< 110 > University of Southampton < 120 > COMBINED USE OF FC GAMMA RIIB ( CD 32 B ) AND CD 20 - SPECIFIC ANTIBODIES < 130 > IPP - 2013 - 0034 < 150 > GB 1013989 . 7 < 151 > 2010 - 08 - 20 < 160 > 106 < 170 > KopatentIn 2 . 0 < 210 > 1 < 211 > 330 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CH region < 400 > 1 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 < 210 > 2 < 211 > 105 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CL region < 400 > 2 Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 1 5 10 15 Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 20 25 30 Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 35 40 45 Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 50 55 60 Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 65 70 75 80 His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 85 90 95 Lys Thr Val Ala Pro Thr Glu Cys Ser 100 105 < 210 > 3 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 1 VH region < 400 > 3 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Trp Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 4 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 2 VH region < 400 > 4 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ala Tyr Asp Gly Ser Lys Lys Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Tyr Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 5 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 3 VH region < 400 > 5 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Trp Asn Gly Met Asp Val Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 6 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 4 VH region < 400 > 6 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asp Thr Ala Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp His Ser Val Ile Gly Ala Phe Asp Ile Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 7 < 211 > 118 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 5 VH region < 400 > 7 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gln Leu Gly Glu Ala Phe Asp Ile Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 < 210 > 8 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 6 VH region < 400 > 8 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gly Gly Asp Ile Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 9 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 7 VH region < 400 > 9 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Arg Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 10 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 8 VH region < 400 > 10 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Asp His Ser Ala Ala Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 11 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 9 VH region < 400 > 11 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asp Ser Ala Ile Ile Asp Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Glu Ala Ala Ala Gly Ala Phe Asp Ile Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 12 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 10 VH region < 400 > 12 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Leu Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 13 < 211 > 118 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 11 VH region < 400 > 13 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Phe Gly Tyr Ile Ile Leu Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 < 210 > 14 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 12 VH region < 400 > 14 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Thr Trp Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 15 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 13 VH region < 400 > 15 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Ser Val Gly Ala Tyr Ala Asn Asp Ala Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 16 < 211 > 113 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 1 VL region < 400 > 16 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Ser Gly Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 Gly < 210 > 17 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 2 VL region < 400 > 17 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Thr Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Val Ser Gly Trp Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 < 210 > 18 < 211 > 113 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 3 VL region < 400 > 18 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ala Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 Gly < 210 > 19 < 211 > 110 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 4 VL region < 400 > 19 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn 85 90 95 Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 < 210 > 20 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 5 VL region < 400 > 20 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 85 90 95 Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 < 210 > 21 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 6 VL region < 400 > 21 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Phe Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 < 210 > 22 < 211 > 110 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 7 VL region < 400 > 22 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Asp 85 90 95 Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 < 210 > 23 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 8 VL region < 400 > 23 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Gly Asn Ser Ile Arg Pro Ser Gly Gly Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 85 90 95 Ser Ser Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 < 210 > 24 < 211 > 113 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 9 VL region < 400 > 24 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Thr Asp Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Ser Gly Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 Gly < 210 > 25 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 10 VL region < 400 > 25 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ala Asp Asp His Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser 85 90 95 Gln Arg Ala Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 < 210 > 26 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 11 VL region < 400 > 26 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asp Tyr Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 < 210 > 27 < 211 > 109 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 12 VL region < 400 > 27 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Asn Ala Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 < 210 > 28 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 13 VL region < 400 > 28 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asp Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 < 210 > 29 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 1 CDRH 1 < 400 > 29 Asn Tyr Gly Met His 1 5 < 210 > 30 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 1 CDRH 2 < 400 > 30 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 31 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 1 CDRH 3 < 400 > 31 Glu Trp Arg Asp Ala Phe Asp Ile 1 5 < 210 > 32 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 1 CDRL 1 < 400 > 32 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 < 210 > 33 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 1 CDRL 2 < 400 > 33 Ser Asp Asn Gln Arg Pro Ser 1 5 < 210 > 34 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 1 CDRL 3 < 400 > 34 Ala Ala Trp Asp Asp Ser Leu Ser Gly Ser Trp Val 1 5 10 < 210 > 35 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 2 CDRH 1 < 400 > 35 Thr Tyr Gly Met His 1 5 < 210 > 36 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 2 CDRH 2 < 400 > 36 Val Ile Ala Tyr Asp Gly Ser Lys Lys Asp Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 37 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 2 CDRH 3 < 400 > 37 Glu Tyr Arg Asp Ala Phe Asp Ile 1 5 < 210 > 38 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 2 CDRL 1 < 400 > 38 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 < 210 > 39 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 2 CDRL 2 < 400 > 39 Gly Asn Ser Asn Arg Pro Ser 1 5 < 210 > 40 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 2 CDRL 3 < 400 > 40 Ala Ala Trp Asp Asp Ser Val Ser Gly Trp Met 1 5 10 < 210 > 41 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 3 CDRH 1 < 400 > 41 Asn Tyr Gly Met His 1 5 < 210 > 42 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 3 CDRH 2 < 400 > 42 Val Ile Ser Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 43 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 3 CDRH 3 < 400 > 43 Asp Arg Trp Asn Gly Met Asp Val 1 5 < 210 > 44 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 3 CDRL 1 < 400 > 44 Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 < 210 > 45 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 3 CDRL 2 < 400 > 45 Ala Asn Asn Gln Arg Pro Ser 1 5 < 210 > 46 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 3 CDRL 3 < 400 > 46 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Trp Val 1 5 10 < 210 > 47 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 4 CDRH 1 < 400 > 47 Ser Tyr Gly Met His 1 5 < 210 > 48 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 4 CDRH 2 < 400 > 48 Val Ile Ser Tyr Asp Gly Ser Asp Thr Ala Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 49 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 4 CDRH 3 < 400 > 49 Asp His Ser Val Ile Gly Ala Phe Asp Ile 1 5 10 < 210 > 50 < 211 > 13 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 4 CDRL 1 < 400 > 50 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 < 210 > 51 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 4 CDRL 2 < 400 > 51 Asp Asn Asn Lys Arg Pro Ser 1 5 < 210 > 52 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 4 CDRL 3 < 400 > 52 Ser Ser Tyr Ala Gly Ser Asn Asn Val Val 1 5 10 < 210 > 53 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 5 CDRH 1 < 400 > 53 Asn Tyr Gly Met His 1 5 < 210 > 54 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 5 CDRH 2 < 400 > 54 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 55 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 5 CDRH 3 < 400 > 55 Asp Gln Leu Gly Glu Ala Phe Asp Ile 1 5 < 210 > 56 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 5 CDRL 1 < 400 > 56 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 < 210 > 57 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 5 CDRL 2 < 400 > 57 Asp Asn Asn Lys Arg Pro Ser 1 5 < 210 > 58 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 5 CDRL 3 < 400 > 58 Ala Thr Trp Asp Asp Ser Leu Ser Gly Pro Val 1 5 10 < 210 > 59 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 6 CDRH 1 < 400 > 59 Asp Tyr Gly Met Ser 1 5 < 210 > 60 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 6 CDRH 2 < 400 > 60 Ala Ile Ser Gly Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 61 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 6 CDRH 3 < 400 > 61 Gly Asp Ile Asp Tyr Phe Asp Tyr 1 5 < 210 > 62 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 6 CDRL 1 < 400 > 62 Thr Gly Ser Ser Ser Asn Phe Gly Ala Gly Tyr Asp Val His 1 5 10 < 210 > 63 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 6 CDRL 2 < 400 > 63 Glu Asn Asn Lys Arg Pro Ser 1 5 < 210 > 64 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 6 CDRL 3 < 400 > 64 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 < 210 > 65 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 7 CDRH 1 < 400 > 65 Ser Tyr Gly Met His 1 5 < 210 > 66 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 7 CDRH 2 < 400 > 66 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 67 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 7 CDRH 3 < 400 > 67 Glu Arg Arg Asp Ala Phe Asp Ile 1 5 < 210 > 68 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 7 CDRL 1 < 400 > 68 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 < 210 > 69 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 7 CDRL 2 < 400 > 69 Ser Asp Asn Gln Arg Pro Ser 1 5 < 210 > 70 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 7 CDRL 3 < 400 > 70 Ala Thr Trp Asp Ser Asp Thr Pro Val 1 5 < 210 > 71 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 8 CDRH 1 < 400 > 71 Ser Tyr Gly Met His 1 5 < 210 > 72 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 8 CDRH 2 < 400 > 72 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 73 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 8 CDRH 3 < 400 > 73 Asp His Ser Ala Ala Gly Tyr Phe Asp Tyr 1 5 10 < 210 > 74 < 211 > 13 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 8 CDRL 1 < 400 > 74 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 < 210 > 75 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 8 CDRL 2 < 400 > 75 Gly Asn Ser Ile Arg Pro Ser 1 5 < 210 > 76 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 8 CDRL 3 < 400 > 76 Ala Ser Trp Asp Asp Ser Leu Ser Ser Pro Val 1 5 10 < 210 > 77 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 9 CDRH 1 < 400 > 77 Ser Tyr Gly Met His 1 5 < 210 > 78 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 9 CDRH 2 < 400 > 78 Gly Ile Ser Trp Asp Ser Ala Ile Ile Asp Tyr Ala Gly Ser Val Lys 1 5 10 15 Gly < 210 > 79 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 9 CDRH 3 < 400 > 79 Asp Glu Ala Ala Ala Gly Ala Phe Asp Ile 1 5 10 < 210 > 80 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 9 CDRL 1 < 400 > 80 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 < 210 > 81 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 9 CDRL 2 < 400 > 81 Gly Asn Thr Asp Arg Pro Ser 1 5 < 210 > 82 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 9 CDRL 3 < 400 > 82 Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val Val 1 5 10 < 210 > 83 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 10 CDRH 1 < 400 > 83 Ser Tyr Gly Met His 1 5 < 210 > 84 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 10 CDRH 2 < 400 > 84 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 85 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 10 CDRH 3 < 400 > 85 Glu Leu Tyr Asp Ala Phe Asp Ile 1 5 < 210 > 86 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 10 CDRL 1 < 400 > 86 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 < 210 > 87 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 10 CDRL 2 < 400 > 87 Ala Asp Asp His Arg Pro Ser 1 5 < 210 > 88 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 10 CDRL 3 < 400 > 88 Ala Ser Trp Asp Asp Ser Gln Arg Ala Val Ile 1 5 10 < 210 > 89 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 11 CDRH 1 < 400 > 89 Ser Tyr Gly Met His 1 5 < 210 > 90 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 11 CDRH 2 < 400 > 90 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 91 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 11 CDRH 3 < 400 > 91 Glu Phe Gly Tyr Ile Ile Leu Asp Tyr 1 5 < 210 > 92 < 211 > 13 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 11 CDRL 1 < 400 > 92 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 < 210 > 93 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 11 CDRL 2 < 400 > 93 Arg Asp Tyr Glu Arg Pro Ser 1 5 < 210 > 94 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 11 CDRL 3 < 400 > 94 Met Ala Trp Asp Asp Ser Leu Ser Gly Val Val 1 5 10 < 210 > 95 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 12 CDRH 1 < 400 > 95 Asn His Gly Met His 1 5 < 210 > 96 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 12 CDRH 2 < 400 > 96 Val Ile Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val Arg 1 5 10 15 Gly < 210 > 97 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 12 CDRH 3 < 400 > 97 Glu Thr Trp Asp Ala Phe Asp Val 1 5 < 210 > 98 < 211 > 13 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 12 CDRL 1 < 400 > 98 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Asn Ala Asn 1 5 10 < 210 > 99 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 12 CDRL 2 < 400 > 99 Asp Asn Asn Lys Arg Pro Ser 1 5 < 210 > 100 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 12 CDRL 3 < 400 > 100 Gln Ala Trp Asp Ser Ser Thr Val Val 1 5 < 210 > 101 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 13 CDRH 1 < 400 > 101 Ser Tyr Gly Ile Ser 1 5 < 210 > 102 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 13 CDRH 2 < 400 > 102 Gly Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 103 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 13 CDRH 3 < 400 > 103 Ser Val Gly Ala Tyr Ala Asn Asp Ala Phe Asp Ile 1 5 10 < 210 > 104 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 13 CDRL 1 < 400 > 104 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 < 210 > 105 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 13 CDRL 2 < 400 > 105 Gly Asp Thr Asn Arg Pro Ser 1 5 < 210 > 106 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Clone 13 CDRL 3 < 400 > 106 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10