화합물 181 - E 1 LC / MS ESI 495 ( M + H ) +. 1 H NMR ( 500 MHz , MeOD ) δ 7 . 56 ( dd , J = 7 . 7 , 1 . 4 Hz , 1 H ) , 7 . 45 ? 7 . 36 ( m , 1 H ) , 7 . 12 ( dd , J = 18 . 8 , 7 . 8 Hz , 2 H ) , 7 . 00 ( t , J = 7 . 5 Hz , 1 H ) , 6 . 38 ( d , J = 7 . 3 Hz , 1 H ) , 4 . 96 ( s , 1 H ) , 4 . 75 ( dt , J = 12 . 1 , 6 . 0 Hz , 1 H ) , 3 . 71 ( s , 1 H ) , 3 . 45 ? 3 . 35 ( m , 2 H ) , 3 . 33 ? 3 . 25 ( m , 2 H ) , 3 . 19 ( t , J = 6 . 9 Hz , 2 H ) , 2 . 96 ( s , 2 H ) , 2 . 70 ( t , J = 6 . 2 Hz , 2 H ) , 2 . 57 ? 2 . 49 ( m , 2 H ) , 2 . 44 ( d , J = 4 . 6 Hz , 1 H ) , 1 . 95 ( d , J = 4 . 7 Hz , 4 H ) , 1 . 91 ? 1 . 70 ( m , 4 H ) , 1 . 42 ( d , J = 6 . 0 Hz , 6 H ) . 키 랄 SFC F ( 45 % MeOH ) : ee 97 %, Rt = 5 . 83 분 .