신생아 패혈증 에서 발현 시기 에 따른 원인 균 분석 과 항생제 선택 
 June Seung Sung ( Sung JS ) , Dong Yeon Kim ( Kim DY ) , Sun Hee Kim ( Kim SH ) , Hyung Suk Byun ( Byun HS ) , Tai Ju Hwang ( Hwang TJ ) , Young Youn Choi ( Choi YY ) 
 June Seung Sung , Dong Yeon Kim , Sun Hee Kim , Hyung Suk Byun , Tai Ju Hwang , Young Youn Choi 
 Department of Pediatrics , Chonnam University Medical School 
 성 준승 , 김동연 , 김선희 , 변형석 , 황태주 , 최영륜 
 전남 대학교 의과 대학 소아 과학 교실 
 Correspondence : Young Youn Choi , 
 Email : yychoi @ chonnam . ac . kr 
 : The mortality rate of neonatal sepsis has been decreased , however , the incidence has not significantly decreased because of increased invasive procedures . This study was designed to make guidelines for choosing antibiotics by analyzing the causative microorganisms and their antibiotics sensitivity test according to the onset of neonatal sepsis . 
 : One hundred seven cases of culture proven sepsis in 89 patients admitted to the NICU of Chonnam University Hospital from Jan . 2000 to Dec . 2004 , were enrolled . By reviewing the medical records , clinical data , laboratory findings , causative organisms and their antibiotics sensitivity , and mortality were analyzed . 
 : The incidence of neonatal sepsis was 1 . 7 percent and more prevalent in premature and low birth weight infants . 85 . 4 percent of neonatal sepsis was late onset . Almost all microorganisms ( 92 . 9 percent ) were gram - positive in early onset , however , two thirds were gram - positive and one third were gram - negative and Candida in late onset . Gram - negative organisms and Candida were more prevalent in patients who had central line . Gram - positive organisms were sensitive to vancomycin , teicoplanin , and gram - negative were sensitive to imipenem , and cefotaxime . 
 : Neonatal sepsis was more prevalent in premature and low birth weight infants . More than 90 percent were gram - positive in early onset , however , one third was gram - negative and Candida in late onset . The first choice of antibiotics were a combination of third generation cephalosporin and clindamycin in early onset , and third generation cephalosporin and glycopeptide in late onset . If there is no response to antibiotics treatment , the use of antifungal agents should be considered . 
 Key Words : Neonatal sepsis , Early , Late , Antibiotics