by way of example , the following description of the invention relates to its application as a glucose monitor . it should be understood that this is merely one application among an extensive list of applications of which the invention is capable . referring first to fig1 , there is shown a first embodiment of the present invention , adapted for glucose determination / monitoring , illustrated by a wrist watch or wristlet comprising three types of sensors : pulse - wave sensors 6 a and 6 b , biocompatible electrodes 7 , and additional biocompatible electrodes 8 a and 8 b for detecting perspiration and estimating the acidity thereof . the device comprises the following electronics : a keyboard 1 , a body 2 with a display 3 and an electronic block 4 . the keyboard 1 is supplied with a connector 5 to allow connection of a programmed cartridge , for example a home computer , cellular phone , palm - sized electronic notebook , etc ( not shown ). the body 2 incorporates the pulse - wave sensors 6 a and 6 b , biocompatible electrodes 7 , and additional biocompatible electrodes 8 a and 8 b . electronic block 4 is supplied with an antenna 9 and a connector 10 for transferring data and / or an alarm signal through an external transmission - connection unit ( not shown ), ( e . g . telephone line , fax , the internet ) for sending such data to a physician . the device also includes two thermometers 11 a and 11 b for measuring the patient &# 39 ; s skin and the surrounding temperature , respectively , and a 3 - dimensional accelerometer 12 for measuring motion intensity or physical activity of the hand ( not seen ). fig2 is a block diagram of the components of the device including the operative connections between those components . the two pulse - wave sensors 6 a and 6 b ( pws 1 and pws 2 ), which are connected to a microprocessor ( mp 6 ). three electrodes 7 ( el_ 1 , el_ 2 and el_ 3 ), where electrodes el_ 1 , el_ 2 are electrochemically connected to electrode el_ 3 , which is a reference electrode ( not seen in fig1 as it is inside the electronic block 4 ). the three electrodes 7 ( el_ 1 , el_ 2 and el_ 3 ) are connected to three voltmeters v 2 , v 3 and v 4 , respectively . in order to measure dc and ac voltages it is necessary to use the two separate voltmeters . therefore the signal from the el_ 1 goes to v 1 to measure acidity , to v 2 to measure dc and to v 3 to measure ac . the two perspiration measuring electrodes 8 a and 8 b ( adel_ 1 and adel_ 2 ), which are each connected with a voltmeter ( v 1 , v 2 ) [ reference #&# 39 ; s ? ], respectively ; the 3 - dimensional accelerometer 12 ( acc ). two thermometers 11 a and 11 b ( t - 1 and t - 2 ) for measuring skin and surrounding temperature , respectively . four microprocessors ( mp 1 , mp 2 , mp 3 , mp 4 ); and the programmed microprocessor mp 6 connected to the keyboard 1 ; and a processor , mp 5 , with memory m connected thereto ; and having a charge - connector unit and alarm system . note , the voltmeters and microprocessors referred to herein are not seen in fig1 and so are not given reference numerals ( merely labels as seen in fig2 ), however , they are located within the electronic block 4 . the microprocessor mp 1 is connected with pws 1 and it analyzes pulse - wave spectral characteristics using a standard mathematical software program package ( e . g . matlab or other software ). the microprocessor mp 2 is connected to pws 1 , pws 2 and a timer / clock , and it measures a pulse wave propagation velocity and heart rate . the microprocessor mp 4 is connected to pws 2 and it analyzes a pulse wave spectrum , for example using matlab . the above microprocessors mp 1 , mp 2 and mp 4 are connected with a programmed microprocessor mp 5 having a display . the potential difference between electrodes 8 a and 8 b ( adel - 1 and adel - 2 ) is proportional to the perspiration &# 39 ; s acidity . with reference to fig3 , the principles of pulse wave measurements use the following principles : 1 . the rate of movement of the blood can be estimated by the rate of pulse wave propagation between sensors 6 a and 6 b . 2 . the blood flow is proportional to the cross - section of arteries and the velocity of the blood . 3 . blood viscosity affects the shape of the pulse waves , the rate of their propagation and the pulse wave spectrum . the following data are supplied to the programmed microprocessors from the various sensors : for calibration purposes , the first data are compared in the programmed microprocessor mp 5 with parameters ( i . e . glucose level , blood pressure , heart rate , etc .) that were recorded in the processor &# 39 ; s memory m during an oral glucose tolerance test ( ogtt ) and / or during an electrocardiogram ( ecg ) stress test . the results of such a calibration are input into an individual “ mathematical model ” resulting from an individual calibration with neural network software . similar neural network software is used to estimate the following important parameters : the programmed microprocessor mp 5 displays selected parameters on the display 3 . it is connected with a processor p that can produce an alarm if selected parameters are beyond predetermined limits , which depend on the rate of change of the parameters . the alarm ( and parameters ) may be transmitted through a cellular telephone or other means of communication . all of the parameters are periodically recorded in the memory m in case any deviations , for example , they may be transmitted daily into the computer of a physician , medical center , clinic , etc , through a separate charge - connection unit . preliminary examination of the other components of the device consisted of checking pulse - wave and bio - electricity diagnostics . the above - described theoretical basis of such diagnostics is explained with reference to fig4 - 6 . data for fig4 and 5 were generated from the michaelis - menten equation and the data for fig6 were generated from the lipman equation and electro - capillary curves . the change of the rate of cellular glucose absorption as a function of the blood glucose level at a range of insulin levels ( picomoles / ml ) is shown in fig4 . the rate of glucose absorption depends on glucose and insulin blood level . as seen , the maximal rate of glucose absorption is typically in a bgl range of 65 to 115 mg / dl , which corresponds to the maximal stability of the glucose level and more particularly to the maximal motion force and rate of return to equilibrium ( as seen in fig5 .). the dominant parameter of any living system is metabolism , which includes in particular the equilibrium between carbohydrate metabolism and oxygen / carbon dioxide use and production . fig6 shows the function of gibbs energy of healthy cells ( indicated by diamond symbols ) and cancer cells ( indicated by square symbols ). the relative gibbs energy is relative to the average gibbs energy of the cells ; and the relative intensity of metabolism is relative to the 50 % level of the normal basic metabolism value . metabolism measurements , which are measurable using the device of the present invention , can provide estimation of cellular gibbs energy and thus can provide important information in the treatment of cancer . thus gibbs energy is dependent on the relative intensity of the metabolism . it shows that in the condition of both a metabolism that is too low or too high , the gibbs energy of cancer cells is lower than that of healthy cells . under this condition the rate of cancer cell division may be much higher than in healthy cells . furthermore , the separation between the curves in fig6 shows that there is a gibbs energy difference between cancer and healthy cells which allows the estimation of polymorphism of the cancer cells as the tendency for polymorphism is proportional to the difference in the gibbs energy between the cancer cells and the healthy cells . cancer polymorphism itself is a very important property of the cancer cells which directly affects treatment protocol decisions and the potential effectiveness of cancer treatment . experiments and measurements were made during oral glucose tolerance tests ( ogtt ), which included a blood glucose level measurement by a standard device “ accu - chek ” [ roche diagnostics , mannhelm , germany ]. in parallel , analysis of pulse waves and bio - potentials were performed using the device of the present invention . pulse waves were measured by piezo - electric transducers and microphones in parallel with electrical signals during the measurements . these signals produced from the above measurements were recorded in a computer by standard analog - to - digital protocol and were analyzed by standard mathematical programs ( e . g . “ matlab ”). pulse - wave measurements results obtained by the present device are shown in fig7 ( raw data ), fig8 ( filtered data ) and fig9 ( raw data after fourier transform analysis ). the characteristic forms of the recorded pulse waves using the pulse wave sensors 6 a and 6 b are shown in fig7 at three blood glucose levels ( 130 , 200 and 260 mg / dl ). upon inspection of the curves of fig7 - 9 , it is obvious that the form of the pulse wave and its spectral characteristics changes from bgls of 130 to 260 mg / dl . for example , the downward sloping portions of the curves in fig8 are much less smooth as the bgl increases . therefore , such measurements can be correlated with bgl and thus bgl can be determined via those measurements consistent with the above - mentioned theory and by use of the device of the present invention . with reference to fig9 , it can also be observed that as the bgl increases , there are more high frequency components ( peaks p 1 , p 2 , p 3 , p 4 and p 5 ). again , such results can be used to form a correlation between the pulse - wave measurements and the bgl so that using the device of the present invention , bgl can be conveniently , continuously and non - invasively obtained . in all the experiments described herein , wherein a dc voltage was recorded , a standard agcl reference electrode was used as the reference electrode for the dc voltage measurements . fig1 and 11 show results of simultaneously recorded pulse - wave and bio - potential measurements obtained by the present device ( particularly by pulse - wave sensors 6 a and 6 b ; and electrodes 7 ) and their processing at different bgls , for a diabetic patient ( patient a ) and non - diabetic patient ( patient b ), respectively . it can be seen from these graphs that with the change of the blood glucose level there is change in the spectral characteristics of the pulse waves and voltage measurements . such change is a biological response of a patient to intolerant bgls ( i . e . above 120 mg / dl ). the parameters of these characteristics analyzed by neural network algorithms allow transforming all these multi - parametric dynamical parametrical changes into blood glucose level estimation . thus , the two afore - mentioned experiments indicate that an at least semi - quantitative model can be achieved and used as the basis of the present invention , using measurements of the device of the present invention . fig1 shows the results of a further experiment involving two female volunteers ( volunteer am , aged 63 and volunteer lg , aged 56 ). the volunteers were connected to the device ( particularly electrodes 7 ), in the supine position to avoid uncontrolled movement . during the measurements they were asked to recall different situations from life , including : ( a ) thinking about pregnancy , ( b ) thinking about another person , ( c ) meditation and ( d ) playing with grandchildren . the time at which these thoughts were suggested are shown by arrows on the graphs of fig1 . it can be seen that typically after a brief delay of a few seconds , there is a clear change in the voltage characteristics . such change shows that the voltage measurements ( dc and low frequency ac together with high frequency ac ) are capable of indicating a response to various psycho - emotional stimuli . such measurements therefore have potential applications in lie detector machines and to psycho - immune measurements . fig1 shows the results of different voltage measurements , produced by the electrodes 7 of the device . a device was worn on each of all four limbs and corresponding dc and low and high frequency ac voltage changes were measured during heating of the left leg by an assistant ( at about 65 seconds into the experiment ); and later ( at about 180 seconds into the experiment ) with the volunteer heating his own hands using thought / imagination . the perturbations seen in curves indicate that the device is capable of sensing metabolism and blood flow change in the limbs . thus , the device can be used as a bio - feedback system and for diagnostics . furthermore , the experimental results support a recently developed theory that there is a coordinated interconnection between the limbs . this in itself has an enormous importance for the diagnostics and treatment of limbs . fig1 is a graph showing experimental data generated by the present invention for a diagnostics of a local metabolism disorder . here the device was worn on a portion of a 53 year old male patient having diseased skin with an affected metabolism . the graph shows dynamic voltage change during a bio - resonance electromagnetic treatment . for the first three minutes of the measurements , the patient was working by himself , i . e . using the device as a biofeedback system . at three minutes into the experiment , the patient fell asleep and an electromagnetic resonance treatment began wherein different resonance signals were used . the change in voltage response seen in the curve of fig1 , at three minutes into the experiment when the resonance treatment began , validates the sensitivity of the electrode measurements to a change in local metabolism caused by the treatment . the device further monitored the patient &# 39 ; s metabolism during continuation of the treatment , which was suspended temporarily between 28 - 31 minutes and after 39 minutes . again , the electrodes measure changes in the patient &# 39 ; s local metabolism as seen in the response change shown in fig1 at those times . fig1 graphically shows experimental data generated by the present invention as a pharmaco - dynamics and pharmaco - kinetics tracking system . during this experiment a 64 year - old male volunteer , took a nutrient supplement and the electrodes 7 of the device were placed on his body at locations whereat the supplement was expected to act upon . there is a clear affect in the dynamic voltage , in particular a 50 mv decrease , as a result of the supplement intake . this indicates that the device can be used to track physiological changes in the body as a result of drug / supplement / food intake and thus it has application in pharmaco - dynamics , drug / supplement development , improvement of treatment protocols , diet programs and so on . in fig1 there is shown an embodiment of the device in which a pad 14 comprises an array of electrodes 8 ( and / or sensors 6 , or combination thereof ) arranged on it . in such an arrangement , voltage measurements can be made between electrodes 8 and such a pad 14 can be conveniently disposed at virtually any location on the surface of a biological being . the pad 14 is convenient for use in performing organ metabolic measurements , for example . for clarity , a summary of the particular electrodes / sensors / meters required for different embodiments of the device of the present invention is shown in the table below . required sensors for particular embodiments of the device sensors basic building pulse wave acoustic device block ** sensors sensors thermosensor accelerometer glucose monitor 1 no * no * 1 1 nervous system 1 no * no * no * no * monitor wireless 5 no * no * no * no * ecg local metabolism at least 2 2 no * at least 2 no * monitor limb metabolism 4 8 4 4 4 monitor psychological at least 4 8 4 4 no * detector , lie detector pharmacokinetic ; at least 4 8 at least 4 at least 4 at least 4 pharmacodynamic no * = not required in the most simplistic embodiments of the device , however could be required in more complex embodiments . ** = two spaced apart electrodes at least one of which is in contact with the biological being for providing a bio - potential measurement including a low frequency ac voltage and / or a dc voltage in which one of the two electrodes is a reference electrode providing a reference for the dc voltage . it is important to mention that the implementation of the device being a bb as an ecg provides a compact , user friendly wireless ecg device . the fact that measurements are accomplished by an electrode with reference to a reference electrode allows voltage measurement without connecting an electrical loop through the biological being itself . thus present device and method allows monitoring of a patient &# 39 ; s physiological ( health / illness ) condition by measurement , recording and analysis of the patient &# 39 ; s functional physiological profile . it is very important to note that some of the above - mentioned parameters can be measured using merely dc voltage and / or low frequency ac voltage and do not necessarily need both .
device and method for measuring physiological parameters of a biological being comprising : at least two spaced apart electrodes at least one of which is in contact with - the being for providing a bio - potential measurement including a low frequency ac voltage and / or a dc voltage wherein one of the electrodes is a reference electrode providing a reference for the dc voltage , the low frequency ac voltage and / or dc voltage measurement used to determine the physiological parameters . the device can be built in many forms ; can measure physiological parameters including those related to diabetes , cardiovascular , organ , tissue , brain and neural function , local and limb metabolic condition , pharmacokinetic , pharmaco - dynamics and psychological conditions , temperature , or combination thereof and their trends . the device can include an automatic alarm system for warning a patient of an out of tolerance condition .