Is it wise to try to remove myself from predator mailinglists? A predator journal (Americal Journal of Applied Mathematics) regulary sends me mails about how I should submit to them or join the peer review. Recently I discovered there is a Unsubscribe link in the mail. Now I'm wondering if I should use it.

On one hand, if it works, great.
On the other hand a general rule is not to reply to spam in any way. I can't say where I've heard that but that is my usual MO. But the predator journals are not a fake Nigerian prince, so I'm wondering if I should unsubscribe.

I am aware of the fact I can just mark these mail as spam or delete them automatically with a decent mail client. This alternative is known, but not part of the question. The question is if unsubscribing would be without negative consequences. Maybe someone had some experiences with SciencePG (the predator publisher) or similar groups.

EDIT: For future readers I would like to point out Nav's comment, which links here
The problem is that unsubscribing to the e-mail list requires you to follow a link send to you in e-mail. As general rule this is already something that you should be hesitant to do, even with e-mails from reliable sources. 

A predatory journal is not a reliable source of course. Even if the journal is not actively trying anything dubious with the link, a predatory journal is bound to be a small scale operation, meaning that they are more at risk of having their domain compromised in some way.

If you do decide to follow the link, please take standard precautions like copy-and-pasting the link rather than following it directly, and checking that the link actually leads to a domain controlled by the journal.