if not otherwise specified or clear from context , the following terms as used herein have the following meetings : a . “ alkyl ” as used herein is a saturated or unsaturated hydrocarbon moiety , e . g ., one to twenty - four carbon atoms in length , which may be linear or branched ( e . g ., n - butyl or tert - butyl ), preferably linear , saturated or unsaturated unless otherwise specified . for example , “ c 1 - 24 alkyl ” denotes alkyl having 1 to 24 carbon atoms . in one embodiment , alkyl is optionally substituted with one or more hydroxy or c 1 - 22 alkoxy ( e . g ., ethoxy ) groups . in another embodiment , alkyl contains 1 to 24 carbon atoms , preferably straight chain and optionally saturated or unsaturated , for example r 1 is an alkyl chain containing 1 to 24 carbon atoms , e . g ., 6 - 15 carbon atoms , 16 - 24 carbon atoms , e . g ., so that together with the — c ( o )— to which it attaches , e . g ., when cleaved from the compound , forms the residue of a natural or unnatural , saturated or unsaturated fatty acid . in still another embodiment , alkyl contains 1 to 6 carbon atoms . unless otherwise indicated , the compounds of the invention includes the compounds of formula i , i ( a ), i ( b ) or any of formulae 1 . 1 - 1 . 38 as hereinbefore described , formula ii , ii ( a ), ii ( b ) or any of formulae 2 . 1 - 2 . 31 , in free or pharmaceutically acceptable salt form ; or a compound of formula iii or any of formulae 3 . 1 - 3 . 19 as hereinbefore described ; and a compound of formula iv or any of formulae 4 . 1 - 4 . 4 as hereinbefore described , in free or pharmaceutically acceptable salt form . in certain embodiment , e . g ., depot formulation , the compound of formula q is also included in the compounds of the invention . the compounds of formula ii , ii ( a ), ii ( b ) or any of formulae 2 . 1 - 2 . 31 and the compounds of formula iv or any of formulae 4 . 1 - 4 . 4 as hereinbefore described , may exist in free or salt , e . g ., as acid addition salt , form . an acid - addition salt of a compound of the invention which is sufficiently basic , for example , an acid - addition salt with , for example , an inorganic or organic acid , for example hydrochloric , hydrobromic , sulphuric , phosphoric , acid acetic , trifluoroacetic , citric , maleic acid , toluene sulfonic , propionic , succinic , glycolic , stearic , lactic , malic , tartaric , citric , ascorbic , pamoic , hydroxymaleic , phenylacetic , glutamic , benzoic , salicylic , sulfanilic , 2 - acetoxybenzoic , fumaric , toluenesulfonic , methanesulfonic , ethane disulfonic , oxalic , isethionic acid , and the like . in addition a salt of a compound of the invention which is sufficiently acidic is an alkali metal salt , for example a sodium or potassium salt , an alkaline earth metal salt , for example a calcium or magnesium salt , an ammonium salt or a salt with an organic base which affords a physiologically - acceptable cation , for example a salt with methylamine , dimethylamine , trimethylamine , piperidine , morpholine or tris -( 2 - hydroxyethyl )- amine . in a particular embodiment , the salt of the compounds of the invention is a toluenesulfonic acid addition salt . in another particular embodiment , the salt of the compounds of the invention is a fumeric acid addition salt . in a particular embodiment , the salt of the compounds of the invention is a phosphoric acid addition salt . the compounds of the invention are intended for use as pharmaceuticals , therefore pharmaceutically acceptable salts are preferred . salts which are unsuitable for pharmaceutical uses may be useful , for example , for the isolation or purification of free compounds of the invention , and are therefore also included . the compounds of the invention may comprise one or more chiral carbon atoms . the compounds thus exist in individual isomeric , e . g ., enantiomeric or diasteriomeric form or as mixtures of individual forms , e . g ., racemic / diastereomeric mixtures . any isomer may be present in which the asymmetric center is in the ( r )-, ( s )-, or ( r , s )- configuration . the invention is to be understood as embracing both individual optically active isomers as well as mixtures ( e . g ., racemic / diasteromeric mixtures ) thereof . accordingly , the compounds of the invention may be a racemic mixture or it may be predominantly , e . g ., in pure , or substantially pure , isomeric form , e . g ., greater than 70 % enantiomeric / diastereomeric excess (“ ee ”), preferably greater than 80 % ee , more preferably greater than 90 % ee , most preferably greater than 95 % ee . the purification of said isomers and the separation of said isomeric mixtures may be accomplished by standard techniques known in the art ( e . g ., column chromatography , preparative tlc , preparative hplc , simulated moving bed and the like ). geometric isomers by nature of substituents about a double bond or a ring may be present in cis ( z ) or trans ( e ) form , and both isomeric forms are encompassed within the scope of this invention . the compounds of the invention exist in prodrug form . the term “ prodrug ” is an art recognized term and refers to a drug precursor prior to administration , but generates or releases the active metabolite in vivo following administration , via some chemical or physiological process . for example , the compounds of formula i et seq . will be cleaved to release the active compound : wherein x is — n ( h )—, — n ( c 1 - 6 alkyl )- or — o —; y is — c ( o )—, — o — or — c ( h )( or 4 )—; and r 4 is h . the compounds of formula ii et seq . will be cleaved to release the active compound : wherein x is — n ( h )—; y is — c ( o )—, — o — or — c ( h )( or 4 )—; and r 4 is h . the compounds of formula iii et seq . will be cleaved to release the active compound : wherein x is — n ( h )—, — n ( c 1 - 4 alkyl )- or — o —; r 1 is h or c 1 - 6 alkyl ( e . g ., methyl ); and r 2 is h or or 3 wherein r 3 is h , provided that r 1 and r 2 are not both h , and r 1 and r 3 are not both h . the compounds of formula iv et seq . will be cleaved to release the active compound : wherein r 1 is h or c 1 - 6 alkyl ( e . g ., methyl ); r 2 is h or or 3 wherein r 3 is h ; provided that r 1 and r 2 are not both h , and r 1 and r 3 are not both h . the prodrug compounds of the invention are particularly useful for sustained - and / or delayed release so as to achieve a long acting effect , e . g ., wherein the active compounds as hereinbefore described or the active compound of formula q are released over a period of from about 7 to about 14 to about 30 to about 180 days , preferably over about 30 or about 60 or about 90 days , for example as described in any of formulae 6 . 1 - 6 . 5 or 5 . 1 - 5 . 5 which comprises a viscosity enhancing agent as discussed above . preferably , the sustained and / or delayed - release formulation is an injectable formulation . alternatively and / or additionally , the compounds of the invention and the compound of formula q may be included as a depot formulation , e . g ., by dispersing , dissolving or encapsulating the compounds of the invention in a polymeric matrix as described in any of composition 6 . 1 - 6 . 5 , such that the compound is continually released as the polymer degrades over time . the release of the compounds of the invention or the compound of formula q from the polymeric matrix provides for the controlled - and / or delayed - and / or sustained - release of the compounds , e . g ., from the pharmaceutical depot composition , into a subject , for example a warm - blooded animal such as man , to which the pharmaceutical depot is administered . thus , the pharmaceutical depot delivers the active compounds described hereinbefore or the compound of formula q to the subject at concentrations effective for treatment of the particular disease or medical condition over a sustained period of time , e . g ., 7 - 180 days , preferably about 7 or about 14 or about 30 , about 60 or about 90 days . polymers useful for the polymeric matrix in the composition of the invention ( e . g ., depot composition of any of formulae 6 . 1 - 6 . 5 ) may include a polyester of a hydroxyfatty acid and derivatives thereof or other agents such as polylactic acid , polyglycolic acid , polycitric acid , polymalic acid , poly - beta .- hydroxybutyric acid , epsilon .- capro - lactone ring opening polymer , lactic acid - glycolic acid copolymer , 2 - hydroxybutyric acid - glycolic acid copolymer , polylactic acid - polyethyleneglycol copolymer or polyglycolic acid - polyethyleneglycol copolymer ), a polymer of an alkyl alpha - cyanoacrylate ( for example poly ( butyl 2 - cyanoacrylate )), a polyalkylene oxalate ( for example polytrimethylene oxalate or polytetramethylene oxalate ), a polyortho ester , a polycarbonate ( for example polyethylene carbonate or polyethylenepropylene carbonate ), a polyortho - carbonate , a polyamino acid ( for example poly - gamma .- l - alanine , poly -. gamma .- benzyl - l - glutamic acid or poly - y - methyl - l - glutamic acid ), a hyaluronic acid ester , and the like , and one or more of these polymers can be used . if the polymers are copolymers , they may be any of random , block and / or graft copolymers . when the above alpha - hydroxycarboxylic acids , hydroxydicarboxylic acids and hydroxytricarboxylic acids have optical activity in their molecules , any one of d - isomers , l - isomers and / or dl - isomers may be used . among others , alpha - hydroxycarboxylic acid polymer ( preferably lactic acid - glycolic acid polymer ), its ester , poly - alpha - cyanoacrylic acid esters , etc . may be used , and lactic acid - glycolic acid copolymer ( also referred to as poly ( lactide - alpha - glycolide ) or poly ( lactic - co - glycolic acid ), and hereinafter referred to as plga ) are preferred . thus , in one aspect the polymer useful for the polymeric matrix is plga . as used herein , the term plga includes polymers of lactic acid ( also referred to as polylactide , poly ( lactic acid ), or pla ). most preferably , the polymer is the biodegradable poly ( d , l - lactide - co - glycolide ) polymer . in a preferred embodiment , the polymeric matrix of the invention is a biocompatible and biodegradable polymeric material . the term “ biocompatible ” is defined as a polymeric material that is not toxic , is not carcinogenic , and does not significantly induce inflammation in body tissues . the matrix material should be biodegradable wherein the polymeric material should degrade by bodily processes to products readily disposable by the body and should not accumulate in the body . the products of the biodegradation should also be biocompatible with the body in that the polymeric matrix is biocompatible with the body . particular useful examples of polymeric matrix materials include poly ( glycolic acid ), poly - d , l - lactic acid , poly - l - lactic acid , copolymers of the foregoing , poly ( aliphatic carboxylic acids ), copolyoxalates , polycaprolactone , polydioxonone , poly ( ortho carbonates ), poly ( acetals ), poly ( lactic acid - caprolactone ), polyorthoesters , poly ( glycolic acid - caprolactone ), polyanhydrides , and natural polymers including albumin , casein , and waxes , such as , glycerol mono - and distearate , and the like . the preferred polymer for use in the practice of this invention is dl ( polylactide - co - glycolide ). it is preferred that the molar ratio of lactide to glycolide in such a copolymer be in the range of from about 75 : 25 to 50 : 50 . useful plga polymers may have a weight - average molecular weight of from about 5 , 000 to 500 , 000 daltons , preferably about 150 , 000 daltons . dependent on the rate of degradation to be achieved , different molecular weight of polymers may be used . for a diffusional mechanism of drug release , the polymer should remain intact until all of the drug is released from the polymeric matrix and then degrade . the drug can also be released from the polymeric matrix as the polymeric excipient bioerodes . the plga may be prepared by any conventional method , or may be commercially available . for example , plga can be produced by ring - opening polymerisation with a suitable catalyst from cyclic lactide , glycolide , etc . ( see ep - 0058481b2 ; effects of polymerization variables on plga properties : molecular weight , composition and chain structure ). it is believed that plga is biodegradable by means of the degradation of the entire solid polymer composition , due to the break - down of hydrolysable and enzymatically cleavable ester linkages under biological conditions ( for example in the presence of water and biological enzymes found in tissues of warm - blooded animals such as humans ) to form lactic acid and glycolic acid . both lactic acid and glycolic acid are water - soluble , non - toxic products of normal metabolism , which may further biodegrade to form carbon dioxide and water . in other words , plga is believed to degrade by means of hydrolysis of its ester groups in the presence of water , for example in the body of a warm - blooded animal such as man , to produce lactic acid and glycolic acid and create the acidic microclimate . lactic and glycolic acid are by - products of various metabolic pathways in the body of a warm - blooded animal such as man under normal physiological conditions and therefore are well tolerated and produce minimal systemic toxicity . in another embodiment , the polymeric matrix useful for the invention may comprise a star polymer wherein the structure of the polyester is star - shaped . these polyesters have a single polyol residue as a central moiety surrounded by acid residue chains . the polyol moiety may be , e . g ., glucose or , e . g ., mannitol . these esters are known and described in gb 2 , 145 , 422 and in u . s . pat . no . 5 , 538 , 739 , the contents of which are incorporated by reference . the star polymers may be prepared using polyhydroxy compounds , e . g ., polyol , e . g ., glucose or mannitol as the initiator . the polyol contains at least 3 hydroxy groups and has a molecular weight of up to about 20 , 000 daltons , with at least 1 , preferably at least 2 , e . g ., as a mean 3 of the hydroxy groups of the polyol being in the form of ester groups , which contain polylactide or co - polylactide chains . the branched polyesters , e . g ., poly ( d , 1 - lactide - co - glycolide ) have a central glucose moiety having rays of linear polylactide chains . the depot composition of the invention ( e . g ., compositions of any of formulae 6 . 1 - 6 . 5 ) as hereinbefore described may comprise the polymer in the form of microparticles or nanoparticles , or in a liquid form , with the compounds of the invention dispersed or encapsulated therein . “ microparticles ” is meant solid particles that contain the compounds of the invention either in solution or in solid form wherein such compound is dispersed or dissolved within the polymer that serves as the matrix of the particle . by an appropriate selection of polymeric materials , a microparticle formulation can be made in which the resulting microparticles exhibit both diffusional release and biodegradation release properties . when the polymer is in the form of microparticles , the microparticles may be prepared using any appropriate method , such as by a solvent evaporation or solvent extraction method . for example , in the solvent evaporation method , the compounds of the invention and the polymer may be dissolved in a volatile organic solvent ( for example a ketone such as acetone , a halogenated hydrocarbon such as chloroform or methylene chloride , a halogenated aromatic hydrocarbon , a cyclic ether such as dioxane , an ester such as ethyl acetate , a nitrile such as acetonitrile , or an alcohol such as ethanol ) and dispersed in an aqueous phase containing a suitable emulsion stabiliser ( for example polyvinyl alcohol , pva ). the organic solvent is then evaporated to provide microparticles with the compounds of the invention encapsulated therein . in the solvent extraction method , the compounds of the invention and polymer may be dissolved in a polar solvent ( such as acetonitrile , dichloromethane , methanol , ethyl acetate or methyl formate ) and then dispersed in an aqueous phase ( such as a water / pva solution ). an emulsion is produced to provide microparticles with the compounds of the invention encapsulated therein . spray drying is an alternative manufacturing technique for preparing the microparticles . another method for preparing the microparticles of the invention is also described in both u . s . pat . no . 4 , 389 , 330 and u . s . pat . no . 4 , 530 , 840 . the microparticle of the present invention can be prepared by any method capable of producing microparticles in a size range acceptable for use in an injectable composition . one preferred method of preparation is that described in u . s . pat . no . 4 , 389 , 330 . in this method the active agent is dissolved or dispersed in an appropriate solvent . to the agent - containing medium is added the polymeric matrix material in an amount relative to the active ingredient that provides a product having the desired loading of active agent . optionally , all of the ingredients of the microparticle product can be blended in the solvent medium together . solvents for the compounds of the invention or the compound of formula q and the polymeric matrix material that can be employed in the practice of the present invention include organic solvents , such as acetone ; halogenated hydrocarbons , such as chloroform , methylene chloride , and the like ; aromatic hydrocarbon compounds ; halogenated aromatic hydrocarbon compounds ; cyclic ethers ; alcohols , such as , benzyl alcohol ; ethyl acetate ; and the like . in one embodiment , the solvent for use in the practice of the present invention may be a mixture of benzyl alcohol and ethyl acetate . further information for the preparation of microparticles useful for the invention can be found in u . s . patent publication number 2008 / 0069885 , the contents of which are incorporated herein by reference in their entirety . the amount of the compounds of the invention or the compounds of formula q incorporated in the microparticles usually ranges from about 1 wt % to about 90 wt . %, preferably 30 to 50 wt . %, more preferably 35 to 40 wt . %. by weight % is meant parts of the compounds of the invention per total weight of microparticle . the pharmaceutical depot may comprise a pharmaceutically - acceptable diluent or carrier , such as a water miscible diluent or carrier . details of osmotic - controlled release oral delivery system composition may be found in ep 1 539 115 ( u . s . pub . no . 2009 / 0202631 ) and wo 2000 / 35419 , the contents of each of which are incorporated by reference in their entirety . a “ therapeutically effective amount ” is any amount of the compounds of the invention ( for example as contained in the pharmaceutical depot ) which , when administered to a subject suffering from a disease or disorder , is effective to cause a reduction , remission , or regression of the disease or disorder over the period of time as intended for the treatment . dosages employed in practicing the present invention will of course vary depending , e . g . on the particular disease or condition to be treated , the particular compound of the invention used , the mode of administration , and the therapy desired . unless otherwise indicated , an amount of the compound of the invention for administration ( whether administered as a free base or as a salt form ) refers to or is based on the amount of the active drug compound in free base form or in pharmaceutically acceptable salt form ( i . e ., the calculation of the amount is based on the free base amount or pharmaceutically acceptable salt amount and in a non - prodrug form ). therefore , the dosage is based on the amount of the compound of formula q , wherein x is — n ( ch 3 )— and y is — c (═ o ), in free base form and non - prodrug form ( i . e ., wherein the prodrug , e . g ., substituent r 5 of formula ii or the group — c ( o )— o — c ( r a )( r b )( r c ) or — c ( r 6 )( r 7 )— o — c ( o )— r 8 on the quarternary ammonium nitrogen of formula i , is cleaved off wherein x is — n ( ch 3 )— and y is — c (═ o )). in another embodiment , the dosage is based on the amount of the compound of formula q , wherein x is — n ( ch 3 )— and y is — c (═ o ), in pharmaceutically acceptable salt and non - prodrug form ( i . e ., wherein the prodrug , e . g ., substituent r 5 of formula ii or the group — c ( o )— o — c ( r a )( r b )( r c ) or — c ( r 6 )( r 7 )— o — c ( o )— r 8 on the quarternary ammonium nitrogen of formula i , is cleaved off wherein x is — n ( ch 3 )— and y is — c (═ o )). the compounds of the invention may be administered by any satisfactory route , including orally , parenterally ( intravenously , intramuscular or subcutaneous ) or transdermally , but are preferably administered orally . in certain embodiment , the compounds of the invention , e . g ., in depot formulation ( e . g ., formulae 5 . 1 - 5 . 5 or 6 . 1 - 6 . 5 ), is preferably administered parenterally , e . g ., by injection . in general , satisfactory results for method i or iii or any of formulae 8 . 1 - 8 . 52 or use of the compounds of the invention or the compounds of formula q as hereinbefore described , e . g . for the treatment of a combination of diseases such as a combination of at least depression , psychosis , e . g ., ( 1 ) psychosis , e . g ., schizophrenia , in a patient suffering from depression ; ( 2 ) depression in a patient suffering from psychosis , e . g ., schizophrenia ; ( 3 ) mood disorders associated with psychosis , e . g ., schizophrenia , or parkinson &# 39 ; s disease ; and ( 4 ) sleep disorders associated with psychosis , e . g ., schizophrenia , or parkinson &# 39 ; s disease , as set forth above are indicated to be obtained on oral administration at dosages of the order from about 1 mg to 100 mg once daily , preferably 2 . 5 mg - 50 mg , e . g ., 2 . 5 mg , 5 mg , 10 mg , 20 mg , 30 mg , 40 mg or 50 mg in free base or pharmaceutically acceptable , non - prodrug form , once daily , preferably via oral administration . preferably , the daily dosage is 20 mg - 40 mg in free base or pharmaceutically acceptable , non - prodrug form . for example , the method of treating schizophrenia or dementia ( e . g ., in methods i and iii ) comprises a daily dosage of 20 - 40 mg in free base or pharmaceutically acceptable , non - prodrug form . satisfactory results for method ii or any of 9 . 1 - 9 . 15 , or use of the compounds of the invention or compounds or formula q as hereinbefore described , e . g . for the treatment of sleep disorder alone are indicated to be obtained on oral administration at dosages of the order from about 2 . 5 mg - 5 mg , e . g ., 2 . 5 mg , 3 mg , 4 mg or 5 mg , of a compound of the invention , in free or pharmaceutically acceptable salt form , once daily , preferably via oral administration . satisfactory results for method i - a or any of 10 . 1 - 10 . 38 are indicated to be obtained at less than 100 mg , preferably less than 50 mg , e . g ., less than 40 mg , less than 30 mg , less than 20 mg , less than 10 mg , less than 5 mg , less than 2 . 5 mg in free base or pharmaceutically acceptable , non - prodrug form , once daily . satisfactory results for method ii - a or any of 10 . 1 - 10 . 38 are indicated to be obtained at less than 5 mg , preferably less than 2 . 5 mg in free base or pharmaceutically acceptable , non - prodrug form . for treatment of the disorders disclosed herein wherein the depot composition is used to achieve longer duration of action , the dosages will be higher relative to the shorter action composition , e . g ., higher than 1 - 100 mg , e . g ., 25 mg , 50 mg , 100 mg , 500 mg , 1 , 000 mg , or greater than 1000 mg in free base or pharmaceutically acceptable , non - prodrug form . for example , for the treatment of psychosis , schizophrenia or dementia ( methods i or iii ), the weekly biweekly and monthly dosages may be about 100 mg - 300 mg ( e . g ., 140 mg - 160 mg ), about 250 mg - 600 mg ( e . g ., 280 - 300 mg ) and about 500 - 1 , 240 mg ( e . g ., 600 mg - 620 mg ) of the compound of the invention based on the free base or pharmaceutically acceptable salt and non - prodrug form . duration of action of the compounds of the invention may be controlled by manipulation of the polymer composition , i . e ., the polymer : drug ratio and microparticle size . wherein the composition of the invention is a depot composition , administration by injection is preferred . the pharmaceutically acceptable salts of the compounds of the invention can be synthesized from the parent compound which contains a basic or acidic moiety by conventional chemical methods . generally , such salts can be prepared by reacting the free base forms of these compounds with a stoichiometric amount of the appropriate acid in water or in an organic solvent , or in a mixture of the two ; generally , nonaqueous media like ether , ethyl acetate , ethanol , isopropanol , or acetonitrile are preferred . further details for the preparation of these salts , e . g ., toluenesulfonic salt in amorphous or crystal form , may be found in pct / us08 / 03340 and / or u . s . provisional appl . no . 61 / 036 , 069 . pharmaceutical compositions comprising compounds of the invention may be prepared using conventional diluents or excipients ( an example include , but is not limited to sesame oil ) and techniques known in the galenic art . thus oral dosage forms may include tablets , capsules , solutions , suspensions and the like . the compounds of formulae i , i ( a ), i ( b ) and 1 . 1 - 1 . 38 as hereinbefore described may be prepared by reacting the compound of formula a , wherein x and y are defined in any of formulae i , i ( a ), i ( b ) or 1 . 1 - 1 . 37 : with l - c ( r 6 )( r 7 )— oc ( o )— r 8 wherein l is a leaving group such as halo , preferably iodo and r 6 , r 7 and r 8 are as defined in any of formulae i , i ( a ), i ( b ) or 1 . 1 - 1 . 38 , preferably r 6 and r 7 are h and r 8 is c 9 alkyl . l - c ( r 6 )( r 7 )— oc ( o )— r 8 , in turn , may be prepared by reacting cl — c ( o )— r 8 with zinc chloride and paraformaldehyde followed by reacting the resulting cl — l - c ( r 6 )( r 7 )— oc ( o )— r 8 with sodium iodide . r 6 , r 7 and r 8 are as defined in any of formulae i , i ( a ), i ( b ) or 1 . 1 - 1 . 38 , preferably r 2 and r 3 are h and r 1 is c 9 alkyl . the compounds of formulae ii , ii ( a ), ii ( b ) and 2 . 1 - 2 . 31 , in free or pharmaceutically acceptable salt form as hereinbefore described may be prepared by reacting the compound of formula b : wherein y is as defined in any of formulae ii , ii ( a ), ii ( b ) or 2 . 1 - 2 . 31 , with triphosgene and a base ( e . g ., pyridine ) in a solvent such as dichloromethane . the resulting chloride - carbonyl derivative of formula b may then be reacted with ho — c ( r a )( r b )( r c ) to produce the compounds of any of formulae ii , ii ( a ), ii ( b ) or 2 . 1 - 2 . 31 , wherein r 5 is — c ( o )— o — c ( r a )( r b )( r c ). the compounds of formulae ii , ii ( a ), ii ( b ) and 2 . 1 - 2 . 31 , wherein r 5 is — c ( r 6 )( r 7 )— o — c ( o )— r 8 , in free or pharmaceutically acceptable salt form may be prepared by reacting the compound of formula b with l - c ( r 6 )( r 7 )— oc ( o )— r 8 wherein l is a leaving group such as halo ( e . g ., iodo ) and r 6 , r 7 and r 8 are as defined in any of formulae ii , ii ( a ), ii ( b ) and 2 . 1 - 2 . 31 . the compounds of formula a and formula b may be prepared by methods disclosed in any of u . s . pat . no . 8 , 309 , 722 , wo 2011 / 133224 , wo 2008 / 112280 ; u . s . pat . nos . 6 , 548 , 493 ; 7 , 238 , 690 ; 6 , 552 , 017 ; 6 , 713 , 471 ; 7 , 183 , 282 ; u . s . re39680 , and u . s . re39679 , the contents of each of which are incorporated by reference in their entirety . the compounds of formula iii and 3 . 1 - 3 . 19 wherein r 2 is — or 3 and r 3 is h as hereinbefore described may be may be prepared by reacting formula c with a grignard reagent , r 1 — mgx 2 wherein x 2 is halide , e . g ., bromide or chloride , preferably bromide , r 1 and x are defined in formula iii , e . g ., r 1 is methyl and x is for example n ( ch 3 ), e . g ., in a solvent such as tetrahydrofuran or diethyl ether , preferably tetrahydrofuran . the reaction may be summarized in the reaction scheme below : the compound of formula iii , wherein r 2 is — or 3 wherein r 3 is c 1 - 6 alkyl may be prepared by reacting formula d with r 3 — oh and bf 3 . oet wherein r 3 is c 1 - 6 alkyl . the reaction may be summarized in the reaction scheme below : the compounds of formulae iii and iv may be prepared by using the compounds of formula d and formula e wherein x , r 1 and r 3 are as defined in any of formulae iii , and iv and the procedures described for formula i , i ( a ), i ( b ) and ii , ii ( a ) and ii ( b ). isolation or purification of the disastereomers of the compounds of the invention may be achieved by conventional methods known in the art , e . g ., column purification , preparative thin layer chromatography , preparative hplc , crystallization , trituration , simulated moving beds and the like . salts of the compounds of the invention such as compounds of formula ii and iv may be prepared as similarly described in u . s . pat . nos . 6 , 548 , 493 ; 7 , 238 , 690 ; 6 , 552 , 017 ; 6 , 713 , 471 ; 7 , 183 , 282 ; u . s . re39680 ; u . s . re39679 ; and wo 2009 / 114181 , the contents of each of which are incorporated by reference in their entirety . waters acquity uplc system : acquity hss t3 column , 50 mm × 2 . 1 mm , 1 . 8 m , 25 ° c . ; mobile phase a , 0 . 1 % formic acid in water / acetonitrile ( 95 / 5 ); mobile phase b , 0 . 1 % formic acid in acetonitrile ; gradient , 0 . 0 - 3 . 0 min , 5 - 95 % b ; 3 . 0 - 4 . 0 min , 95 % b ; 4 . 0 - 5 . 0 min , 95 - 5 % b ; flow rate 0 . 3 ml / min ; detection at 210 - 400 nm . all products are purified with a waters semi - preparative hplc system , which is equipped with a delta 600ef pump and a 996 pda detector . column : gemini , axia packed , 10 μm c18 110 å , 250 × 21 . 2 mm ; mobile phase a , 0 . 1 % formic acid in water ; mobile phase b , acetonitrile ; gradient is adjusted and optimized based on compound polarity ; hplc run time was 22 min ; flow rate was 23 . 8 ml / min ; detection was at 210 - 350 nm . to a solution of decanoyl chloride ( 1 . 63 ml 4 . 2 mmol ) and paraformaldehyde ( 126 mg ) in acetone ( 6 ml ) is added zinc chloride . the reaction mixture is stirred at 65 ° c . overnight . sodium iodide ( 1 . 9 g , 12 . 6 mmol ) is added into the reaction mixture , and the mixture is stirred at room temperature overnight . the reaction mixture is filtered and acetone is removed under reduced pressure . the residue is treated with hexanes , and then filtered . the filtrate is evaporated to dryness under vacuum to give the crude iodomethyl decanoate , which is used in the next step without further purification . to a solution of the 4 -(( 6br , 10as )- 3 - methyl - 2 , 3 , 6b , 9 , 10 , 10a - hexahydro - 1h , 7h - pyrido [ 3 ′, 4 ′: 4 , 5 ] pyrrolo [, 2 , 3 - de ] quinoxalin - 8 - yl )- 1 -( 4 - fluorophenyl )- butan - 1 - one ( 27 mg , 0 . 065 mmol ) in methylene chloride ( 250 ul ) is added the crude iodomethyl decanoate ( 32 mg , 0 . 10 mmol ). the reaction mixture is stirred at room temperature for 3 days , and then purified with a semi - preparative hplc ( gemini column , axia packed , 10 mm c18 110 å , 250 ′ 21 . 2 mm ; mobile phase a , 0 . 1 % formic acid in water ; mobile phase b , 0 . 1 % formic acid in acetonitrile ; gradient is adjusted and optimized based on compound polarity ; run time 22 min ; flow rate 24 ml / min ; detection at 210 - 350 nm ) to give ( 6br , 10as )- 8 - decanoyloxymethyl - 8 -[ 4 -( 4 - fluoro - phenyl )- 4 - oxo - butyl ]- 3 - methyl - 2 , 3 , 6b , 7 , 8 , 9 , 10 , 10a - octahydro - h - pyrido [ 3 ′, 4 ′: 4 , 5 ] pyrrolo [ 1 , 2 , 3 - de ] quinoxalin - 8 - ium formate . esi - ms ( m / z , positive mode ): 578 . 4 . alternatively , the compound of example 1 may be prepared as follows : to a solution of the 4 -(( 6br , 10as )- 3 - methyl - 2 , 3 , 6b , 9 , 10 , 10a - hexahydro - 1h , 7h - pyrido [ 3 ′, 4 ′: 4 , 5 ] pyrrolo [ 1 , 2 , 3 - de ] quinoxalin - 8 - yl )- 1 -( 4 - fluorophenyl )- butan - 1 - one ( 50 . 8 mg , 0 . 13 mmol ) in acetonitrile ( 2 . 5 ml ) is added chloromethyl decanoate ( 32 . 7 mg , 0 . 14 mmol ), followed by adding nai ( 61 mg , 0 . 41 mmol ). the reaction mixture is stirred at room temperature over a weekend , and then filtered . the obtained filtrate is purified with a semi - preparative hplc using a gradient of 0 - 48 % b ( gradient curve 4 ) to give ( 6br , 10as )- 8 - decanoyloxymethyl - 8 -[ 4 -( 4 - fluoro - phenyl )- 4 - oxo - butyl ]- 3 - methyl - 2 , 3 , 6b , 7 , 8 , 9 , 10 , 10a - octahydro - 1h - pyrido [ 3 ′, 4 ′: 4 , 5 ] pyrrolo [ 1 , 2 , 3 - de ] quinoxalin - 8 - ium formate ( 20 mg , 25 % yield ). uplc retention time : 3 . 29 min . esi - ms ( m / z , positive mode ): 578 . 3 . to a solution of the 4 -(( 6br , 10as )- 3 - methyl - 2 , 3 , 6b , 9 , 10 , 10a - hexahydro - 1h , 7h - pyrido [ 3 ′, 4 ′: 4 , 5 ] pyrrolo [ 1 , 2 , 3 - de ] quinoxalin - 8 - yl )- 1 -( 4 - fluorophenyl )- butan - 1 - one ( 48 . 0 mg , 0 . 12 mmol ) in acetonitrile ( 2 . 0 ml ) is added chloromethyl isopropyl carbonate ( 25 . 0 mg , 0 . 16 mmol ), followed by adding nai ( 60 . 0 mg , 0 . 40 mmol ). the reaction mixture is stirred at room temperature over a weekend , and then filtered . the obtained filtrate is purified with a semi - preparative hplc using a gradient of 0 - 35 % b ( gradient curve 4 ) to give ( 6br , 10as )- 8 -[ 4 -( 4 - fluoro - phenyl )- 4 - oxo - butyl ]- 8 - isopropoxycarbonyloxymethyl - 3 - methyl - 2 , 3 , 6b , 7 , 8 , 9 , 10 , 10a - octahydro - 1h - pyrido [ 3 ′, 4 ′: 4 , 5 ] pyrrolo [ 1 , 2 , 3 - de ] quinoxalin - 8 - ium formate ( 50 mg , 75 % yield ). uplc retention time : 2 . 49 min . esi - ms ( m / z , positive mode ): 510 . 3 . to a solution of the 4 -(( 6br , 10as )- 3 - methyl - 2 , 3 , 6b , 9 , 10 , 10a - hexahydro - 1h , 7h - pyrido [ 3 ′, 4 ′: 4 , 5 ] pyrrolo [ 1 , 2 , 3 - de ] quinoxalin - 8 - yl )- 1 -( 4 - fluorophenyl )- butan - 1 - one ( 49 . 0 mg , 0 . 12 mmol ) in acetonitrile ( 3 . 0 ml ) is added chloromethyl pivalate ( 19 μl , 0 . 12 mmol ), followed by adding nai ( 50 . 0 mg , 0 . 33 mmol ). the reaction mixture is stirred at room temperature overnight , and then filtered . the obtained filtrate is purified with a semi - preparative hplc using a gradient of 0 - 35 % b ( gradient curve 4 ) to give ( 6br , 10as )- 8 -( 2 , 2 - dimethyl - propionyloxymethyl )- 8 -[ 4 -( 4 - fluoro - phenyl )- 4 - oxo - butyl ]- 3 - methyl - 2 , 3 , 6b , 7 , 8 , 9 , 10 , 10a - octahydro - 1h - pyrido [ 3 ′, 4 ′: 4 , 5 ] pyrrolo [ 1 , 2 , 3 - de ] quinoxalin - 8 - ium formate . uplc retention time : 2 . 48 min . esi - ms ( m / z , positive mode ): 508 . 3 . a solution of chloromethyl carbonochloridate ( 1 . 0 ml ) in ch 2 cl 2 ( 10 ml ) is cooled to − 10 ° c ., and then a solution of hexan - 1 - amine ( 1 . 3 ml ) and pyridine ( 0 . 9 ml ) in ch 2 cl 2 ( 2 . 5 ml ) is added dropwise . the reaction mixture is gradually warmed up to room temperature and then stirred at room temperature for 4 h . the mixture is washed with hcl ( 1n , 5 . 0 ml ), h 2 o ( 20 ml ) and saturated nahco 3 ( 5 . 0 ml ), successively , and then dried over mgso 4 . after the solvents are removed , the obtained crude chloromethyl hexylcarbamate is used directly in the next step without further purification . to a solution of the 4 -(( 6br , 10as )- 3 - methyl - 2 , 3 , 6b , 9 , 10 , 10a - hexahydro - 1h , 7h - pyrido [ 3 ′, 4 ′: 4 , 5 ] pyrrolo [ 1 , 2 , 3 - de ] quinoxalin - 8 - yl )- 1 -( 4 - fluorophenyl )- butan - 1 - one ( 54 mg , 0 . 14 mmol ) in acetonitrile ( 1 . 0 ml ) is added crude chloromethyl hexylcarbamate ( 86 mg , 0 . 41 mmol ), followed by adding nai ( 65 mg , 0 . 41 mmol ). the reaction mixture is stirred at room temperature overnight , and then filtered . the obtained filtrate is purified with a semi - preparative hplc using a gradient of 0 - 30 % b ( gradient curve 4 ) to give ( 6br , 10as )- 8 -[ 4 -( 4 - fluoro - phenyl )- 4 - oxo - butyl ]- 8 - hexylcarbamoyloxymethyl - 3 - methyl - 2 , 3 , 6b , 7 , 8 , 9 , 10 , 10a - octahydro - h - pyrido [ 3 ′, 4 ′: 4 , 5 ] pyrrolo [ 1 , 2 , 3 - de ] quinoxalin - 8 - ium formate . uplc retention time : 2 . 04 min . esi - ms ( m / z , positive mode ): 551 . 3 . pharmacokinetic evaluation of the prodrugs may be carried as described or similarly described below or in wo 2011 / 084846 , the contents of which are incorporated by reference in their entirety . animals : male sprague - dawley rats ( approximately 24 rats ) may be used in each study . rats may be housed 2 per cage with ad libitum chow and water . environmental conditions in the housing room may be 64 - 67 ° f ., 30 % to 70 % relative humidity , and 12 : 12 - h light : dark cycle . test compounds : an amount of each test compound may be suspended in the vehicle to yield a suspension comprising the equivalent of 3 mg of the compound in free base and non - prodrug form , in 0 . 3 ml . pharmacokinetics study : rats may be dosed im by means of a 23 gauge , 1 in . needle with 1 cc syringe . 0 . 3 ml suspension may be withdrawn from the vial containing the test compound . the rat may be injected in the muscles of the hind limb after anesthesia with isotlourane . blood samples may be collected via a lateral tail vein after brief anesthesia with isoflourane . a 27½g needle and 1 cc syringe without an anticoagulant may be used for the blood collection . approximately 250 μl of whole blood may be collected at each sampling time point of 6 hours , 24 hours and 2 , 5 , 7 , 9 , 12 , 14 days after administration . approximately 450 μl of whole blood may be collected at sampling time points of 21 , 28 and 35 days . once collected , whole blood may immediately be transferred to tubes containing k 2 edta , inverted 10 - 15 times and immediately placed on ice . the tubes may be centrifuged for 2 minutes at & gt ; 14 , 000 × g ( 11500 rpm using eppendorf centrifuge 5417c , f45 - 30 - 11 rotor ) at 4 - 8 ° c . to separate plasma . plasma samples may be transferred to labeled plain tubes ( microtainer ®; mfg # bd5962 ) and stored frozen at & lt ;− 70 ° c . data analysis : drug concentrations in plasma samples may be analyzed by liquid chromatography - mass spectroscopy using appropriate parameters for each compound . half - life , volume of distribution , clearance , maximal concentration , and auc may be calculated by using winnonlin software , version 5 . 2 ( pharsight , st . louis , mo .). the results will show that the prodrug compounds of the invention have a longer t max and / or t 1 / 2 than the parent compound ( e . g ., compound of formula q , e . g ., wherein x is — c ( ch 3 )— and y is — c ( o )— or the active compound hereinbefore described ).
the invention relates to particular substituted heterocycle fused gamma - carbolines , their prodrugs , in free , pharmaceutically acceptable salt and / or substantially pure form as described herein , pharmaceutical compositions thereof , and methods of use in the treatment of diseases involving 5 - ht 2a receptor , serotonin transporter and / or pathways involving dopamine d 2 receptor signaling systems .