It ' s hard to analyze other people when your just in a empty white room and you know 0 things about any other people , making fun of someone like house for being disabled is just a face level quip without any context backing it . Sheldon would know every single other character down to the most mundane details and every single thing they have every done as well as every single version of them ever made . It wouldn ' t an initial advantage , it would win him the prompt since he has the advantage of being able to smack talk and say anything any other character have ever done at any time . While at best all of the other characters can only quip about face value impressions of other characters . He has the holy bible to make quips on every single other character in the series since it has been literally already done for him . That ' s what I mean when he ' s too meta . For example what can House say about Sheldon ? Nothing really other then he ' s a weird nerd , while sheldon can quip about the entire history and every single intimate and mistake house has ever made on within his universe .