Editorial rejection: should I write back? I recently submitted a paper to one of the Physical Review Journals (not Letters). I think that the result is both novel and important. After I uploaded the preprint to ArXiv, I received several emails from researchers in the field whom I do not know personally saying that they liked the paper and it is an important advancement in the understanding. People I personally know reacted similarly. I was sure that the paper would at least be reviewed considering that it seems to be important and that it is not submitted to PRL. 

After two weeks, I got an email from the editor saying that it is being rejected without any review. My friend has got such rejection from the same journal, he received exact same text, which means that it was simply copy pasted. Now, I am a researcher who has a small number of citations, I have never published in Physical Review before and I am from a third world country. My feeling is that these things have biased the editor against the manuscript even though it is a good work if not groundbreaking and he should have at least sent it to reviewers. 

I feel that I should write back to him these concerns. However, I have never done anything like this before and I am not sure if I risk lifetime rejection from the journal if I do this. I would be glad to hear the experienced researchers on this issue.
No doubt your first instinct is to challenge this desk rejection, but I would advise against it. 

It is well known that appeals rarely succeed when referees go against you. When a handling editor thinks your work is not sufficiently interesting, I'd say an appeal is even less likely to be successful.

Coming specifically to Phys. Rev., your situation is somewhat worsened by the fact that alternatives to the Phys. Rev. A-X stable are not as attractive or popular. 

But if your work is sufficiently useful, and helps advance your field, it will get cited even if you take your paper elsewhere. There is evidence for this in your case: You have senior researchers on arXiv giving you good feedback.