the present invention is directed to a method for producing mists that uses an approach different from methods currently in use , i . e ., jet nebulization and ultrasonic nebulization . in particular , mists are produced by a device that releases a mixture containing a pressurized gas and a pressurized liquid through an orifice with a diameter in the micrometer range . when the mixture escapes from the orifices , the decompressed gas rapidly expands its volume up to 1244 times and breaks the liquid stream escaping from the orifices into tiny droplets . pressure in the device is created by means of a high pressure pump which may take the form of any of the many types known in the art . in a preferred embodiment shown in fig2 , the pump has a motor that is connected to a wheel ( i ) that pushes a piston ( 5 ) by means of a lever ( 2 ). the housing ( 4 ) of the high pressure pump ( 29 ) holds oil ( 3 ) that lubricates the joints of the lever and piston . a diaphragm ( 28 ) separates the piston ( 5 ) from the pump chamber ( 6 ) and prevents oil from contaminating the high pressure compartment ( 30 ). when the piston retracts , it generates a negative pressure in the pump chamber ( 6 ) and gas or liquid is drawn from either the gas pipe ( 11 ) or the liquid pipe ( 10 ) through one - way valves ( 8 ) and ( 9 ). when the piston moves forward , it pushes the liquid or gas through the one - way valve ( 7 ) into the high pressure compartment ( 30 ) of the gas / liquid container ( 39 ). when the liquid level in the high pressure compartment reaches level sensor ( 15 ), a signal is sent to switch ( 33 ) on the liquid pipe ( 10 ) to close the one - way valve ( 9 ) and , as a result , only gas is pumped into the high pressure compartment . if the liquid level falls below the level sensor ( 15 ), switch ( 33 ) opens valve ( 9 ) and switch ( 34 ) on the gas pipe ( 11 ) shuts off one - way valve ( 8 ). thus , only liquid is pumped into the high pressure container under these circumstances . the pump will keep running until the high pressure compartment ( 30 ) reaches a target pressure as measured by a pressure gauge ( 16 ). at that point , the gauge will signal the pump to stop operation . as a safety feature , the high pressure compartment ( 30 ) includes a pop off valve ( 19 ) that releases pressure if it becomes unacceptably high . the gas and liquid mixture within the high pressure compartment is continually mixed to prevent these components from separating from each other . this may be accomplished by any means known in the art , but one preferred method shown in fig2 is by means of an electronically operated mixing blade ( 18 ). in the high pressure compartment ( 30 ), the mixture ( 17 ) of gas and liquid is pressurized from about 2 atmospheres up to the critical pressure of the gas , at which point the gas component either is converted from its gas phase into its liquid phase or dissolves in the liquid in very high concentration . when this mixture is forced through orifices ( 20 ) into a low pressure compartment ( 40 ) of the gas / liquid container ( 39 ), there is a sudden reduction in pressure . this causes an expansion of the volume of the gas component of the mixture present in either gas or liquid phase . in contrast , the liquid component of the mixture will remain in liquid phase and its volume will not change appreciably despite the sudden reduction in pressure at the orifice . nevertheless , the sudden expansion of the gas volume together with the high speed of the mixture being forced through the orifice breaks the liquid into tiny droplets , thereby forming a mist ( 21 ). due to the evaporation energy caused by the gas , the temperature of the mixture at the orifice will be reduced and the liquid component may be released either as cold droplets or cold solid particles , i . e ., ice crystals . in order to prevent liquid from freezing at the orifices and to control the temperature of the mist generated , the orifice walls ( 31 ) are heating elements that maintain a desired temperature , i . e ., 1 ° c . the output ( volume per unit of time ) of mist produced can be controlled by means of a switch ( 32 ) that changes the number of orifices in the open state without altering the pressure gradient at the orifices . the volume ratio of the mist ( volume of liquid / volume of gas ) can be controlled by altering the pressure in the high pressure compartment ( 30 ) ( the higher the pressure , the denser the gas in the container , the larger the expansion at the orifices and the lower the volume ratio of the mist ). the size of the droplets in the mist can be controlled by changing the diameters of the orifices and / or the pressure gradient between the high pressure compartment and low pressure compartment ( the smaller the diameter of the orifices and / or the higher the pressure gradient , the smaller the size of the droplets ). the mist is directed to an interface ( not shown in the drawings ) between the mist generator and the mist utilizing system ( also not shown ). there is a low pressure ( e . g ., 40 cm of water ) pop off valve ( 35 ) upstream of the interface . this valve prevents potentially damaging high pressures from occurring in the downstream system ( for example , a patient &# 39 ; s airway ). within the low pressure compartment of the gas / liquid container , liquid condensate will form due to the collision of droplets . this may be removed by means of a pump ( 27 ) through a pipe ( 26 ) and transported back to the liquid reservoir ( 13 ) for reuse . liquid may be introduced into the liquid reservoir ( 13 ) from a feeder ( 14 ). if the liquid level in the reservoir is below that of a level sensor ( 37 ), an automatic switch may be activated , allowing liquid to be fed into the reservoir by gravity from an appropriate container ( not shown in the drawing ). when the liquid level is above the level sensor , the automatic switch will be turned off . gas may be fed into the system through a gas pipe ( 11 ) from a gas reservoir ( 24 ). a regulator ( 25 ) may be included on the gas pipe ( 11 ) to convert the high pressure gas released from the gas tank into a low pressure gas ( for example , 40 cm of water ). a balloon ( 38 ) maybe installed on the gas pipe as a reservoir to prevent negative pressure and an automatic switch ( 34 ) can be used to control whether the one - way valve on the gas pipe ( 8 ) is open . a standard ultrasonic nebulizer may be used to improve the uniformity of the size of the droplets produced by the device discussed above . fig6 is a stylized drawing showing one way in which this can be done . the high pressure compartment is represented in the drawing as ( 30 ) and contains a gas / liquid mixture ( 17 ). the surface of the ultrasonic nebulizer is placed at an orifice ( 20 ) where a high - pressure jet ( 44 ) of mist is released from the high pressure compartment ( 30 ). in order to avoid formation of ice on the surface of the ultrasonic nebulizer ( 45 ), the surface is coated with a hydrophobic material ( 46 ). the nebulizer ( 45 ) and the coat ( 46 ) vibrate at the same frequency ( for example 2 . 4 mhz ) and produce a homogeneous mist ( 47 ) with , for example , a mean droplet diameter of 4 . 7 micrometers . an alternator ( 48 ) controls the vibration frequency of the ultrasonic nebulizer ( 45 ). the high - pressure jet ( 44 ) hits the coating ( 46 ) on the ultrasonic nebulizer at an angle of between 15 and 30 degrees . this minimizes the depth of the liquid layer over the ultrasonic nebulizer , which improves efficiency . this design provides several advantages : high output , as all the liquid released from the ultrasonic nebulizer should be already aerosolized . high efficiency , as the liquid is already in the form of small droplets , thus needing less energy for further nebulization . the ultrasound energy does not have to penetrate a long distance before being used to nebulize the liquid , as only a thin layer of the liquid covers the ultrasonic nebulizer . a simple design , as there is no need to control the depth of the liquid layer over the nebulizer . easy control of the droplet size by changing the nebulizer vibration frequency . the properties of the mist generated using the procedures described above can be more easily controlled than the properties of mists produced by other methods . the mists may be used to deliver medications to a patient &# 39 ; s respiratory system or in a wide variety of non - medical uses , including irrigation , producing mists for extinguishing fires , industrial uses such as painting , and humidification . the most preferred use of the mists is for rapidly changing the body temperature of a patient . the degree to which the patient is cooled or warmed will be determined by clinical considerations on a case - by - case basis . reducing body temperature will be desirable for patients undergoing cardiac surgery or neurosurgery , as a treatment for stroke and to improve neurological outcome after resuscitation from cardiac arrest . mists may be administered at a temperature only slightly below body temperature , e . g ., at about 30 ° c ., or , alternatively , may be administered at near - freezing temperatures . warmed preparations may also be used and should , in general , not exceed a temperature of about 42 ° c . these mists will be desirable for patients suffering from hypothermia . any physiologically acceptable gas and liquid may be used for the creation of a mist for administration to a patient . preferred gases are air and oxygen or a combination of the two . the preferred liquid for the generation of mist is saline . in general , the mist should comprise 90 - 99 . 5 % ( preferably 95 - 99 %) gas by volume , and 0 . 5 - 10 % ( preferably 1 - 5 %) liquid . mists should be continually administered until the desired body temperature is reached as determined using standard methods well known in the art . in general , mists used for these applications should have as small a particle diameter size as possible . all references cited herein are fully incorporated by reference . having now fully described the invention , it will be understood by those of skill in the art that the invention may be performed within a wide and equivalent range of conditions , parameters and the like , without affecting the spirit or scope of the invention or any embodiment thereof .
the present invention is directed to a method and device for generating a mist . mist is created by a sudden drop in the pressure of a gas / liquid mixture . this results in the rapid expansion of the volume of the gas component and the consequent breaking of the liquid into tiny droplets . the method and device allow for the precise control of both the size of the liquid droplets and the density of the mist produced . the mists may be used in a wide variety of applications , including medical procedures in which the body temperature of a patient is rapidly changed and any industrial procedure where a mist is needed .