SEQUENCE LISTING < 110 > NOVARTIS AG < 120 > IMPROVED FIBRONECTIN - BASED BINDING MOLECULES AND THEIR USE < 130 > PAT 052346 - WO - PCT < 140 > PCT / IB 2008 / 003962 < 141 > 2008 - 12 - 22 < 150 > 61 / 009 , " 361 < 151 > 2007 - 12 - 27 < 160 > 109 < 170 > PatentIn version 3 . 5 < 210 > 1 < 211 > 94 < 212 > PRT < 213 > Homo sapiens < 400 > 1 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 65 70 75 80 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 85 90 < 210 > 2 < 211 > 94 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 2 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Ala 65 70 75 80 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 85 90 < 210 > 3 < 211 > 94 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 3 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 65 70 75 80 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr 85 90 < 210 > 4 < 211 > 94 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 4 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 65 70 75 80 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr 85 90 < 210 > 5 < 211 > 19 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 5 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala < 210 > 6 < 211 > 110 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 6 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 85 90 95 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr 100 105 110 < 210 > 7 < 211 > 110 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 7 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Leu Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 85 90 95 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr 100 105 110 < 210 > 8 < 211 > 110 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 8 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 85 90 95 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 100 105 110 < 210 > 9 < 211 > 110 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 9 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Ala 85 90 95 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 100 105 110 < 210 > 10 < 211 > 115 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 10 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Asn Thr Asn Gly Leu Ile Thr Lys Tyr Pro Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Arg Ser Pro Ser Gly Phe Asn Arg Gly Gln Gly Thr Gln Val Thr 100 105 110 Val Ser Ser 115 < 210 > 11 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 11 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Asp Ser Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Leu Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Val Trp Arg Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 < 210 > 12 < 211 > 118 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 12 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Tyr 20 25 30 Asn Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Leu Pro His Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gln Asp Pro Leu Tyr Arg Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 < 210 > 13 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 13 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ile Lys His 20 25 30 Leu Lys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Arg Trp Pro Gln 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 < 210 > 14 < 211 > 585 < 212 > PRT < 213 > Homo sapiens < 400 > 14 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 1 5 10 15 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 20 25 30 Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 35 40 45 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 50 55 60 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 65 70 75 80 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 85 90 95 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 100 105 110 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 115 120 125 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 130 135 140 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 145 150 155 160 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 165 170 175 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 180 185 190 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 195 200 205 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 210 215 220 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 225 230 235 240 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 245 250 255 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 260 265 270 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 275 280 285 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 290 295 300 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 305 310 315 320 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 325 330 335 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 340 345 350 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 355 360 365 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 370 375 380 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 385 390 395 400 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 405 410 415 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 420 425 430 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 435 440 445 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 450 455 460 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 465 470 475 480 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 485 490 495 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 500 505 510 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 515 520 525 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 530 535 540 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 545 550 555 560 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 565 570 575 Ala Ala Ser Gln Ala Ala Leu Gly Leu 580 585 < 210 > 15 < 211 > 230 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 15 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 1 5 10 15 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 20 25 30 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 35 40 45 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 50 55 60 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 65 70 75 80 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 85 90 95 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 100 105 110 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 115 120 125 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 130 135 140 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 145 150 155 160 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 165 170 175 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 180 185 190 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 195 200 205 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 210 215 220 Ser Leu Ser Pro Gly Lys 225 230 < 210 > 16 < 211 > 32 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 16 gggcggaccg atgctcataa atctgaagtc gc 32 < 210 > 17 < 211 > 67 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 17 gggtttaaac tctagatcat caatgatgat gatgatggtg caaaccaagt gcggcctgac 60 tggccgc 67 < 210 > 18 < 211 > 34 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 18 cagactagat ctgtgagcga tgtgccgcgt gatc 34 < 210 > 19 < 211 > 75 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 19 cagactggat ccgccaccgc cgctgccacc accgccagaa ccgccaccac cggtgcgata 60 gttaatgctg atcgg 75 < 210 > 20 < 211 > 79 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 20 cagactggat ccgccaccgc cgctgccacc accgccagaa ccgccaccac cggtgcgata 60 gttaatgcta atcggtttg 79 < 210 > 21 < 211 > 34 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 21 cagactcata tggtgagcga tgtgccgcgt gatc 34 < 210 > 22 < 211 > 76 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 22 ctgactggat ccttaatggt gatgatgatg atgtgccgca gcacaagctg cagcggtgcg 60 atagttaatg ctgatc 76 < 210 > 23 < 211 > 76 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 23 ctgactggat ccttaatggt gatgatgatg atgtgccgca gcacaagctg cagcggtgcg 60 atagttaatg ctaatc 76 < 210 > 24 < 211 > 34 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 24 cagactggat ccgtgagcga tgtgccgcgt gatc 34 < 210 > 25 < 211 > 79 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 25 ctgactaagc tttcattaat ggtgatgatg atgatgtgcc gcagcacaag ctgcagcggt 60 gcgatagtta atgctgatc 79 < 210 > 26 < 211 > 79 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 26 ctgactaagc tttcattaat ggtgatgatg atgatgtgcc gcagcacaag ctgcagcggt 60 gcgatagtta atgctaatc 79 < 210 > 27 < 211 > 34 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 27 cagactcata tggtgagcga tgtgccgcgt gatc 34 < 210 > 28 < 211 > 76 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 28 ctgactggat ccttaatggt gatgatgatg atgtgccgca gcctaagctg cagcggtgcg 60 atagttaatg ctgatc 76 < 210 > 29 < 211 > 76 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 29 ctgactggat ccttaatggt gatgatgatg atgtgccgca gcctaagctg cagcggtgcg 60 atagttaatg ctaatc 76 < 210 > 30 < 211 > 34 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 30 cagactggat ccgtgagcga tgtgccgcgt gatc 34 < 210 > 31 < 211 > 79 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 31 ctgactaagc tttcattaat ggtgatgatg atgatgtgcc gcagcctaag ctgcagcggt 60 gcgatagtta atgctgatc 79 < 210 > 32 < 211 > 79 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 32 ctgactaagc tttcattaat ggtgatgatg atgatgtgcc gcagcctaag ctgcagcggt 60 gcgatagtta atgctaatc 79 < 210 > 33 < 211 > 39 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 33 gggcggaccg gcaaatcttg tgacaaaact cacacatgc 39 < 210 > 34 < 211 > 63 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 34 gggtttaaac tctagatcat caatgatgat gatgatggtg tttacccgga gacagggaga 60 ggc 63 < 210 > 35 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 35 Ser Gly Phe Thr Phe Ser Asp Tyr Trp Met 1 5 10 < 210 > 36 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 36 Arg Ser Pro Ser Gly Phe Asn Arg 1 5 < 210 > 37 < 211 > 101 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 37 Met Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 1 5 10 15 Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 20 25 30 Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 35 40 45 Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys 50 55 60 Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly 65 70 75 80 Ala Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr His 85 90 95 His His His His His 100 < 210 > 38 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 38 Ser Gln Ala Ile Asp Ser Tyr 1 5 < 210 > 39 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 39 Gln Val Val Trp Arg Pro Phe Thr 1 5 < 210 > 40 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 40 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Asp Ser Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Leu Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Val Trp Arg Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 < 210 > 41 < 211 > 96 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 41 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asp Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Trp Met Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 35 40 45 Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 50 55 60 Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Arg Ser Pro Ser Gly 65 70 75 80 Phe Asn Arg Ile Ser Ile Asn Tyr Arg Thr His His His His His His 85 90 95 < 210 > 42 < 211 > 88 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 42 Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala 1 5 10 15 Ser Gly Phe Thr Phe Ser Asp Tyr Trp Met Arg Ile Thr Tyr Gly Glu 20 25 30 Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys 35 40 45 Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile 50 55 60 Thr Val Tyr Arg Ser Pro Ser Gly Phe Asn Arg Ile Ser Ile Asn Tyr 65 70 75 80 Arg Thr His His His His His His 85 < 210 > 43 < 211 > 95 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 43 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asp Ala Ser Gln Ala Ile Asp Ser Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Gln Val Val Trp Arg Pro Phe 65 70 75 80 Thr Pro Ile Ser Ile Asn Tyr Arg Thr His His His His His His 85 90 95 < 210 > 44 < 211 > 87 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 44 Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala 1 5 10 15 Ser Gln Ala Ile Asp Ser Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 20 25 30 Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 35 40 45 Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 50 55 60 Tyr Gln Val Val Trp Arg Pro Phe Thr Pro Ile Ser Ile Asn Tyr Arg 65 70 75 80 Thr His His His His His His 85 < 210 > 45 < 400 > 45 000 < 210 > 46 < 400 > 46 000 < 210 > 47 < 400 > 47 000 < 210 > 48 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 48 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 65 70 75 80 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr Ala Ala 85 90 95 Ala Cys Ala Ala Ala His His His His His His 100 105 < 210 > 49 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 49 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 65 70 75 80 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr Ala Ala 85 90 95 Ala Cys Ala Ala Ala His His His His His His 100 105 < 210 > 50 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 50 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 65 70 75 80 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Ala Ala 85 90 95 Ala Cys Ala Ala Ala His His His His His His 100 105 < 210 > 51 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 51 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Ala 65 70 75 80 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Ala Ala 85 90 95 Ala Cys Ala Ala Ala His His His His His His 100 105 < 210 > 52 < 211 > 128 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 52 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu 35 40 45 Gln Ser Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Asp Lys Ser Asp Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Ala Ala Ala Cys Ala Ala Ala His His His His His His 115 120 125 < 210 > 53 < 211 > 128 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 53 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asn Arg Ser Gly Leu 35 40 45 Gln Ser Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Asp Lys Ser Asp Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Ala Ala Ala Cys Ala Ala Ala His His His His His His 115 120 125 < 210 > 54 < 211 > 128 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 54 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 35 40 45 Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Ala Ala Ala Cys Ala Ala Ala His His His His His His 115 120 125 < 210 > 55 < 211 > 128 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 55 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 35 40 45 Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Gly Arg Gly Ala Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Ala Ala Ala Cys Ala Ala Ala His His His His His His 115 120 125 < 210 > 56 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 220 > < 221 > MOD _ RES < 222 > ( 98 ) . .( 98 ) < 223 > Any non - natural amino acid < 220 > < 221 > misc _ feature < 222 > ( 98 ) . .( 98 ) < 223 > / note ="" See specification as filed for detailed description of substitutions and preferred embodiments "" < 400 > 56 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 65 70 75 80 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr Ala Ala 85 90 95 Ala Xaa Ala Ala Ala His His His His His His 100 105 < 210 > 57 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 220 > < 221 > MOD _ RES < 222 > ( 98 ) . .( 98 ) < 223 > Any non - natural amino acid < 220 > < 221 > misc _ feature < 222 > ( 98 ) . .( 98 ) < 223 > / note ="" See specification as filed for detailed description of substitutions and preferred embodiments "" < 400 > 57 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 65 70 75 80 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr Ala Ala 85 90 95 Ala Xaa Ala Ala Ala His His His His His His 100 105 < 210 > 58 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 220 > < 221 > MOD _ RES < 222 > ( 98 ) . .( 98 ) < 223 > Any non - natural amino acid < 220 > < 221 > misc _ feature < 222 > ( 98 ) . .( 98 ) < 223 > / note ="" See specification as filed for detailed description of substitutions and preferred embodiments "" < 400 > 58 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 65 70 75 80 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Ala Ala 85 90 95 Ala Xaa Ala Ala Ala His His His His His His 100 105 < 210 > 59 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 220 > < 221 > MOD _ RES < 222 > ( 98 ) . .( 98 ) < 223 > Any non - natural amino acid < 220 > < 221 > misc _ feature < 222 > ( 98 ) . .( 98 ) < 223 > / note ="" See specification as filed for detailed description of substitutions and preferred embodiments "" < 400 > 59 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 20 25 30 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Ala 65 70 75 80 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Ala Ala 85 90 95 Ala Xaa Ala Ala Ala His His His His His His 100 105 < 210 > 60 < 211 > 128 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 220 > < 221 > MOD _ RES < 222 > ( 119 ) . .( 119 ) < 223 > Any non - natural amino acid < 220 > < 221 > misc _ feature < 222 > ( 119 ) . .( 119 ) < 223 > / note ="" See specification as filed for detailed description of substitutions and preferred embodiments "" < 400 > 60 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu 35 40 45 Gln Ser Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Asp Lys Ser Asp Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Ala Ala Ala Xaa Ala Ala Ala His His His His His His 115 120 125 < 210 > 61 < 211 > 128 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 220 > < 221 > MOD _ RES < 222 > ( 119 ) . .( 119 ) < 223 > Any non - natural amino acid < 220 > < 221 > misc _ feature < 222 > ( 119 ) . .( 119 ) < 223 > / note ="" See specification as filed for detailed description of substitutions and preferred embodiments "" < 400 > 61 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asn Arg Ser Gly Leu 35 40 45 Gln Ser Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Asp Lys Ser Asp Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Ala Ala Ala Xaa Ala Ala Ala His His His His His His 115 120 125 < 210 > 62 < 211 > 128 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 220 > < 221 > MOD _ RES < 222 > ( 119 ) . .( 119 ) < 223 > Any non - natural amino acid < 220 > < 221 > misc _ feature < 222 > ( 119 ) . .( 119 ) < 223 > / note ="" See specification as filed for detailed description of substitutions and preferred embodiments "" < 400 > 62 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 35 40 45 Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Ala Ala Ala Xaa Ala Ala Ala His His His His His His 115 120 125 < 210 > 63 < 211 > 128 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 220 > < 221 > MOD _ RES < 222 > ( 119 ) . .( 119 ) < 223 > Any non - natural amino acid < 220 > < 221 > misc _ feature < 222 > ( 119 ) . .( 119 ) < 223 > / note ="" See specification as filed for detailed description of substitutions and preferred embodiments "" < 400 > 63 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 35 40 45 Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Gly Arg Gly Ala Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Ala Ala Ala Xaa Ala Ala Ala His His His His His His 115 120 125 < 210 > 64 < 211 > 254 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 64 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu 35 40 45 Gln Ser Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Asp Lys Ser Asp Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 145 150 155 160 Glu Tyr Asn Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 165 170 175 Trp Val Ser Thr Ile Leu Pro His Gly Asp Arg Thr Tyr Tyr Ala Asp 180 185 190 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 195 200 205 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 210 215 220 Tyr Cys Ala Lys Gln Asp Pro Leu Tyr Arg Phe Asp Tyr Trp Gly Gln 225 230 235 240 Gly Thr Leu Val Thr Val Ser Ser His His His His His His 245 250 < 210 > 65 < 211 > 254 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 65 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asn Arg Ser Gly Leu 35 40 45 Gln Ser Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Asp Lys Ser Asp Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 145 150 155 160 Glu Tyr Asn Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 165 170 175 Trp Val Ser Thr Ile Leu Pro His Gly Asp Arg Thr Tyr Tyr Ala Asp 180 185 190 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 195 200 205 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 210 215 220 Tyr Cys Ala Lys Gln Asp Pro Leu Tyr Arg Phe Asp Tyr Trp Gly Gln 225 230 235 240 Gly Thr Leu Val Thr Val Ser Ser His His His His His His 245 250 < 210 > 66 < 211 > 254 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 66 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 35 40 45 Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 145 150 155 160 Glu Tyr Asn Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 165 170 175 Trp Val Ser Thr Ile Leu Pro His Gly Asp Arg Thr Tyr Tyr Ala Asp 180 185 190 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 195 200 205 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 210 215 220 Tyr Cys Ala Lys Gln Asp Pro Leu Tyr Arg Phe Asp Tyr Trp Gly Gln 225 230 235 240 Gly Thr Leu Val Thr Val Ser Ser His His His His His His 245 250 < 210 > 67 < 211 > 254 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 67 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 35 40 45 Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Gly Arg Gly Ala Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 145 150 155 160 Glu Tyr Asn Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 165 170 175 Trp Val Ser Thr Ile Leu Pro His Gly Asp Arg Thr Tyr Tyr Ala Asp 180 185 190 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 195 200 205 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 210 215 220 Tyr Cys Ala Lys Gln Asp Pro Leu Tyr Arg Phe Asp Tyr Trp Gly Gln 225 230 235 240 Gly Thr Leu Val Thr Val Ser Ser His His His His His His 245 250 < 210 > 68 < 211 > 244 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 68 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu 35 40 45 Gln Ser Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Asp Lys Ser Asp Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ile 145 150 155 160 Lys His Leu Lys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Arg Trp 210 215 220 Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg His His 225 230 235 240 His His His His < 210 > 69 < 211 > 244 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 69 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asn Arg Ser Gly Leu 35 40 45 Gln Ser Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Asp Lys Ser Asp Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ile 145 150 155 160 Lys His Leu Lys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Arg Trp 210 215 220 Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg His His 225 230 235 240 His His His His < 210 > 70 < 211 > 244 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 70 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 35 40 45 Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ile 145 150 155 160 Lys His Leu Lys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Arg Trp 210 215 220 Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg His His 225 230 235 240 His His His His < 210 > 71 < 211 > 244 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 71 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 35 40 45 Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Gly Arg Gly Ala Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ile 145 150 155 160 Lys His Leu Lys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Arg Trp 210 215 220 Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg His His 225 230 235 240 His His His His < 210 > 72 < 211 > 347 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 72 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 85 90 95 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr Gly Lys 100 105 110 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 115 120 125 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 130 135 140 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 145 150 155 160 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 165 170 175 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 180 185 190 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 195 200 205 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 210 215 220 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 225 230 235 240 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 245 250 255 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 260 265 270 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 275 280 285 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 290 295 300 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 305 310 315 320 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 325 330 335 Leu Ser Pro Gly Lys His His His His His His 340 345 < 210 > 73 < 211 > 347 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 73 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Leu Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 85 90 95 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr Gly Lys 100 105 110 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 115 120 125 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 130 135 140 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 145 150 155 160 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 165 170 175 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 180 185 190 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 195 200 205 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 210 215 220 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 225 230 235 240 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 245 250 255 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 260 265 270 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 275 280 285 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 290 295 300 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 305 310 315 320 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 325 330 335 Leu Ser Pro Gly Lys His His His His His His 340 345 < 210 > 74 < 211 > 347 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 74 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 85 90 95 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Gly Lys 100 105 110 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 115 120 125 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 130 135 140 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 145 150 155 160 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 165 170 175 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 180 185 190 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 195 200 205 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 210 215 220 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 225 230 235 240 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 245 250 255 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 260 265 270 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 275 280 285 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 290 295 300 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 305 310 315 320 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 325 330 335 Leu Ser Pro Gly Lys His His His His His His 340 345 < 210 > 75 < 211 > 347 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 75 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Ala 85 90 95 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Gly Lys 100 105 110 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 115 120 125 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 130 135 140 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 145 150 155 160 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 165 170 175 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 180 185 190 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 195 200 205 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 210 215 220 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 225 230 235 240 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 245 250 255 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 260 265 270 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 275 280 285 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 290 295 300 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 305 310 315 320 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 325 330 335 Leu Ser Pro Gly Lys His His His His His His 340 345 < 210 > 76 < 211 > 87 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 76 Gly Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Arg 1 5 10 15 His Pro His Phe Pro Thr Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr 20 25 30 Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Leu Gln Pro Pro 35 40 45 Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 50 55 60 Val Tyr Ala Val Thr Asp Gly Arg Asn Gly Arg Leu Leu Ser Ile Pro 65 70 75 80 Ile Ser Ile Asn Tyr Arg Thr 85 < 210 > 77 < 211 > 103 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 77 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Gly Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Arg 20 25 30 His Pro His Phe Pro Thr Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr 35 40 45 Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Leu Gln Pro Pro 50 55 60 Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 65 70 75 80 Val Tyr Ala Val Thr Asp Gly Arg Asn Gly Arg Leu Leu Ser Ile Pro 85 90 95 Ile Ser Ile Asn Tyr Arg Thr 100 < 210 > 78 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 78 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Asn Ser Pro Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Arg Val Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 < 210 > 79 < 211 > 584 < 212 > PRT < 213 > Rattus norvegicus < 400 > 79 Glu Ala His Lys Ser Glu Ile Ala His Arg Phe Lys Asp Leu Gly Glu 1 5 10 15 Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 20 25 30 Lys Cys Pro Tyr Glu Glu His Ile Lys Leu Val Gln Glu Val Thr Asp 35 40 45 Phe Ala Lys Thr Cys Val Ala Asp Glu Asn Ala Glu Asn Cys Asp Lys 50 55 60 Ser Ile His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Lys Leu 65 70 75 80 Arg Asp Asn Tyr Gly Glu Leu Ala Asp Cys Cys Ala Lys Gln Glu Pro 85 90 95 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 100 105 110 Pro Pro Phe Gln Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Gln 115 120 125 Glu Asn Pro Thr Ser Phe Leu Gly His Tyr Leu His Glu Val Ala Arg 130 135 140 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Lys 145 150 155 160 Tyr Asn Glu Val Leu Thr Gln Cys Cys Thr Glu Ser Asp Lys Ala Ala 165 170 175 Cys Leu Thr Pro Lys Leu Asp Ala Val Lys Glu Lys Ala Leu Val Ala 180 185 190 Ala Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Arg Phe Gly Glu 195 200 205 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Met Ser Gln Arg Phe Pro 210 215 220 Asn Ala Glu Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Val Thr Lys 225 230 235 240 Ile Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 245 250 255 Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 260 265 270 Ser Lys Leu Gln Ala Cys Cys Asp Lys Pro Val Leu Gln Lys Ser Gln 275 280 285 Cys Leu Ala Glu Ile Glu His Asp Asn Ile Pro Ala Asp Leu Pro Ser 290 295 300 Ile Ala Ala Asp Phe Val Glu Asp Lys Glu Val Cys Lys Asn Tyr Ala 305 310 315 320 Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 325 330 335 Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 340 345 350 Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Gly Asp Pro Pro Ala 355 360 365 Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 370 375 380 Lys Asn Leu Val Lys Thr Asn Cys Glu Leu Tyr Glu Lys Leu Gly Glu 385 390 395 400 Tyr Gly Phe Gln Asn Ala Val Leu Val Arg Tyr Thr Gln Lys Ala Pro 405 410 415 Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 420 425 430 Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Ala Gln Arg Leu Pro Cys 435 440 445 Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Leu Cys Val Leu His 450 455 460 Glu Lys Thr Pro Val Ser Glu Lys Val Thr Lys Cys Cys Ser Gly Ser 465 470 475 480 Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 485 490 495 Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 500 505 510 Ile Cys Thr Leu Pro Asp Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 515 520 525 Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Glu Asp Gln Leu 530 535 540 Lys Thr Val Met Gly Asp Phe Ala Gln Phe Val Asp Lys Cys Cys Lys 545 550 555 560 Ala Ala Asp Lys Asp Asn Cys Phe Ala Thr Glu Gly Pro Asn Leu Val 565 570 575 Ala Arg Ser Lys Glu Ala Leu Ala 580 < 210 > 80 < 211 > 51 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 80 cgtgcgagcc agagcattag ctcttacctg aactggtatc agcagaaacc g 51 < 210 > 81 < 211 > 51 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 81 cggtttctgc tgataccagt tcaggtaaga gctaatgctc tggctcgcac g 51 < 210 > 82 < 211 > 46 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 82 cgaaactgct gatttatcgc aacagcccgc tgcagagcgg tgtgcc 46 < 210 > 83 < 211 > 46 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 83 ggcacaccgc tctgcagcgg gctgttgcga taaatcagca gtttcg 46 < 210 > 84 < 211 > 53 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 84 cctattattg ccagcagact taccgtgttc cgccgacctt tggccagggc acc 53 < 210 > 85 < 211 > 53 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 85 ggtgccctgg ccaaaggtcg gcggaacacg gtaagtctgc tggcaataat agg 53 < 210 > 86 < 211 > 32 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 86 gggcggaccg aagcacacaa gagtgagatc gc 32 < 210 > 87 < 211 > 70 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 87 gggtttaaac gggccctcta gatcatcaat gatgatgatg atggtgggct aaggcttctt 60 tgcttctagc 70 < 210 > 88 < 211 > 35 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 88 atggattcca aaacgccgtt ctggttcgat acacc 35 < 210 > 89 < 211 > 35 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 89 ggtgtatcga accagaacgg cgttttggaa tccat 35 < 210 > 90 < 211 > 37 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 90 accaaattgg caacagacgt caccaaaatc aacaagg 37 < 210 > 91 < 211 > 37 < 212 > DNA < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic primer "" < 400 > 91 ccttgttgat tttggtgacg tctgttgcca atttggt 37 < 210 > 92 < 211 > 244 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 92 Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 1 5 10 15 Ala Ser Ala Gly Ser Val Ser Asp Val Pro Arg Asp Leu Glu Val Val 20 25 30 Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 35 40 45 Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser 50 55 60 Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 65 70 75 80 Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val 85 90 95 Thr Gly Arg Gly Ala Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn 100 105 110 Tyr Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 145 150 155 160 Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Arg Asn Ser Pro Leu Gln Ser Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Arg Val 210 215 220 Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg His His 225 230 235 240 His His His His < 210 > 93 < 400 > 93 000 < 210 > 94 < 400 > 94 000 < 210 > 95 < 400 > 95 000 < 210 > 96 < 211 > 701 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 96 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 85 90 95 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr Asp Ala 100 105 110 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 115 120 125 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys 130 135 140 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 145 150 155 160 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 165 170 175 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 180 185 190 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 195 200 205 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 210 215 220 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 225 230 235 240 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 245 250 255 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 260 265 270 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 275 280 285 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 290 295 300 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 305 310 315 320 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 325 330 335 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 340 345 350 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 355 360 365 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 370 375 380 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 385 390 395 400 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 405 410 415 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 420 425 430 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 435 440 445 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 450 455 460 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 465 470 475 480 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 485 490 495 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 500 505 510 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 515 520 525 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 530 535 540 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 545 550 555 560 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 565 570 575 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 580 585 590 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 595 600 605 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 610 615 620 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 625 630 635 640 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 645 650 655 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 660 665 670 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 675 680 685 Ser Gln Ala Ala Leu Gly Leu His His His His His His 690 695 700 < 210 > 97 < 211 > 701 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 97 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Leu Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp 85 90 95 Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr Asp Ala 100 105 110 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 115 120 125 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys 130 135 140 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 145 150 155 160 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 165 170 175 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 180 185 190 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 195 200 205 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 210 215 220 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 225 230 235 240 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 245 250 255 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 260 265 270 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 275 280 285 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 290 295 300 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 305 310 315 320 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 325 330 335 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 340 345 350 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 355 360 365 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 370 375 380 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 385 390 395 400 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 405 410 415 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 420 425 430 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 435 440 445 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 450 455 460 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 465 470 475 480 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 485 490 495 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 500 505 510 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 515 520 525 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 530 535 540 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 545 550 555 560 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 565 570 575 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 580 585 590 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 595 600 605 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 610 615 620 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 625 630 635 640 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 645 650 655 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 660 665 670 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 675 680 685 Ser Gln Ala Ala Leu Gly Leu His His His His His His 690 695 700 < 210 > 98 < 211 > 701 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 98 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Arg Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Gly Ser Lys Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 85 90 95 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Asp Ala 100 105 110 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 115 120 125 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys 130 135 140 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 145 150 155 160 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 165 170 175 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 180 185 190 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 195 200 205 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 210 215 220 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 225 230 235 240 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 245 250 255 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 260 265 270 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 275 280 285 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 290 295 300 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 305 310 315 320 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 325 330 335 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 340 345 350 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 355 360 365 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 370 375 380 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 385 390 395 400 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 405 410 415 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 420 425 430 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 435 440 445 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 450 455 460 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 465 470 475 480 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 485 490 495 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 500 505 510 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 515 520 525 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 530 535 540 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 545 550 555 560 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 565 570 575 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 580 585 590 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 595 600 605 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 610 615 620 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 625 630 635 640 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 645 650 655 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 660 665 670 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 675 680 685 Ser Gln Ala Ala Leu Gly Leu His His His His His His 690 695 700 < 210 > 99 < 211 > 701 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 99 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Arg Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Gly Ser Lys Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Ala 85 90 95 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Asp Ala 100 105 110 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 115 120 125 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys 130 135 140 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 145 150 155 160 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 165 170 175 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 180 185 190 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 195 200 205 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 210 215 220 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 225 230 235 240 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 245 250 255 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 260 265 270 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 275 280 285 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 290 295 300 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 305 310 315 320 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 325 330 335 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 340 345 350 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 355 360 365 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 370 375 380 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 385 390 395 400 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 405 410 415 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 420 425 430 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 435 440 445 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 450 455 460 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 465 470 475 480 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 485 490 495 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 500 505 510 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 515 520 525 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 530 535 540 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 545 550 555 560 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 565 570 575 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 580 585 590 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 595 600 605 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 610 615 620 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 625 630 635 640 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 645 650 655 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 660 665 670 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 675 680 685 Ser Gln Ala Ala Leu Gly Leu His His His His His His 690 695 700 < 210 > 100 < 211 > 700 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 100 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 20 25 30 Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 35 40 45 Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 50 55 60 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 65 70 75 80 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Ala 85 90 95 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ala 100 105 110 His Lys Ser Glu Ile Ala His Arg Phe Lys Asp Leu Gly Glu Gln His 115 120 125 Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys 130 135 140 Pro Tyr Glu Glu His Ile Lys Leu Val Gln Glu Val Thr Asp Phe Ala 145 150 155 160 Lys Thr Cys Val Ala Asp Glu Asn Ala Glu Asn Cys Asp Lys Ser Ile 165 170 175 His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Lys Leu Arg Asp 180 185 190 Asn Tyr Gly Glu Leu Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 195 200 205 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Pro 210 215 220 Phe Gln Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Gln Glu Asn 225 230 235 240 Pro Thr Ser Phe Leu Gly His Tyr Leu His Glu Val Ala Arg Arg His 245 250 255 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Lys Tyr Asn 260 265 270 Glu Val Leu Thr Gln Cys Cys Thr Glu Ser Asp Lys Ala Ala Cys Leu 275 280 285 Thr Pro Lys Leu Asp Ala Val Lys Glu Lys Ala Leu Val Ala Ala Val 290 295 300 Arg Gln Arg Met Lys Cys Ser Ser Met Gln Arg Phe Gly Glu Arg Ala 305 310 315 320 Phe Lys Ala Trp Ala Val Ala Arg Met Ser Gln Arg Phe Pro Asn Ala 325 330 335 Glu Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Val Thr Lys Ile Asn 340 345 350 Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 355 360 365 Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser Ser Lys 370 375 380 Leu Gln Ala Cys Cys Asp Lys Pro Val Leu Gln Lys Ser Gln Cys Leu 385 390 395 400 Ala Glu Ile Glu His Asp Asn Ile Pro Ala Asp Leu Pro Ser Ile Ala 405 410 415 Ala Asp Phe Val Glu Asp Lys Glu Val Cys Lys Asn Tyr Ala Glu Ala 420 425 430 Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg Arg His 435 440 445 Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys Tyr Glu 450 455 460 Ala Thr Leu Glu Lys Cys Cys Ala Glu Gly Asp Pro Pro Ala Cys Tyr 465 470 475 480 Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro Lys Asn 485 490 495 Leu Val Lys Thr Asn Cys Glu Leu Tyr Glu Lys Leu Gly Glu Tyr Gly 500 505 510 Phe Gln Asn Ala Val Leu Val Arg Tyr Thr Gln Lys Ala Pro Gln Val 515 520 525 Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg Val Gly 530 535 540 Thr Lys Cys Cys Thr Leu Pro Glu Ala Gln Arg Leu Pro Cys Val Glu 545 550 555 560 Asp Tyr Leu Ser Ala Ile Leu Asn Arg Leu Cys Val Leu His Glu Lys 565 570 575 Thr Pro Val Ser Glu Lys Val Thr Lys Cys Cys Ser Gly Ser Leu Val 580 585 590 Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr Tyr Val 595 600 605 Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp Ile Cys 610 615 620 Thr Leu Pro Asp Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala Leu Ala 625 630 635 640 Glu Leu Val Lys His Lys Pro Lys Ala Thr Glu Asp Gln Leu Lys Thr 645 650 655 Val Met Gly Asp Phe Ala Gln Phe Val Asp Lys Cys Cys Lys Ala Ala 660 665 670 Asp Lys Asp Asn Cys Phe Ala Thr Glu Gly Pro Asn Leu Val Ala Arg 675 680 685 Ser Lys Glu Ala Leu Ala His His His His His His 690 695 700 < 210 > 101 < 211 > 694 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 101 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Gly Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Arg 20 25 30 His Pro His Phe Pro Thr Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr 35 40 45 Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Leu Gln Pro Pro 50 55 60 Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 65 70 75 80 Val Tyr Ala Val Thr Asp Gly Arg Asn Gly Arg Leu Leu Ser Ile Pro 85 90 95 Ile Ser Ile Asn Tyr Arg Thr Asp Ala His Lys Ser Glu Val Ala His 100 105 110 Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 115 120 125 Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys 130 135 140 Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 145 150 155 160 Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 165 170 175 Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 180 185 190 Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 195 200 205 Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 210 215 220 Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 225 230 235 240 Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 245 250 255 Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 260 265 270 Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 275 280 285 Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 290 295 300 Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 305 310 315 320 Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 325 330 335 Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 340 345 350 Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 355 360 365 Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 370 375 380 Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 385 390 395 400 Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 405 410 415 Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 420 425 430 Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 435 440 445 Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 450 455 460 Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 465 470 475 480 Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 485 490 495 Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 500 505 510 Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 515 520 525 Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 530 535 540 Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 545 550 555 560 Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 565 570 575 Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 580 585 590 Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu 595 600 605 Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 610 615 620 Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 625 630 635 640 Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 645 650 655 Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 660 665 670 Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 675 680 685 His His His His His His 690 < 210 > 102 < 211 > 693 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 102 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Gly Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Arg 20 25 30 His Pro His Phe Pro Thr Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr 35 40 45 Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Leu Gln Pro Pro 50 55 60 Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 65 70 75 80 Val Tyr Ala Val Thr Asp Gly Arg Asn Gly Arg Leu Leu Ser Ile Pro 85 90 95 Ile Ser Ile Asn Tyr Arg Thr Glu Ala His Lys Ser Glu Ile Ala His 100 105 110 Arg Phe Lys Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile 115 120 125 Ala Phe Ser Gln Tyr Leu Gln Lys Cys Pro Tyr Glu Glu His Ile Lys 130 135 140 Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu 145 150 155 160 Asn Ala Glu Asn Cys Asp Lys Ser Ile His Thr Leu Phe Gly Asp Lys 165 170 175 Leu Cys Ala Ile Pro Lys Leu Arg Asp Asn Tyr Gly Glu Leu Ala Asp 180 185 190 Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 195 200 205 Lys Asp Asp Asn Pro Asn Leu Pro Pro Phe Gln Arg Pro Glu Ala Glu 210 215 220 Ala Met Cys Thr Ser Phe Gln Glu Asn Pro Thr Ser Phe Leu Gly His 225 230 235 240 Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 245 250 255 Leu Leu Tyr Tyr Ala Glu Lys Tyr Asn Glu Val Leu Thr Gln Cys Cys 260 265 270 Thr Glu Ser Asp Lys Ala Ala Cys Leu Thr Pro Lys Leu Asp Ala Val 275 280 285 Lys Glu Lys Ala Leu Val Ala Ala Val Arg Gln Arg Met Lys Cys Ser 290 295 300 Ser Met Gln Arg Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 305 310 315 320 Arg Met Ser Gln Arg Phe Pro Asn Ala Glu Phe Ala Glu Ile Thr Lys 325 330 335 Leu Ala Thr Asp Val Thr Lys Ile Asn Lys Glu Cys Cys His Gly Asp 340 345 350 Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys 355 360 365 Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Ala Cys Cys Asp Lys 370 375 380 Pro Val Leu Gln Lys Ser Gln Cys Leu Ala Glu Ile Glu His Asp Asn 385 390 395 400 Ile Pro Ala Asp Leu Pro Ser Ile Ala Ala Asp Phe Val Glu Asp Lys 405 410 415 Glu Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Thr 420 425 430 Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser Leu 435 440 445 Leu Leu Arg Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys Cys 450 455 460 Ala Glu Gly Asp Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu Phe 465 470 475 480 Gln Pro Leu Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys Glu 485 490 495 Leu Tyr Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Val Leu Val 500 505 510 Arg Tyr Thr Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val Glu 515 520 525 Ala Ala Arg Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu Pro 530 535 540 Glu Ala Gln Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile Leu 545 550 555 560 Asn Arg Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Glu Lys Val 565 570 575 Thr Lys Cys Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe Ser 580 585 590 Ala Leu Thr Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala Glu 595 600 605 Thr Phe Thr Phe His Ser Asp Ile Cys Thr Leu Pro Asp Lys Glu Lys 610 615 620 Gln Ile Lys Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys Pro 625 630 635 640 Lys Ala Thr Glu Asp Gln Leu Lys Thr Val Met Gly Asp Phe Ala Gln 645 650 655 Phe Val Asp Lys Cys Cys Lys Ala Ala Asp Lys Asp Asn Cys Phe Ala 660 665 670 Thr Glu Gly Pro Asn Leu Val Ala Arg Ser Lys Glu Ala Leu Ala His 675 680 685 His His His His His 690 < 210 > 103 < 211 > 96 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic polypeptide "" < 400 > 103 Met Gln Val Ser Asp Val Pro Thr Asp Leu Glu Val Val Ala Ala Thr 1 5 10 15 Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 20 25 30 Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 35 40 45 Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 50 55 60 Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg 65 70 75 80 Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 85 90 95 < 210 > 104 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 104 Ile Lys His Leu Lys 1 5 < 210 > 105 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 105 Ser Ser Tyr Leu Asn 1 5 < 210 > 106 < 211 > 4 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 106 Gly Ala Ser Arg 1 < 210 > 107 < 211 > 4 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 107 Arg Asn Ser Pro 1 < 210 > 108 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 108 Gly Ala Arg Trp Pro Gln 1 5 < 210 > 109 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 221 > source < 223 > / note ="" Description of Artificial Sequence : Synthetic peptide "" < 400 > 109 Thr Tyr Arg Val Pro Pro 1 5 "