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L-Glutamine, the most abundant amino acid in your body, plays a crucial role in the metabolism, structure, and normal function of your gastro-intestinal (GI) tract and immune system. It is a major source of fuel for intestinal cells, and helps prevent intestinal permeability by protecting the mucosal lining of the intestines. Increased intestinal permeability can lead to food sensitivities and allergies, dysbiosis, decreased immune function, and chronic inflammation. When the body is under physiological stress, the intestinal tract requires even more glutamine and may benefit from supplementation.
How will L-Glutamine help you?
Helps you avoid additional digestive irritation.
Supports healing in your GI tract.
Makes it easier to absorb the nutrients your body needs.
Our L-Glutamine is:
Made from the highest quality raw materials.
Free of artificial colors, sweeteners, flavors or preservatives.
Laboratory assayed to ensure quality — the same rigorous standard that is used for pharmaceutical drugs.
Our L-Glutamine is a safe, natural digestive GI support formula manufactured to pharmaceutical standards.
The following articles and studies, arranged alphabetically, represent a sampling of the research on L-glutamine.
Ban, K. and Kozar, R. A. 2010. Glutamine protects against apoptosis via down regulation of Sp3 in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 399(6): G1344-G1353. doi: 10.1152/ajpgi.00334.2010. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006244/?tool=pmcentrez (accessed 5/7/2012).
Candow, D. G., et al. 2001. Effect of glutamine supplementation combined with resistance training in young adults. Eur J Appl Physiol., 86(2): 142-9. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/11822473?dopt=Abstract (Accessed 5/9/2012).
Chen, G., et al. 2001. [Clinical observation of the protective effect of oral feeding of glutamine granules on intestinal mucous membrane.] Zhonghua Shao Shang Za Zhi., 17(4):2010.1. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/11876941?dopt=Abstract (accessed 5/9/2012).
Coëffier, M., et al. 2005. Effect of glutamine on water and sodium absorption in human jejunum at baseline and during PGE1-induced secretion. J Appl Physiol. 98(6): 2163-8. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/15661841?dopt=Abstract (accessed 5/9/2012).
Coëffier, M., et al. 2003. Enteral glutamine stimulates protein synthesis and decreases ubiquitin mRNA level in human gut mucosa. Am J Physiol Gastrointest Liver Physiol. 285(2): G266-73. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/12702496?dopt=Abstract (accessed 5/9/2012).
Dai, Z. L., et al. 2012. L-Glutamine regulates amino acid utilization by intestinal bacteria. Amino Acids., 2012 Mar 24 Epub. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/22451274 (accessed 5/8/2012).
Hond, D. E., et al. 1999. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn’s disease. JPEN J Parenter Enteral Nutr., 23(1): 7-11. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/9888411.1 (accessed 5/9/2012).
Jian, Z. M., et al. 1999. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients. JPEN J Parenter Enteral Nutr., 26(5 Suppl): S62-6. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/10483898?dopt=Abstract (accessed 5/9/2012).
Kennedy, D., et al. 2007. Cost Effectiveness of Natural Health Products: A Systematic Review of Randomized Clinical Trials. Evid Based Complement Alternat Med., 6(3): 297-304. doi: 10.1093/ecam/nem167. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722206/?tool=pmcentrez (accessed 5/7/2012).
Larson, S., et al. 2007. Molecular Mechanisms Contributing to Glutamine-Mediated Intestinal Cell Survival. Am J Physiol Gastrointest Liver Physiol., 293(6): G1262 – G1271. doi: 10.1152/ajpgi.00254.2007. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432018/?tool=pmcentrez (accessed 5/7/2012).
May, P. E., et al. 2002. Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-mehtylbutyrate, arginine, and glutamine. Am J Surg., 183(4): 471-9. URl (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/11975938?dopt=Abstract (accessed 5/9/2012).
Mok, E. and Hankard, R. 2011. Glutamine Supplementation in Sick Children: Is It Beneficial? J Nutr Metab. 2001: 617597. doi: 10.1155/2011/617597. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228321/?tool=pmcentrez (accessed 5/7/2012).
Motoki, T., et al. 2011. Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium. World J Gastroenterol., 17(6): 717-726. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042649/?tool=pmcentrez (accessed 5/7/2012).
Niihara, Y., et al. 2005. L-Glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cells. BMC Blood Disord., 5:4. doi: 10.1186/1471-2326-5-4. URL (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1198219/?tool=pmcentrez (accessed 5/8/2012).
Nose, K., et al. 2010. Glutamine Prevents Total Parenteral Nutrition-Associated Changes to Intraepithelial Lymphocyte Phenotype and Function: A Potential Mechanism for the Preservation of Epithelial Barrier Function. J Interferon Cytokine Res., 30(2): 67-79. doi: 10.1089/jir.2009.0046. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830305/?tool=pmcentrez (accessed 5/7/2012).
Noyer, C. M., et al. 1998. A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS. Am J Gastroenterol., 93(6): 972-5. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/9647031?dopt=Abstract (accessed 5/9/2012).
Sakiyama, T., et al. 2009. Glutamine increases autophagy under basal and stressed conditions in intestinal epithelial cells. Gastroenterology. 136(3): 924-932. doi: 10.1053/j.gastro.2008.12.002. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673957/?tool=pmcentrez (accessed 5/7/2012).
Van Der Hulst, R. R., et al. 1997. Glutamine and intestinal immune cells in humans. JPEN J Parenter Enteral Nutr., 21(6): 310-5. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/9406126?dopt=Abstract (accessed 5/9/2012).
Van Der Hulst, R. R., et al. 1996. The effect of glutamine administration on intestinal glutamine content. J Surg Res., 61(1): 30-4. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/8769938?dopt=Abstract (accessed 5/9/2012)/
Van Der Hulst, R. R., et al. 1993. Glutamine and the preservation of gut integrity. Lancet, 341(8857): 1363-5. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/8098788?dopt=Abstract (accessed 5/9/2012).
Yalçin, S. S., et al. 2004. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. J Pedatr Gastroenterol Nutr., 38(5):494-51. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/15097437?dopt=Abstract (accessed 5/9/2012).