %, 88 %, 89 %, 90 %, 91 %, 92 %, 93 %, 94 %, 95 %, 96 %, 97 %, 98 %, or 99 % nanomaterial and the remaining ingredients of the specified dosage form are known in the art . pharmaceutical formulation is the process in which different chemical substances are combined to a pure drug substance to produce a final drug product . formulation studies involve developing a preparation of the drug which is both stable and acceptable to the patient . for orally taken drugs , this usually involves incorporating the drug into a tablet or a capsule . it is important to appreciate that a tablet contains a variety of other substances apart from the drug itself , and studies have to be carried out to ensure that the drug is compatible with these other substances . an excipient is an inactive substance used as a carrier for the active ingredients of a drug product . in addition , excipients can be used to aid the process by which a drug product is manufactured . the active substance is then dissolved or mixed with an excipient . excipients are also sometimes used to bulk up formulations with very potent active ingredients , to allow for convenient and accurate dosage . once the active ingredient has been purified , it cannot stay in purified form for very long . in many cases it will denature , fall out of solution , or stick to the sides of the container . to stabilize the active ingredient , excipients are added to ensure that the active ingredient stays active , and is stable for a long enough period of time that the shelf - life of the product makes it competitive with other products and safe for the end - user . examples of excipients , include but are not limited to , anti - adherents , binders , coatings , disintegrants , fillers , diluents , flavors , colors , lubricants , and preservatives . the final formulation comprises and active ingredient and excipients which are then enclosed in the pharmaceutical dosage form . pre - formulation involves the characterization of a drug &# 39 ; s physical , chemical , and mechanical properties in order to choose what other ingredients should be used in the preparation . formulation studies then consider such factors as particle size , polymorphism , ph , and solubility , as all of these can influence bioavailability and hence the activity of a drug . the drug must be combined with inactive additives by a method which ensures that the quantity of drug present is consistent in each dosage unit ( e . g . each tablet ). the dosage should have a uniform appearance , with an acceptable taste , tablet hardness , or capsule disintegration . it is unlikely that these studies will be complete by the time clinical trials commence . this means that simple preparations are developed initially for use in phase i clinical trials . these typically consist of hand - filled capsules containing a small amount of the drug and a diluent . proof of the long - term stability of these formulations is not required , as they will be used ( tested ) in a matter of days . however , long - term stability is critical in supply chain management since the time the final formulation is packaged until it reaches the patient can be several months or years . in addition , the location of the patient in relation to the packaging of the drug product influences quality factors . consideration has to be given to what is called the drug load ( i . e . the ratio of the active drug to the total contents of the dose ). a low drug load may cause homogeneity problems . a high drug load may pose flow problems or require large capsules if the compound has a low bulk density . by the time phase iii clinical trials are reached , the formulation of the drug should have been developed to be close to the preparation that will ultimately be used in the market . a knowledge of stability is essential by this stage , and conditions must have been developed to ensure that the drug is stable in the preparation . if the drug proves unstable , it will invalidate the results from clinical trials since it would be impossible to know what the administered dose actually was . stability studies are carried out to test whether temperature , humidity , oxidation , or photolysis ( ultraviolet light or visible light ) have any effect , and the preparation is analysed to see if any degradation products have been formed . it is also important to check whether there are any unwanted interactions between the preparation and the container . if a plastic container is used , tests are carried out to see whether any of the ingredients become adsorbed on to the plastic , and whether any plasticizers , lubricants , pigments , orstabilizers leach out of the plastic into the preparation . even the adhesives for the container label need to be tested , to ensure they do not leach through the plastic container into the preparation . the way a drug is formulated can avoid some of the problems associated with oral administration . drugs are normally taken orally as tablets or capsules . the drug ( active substance ) itself needs to be soluble in aqueous solution at a controlled rate . such factors as particle size and crystal form can significantly affect dissolution . fast dissolution is not always ideal . for example , slow dissolution rates can prolong the duration of action or avoid initial high plasma levels . accordingly , in one embodiment , the nanomaterials of the invention are fabricated into the pharmaceutical dosage form whereby the nanomaterials are used to monitor quality of the drug product enclosed within the dosage form from the point of packaging until use by the end - user . in a further embodiment , the nanomaterials of the invention are fabricated into a pharmaceutical dosage form whereby the nanomaterials are used to monitor ph levels of the drug product . in a further embodiment , the nanomaterials of the invention are fabricated into a pharmaceutical dosage form whereby the nanomaterials are used to monitor temperature levels of the drug product . in a further embodiment , the nanomaterials of the invention are fabricated into a pharmaceutical dosage form whereby the nanomaterials are used to monitor stability of the drug product . in a further embodiment , the nanomaterials of the invention are fabricated into a pharmaceutical dosage form whereby the nanomaterials are used to monitor oxidation of the drug product . in a further embodiment , the nanomaterials of the invention are fabricated into a pharmaceutical dosage form whereby the nanomaterials are used to monitor degradation of the drug product . in a further embodiment , the nanomaterials of the invention are fabricated into a pharmaceutical dosage form whereby the nanomaterials are used to monitor leachates of the drug product . in a further embodiment , the nanomaterials of the invention are fabricated into a pharmaceutical dosage form whereby the nanomaterials are used to monitor potency of the drug product . in a further embodiment , the nanomaterials of the invention are fabricated into a pharmaceutical dosage form whereby the nanomaterials are used to monitor cold chain requirements of the drug product . a dosage form is the physical form of a dose of a drug product , such as a capsule or injection . table i summarizes the generally recognized dosage forms . the route of administration ( see , section vi . entitled “ route of administration ”) is dependent on the dosage form of a given drug . various dosage forms may exist for the same compound , since different medical conditions may warrant different routes of administration . for example , persistent vomiting may make it difficult to use an oral dosage form . in this case , it may be advisable to use either an injection or a suppository . also , specific dosage forms may be warranted for certain medications , since there may be problems with stability ( e . g . insulin cannot be given orally since it is digested by the stomach ). in the packaging of pharmaceuticals , encapsulation refers to a range of techniques used to enclose medicines in a relatively stable shell , allowing them to , for example , be taken orally or be used as suppositories . the two main types of capsules are hard - shelled capsules , which are normally used for dry , powdered ingredients , and soft - shelled capsules , primarily used for oils and for active ingredients that are dissolved or suspended in oil . both of these classes of capsule are made both from gelatine and from plant - based gelling substances like carrageenans and modified forms of starch and cellulose . since their inception , capsules have been viewed as the medium of more potent medicines than tablets , which are more commonly associated with weaker over - the - counter drugs . a tablet is usually a compressed preparation that contains , 5 - 10 % of the drug ( active substance ); 80 % of fillers , disintegrants , lubricants , glidants , and binders ; and 10 % of compounds which ensure easy disintegration , disaggregation , and dissolution of the tablet in the stomach or the intestine . the disintegration time can be modified for a rapid effect or for sustained release . special coatings can make the tablet resistant to the stomach acids such that it only disintegrates in the duodenum as a result of enzyme action or alkaline ph . pills can be coated with sugar , varnish , or wax to diguise the taste . some tablets are designed with an osmotically active core , surrounded by an impermeable membrane with a pore in it . this allows the drug to percolate out from the tablet at a constant rate as the tablet moves through the digestive tract . an injection is a method of putting liquid into the body with a hollow needle and a syringe which is pierced through the skin long enough for the material to be forced into the body . an emulsion is a mixture of two immiscible ( unblendable ) substances . one substance ( the dispersed phase ) is dispersed in the other ( the continuous phase ). examples of emulsions include propofol , among others . emulsions tend to have a cloudy appearance , because the many phase interfaces scatter light that passes through the emulsion . emulsions are unstable and thus do not form spontaneously . energy input through shaking , stirring , homogenizers , or spray processes are needed to form an emulsion . over time , emulsions tend to revert to the stable state of oil separated from water . surface active substances can increase the kinetic stability of emulsions greatly so that , once formed , the emulsion does not change significantly over years of storage . this phenomenon is called coalescence , and happens when small droplets recombine to form bigger ones . fluid emulsions can also suffer from creaming , the migration of one of the substances to the top of the emulsion . other types of non - limiting dosage forms within the scope of the present invention are set forth in table i . in one embodiment , the nanomaterials of the invention are fabricated into a pharmaceutical dosage form whereby the nanomaterials are used to monitor quality parameters of the drug product enclosed therein . in a further embodiment , the nanomaterials of the invention are fabricated into a pharmaceutical dosage form set forth in table i whereby the nanomaterials are used to monitor quality parameters of the drug product enclosed therein . in a preferred embodiment , the nanomaterials disclosed herein are fabricated into a pharmaceutical dosage form set forth in table i whereby the dosage form comprise the nanomaterial or are fabricated to consist of 1 %, 2 %, 3 %, 4 %, 5 %, 6 %, 7 %, 8 %, 9 %, 10 %, 11 %, 12 %, 13 %, 14 %, 15 %, 16 %, 17 %, 18 %, 19 %, 20 %, 21 %, 22 %, 23 %, 24 %, 25 %, 26 %, 27 %, 28 %, 29 %, 30 %, 31 %, 32 %, 33 %, 34 %, 35 %, 36 %, 37 %, 38 %, 39 %, 40 %, 41 %, 42 %, 43 %, 44 %, 45 %, 46 %, 47 %, 48 %, 49 %, 50 %, 51 %, 52 %, 53 %, 54 %, 55 %, 56 %, 57 %, 58 %, 59 %, 60 %, 61 %, 62 %, 63 %, 64 %, 65 %, 66 %, 67 %, 68 %, 69 %, 70 %, 71 %, 72 %, 73 %, 74 %, 75 %, 76 %, 77 %, 78 %, 79 %, 80 %, 81 %, 82 %, 83 %, 84 %, 85 %, 86 %, 87 %, 88 %, 89 %, 90 %, 91 %, 92 %, 93 %, 94 %, 95 %, 96 %, 97 %, 98 %, or 99 % nanomaterial and the remaining ingredients of the specified dosage form are known in the art . a route of administration is the path by which a drug , fluid , or other substance is brought into contact with the body . as one of ordinary skill in the art will appreciate , a substance must be transported from the site of entry to the part of the body where its action is desired to take place . however , using the body &# 39 ; s transport mechanisms for this purpose can be far from trivial . the pharmacokinetic properties of a drug are critically influenced by the route of administration . routes of administration can broadly be divided into three categories . topical , wherein a local effect is desired . a substance is applied directly where its action is desired . enteral , wherein the desired effect is systemic ( non - local ). an example is a substance is given via the digestive tract . parenteral , wherein the desired effect is systemic . a substance is given by other routes than the digestive tract ( i . e . injection ). table ii summarizes the general routes of administration . proper supply chain management of packaged pharmaceuticals is critical to provide quality drugs to end - users . this includes monitoring traditional areas of supply chain to include packaging , product protection , storage , and distribution . in addition , monitoring the cold chain ( i . e . a subset of the supply chain that require temperature control ) in order to retain drugs key properties is vital . specifically , from the point when the drug product is packaged until it reaches the end - user ( see , fig6 ). depending on the geographic location of the end - user and circumstances surrounding the need for treatment ( i . e . a natural disaster ), this could take weeks , months , etc . additionally , not all cold chain products are the same and the need for monitoring temperature and other quality parameters differs for each type of drug product . table iii sets forth the generally recognized categories of temperatures in cold chain compliance . in addition , table iv shows general consequences of what happens to drug products when cold chain management fails . in one embodiment , the invention provides for a method of monitoring quality of a drug product whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the nanomaterial monitors the quality parameters set for the quality control unit . in a further embodiment , the invention provides for a method of monitoring quality of a drug product whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the monitoring occurs from packaging to distribution ( see , fig6 ). in a further embodiment , the invention provides for a method of monitoring quality of a drug product whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the monitoring occurs from distribution to wholesale ( see , fig6 ). in a further embodiment , the invention provides for a method of monitoring quality of a drug product whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the monitoring occurs from wholesale to retail ( see , fig6 ). in a further embodiment , the invention provides for a method of monitoring quality of a drug product whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the monitoring occurs from retail to the end user ( see , fig6 ). in a preferred embodiment , the invention provides for a method of monitoring quality of a drug product in a cold chain whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the temperature monitoring occurs from packaging to the end user ( see , fig6 ). for use in monitoring quality of drug products enclosed within pharmaceutical dosage forms ( table i ) described herein , kits are within the scope of the invention . such kits can comprise a carrier , package , or container that is compartmentalized to receive one or more containers such as boxes , shrink wrap , and the like , each of the container ( s ) comprising one of the separate elements to be used in the method , along with a program or insert comprising instructions for use , such as a use described herein . the kit of the invention will typically comprise the container described above and one or more other containers associated therewith that comprise nanomaterials fabricated into pharmaceutical dosage forms desirable from a commercial and user standpoint , listing contents and / or instructions for use , and package inserts with instructions for use . a program can be present on or with the container . directions and or other information can also be included on an insert ( s ) or program ( s ) which is included with or on the kit . the program can be on or associated with the container . the terms “ kit ” and “ article of manufacture ” can be used as synonyms . the article of manufacture typically comprises at least one container and at least one program . the containers can be formed from a variety of materials such as glass , metal or plastic . various aspects of the invention are further described and illustrated by way of the several examples that follow , none of which is intended to limit the scope of the invention . the nanomaterial with enhanced thermal conductivity is generated by methods known in the art . the nanomaterial is formed into sheets providing an interface between the thermal pad and the drug product and providing an interface between the thermal pad and a thermal biosensor . ( fig1 ). in one embodiment , the nanomaterial is fabricated into a pre - filled syringe . the thermal biosensor monitors temperature of the drug product enclosed therein ( e . g . a vaccine ). when the temperature falls outside the pre - set parameter ( s ) a schema notifies the end - user ( e . g . doctor , patient , nurse , etc .) and the dosage form is discarded or corrective action is taken . ( fig2 ). in one embodiment , the monitoring and quality assessment achieves a step of supply chain management whereby drug product quality and shelf - life are increased . costs are reduced over time . in a further embodiment , the monitoring and quality assessment achieves a step of cold chain management whereby drug product quality and shelf - life are increased . costs are reduced over time . quality monitoring of drug product using nanomaterials with enhanced luminescent properties the nanomaterial with enhanced luminescent properties is generated by methods known in the art . dosage forms fabricated with the nanomaterials are produced by standard methods and a drug product is enclosed therein . sensors monitor such properties as ph , temperature , degradation , potency , solubility , and other properties affecting drug product efficacy . when the pre - set property falls outside the quality parameter ( s ) a schema notifies the end - user ( e . g . doctor , patient , nurse , etc .) and the dosage form is discarded or corrective action is taken . in one embodiment , the schema comprises a color change in the dosage form . in one embodiment , the schema comprises a symbol display on the dosage form . in one embodiment , the schema comprises a word display on the dosage form . ( fig3 ). the nanomaterial with enhanced optical properties is generated by methods known in the art . the nanomaterial is formed into graded index lens whereby the thickness of the lens is uniform providing an optimal interface between the contact lens the dosage form and the optical fiber . ( fig4 ). in one embodiment , the nanomaterial is fabricated into a dosage form enclosing an emulsion . an emulsion is a mixture of two or more immiscible ( unblendable ) substances . one substance ( the dispersed phase ) is dispersed in the other ( the continuous phase ). emulsions tend to have a cloudy appearance , because the many phase interfaces scatter light that passes through the emulsion . emulsions are unstable and thus do not form spontaneously . energy input through shaking , stirring , homogenizers , or spray processes are needed to form an emulsion . over time , emulsions tend to revert to a stable state . additionally , surface active substances can increase the kinetic stability of emulsions greatly so that , once formed , the emulsion does not change significantly over years of storage . however , some emulsions are so unstable that they will quickly separate unless continuous energy is applied . fluid emulsions can also suffer from creaming , the migration of one of the substances to the top of the emulsion under the influence of buoyancy . emulsions are part of a more general class of two - phase systems of matter called colloids . although the terms colloid and emulsion are sometimes used interchangeably , emulsion tends to imply that both the dispersed and the continuous phase are liquid . there are three types of emulsion instability , ( i ) flocculation , where the particles form clumps ; ( ii ) creaming , where the particles concentrate towards the surface ( or bottom , depending on the relative density of the two phases ) of the mixture while staying separated ; and ( iii ) breaking and coalescence where the particles coalesce and form a layer of liquid . accordingly , the contact lens monitors phase transformation of the emulsion enclosed within the dosage form . when the phase transition falls outside the pre - set parameter ( s ) the end - user ( e . g . doctor , patient , nurse , etc .) provides a visual inspection and the dosage form is discarded or corrective action is taken . ( fig5 ). in one embodiment , the monitoring and quality assessment achieves a step of supply chain management whereby drug product quality and shelf - life are increased . costs are reduced over time . in a further embodiment , the monitoring and quality assessment achieves a step of cold chain management whereby drug product quality and shelf - life are increased . costs are reduced over time . methods of monitoring quality of drug product using dosage forms fabricated with nanomaterials the final formulation of the drug product is determined and is packaged using standards methods known in the art into dosage forms fabricated with nanomaterials . the dosage forms comprise a detection schema to notify end - users ( doctors , patients , hospitals , etc .) when the drug product properties being monitored fall outside the quality protocol . in one embodiment , the invention provides for a method of monitoring quality of a drug product whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the nanomaterial monitors the quality parameters set for the quality control unit . in a further embodiment , the invention provides for a method of monitoring quality of a drug product whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the monitoring occurs from packaging to distribution ( see , fig6 ). in a further embodiment , the invention provides for a method of monitoring quality of a drug product whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the monitoring occurs from distribution to wholesale ( see , fig6 ). in a further embodiment , the invention provides for a method of monitoring quality of a drug product whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the monitoring occurs from wholesale to retail ( see , fig6 ). in a further embodiment , the invention provides for a method of monitoring qualify of a drug product whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the monitoring occurs from retail to the end user ( see , fig6 ). in a preferred embodiment , the invention provides for a method of monitoring quality of a drug product in a cold chain whereby the dosage form comprises a nanomaterial fabricated into the dosage form and whereby the temperature monitoring occurs from packaging to the end user ( see , fig6 ). table iii shows generally recognized temperatures in cold chain compliance . in one embodiment , the monitoring achieves a step of supply chain management whereby drug product quality and shelf - life are increased . costs are streamlined over time . the present invention is not to be limited in scope by the embodiments disclosed herein , which are intended as single illustrations of individual aspects of the invention , and any that are functionally equivalent are within the scope of the invention . various modifications to the models and methods of the invention , in addition to those described herein , will become apparent to those skilled in the art from the foregoing description and teachings , and are similarly intended to fall within the scope of the invention . such modifications or other embodiments can be practiced without departing from the true scope and spirit of the invention . results when drug products recommended to be stored at 15 °- 25 ° c . are
nanomaterials fabricated to pharmaceutical dosage forms used to monitor quality of the drug product enclosed therein are disclosed . the nanomaterials are useful to provide a plurality of quality analysis to the dosage form . consequently , the nanomaterials provide a means to perform quality testing on a continuous basis throughout the supply chain , including the cold chain whereby manufacturers and distributors can achieve greater product integrity and longer shelf life and ultimately minimize cost . the end user benefits in obtaining the highest quality drugs at the time of need .