SEQUENCE LISTING < 110 > KINDRED BIOSCIENCES , INC . < 120 > ANTI - IL 31 ANTIBODIES FOR VETERINARY USE < 130 > IPA 191049 - US < 150 > US 62 / 463 , 543 < 151 > 2017 - 02 - 24 < 150 > US PCT / US 2017 / 023788 < 151 > 2017 - 03 - 23 < 160 > 89 < 170 > PatentIn version 3 . 5 < 210 > 1 < 211 > 9 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 9 ) < 223 > Variable heavy chain CDR - H 1 amino acid sequence of mouse antibody clones M 14 , M 18 , and M 19 < 400 > 1 Gly Asp Ser Ile Thr Ser Gly Tyr Trp 1 5 < 210 > 2 < 211 > 16 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 16 ) < 223 > Variable heavy chain CDR - H 2 amino acid sequence of mouse antibody clones M 14 and M 19 < 400 > 2 Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 3 < 211 > 12 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 12 ) < 223 > Variable heavy chain CDR - H 3 amino acid sequence of mouse antibody clones M 14 , M 18 , and M 19 < 400 > 3 Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr 1 5 10 < 210 > 4 < 211 > 25 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 25 ) < 223 > Variable region heavy chain framework HC - FR 1 amino acid sequence of mouse antibody clone M 14 < 400 > 4 Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ser Val Thr 20 25 < 210 > 5 < 211 > 15 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 15 ) < 223 > Variable region heavy chain framework HC - FR 2 amino acid sequence of mouse antibody clone M 14 < 400 > 5 Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met Gly 1 5 10 15 < 210 > 6 < 211 > 30 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 30 ) < 223 > Variable region heavy chain framework HC - FR 3 amino acid sequence of mouse antibody clone M 14 < 400 > 6 Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu Gln 1 5 10 15 Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 20 25 30 < 210 > 7 < 211 > 11 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 11 ) < 223 > Variable region heavy chain framework HC - FR 4 amino acid sequence of mouse antibody clone M 14 < 400 > 7 Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 1 5 10 < 210 > 8 < 211 > 15 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 15 ) < 223 > Variable light chain CDR - L 1 amino acid sequence of mouse antibody clones M 14 and M 19 < 400 > 8 Arg Ala Ser Glu Ser Val Asp Thr Tyr Gly Asn Ser Phe Met His 1 5 10 15 < 210 > 9 < 211 > 7 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 7 ) < 223 > Variable light chain CDR - L 2 amino acid sequence of mouse antibody clones M 14 , M 18 , and M 19 < 400 > 9 Arg Ala Ser Asn Leu Glu Ser 1 5 < 210 > 10 < 211 > 9 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 9 ) < 223 > Variable light chain CDR - L 3 amino acid sequence of mouse antibody clones M 14 , M 18 , and M 19 < 400 > 10 Gln Gln Ser Tyr Glu Asp Pro Trp Thr 1 5 < 210 > 11 < 211 > 23 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 23 ) < 223 > Variable region light chain framework LC - FR 1 amino acid sequence of mouse antibody clone M 14 < 400 > 11 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys 20 < 210 > 12 < 211 > 15 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 15 ) < 223 > Variable region light chain framework LC - FR 2 amino acid sequence of mouse antibody clone M 14 < 400 > 12 Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Lys Leu Leu Ile Tyr 1 5 10 15 < 210 > 13 < 211 > 32 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 32 ) < 223 > Variable region light chain framework LC - FR 3 amino acid sequence of mouse antibody clone M 14 < 400 > 13 Gly Ile Pro Ala Arg Phe Gly Gly Ser Gly Ser Arg Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys 20 25 30 < 210 > 14 < 211 > 10 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 10 ) < 223 > Variable region light chain framework LC - FR 4 amino acid sequence of mouse antibody clone M 14 < 400 > 14 Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 1 5 10 < 210 > 15 < 211 > 118 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Caninized variable heavy chain amino acid sequence of mouse antibody clone M 14 < 400 > 15 Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 20 25 30 Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 35 40 45 Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 65 70 75 80 Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 < 210 > 16 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Caninized variable light chain amino acid sequence of mouse antibody clone M 14 < 400 > 16 Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 20 25 30 Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 35 40 45 Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 50 55 60 Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 65 70 75 80 Pro Val Gln Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 17 < 211 > 448 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Caninized heavy chain sequence from mouse antibody clone M 14 and canine IgG - A < 400 > 17 Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 20 25 30 Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 35 40 45 Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 65 70 75 80 Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 130 135 140 Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 165 170 175 Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 180 185 190 Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His Pro Ala Ser 195 200 205 Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg Cys Thr Asp 210 215 220 Thr Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln 260 265 270 Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln 275 280 285 Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 290 295 300 Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg 305 310 315 320 Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 325 330 335 Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser 340 345 350 Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile 355 360 365 Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 370 375 380 Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp 385 390 395 400 Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr 420 425 430 Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 435 440 445 < 210 > 18 < 211 > 453 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Caninized heavy chain sequence from mouse antibody clone M 14 and canine IgG - B < 400 > 18 Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 20 25 30 Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 35 40 45 Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 65 70 75 80 Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 130 135 140 Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 180 185 190 Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 195 200 205 Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 210 215 220 Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 225 230 235 240 Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 245 250 255 Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro 260 265 270 Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 275 280 285 Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 290 295 300 Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 305 310 315 320 Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 325 330 335 Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 340 345 350 Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 355 360 365 Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 370 375 380 Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 385 390 395 400 Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 405 410 415 Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 420 425 430 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 435 440 445 His Ser Pro Gly Lys 450 < 210 > 19 < 211 > 451 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Caninized heavy chain sequence from mouse antibody clone M 14 and canine IgG - C < 400 > 19 Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 20 25 30 Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 35 40 45 Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 65 70 75 80 Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Cys Gly Ser Gln Ser Gly Ser Thr Val Ala Leu Ala 130 135 140 Cys Leu Val Ser Gly Tyr Ile Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Val Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 180 185 190 Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Thr 195 200 205 Asn Thr Lys Val Asp Lys Pro Val Ala Lys Glu Cys Glu Cys Lys Cys 210 215 220 Asn Cys Asn Asn Cys Pro Cys Pro Gly Cys Gly Leu Leu Gly Gly Pro 225 230 235 240 Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Val Thr Ala 245 250 255 Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asn 260 265 270 Pro Glu Val Gln Ile Ser Trp Phe Val Asp Ser Lys Gln Val Gln Thr 275 280 285 Ala Asn Thr Gln Pro Arg Glu Glu Gln Ser Asn Gly Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Ser Gly Lys Gln 305 310 315 320 Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Glu 325 330 335 Ile Ile Ser Lys Thr Pro Gly Gln Ala His Gln Pro Asn Val Tyr Val 340 345 350 Leu Pro Pro Ser Arg Asp Glu Met Ser Lys Asn Thr Val Thr Leu Thr 355 360 365 Cys Leu Val Lys Asp Phe Phe Pro Pro Glu Ile Asp Val Glu Trp Gln 370 375 380 Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Met Thr Pro Pro 385 390 395 400 Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 405 410 415 Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 420 425 430 His Glu Ala Leu His Asn His Tyr Thr Gln Ile Ser Leu Ser His Ser 435 440 445 Pro Gly Lys 450 < 210 > 20 < 211 > 449 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Caninized heavy chain sequence from mouse antibody clone M 14 and canine IgG - D < 400 > 20 Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 20 25 30 Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 35 40 45 Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 65 70 75 80 Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 130 135 140 Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Thr Val Thr Val Pro Ser Ser 180 185 190 Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His Pro Ala Ser 195 200 205 Asn Thr Lys Val Asp Lys Pro Val Pro Lys Glu Ser Thr Cys Lys Cys 210 215 220 Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe 225 230 235 240 Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro 245 250 255 Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val 260 265 270 Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr 275 280 285 Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys 305 310 315 320 Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 325 330 335 Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 340 345 350 Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu 355 360 365 Ile Lys Asp Phe Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn 370 375 380 Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu 385 390 395 400 Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu 420 425 430 Ala Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly 435 440 445 Lys < 210 > 21 < 211 > 221 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Caninized light chain sequence from mouse antibody clone M 14 and canine light chain constant region < 400 > 21 Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 20 25 30 Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 35 40 45 Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 50 55 60 Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 65 70 75 80 Pro Val Gln Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 115 120 125 Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 130 135 140 Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 145 150 155 160 Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 180 185 190 Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 195 200 205 Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 210 215 220 < 210 > 22 < 211 > 159 < 212 > PRT < 213 > Canidae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 159 ) < 223 > Canine IL 31 amino acid sequence < 400 > 22 Met Leu Ser His Thr Gly Pro Ser Arg Phe Ala Leu Phe Leu Leu Cys 1 5 10 15 Ser Met Glu Thr Leu Leu Ser Ser His Met Ala Pro Thr His Gln Leu 20 25 30 Pro Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 35 40 45 Arg Gly Leu Leu Glu Asp Tyr Gln Lys Lys Glu Thr Gly Val Pro Glu 50 55 60 Ser Asn Arg Thr Leu Leu Leu Cys Leu Thr Ser Asp Ser Gln Pro Pro 65 70 75 80 Arg Leu Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 85 90 95 Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 100 105 110 Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp 115 120 125 Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 130 135 140 Ala Cys Leu Glu Ser Val Phe Lys Ser Leu Asn Ser Gly Pro Gln 145 150 155 < 210 > 23 < 211 > 17 < 212 > PRT < 213 > Canidae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 17 ) < 223 > Canine IL 31 epitope < 400 > 23 Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser Arg 1 5 10 15 Gly < 210 > 24 < 211 > 111 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 111 ) < 223 > Variable light chain amino acid sequence of mouse antibody clone M 14 < 400 > 24 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 20 25 30 Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro 35 40 45 Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 50 55 60 Arg Phe Gly Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 65 70 75 80 Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 25 < 211 > 118 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 118 ) < 223 > Variable heavy chain amino acid sequence of mouse antibody clone M 14 < 400 > 25 Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 20 25 30 Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 35 40 45 Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 65 70 75 80 Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Ser Val Thr Val Ser Ser 115 < 210 > 26 < 211 > 221 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Chimeric variable light chain of mouse antibody clone M 14 and canine light chain constant region < 400 > 26 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 20 25 30 Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro 35 40 45 Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 50 55 60 Arg Phe Gly Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 65 70 75 80 Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 115 120 125 Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 130 135 140 Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 145 150 155 160 Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 180 185 190 Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 195 200 205 Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 210 215 220 < 210 > 27 < 211 > 453 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Chimeric variable heavy chain of mouse antibody clone M 14 and canine IgG - B < 400 > 27 Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 20 25 30 Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 35 40 45 Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 65 70 75 80 Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 130 135 140 Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 180 185 190 Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 195 200 205 Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 210 215 220 Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 225 230 235 240 Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 245 250 255 Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro 260 265 270 Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 275 280 285 Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 290 295 300 Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 305 310 315 320 Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 325 330 335 Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 340 345 350 Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 355 360 365 Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 370 375 380 Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 385 390 395 400 Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 405 410 415 Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 420 425 430 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 435 440 445 His Ser Pro Gly Lys 450 < 210 > 28 < 211 > 159 < 212 > PRT < 213 > Felis catus < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 159 ) < 223 > Feline IL 31 amino acid sequence NCBI ref : XP _ 011286140 . 1 [ felis catus ] < 400 > 28 Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 1 5 10 15 Cys Met Glu Thr Leu Leu Pro Ser His Met Ala Pro Ala His Arg Leu 20 25 30 Gln Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Arg Pro Met Ser 35 40 45 Lys Gly Leu Leu Gln Asp Tyr Leu Lys Lys Glu Ile Gly Leu Pro Glu 50 55 60 Ser Asn His Ser Ser Leu Pro Cys Leu Ser Ser Asp Ser Gln Leu Pro 65 70 75 80 His Ile Asn Gly Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 85 90 95 Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 100 105 110 Leu Lys Phe Gln Arg Glu Pro Glu Ala Lys Val Ser Met Pro Ala Asp 115 120 125 Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala Val Leu Gln Gln Phe Ser 130 135 140 Ala Cys Leu Glu His Val Leu Gln Ser Leu Asn Ser Gly Pro Gln 145 150 155 < 210 > 29 < 211 > 209 < 212 > PRT < 213 > Equus caballus < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 209 ) < 223 > Equine IL 31 amino acid sequence < 400 > 29 Met Val Ser His Ile Gly Ser Thr Arg Phe Ala Leu Phe Leu Leu Cys 1 5 10 15 Cys Leu Gly Thr Leu Met Phe Ser His Thr Gly Pro Ile Tyr Gln Leu 20 25 30 Gln Pro Lys Glu Ile Gln Ala Ile Ile Val Glu Leu Gln Asn Leu Ser 35 40 45 Lys Lys Leu Leu Asp Asp Tyr Leu Asn Lys Glu Lys Gly Val Gln Lys 50 55 60 Phe Asp Ser Asp Leu Pro Ser Cys Phe Thr Ser Asp Ser Gln Ala Pro 65 70 75 80 Gly Asn Ile Asn Ser Ser Ala Ile Leu Pro Tyr Phe Lys Ala Ile Ser 85 90 95 Pro Ser Leu Asn Asn Asp Lys Ser Leu Tyr Ile Ile Glu Gln Leu Asp 100 105 110 Lys Leu Asn Phe Gln Asn Ala Pro Glu Thr Glu Val Ser Met Pro Thr 115 120 125 Asp Asn Phe Glu Arg Lys Arg Phe Ile Leu Thr Ile Leu Arg Trp Phe 130 135 140 Ser Asn Cys Leu Glu Leu Ala Met Lys Thr Leu Thr Thr Ala Glu Gln 145 150 155 160 Ala Leu Pro Pro Leu Asp Pro Ser Thr Pro His Ala Gly Ala Val Ala 165 170 175 Leu Thr His His Gln Gln Asp Arg Thr Ala Leu Asp Arg Ala Val Phe 180 185 190 Pro Phe Val Trp Ala Ala Pro Arg Gly Gly Glu Val Gly Asp Gly Gly 195 200 205 His < 210 > 30 < 211 > 221 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Chimeric variable light chain of mouse antibody clone M 14 and feline light chain constant region < 400 > 30 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 20 25 30 Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro 35 40 45 Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 50 55 60 Arg Phe Gly Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 65 70 75 80 Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Ser Asp Ala Gln Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu 115 120 125 Leu His Thr Gly Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr 130 135 140 Pro Lys Glu Val Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Asn 145 150 155 160 Lys Gly Ile Gln Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln Ser 180 185 190 His Glu Lys Phe Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr 195 200 205 Leu Val Lys Ser Phe Asn Arg Ser Glu Cys Gln Arg Glu 210 215 220 < 210 > 31 < 211 > 453 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Chimeric variable heavy chain of mouse antibody clone M 14 and feline heavy chain constant region < 400 > 31 Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 20 25 30 Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 35 40 45 Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 65 70 75 80 Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr Val Ala Leu Ala 130 135 140 Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 180 185 190 Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala His Pro Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp His Pro Pro Gly 210 215 220 Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro Glu Met Leu Gly 225 230 235 240 Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser 245 250 255 Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro 260 265 270 Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp Asn Thr Gln Val 275 280 285 Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 290 295 300 Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly 305 310 315 320 Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Pro Ile 325 330 335 Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val 340 345 350 Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg Asn Lys Val Ser 355 360 365 Val Thr Cys Leu Ile Lys Ser Phe His Pro Pro Asp Ile Ala Val Glu 370 375 380 Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr 385 390 395 400 Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu 405 410 415 Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser 420 425 430 Val Ser His Glu Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr 435 440 445 Gln Ser Pro Gly Lys 450 < 210 > 32 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Felinized variable light chain sequence from mouse antibody clone M 14 < 400 > 32 Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 20 25 30 Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 35 40 45 Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Glu Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 33 < 211 > 118 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Felinized variable heavy chain sequence from mouse antibody clone M 14 < 400 > 33 Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 20 25 30 Tyr Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 35 40 45 Ala Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Leu Asn Asn Leu Lys Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 < 210 > 34 < 211 > 221 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Felinized light chain sequence from mouse antibody clone M 14 < 400 > 34 Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 20 25 30 Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 35 40 45 Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Glu Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Ser Asp Ala Gln Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu 115 120 125 Leu His Thr Gly Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr 130 135 140 Pro Lys Glu Val Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Asn 145 150 155 160 Lys Gly Ile Gln Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln Ser 180 185 190 His Glu Lys Phe Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr 195 200 205 Leu Val Lys Ser Phe Asn Arg Ser Glu Cys Gln Arg Glu 210 215 220 < 210 > 35 < 211 > 453 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Felinized heavy chain sequence from mouse antibody clone M 14 < 400 > 35 Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 20 25 30 Tyr Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 35 40 45 Ala Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Leu Asn Asn Leu Lys Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr Val Ala Leu Ala 130 135 140 Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 180 185 190 Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala His Pro Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp His Pro Pro Gly 210 215 220 Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro Glu Met Leu Gly 225 230 235 240 Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser 245 250 255 Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro 260 265 270 Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp Asn Thr Gln Val 275 280 285 Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 290 295 300 Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly 305 310 315 320 Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Pro Ile 325 330 335 Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val 340 345 350 Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg Asn Lys Val Ser 355 360 365 Val Thr Cys Leu Ile Lys Ser Phe His Pro Pro Asp Ile Ala Val Glu 370 375 380 Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr 385 390 395 400 Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu 405 410 415 Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser 420 425 430 Val Ser His Glu Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr 435 440 445 Gln Ser Pro Gly Lys 450 < 210 > 36 < 211 > 238 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 238 ) < 223 > Light chain amino acid sequence of mouse antibody clone M 14 < 400 > 36 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 20 25 30 Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 35 40 45 Val Asp Thr Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser 50 55 60 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 65 70 75 80 Gly Ile Pro Ala Arg Phe Gly Gly Ser Gly Ser Arg Thr Asp Phe Thr 85 90 95 Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys 100 105 110 Gln Gln Ser Tyr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 130 135 140 Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 145 150 155 160 Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 165 170 175 Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 180 185 190 Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 195 200 205 Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 210 215 220 Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 225 230 235 < 210 > 37 < 211 > 238 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 238 ) < 223 > Light chain amino acid sequence of mouse antibody clone M 18 < 400 > 37 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 20 25 30 Val Ser Pro Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 35 40 45 Val Asp Thr Tyr Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro 50 55 60 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 65 70 75 80 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 85 90 95 Leu Thr Ile Asn Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys 100 105 110 Gln Gln Ser Tyr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 130 135 140 Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 145 150 155 160 Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 165 170 175 Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 180 185 190 Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 195 200 205 Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 210 215 220 Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 225 230 235 < 210 > 38 < 211 > 238 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 238 ) < 223 > Light chain amino acid sequence of mouse antibody clone M 19 < 400 > 38 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 20 25 30 Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 35 40 45 Val Asp Thr Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro 50 55 60 Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 65 70 75 80 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 85 90 95 Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Ile Ala Thr Tyr Tyr Cys 100 105 110 Gln Gln Ser Tyr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 130 135 140 Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 145 150 155 160 Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 165 170 175 Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 180 185 190 Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 195 200 205 Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 210 215 220 Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 225 230 235 < 210 > 39 < 211 > 238 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 238 ) < 223 > Light chain amino acid sequence of mouse antibody clone M 87 < 400 > 39 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 20 25 30 Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser 35 40 45 Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro 50 55 60 Gly Gln Pro Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser 65 70 75 80 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 100 105 110 Gln His Ile Arg Glu Leu Thr Arg Ser Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 130 135 140 Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 145 150 155 160 Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 165 170 175 Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 180 185 190 Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 195 200 205 Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 210 215 220 Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 225 230 235 < 210 > 40 < 211 > 152 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 152 ) < 223 > Variable and hinge heavy chain amino acid sequence of mouse antibody clone M 14 < 400 > 40 Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 1 5 10 15 Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys 20 25 30 Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile 35 40 45 Thr Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu 50 55 60 Glu Tyr Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro 65 70 75 80 Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 85 90 95 Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 100 105 110 Tyr Cys Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 130 135 140 Val Tyr Pro Leu Ala Pro Gly Ser 145 150 < 210 > 41 < 211 > 152 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 152 ) < 223 > Variable and hinge heavy chain amino acid sequence of mouse antibody clone M 18 < 400 > 41 Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 1 5 10 15 Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys 20 25 30 Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile 35 40 45 Thr Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu 50 55 60 Glu Tyr Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro 65 70 75 80 Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 85 90 95 Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 100 105 110 Tyr Cys Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 130 135 140 Val Tyr Pro Leu Ala Pro Gly Ser 145 150 < 210 > 42 < 211 > 152 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 152 ) < 223 > Variable and hinge heavy chain amino acid sequence of mouse antibody clone M 19 < 400 > 42 Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 1 5 10 15 Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys 20 25 30 Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile 35 40 45 Thr Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Glu Leu 50 55 60 Glu Tyr Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro 65 70 75 80 Ser Leu Lys Ser Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 85 90 95 Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 100 105 110 Tyr Cys Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 130 135 140 Val Tyr Pro Leu Ala Pro Gly Ser 145 150 < 210 > 43 < 211 > 154 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 154 ) < 223 > Variable and hinge heavy chain amino acid sequence of mouse antibody clone M 87 < 400 > 43 Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 1 5 10 15 Val Leu Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 20 25 30 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 35 40 45 Thr Asp Tyr Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 50 55 60 Glu Trp Leu Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu 65 70 75 80 Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 85 90 95 Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser 100 105 110 Ala Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Gly Ser Cys Phe Asp Tyr 115 120 125 Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro 130 135 140 Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser 145 150 < 210 > 44 < 211 > 137 < 212 > PRT < 213 > Canidae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 137 ) < 223 > Mature canine IL 31 amino acid sequence < 400 > 44 Ser Ser His Met Ala Pro Thr His Gln Leu Pro Pro Ser Asp Val Arg 1 5 10 15 Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp 20 25 30 Tyr Gln Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu 35 40 45 Leu Cys Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala 50 55 60 Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile 65 70 75 80 Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu 85 90 95 Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser 100 105 110 Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val 115 120 125 Phe Lys Ser Leu Asn Ser Gly Pro Gln 130 135 < 210 > 45 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > IL 31 epitope < 220 > < 221 > MISC _ FEATURE < 222 > ( 4 ) . .( 4 ) < 223 > X is any amino acid ; or wherein X is a hydrophobic amino acid , or wherein X is selected from A , V , I , and L , or wherein X is selected from V and I < 220 > < 221 > MISC _ FEATURE < 222 > ( 5 ) . .( 5 ) < 223 > X is any amino acid ; or wherein X is a hydrophilic amino acid , or wherein X is selected from A , R , K , Q , and N ; or wherein X is selected from R and Q < 400 > 45 Pro Ser Asp Xaa Xaa Lys Ile 1 5 < 210 > 46 < 211 > 164 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 164 ) < 223 > Human IL 31 precursor amino acid sequence NCBI ref : NP _ 001014358 . 1 < 400 > 46 Met Ala Ser His Ser Gly Pro Ser Thr Ser Val Leu Phe Leu Phe Cys 1 5 10 15 Cys Leu Gly Gly Trp Leu Ala Ser His Thr Leu Pro Val Arg Leu Leu 20 25 30 Arg Pro Ser Asp Asp Val Gln Lys Ile Val Glu Glu Leu Gln Ser Leu 35 40 45 Ser Lys Met Leu Leu Lys Asp Val Glu Glu Glu Lys Gly Val Leu Val 50 55 60 Ser Gln Asn Tyr Thr Leu Pro Cys Leu Ser Pro Asp Ala Gln Pro Pro 65 70 75 80 Asn Asn Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg 85 90 95 Gln Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp 100 105 110 Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr 115 120 125 Asp Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe 130 135 140 Ser Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln 145 150 155 160 Gln Ala Thr Thr < 210 > 47 < 211 > 177 < 212 > PRT < 213 > Odobenus rosmarus divergens < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 177 ) < 223 > Predicted walrus IL 31 amino acid sequence NCBI ref : XP _ 004395998 . 1 [ odobeus rosmarus divergens ] < 400 > 47 Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 1 5 10 15 Phe Met Gly Thr Ser Leu Thr Ser Gln Thr Ala Pro Ile His Gln Leu 20 25 30 His Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 35 40 45 Lys Gly Leu Leu Glu Asp Tyr Leu Lys Lys Glu Met Gly Val Pro Glu 50 55 60 Ser Asn His Phe Leu Leu Pro Cys Leu Thr Ser Asp Ser Gln Pro Pro 65 70 75 80 Arg Ile Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 85 90 95 Leu Ser Asp Lys Asn Thr Ile Asn Lys Ile Ile Glu Gln Leu Asp Lys 100 105 110 Leu Lys Phe Gln His Glu Pro Glu Thr Glu Val Ser Val Pro Ala Asp 115 120 125 Thr Phe Glu Ser Lys Ser Phe Ile Leu Ala Ile Leu Gln Gln Phe Ser 130 135 140 Ala Cys Leu Asp His Val Phe Lys Ser Leu Asn Pro Gly Pro Gln Gln 145 150 155 160 Val Met Gln Gly His Leu Ile Glu Pro Ile Pro Ser Gly Thr Ala Asp 165 170 175 Val < 210 > 48 < 211 > 187 < 212 > PRT < 213 > Odobenus rosmarus divergens < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 187 ) < 223 > Walrus _ IL 31 _ His 6 < 400 > 48 Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 1 5 10 15 Phe Met Gly Thr Ser Leu Thr Ser Gln Thr Ala Pro Ile His Gln Leu 20 25 30 His Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 35 40 45 Lys Gly Leu Leu Glu Asp Tyr Leu Lys Lys Glu Met Gly Val Pro Glu 50 55 60 Ser Asn His Phe Leu Leu Pro Cys Leu Thr Ser Asp Ser Gln Pro Pro 65 70 75 80 Arg Ile Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 85 90 95 Leu Ser Asp Lys Asn Thr Ile Asn Lys Ile Ile Glu Gln Leu Asp Lys 100 105 110 Leu Lys Phe Gln His Glu Pro Glu Thr Glu Val Ser Val Pro Ala Asp 115 120 125 Thr Phe Glu Ser Lys Ser Phe Ile Leu Ala Ile Leu Gln Gln Phe Ser 130 135 140 Ala Cys Leu Asp His Val Phe Lys Ser Leu Asn Pro Gly Pro Gln Gln 145 150 155 160 Val Met Gln Gly His Leu Ile Glu Pro Ile Pro Ser Gly Thr Ala Asp 165 170 175 Val Gly Ser Gly Ser His His His His His His 180 185 < 210 > 49 < 211 > 163 < 212 > PRT < 213 > Papio anubis < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 163 ) < 223 > Predicted olive baboon IL 31 amino acid sequence NCBI ref : XP _ 003907358 . 1 [ papio anubis ] < 400 > 49 Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 1 5 10 15 Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 20 25 30 Gln Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 35 40 45 Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 50 55 60 Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 65 70 75 80 Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Glu 85 90 95 Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 100 105 110 Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 115 120 125 Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 130 135 140 Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 145 150 155 160 Ala Thr Thr < 210 > 50 < 211 > 173 < 212 > PRT < 213 > Papio anubis < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 173 ) < 223 > Olive baboon _ IL 31 _ His 6 < 400 > 50 Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 1 5 10 15 Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 20 25 30 Gln Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 35 40 45 Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 50 55 60 Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 65 70 75 80 Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Glu 85 90 95 Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 100 105 110 Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 115 120 125 Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 130 135 140 Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 145 150 155 160 Ala Thr Thr Gly Ser Gly Ser His His His His His His 165 170 < 210 > 51 < 211 > 159 < 212 > PRT < 213 > Ursus maritimus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 159 ) < 223 > Predicted polar bear IL 31 amino acid sequence NCBI ref : XP _ 008687166 . 1 [ ursus maritimus ] < 400 > 51 Met Leu Ser Arg Ala Val Pro Ala Gly Phe Ala Leu Phe Leu Leu Cys 1 5 10 15 Tyr Met Glu Thr Leu Leu Thr Ser His Thr Ala Pro Thr His Arg Leu 20 25 30 Pro Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 35 40 45 Lys Gly Leu Leu Glu Asp Tyr Leu Lys Lys Glu Thr Gly Leu Pro Glu 50 55 60 Ser Asn His Ser Leu Val Pro Cys Leu Thr Ser Asp Ser Glu Ala Pro 65 70 75 80 His Ile Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 85 90 95 Leu Ser Asp Lys Asn Val Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 100 105 110 Leu Lys Phe Gln His Glu Pro Glu Thr Glu Val Ser Val Pro Ala Asp 115 120 125 Thr Phe Glu Gly Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 130 135 140 Ala Cys Leu Glu Arg Val Phe Lys Ser Leu Asn Pro Gly Ala Gln 145 150 155 < 210 > 52 < 211 > 185 < 212 > PRT < 213 > Ursus maritimus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 185 ) < 223 > Predicted weddell seal IL 31 amino acid sequence NCBI ref : XP _ 006746595 . 1 [ leptonychotes weddellii ] < 400 > 52 Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 1 5 10 15 Phe Met Glu Thr Ser Leu Thr Ser Gln Thr Val Pro Ile His Gln Leu 20 25 30 Gln Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 35 40 45 Lys Gly Leu Leu Glu Asp Tyr Leu Lys Lys Glu Met Gly Val Pro Glu 50 55 60 Ser Asn His Phe Leu Leu Pro Cys Leu Thr Ser Asp Ser Gln Pro Pro 65 70 75 80 Arg Ile Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 85 90 95 Leu Ser Asp Lys Asn Ile Ile Asn Lys Ile Ile Glu Gln Leu Asp Lys 100 105 110 Leu Lys Phe Gln His Glu Pro Glu Thr Glu Val Ser Val Pro Ala Asp 115 120 125 Thr Phe Glu Ser Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 130 135 140 Ala Cys Leu Gly His Val Leu Lys Ser Leu Asn Pro Gly Pro Gln Gln 145 150 155 160 Val Met Gln Gly His Leu Ala Lys Pro Ile Pro Ser Gly Thr Ala Asp 165 170 175 Met Tyr Glu Thr Leu Arg His His His 180 185 < 210 > 53 < 211 > 159 < 212 > PRT < 213 > Panthera tigris altaica < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 159 ) < 223 > Predicted amur tiger IL 31 amino acid sequence NCBI ref : XP _ 007079636 . 1 [ panther tigris altaica ] < 400 > 53 Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 1 5 10 15 Cys Met Glu Thr Leu Leu Pro Ser His Met Ala Pro Thr His Arg Leu 20 25 30 Gln Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Arg Pro Met Ser 35 40 45 Lys Gly Leu Leu Gln Asp Tyr Leu Lys Lys Glu Met Gly Leu Pro Glu 50 55 60 Ser Asn His Ser Ser Leu Pro Cys Leu Ser Ser Asp Ser Gln Leu Pro 65 70 75 80 His Ile Asn Gly Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 85 90 95 Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 100 105 110 Leu Lys Phe Gln Arg Glu Pro Glu Ala Glu Val Ser Met Pro Ala Asp 115 120 125 Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala Val Leu Gln Gln Phe Ser 130 135 140 Ala Cys Leu Glu His Val Leu Gln Ser Leu Asn Ser Gly Pro Gln 145 150 155 < 210 > 54 < 211 > 159 < 212 > PRT < 213 > Acinonyx jubatus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 159 ) < 223 > Predicted cheetah IL 31 amino acid sequence NCBI ref : XP _ 014919275 . 1 [ acinonyx jubatus ] < 400 > 54 Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 1 5 10 15 Cys Met Glu Thr Leu Leu Pro Ser His Met Ala Pro Thr His Arg Leu 20 25 30 Gln Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Arg Pro Met Ser 35 40 45 Lys Gly Leu Leu Gln Asp Tyr Leu Lys Lys Glu Met Gly Leu Pro Glu 50 55 60 Ser Asn His Ser Ser Leu Pro Cys Leu Ser Ser Asp Ser Gln Leu Pro 65 70 75 80 His Ile Asn Gly Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 85 90 95 Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 100 105 110 Leu Lys Phe Gln Arg Glu Pro Glu Ala Glu Val Ser Met Pro Ala Asp 115 120 125 Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala Val Leu Gln Gln Phe Ser 130 135 140 Ala Cys Leu Glu His Val Leu Gln Ser Leu Asn Ser Gly Ser Gln 145 150 155 < 210 > 55 < 211 > 163 < 212 > PRT < 213 > Macaca fascicularis < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 163 ) < 223 > Predicted crab - eating macaque IL 31 amino acid sequence GenBank ref : EHH 66805 . 1 [ macaca fascicularis ] < 400 > 55 Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 1 5 10 15 Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 20 25 30 Gln Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 35 40 45 Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 50 55 60 Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 65 70 75 80 Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln 85 90 95 Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 100 105 110 Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 115 120 125 Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 130 135 140 Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 145 150 155 160 Ala Thr Thr < 210 > 56 < 211 > 158 < 212 > PRT < 213 > Macaca mulatta < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 158 ) < 223 > Predicted rhesus monkey IL 31 amino acid sequence ( partial ) GenBank ref : EHH 21279 . 1 [ macaca mulatta ] < 400 > 56 Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys Cys Leu Gly Gly Trp 1 5 10 15 Leu Thr Ser His Thr Leu Pro Val His Phe Leu Gln Pro Ser Asp Ile 20 25 30 Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser Lys Met Leu Leu Lys 35 40 45 Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser Gln Asn Tyr Thr Leu 50 55 60 Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn Ile Ile His Ser Pro 65 70 75 80 Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln Leu Asp Asn Lys Ser 85 90 95 Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys Leu Ile Phe Gln Asp 100 105 110 Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp Thr His Glu Cys Lys 115 120 125 Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser Glu Cys Met Asp Leu 130 135 140 Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln Ala Thr Thr 145 150 155 < 210 > 57 < 211 > 163 < 212 > PRT < 213 > Mandrillus leucophaeus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 163 ) < 223 > Predicted drill IL 31 amino acid sequence NCBI ref : XP _ 011819882 . 1 [ mandrillus leucophaeus ] < 400 > 57 Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 1 5 10 15 Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 20 25 30 Gln Pro Ser Asp Ile Gln Lys Ile Val Lys Glu Leu Gln Ser Leu Ser 35 40 45 Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 50 55 60 Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 65 70 75 80 Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln 85 90 95 Leu Asp Asn Arg Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 100 105 110 Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 115 120 125 Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 130 135 140 Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 145 150 155 160 Ala Thr Thr < 210 > 58 < 211 > 163 < 212 > PRT < 213 > Chlorocebus sabaeus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 163 ) < 223 > Predicted green monkey IL 31 amino acid sequence NCBI ref : XP _ 008003211 . 1 [ chlorocebus sabaeus ] < 400 > 58 Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 1 5 10 15 Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 20 25 30 Gln Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 35 40 45 Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 50 55 60 Gln Asn Tyr Lys Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 65 70 75 80 Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln 85 90 95 Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 100 105 110 Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 115 120 125 Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 130 135 140 Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 145 150 155 160 Ala Thr Thr < 210 > 59 < 211 > 163 < 212 > PRT < 213 > Cercocebus atys < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 163 ) < 223 > Predicted sooty mangebey IL 31 amino acid sequence NCBI ref : XP _ 011926625 . 1 [ cercocebus atys ] < 400 > 59 Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 1 5 10 15 Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 20 25 30 Gln Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 35 40 45 Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 50 55 60 Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 65 70 75 80 Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln 85 90 95 Leu Asp Asn Arg Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 100 105 110 Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 115 120 125 Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 130 135 140 Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 145 150 155 160 Ala Thr Thr < 210 > 60 < 211 > 163 < 212 > PRT < 213 > Rhinopithecus roxellana < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 163 ) < 223 > Predicted golden snub - nosed monkey IL 31 amino acid sequence NCBI ref : XP _ 010366647 . 1 [ rhinopithecus roxellana ] < 400 > 60 Met Ala Ser His Ser Gly Pro Thr Thr Ser Val Leu Phe Leu Leu Cys 1 5 10 15 Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 20 25 30 Arg Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 35 40 45 Lys Met Leu Leu Lys Asp Val Glu Glu Asp Lys Gly Val Leu Val Ser 50 55 60 Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 65 70 75 80 Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln 85 90 95 Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 100 105 110 Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 115 120 125 Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 130 135 140 Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 145 150 155 160 Ala Thr Thr < 210 > 61 < 211 > 163 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 163 ) < 223 > Murine IL 31 precursor amino acid sequence NCBI ref : NP _ 083870 [ mus musculus ] < 400 > 61 Met Ile Phe His Thr Gly Thr Thr Lys Pro Thr Leu Val Leu Leu Cys 1 5 10 15 Cys Ile Gly Thr Trp Leu Ala Thr Cys Ser Leu Ser Phe Gly Ala Pro 20 25 30 Ile Ser Lys Glu Asp Leu Arg Thr Thr Ile Asp Leu Leu Lys Gln Glu 35 40 45 Ser Gln Asp Leu Tyr Asn Asn Tyr Ser Ile Lys Gln Ala Ser Gly Met 50 55 60 Ser Ala Asp Glu Ser Ile Gln Leu Pro Cys Phe Ser Leu Asp Arg Glu 65 70 75 80 Ala Leu Thr Asn Ile Ser Val Ile Ile Ala His Leu Glu Lys Val Lys 85 90 95 Val Leu Ser Glu Asn Thr Val Asp Thr Ser Trp Val Ile Arg Trp Leu 100 105 110 Thr Asn Ile Ser Cys Phe Asn Pro Leu Asn Leu Asn Ile Ser Val Pro 115 120 125 Gly Asn Thr Asp Glu Ser Tyr Asp Cys Lys Val Phe Val Leu Thr Val 130 135 140 Leu Lys Gln Phe Ser Asn Cys Met Ala Glu Leu Gln Ala Lys Asp Asn 145 150 155 160 Thr Thr Cys < 210 > 62 < 211 > 16 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 16 ) < 223 > Variable heavy chain CDR - H 2 amino acid sequence of mouse antibody clone M 18 < 400 > 62 Tyr Ile Ser Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 63 < 211 > 15 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 15 ) < 223 > Variable light chain CDR - L 1 amino acid sequence of mouse antibody clone M 18 < 400 > 63 Arg Ala Ser Glu Ser Val Asp Thr Tyr Gly Asn Ser Phe Ile His 1 5 10 15 < 210 > 64 < 211 > 131 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 131 ) < 223 > Variable light chain amino acid sequence of mouse antibody clone M 18 < 400 > 64 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 20 25 30 Val Ser Pro Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 35 40 45 Val Asp Thr Tyr Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro 50 55 60 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 65 70 75 80 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 85 90 95 Leu Thr Ile Asn Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys 100 105 110 Gln Gln Ser Tyr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Lys 130 < 210 > 65 < 211 > 131 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 131 ) < 223 > Variable light chain amino acid sequence of mouse antibody clone M 19 < 400 > 65 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 20 25 30 Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 35 40 45 Val Asp Thr Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro 50 55 60 Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 65 70 75 80 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 85 90 95 Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Ile Ala Thr Tyr Tyr Cys 100 105 110 Gln Gln Ser Tyr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Lys 130 < 210 > 66 < 211 > 131 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 131 ) < 223 > Variable light chain amino acid sequence of mouse antibody clone M 87 < 400 > 66 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 20 25 30 Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser 35 40 45 Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro 50 55 60 Gly Gln Pro Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser 65 70 75 80 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 100 105 110 Gln His Ile Arg Glu Leu Thr Arg Ser Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Lys 130 < 210 > 67 < 211 > 137 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 137 ) < 223 > Variable heavy chain amino acid sequence of mouse antibody clone M 18 < 400 > 67 Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 1 5 10 15 Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys 20 25 30 Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile 35 40 45 Thr Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu 50 55 60 Glu Tyr Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro 65 70 75 80 Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 85 90 95 Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 100 105 110 Tyr Cys Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Ser Val Thr Val Ser Ser 130 135 < 210 > 68 < 211 > 137 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 137 ) < 223 > Variable heavy chain amino acid sequence of mouse antibody clone M 19 < 400 > 68 Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 1 5 10 15 Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys 20 25 30 Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile 35 40 45 Thr Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Glu Leu 50 55 60 Glu Tyr Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro 65 70 75 80 Ser Leu Lys Ser Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 85 90 95 Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 100 105 110 Tyr Cys Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Ser Val Thr Val Ser Ser 130 135 < 210 > 69 < 211 > 139 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 139 ) < 223 > Variable heavy chain amino acid sequence of mouse antibody clone M 87 < 400 > 69 Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 1 5 10 15 Val Leu Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 20 25 30 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 35 40 45 Thr Asp Tyr Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 50 55 60 Glu Trp Leu Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu 65 70 75 80 Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 85 90 95 Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser 100 105 110 Ala Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Gly Ser Cys Phe Asp Tyr 115 120 125 Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 130 135 < 210 > 70 < 211 > 25 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Caninized M 14 HC - FR 1 < 400 > 70 Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ser Val Thr 20 25 < 210 > 71 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Caninized M 14 HC - FR 2 < 400 > 71 Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met Gly 1 5 10 15 < 210 > 72 < 211 > 30 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Caninized M 14 HC - FR 3 < 400 > 72 Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu Gln 1 5 10 15 Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 20 25 30 < 210 > 73 < 211 > 36 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Alternate caninized M 14 HC - FR 3 < 400 > 73 Asn Pro Ser Leu Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys 1 5 10 15 Asn Gln Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 20 25 30 Thr Tyr Tyr Cys 35 < 210 > 74 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Caninized M 14 HC - FR 4 < 400 > 74 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 < 210 > 75 < 211 > 23 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Caninized M 14 LC - FR 1 < 400 > 75 Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys 20 < 210 > 76 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Caninized M 14 LC - FR 2 < 400 > 76 Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 1 5 10 15 < 210 > 77 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Caninized M 14 LC - FR 3 < 400 > 77 Gly Ile Pro Ala Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Asp Pro Val Gln Ala Asp Asp Val Ala Thr Tyr Tyr Cys 20 25 30 < 210 > 78 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Caninized M 14 LC - FR 4 < 400 > 78 Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 1 5 10 < 210 > 79 < 211 > 25 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Felinized M 14 HC - FR 1 < 400 > 79 Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ser Val Thr 20 25 < 210 > 80 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Felinized M 14 HC - FR 2 < 400 > 80 Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val Ala 1 5 10 15 < 210 > 81 < 211 > 37 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Felinized M 14 HC - FR 3 < 400 > 81 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 1 5 10 15 Asn Thr Leu Tyr Leu Gln Leu Asn Asn Leu Lys Ala Glu Asp Thr Ala 20 25 30 Thr Tyr Tyr Cys Ala 35 < 210 > 82 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Felinized M 14 HC - FR 4 < 400 > 82 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 < 210 > 83 < 211 > 23 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Felinized M 14 LC - FR 1 < 400 > 83 Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys 20 < 210 > 84 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Felinized M 14 LC - FR 2 < 400 > 84 Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 1 5 10 15 < 210 > 85 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Felinized M 14 LC - FR 3 < 400 > 85 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Thr Tyr Tyr Cys 20 25 30 < 210 > 86 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Felinized M 14 LC - FR 4 < 400 > 86 Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 1 5 10 < 210 > 87 < 211 > 10 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 10 ) < 223 > Alternate variable heavy chain CDR - H 2 amino acid sequence of mouse antibody clone M 18 < 400 > 87 Tyr Ile Ser Tyr Ser Gly Ile Thr Tyr Tyr 1 5 10 < 210 > 88 < 211 > 7 < 212 > PRT < 213 > Canidae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 7 ) < 223 > Alternative canine IL 31 epitope < 400 > 88 Pro Ser Asp Val Arg Lys Ile 1 5 < 210 > 89 < 211 > 10 < 212 > PRT < 213 > Murinae sp . < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 10 ) < 223 > Alternate variable heavy chain CDR - H 2 amino acid sequence of mouse antibody clones M 14 and M 19 < 400 > 89 Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr 1 5 10