Publication- rejection with advising to resubmit I have received a decision letter from a Q1 journal with following remarks:


  Reviewers' comments on your work have now been received.  You will see
  that they are advising against publication of your work.  Therefore I
  must reject it.
  
  However, you may submit in the future better revision after resolving
  all these drawbacks mentioned by the reviewers, and as new revision


While a reviewer has mentioned "major revision", is this decision advising for resubmit after revising the paper? Does this mean "Reject and resubmit"?
While a reviewer has mentioned "major revision", is this decision advising for resubmit after revising the paper? Does this mean "Reject and resubmit"?


Yes, this means your manuscript is rejected, but you are free to submit a new version once you addressed the mentioned problems.

Note that whether one of the reviewers voted for Major Revision rather than Reject is completely irrelevant - it's the editor's decision that counts.