What happens if a reviewer withdraws himself from peer review process? I submitted my manuscript to one of the journal of frontiers groups, It has been 3 months now since the submission, in the first round of the peer review process,  One reviewer gave me minor revision and the second reviewer asked me to do some extensive revision in my manuscript, I complied with the both reviewers and gave them the best answers i could,  to the questions raised by them and resubmitted revised version of my manuscript but after the first round, one reviewer endorsed my manuscript for the publication but the second reviewer withdrew himself from the peer review process and his status shows as an inactive in the interactive review forum. 

I mailed the editor and ask him how the editorial staff will handle my manuscript but didn’t get any response him. 

Has anyone here suffered with a similar dilemma, what usually happens in situations like these, frontiers guidelines mention that they need endorsement from 2 reviewers in order for editor to make a final decision. 

What do editors do in such a situation, do they invite another reviewer?
The two main possibilities are:


Find another reviewer.
Make a decision.


If the editor is sufficiently familiar with the field to check your revision himself, then he might go for #2. Otherwise (or if the journal's policies are inflexible) you might be stuck with #1 and have to wait for another round of reviews.