Is expanding the research of a group into machine learning as a PhD student risky? I have the opportunity of doing a PhD under the supervision of an expert in medical imaging at a top institution. Currently their group does not conduct research into the application of machine learning to medical image acquisition and processing. The purpose of the PhD studentship would be to pursue research into this. The department has significant machine learning and signal processing research groups whose seminars I will be able to attend and academics I can have contact with.

The supervisor has not for some time (before deep learning) pursued research in machine learning. The PhD itself is as yet not strongly structured and will initially require a deal of exploration and prospecting before its final form is decided.

Given that there is a safe fallback of medical imaging I do not foresee a risk to completing the PhD. However, as the only member of the group pursuing machine learning would this be a very risky PhD to embark on, particularly considering that afterwards I intend to pursue a career in academia? Are there any benefits?
I would ask about having a co-supervisor. Having access to esteemed DL researchers is great -- but they will have limited time/interest in helping you if you are not "formally" their student. If you manage to find someone in this role, I think your position is just about perfect. 

If you don't manage to find someone in this role, I have three main concerns:


You will spend a ton of time re-inventing the wheel. For example, can you train a CNN on ImageNet from scratch? There are a lot of caveats needed to obtain state-of-the-art results (e.g., dataset augmentation, regularization loss, etc.), and you will likely rediscover them one-by-one (or, use a black-box model you don't really understand). A DL expert would likely already have working code and could explain it to you, allowing you to jump right to the research. (Yes, there are open source codes...but in my experience, they all require a lot of work to be both transparent and accurate.
Mathematical rigor. It's easy to just learn ML/DL at a "technician level" -- but as a PhD in it, you should really understand it a mathematical level if not a theorem/proof level. It can be difficult to do this on your own.
Problem selection. Your medical advisor will likely find it super novel to run existing techniques on medical images. There may even be a novel application here, on the medical side -- but on the ML side, this is not really interesting, it's just a straightforward application of one technique to a straightforward problem. This is maybe OK if your interest is entirely on the medical side -- but if you want to do something also interesting on the ML side, you would essentially be on your own to come up with something. That will be difficult to do (for the first time) without advisors on both sides.


Those are the main blind alleys I see. Of course, there is also a ton of upside -- this sounds like a very interesting, prestigious position that would position you well for an academic career. Only you can judge this tradeoff.