Post doctoral while working on self employed job I am in need to know if there is a provision wherein I could do a post-doctorate in the USA for a year or two, while I am owning my own Biotechnology firm back in my home country?
This is a complex issue with a lot of variables. If your post-doc is for work completely unrelated to the work of the company then there is probably no serious issue as long as you faithfully complete the required work. 

However, you will also face several issues if there is some relationship. For example, will you have conflicts of interest between the two aspects? That would make it hard-to-impossible to carry on. Likewise, are there intellectual property issues? In other words, is it possible that you will learn something in the post-doc that is, for contractual or other reasons, off-limits to your company. There may be other issues as well if there is any overlap. 

For issues such as these, both the post-doc project PI and a lawyer should be consulted.