< 110 > MedImmune Ltd Cohen , Suzanne Dobson , Claire L Eriksson , Per - Olof Lane , Deborah L Von Wachenfeldt , Karin < 120 > Binding members for interleukin - 4 receptor alpha ( IL - 4 Ra ) - 173 < 130 > 103173 - 1 L US < 140 > < 141 > < 150 > US 61 / 015 , 869 < 151 > 2007 - 12 - 21 < 160 > 461 < 170 > Cambridge Antibody Technology patent software version 1 . 0 < 210 > 1 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 1 < 400 > 1 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggcttg actactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 2 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 1 < 400 > 2 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Leu Asp Tyr Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 3 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 1 < 400 > 3 Ser Tyr Tyr Met His 5 < 210 > 4 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 1 < 400 > 4 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 5 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 1 < 400 > 5 Gly Lys Trp Trp Leu Asp Tyr 5 < 210 > 6 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 1 < 400 > 6 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcctgag tgccaattat 300 gtcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 7 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 1 < 400 > 7 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 85 90 95 Ser Ala Asn Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 8 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 1 < 400 > 8 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 9 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 1 < 400 > 9 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 10 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 1 < 400 > 10 Gly Thr Trp Asp Thr Ser Leu Ser Ala Asn Tyr Val 5 10 < 210 > 11 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 2 < 400 > 11 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggctgt acaactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 12 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 2 < 400 > 12 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Leu Tyr Asn Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 13 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 2 < 400 > 13 Ser Tyr Tyr Met His 5 < 210 > 14 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 2 < 400 > 14 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 15 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 2 < 400 > 15 Gly Lys Trp Trp Leu Tyr Asn 5 < 210 > 16 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 2 < 400 > 16 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagccagcc cccgaacccc 300 ctcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 17 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 2 < 400 > 17 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Gln 85 90 95 Pro Pro Asn Pro Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 18 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 2 < 400 > 18 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 19 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 2 < 400 > 19 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 20 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 2 < 400 > 20 Gly Thr Trp Asp Thr Ser Gln Pro Pro Asn Pro Leu 5 10 < 210 > 21 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 3 < 400 > 21 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 ttgttgaaga acccctgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 22 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 3 < 400 > 22 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Leu Leu Lys Asn Pro Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 23 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 3 < 400 > 23 Ser Tyr Tyr Met His 5 < 210 > 24 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 3 < 400 > 24 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 25 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 3 < 400 > 25 Gly Lys Leu Leu Lys Asn Pro 5 < 210 > 26 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 3 < 400 > 26 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatggttcg gcacccccgc gagcaattat 300 gtcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 27 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 3 < 400 > 27 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Phe Gly Thr Pro 85 90 95 Ala Ser Asn Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 28 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 3 < 400 > 28 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 29 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 3 < 400 > 29 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 30 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 3 < 400 > 30 Gly Thr Trp Phe Gly Thr Pro Ala Ser Asn Tyr Val 5 10 < 210 > 31 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 4 < 400 > 31 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggctgt acaactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 32 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 4 < 400 > 32 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Leu Tyr Asn Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 33 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 4 < 400 > 33 Ser Tyr Tyr Met His 5 < 210 > 34 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 4 < 400 > 34 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 35 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 4 < 400 > 35 Gly Lys Trp Trp Leu Tyr Asn 5 < 210 > 36 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 4 < 400 > 36 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcagccc cccccagccg 300 atcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 37 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 4 < 400 > 37 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Ser 85 90 95 Pro Pro Gln Pro Ile Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 38 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 4 < 400 > 38 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 39 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 4 < 400 > 39 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 40 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 4 < 400 > 40 Gly Thr Trp Asp Thr Ser Ser Pro Pro Gln Pro Ile 5 10 < 210 > 41 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 5 < 400 > 41 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggttgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 42 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 5 < 400 > 42 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Leu Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 43 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 5 < 400 > 43 Ser Tyr Tyr Met His 5 < 210 > 44 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 5 < 400 > 44 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 45 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 5 < 400 > 45 Gly Lys Trp Trp Leu Tyr Asp 5 < 210 > 46 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 5 < 400 > 46 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcagccc cccccagccg 300 atcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 47 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 5 < 400 > 47 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Ser 85 90 95 Pro Pro Gln Pro Ile Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 48 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 5 < 400 > 48 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 49 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 5 < 400 > 49 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 50 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 5 < 400 > 50 Gly Thr Trp Asp Thr Ser Ser Pro Pro Gln Pro Ile 5 10 < 210 > 51 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 6 < 400 > 51 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 52 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 6 < 400 > 52 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 53 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 6 < 400 > 53 Ser Tyr Tyr Met His 5 < 210 > 54 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 6 < 400 > 54 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 55 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 6 < 400 > 55 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 56 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 6 < 400 > 56 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacgac ctaccacccc 300 atcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 57 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 6 < 400 > 57 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Thr Tyr His Pro Ile Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 58 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 6 < 400 > 58 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 59 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 6 < 400 > 59 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 60 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 6 < 400 > 60 Gly Thr Trp Asp Thr Ser Thr Thr Tyr His Pro Ile 5 10 < 210 > 61 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 7 < 400 > 61 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggtggc agtactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 62 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 7 < 400 > 62 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Trp Gln Tyr Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 63 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 7 < 400 > 63 Ser Tyr Tyr Met His 5 < 210 > 64 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 7 < 400 > 64 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 65 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 7 < 400 > 65 Gly Lys Trp Trp Trp Gln Tyr 5 < 210 > 66 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 7 < 400 > 66 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcagccc cccccagccg 300 atcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 67 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 7 < 400 > 67 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Ser 85 90 95 Pro Pro Gln Pro Ile Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 68 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 7 < 400 > 68 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 69 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 7 < 400 > 69 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 70 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 7 < 400 > 70 Gly Thr Trp Asp Thr Ser Ser Pro Pro Gln Pro Ile 5 10 < 210 > 71 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 8 < 400 > 71 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggtggc agtactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 72 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 8 < 400 > 72 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Trp Gln Tyr Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 73 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 8 < 400 > 73 Ser Tyr Tyr Met His 5 < 210 > 74 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 8 < 400 > 74 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 75 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 8 < 400 > 75 Gly Lys Trp Trp Trp Gln Tyr 5 < 210 > 76 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 8 < 400 > 76 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacgac ctaccacccc 300 atcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 77 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 8 < 400 > 77 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Thr Tyr His Pro Ile Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 78 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 8 < 400 > 78 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 79 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 8 < 400 > 79 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 80 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 8 < 400 > 80 Gly Thr Trp Asp Thr Ser Thr Thr Tyr His Pro Ile 5 10 < 210 > 81 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 9 < 400 > 81 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggctgt acaactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 82 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 9 < 400 > 82 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Leu Tyr Asn Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 83 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 9 < 400 > 83 Ser Tyr Tyr Met His 5 < 210 > 84 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 9 < 400 > 84 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 85 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 9 < 400 > 85 Gly Lys Trp Trp Leu Tyr Asn 5 < 210 > 86 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 9 < 400 > 86 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacgac gatgtacccg 300 ttgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 87 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 9 < 400 > 87 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Thr Met Tyr Pro Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 88 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 9 < 400 > 88 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 89 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 9 < 400 > 89 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 90 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 9 < 400 > 90 Gly Thr Trp Asp Thr Ser Thr Thr Met Tyr Pro Leu 5 10 < 210 > 91 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 10 < 400 > 91 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggctct acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 92 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 10 < 400 > 92 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Leu Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 93 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 10 < 400 > 93 Ser Tyr Tyr Met His 5 < 210 > 94 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 10 < 400 > 94 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 95 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 10 < 400 > 95 Gly Lys Trp Trp Leu Tyr Asp 5 < 210 > 96 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 10 < 400 > 96 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcaccgt cctcaccccc 300 atcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 97 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 10 < 400 > 97 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Leu Thr Pro Ile Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 98 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 10 < 400 > 98 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 99 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 10 < 400 > 99 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 100 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 10 < 400 > 100 Gly Thr Trp Asp Thr Ser Thr Val Leu Thr Pro Ile 5 10 < 210 > 101 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 11 < 400 > 101 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggttct acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 102 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 11 < 400 > 102 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Phe Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 103 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 11 < 400 > 103 Ser Tyr Tyr Met His 5 < 210 > 104 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 11 < 400 > 104 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 105 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 11 < 400 > 105 Gly Lys Trp Trp Phe Tyr Asp 5 < 210 > 106 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 11 < 400 > 106 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagccccag catgatcccg 300 ctcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 107 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 11 < 400 > 107 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Pro 85 90 95 Ser Met Ile Pro Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 108 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 11 < 400 > 108 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 109 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 11 < 400 > 109 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 110 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 11 < 400 > 110 Gly Thr Trp Asp Thr Ser Pro Ser Met Ile Pro Leu 5 10 < 210 > 111 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 12 < 400 > 111 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggttct acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 112 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 12 < 400 > 112 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Phe Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 113 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 12 < 400 > 113 Ser Tyr Tyr Met His 5 < 210 > 114 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 12 < 400 > 114 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 115 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 12 < 400 > 115 Gly Lys Trp Trp Phe Tyr Asp 5 < 210 > 116 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 12 < 400 > 116 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacgac gatgtacccg 300 ttgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 117 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 12 < 400 > 117 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Thr Met Tyr Pro Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 118 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 12 < 400 > 118 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 119 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 12 < 400 > 119 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 120 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 12 < 400 > 120 Gly Thr Trp Asp Thr Ser Thr Thr Met Tyr Pro Leu 5 10 < 210 > 121 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 13 < 400 > 121 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tggtggctct acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 122 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 13 < 400 > 122 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Leu Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 123 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 13 < 400 > 123 Ser Tyr Tyr Met His 5 < 210 > 124 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 13 < 400 > 124 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 125 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 13 < 400 > 125 Gly Lys Trp Trp Leu Tyr Asp 5 < 210 > 126 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 13 < 400 > 126 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacgac cttgcagccg 300 ctgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 127 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 13 < 400 > 127 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Thr Leu Gln Pro Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 128 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 13 < 400 > 128 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 129 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 13 < 400 > 129 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 130 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 13 < 400 > 130 Gly Thr Trp Asp Thr Ser Thr Thr Leu Gln Pro Leu 5 10 < 210 > 131 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 14 < 400 > 131 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggctgt acaactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 132 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 14 < 400 > 132 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Leu Tyr Asn Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 133 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 14 < 400 > 133 Ser Tyr Tyr Met His 5 < 210 > 134 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 14 < 400 > 134 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 135 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 14 < 400 > 135 Gly Lys Trp Trp Leu Tyr Asn 5 < 210 > 136 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 14 < 400 > 136 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcccccc gaccaagccc 300 ttgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 137 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 14 < 400 > 137 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Pro 85 90 95 Pro Thr Lys Pro Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 138 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 14 < 400 > 138 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 139 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 14 < 400 > 139 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 140 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 14 < 400 > 140 Gly Thr Trp Asp Thr Ser Pro Pro Thr Lys Pro Leu 5 10 < 210 > 141 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 15 < 400 > 141 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggctgt acaactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 142 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 15 < 400 > 142 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Leu Tyr Asn Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 143 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 15 < 400 > 143 Ser Tyr Tyr Met His 5 < 210 > 144 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 15 < 400 > 144 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 145 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 15 < 400 > 145 Gly Lys Trp Trp Leu Tyr Asn 5 < 210 > 146 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 15 < 400 > 146 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcaccca ccggcatccc 300 ctcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 147 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 15 < 400 > 147 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 His Arg His Pro Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 148 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 15 < 400 > 148 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 149 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 15 < 400 > 149 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 150 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 15 < 400 > 150 Gly Thr Trp Asp Thr Ser Thr His Arg His Pro Leu 5 10 < 210 > 151 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 16 < 400 > 151 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggctgt acaactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 152 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 16 < 400 > 152 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Leu Tyr Asn Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 153 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 16 < 400 > 153 Ser Tyr Tyr Met His 5 < 210 > 154 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 16 < 400 > 154 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 155 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 16 < 400 > 155 Gly Lys Trp Trp Leu Tyr Asn 5 < 210 > 156 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 16 < 400 > 156 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacgac ctaccacccc 300 atcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 157 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 16 < 400 > 157 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Thr Tyr His Pro Ile Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 158 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 16 < 400 > 158 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 159 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 16 < 400 > 159 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 160 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 16 < 400 > 160 Gly Thr Trp Asp Thr Ser Thr Thr Tyr His Pro Ile 5 10 < 210 > 161 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 17 < 400 > 161 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggtggc agcactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 162 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 17 < 400 > 162 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Trp Gln His Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 163 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 17 < 400 > 163 Ser Tyr Tyr Met His 5 < 210 > 164 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 17 < 400 > 164 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 165 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 17 < 400 > 165 Gly Lys Trp Trp Trp Gln His 5 < 210 > 166 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 17 < 400 > 166 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcccggt ggacaggccg 300 atcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 167 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 17 < 400 > 167 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Pro 85 90 95 Val Asp Arg Pro Ile Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 168 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 17 < 400 > 168 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 169 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 17 < 400 > 169 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 170 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 17 < 400 > 170 Gly Thr Trp Asp Thr Ser Pro Val Asp Arg Pro Ile 5 10 < 210 > 171 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 18 < 400 > 171 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggtggc agcactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 172 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 18 < 400 > 172 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Trp Gln His Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 173 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 18 < 400 > 173 Ser Tyr Tyr Met His 5 < 210 > 174 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 18 < 400 > 174 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 175 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 18 < 400 > 175 Gly Lys Trp Trp Trp Gln His 5 < 210 > 176 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 18 < 400 > 176 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcaccac cccgatgccc 300 gtcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 177 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 18 < 400 > 177 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Thr Pro Met Pro Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 178 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 18 < 400 > 178 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 179 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 18 < 400 > 179 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 180 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 18 < 400 > 180 Gly Thr Trp Asp Thr Ser Thr Thr Pro Met Pro Val 5 10 < 210 > 181 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 19 < 400 > 181 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaaa 300 tggtggtggc agcactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 182 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 19 < 400 > 182 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Trp Trp Trp Gln His Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 183 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 19 < 400 > 183 Ser Tyr Tyr Met His 5 < 210 > 184 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 19 < 400 > 184 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 185 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 19 < 400 > 185 Gly Lys Trp Trp Trp Gln His 5 < 210 > 186 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 19 < 400 > 186 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacgac ctaccacccc 300 atcttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 187 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 19 < 400 > 187 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Thr Tyr His Pro Ile Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 188 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 19 < 400 > 188 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 189 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 19 < 400 > 189 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 190 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 19 < 400 > 190 Gly Thr Trp Asp Thr Ser Thr Thr Tyr His Pro Ile 5 10 < 210 > 191 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 20 < 400 > 191 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 192 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 20 < 400 > 192 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 193 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 20 < 400 > 193 Ser Tyr Tyr Met His 5 < 210 > 194 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 20 < 400 > 194 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 195 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 20 < 400 > 195 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 196 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 20 < 400 > 196 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 197 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 20 < 400 > 197 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 198 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 20 < 400 > 198 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 199 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 20 < 400 > 199 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 200 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 20 < 400 > 200 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 201 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 21 < 400 > 201 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatggggata atcaacccta gtggtggtag cgcaagctac 180 gcgcagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 202 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 21 < 400 > 202 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Ala Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 203 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 21 < 400 > 203 Ser Tyr Tyr Met His 5 < 210 > 204 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 21 < 400 > 204 Ile Ile Asn Pro Ser Gly Gly Ser Ala Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 205 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 21 < 400 > 205 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 206 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 21 < 400 > 206 cagtctgtgt tgacgcagcc gccctcggtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgttta tttctgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 207 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 21 < 400 > 207 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Val Tyr Phe Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 208 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 21 < 400 > 208 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 209 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 21 < 400 > 209 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 210 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 21 < 400 > 210 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 211 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 22 < 400 > 211 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ccggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 212 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 22 < 400 > 212 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 213 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 22 < 400 > 213 Ser Tyr Tyr Met His 5 < 210 > 214 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 22 < 400 > 214 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 215 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 22 < 400 > 215 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 216 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 22 < 400 > 216 cagcccgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta tttctgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 217 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 22 < 400 > 217 Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Phe Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 218 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 22 < 400 > 218 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 219 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 22 < 400 > 219 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 220 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 22 < 400 > 220 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 221 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 23 < 400 > 221 caggtccagc tggtgcagtc tggggctgag gtgaggaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cccgggcaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcgcagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 222 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 23 < 400 > 222 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 223 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 23 < 400 > 223 Ser Tyr Tyr Met His 5 < 210 > 224 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 23 < 400 > 224 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 225 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 23 < 400 > 225 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 226 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 23 < 400 > 226 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aataattatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccccc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 227 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 23 < 400 > 227 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Pro Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 228 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 23 < 400 > 228 Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 5 10 < 210 > 229 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 23 < 400 > 229 Asp Asn Asn Lys Arg Pro Pro 5 < 210 > 230 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 23 < 400 > 230 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 231 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 24 < 400 > 231 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gaggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 232 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 < 400 > 232 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 233 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 < 400 > 233 Ser Tyr Tyr Met His 5 < 210 > 234 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 < 400 > 234 Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 235 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 < 400 > 235 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 236 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 24 < 400 > 236 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta tttctgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 237 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 < 400 > 237 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Phe Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 238 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 < 400 > 238 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 239 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 < 400 > 239 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 240 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 < 400 > 240 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 241 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 25 < 400 > 241 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gaggtggtag cgcaagctac 180 gcacagaagt tccagggcag agtctccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag gtctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 242 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 25 < 400 > 242 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Arg Gly Gly Ser Ala Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Ser Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 243 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 25 < 400 > 243 Ser Tyr Tyr Met His 5 < 210 > 244 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 25 < 400 > 244 Ile Ile Asn Pro Arg Gly Gly Ser Ala Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 245 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 25 < 400 > 245 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 246 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 25 < 400 > 246 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc cgggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg acagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggtta ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 247 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 25 < 400 > 247 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Thr Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Val Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 248 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 25 < 400 > 248 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 249 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 25 < 400 > 249 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 250 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 25 < 400 > 250 Gly Thr Trp Val Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 251 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 26 < 400 > 251 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 252 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 26 < 400 > 252 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 253 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 26 < 400 > 253 Ser Tyr Tyr Met His 5 < 210 > 254 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 26 < 400 > 254 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 255 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 26 < 400 > 255 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 256 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 26 < 400 > 256 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta tttctgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 257 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 26 < 400 > 257 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Phe Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 258 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 26 < 400 > 258 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 259 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 26 < 400 > 259 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 260 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 26 < 400 > 260 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 261 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 27 < 400 > 261 caggtccagc tggtgcagtc tggggctgag gtgaggaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agttaccatg accagggaca cgtccacgag cacggtctac 240 atggagctga gcagcctgag acctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc caggtcaccg tctcgagt 348 < 210 > 262 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 27 < 400 > 262 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Gln Val 100 105 110 Thr Val Ser Ser 115 < 210 > 263 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 27 < 400 > 263 Ser Tyr Tyr Met His 5 < 210 > 264 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 27 < 400 > 264 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 265 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 27 < 400 > 265 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 266 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 27 < 400 > 266 cagtctgtgt tgacgcagcc gcccttagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcgactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 267 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 27 < 400 > 267 Gln Ser Val Leu Thr Gln Pro Pro Leu Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Arg Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 268 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 27 < 400 > 268 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 269 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 27 < 400 > 269 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 270 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 27 < 400 > 270 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 271 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 28 < 400 > 271 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaagac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caacggcacc ctggtcaccg tctcgagt 348 < 210 > 272 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 28 < 400 > 272 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Asn Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 273 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 28 < 400 > 273 Ser Tyr Tyr Met His 5 < 210 > 274 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 28 < 400 > 274 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 275 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 28 < 400 > 275 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 276 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 28 < 400 > 276 ctgcctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc cagcattggg aatagttatg tatcctggta ccagcaactc 120 ccaggagcag cccccaaact cctcatttac gacaacaata agcgaccctc agggattcct 180 gaccgattct ctggcttcag gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcccggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 277 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 28 < 400 > 277 Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Ser Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Phe Arg Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Pro 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 278 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 28 < 400 > 278 Ser Gly Gly Ser Ser Ser Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 279 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 28 < 400 > 279 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 280 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 28 < 400 > 280 Gly Thr Trp Asp Thr Ser Pro Val Trp Glu Trp Pro 5 10 < 210 > 281 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 29 < 400 > 281 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc cgggtcaccg tctcgagt 348 < 210 > 282 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 29 < 400 > 282 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Arg Val 100 105 110 Thr Val Ser Ser 115 < 210 > 283 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 29 < 400 > 283 Ser Tyr Tyr Met His 5 < 210 > 284 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 29 < 400 > 284 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 285 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 29 < 400 > 285 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 286 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 29 < 400 > 286 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcccggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 287 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 29 < 400 > 287 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Pro 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 288 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 29 < 400 > 288 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 289 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 29 < 400 > 289 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 290 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 29 < 400 > 290 Gly Thr Trp Asp Thr Ser Pro Val Trp Glu Trp Pro 5 10 < 210 > 291 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 30 < 400 > 291 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatggggata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 292 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 30 < 400 > 292 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 293 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 30 < 400 > 293 Ser Tyr Tyr Met His 5 < 210 > 294 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 30 < 400 > 294 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 295 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 30 < 400 > 295 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 296 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 30 < 400 > 296 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg ggggcagctc caacattggg aatagttatg tatcctggta ccagcgactc 120 ccaggagcag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 297 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 30 < 400 > 297 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Arg Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 298 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 30 < 400 > 298 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 299 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 30 < 400 > 299 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 300 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 30 < 400 > 300 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 301 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 31 < 400 > 301 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 302 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 31 < 400 > 302 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 303 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 31 < 400 > 303 Ser Tyr Tyr Met His 5 < 210 > 304 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 31 < 400 > 304 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 305 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 31 < 400 > 305 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 306 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 31 < 400 > 306 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc cagcattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggcta ccagcccggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 307 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 31 < 400 > 307 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Ser Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Ala Thr Ser Pro 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 308 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 31 < 400 > 308 Ser Gly Gly Ser Ser Ser Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 309 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 31 < 400 > 309 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 310 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 31 < 400 > 310 Gly Thr Trp Ala Thr Ser Pro Val Trp Glu Trp Pro 5 10 < 210 > 311 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 32 < 400 > 311 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 312 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 32 < 400 > 312 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 313 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 32 < 400 > 313 Ser Tyr Tyr Met His 5 < 210 > 314 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 32 < 400 > 314 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 315 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 32 < 400 > 315 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 316 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 32 < 400 > 316 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta tttctgcgga acatgggata ccagcacggc gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 317 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 32 < 400 > 317 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Phe Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Ala Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 318 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 32 < 400 > 318 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 319 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 32 < 400 > 319 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 320 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 32 < 400 > 320 Gly Thr Trp Asp Thr Ser Thr Ala Trp Glu Trp Pro 5 10 < 210 > 321 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 33 < 400 > 321 caggtccagc tggtgcagtc tggggctgag gagaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cactagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 322 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 33 < 400 > 322 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Glu Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 323 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 33 < 400 > 323 Ser Tyr Tyr Met His 5 < 210 > 324 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 33 < 400 > 324 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 325 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 33 < 400 > 325 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 326 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 33 < 400 > 326 cagtctgcgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 cctggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta tttctgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ccgggaccaa gctgaccgtc cta 333 < 210 > 327 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 33 < 400 > 327 Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Phe Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 328 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 33 < 400 > 328 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 329 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 33 < 400 > 329 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 330 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 33 < 400 > 330 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 331 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 34 < 400 > 331 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtctccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 332 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 34 < 400 > 332 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Ser Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 333 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 34 < 400 > 333 Ser Tyr Tyr Met His 5 < 210 > 334 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 34 < 400 > 334 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 335 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 34 < 400 > 335 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 336 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 34 < 400 > 336 cagtctgtgt tgacgcagcc gccctcagtg tccgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tgtcctggta ccagcaactc 120 ccaggaacgg cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta tttctgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 337 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 34 < 400 > 337 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Phe Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 338 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 34 < 400 > 338 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 339 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 34 < 400 > 339 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 340 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 34 < 400 > 340 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 341 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 35 < 400 > 341 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 342 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 35 < 400 > 342 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 343 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 35 < 400 > 343 Ser Tyr Tyr Met His 5 < 210 > 344 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 35 < 400 > 344 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 345 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 35 < 400 > 345 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 346 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 35 < 400 > 346 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcccggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 347 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 35 < 400 > 347 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Pro 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 348 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 35 < 400 > 348 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 349 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 35 < 400 > 349 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 350 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 35 < 400 > 350 Gly Thr Trp Asp Thr Ser Pro Val Trp Glu Trp Pro 5 10 < 210 > 351 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 36 < 400 > 351 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactaca tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cgcaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 352 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 36 < 400 > 352 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Ala Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 353 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 36 < 400 > 353 Ser Tyr Tyr Met His 5 < 210 > 354 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 36 < 400 > 354 Ile Ile Asn Pro Ser Gly Gly Ser Ala Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 355 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 36 < 400 > 355 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 356 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 36 < 400 > 356 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggatt ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 357 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 36 < 400 > 357 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 358 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 36 < 400 > 358 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 359 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 36 < 400 > 359 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 360 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 36 < 400 > 360 Gly Thr Trp Asp Ser Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 361 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 37 < 400 > 361 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gaggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcgccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag acctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 362 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 < 400 > 362 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Ala Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 363 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 < 400 > 363 Ser Tyr Tyr Met His 5 < 210 > 364 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 < 400 > 364 Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 365 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 < 400 > 365 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 366 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 37 < 400 > 366 cagtctgtgt tgacgcagcc gccctcagtg tcagcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcggctc cagcattggg aatagctatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatctac gacaataata agcgaccctc aggggttcct 180 gaccgattct ctggctccaa gtctggcacg tcggccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcccggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 367 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 < 400 > 367 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Gly Ser Ser Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Pro 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 368 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 < 400 > 368 Ser Gly Gly Gly Ser Ser Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 369 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 < 400 > 369 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 370 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 < 400 > 370 Gly Thr Trp Asp Thr Ser Pro Val Trp Glu Trp Pro 5 10 < 210 > 371 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 38 < 400 > 371 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cgcaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 372 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 38 < 400 > 372 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Ala Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 373 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 38 < 400 > 373 Ser Tyr Tyr Met His 5 < 210 > 374 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 38 < 400 > 374 Ile Ile Asn Pro Ser Gly Gly Ser Ala Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 375 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 38 < 400 > 375 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 376 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 38 < 400 > 376 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta tttctgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 377 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 38 < 400 > 377 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Phe Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 378 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 38 < 400 > 378 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 379 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 38 < 400 > 379 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 380 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 38 < 400 > 380 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 381 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 39 < 400 > 381 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta ggggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 382 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 39 < 400 > 382 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 383 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 39 < 400 > 383 Ser Tyr Tyr Met His 5 < 210 > 384 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 39 < 400 > 384 Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 385 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 39 < 400 > 385 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 386 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 39 < 400 > 386 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacggc gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 387 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 39 < 400 > 387 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Ala Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 388 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 39 < 400 > 388 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 389 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 39 < 400 > 389 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 390 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 39 < 400 > 390 Gly Thr Trp Asp Thr Ser Thr Ala Trp Glu Trp Pro 5 10 < 210 > 391 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 40 < 400 > 391 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 392 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 40 < 400 > 392 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 393 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 40 < 400 > 393 Ser Tyr Tyr Met His 5 < 210 > 394 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 40 < 400 > 394 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 395 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 40 < 400 > 395 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 396 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 40 < 400 > 396 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggatt ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 397 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 40 < 400 > 397 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 398 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 40 < 400 > 398 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 399 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 40 < 400 > 399 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 400 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 40 < 400 > 400 Gly Thr Trp Asp Ser Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 401 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 41 < 400 > 401 caggtccagc tggtgcagtc tggggctgag gtgaggaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggc gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag acctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgggt 348 < 210 > 402 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 41 < 400 > 402 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Gly 115 < 210 > 403 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 41 < 400 > 403 Ser Tyr Tyr Met His 5 < 210 > 404 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 41 < 400 > 404 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 405 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 41 < 400 > 405 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 406 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 41 < 400 > 406 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagcac caacattggg aatagttatg tatcctggta ccagcgactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccccc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 407 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 41 < 400 > 407 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Thr Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Arg Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Pro Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 408 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 41 < 400 > 408 Ser Gly Gly Ser Thr Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 409 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 41 < 400 > 409 Asp Asn Asn Lys Arg Pro Pro 5 < 210 > 410 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 41 < 400 > 410 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 411 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 42 < 400 > 411 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgcctttacc agctactata tgcactgggc gcgacaggcc 120 cctggacagg ggcttgagtg ggtgggaata atcaacccta gcggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctggggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 412 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 42 < 400 > 412 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Gly Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 413 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 42 < 400 > 413 Ser Tyr Tyr Met His 5 < 210 > 414 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 42 < 400 > 414 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 415 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 42 < 400 > 415 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 416 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 42 < 400 > 416 caggctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcgactc 120 ccaggagcag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacggg gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 417 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 42 < 400 > 417 Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Arg Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Gly Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 418 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 42 < 400 > 418 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 419 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 42 < 400 > 419 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 420 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 42 < 400 > 420 Gly Thr Trp Asp Thr Ser Thr Gly Trp Glu Trp Pro 5 10 < 210 > 421 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 24 PGL < 400 > 421 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gaggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 422 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 PGL < 400 > 422 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 423 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 PGL < 400 > 423 Ser Tyr Tyr Met His 5 < 210 > 424 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 PGL < 400 > 424 Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 425 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 PGL < 400 > 425 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 426 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 24 PGL < 400 > 426 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag 240 actggggacg aggccgatta tttctgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 427 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 PGL < 400 > 427 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Phe Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 428 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 PGL < 400 > 428 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 429 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 PGL < 400 > 429 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 430 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 PGL < 400 > 430 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 431 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 24 GL < 400 > 431 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gaggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 432 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 GL < 400 > 432 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 433 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 GL < 400 > 433 Ser Tyr Tyr Met His 5 < 210 > 434 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 GL < 400 > 434 Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 435 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 GL < 400 > 435 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 436 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 24 GL < 400 > 436 cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcagctc caacattggg aatagttatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatttac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcacggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 437 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 GL < 400 > 437 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Thr 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 438 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 GL < 400 > 438 Ser Gly Gly Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 439 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 GL < 400 > 439 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 440 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 24 GL < 400 > 440 Gly Thr Trp Asp Thr Ser Thr Val Trp Glu Trp Pro 5 10 < 210 > 441 < 211 > 348 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 37 GL < 400 > 441 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata cgccttcacc agctactata tgcactgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcaacccta gaggtggtag cacaagctac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggaaag 300 tactggatgt acgactgggg caaaggcacc ctggtcaccg tctcgagt 348 < 210 > 442 < 211 > 116 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 GL < 400 > 442 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Tyr Trp Met Tyr Asp Trp Gly Lys Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 443 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 GL < 400 > 443 Ser Tyr Tyr Met His 5 < 210 > 444 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 GL < 400 > 444 Ile Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 5 10 15 Gly < 210 > 445 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 GL < 400 > 445 Gly Lys Tyr Trp Met Tyr Asp 5 < 210 > 446 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Antibody 37 GL < 400 > 446 cagtctgtgt tgacgcagcc gccctcagtg tcagcggccc caggacagaa ggtcaccatc 60 tcctgctctg gaggcggctc cagcattggg aatagctatg tatcctggta ccagcaactc 120 ccaggaacag cccccaaact cctcatctac gacaataata agcgaccctc agggattcct 180 gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag 240 actggggacg aggccgatta ttactgcgga acatgggata ccagcccggt gtgggagtgg 300 ccgttcggaa ctgggaccaa gctgaccgtc cta 333 < 210 > 447 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 GL < 400 > 447 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Gly Ser Ser Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Pro 85 90 95 Val Trp Glu Trp Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 448 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 GL < 400 > 448 Ser Gly Gly Gly Ser Ser Ile Gly Asn Ser Tyr Val Ser 5 10 < 210 > 449 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 GL < 400 > 449 Asp Asn Asn Lys Arg Pro Ser 5 < 210 > 450 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Antibody 37 GL < 400 > 450 Gly Thr Trp Asp Thr Ser Pro Val Trp Glu Trp Pro 5 10 < 210 > 451 < 211 > 96 < 212 > DNA < 213 > Artificial < 220 > < 223 > Cyno IL 4 R primer 1 < 400 > 451 ggggacaagt ttgtacaaaa aagcaggctt ctttaacttt aagaaggaga tataaccatg 60 gggtggcttt gctctgggct cctgttgcct gtgagc 96 < 210 > 452 < 211 > 63 < 212 > DNA < 213 > Artificial < 220 > < 223 > Cyno IL 4 R primer 2 < 400 > 452 ggggaccact ttgtacaaga aagctgggtc ctgctcgaag ggctccctgt aggagttgta 60 cca 63 < 210 > 453 < 211 > 32 < 212 > DNA < 213 > Artificial < 220 > < 223 > I 75 V oligonucleotide mutation primer < 400 > 453 gaagcccaca cgtgtgccct gagaacaacg ga 32 < 210 > 454 < 211 > 478 < 212 > PRT < 213 > Homo sapiens < 400 > 454 Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 1 5 10 15 Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 20 25 30 Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 35 40 45 Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 50 55 60 Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 65 70 75 80 Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 85 90 95 Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 100 105 110 Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 115 120 125 Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 130 135 140 Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 145 150 155 160 Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 165 170 175 Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 180 185 190 Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 195 200 205 Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 210 215 220 Tyr Arg Glu Pro Phe Asp Pro Ala Phe Leu Tyr Lys Val Val Gly Ala 225 230 235 240 Ala Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 370 375 380 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 420 425 430 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Lys His His His His His His 465 470 475 < 210 > 455 < 211 > 693 < 212 > DNA < 213 > Macaca fascicularis < 220 > < 223 > Cynomolgus monkey IL - 4 Ra cDNA nucleotide < 400 > 455 atggggtggc tttgctctgg gctcctgttg cctgtgagct gcctggtcct gctgcaggtg 60 gcaagctctg ggagcatgaa ggtcctgcag gagcccacct gcgtctccga ctacatgagc 120 atctctacct gtgagtggaa gatgggcggt cccaccaatt gcagcgccga gctccgtctg 180 ttgtaccagc tggtttttca gtcctccgaa acccacacgt gtgtccccga gaacaacggc 240 ggtgtggggt gcgtgtgcca cctgctcatg gatgatgtgg tcagtatgga caactatacg 300 ctggacctgt gggctggaca gcagctgctg tggaagggct ccttcaagcc cagcgagcat 360 gtgaaaccca gggccccagg aaacctcacg gttcacacca atgtctccga cactgtgctg 420 ctgacctgga gcaacccata tccccctgac aattacctgt ataatgatct cacctatgca 480 gtcaacattt ggagtgaaaa cgacccggca tattccagaa tccataacgt gacctaccta 540 aaacccaccc tccgcatccc agccagcacc ctgaagtctg gaatttccta cagggcacgg 600 gtgagggcct gggctcagca ctataacacc acctggagtg agtggagccc cagcaccaag 660 tggtacaact cctacaggga gcccttcgag cag 693 < 210 > 456 < 211 > 1428 < 212 > DNA < 213 > Macaca fascicularis < 220 > < 223 > Cynomolgus monkey IL - 4 Ra / Fc cDNA nucleotide < 400 > 456 atggggtggc tttgctctgg gctcctgttg cctgtgagct gcctggtcct gctgcaggtg 60 gcaagctctg ggagcatgaa ggtcctgcag gagcccacct gcgtctccga ctacatgagc 120 atctctacct gtgagtggaa gatgggcggt cccaccaatt gcagcgccga gctccgtctg 180 ttgtaccagc tggtttttca gtcctccgaa acccacacgt gtgtccccga gaacaacggc 240 ggtgtggggt gcgtgtgcca cctgctcatg gatgatgtgg tcagtatgga caactatacg 300 ctggacctgt gggctggaca gcagctgctg tggaagggct ccttcaagcc cagcgagcat 360 gtgaaaccca gggccccagg aaacctcacg gttcacacca atgtctccga cactgtgctg 420 ctgacctgga gcaacccata tccccctgac aattacctgt ataatgatct cacctatgca 480 gtcaacattt ggagtgaaaa cgacccggca tattccagaa tccataacgt gacctaccta 540 aaacccaccc tccgcatccc agccagcacc ctgaagtctg gaatttccta cagggcacgg 600 gtgagggcct gggctcagca ctataacacc acctggagtg agtggagccc cagcaccaag 660 tggtacaact cctacaggga gcccttcgag caggacccag ctttcttgta caaagtggtt 720 cgattcgagg agcccaaatc tagcgacaaa actcacacat gcccaccgtg cccagcacct 780 gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg 840 atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 900 gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 960 gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1020 tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc 1080 gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc 1140 ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc 1200 tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaaa 1260 accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg 1320 gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 1380 cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga 1428 < 210 > 457 < 211 > 475 < 212 > PRT < 213 > Macaca fascicularis < 220 > < 223 > Cynomolgus monkey IL - 4 Ra / Fc protein < 400 > 457 Met Gly Trp Leu Cys Ser Gly Leu Leu Leu Pro Val Ser Cys Leu Val 1 5 10 15 Leu Leu Gln Val Ala Ser Ser Gly Ser Met Lys Val Leu Gln Glu Pro 20 25 30 Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 35 40 45 Gly Gly Pro Thr Asn Cys Ser Ala Glu Leu Arg Leu Leu Tyr Gln Leu 50 55 60 Val Phe Gln Ser Ser Glu Thr His Thr Cys Val Pro Glu Asn Asn Gly 65 70 75 80 Gly Val Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Met 85 90 95 Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 100 105 110 Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 115 120 125 Leu Thr Val His Thr Asn Val Ser Asp Thr Val Leu Leu Thr Trp Ser 130 135 140 Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn Asp Leu Thr Tyr Ala 145 150 155 160 Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Tyr Ser Arg Ile His Asn 165 170 175 Val Thr Tyr Leu Lys Pro Thr Leu Arg Ile Pro Ala Ser Thr Leu Lys 180 185 190 Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln His Tyr 195 200 205 Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp Tyr Asn Ser 210 215 220 Tyr Arg Glu Pro Phe Glu Gln Asp Pro Ala Phe Leu Tyr Lys Val Val 225 230 235 240 Arg Phe Glu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 245 250 255 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 260 265 270 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 275 280 285 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 290 295 300 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 305 310 315 320 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 325 330 335 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 340 345 350 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 355 360 365 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 370 375 380 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 385 390 395 400 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 405 410 415 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 420 425 430 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 435 440 445 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 450 455 460 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 465 470 475 < 210 > 458 < 211 > 1422 < 212 > DNA < 213 > Homo sapiens < 220 > < 223 > Human I 75 V IL - 4 Ra / Fc cDNA nucleotide < 400 > 458 atggggtggc tttgctctgg gctcctgttc cctgtgagct gcctggtcct gctgcaggtg 60 gcaagctctg ggaacatgaa ggtcttgcag gagcccacct gcgtctccga ctacatgagc 120 atctctactt gcgagtggaa gatgaatggt cccaccaatt gcagcaccga gctccgcctg 180 ttgtaccagc tggtttttct gctctccgaa gcccacacgt gtgtccctga gaacaacgga 240 ggcgcggggt gcgtgtgcca cctgctcatg gatgacgtgg tcagtgcgga taactataca 300 ctggacctgt gggctgggca gcagctgctg tggaagggct ccttcaagcc cagcgagcat 360 gtgaaaccca gggccccagg aaacctgaca gttcacacca atgtctccga cactctgctg 420 ctgacctgga gcaacccgta tccccctgac aattacctgt ataatcatct cacctatgca 480 gtcaacattt ggagtgaaaa cgacccggca gatttcagaa tctataacgt gacctaccta 540 gaaccctccc tccgcatcgc agccagcacc ctgaagtctg ggatttccta cagggcacgg 600 gtgagggcct gggctcagtg ctataacacc acctggagtg agtggagccc cagcaccaag 660 tggcacaact cctacaggga gcccttcgac ccagctttct tgtacaaagt ggttcgattc 720 gaggagccca aatctagcga caaaactcac acatgcccac cgtgcccagc acctgaactc 780 ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 840 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag 900 ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag 960 cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 1020 aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa 1080 accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1140 cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc 1200 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caaaaccacg 1260 cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag 1320 agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac 1380 cactacacgc agaagagcct ctccctgtct ccgggtaaat ga 1422 < 210 > 459 < 211 > 473 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Human I 75 V IL - 4 Ra / Fc protein < 400 > 459 Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 1 5 10 15 Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 20 25 30 Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 35 40 45 Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 50 55 60 Val Phe Leu Leu Ser Glu Ala His Thr Cys Val Pro Glu Asn Asn Gly 65 70 75 80 Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 85 90 95 Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 100 105 110 Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 115 120 125 Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 130 135 140 Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 145 150 155 160 Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 165 170 175 Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 180 185 190 Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 195 200 205 Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 210 215 220 Tyr Arg Glu Pro Phe Asp Pro Ala Phe Leu Tyr Lys Val Val Arg Phe 225 230 235 240 Glu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 245 250 255 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 260 265 270 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 275 280 285 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 290 295 300 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 305 310 315 320 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 325 330 335 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 340 345 350 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 355 360 365 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 370 375 380 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 385 390 395 400 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 405 410 415 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 420 425 430 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 435 440 445 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 450 455 460 Lys Ser Leu Ser Leu Ser Pro Gly Lys 465 470 < 210 > 460 < 211 > 261 < 212 > PRT < 213 > Homo sapiens < 220 > < 223 > Human IL - 4 Ra / HIS tag polypeptide < 400 > 460 Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 1 5 10 15 Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 20 25 30 Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 35 40 45 Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 50 55 60 Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 65 70 75 80 Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 85 90 95 Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 100 105 110 Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 115 120 125 Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 130 135 140 Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 145 150 155 160 Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 165 170 175 Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 180 185 190 Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 195 200 205 Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 210 215 220 Tyr Arg Glu Pro Phe Asn Pro Ala Phe Leu Tyr Lys Val Val Gly Ala 225 230 235 240 Ala Asp Tyr Lys Asp Asp Asp Asp Lys Ala Ala His His His His His 245 250 255 His His His His His 260 < 210 > 461 < 211 > 262 < 212 > PRT < 213 > Mus musculus < 220 > < 223 > Murine IL - 4 Ra / HIS tag polypeptide < 400 > 461 Met Gly Arg Leu Cys Thr Lys Phe Leu Thr Ser Val Gly Cys Leu Ile 1 5 10 15 Leu Leu Leu Val Thr Gly Ser Gly Ser Ile Lys Val Leu Gly Glu Pro 20 25 30 Thr Cys Phe Ser Asp Tyr Ile Arg Thr Ser Thr Cys Glu Trp Phe Leu 35 40 45 Asp Ser Ala Val Asp Cys Ser Ser Gln Leu Cys Leu His Tyr Arg Leu 50 55 60 Met Phe Phe Glu Phe Ser Glu Asn Leu Thr Cys Ile Pro Arg Asn Ser 65 70 75 80 Ala Ser Thr Val Cys Val Cys His Met Glu Met Asn Arg Pro Val Gln 85 90 95 Ser Asp Arg Tyr Gln Met Glu Leu Trp Ala Glu His Arg Gln Leu Trp 100 105 110 Gln Gly Ser Phe Ser Pro Ser Gly Asn Val Lys Pro Leu Ala Pro Asp 115 120 125 Asn Leu Thr Leu His Thr Asn Val Ser Asp Glu Trp Leu Leu Thr Trp 130 135 140 Asn Asn Leu Tyr Pro Ser Asn Asn Leu Leu Tyr Lys Asp Leu Ile Ser 145 150 155 160 Met Val Asn Ile Ser Arg Glu Asp Asn Pro Ala Glu Phe Ile Val Tyr 165 170 175 Asn Val Thr Tyr Lys Glu Pro Arg Leu Ser Phe Pro Ile Asn Ile Leu 180 185 190 Met Ser Gly Val Tyr Tyr Thr Ala Arg Val Arg Val Arg Ser Gln Ile 195 200 205 Leu Thr Gly Thr Trp Ser Glu Trp Ser Pro Ser Ile Thr Trp Tyr Asn 210 215 220 His Phe Gln Leu Pro Leu Asn Pro Ala Phe Leu Tyr Lys Val Val Gly 225 230 235 240 Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Ala Ala His His His His 245 250 255 His His His His His His 260