How to reply to editor's comment such as 'Such a revised paper may be refereed and there would be no guarantee of acceptance'? Is it necessary? I am preparing a detailed explanation of how I have dealt with all of the reviewers' and Editor's comments for a manuscript. The editor's comments are as follows: 


  I regret I am unable to accept your paper for publication in XXX, at
  least in its present form. I should, however, be prepared to consider
  for publication a substantially revised version that takes into
  account the suggestions of the referees. Such a revised paper may be
  refereed and there would be no guarantee of acceptance. The three
  referees agree that you have obtained useful results. They raise a
  number of issues you should be able to solve relatively easily.


Is it necessary to reply to editor's comment like this? How to reply to editor's comment such as'Such a revised paper may be refereed and there would be no guarantee of acceptance'?
Is it necessary to reply to editor's comment like this? 


No. This is just making sure that you understand that revising the paper does not guarantee acceptance.

You may wish to write an introductory paragraph for the editor before you address the specific reviewer comments. Here, you may wish to thank the editor for acknowledging that the reviewers consider your results to be useful, summarise the main improvements, and conclude that you feel the manuscript is substantially better for the reviewer suggestions.