Should I revise and resubmit? I have just received a decision letter for my submitted manuscript to an Elsevier journal. It was a revise and resubmit (R&amp;R). Two reviewers comments were included in the decision letter. One of the reviewers suggested minor revisions. The other reviewer on the other hand recommended rejection and his comments were really unfair. Evidently, he hasn't bothered reading the manuscript completely.
I am really disappointed and don't really know how to even respond to his comments. what do you recommend me to do? I am really frustrated.
Most journal articles are often a revise and resubmit before they get published.The final article that you see in journals is often never the first submission attempt but rather, crafted through continuous revising and editing.  

You should revise and resubmit, you would be doing yourself a disfavour if you don't.

The editors had two very contrasting reviewers for your piece, one who suggested a minor revision and the other an outward reject, so a Revise and Resubmit is a pretty good outcome from that, but also highlights a stark contrast of views. 

When you receive harsh comments, it's good to take a step back for a few days and let the anger and frustration that you undoubtedly feel to disappear. At the moment you might feel like it's a bit of a personal attack, and have used language such as 'it's unfair' and 'he hasn't read the article completely.' These are emotional responses and are not helpful for your success. 

Why are the comments unfair and how can you determine whether they've read the article completely? 

When you are ready, sit down and read them with fresh eyes, highlighting what you can do to improve the article. There will be things in there (difficult to find) that you can utilise to strengthen the quality of your article. You don't have to address everything the second reviewer says but you might be surprised that once those personal feelings die down, the number of things you might find helpful from that second reviewer. 

When you do your revision, you'll need to prepare a summary report regarding all the comments, highlighting what you changed, and what you didn't. The things you do not change you provide justification for in your summary report. 

You would be surprised by the number of academics who never bother to revise and resubmit a paper to a journal, the numbers are outstanding. Revising and resubmitting allows for you to continue to improve your ideas and produce something of high quality.