Will one flawed grade outside of my major from my freshman year affect graduate school? I'm an English major and planning to apply to graduate schools. My freshman year I originally planned to be a bio major due to pressures from my family. I had to take chemistry and biology, which soon enough turned into a disaster. I dropped chem, but since I needed enough credits to be considered full time, I was forced to keep with bio. I ended up with a D- in the course. If it wasn't my freshman year, I honestly would have probably done better, but I was having a rough time settling into college with homesickness and depression. Aside from that one hiccup, however, the rest of my grades are As with a couple B+. So what I'm wondering is would that badly affect my application or even receiving scholarships?
It is extremely unlikely that a graduate admissions committee/potential supervisor would look at your first year courses in any amount of detail. They are going to focus on the higher-level courses you take in later years, whether or not you do an honours degree/undergrad thesis, etc.

The only way I can see this affecting you is by lowering the overall average grade for your degree (measured in many places as a GPA). Many departments have a minimum GPA/grade requirement to be considered for admission to grad school. However, as long as you get consistently good grades for the rest of your degree, this little slip-up isn't going to matter much.