Is it possible to change paper title after send back from reviewers for revising? Me and my supervisor were written a paper on medical imaging as a part of my master thesis, we sent a paper to a journal for publishing, after a period of time the journal send us back the paper with some comments from each reviewer. In our perspective a number of questions from reviewers comes from a word "Novel" that we wrongly put it in a title. And I want to ask you professionals that is it possible to change the title? is it a good or bad idea? this will make our paper to be refused by reviewers or not?
It's normal to change titles during the review process, sometimes reviewers even ask for it explicitly. 

If it's causing a problem or confusion, change the title.