What if the lead author disagrees with the coauthors on manuscript content and target journals? The lead author has conceived the initial idea, developed the methods, the experiments, the analysis, and has written the draft. Coauthors have contributed to that draft mainly by rephrasing and restructuring it, in a way that lead author disagrees. 

Additionally, coauthors insist on submitting to a journal which lead author disagrees with, but also the coauthors do not agree for submission on journals which the lead author prefers.

Lead author wants to stop collaborating with the coauthors, but doesn't want to leave this work unpublished (coauthors say they will ask for retraction if work is submitted, since they believe they contributed considerably). Would it be possible for the lead author to omit the coauthors' contributions by rewriting the manuscript, and submit it as the only author?

Given that the solution of negotiating and finding a middle way is excluded, do you have any other solutions to propose?
It seems to me that choosing where to submit is within the responsabilities of the first author. Even though the acceptance of the co-authors is encouraged and desired in order to maintain a healthy relation, I think the last word is his. 

I also think that there's a lack of empathy in this matter. Co-authors should be asking themselves how would they feel in the author's position. How would they feel if they had an idea, developed methods, analysis and drafts and kept being undermined by the rest of the team?

For closure, keep in mind that a work is best if published, regardless of place. Spending all the effort taken because of such disagreement seems petty and dull to me. It is better to let it go and focus on the next project.