the particulars shown herein are by way of example and for purposes of illustrative discussion of the embodiments of the present invention only and are presented in the cause of providing what is believed to be the most useful and readily understood description of the principles and conceptual aspects of the present invention . in this regard , no attempt is made to show structural details of the present invention in more detail than is necessary for the fundamental understanding of the present invention , the description taken with the drawings making apparent to those skilled in the art how the several forms of the present invention may be embodied in practice . referring to the drawings , wherein like characters represent like elements , fig1 shows a clip applying device 50 for applying medical tissue - pinching clips 52 a , 52 b to tissue . the clip applying device 50 has a patient - engaging distalmost end 54 with a pair of squeezable jaw members ( jaws ) 56 arranged thereon . an elongated channel member or frame ( also referred to as the spine ) 58 is surrounded by an elongated tube 60 , which elongated tube 60 and elongated channel member 58 are secured at their respective proximalmost ends to the distal end of a generally pistol - like handle grip assembly 62 . the handle grip assembly 62 includes an arcuately movable squeezable trigger 64 that pivots about pivot shaft 64 p . by releasing the squeezed trigger 64 away from a housing portion 66 of the handle grip assembly 62 , a clip 52 a ( shown in fig2 ), 52 b ( shown in fig3 ) is advanced through the distal end of the elongated channel member 58 and into the jaws 56 from an elongated ladder - like clip supply cartridge 68 a ( shown in fig4 ), 68 b ( shown in fig5 ), disposed through the elongated channel 58 . the elongated clip supply cartridge 68 a , 68 b is fed into a receiving slot or port 70 in the proximal end of the handle grip assembly 62 , the receiving slot being in communication with the elongated channel 58 . a rotatable enclosure barrel ( also referred to as a tube ) 72 is rotatably supported within the handle grip assembly 62 . the rotatable enclosure barrel 72 is connected to the proximal end of the elongated channel 58 . the enclosure barrel 72 has an annular distal bearing ( first bearing ) 74 slidably disposed thereon and an annular proximal bearing ( second bearing ) 76 slidably disposed thereon . while the figures show a cylindrical barrel ( i . e ., a round cross - section ), it should be readily appreciable by those skilled in the art that the barrel may have alternative shapes , including but not limited to oval , square and triangular cross sections . the distal bearing 74 has a compression spring 78 arranged against its distalmost surface 80 . the compression spring 78 releases a cinch 86 after the jaws 56 have been closed and a clip 52 a , 52 b has been crimped , and also provides a proximally - directed bias against the distal bearing 74 . the distal bearing 74 has an elongated cinch rod 84 ( shown in fig6 - 9 ) extending distally therefrom . the cinch rod 84 extends through the length of the elongated channel 58 ( and its surrounding protective enclosure tube 60 ). the cinch 86 ( shown in fig1 ) is generally semi - cylindrically - shaped and arranged on the distal end of the cinch rod 84 . the cinch 86 is slidably arranged on the distal end of the elongated channel 58 and is reciprocally slidable in axial direction x to engage the jaws 56 which are squeezably arranged on the distal end of the clip applying device . the each jaw member 56 is located on a respective jaw arm 256 , and the jaws 56 and jaw arms are part of a jaw assembly 156 . the jaw arms 256 are biased outwardly ( i . e ., the jaws 56 are biased open ). distal and proximal movement of the cinch 86 in axial direction x and with respect to the elongated channel 58 effects the respective squeezing closure and biased opening of the jaws 56 at the distal end of the elongated channel 58 . the cinch rod 84 moves in axial direction x to slide the cinch 86 distally and proximally corresponding to the direction of movement of the distal bearing 74 on the distal end of the enclosure barrel 72 . the distal bearing 74 is biased proximally by the compression spring 78 , effecting a proximal motion to the distal bearing 74 . the distal bearing 74 is operatively connected to the trigger 64 by a distal paddle 23 , and the proximal bearing 76 is operatively connected to a proximal paddle 25 , which is in turn connected to the trigger by a trigger linkage 98 . thus , the proximal bearing 76 is biased distally by the compression spring via the trigger linkage 98 . an elongated pusher rod 88 extends adjacent to the lower side of the elongated channel 58 ( as shown , e . g ., in fig1 , 6 - 9 and 37 ). the elongated pusher rod 88 has a proximal end connected to the proximal bearing 76 surrounding the enclosure barrel 72 at the proximal end of the handle grip assembly 62 . the pusher rod 88 is connected to a clip - engaging feeder 90 ( shown in fig2 - 3 ). the feeder 90 is movable in axial direction x in relation to the clip - loaded cartridge 68 a , 68 b disposed within the elongated channel 58 ; however , the pusher rod is disposed below the elongated channel 58 ( shown in fig6 ). proximal motion of the feeder 90 is effected by proximal motion of the proximal bearing 76 around the enclosure barrel 72 within the handle grip assembly 62 . as the trigger 64 is squeezed ( i . e ., as the trigger is moved toward the housing portion 66 and pivoted about pivot shaft 64 p ), the pusher rod 88 distally retracts in the axial direction x due to distal movement of the distal bearing 74 , which distally moves feeder 90 to retrieve a distalmost clip 52 a ′, 52 b ′ of the plurality of clips that are serially loaded in respective clip cartridges 68 a , 68 b , in order to prepare ( upon release of the trigger ) to load the distalmost clip 52 a ′, 52 ′ into guide slots 194 ( shown in fig1 - 11 and 19 ), in the opposed faces of the respective jaws 56 . the term “ plurality ” as used throughout the specification is to be interpreted to mean greater than one and within a number understood by those skilled in the art . the trigger 64 is biased toward the unsqueezed position by the compression spring 78 ( shown in fig1 ). upon release of the trigger 64 , the distal bearing 74 is biased to move proximally , resulting in proximal ( rearward ) movement of the cinch 86 by the proximal movement of the cinch rod 84 , which permits the jaws 56 to bias themselves open , and the feeder 90 ( pushed by the pusher rod 88 ) to push the next available ( distalmost ) clip 52 a ′, 52 b ′ into the guide slots 194 of the respective jaws 56 as the jaws 56 open fully , as the trigger 64 is permitted to open fully ( shown in fig1 ) from the handle 66 portion of the handle grip assembly 62 . release of the trigger 64 ( after the trigger 46 has been initially squeezed towards the handle 66 ) will automatically advance the next available distalmost clip 52 a ′, 52 b ′ within the cartridge 68 a , 68 b . the embodiments disclosed herein are configured to accept more than one type of cartridge ( e . g ., cartridges having different sizes and / or shapes ). it is noted that throughout the specification , the term “ size ” to describe the different clips and / or the cartridges also includes shape as well . in a non - limiting embodiment , the clip applying device 50 of present invention accepts a clip cartridge 68 a containing a series of medium - large sized clips 52 a , and can also accept a clip cartridge 68 b containing a series of large - sized clips 52 b . it should be readily appreciable by those skilled in the art , however , that in alternative embodiments , the present invention may be configured to accept various other types of clip cartridges , including but not limited to small and medium cartridges , medium and medium - large cartridges , and small and large cartridges . additionally , while the figures show the clip applying device 50 being able to work with two types of cartridges , it should be readily appreciable by those skilled in the art , however , that in alternative embodiments more than two types of cartridges may be accepted . referring to fig6 - 9 , when the clip applying device 50 is loaded with a cartridge 68 a , 68 b , there is a predetermined distance da , db between the proximal bearing 76 and distal bearing 74 , this distance being determined by a stop key 13 located in the enclosure barrel 72 . when the clip cartridge 68 b is inserted into the receiving slot or port 70 of the clip applying device 50 , the cartridge is slid along axial direction x until it reaches a stop ( not shown ) and the cartridge can no longer be slid . the stop key 13 is then lowered into a stop keyhole 34 ( shown in fig5 ) of the cartridge 68 b by pivoting action of the stop key ( shown in fig8 - 9 ). when the trigger 64 is released ( i . e ., when the clip applying device 50 is at rest , shown in fig1 ), the proximal bearing 76 and distal bearing 74 move towards each other such that the stop key 13 is sandwiched therebetween to create a distance db between the proximal bearing and distal bearing . the distance db results from the distal bearing 74 contacting a first distal face 13 a of the stop key 13 , and the proximal bearing 76 contacting a first proximal face 13 b of the stop key . when the clip cartridge 68 a is inserted by the user into the receiving slot or port 70 of the clip applying device 50 , the cartridge slides along axial direction x until it reaches a stop and the cartridge can no longer move axially . the clip cartridge 68 a ( shown in fig4 ) does not have a stop keyhole for the lowering of the stop key 13 therein . thus , when the trigger 64 is released ( i . e ., when the clip applying device 50 is at rest ), the proximal bearing 76 and distal bearing 74 move towards each other such that the stop key 13 is sandwiched therebetween to create a distance da between the proximal bearing and distal bearing ( shown in fig6 - 7 ). the distance da results from the distal bearing 74 contacting a second distal face 13 c of the stop key 13 , and the proximal bearing 76 contacting a second proximal face 13 d of the stop key . the distance da is less then the distance db because the proximal bearing 76 and distal bearing 74 are closer to each other in the axial direction x . additionally , due to the configuration of the face surfaces 13 a - d of the stop key , when the cartridge 68 a is inserted into the clip applying device 50 , the proximal bearing 76 and distal bearing are both located more distally than when the cartridge 68 b is inserted into the clip applying device . thus ( as shown in fig2 - 3 ), when the cartridge 68 a is inserted into the clip applying device 50 , the cinch is advanced in the distal direction to narrow the jaws to a width wa , and when the cartridge 68 b is inserted into the clip applying device 50 , the cinch 86 is advanced ( a lesser amount than when the cartridge 68 a is inserted ) in the distal direction to narrow the jaws to a width wb . the width wa is narrower than the width wb because when the cartridge 68 a is inserted into the clip applying device , the cinch 86 is distally advanced a greater amount in the axial direction x than when the cartridge 68 b is inserted into the clip applying device . as described further hereinbelow , each jaw member 56 is increasingly tapered from a proximal point along the axial direction x to a distalward point where a maximum width portion 56 w is located . thus , the more the cinch 86 is advanced distally toward the maximum width portion 56 w , the narrower the width between the jaws . in this way ( shown in fig2 ), the narrower width wa allows the jaws 56 to securely accommodate medium - large clips 52 a in the guide slots 194 . similarly ( shown in fig3 ), when the cartridge 68 b is inserted into the clip applying device 50 , since the cinch 86 is advanced a lesser amount than when the cartridge 68 a is inserted , the jaws are opened wider to width wb to allow the jaws 56 to securely accommodate large clips 52 b in the guide slots 194 , which may have a width larger than smaller clips ( e . g ., medium - large clips 52 a ). further ( as shown in fig2 - 3 ), when the cartridge 68 a is inserted into the clip applying device 50 , the feeder 90 is advanced to the proper position to load the clip 52 a , and when the cartridge 68 b is inserted into the clip applying device 50 , the feeder 90 is advanced ( a lesser amount than when the cartridge 68 a is inserted ) to properly load the larger clip 52 b . in other words , when the cartridge 68 b is inserted , the feeder 90 does not distally advance as much as when the cartridge 68 a is inserted , because the feeder must be further back to accommodate the larger clip 52 b ( shown in fig3 ), which may have a longer length than smaller clips ( e . g ., medium - large clips 52 a ). in the above - described embodiment , the position in the axial direction x of both the cinch 86 and the feeder 90 is determined by the stop key 13 ; however , it is appreciable by those skilled in the art that in alternative embodiments , the position in the axial direction x of only one of the cinch 86 and the feeder 90 may be determined by the stop key , i . e ., the stop key may be differently configured to allow varied displacement between the proximal bearing 76 and distal bearing 74 . for example , when two clip types of different widths but of the same lengths are respectively used in two different cartridge types , the displacement in the axial direction x of only the cinch may be varied depending on which cartridge type is used , because the feeder is displaced by the same amount in either clip type . similarly , when two clip types of different lengths but of the same widths are respectively used in two different cartridge types , the displacement in the axial direction x of only the feeder may be varied depending on which cartridge type is used , because the distance between the jaws does not need to be adjusted . it is noted that in a non - limiting embodiment , either or both cartridges 68 a , 68 b may contain safety keyholes 77 a and 77 b ( shown in fig4 - 5 ) which do not interact with the stop key 13 , but rather accept a safety key 110 , in order to prevent insertion or withdrawal of the clip cartridge 68 a , 68 b unless the trigger 64 is generally fully squeezed rearwardly toward the handle 66 of the handle grip assembly 62 in a manner similar to that disclosed in commonly - assigned u . s . patent publication no . 2003 / 0040759 . it is also noted that in a non - limiting embodiment , the trigger 64 may be squeezed to allow the insertion of the cartridge 68 a , 68 b and / or to crimp a clip 52 a , 52 b ; however , it should be appreciated that in alternative embodiments , other structure may be used ( e . g ., a separate or integral tab , button , lever or switch ), which may be activated to allow the cartridge 68 a , 68 b to be inserted ( and / or to crimp a clip 52 a 52 b ), such that the position in the axial direction x of the proximal bearing 76 or the distal bearing 74 may be determined . the cinch 86 and jaw assembly 156 of the present invention allow full , positive and consistent control of the opening and closing of the jaws 56 in direction z ( shown in fig2 and 10 ), hereinafter referred to as radial or transverse movement , movement in the radial direction or movement in the transverse direction . because the clip applying device 50 is able to accept two different types of clip cartridges 68 a , 68 b , and the jaws 56 thus move radially over a greater distance than other clip appliers , such full , positive and consistent control of the jaws 56 is required . further , limited travel in the axial direction x of a cinch is normally not enough to cover this increased radial travel of the jaws 56 . in other words , there is no single surface of the cinch 86 or jaw assembly 156 to completely and accurately control the opening and closing of the cinch . an embodiment of the present invention includes a cinch 86 that allows for greater radial movement of the jaws 56 by engaging different jaw engagement surfaces 156 a , 156 b , 156 c , 156 d , 156 e , 156 f of each jaw arm 256 . the generally semi - cylindrically - shaped cinch 86 has a pair of control fingers ( or control members ) 30 ( shown in fig1 ) on the underside thereof which engage inner engagement surfaces 156 e and outer engagement surfaces 156 f of the jaw arms . in a non - limiting embodiment , the inner and outer engagement surfaces 156 e , 156 f , as well as the control fingers 30 , may be tapered or angled . fig1 shows the cinch 86 in an intermediate position , where the control fingers 30 are intermediate the respective inner engagement surfaces 156 e and outer engagement surfaces 156 f . in this position ( in a non - limiting embodiment ), medium - large clips 52 a may be loaded and the jaw arms may be at rest ( i . e ., spring forces of the jaw arms are acting neither inwardly nor outwardly in the radial direction z ). when the cinch is moved proximally in the axial direction x from the intermediate position , outer control surfaces 30 e of the control fingers 30 respectively engage the inner engagement surfaces 156 e to widen the gap between the jaws 56 ( e . g ., to a width wb , in order to accommodate cartridge 68 b containing large sized clips 52 b ), while inner control surfaces 30 f of the control fingers are brought out of contact with respective outer engagement surfaces 156 f , as shown in fig1 and 17 . conversely , when the cinch is moved distally from a proximalmost position toward the intermediate position , the outer control surfaces 30 e of the control fingers respectively slide along the inner engagement surfaces 156 e to gradually ( due to the angled configuration ) let the jaw arms 256 bias themselves inward . similarly , when the cinch is moved distally in the axial direction x from the intermediate position , inner control surfaces 30 f of the control fingers 30 respectively engage the inner engagement surfaces 156 e to narrow the gap between the jaws 56 ( e . g ., to a width wa , to accommodate cartridge 68 a containing medium - large sized clips 52 a , or to begin a clip - crimping operation ), while outer control surfaces 30 e of the control fingers are brought out of contact with respective outer engagement surfaces 156 e , as shown in fig1 and 17 . in a non - limiting embodiment , in order to ensure smooth transfer of control throughout the range of movement of the cinch 86 , the control fingers 30 are preferably always in contact with at least one of the inner or outer engagement surfaces 156 e , 156 f ( as shown in fig1 ). fig1 shows the cinch 86 in a fully distal position in which a clip 52 a , 52 b may be fully crimped closed . in a non - limiting embodiment , in order to move the cinch 86 from the fully - distal position along the axial direction x , the cinch includes a generally arcuate central block 32 having opposed ends which respectively engage second inner engagement surfaces 156 d located on an upper surface of each jaw arm 256 ( shown in fig1 and 19 ), which may be tapered or angled in a non - limiting embodiment . the central block 32 ensures accurate and precise transition of the control surfaces of the cinch 86 when the jaws 56 begin to open ( i . e . when the cinch moves proximally along axial direction x ) from the closed jaw position . for example , when the cinch 86 begins to open from the closed jaw position ( shown in fig1 ), a proximal facing surface 32 d of the central block 32 engages the second inner engagement surfaces 156 d commence an opening operation of the jaws . after the cinch 86 moves proximally partway along the axial direction x toward the intermediate position , control of the opening of the jaws 56 is “ handed off ” to the inner control surfaces 30 f of the control fingers 30 , which respectively slide along the outer engagement surfaces 156 f to gradually ( due to the angled configuration ) provide for outward movement of the jaw arms 256 ( in direction z ). although the central block 32 is shown in the figures as being arcuate , it should be understood by those skilled in the art that the central block may take a variety of shapes , including but not limited to , e . g ., a wedge , circle , a v or w shape . in a non - limiting embodiment , the cinch 82 may include a pair of inwardly facing guide walls 34 ( shown in fig2 - 21 ) configured to respectively slidingly engage one or more outer side engagement surfaces 156 a - c ( shown in fig1 and 22 ) of each jaw arm 256 to provide further control of ( e . g ., pitch in the radial direction ) the jaw assembly 156 by the cinch . with such a configuration it may not be necessary for the jaw assembly 156 to remain at rest in the intermediate position . additionally , since the control fingers 30 protrude inwardly , a gap or channel g may be present between the control finger 30 and the ceiling 82 c of the cinch 82 . a portion of each jaw arm 256 may then be sandwiched between a respective control finger 30 and the ceiling 82 c of the cinch 82 , thereby providing control and stability ( by e . g ., preventing dive ) of the jaws in a y - axis direction as the cinch slides in the x - axis direction . in fig2 and 10 , the radial opening and closing direction of the jaws 56 appears to be orthogonal to the axial direction x ( i . e ., it appears to be parallel to the axial direction z ); however , it should be understood by those skilled in the art that orthogonal radial movement of the jaws is neither necessary nor required . as shown in fig1 , in a non - limiting embodiment , the jaw arms 156 may pivot about pivot point p and as such , may result in the radial movement of the jaws being oblique ( i . e ., in a radial oblique direction ) to the axial direction x . it is also noted that the cinch control arrangement of the present invention is not limited to a medical clip applier device . rather , it should be understood by those skilled in the art that the above - described cinch control arrangement of present invention may be used in other clip - applying devices , and may also be used in other devices where a cinch is moved axially to widen and / or narrow a gap between a pair of jaws or other members . as described above , the clip applying device 50 of the present invention is able to accept at least two different types of clip cartridges 68 a , 68 b , and as such , the present invention also provides a cartridge alignment device 36 ( shown in fig2 - 26 ) that can center ( along central axis cx ) clip cartridges 68 a , 68 b within the elongated tube 60 in a width , or transverse direction ( or radial direction ) z of the cartridges . in other words , the alignment device 36 can maintain the loaded cartridges 68 a and 68 b in a central position in relation to the sides ( i . e ., equidistant to the sidewalls of the tube 60 in the radial orthogonal z axis direction ) of the elongated tube 60 ( i . e ., so that a sagittal plane defined by the x - y axis bisecting the cartridges 68 a , 68 b is substantially coplanar with a sagittal plane x - y that bisects the elongated tube . with such an arrangement , the clip cartridge 68 a , 68 b can be centered within the elongated tube and the clip cartridge 68 a , 68 b and the elongated tube , are aligned in the axial direction x ( i . e ., along the central axis cx ). thus , a clip 52 a , 52 b can be accurately loaded in the jaws 56 and accurately crimped thereby . the alignment device 36 has a pair of elongated rails 38 extending in the axial direction x . the rails 38 each have a distal ( first ) region 38 a defining a first channel ca therebetween , a middle ( second ) region 38 b defining a second channel cb therebetween , and a proximal ( third ) region 38 c defining a third channel cc therebetween . each channel ca , cb and cc successively extends in communication and in the axial direction x . in a non - limiting embodiment , the distal channel ca is narrower than the middle channel cb , which in turn is narrower than the proximal channel cc . the alignment device also has a pair of transition areas 38 t ( each located between a respective distal region 38 a and middle region 38 b ) which may be tapered or angled to accurately guide the insertion of cartridge 68 a ( which is inserted along axial direction x , also referred to as an insertion axis direction ) into the distal channel ca , where the cartridge 68 a is securely held and centrally aligned therein in the radial or transverse direction z ( i . e ., cartridge 68 a is sandwiched between both distal regions 38 a ), due to the extending of the distal channel ca in the axial direction x . in situations where the cartridge 68 b is wider in radial direction z than the cartridge 68 a , the cartridge 68 b cannot fit within the distal channel 68 a . rather , the transition area blocks the cartridge 68 b from being inserted in the distal channel 68 a , and also prevents damage to the cartridge 68 b during the insertion process . thus , the cartridge 68 b is securely held and centrally aligned in the channel cb in the radial direction z ( i . e ., the cartridge 68 b is sandwiched between both middle regions 38 b ), due to the extension of the middle channel cb in the axial direction x . the proximal channel cc is configured to hold the elongated channel member 58 ( through which the cartridge 68 a , 68 b is inserted in the insertion axis direction ), which is inserted therein during the manufacturing / assembly process . thus , the elongated channel member 58 is also securely held and centrally aligned in the proximal channel cc in the radial direction z ( i . e ., the elongated channel member 58 is sandwiched between both proximal regions 38 c ), due to the extension of the middle channel cb in the axial direction x . additionally , the alignment device 36 also includes a stop region 36 s which prevents distal displacement in the axial direction x of the elongated channel member 58 . the thickness of a lower portion of the elongated channel member 58 is preferably the same thickness as the lower portion of the stop region , thereby ensuring smooth loading of the cartridges 68 a , 68 b into their respective channels ca , cb . the alignment device 36 may further include an axially - extending cavity 40 configured to accept the insertion and retraction of the clip - engaging feeder 90 when it loads a clip 52 a , 52 b ( i . e ., the cavity 40 can accommodate the feeder 90 therein , between the rails 38 ), and may further include a ramp portion 42 configured to facilitate the sliding and loading of a clip 52 a , 52 b into guide slots 194 of the jaws 56 . the alignment device may also include a middle inclined region 84 , located distally of the cavity 40 and extending in the axial direction x , to assist in the upward distal sliding in the axial direction x of the feeder 90 . further , the alignment device 36 may have an angled or tapered surface 44 at the distal end thereof and / or a semi - cylindrical outer surface 48 , to facilitate the insertion of the alignment device , and therefore the clip - applying device 50 , into the body cavity . an advancement block ( also referred to as a slider ) 12 ( shown in fig2 and 29 - 36 ) is attached between the pusher rod 88 and clip - engaging feeder 90 ( shown in fig2 - 3 and 37 ). the feeder 90 is movable in axial direction x in relation to the clip - loaded cartridge 68 a , 68 b disposed within the elongated channel 58 ; however , the pusher rod is disposed below the elongated channel 58 ( shown in fig6 and 28 ). the slider 12 has a ladder - engaging toggle 14 , which is configured to sequentially engage a series of openings in ladder member 33 a , 33 b ( respectively shown in fig4 - 5 ) slidably arranged within a respective clip cartridge 68 a , 68 b . the ladder member 33 a , 33 b , which is engaged by the toggle 14 of the slider 12 ( the slider being operatively connected to pusher rod 88 as shown in fig3 ) is pushed in the distal direction ( along axial direction x ) to in turn push against the proximalmost or last clip 52 a ″, 52 b ″ in the cartridge 68 a , 68 b , so as to also push distally the next adjacent clip ( s ) 52 a , 52 b within that cartridge 68 a , 68 b . forward ( or distal ) advance of the series of clips 52 a , 52 b loaded within the cartridge 68 is thus effected . as shown in fig2 and 29 - 36 , the ladder - engaging toggle 14 pivots in both directions about a pivot shaft 20 , at least a portion of the pivot shaft generally extending in the orthogonal radial direction z ( i . e ., generally orthogonal to the axial direction x ). thus , the toggle is pivotable about the z axis . as best shown in fig3 - 36 , the pivot shaft 30 may be generally shaped like a u or j , so that the pivot shaft does not slide out of the slider 12 . alternatively , the pivot shaft may have elongated shaft ends , rivets and the like to prevent such sliding out of the slider 12 . in a non - limiting embodiment , the toggle 14 is generally shaped like a right triangle , but it should be readily appreciable by those skilled in the art that the toggle can take any variety of desirable shapes and configurations . the toggle 14 has a ridge 14 a that engages a toggle spring 16 affixed to the slider 12 . the spring 16 may be a leaf spring ( but can be other biasing devices including but not limited to a coil spring or other spring - like members formed , e . g ., of an elastomeric material ), which engages the ridge 14 a to bias the toggle in an upright ( second ) position , shown in fig3 - 31 and 36 . in a non - limiting embodiment and as shown in fig2 , the channel is generally u - shaped , and as described above , the slider 12 proximally and distally slides below and adjacent to the channel 58 in the axial direction x . the channel 58 additionally includes a toggle aperture 58 c 1 in the bottom portion thereof , through which a portion of the toggle 14 is inserted , when the toggle is in the upright position . operation of the clip advancement arrangement according to an embodiment of the present invention will now be described . when the trigger 64 is squeezed , the slider 12 is moved proximally in the axial direction x ( since the slider is operably connected to the pusher rod 88 , which is in turn connected to the proximal bearing 76 ). as the slider 12 is moved proximally , an edge - engaging face 14 b of the toggle 14 engages an edge 58 e of the channel 58 , such that the channel edge 58 e ( which generally extends in the z axis direction ) pushes the toggle 14 to rotate in a first direction ( e . g ., counterclockwise when viewing fig3 - 32 ) to a lowered ( first ) position and against the biasing force of the toggle spring 16 , shown in fig3 - 32 . in the first position , the toggle 14 slides in the axial direction x and below the channel 58 , with at least a portion of the edge - engaging face 14 b contacting the underside of the channel 58 . it is noted that the channel edge 58 e may be angled or tapered to increase the surface area thereof , thereby ensuring smooth and precise pivoting action of the toggle 14 . when the trigger 64 is released , the slider 12 begins to distally move in the axial direction x . the edge - engaging face 14 b contacts the underside of the channel 58 until the toggle 14 reaches the toggle aperture 58 c 1 , at which point the edge - engaging face 14 b contacts the channel edge 58 e and allows the toggle spring 16 to urge the toggle into the upright position ( shown in fig3 - 31 and 36 ) and between rungs 33 a r , 33 b r of the ladder member 33 a , 33 b , the rungs having rung gaps 33 a g , 33 b g therebetween . thus , the toggle 14 rotates in a second direction ( clockwise when viewing fig2 - 30 ). pivoting of the toggle 14 in the second direction is stopped when a heel portion 14 d engages a stop portion 18 located on the slider 12 . once in the upright position , the toggle 14 continues to move distally through the toggle aperture 58 c 1 ( and within a rung gap 33 a g , 33 b g ) in the axial direction x such that a pushing face 14 c contacts a rear ( proximal ) side of a rung 33 a r , 33 b r of the ladder member 33 a , 33 b . thus , the toggle 14 pushes the ladder member 33 a , 33 b in the distal direction ( along axial direction x ) to in turn push against the proximalmost or last clip 52 a ″, 52 b ″ in the cartridge 68 a , 68 b to also push distally the next adjacent clip ( s ) 52 a , 52 b . it is noted that while the rungs 33 a r , 33 b r of the figures extend in the z axis direction , those skilled in the art will readily appreciate that the rungs could be differently configured in alternative embodiments , including but not limited to , e . g ., angled and arcuate . the above process may be repeated by continually squeezing and releasing the trigger 64 , which in turn continually distally advances the ladder member 33 a , 33 b to distally push clips 52 a and 52 b , until the last clip 52 a ″, 52 b ″ is loaded into and applied by the jaws 56 . it is noted that while many of the figures show the clip advancement arrangement of the present invention being used in a clip applying device 50 that can accept more than one type of clip supply cartridge 68 a , 68 b , it should be readily understood by those skilled in the art that the clip advancement arrangement of present invention may be used in a clip applying device that can accept only a single type of cartridge , or alternatively , may be used in a clip applying device having clips pre - installed therein . fig3 shows a trigger lockout arrangement 11 . as described above , the slider 12 is attached between the pusher rod 88 and clip - engaging feeder 90 . the trigger lockout arrangement 11 serves to lock movement of the trigger 64 when the last clip 52 a ″, 52 b ″ of the cartridge 68 a , 68 b has been applied by the jaws 56 , thereby reducing the likelihood of tissue damage by squeezing jaws without a staple therein , and alerting the surgeon that additional clips are required . also as discussed above , when the trigger 64 is squeezed , the slider 12 proximally moves in the axial direction x , and when the trigger is released , the slider moves in the axial direction x such that the toggle 14 distally advances the ladder member 33 a , 33 b by one clip and such that the feeder 90 loads the distalmost clip 52 a ′, 52 b ′ between the jaws 56 . the channel member 58 also includes a block 91 affixed to the underside of the channel member via a flexible rod 92 , and additionally has a block aperture 58 c 2 , located above the block 91 in the y - axis direction , for accepting insertion of at least a portion of the block 91 therein . at rest , the flexible rod 92 is biased to generally extend in the axial direction x . the slider 12 also has a tooth 93 that contacts the block 91 when the slider is proximally or distally moved in the axial direction x . while the block 91 is shown as being cubical in arrangement , it should be understood by those skilled in the art that in alternative embodiments the block can take a variety of shapes , including but not limited to , e . g ., a trapezoid , frustum or ovoid . specifically , as shown in fig3 , when the trigger 64 is squeezed and the slider 12 moves proximally in the axial direction x ( to approach the block 91 from the front , shown in fig3 - 38 ), a rear surface 93 a of the tooth 93 engages a front surface 91 a of the block 91 to move the block in radial direction z while the slider continues to move proximally . the rear surface 93 a of the tooth 93 is angled to facilitate movement of the block 91 in the radial direction z . once the slider 12 passes the block 91 , the block returns to its original rest position due to the biasing action of the rod 92 . when the trigger 64 is released , the slider 12 begins to move distally in the axial direction x and approaches the block 91 from the rear ( shown in fig3 ). if a cartridge 68 a , 68 b having a plurality of clips 52 a , 52 b has been loaded into the clip applier 50 , the slider moves distally such that a front surface 93 b ( best shown in fig3 ) of the tooth 93 engages a rear surface 91 b of the block 91 to push the block upward in the y - axis direction ( i . e ., into the page of fig3 ). specifically , the upward movement of the block 91 causes a portion of the block to pass through the block aperture 58 c 2 of the channel 58 and be inserted between the rungs 33 a r , 33 b r of the ladder member 33 a , 33 b ( i . e ., the portion of the block is inserted into a rung gap 33 a g , 33 b g ), thereby creating clearance for the tooth 93 to pass over the block 91 as the slider continues to move in the distal direction . once the tooth 93 has passed over the block 91 , the rod 92 urges the block downwardly , since the rod 92 is biased in the axial direction x and to keep the block out of the ladder gap 33 a g , 33 b g . to facilitate precise movement of the block 91 in the y - axis direction , the front surface 93 b of the tooth 93 and / or the rear surface 91 b of the block 91 may be angled . additionally , one or more bands 95 to slidably secure the slider 12 against the underside of the channel 58 may be provided , thereby securing the slider against movement in the y - axis direction , when the slider moves in the axial direction x . the presence of the block 91 between the rungs 33 a r , 33 b r of the ladder member 33 a , 33 b does not interfere with the distal movement of the ladder member by the toggle , since these two operations are out of phase , i . e ., during distal movement of the slider 12 , the toggle 14 does not engage a rung 33 a r , 33 b r until after the tooth 93 has passed over the block 91 and the block has withdrawn from the ladder gap 33 a g , 33 b g . as described above , the slider may be continually moved proximally and distally by respective continual squeezing and releasing of the trigger 64 , until the last clip 52 a ″, 52 b ″ is loaded into and applied by the jaws 56 . while the last clip 52 a ″, 52 b ″ is being loaded into the jaws 56 by the feeder 90 ( and thus no more clips 52 a , 52 b are serially loaded within the cartridge 68 a , 68 b ), the toggle 14 engages the rung 33 a r , 33 b r , thereby advancing the ladder member 33 a , 33 b a final time and exposing a solid surface 96 of the ladder member beneath the block aperture 58 c 2 ( i . e ., there is no longer a ladder gap 33 a g , 33 b g beneath the block 91 ). the clip applying device 50 is now ready for one final clip crimping process . during the final clip crimping process , the trigger 64 is squeezed to proximally move the slider 12 ( and to thereby bring the tooth 91 thereof behind the block , as described above ) and to distally move the cinch 86 to crimp the last clip 52 a ″, 52 b ″. as shown in fig4 , when the trigger 64 is released after the last clip 52 a ″, 52 b ″ has been crimped , the compression spring 78 urges the trigger toward the open position , which ( as described above ) moves the slider 12 distally so that the tooth 93 engages the block 91 . however , the solid surface 96 of the ladder member 33 a , 33 b prevents displacement of the block 91 by the tooth 93 in the y - axis direction ( since there is no ladder gap 33 a g , 33 b g for the block to enter . thus , the tooth 93 abuts against the block and is prevented from distally moving in the axial direction x , thereby locking the trigger in the closed position and alerting the surgeon that the last clip 52 a ″, 52 b ″ has been applied . as noted above , the bands 95 prevent the slider ( and thereby the tooth 93 ) from being displaced in the y - axis direction so that the tooth does not “ leap over ” the block 91 , when the slider moves in the axial direction x . it is noted , however , that the trigger 64 is permitted to be slightly unsqueezed so that the last clip 52 a ″, 52 b ″ and any tissue can be released from the jaws 56 . once the cartridge 68 a , 68 b has been removed from the clip applying device 50 , the trigger 64 is free to again move to the unsqueezed position , since the solid surface 96 is no longer present . an embodiment of the present invention uses cartridges 68 a , 68 b having twenty clips 52 a , 52 b , however , it should be understood by those skilled in the art that the present invention may use cartridges having fewer or greater than twenty clips . additionally , while an embodiment of the trigger lockout arrangement 11 of the present invention locks the trigger 64 after all of the clips 52 a , 52 b have been applied , it should be understood by those skilled in the art that the trigger lockout arrangement may lock the trigger when one or more clips 52 a , 52 b remains in the cartridge 68 a , 68 b or the clip applying device 50 . it is noted that while many of the figures show the trigger lockout arrangement of the present invention being used in a clip applying device 50 that can accept more than one type of clip supply cartridge 68 a , 68 b , it should be readily understood by those skilled in the art that the trigger lockout arrangement of present invention may be used in a clip applying device that can accept only a single type of cartridge , or alternatively , may be used in a clip applying device having clips pre - installed therein . another feature of an embodiment of the present invention includes a system for indicating to the surgeon when the clip 52 a , 52 b has been partially crimped ( shown in fig4 ) and / or when the clip 52 a , 52 b has been generally fully crimped ( shown in fig4 ). fig4 shows an uncrimped clip . during surgery , a surgeon may want to apply a clip 52 a , 52 b , yet still leave a gap between the legs of the clip to allow passage of a blood vessel therethrough , thereby allowing blood to flow through the vessel unobstructed . when a surgeon partially squeezes the trigger 64 , the jaws 56 are only partially closed and the clip 52 a , 52 b may thus be applied in a partially crimped configuration . this partially - squeezed position is referred to as the cholangio zone . it is thus desirable to alert the surgeon ( visually , audibly and / or tactilely ) as to when the clip applying device 50 is in the cholangio zone ( shown in fig1 and 44 ). it is further desirable to alert the surgeon ( visually , audibly and / or tactilely ) as to when the clip applying device is in fully squeezed position ( shown in fig4 ). the clip applying device 50 may include a visual slider 102 ( housed within the handle grip assembly 62 ) which slides along an indicator path by way of indicator shaft 104 in an inclined direction with respect to the longitudinal axis x , although it should be understood by those skilled in the art that the indicator shaft 104 may be parallel or declined with respect to longitudinal axis x in alternative embodiments . the visual slider is biased in the general distal direction by a shaft spring 106 which may be disposed about the proximal end of the indicator shaft . alternatively , the shaft spring 106 may be disposed at the distal end of the indicator shaft 104 to “ pull ” the visual slider toward the distal end of the grip assembly 62 . the visual slider 102 includes three indicator regions 102 a , 102 b , 102 c , each having different indicia for indicating the position of the trigger , for example , the color , pattern or wording on each region may be different . each region 102 a , 102 b , 102 c is alternatively visible through a window 111 located in the top of the grip assembly . as a non limiting example , indicator region 102 a ( indicating the open trigger position ) may be green , indicator region 102 b ( indicating the cholangio zone ) may be yellow , and indicator region 102 c ( indicating the generally fully - squeezed position ) may be red . alternatively , each indicator region 102 a , 102 b , 102 c may show , e . g ., different wording ( e . g ., “ open ,” “ partial ,” “ closed ”), a different symbol , or a different pattern . in the unsqueezed position ( shown in fig1 ), a first abutment surface 102 d of the visual slider 102 abuts against a first end 112 a of a pivotable trip switch 112 to maintain the visual slider in its distalmost position ( against the distal biasing force of the shaft spring 106 ), and indicator region 102 a is displayed through the window 110 . the trip switch 112 has a trip switch spring 114 which is affixed to the grip assembly 62 to bias the trip switch to pivot in the counterclockwise direction ( when viewed in fig1 ). additionally , a second end 112 b of the trip switch 112 engages an outer surface of the distal bearing to prevent further counterclockwise pivoting of the trip switch . when the trigger 64 is squeezed toward the cholangio zone ( and the distal bearing begins to move distally along axial direction x ), the visual slider 102 remains in position ( due to the continued engagement of the first abutment surface 102 d with the first end 112 a of the trip switch 112 ) until an angled distal surface of a distal bearing ring 108 engages the second end 112 b of the trip switch to pivot the trip switch clockwise ( when viewed in fig1 ), which disengages the first abutment surface 102 d from the first end 112 a of the trip switch 112 , thereby allowing the shaft spring 106 to proximally urge the visual slider 102 . the visual slider is proximally urged until the first end 112 a of the trip switch 112 engages a second abutment surface 102 d of the visual slider 102 to stop proximal movement of the visual slider and exposing the indicator region 102 b through the window 111 ( indicating the cholangio zone to the surgeon ), as shown in fig1 and 44 . when the trigger is squeezed from the cholangio zone to the generally fully squeezed position ( and thus the distal bearing continues to move distally to cause the jaws 56 to generally fully crimp the clip 52 a , 52 b ), the outer circumference of the distal bearing ring 108 further engages the second end 112 b of the trip switch 112 to further pivot the trip switch clockwise , which disengages the second abutment surface 102 d from the first end 112 a of the trip switch 112 , thereby allowing the shaft spring 106 to further proximally urge the visual slider 102 until the slider reaches its limit of proximal travel along the indicator shaft 104 , thereby exposing the indicator region 102 c through the window 111 ( indicating the generally fully squeezed position to the surgeon ), as shown in fig4 . when the trigger 64 is released ( and the distal bearing begins to move proximally due to the biasing force of the compression spring 78 ), a proximal face of the distal bearing ring 108 engages an indicator finger 102 d to proximally move the visual slider 102 so that the first abutment surface 102 d of the visual slider 102 again abuts against a first end 112 a of the trip switch 112 to reset the visual slider in its distalmost position ( thereby again exposing the indicator region 102 a through the window 111 ), as shown in fig1 . it is noted that , in alternative embodiments , one skilled in the art would readily appreciate that the present invention may be provided with only one indicator region 120 a , 120 b , 120 c , only two indicator regions 120 a , 120 b , 120 c ( rather then three as shown in the figures ), or more than three indicator regions , to indicate any combination of ( a ) that the clip - applying device 50 is unsqueezed , ( b ) that the clip applying device is in the cholangio or other mid - squeeze zone , and ( c ) that the clip applying device is generally fully squeezed . the clip applying device 50 of the present invention may also include an audible and / or tactile indicating arrangement . specifically , in the event the surgeon is too focused on the surgery at hand to look at the viewing window 111 , the indicating arrangement may audibly and / or tactilely indicate to the surgeon when the clip applying device is in the cholangio zone and / or when the trigger is generally fully squeezed . additionally , the tactile indicating arrangement of the present invention may assist the surgeon in the event that the surgeon is hearing - impaired . as shown in fig1 and 45 , an upper ( first ) ratchet 120 and a lower ( second ) ratchet 122 are affixed to and move with the trigger 64 , which pivots about the trigger pivot shaft 64 p . additionally , an upper ( first ) pawl 124 and a lower ( second ) pawl 126 are pivotably affixed about a proximal paddle shaft 25 p , about which the proximal paddle 25 is also affixed . additionally , the upper pawl 124 is biased to pivot counterclockwise ( when viewed in fig1 ) by an upper spring 128 , and lower pawl 126 is biased to pivot counterclockwise by a lower spring 130 , the upper spring having a stronger spring force than the lower spring . when the trigger is squeezed from the unsqueezed position toward the cholangio zone , lower spring 130 biases the lower pawl 126 to engage the lower ratchet 122 to create a ratcheting sound as the trigger is squeezed toward the cholangio zone and the upper and lower ratchets pivot counterclockwise about trigger pivot 64 p ( when viewed in fig1 ), while indicator region 102 a is displayed in the window 111 . once the cholangio zone is entered ( and at substantially the same time the window 111 displays indicator region 102 b ), the upper ratchet 120 and lower ratchet 122 continue to pivot counterclockwise so that the upper ratchet engages the upper pawl 124 . specifically , when the cholangio zone is entered , the upper pawl 124 ( due to the biasing force of the upper spring 128 ) engages the first tooth of the upper ratchet 120 to enter a first channel ( cholangio channel ) 120 a of the upper ratchet to emit a distinct sound and transmit a distinct tactile sensation . the sound and feel of the upper pawl 124 entering the first channel 120 a is significantly different than the sound and feel of ratcheting of the lower pawl 126 ratcheting with the lower ratchet 122 , due to the spring force of the upper spring being greater than that of the lower spring . additionally or alternatively , differing the dimensions and / or materials between the upper ratchet 120 and the lower ratchet 122 and / or differing the dimensions and / or materials between the upper pawl 124 and the lower pawl 126 may contribute to the differing sounds and feels when the trigger 64 is squeezed . when the trigger 64 moves from the cholangio zone to the generally fully squeezed position ( and at substantially the same time the window 111 displays indicator region 102 c ), the upper ratchet 120 and lower ratchet 122 continue to pivot counterclockwise such that the upper pawl moves from the cholangio channel 120 a to a generally fully squeezed channel 120 b , to emit the distinct sound and transmit the distinct tactile sensation . it is noted that the two distinct sounds and sensations ( i . e ., of the upper pawl 124 engaging the upper ratchet 120 ) can be made different by differing the dimensions and / or material of the cholangio channel 120 a and the generally fully squeezed channel 120 b . it is further noted that in alternative embodiments , the generally fully squeezed channel 120 b may be eliminated , thereby alerting the surgeon only to when the clip applying device 50 is in the cholangio zone . when the trigger 64 is released , the trigger moves to the unsqueezed position to disengage the upper pawl 124 from the upper ratchet 120 , thereby resetting the clip applying device 50 . the upper ratchet 120 / upper pawl 124 and the lower ratchet 122 / lower pawl 126 lie in different x - y planes ( different sagittal planes ) so that the upper ratchet does not ever engage the lower pawl and so that the lower ratchet does not ever engage the upper pawl . it is noted that while many of the figures show the indicating arrangement of the present invention being used in a clip applying device 50 that can accept more than one type of clip supply cartridge 68 a , 68 b , it should be readily understood by those skilled in the art that the indicating arrangement of present invention may be used in a clip applying device that can accept only a single type of cartridge , or alternatively , may be used in a clip applying device having clips pre - installed therein . it is further noted that the foregoing examples have been provided merely for the purpose of explanation and are in no way to be construed as limiting of the present invention . while the present invention has been described with reference to a preferred embodiment , it is understood that the words which have been used herein are words of description and illustration , rather than words of limitation . changes may be made , within the purview of the appended claims , as presently stated and as amended , without departing from the scope and spirit of the present invention in its aspects . although the present invention has been described herein with reference to particular means , materials and embodiments , the present invention is not intended to be limited to the particulars disclosed herein ; rather , the present invention extends to all functionally equivalent structures , methods and uses , such as are within the scope of the appended claims .
an alignment device for an apparatus . the apparatus is configured to selectively receive a first implement having a first width and a second implement having a second width , the first and second widths extending in a transverse direction generally orthogonal to an insertion axis direction of the first and second implements , the device comprising a pair of generally parallel spaced - apart elongated rails defining at least two channels , the at least two channels comprising a first channel having a first channel width , and a second channel having a second channel width , the first and second channel widths being different , the first channel being configured to centrally hold the first implement in the transverse direction , and the second channel being configured centrally hold the second implement in the transverse direction .