although the following text sets forth a detailed description of numerous different embodiments , it should be understood that the legal scope of the description is defined by the words of the claims set forth at the end of this disclosure . the detailed description is to be construed as exemplary only and does not describe every possible embodiment since describing every possible embodiment would be impractical , if not impossible . numerous alternative embodiments could be implemented , using either current technology or technology developed after the filing date of this patent , which would still fall within the scope of the claims . an aspect of the invention is directed to a composition . the composition comprises selenium , digestive enzymes dpp - iv , proteolytic enzyme , systemic enzyme , selenium , and antioxidants glutathione . other components can be included in the composition . certain individuals have a genetic mutation or a single nucleotide polymorphism ( snp — pronounced snip ), which causes difficulty in converting hydrogen peroxide to its harmless byproducts . the enzyme that makes this conversion is called “ catalase ” and in supplemental form can break down peroxide . people with hashimoto &# 39 ; s have elevated levels of peroxide that must be quelled . catalase reduces oxidative stress by breaking down a potent free radical toxin called hydrogen peroxide which cells naturally produce each day . in patients with hashimoto &# 39 ; s thyroidits , there is an enormous amount of “ lipid peroxidation ,” which is a scientific term describing the destruction ( or peroxidation ) of cell membranes . lipid preoccupation is the oxidative breakdown of lipids ( fats ). it is the process in which free radicals take electrons from the fats in cell membranes , resulting in cell damage . this process is proceeded by a free radical chain reaction mechanism . it spawns a lot of harmful cytokines , namely hydrogen peroxide . catalase directly breaks down hydrogen peroxide , rendering it harmless by turning it into water and oxygen . in some embodiments , the composition further comprises a pre - determined amount of catalase . the human body requires catalase to convert the free radical “ hydrogen peroxide ” into harmless water and oxygen . without enough catalase , the body will begin to “ rust ” and the hair may turn grey and the build - up of peroxides will increase damage to the cells , in particular the cell membranes of the thyrocytes ( thyroid cells ). people who are deficient in iron or niacin ( due to drinking coffee , or taking ibuprofen or aspirin ) may have insufficient levels of catalase enzyme activity . people with genetic snps may also be deficient in catalase . in some embodiments , the composition can comprise from about 25 to 1 , 000 mg of catalase . in a preferred embodiment , the composition can comprise about 250 mg of catalase . people with hashimoto &# 39 ; s have a difficult time digesting food , especially proteins . in some embodiments , the composition can include at least one digestive enzyme . the compound can include a pre - determined amount of “ dipeptidyl peptidase 4 ” or dpp - iv . it has been found from experimentation that dpp - iv reduces absorption of gluten and casein , two proteins found in wheat and dairy , respectively . as gluten and casein are known to attack and damage the thyroid glands of certain individuals , and set forth autoimmune attacks within the human body , it is desirable to include a pre - determined amount of dpp - iv within the composition . in addition , certain individuals have a deficiency in this enzyme , and therefore have trouble breaking down gluten and casein protein . partial digestion of these food proteins will leak through the highly permeable intestinal lining , and travel through the bloodstream ultimately provoking an immune response . when these molecules land in or near the thyroid gland , there is an autoimmune thyroid assault . the composition can include from about 10 to 1 , 000 mg of dpp - iv . in some embodiments , the composition can include about 100 mg of dpp - iv . in some embodiments , one or more additional digestive enzymes are included or substituted for dpp - iv . suitable digestive items , for examples of dpp - ivs include , but are not limited to , amylase , cellulose , phytase , lactase , sucrose , lipase , and combinations thereof . the human body forms antibodies to the various proteins which are also the same exact antibodies that could target the thyroid gland during hashimoto &# 39 ; s disease . when a person eats food , and the undigested food proteins and particles lodge in or around the thyroid gland , then the immune system launches an attack . these poorly digested protein / food particles become fuel for opportunistic bacteria and yeast that live in the gut microbiome . an overgrowth of these opportunistic infections leads to more gastrointestinal symptoms . studies have shown that overgrowth of opportunistic bacteria are tied to autoimmune dysfunction of the thyroid gland . hashimoto &# 39 ; s symptoms increase due to the unregulated influx of pro - inflammatory ( pain - causing ) chemicals that leave the gut and travel throughout the bloodstream , potentially lodging in the thyroid gland . in some embodiments , the composition further can comprise a pre - determined amount of pepsin , which can be animal or vegetable derived . pepsin is a protein - digesting enzyme known as “ proteases ,” whose function is to break down large proteins into their smaller particles called peptides . pepsin has been found through experimentation to assist in the reduction of auto - antibodies aimed at the thyroid gland , so indirectly , enzymes promote a healthy thyroid function . the composition can comprise from about 10 to 50 mg of pepsin . in some embodiments , the composition can include about 20 mg of pepsin . thyroid disorders are characterized by increased inflammation in the body and in the case of hashimoto &# 39 ; s thyroiditis , there is a tremendous amount of inflammation around the thyroid tissue itself . bromelian helps reduce inflammation . bromelain is not a single substance , but rather a collection of protein - digesting enzymes and other compounds . it is a proteolytic enzyme that works to modulate ( or coordinate ) the activity of inflammatory immune complexes . proteolytic enzymes have an affinity for immune complexes that would otherwise travel through the blood stream and increase inflammatory chemical ( called cytokines ) such as tumor necrosis factor ( tnf ) and c reactive protein ( crp ). bromelian can reduce the reactivity of the immune complexes , which come from undigested food particles , and simultaneously reduced production of pro - inflammatory cytokines . the composition can comprise a pre - determined amount of bromelain . the enzyme can be derived from pineapples and has been discovered through experimentation to be a desirable method of reducing inflammation . in some embodiments , the composition comprises from about 50 to 500 mg of bromelain . in some embodiments , the composition can comprise about 250 mg of bromelain . clearly , with hashimoto &# 39 ; s disease , there is a need for additional support in food metabolism and breakdown . increased intestinal permeability ( commonly termed “ leaky gut syndrome ”) is associated with autoimmune disease . in fact , reversing symptoms of autoimmune disease , including hashimoto &# 39 ; s depends on healing the lining of the gastrointestinal tract . drug treatment only seeks to suppress symptoms , not heal the gut or reduce the problem of undigested food particles , which leave the gut and travel throughout the bloodstream . with hashimoto &# 39 ; s , the body makes antibodies to the thyroid gland . pancreatin is a pancreatic enzyme that reduces the burden that the body has to face from partially digested food particles that leaves the “ leaky gut .” pancreatin is a digestive enzyme that supports food metabolism . the composition can include a pre - determined amount of pancreatin enzymes . through experimentation it has been discovered that undigested food proteins which lead to thyroid autoimmunity are minimized or eliminated by pancreatin , a digestive enzyme that is naturally produced in the body by the exocrine cells of the human pancreas . pancreatin might help to lessen the antigenic load or toxic molecules being presented on the intestinal lining and bloodstream . pancreatin is not a single enzyme but rather it is composed of amylase , lipase and protease , which breaks down carbohydrates , fats and proteins , respectively . studies show that supplementation of pancreatin can help with autoimmune dysfunction . pancreatin can also be useful for flatulence , cystic fibrosis or chronic pancreatitis . with respect to thyroid function and hashimoto &# 39 ; s , pancreatin may help suppress antigenic load from undigested food particles that have migrated through the leaky gut into the bloodstream and / or thyroid tissue . the composition can include from about 50 to 500 mg of pancreatin . in some embodiments , the composition comprises about 200 mg of pancreatin enzyme . studies show a tight correlation with vitamin d deficiency and autoimmune diseases of many sorts including hashimoto &# 39 ; s . researchers in south korea , in 2013 looked at vitamin d levels and how they correlated with the presence of the antibody tpo - ab ( antibodies to tpo , a biomarker for hashimoto &# 39 ; s ). the presence of tpo - ab signals that the body has or has had an attack on the thyroid . the researchers looked at 6 , 685 patients between 2008 and 2012 . all participants had their blood drawn , so the researchers could measure both tpo - ab and vitamin d levels . the researchers divided patients into three different categories , those who were severely deficient in vitamin d ( had levels less than 10 ng / ml ), deficient in vitamin d ( levels between 10 - 30 ng / ml ) and those who were sufficient in vitamin d ( over 30 ng / ml ). those who were deficient in vitamin d were much more likely to have tpo - ab positive tests ( a biomarker confirming hashimoto &# 39 ; s thyroiditis ). the prevalence of tpo - ab positive tests was 21 . 2 % in the severely vitamin d deficient group , 15 . 5 % in the deficient group , and just 12 . 6 % in the sufficient group . participants who lacked vitamin d more than normal , had the highest autoantibody levels against the thyroid gland . simply put , those with the lowest levels of vitamin d had the most destruction of their thyroid gland occurring . in a preferred embodiment , the composition further comprises a pre - determined amount of vitamin d , a natural fat - soluble antioxidant produced in the human body from ultraviolet ray ( sun ) exposure . vitamin d is known to promote a healthy immune system , and is particularly useful for autoimmune conditions . as it pertains to thyroid health and autoimmune thyroid conditions , vitamin d is the primary antioxidant to protect the thyroid gland . the composition can include from about 1 , 000 to 10 , 000 iu of vitamin d3 ( cholecalciferol ). in some embodiments , the composition can include about 4 , 000 iu vitamin d3 ( cholecalciferol ). glutathione is one of the human body &# 39 ; s most powerful antioxidant and is produced naturally in the liver , and released to be used throughout the entire system . as one function , glutathione protects dna from damage and is critical for proper mitochondrial function and energy production . if the mitochondria are damaged , you will feel more fatigue and you can &# 39 ; t detoxify poisons from your cells . glutathione can be taken in supplementation form . there are a lot of benefits to taking glutathione orally , however , taken alone in a regular form will cause it to be of little use . glutathione rapidly degrades once it enters the stomach where the gastric ( hydrochloric acid ) dissolves the glutathione molecule before it can be absorbed . acetyl glutathione is used to help overcome the problems with absorption . increasing the amount of glutathione that reaches the cells , this acetylated form permeates the barriers that once held back the benefits of supplementing glutathione orally . the “ acetylated ” form can bypass stomach acid , thus improving bioavailability . s - acetyl glutathione can be included in the composition to ensure optimum absorption . “ reduced ” glutathione is the natural form produced by the body , and can also be included in the composition . aside from detoxifying poison from the cell , glutathione has been shown through experimentation to break down ( metabolize ) hydrogen peroxide which is high in people with hashimoto &# 39 ; s disease . by neutralizing peroxide in the body , free radical damage is reduced . glutathione is a potent “ heavy metal ” chelator and can help clear the body of mercury , cadmium , lead and other heavy metals . people with hashimoto &# 39 ; s may have elevated levels of heavy metals as part of their disease , so the enhanced clearance of heavy metals is desired . glutathione supports immune function . it also has natural antiviral activity . a poor diet or poor intestinal permeability , as well as chronic illness will deplete human stores of glutathione and inhibit its production . the body &# 39 ; s ability to make glutathione declines naturally with age . individuals over the age of 45 are especially likely to be deficient . acetyl glutathione benefits every system in the body , and truly earns the title of our body &# 39 ; s “ master antioxidant ” as many people refer to it . therefore , the composition can include from about 10 to 200 mg of s - acetylglutathoine ( sag ). in some embodiments , the composition can include about 50 mg of sag . in some embodiments , sag can be in a reduced form . reduced sag can get into the blood - brain barrier . in some embodiments , the composition can include a predetermined amount of “ reduced ” glutathione , which means it is in the form that is recognized and absorbed by the cells of the body . the combination of both forms of glutathione provides optimal absorption , and synergetic effects . reduced l - glutathione is a natural compound made in the body from the amino acids glutamic acid , cysteine and glycine . reduced glutathione is an antioxidant that protects cells and tissues by scavenging free radicals . in this process , reduced glutathione is transformed into the oxidized form . however , reduced glutathione can quickly be depleted under heavy bouts of free radical stress or exposure to compounds that require detoxification . a shift in the ratio towards the oxidized state leaves cells and tissues vulnerable to free radical damage and inflammation . the “ l ” designation indicates the natural molecular structure . the composition can include from about 100 to 500 mg of “ reduced ” glutathione . in some embodiments , the composition can include comprises about 250 mg of “ reduced ” glutathione . the composition can include a pre - determined amount of selenium . ideally , selenium should be supplemented in a form in which it occurs naturally in foods . although there are various forms of the mineral selenium , such as sodium selenite , which can be used for selenoprotein biosynthesis , only “ selenomethionine ” is incorporated into body proteins . selenomethionine is a natural form of selenium . because the l - isomer of selenomethionine ( termed in the literature as se - met ) is a major natural food - form of selenium , it is used in the composition , though one skilled in the art would understand that equivalent forms can be used without deviating from the invention . this form of selenium can be stored in the human and reversibly released by normal metabolic processes , thus offering an advantage over other selenium salts . ingested selenomethionine is absorbed in the small intestine and helps with thyroid hormone production , conversion and utilization . selenium is a popular compound used in thyroid support formulas since it is an antioxidant mineral and is essential for the deiodinase enzymatic system . the deiodinase enzyme converts t4 ( inactive ) to t3 ( active ) thyroid hormone . certain selenium - dependent deiodinase enzymes therefore activate human thyroid hormone . deficiency of selenium would result in reduced active t3 levels . deficiency in selenium could result in clinical hypothyroidism . the composition can include from about 10 to 400 mcg of selenium . in some embodiments , the composition comprises about 100 mcg of selenium . in varying embodiments , the composition can be substantially free of gluten , wheat , egg , peanuts , tree nuts , dairy , sugar , corn , soy , artificial colors , preservatives , fish and shellfish , and combinations thereof . according to certain embodiments , the compositions described herein can further be provided with one or more palatability agents . these palatability agents serve to add flavor to the composition so that an effective dosage is easier to be ingested by a patient . it is within the scope of the present invention that any safe , flavor enhancing palatability agent can be used in a composition of the present invention . particularly suitable palatability agents for use in the composition of the present invention include , but are not limited to , plant oils , plant hydrolysates , yeast , and yeast hydrolysates , and combinations thereof . an aspect of the invention is a method to treat a thyroid disease with a composition comprising selenium , digestive enzymes dpp - iv , proteolytic enzyme , systemic enzyme , and glutathione . the composition can include other components such as catalase , antioxidants , and pepsin , along with palatability components . the patient is treated by providing an effective amount of the composition to affect the thyroid . the capsules can be taken by the patient daily , preferably in the morning before any other food is ingested by the patient . the capsule can be acid resistant or enteric - coated capsule , soft gel or tablet . in some embodiments , the dosage can be adjusted to result in an adequate thyroid level in the patient . in some embodiments , the disease can be hashimoto &# 39 ; s . an aspect of the invention is a method to prepare a composition . the method comprises providing proportional amounts of each component such that the resulting composition results containing from about 100 to 500 mg reduced glutathione , from about 10 to 200 mg of acetylated glutathione , from about 10 to 1 , 000 mg dpp - iv enzyme , from about 50 to 500 mg bromelain , from about 50 to 500 mg pancreatin enzyme , and from about 25 to 200 mcg of selenium . in some embodiments , the composition can further include from about 25 to 1 , 000 mg catalase , from about 10 to 50 mg pepsin , from about 1 , 000 to 10 , 000 iu vitamin d . the components are mixed , then can be provided to a delivery device ( for example capsule or a powder ). the capsule can be acid resistant or enteric - coated capsule , soft gel or tablet . ranges have been discussed and used within the forgoing description . one skilled in the art would understand that any sub - range within the stated range would be suitable , as would any number within the broad range , without deviating from the invention . while various embodiment of the present disclosure have been described in detail , it is apparent that modifications and alterations of those embodiments will occur to those skilled in the art . however , it is to be expressly understood that such modifications and alterations are within the scope and spirit of the present disclosure , as set forth in the following claims . for further illustration , the book “ thyroid healthy ” authored by the named inventor of the present invention is expressly made a part of this disclosure and incorporated by reference herein in their entirety . the foregoing discussion of the disclosure has been presented for purposes of illustration and description . the foregoing is not intended to limit the disclosure to the form or forms disclosed herein . in the foregoing detailed description for example , various features of the disclosure are grouped together in one or more embodiments for the purpose of streamlining the disclosure . this method of disclosure is not to be interpreted as reflecting an intention that the claimed disclosure requires more features than are expressly recited in each claim . rather , as the following claims reflect , inventive aspects lie in less than all features of a single foregoing disclosed embodiment . thus , the following claims are hereby incorporated into this detailed description , with each claim standing on its own as a separate preferred embodiment of the disclosure .
the present disclosure relates to a compound and method of using such compound , preferably in the form of a dietary supplement that , when administered , is capable of treating thyroid disease and various thyroid - related disorders , such as hashimoto &# 39 ; s thyroiditis . the unique combination of the composition is preferably administered orally via acid resistant or enteric - coated capsule , soft gel or tablet . the composition is preferably comprised of at least catalase , reduced glutathione , acetylated glutathione , dpp - iv protease enzyme , pepsin , bromelain , pancreatin , vitamin d , and selenium . the composition can further comprise a palliative agent , and can be provided in specific dosages or administered in forms besides those listed above .