Inspiration for great presentations I enjoy creating presentations a lot and I think I have an eye for nice design, however, I tend to always have the same layout/colour scheme/etc. and I'd like to try something new for my defence.

So I've been googling great presentations for hours, and there are heaps of innovative designs but usually these are from outside academia. I still want to convey information in a serious manner. But when looking at websites that intend to give advice for scientific presentations I find the examples horrible and very much 1990s (bullet points...) 

So, in short, can you think of any scientific presentations with unpretentious but great design, which can be found somewhere online?

Edit Thank you for your comments, which definitely include heaps of helpful advice, however, I was less looking for "basic" presentation guidelines but more for design elements, which do not distract the audience but which make the presentation a bit more interesting. For instance, a colleague of mine recently gave a presentation and before each section she'd have a slide with just the title of the section and a photo (e.g. "Methods" and a picture of her lab equipment). I liked that because it structures the presentation and is a nice break from charts, diagrams and (in the worst case) bullet points. So, yes, I am really more looking for inspiration on fonts, colours, using white space, ...
There are two aspects to your question, in my opinion: design and function.

Function. Many have criticized PowerPoint and bullet points and perhaps none so much as Edward Tufte in his essay booklet The Cognitive Style of PowerPoint: Pitching Out Corrupts Within. The defaults of PowerPoint and reliance on bullet points is interesting and "forces" users into a particular form of presentation where bullets are more reminders for the speaker than the audience. From this background an alternative is to use the so-called Assertion-Evidence Structure which takes a very different approach to building slides. 

In the Assertion-Evidence Structure the heading of the slide is the main point of the slide, a take-home message. The slides use graphics extensively to support and high-light the main point. The structure has been shown to yield significant improvements in both audience understanding than normal bullet-point presentations. Se the linked example of the structure.

The Assertion-Evidence slides are not necessarily pretty but they do the job very well so that brings me to the second issue.

Design. When you look at designing slides it is probably easier to list the don'ts than the do's. In general, anything "fancy" easily becomes boring when overdone. Therefore simple is better. I would also add that subtle is better. Do not use strong colours and avoid backgrounds that can clash with the text, either structurally or in terms of colour, after all you want your message to shine. 

So design anything with a principle to do as much as possible with as little as possible and you should be on a good road. I think referring back to Edward Tufte is useful also here.

So taken together, it is not clear what is a well designed presentation depending on whether you are looking at aesthetic impact or factual impact.