SEQUENCE LISTING < 110 > OliPass Cosmeceuticals Han , Seon - Young Hwang , SeokJoon Kim , Ji Eun Sung , Kiho Lee , Yeonwoong < 120 > Melanophilin Antisense Oligonucleotides < 130 > 2020 dp 101 , 2020 op 101 pct < 150 > KR 10 - 2019 - 0087228 < 151 > 2019 - 07 - 18 < 160 > 14 < 170 > PatentIn version 3 . 2 < 210 > 1 < 211 > 14 < 212 > DNA < 213 > Artificial < 220 > < 223 > PNA modified oligonucleotide < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 14 ) < 223 > PNA modified oligonucleotide , human melanophilin targeted artificial sequence < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1 ) < 223 > Carbamated N - terminal < 220 > < 221 > modified _ base < 222 > ( 2 ) . .( 2 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 5 ) . .( 5 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 7 ) . .( 7 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 8 ) . .( 8 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 11 ) . .( 11 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 13 ) . .( 13 ) < 223 > n is a , g , c , or t < 400 > 1 gntcncnnct ngna 14 < 210 > 2 < 211 > 17 < 212 > DNA < 213 > Artificial < 220 > < 223 > PNA modified oligonucleotide < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 17 ) < 223 > PNA modified oligonucleotide , human melanophilin targeted artificial sequence < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1 ) < 223 > Carbamated N - terminal < 220 > < 221 > modified _ base < 222 > ( 1 ) . .( 1 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 3 ) . .( 3 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 5 ) . .( 5 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 8 ) . .( 8 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 10 ) . .( 10 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 11 ) . .( 11 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 14 ) . .( 14 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 16 ) . .( 16 ) < 223 > n is a , g , c , or t < 400 > 2 ngngntcncn nctngna 17 < 210 > 3 < 211 > 18 < 212 > DNA < 213 > Artificial < 220 > < 223 > PNA modified oligonucleotide < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 18 ) < 223 > PNA modified oligonucleotide , human melanophilin targeted artificial sequence < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1 ) < 223 > Carbamated N - terminal < 220 > < 221 > modified _ base < 222 > ( 2 ) . .( 2 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 4 ) . .( 4 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 7 ) . .( 7 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 9 ) . .( 9 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 10 ) . .( 10 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 13 ) . .( 13 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 15 ) . .( 15 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 18 ) . .( 18 ) < 223 > n is a , g , c , or t < 400 > 3 gngntcncnn ctngnatn 18 < 210 > 4 < 211 > 18 < 212 > DNA < 213 > Artificial < 220 > < 223 > PNA modified oligonucleotide < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 18 ) < 223 > PNA modified oligonucleotide , human melanophilin targeted artificial sequence < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1 ) < 223 > Carbamated N - terminal < 220 > < 221 > modified _ base < 222 > ( 2 ) . .( 2 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 5 ) . .( 5 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 7 ) . .( 7 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 8 ) . .( 8 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 11 ) . .( 11 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 13 ) . .( 13 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 16 ) . .( 16 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 18 ) . .( 18 ) < 223 > n is a , g , c , or t < 400 > 4 gntcncnnct ngnatntn 18 < 210 > 5 < 211 > 14 < 212 > DNA < 213 > Artificial < 220 > < 223 > PNA modified oligonucleotide < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 14 ) < 223 > PNA modified oligonucleotide , mouse melanophilin targeted artificial sequence < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1 ) < 223 > Carbamated N - terminal < 220 > < 221 > modified _ base < 222 > ( 2 ) . .( 2 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 5 ) . .( 5 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 7 ) . .( 7 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 8 ) . .( 8 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 11 ) . .( 11 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 13 ) . .( 13 ) < 223 > n is a , g , c , or t < 400 > 5 gnccncnnct ngna 14 < 210 > 6 < 211 > 17 < 212 > DNA < 213 > Artificial < 220 > < 223 > PNA modified oligonucleotide < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 17 ) < 223 > PNA modified oligonucleotide , mouse melanophilin targeted artificial sequence < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1 ) < 223 > Carbamated N - terminal < 220 > < 221 > modified _ base < 222 > ( 1 ) . .( 1 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 3 ) . .( 3 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 5 ) . .( 5 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 8 ) . .( 8 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 10 ) . .( 10 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 11 ) . .( 11 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 14 ) . .( 14 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 16 ) . .( 16 ) < 223 > n is a , g , c , or t < 400 > 6 ncngnccncn nctngna 17 < 210 > 7 < 211 > 18 < 212 > DNA < 213 > Artificial < 220 > < 223 > PNA modified oligonucleotide < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 18 ) < 223 > PNA modified oligonucleotide , mouse melanophilin targeted artificial sequence < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1 ) < 223 > Carbamated N - terminal < 220 > < 221 > modified _ base < 222 > ( 2 ) . .( 2 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 5 ) . .( 5 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 7 ) . .( 7 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 8 ) . .( 8 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 11 ) . .( 11 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 13 ) . .( 13 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 15 ) . .( 15 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 18 ) . .( 18 ) < 223 > n is a , g , c , or t < 400 > 7 gnccncnnct ngnangtn 18 < 210 > 8 < 211 > 18 < 212 > DNA < 213 > Artificial < 220 > < 223 > PNA modified oligonucleotide < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 18 ) < 223 > PNA modified oligonucleotide , mouse melanophilin targeted artificial sequence < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1 ) < 223 > Carbamated N - terminal < 220 > < 221 > modified _ base < 222 > ( 2 ) . .( 2 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 4 ) . .( 4 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 7 ) . .( 7 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 9 ) . .( 9 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 10 ) . .( 10 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 13 ) . .( 13 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 15 ) . .( 15 ) < 223 > n is a , g , c , or t < 220 > < 221 > modified _ base < 222 > ( 17 ) . .( 17 ) < 223 > n is a , g , c , or t < 400 > 8 cngnccncnn ctngnang 18 < 210 > 9 < 211 > 30 < 212 > RNA < 213 > Homo sapiens < 400 > 9 ccugugacau uccaggugug accccgacaa 30 < 210 > 10 < 211 > 30 < 212 > RNA < 213 > Mus musculus < 400 > 10 ccugugacuu ucuaggugug gccuggauga 30 < 210 > 11 < 211 > 20 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic primer < 400 > 11 tagctcagtg caccctgaca 20 < 210 > 12 < 211 > 20 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic primer < 400 > 12 gagagaccgg atcactttgg 20 < 210 > 13 < 211 > 19 < 212 > RNA < 213 > Artificial < 220 > < 223 > Mouse MLPH targeted siRNA < 400 > 13 gggcaaaaua caaaaggag 19 < 210 > 14 < 211 > 19 < 212 > RNA < 213 > Artificial < 220 > < 223 > Mouse MLPH targeted siRNA < 400 > 14 cuccuuuugu auuuugccc 19