What are the main difficulties for someone who is mute to be successful in academia? There are several posted questions regarding people who have had struggles, but ultimately were able to succeed, in academia while being blind.

My question is regarding being mute (by choice or otherwise): what are the difficulties in being successful? Are there notable examples of such people? I'm not mute myself, but I thought it was an interesting question for the following reasons. 

I would think working in academia means coming up with new and interesting ideas through research, while also conveying these ideas and results in an effective manner to an audience, both through papers and giving talks. So success should be possible in some aspects of academia (such as papers), but not in others (such as giving talks).
I'll open with the obvious answer:

Usually one of the main ways of getting people to know about your work is to give talks about it, in one for or another. It might be possible to mitigate the effect of not giving any talks yourself (eg. by having co-authors doing so, or having a very visible blog), but it would certainly mean taking an unusual approach, at least in my field.