< 110 > Roche Glycart AG < 120 > Anti - FAP Antibodies and Methods of Use < 130 > 26953 < 140 > PCT / EP 2011 / 063648 < 141 > 2011 - 08 - 09 < 150 > EP 10172842 . 6 < 151 > 2010 - 08 - 13 < 160 > 352 < 170 > PatentIn version 3 . 5 < 210 > 1 < 211 > 1611 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Library Template for DP 47 - 3 library < 400 > 1 atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc 60 atggccgaaa tcgtgttaac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 120 gccaccctct cttgcagggc cagtcagagt gttagcagca gctacttagc ctggtaccag 180 cagaaacctg gccaggctcc caggctcctc atctatggag catccagcag ggccactggc 240 atcccagaca ggttcagtgg cagtggatcc gggacagact tcactctcac catcagcaga 300 ctggagcctg aagattttgc agtgtattac tgtcagcagt atggtagctc accgctgacg 360 ttcggccagg ggaccaaagt ggaaatcaaa cgtacggtgg ctgcaccatc tgtcttcatc 420 ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat 480 aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt 540 aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc 600 accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc 660 catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg tggagccgca 720 gaacaaaaac tcatctcaga agaggatctg aatggagccg cagactacaa ggacgacgac 780 gacaagggtg ccgcataata aggcgcgcca attctatttc aaggagacag tcatatgaaa 840 tacctgctgc cgaccgctgc tgctggtctg ctgctcctcg ctgcccagcc ggcgatggcc 900 gaggtgcaat tgctggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 960 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 1020 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 1080 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 1140 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaccgttt 1200 ccgtattttg actactgggg ccaaggaacc ctggtcaccg tctcgagtgc tagcaccaaa 1260 ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1320 ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1380 gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1440 ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1500 gtgaatcaca agcccagcaa caccaaagtg gacaagaaag ttgagcccaa atcttgtgac 1560 gcggccgcaa gcactagtgc ccatcaccat caccatcacg ccgcggcata g 1611 < 210 > 2 < 211 > 1617 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Library Template for DP 88 - 3 library < 400 > 2 atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc 60 atggccgata tccagatgac ccagtctcca tcctccctgt ctgcatctgt cggagaccgg 120 gtcaccatca cctgccgggc aagtcagggc attagaaatg atttaggctg gtaccagcag 180 aagccaggga aagcccctaa gcgcctgatc tatgctgcat ccagtttgca gagtggcgtc 240 ccatcaaggt tcagcggcag tggatccggg acagagttca ctctcaccat cagcagcttg 300 cagcctgaag attttgccac ctattactgc ttgcagcata atagttaccc cacgtttggc 360 cagggcacca aagtcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg 420 ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 480 tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 540 caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 600 acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 660 ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagc cgcagaacaa 720 aaactcatct cagaagagga tctgaatgga gccgcagact acaaggacga cgacgacaag 780 ggtgccgcat aataaggcgc gccaattcta tttcaaggag acagtcatat gaaatacctg 840 ctgccgaccg ctgctgctgg tctgctgctc ctcgctgccc agccggcgat ggcccaggtg 900 caattggtgc agtctggggc tgaggtgaag aagcctgggt cctcggtgaa ggtctcctgc 960 aaggcctccg gaggcacatt cagcagctac gctataagct gggtgcgaca ggcccctgga 1020 caagggctcg agtggatggg agggatcatc cctatctttg gtacagcaaa ctacgcacag 1080 aagttccagg gcagggtcac cattactgca gacaaatcca cgagcacagc ctacatggag 1140 ctgagcagcc tgagatctga ggacaccgcc gtgtattact gtgcgagact atccccaggc 1200 ggttactatg ttatggatgc ctggggccaa gggaccaccg tgaccgtctc ctcagctagc 1260 accaaaggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 1320 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 1380 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 1440 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 1500 tgcaacgtga atcacaagcc cagcaacacc aaagtggaca agaaagttga gcccaaatct 1560 tgtgacgcgg ccgcaagcac tagtgcccat caccatcacc atcacgccgc ggcatag 1617 < 210 > 3 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 1 ) < 400 > 3 Ser Tyr Ala Met Ser 1 5 < 210 > 4 < 211 > 15 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 1 ) ( DNA 1 ) < 400 > 4 agttatgcca tgagc 15 < 210 > 5 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 2 ) < 400 > 5 Ser Tyr Thr Met Ser 1 5 < 210 > 6 < 211 > 15 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 2 ) ( DNA ) < 400 > 6 agttatacca tgagc 15 < 210 > 7 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 3 ) < 400 > 7 Ser Phe Ala Met Ser 1 5 < 210 > 8 < 211 > 15 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 3 ) ( DNA ) < 400 > 8 agttttgcca tgagc 15 < 210 > 9 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 4 ) < 400 > 9 Ser His Ala Met Ser 1 5 < 210 > 10 < 211 > 15 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 4 ) ( DNA ) < 400 > 10 agtcatgcta tgagc 15 < 210 > 11 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 5 ) < 400 > 11 Ser Ser Ala Met Ser 1 5 < 210 > 12 < 211 > 15 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 5 ) ( DNA ) < 400 > 12 agttctgcca tgagc 15 < 210 > 13 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Chothia ( 1 ) < 400 > 13 Gly Phe Thr Phe Ser Ser Tyr 1 5 < 210 > 14 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Chothia ( 1 ) ( DNA ) < 400 > 14 ggattcacct ttagcagtta t 21 < 210 > 15 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Chothia ( 2 ) < 400 > 15 Gly Ser Thr Phe Ser Ser Tyr 1 5 < 210 > 16 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Chothia ( 2 ) ( DNA ) < 400 > 16 ggatccacct ttagcagtta t 21 < 210 > 17 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Chothia ( 3 ) < 400 > 17 Gly Phe Thr Phe Ser Ser Phe 1 5 < 210 > 18 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Chothia ( 3 ) ( DNA ) < 400 > 18 ggattcacct ttagcagttt t 21 < 210 > 19 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Chothia ( 4 ) < 400 > 19 Gly Phe Thr Phe Ser Ser His 1 5 < 210 > 20 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Chothia ( 4 ) ( DNA ) < 400 > 20 ggattcacct ttagcagtca t 21 < 210 > 21 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Chothia ( 5 ) < 400 > 21 Gly Phe Thr Phe Ser Ser Ser 1 5 < 210 > 22 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Chothia ( 5 ) ( DNA ) < 400 > 22 ggattcacct ttagcagttc t 21 < 210 > 23 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 1 ) < 400 > 23 Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 1 5 10 < 210 > 24 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 1 ) ( DNA 1 ) < 400 > 24 ggattcacct ttagcagtta tgccatgagc 30 < 210 > 25 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 2 ) < 400 > 25 Gly Ser Thr Phe Ser Ser Tyr Ala Met Ser 1 5 10 < 210 > 26 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 2 ) ( DNA ) < 400 > 26 ggatccacct ttagcagtta tgccatgagc 30 < 210 > 27 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 3 ) < 400 > 27 Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser 1 5 10 < 210 > 28 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 3 ) ( DNA ) < 400 > 28 ggattcacct ttagcagtta taccatgagc 30 < 210 > 29 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 4 ) < 400 > 29 Gly Phe Thr Phe Ser Ser Phe Ala Met Ser 1 5 10 < 210 > 30 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 4 ) ( DNA ) < 400 > 30 ggattcacct ttagcagttt tgccatgagc 30 < 210 > 31 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 5 ) < 400 > 31 Gly Phe Thr Phe Ser Ser His Ala Met Ser 1 5 10 < 210 > 32 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 5 ) ( DNA ) < 400 > 32 ggattcacct ttagcagtca tgctatgagc 30 < 210 > 33 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 6 ) < 400 > 33 Gly Phe Thr Phe Ser Ser Ser Ala Met Ser 1 5 10 < 210 > 34 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 6 ) ( DNA ) < 400 > 34 ggattcacct ttagcagttc tgccatgagc 30 < 210 > 35 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 1 ) < 400 > 35 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 36 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 1 ) ( DNA 1 ) < 400 > 36 gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaag 48 < 210 > 37 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 2 ) < 400 > 37 Ala Ile Gly Val Ser Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 38 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 2 ) ( DNA ) < 400 > 38 gctattggtg ttagtactgg tagcacatac tacgcagact ccgtgaag 48 < 210 > 39 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 3 ) < 400 > 39 Ala Ile Ser Gly Ser Ala Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 40 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 3 ) ( DNA ) < 400 > 40 gctattagtg ggagtgctgg ttatacatac tacgcagact ccgtgaag 48 < 210 > 41 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 4 ) < 400 > 41 Ala Ile Ser Gly Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 42 < 211 > 45 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 4 ) ( DNA ) < 400 > 42 gctattagtg gtggtggtag gacatactac gcagactccg tgaag 45 < 210 > 43 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 5 ) < 400 > 43 Ala Ile Ile Ser Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 44 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 5 ) ( DNA ) < 400 > 44 gcgattatta gtagtggtgg tctcacatac tacgcagact ccgtgaag 48 < 210 > 45 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 6 ) < 400 > 45 Ala Ile Ile Gly Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 46 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 6 ) ( DNA ) < 400 > 46 gctattattg ggagtggtag tcgtacatac tacgcagact ccgtgaag 48 < 210 > 47 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 7 ) < 400 > 47 Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 48 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 7 ) ( DNA ) < 400 > 48 gctattattg gtagtggtgc tagcacatac tacgcagact ccgtgaag 48 < 210 > 49 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 8 ) < 400 > 49 Ala Ile Trp Gly Gly Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 50 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 8 ) ( DNA ) < 400 > 50 gctatttggg gtggtggtcg tagcacatac tacgcagact ccgtgaag 48 < 210 > 51 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 9 ) < 400 > 51 Ala Ile Ile Ser Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 52 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 9 ) ( DNA ) < 400 > 52 gctattatta gtagtggggc tagcacatac tacgcagact ccgtgaag 48 < 210 > 53 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 10 ) < 400 > 53 Ala Ile Leu Ala Ser Gly Ala Ile Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 54 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 10 ) ( DNA ) < 400 > 54 gctattttgg ctagtggtgc gatcacatac tacgcagact ccgtgaag 48 < 210 > 55 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 11 ) < 400 > 55 Gly Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 56 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 11 ) ( DNA ) < 400 > 56 ggtattattg gtagtggtgg tatcacatac tacgcagact ccgtgaag 48 < 210 > 57 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 12 ) < 400 > 57 Ala Ile Leu Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 58 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 12 ) ( DNA ) < 400 > 58 gctattcttg gtagtggtgg tagcacatac tacgcagact ccgtgaag 48 < 210 > 59 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 13 ) < 400 > 59 Ala Ile Ile Gly Ser Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 60 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 13 ) ( DNA ) < 400 > 60 gctattattg gtagtggtag taacacatac tacgcagact ccgtgaag 48 < 210 > 61 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 14 ) < 400 > 61 Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 62 < 211 > 45 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 14 ) ( DNA ) < 400 > 62 gctatttggg ctagtgggga gcaatactac gcagactccg tgaag 45 < 210 > 63 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 15 ) < 400 > 63 Ala Ile Ile Gly Ser Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 64 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 15 ) ( DNA ) < 400 > 64 gctattattg gtagtggtag tatcacatac tacgcagact ccgtgaag 48 < 210 > 65 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 16 ) < 400 > 65 Ala Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 66 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 16 ) ( DNA ) < 400 > 66 gctattattg gtagtggtgg tatcacatac tacgcagact ccgtgaag 48 < 210 > 67 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 17 ) < 400 > 67 Ala Ile Ser Thr Asn Gly Asn Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 < 210 > 68 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 17 ) ( DNA ) < 400 > 68 gctattagta ctaatggtaa ttatacatac tacgcagact ccgtgaag 48 < 210 > 69 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 1 ) < 400 > 69 Ser Gly Ser Gly Gly Ser Thr 1 5 < 210 > 70 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 1 ) ( DNA 1 ) < 400 > 70 agtggtagtg gtggtagcac a 21 < 210 > 71 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 2 ) < 400 > 71 Gly Val Ser Thr Gly Ser Thr 1 5 < 210 > 72 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 2 ) ( DNA ) < 400 > 72 ggtgttagta ctggtagcac a 21 < 210 > 73 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 3 ) < 400 > 73 Ser Gly Ser Ala Gly Tyr Thr 1 5 < 210 > 74 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 3 ) ( DNA ) < 400 > 74 agtgggagtg ctggttatac a 21 < 210 > 75 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 4 ) < 400 > 75 Ser Gly Gly Gly Arg Thr 1 5 < 210 > 76 < 211 > 18 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 4 ) ( DNA ) < 400 > 76 agtggtggtg gtaggaca 18 < 210 > 77 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 5 ) < 400 > 77 Ile Ser Ser Gly Gly Leu Thr 1 5 < 210 > 78 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 5 ) ( DNA ) < 400 > 78 attagtagtg gtggtctcac a 21 < 210 > 79 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 6 ) < 400 > 79 Ile Gly Ser Gly Ser Arg Thr 1 5 < 210 > 80 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 6 ) ( DNA ) < 400 > 80 attgggagtg gtagtcgtac a 21 < 210 > 81 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 7 ) < 400 > 81 Ile Gly Ser Gly Ala Ser Thr 1 5 < 210 > 82 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 7 ) ( DNA ) < 400 > 82 attggtagtg gtgctagcac a 21 < 210 > 83 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 8 ) < 400 > 83 Trp Gly Gly Gly Arg Ser Thr 1 5 < 210 > 84 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 8 ) ( DNA ) < 400 > 84 attggtagtg gtgctagcac a 21 < 210 > 85 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 9 ) < 400 > 85 Ile Ser Ser Gly Ala Ser Thr 1 5 < 210 > 86 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 9 ) ( DNA ) < 400 > 86 attagtagtg gggctagcac a 21 < 210 > 87 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 10 ) < 400 > 87 Leu Ala Ser Gly Ala Ile Thr 1 5 < 210 > 88 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 10 ) ( DNA ) < 400 > 88 ttggctagtg gtgcgatcac a 21 < 210 > 89 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 11 ) < 400 > 89 Ile Gly Ser Gly Gly Ile Thr 1 5 < 210 > 90 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 11 ) ( DNA ) < 400 > 90 attggtagtg gtggtatcac a 21 < 210 > 91 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 12 ) < 400 > 91 Leu Gly Ser Gly Gly Ser Thr 1 5 < 210 > 92 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 12 ) ( DNA ) < 400 > 92 cttggtagtg gtggtagcac a 21 < 210 > 93 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 13 ) < 400 > 93 Ile Gly Ser Gly Ser Asn Thr 1 5 < 210 > 94 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 13 ) ( DNA ) < 400 > 94 attggtagtg gtagtaacac a 21 < 210 > 95 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 14 ) < 400 > 95 Trp Ala Ser Gly Glu Gln 1 5 < 210 > 96 < 211 > 18 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 14 ) ( DNA ) < 400 > 96 tgggctagtg gggagcaa 18 < 210 > 97 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 15 ) < 400 > 97 Ile Gly Ser Gly Ser Ile Thr 1 5 < 210 > 98 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 15 ) ( DNA ) < 400 > 98 attggtagtg gtagtatcac a 21 < 210 > 99 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 16 ) < 400 > 99 Ser Thr Asn Gly Asn Tyr Thr 1 5 < 210 > 100 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 16 ) ( DNA ) < 400 > 100 agtactaatg gtaattatac a 21 < 210 > 101 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 1 ) < 400 > 101 Ala Ile Ser Gly Ser Gly Gly Ser Thr 1 5 < 210 > 102 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 1 ) ( DNA 1 ) < 400 > 102 gctattagtg gtagtggtgg tagcaca 27 < 210 > 103 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 2 ) < 400 > 103 Ala Ile Gly Val Ser Thr Gly Ser Thr 1 5 < 210 > 104 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 2 ) ( DNA ) < 400 > 104 gctattggtg ttagtactgg tagcaca 27 < 210 > 105 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 3 ) < 400 > 105 Ala Ile Ser Gly Ser Ala Gly Tyr Thr 1 5 < 210 > 106 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 3 ) ( DNA ) < 400 > 106 gctattagtg ggagtgctgg ttataca 27 < 210 > 107 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 4 ) < 400 > 107 Ala Ile Ser Gly Gly Gly Arg Thr 1 5 < 210 > 108 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 4 ) ( DNA ) < 400 > 108 gctattagtg gtggtggtag gaca 24 < 210 > 109 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 5 ) < 400 > 109 Ala Ile Ile Ser Ser Gly Gly Leu Thr 1 5 < 210 > 110 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 5 ) ( DNA ) < 400 > 110 gcgattatta gtagtggtgg tctcaca 27 < 210 > 111 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 6 ) < 400 > 111 Ala Ile Ile Gly Ser Gly Ser Arg Thr 1 5 < 210 > 112 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 6 ) ( DNA ) < 400 > 112 gctattattg ggagtggtag tcgtaca 27 < 210 > 113 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 7 ) < 400 > 113 Ala Ile Ile Gly Ser Gly Ala Ser Thr 1 5 < 210 > 114 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 7 ) ( DNA ) < 400 > 114 gctattattg gtagtggtgc tagcaca 27 < 210 > 115 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 8 ) < 400 > 115 Ala Ile Trp Gly Gly Gly Arg Ser Thr 1 5 < 210 > 116 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 8 ) ( DNA ) < 400 > 116 gctatttggg gtggtggtcg tagcaca 27 < 210 > 117 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 9 ) < 400 > 117 Ala Ile Ile Ser Ser Gly Ala Ser Thr 1 5 < 210 > 118 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 9 ) ( DNA ) < 400 > 118 gctattatta gtagtggggc tagcaca 27 < 210 > 119 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 10 ) < 400 > 119 Ala Ile Leu Ala Ser Gly Ala Ile Thr 1 5 < 210 > 120 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 10 ) ( DNA ) < 400 > 120 gctattttgg ctagtggtgc gatcaca 27 < 210 > 121 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 11 ) < 400 > 121 Gly Ile Ile Gly Ser Gly Gly Ile Thr 1 5 < 210 > 122 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 11 ) ( DNA ) < 400 > 122 ggtattattg gtagtggtgg tatcaca 27 < 210 > 123 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 12 ) < 400 > 123 Ala Ile Leu Gly Ser Gly Gly Ser Thr 1 5 < 210 > 124 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 12 ) ( DNA ) < 400 > 124 gctattcttg gtagtggtgg tagcaca 27 < 210 > 125 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 13 ) < 400 > 125 Ala Ile Ile Gly Ser Gly Ser Asn Thr 1 5 < 210 > 126 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 13 ) ( DNA ) < 400 > 126 gctattattg gtagtggtag taacaca 27 < 210 > 127 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 14 ) < 400 > 127 Ala Ile Trp Ala Ser Gly Glu Gln 1 5 < 210 > 128 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 14 ) ( DNA ) < 400 > 128 gctatttggg ctagtgggga gcaa 24 < 210 > 129 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 15 ) < 400 > 129 Ala Ile Ile Gly Ser Gly Ser Ile Thr 1 5 < 210 > 130 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 15 ) ( DNA ) < 400 > 130 gctattattg gtagtggtag tatcaca 27 < 210 > 131 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 16 ) < 400 > 131 Ala Ile Ile Gly Ser Gly Gly Ile Thr 1 5 < 210 > 132 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 16 ) ( DNA ) < 400 > 132 gctattattg gtagtggtgg tatcaca 27 < 210 > 133 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 17 ) < 400 > 133 Ala Ile Ser Thr Asn Gly Asn Tyr Thr 1 5 < 210 > 134 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 17 ) ( DNA ) < 400 > 134 gctattagta ctaatggtaa ttataca 27 < 210 > 135 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 1 ) < 400 > 135 Tyr Cys Ala Lys Gly Trp Phe Gly 1 5 < 210 > 136 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 1 ) ( DNA 1 ) < 400 > 136 tactgtgcga aagggtggtt tggt 24 < 210 > 137 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 2 ) < 400 > 137 Tyr Cys Ala Lys Gly Trp Leu Gly 1 5 < 210 > 138 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 2 ) ( DNA 1 ) < 400 > 138 tactgtgcga aaggttggct gggt 24 < 210 > 139 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 3 ) < 400 > 139 Tyr Cys Ala Lys Gly Trp Phe Thr 1 5 < 210 > 140 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 3 ) ( DNA ) < 400 > 140 tactgtgcga aaggttggtt tacg 24 < 210 > 141 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 4 ) < 400 > 141 Tyr Cys Ala Lys Ala Trp Met Gly 1 5 < 210 > 142 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 4 ) ( DNA ) < 400 > 142 tactgtgcga aagcttggat gggg 24 < 210 > 143 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 1 ( 1 ) < 400 > 143 Arg Ala Ser Gln Ser Val Thr Ser Ser Tyr Leu 1 5 10 < 210 > 144 < 211 > 33 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 1 ( 1 ) ( DNA ) < 400 > 144 agggccagtc agagtgttac cagtagctac tta 33 < 210 > 145 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 1 ( 2 ) < 400 > 145 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu 1 5 10 < 210 > 146 < 211 > 33 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 1 ( 2 ) ( DNA ) < 400 > 146 agggccagtc agagtgttag cagcagctac tta 33 < 210 > 147 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 1 ( 3 ) < 400 > 147 Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu 1 5 10 < 210 > 148 < 211 > 33 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 1 ( 3 ) ( DNA ) < 400 > 148 agggccagtc agagtgttag ccgcagctac tta 33 < 210 > 149 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 1 ( 4 ) < 400 > 149 Arg Ala Ser Gln Ser Val Ser Ser Asn Tyr Leu 1 5 10 < 210 > 150 < 211 > 33 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 1 ( 4 ) ( DNA 1 ) < 400 > 150 agggccagtc agagtgttag cagcaattac tta 33 < 210 > 151 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 1 ) < 400 > 151 Asn Val Gly Ser Arg Arg Ala 1 5 < 210 > 152 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 1 ) ( DNA ) < 400 > 152 aatgtgggct cccgtagggc c 21 < 210 > 153 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 2 ) < 400 > 153 Tyr Gly Ala Ser Ser Arg Ala 1 5 < 210 > 154 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 2 ) ( DNA ) < 400 > 154 tatggagcat ccagcagggc c 21 < 210 > 155 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 3 ) < 400 > 155 Ile Gly Ala Ser Thr Arg Ala 1 5 < 210 > 156 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 3 ) ( DNA ) < 400 > 156 attggggcct ccaccagggc c 21 < 210 > 157 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 4 ) < 400 > 157 Tyr Gly Ala Tyr Ile Arg Ala 1 5 < 210 > 158 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 4 ) ( DNA ) < 400 > 158 tatggcgcct acatcagggc c 21 < 210 > 159 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 5 ) < 400 > 159 Gln Gly Ala Ser Ser Arg Ala 1 5 < 210 > 160 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 5 ) ( DNA ) < 400 > 160 cagggcgcct ccagcagggc c 21 < 210 > 161 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 6 ) < 400 > 161 Tyr Gly Ala Ser Ile Arg Ala 1 5 < 210 > 162 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 2 ( 6 ) ( DNA ) < 400 > 162 tatggtgcct ccattagggc c 21 < 210 > 163 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 1 ) < 400 > 163 Cys Gln Gln Gly Ile Met Leu Pro Pro 1 5 < 210 > 164 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 1 ) ( DNA ) < 400 > 164 tgtcagcagg gtattatgct tcccccg 27 < 210 > 165 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 2 ) < 400 > 165 Cys Gln Gln Gly Gln Leu Ile Pro Pro 1 5 < 210 > 166 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 2 ) ( DNA ) < 400 > 166 tgtcagcagg gtcagcttat tccccct 27 < 210 > 167 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 3 ) < 400 > 167 Cys Gln Gln Gly Gln Val Ile Pro Pro 1 5 < 210 > 168 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 3 ) ( DNA ) < 400 > 168 tgtcagcagg gtcaggttat tccccct 27 < 210 > 169 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 4 ) < 400 > 169 Cys Gln Gln Gly Gln Gln Ile Pro Pro 1 5 < 210 > 170 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 4 ) ( DNA ) < 400 > 170 tgtcagcagg gtcagcagat tccccct 27 < 210 > 171 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 5 ) < 400 > 171 Cys Gln Gln Gly Asn Gln Ile Pro Pro 1 5 < 210 > 172 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 5 ) ( DNA ) < 400 > 172 tgtcagcagg gtaatcagat tccccct 27 < 210 > 173 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 6 ) < 400 > 173 Cys Gln Gln Gly Leu Asn Ile Pro Ser 1 5 < 210 > 174 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 6 ) ( DNA ) < 400 > 174 tgtcagcagg gtctgaatat tccctcg 27 < 210 > 175 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 7 ) < 400 > 175 Cys Gln Gln Gly His Ile Ile Pro Pro 1 5 < 210 > 176 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 7 ) ( DNA ) < 400 > 176 tgtcagcagg gtcatattat tcccccg 27 < 210 > 177 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 8 ) < 400 > 177 Cys Gln Gln Ala Ile Met Leu Pro Pro 1 5 < 210 > 178 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 3 ( 8 ) ( DNA ) < 400 > 178 tgtcagcagg ctattatgct tcctccg 27 < 210 > 179 < 211 > 15 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 1 ) ( DNA 2 ) < 400 > 179 agttatgcta tgagc 15 < 210 > 180 < 211 > 15 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 1 ) ( DNA 3 ) < 400 > 180 agttatgcga tgagc 15 < 210 > 181 < 211 > 15 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 Kabat ( 1 ) ( DNA 4 ) < 400 > 181 agttatgcaa tgagc 15 < 210 > 182 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 1 ) ( DNA 2 ) < 400 > 182 ggattcacct ttagcagtta tgctatgagc 30 < 210 > 183 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 1 ) ( DNA 3 ) < 400 > 183 ggattcacct ttagcagtta tgcgatgagc 30 < 210 > 184 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 1 AbM ( 1 ) ( DNA 4 ) < 400 > 184 ggattcacct ttagcagtta tgcaatgagc 30 < 210 > 185 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Kabat ( 1 ) ( DNA 2 ) < 400 > 185 gctattagcg gtagtggtgg tagcacatac tacgcagact ccgtgaag 48 < 210 > 186 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 Chothia ( 1 ) ( DNA 2 ) < 400 > 186 agcggtagtg gtggtagcac a 21 < 210 > 187 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 2 AbM ( 1 ) ( DNA 2 ) < 400 > 187 gctattagcg gtagtggtgg tagcaca 27 < 210 > 188 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 1 ) ( DNA 2 ) < 400 > 188 tactgtgcga aaggttggtt tggg 24 < 210 > 189 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 2 ) ( DNA 2 ) < 400 > 189 tactgtgcga aagggtggct gggt 24 < 210 > 190 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > HCDR 3 ( 2 ) ( DNA 3 ) < 400 > 190 tactgtgcga aaggttggtt gggt 24 < 210 > 191 < 211 > 33 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 1 ( 4 ) ( DNA 2 ) < 400 > 191 agggccagtc agagtgttag cagcaactac tta 33 < 210 > 192 < 211 > 33 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LCDR 1 ( 4 ) ( DNA 3 ) < 400 > 192 agggccagtc agagtgttag cagtaactac tta 33 < 210 > 193 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 3 F 2 ; VL < 400 > 193 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Tyr Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 194 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 3 F 2 ; VL < 400 > 194 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt atccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 195 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 3 F 2 ( YS ) ; VL < 400 > 195 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 196 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 3 F 2 ( YS ) ; VL < 400 > 196 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 197 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 3 F 2 ; VH < 400 > 197 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 198 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 3 F 2 ; VH < 400 > 198 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 199 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 3 D 9 , VL < 400 > 199 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Leu Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 200 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 3 D 9 , VL < 400 > 200 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcagc ttattccccc tacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 201 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 3 D 9 , VH < 400 > 201 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Gly Val Ser Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 202 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 3 D 9 , VH < 400 > 202 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccagact 120 ccagggaagg ggctggagtg ggtctcagct attggtgtta gtactggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg 300 ctgggtcctt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 203 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 3 D 9 ( TA ) ; VH < 400 > 203 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Gly Val Ser Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 204 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 3 D 9 ( TA ) ; VH < 400 > 204 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attggtgtta gtactggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg 300 ctgggtcctt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 205 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 4 G 8 ; VL < 400 > 205 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 206 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 4 G 8 ; VL < 400 > 206 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc cgcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcatt ggggcctcca ccagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggacg gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 207 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 4 G 8 ; VH < 400 > 207 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 208 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 4 G 8 ; VH < 400 > 208 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 209 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 4 B 3 ; VL < 400 > 209 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Tyr Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 210 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 4 B 3 ; VL < 400 > 210 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcaattact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggcgcctaca tcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 211 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 4 B 3 ; VH < 400 > 211 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 212 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 4 B 3 ; VH < 400 > 212 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 213 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 4 D 6 ; VL < 400 > 213 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Gln Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 214 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 4 D 6 ; VL < 400 > 214 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcaactact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatccag ggcgcctcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 215 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 4 D 6 ; VH < 400 > 215 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 216 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 4 D 6 ; VH < 400 > 216 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 217 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 2 C 6 ; VL < 400 > 217 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Gln Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 218 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 2 C 6 ; VL < 400 > 218 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag caggctggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcagc agattccccc tacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 219 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 2 C 6 ; VH < 400 > 219 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Ala Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 220 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 2 C 6 ; VH < 400 > 220 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatc cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggga gtgctggtta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg 300 tttgggaatt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 221 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 5 H 5 ; VL < 400 > 221 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Gln Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 222 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 5 H 5 ; VL < 400 > 222 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtaatc agattccccc tacgttcggt 300 caggggacca aagtggaaat caaa 324 < 210 > 223 < 211 > 116 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 5 H 5 ; VH < 400 > 223 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met Ser Trp Val Arg Arg Ser Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Gly Trp Phe Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 224 < 211 > 348 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 5 H 5 ; VH < 400 > 224 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatacca tgagctgggt ccgccggtct 120 ccagggaagg ggctggagtg ggtctcagct attagtggtg gtggtaggac atactacgca 180 gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg 240 cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa aggttggttt 300 acgccttttg actactgggg ccaaggaacc ctggtcaccg tctcgagt 348 < 210 > 225 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 2 C 4 ; VL < 400 > 225 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Gln Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 226 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 2 C 4 ; VL < 400 > 226 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agtaactact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcctcca ttagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtaatc agattccccc tacgttcggt 300 caggggacca aagtggaaat caaa 324 < 210 > 227 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 2 C 4 ; VH < 400 > 227 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 228 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 2 C 4 ; VH < 400 > 228 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg 300 tttacgcctt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 229 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 2 D 9 ; VL < 400 > 229 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Gln Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 230 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 2 D 9 ; VL < 400 > 230 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtaatc agattccccc tacgttcggt 300 caggggacca aagtggaaat caaa 324 < 210 > 231 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 2 D 9 ; VH < 400 > 231 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 232 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 2 D 9 ; VH < 400 > 232 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg 300 tttacgcctt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 233 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 4 B 8 ; VL < 400 > 233 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 234 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 4 B 8 ; VL < 400 > 234 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 235 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 4 B 8 ; VH < 400 > 235 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 236 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 4 B 8 ; VH < 400 > 236 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 237 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 7 A 1 ; VL < 400 > 237 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Gln Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 238 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 7 A 1 ; VL < 400 > 238 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcagc agattccccc tacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 239 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 7 A 1 ; VH < 400 > 239 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 240 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 7 A 1 ; VH < 400 > 240 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg 300 tttgggaatt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 241 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 13 C 2 ; VL < 400 > 241 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Leu Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 242 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 13 C 2 ; VL < 400 > 242 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcagc ttattccccc tacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 243 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 13 C 2 ; VH < 400 > 243 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 244 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 13 C 2 ; VH < 400 > 244 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg 300 ctgggtcctt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 245 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 13 E 8 ; VL < 400 > 245 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Leu Asn Ile Pro 85 90 95 Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 246 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 13 E 8 ; VL < 400 > 246 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtctga atattccctc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 247 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 13 E 8 ; VH < 400 > 247 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 248 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 13 E 8 ; VH < 400 > 248 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg 300 ttgggtccgt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 249 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 14 C 10 ; VL < 400 > 249 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly His Ile Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 250 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 14 C 10 ; VL < 400 > 250 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcata ttattccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 251 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 14 C 10 ; VH < 400 > 251 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Trp Met Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 252 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 14 C 10 ; VH < 400 > 252 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagcttgg 300 atggggcctt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 253 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 17 A 11 ; VL < 400 > 253 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Leu Asn Ile Pro 85 90 95 Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 254 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 17 A 11 ; VL < 400 > 254 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtctga atattccctc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 255 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 17 A 11 ; VH < 400 > 255 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 256 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 17 A 11 ; VH < 400 > 256 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg 300 ttgggtccgt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 257 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 19 G 1 ; VL < 400 > 257 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 258 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 19 G 1 ; VL < 400 > 258 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 259 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 19 G 1 ; VH < 400 > 259 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ile Ser Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 260 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 19 G 1 ; VH < 400 > 260 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcga tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagcg attattagta gtggtggtct cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c 351 < 210 > 261 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 20 G 8 ; VL < 400 > 261 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 262 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 20 G 8 ; VL < 400 > 262 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 263 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 20 G 8 ; VH < 400 > 263 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ile Gly Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 264 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 20 G 8 ; VH < 400 > 264 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcaa tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attattggga gtggtagtcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c 351 < 210 > 265 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 4 B 9 ; VL < 400 > 265 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 266 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 4 B 9 ; VL < 400 > 266 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 267 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 4 B 9 ; VH < 400 > 267 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 268 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 4 B 9 ; VH < 400 > 268 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attattggta gtggtgctag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c 351 < 210 > 269 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 5 B 8 ; VL < 400 > 269 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 270 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 5 B 8 ; VL < 400 > 270 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 271 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 5 B 8 ; VH < 400 > 271 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Trp Gly Gly Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 272 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 5 B 8 ; VH < 400 > 272 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct atttggggtg gtggtcgtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c 351 < 210 > 273 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 5 F 1 ; VL < 400 > 273 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 274 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 5 F 1 ; VL < 400 > 274 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 275 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 5 F 1 ; VH < 400 > 275 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ile Ser Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 276 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 5 F 1 ; VH < 400 > 276 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attattagta gtggggctag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c 351 < 210 > 277 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 14 B 3 ; VL < 400 > 277 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 278 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 14 B 3 ; VL < 400 > 278 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 279 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 14 B 3 ; VH < 400 > 279 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Leu Ala Ser Gly Ala Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 280 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 14 B 3 ; VH < 400 > 280 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attttggcta gtggtgcgat cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c 351 < 210 > 281 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 16 F 1 ; VL < 400 > 281 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 282 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 16 F 1 ; VL < 400 > 282 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 283 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 16 F 1 ; VH < 400 > 283 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 284 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 16 F 1 ; VH < 400 > 284 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcaggt attattggta gtggtggtat cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c 351 < 210 > 285 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 16 F 8 ; VL < 400 > 285 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 286 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 16 F 8 ; VL < 400 > 286 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 287 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 16 F 8 ; VH < 400 > 287 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Leu Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 288 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 16 F 8 ; VH < 400 > 288 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attcttggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c 351 < 210 > 289 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > O 3 C 9 ; VL < 400 > 289 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 290 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > O 3 C 9 ; VL < 400 > 290 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 291 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > O 3 C 9 ; VH < 400 > 291 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ile Gly Ser Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 292 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > O 3 C 9 ; VH < 400 > 292 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttttgcca tgagctgggt ccgtcagtct 120 ccagggaagg ggctggagtg ggtctcagct attattggta gtggtagtaa cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c 351 < 210 > 293 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > O 2 D 7 ; VL < 400 > 293 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Thr Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 294 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > O 2 D 7 ; VL < 400 > 294 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcacccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag caggctatta tgcttcctcc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 295 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > O 2 D 7 ; VH < 400 > 295 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 296 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > O 2 D 7 ; VH < 400 > 296 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c 351 < 210 > 297 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 28 H 1 ; VL < 400 > 297 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 298 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 28 H 1 ; VL < 400 > 298 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc cgcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcatt ggggcctcca ccagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 299 < 211 > 116 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 28 H 1 ; VH < 400 > 299 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 < 210 > 300 < 211 > 348 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 28 H 1 ; VH < 400 > 300 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agtcatgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct atttgggcta gtggggagca atactacgca 180 gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg 240 cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa agggtggctg 300 ggtaattttg actactgggg ccaaggaacc ctggtcaccg tctcgagt 348 < 210 > 301 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 22 A 3 ; VL < 400 > 301 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 302 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 22 A 3 ; VL < 400 > 302 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 303 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 22 A 3 ; VH < 400 > 303 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ile Gly Ser Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 304 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 22 A 3 ; VH < 400 > 304 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attattggta gtggtagtat cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 305 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 29 B 11 ; VL < 400 > 305 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 306 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 29 B 11 ; VL < 400 > 306 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 307 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 29 B 11 ; VH < 400 > 307 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 308 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 29 B 11 ; VH < 400 > 308 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attattggta gtggtggtat cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 309 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 23 C 10 ; VL < 400 > 309 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 310 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 23 C 10 ; VL < 400 > 310 gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcttgca gggccagtca gagtgttagc cgcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcatt ggggcctcca ccagggccac tggcatccca 180 gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc 300 caggggacca aagtggaaat caaa 324 < 210 > 311 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > 23 C 10 ; VH < 400 > 311 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Thr Asn Gly Asn Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 312 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > 23 C 10 ; VH < 400 > 312 gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctccggatt cacctttagc agttctgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtacta atggtaatta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg 300 ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t 351 < 210 > 313 < 211 > 330 < 212 > PRT < 213 > Homo sapiens < 400 > 313 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 < 210 > 314 < 211 > 990 < 212 > DNA < 213 > Homo sapiens < 400 > 314 gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180 ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc 300 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 540 agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 600 gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 660 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 720 ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 840 ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 900 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 960 cagaagagcc tctccctgtc tccgggtaaa 990 < 210 > 315 < 211 > 107 < 212 > PRT < 213 > Homo sapiens < 400 > 315 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 20 25 30 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 35 40 45 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 65 70 75 80 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 85 90 95 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 < 210 > 316 < 211 > 321 < 212 > DNA < 213 > Homo sapiens < 400 > 316 cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct 60 ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag 120 tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac 180 agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag 240 aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag 300 agcttcaaca ggggagagtg t 321 < 210 > 317 < 211 > 748 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Human FAP ectodomain + poly - lys - tag + his 6 - tag < 400 > 317 Arg Pro Ser Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala Leu 1 5 10 15 Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe 20 25 30 Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp Asn 35 40 45 Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu 50 55 60 Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser 65 70 75 80 Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 85 90 95 Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly 100 105 110 Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 115 120 125 Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 130 135 140 Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn 145 150 155 160 Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 165 170 175 Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly 180 185 190 Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile 195 200 205 Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile 210 215 220 Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe Ile 225 230 235 240 Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val 245 250 255 Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 260 265 270 Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 275 280 285 Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp 290 295 300 Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 305 310 315 320 Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile 325 330 335 Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 340 345 350 Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 355 360 365 Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 370 375 380 Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 385 390 395 400 Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys His 405 410 415 Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr 420 425 430 Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser 435 440 445 Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu 450 455 460 Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu 465 470 475 480 Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys Met 485 490 495 Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 500 505 510 Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala 515 520 525 Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala 530 535 540 Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 545 550 555 560 Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 565 570 575 Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 580 585 590 Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 595 600 605 Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 610 615 620 Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly 625 630 635 640 Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 645 650 655 Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 660 665 670 Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 675 680 685 Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 690 695 700 Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr Thr 705 710 715 720 His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly Lys 725 730 735 Lys Lys Lys Lys Lys Gly His His His His His His 740 745 < 210 > 318 < 211 > 2244 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Human FAP ectodomain + poly - lys - tag + his 6 - tag < 400 > 318 cgcccttcaa gagttcataa ctctgaagaa aatacaatga gagcactcac actgaaggat 60 attttaaatg gaacattttc ttataaaaca ttttttccaa actggatttc aggacaagaa 120 tatcttcatc aatctgcaga taacaatata gtactttata atattgaaac aggacaatca 180 tataccattt tgagtaatag aaccatgaaa agtgtgaatg cttcaaatta cggcttatca 240 cctgatcggc aatttgtata tctagaaagt gattattcaa agctttggag atactcttac 300 acagcaacat attacatcta tgaccttagc aatggagaat ttgtaagagg aaatgagctt 360 cctcgtccaa ttcagtattt atgctggtcg cctgttggga gtaaattagc atatgtctat 420 caaaacaata tctatttgaa acaaagacca ggagatccac cttttcaaat aacatttaat 480 ggaagagaaa ataaaatatt taatggaatc ccagactggg tttatgaaga ggaaatgctt 540 gctacaaaat atgctctctg gtggtctcct aatggaaaat ttttggcata tgcggaattt 600 aatgatacgg atataccagt tattgcctat tcctattatg gcgatgaaca atatcctaga 660 acaataaata ttccataccc aaaggctgga gctaagaatc ccgttgttcg gatatttatt 720 atcgatacca cttaccctgc gtatgtaggt ccccaggaag tgcctgttcc agcaatgata 780 gcctcaagtg attattattt cagttggctc acgtgggtta ctgatgaacg agtatgtttg 840 cagtggctaa aaagagtcca gaatgtttcg gtcctgtcta tatgtgactt cagggaagac 900 tggcagacat gggattgtcc aaagacccag gagcatatag aagaaagcag aactggatgg 960 gctggtggat tctttgtttc aacaccagtt ttcagctatg atgccatttc gtactacaaa 1020 atatttagtg acaaggatgg ctacaaacat attcactata tcaaagacac tgtggaaaat 1080 gctattcaaa ttacaagtgg caagtgggag gccataaata tattcagagt aacacaggat 1140 tcactgtttt attctagcaa tgaatttgaa gaataccctg gaagaagaaa catctacaga 1200 attagcattg gaagctatcc tccaagcaag aagtgtgtta cttgccatct aaggaaagaa 1260 aggtgccaat attacacagc aagtttcagc gactacgcca agtactatgc acttgtctgc 1320 tacggcccag gcatccccat ttccaccctt catgatggac gcactgatca agaaattaaa 1380 atcctggaag aaaacaagga attggaaaat gctttgaaaa atatccagct gcctaaagag 1440 gaaattaaga aacttgaagt agatgaaatt actttatggt acaagatgat tcttcctcct 1500 caatttgaca gatcaaagaa gtatcccttg ctaattcaag tgtatggtgg tccctgcagt 1560 cagagtgtaa ggtctgtatt tgctgttaat tggatatctt atcttgcaag taaggaaggg 1620 atggtcattg ccttggtgga tggtcgagga acagctttcc aaggtgacaa actcctctat 1680 gcagtgtatc gaaagctggg tgtttatgaa gttgaagacc agattacagc tgtcagaaaa 1740 ttcatagaaa tgggtttcat tgatgaaaaa agaatagcca tatggggctg gtcctatgga 1800 ggatacgttt catcactggc ccttgcatct ggaactggtc ttttcaaatg tggtatagca 1860 gtggctccag tctccagctg ggaatattac gcgtctgtct acacagagag attcatgggt 1920 ctcccaacaa aggatgataa tcttgagcac tataagaatt caactgtgat ggcaagagca 1980 gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac 2040 tttcaaaact cagcacagat tgctaaagct ctggttaatg cacaagtgga tttccaggca 2100 atgtggtact ctgaccagaa ccacggctta tccggcctgt ccacgaacca cttatacacc 2160 cacatgaccc acttcctaaa gcagtgtttc tctttgtcag acggcaaaaa gaaaaagaaa 2220 aagggccacc accatcacca tcac 2244 < 210 > 319 < 211 > 749 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Murine FAP ectodomain + poly - lys - tag + his 6 - tag < 400 > 319 Arg Pro Ser Arg Val Tyr Lys Pro Glu Gly Asn Thr Lys Arg Ala Leu 1 5 10 15 Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Tyr Phe 20 25 30 Pro Asn Trp Ile Ser Glu Gln Glu Tyr Leu His Gln Ser Glu Asp Asp 35 40 45 Asn Ile Val Phe Tyr Asn Ile Glu Thr Arg Glu Ser Tyr Ile Ile Leu 50 55 60 Ser Asn Ser Thr Met Lys Ser Val Asn Ala Thr Asp Tyr Gly Leu Ser 65 70 75 80 Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 85 90 95 Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Gln Asn Gly 100 105 110 Glu Phe Val Arg Gly Tyr Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 115 120 125 Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 130 135 140 Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Tyr Thr 145 150 155 160 Gly Arg Glu Asn Arg Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 165 170 175 Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asp Gly 180 185 190 Lys Phe Leu Ala Tyr Val Glu Phe Asn Asp Ser Asp Ile Pro Ile Ile 195 200 205 Ala Tyr Ser Tyr Tyr Gly Asp Gly Gln Tyr Pro Arg Thr Ile Asn Ile 210 215 220 Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Val Phe Ile 225 230 235 240 Val Asp Thr Thr Tyr Pro His His Val Gly Pro Met Glu Val Pro Val 245 250 255 Pro Glu Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 260 265 270 Val Ser Ser Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 275 280 285 Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp His Ala Trp 290 295 300 Glu Cys Pro Lys Asn Gln Glu His Val Glu Glu Ser Arg Thr Gly Trp 305 310 315 320 Ala Gly Gly Phe Phe Val Ser Thr Pro Ala Phe Ser Gln Asp Ala Thr 325 330 335 Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 340 345 350 Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 355 360 365 Trp Glu Ala Ile Tyr Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 370 375 380 Ser Ser Asn Glu Phe Glu Gly Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 385 390 395 400 Ile Ser Ile Gly Asn Ser Pro Pro Ser Lys Lys Cys Val Thr Cys His 405 410 415 Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Tyr Lys 420 425 430 Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Leu Pro Ile Ser 435 440 445 Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Gln Val Leu Glu Glu 450 455 460 Asn Lys Glu Leu Glu Asn Ser Leu Arg Asn Ile Gln Leu Pro Lys Val 465 470 475 480 Glu Ile Lys Lys Leu Lys Asp Gly Gly Leu Thr Phe Trp Tyr Lys Met 485 490 495 Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 500 505 510 Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Lys Ser Val Phe Ala 515 520 525 Val Asn Trp Ile Thr Tyr Leu Ala Ser Lys Glu Gly Ile Val Ile Ala 530 535 540 Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Phe Leu His 545 550 555 560 Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Leu Thr 565 570 575 Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Glu Arg Ile 580 585 590 Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 595 600 605 Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 610 615 620 Ser Ser Trp Glu Tyr Tyr Ala Ser Ile Tyr Ser Glu Arg Phe Met Gly 625 630 635 640 Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 645 650 655 Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 660 665 670 Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 675 680 685 Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 690 695 700 Asp Gln Asn His Gly Ile Leu Ser Gly Arg Ser Gln Asn His Leu Tyr 705 710 715 720 Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly 725 730 735 Lys Lys Lys Lys Lys Lys Gly His His His His His His 740 745 < 210 > 320 < 211 > 2247 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Murine FAP ectodomain + poly - lys - tag + his 6 - tag < 400 > 320 cgtccctcaa gagtttacaa acctgaagga aacacaaaga gagctcttac cttgaaggat 60 attttaaatg gaacattctc atataaaaca tattttccca actggatttc agaacaagaa 120 tatcttcatc aatctgagga tgataacata gtattttata atattgaaac aagagaatca 180 tatatcattt tgagtaatag caccatgaaa agtgtgaatg ctacagatta tggtttgtca 240 cctgatcggc aatttgtgta tctagaaagt gattattcaa agctctggcg atattcatac 300 acagcgacat actacatcta cgaccttcag aatggggaat ttgtaagagg atacgagctc 360 cctcgtccaa ttcagtatct atgctggtcg cctgttggga gtaaattagc atatgtatat 420 caaaacaata tttatttgaa acaaagacca ggagatccac cttttcaaat aacttatact 480 ggaagagaaa atagaatatt taatggaata ccagactggg tttatgaaga ggaaatgctt 540 gccacaaaat atgctctttg gtggtctcca gatggaaaat ttttggcata tgtagaattt 600 aatgattcag atataccaat tattgcctat tcttattatg gtgatggaca gtatcctaga 660 actataaata ttccatatcc aaaggctggg gctaagaatc cggttgttcg tgtttttatt 720 gttgacacca cctaccctca ccacgtgggc ccaatggaag tgccagttcc agaaatgata 780 gcctcaagtg actattattt cagctggctc acatgggtgt ccagtgaacg agtatgcttg 840 cagtggctaa aaagagtgca gaatgtctca gtcctgtcta tatgtgattt cagggaagac 900 tggcatgcat gggaatgtcc aaagaaccag gagcatgtag aagaaagcag aacaggatgg 960 gctggtggat tctttgtttc gacaccagct tttagccagg atgccacttc ttactacaaa 1020 atatttagcg acaaggatgg ttacaaacat attcactaca tcaaagacac tgtggaaaat 1080 gctattcaaa ttacaagtgg caagtgggag gccatatata tattccgcgt aacacaggat 1140 tcactgtttt attctagcaa tgaatttgaa ggttaccctg gaagaagaaa catctacaga 1200 attagcattg gaaactctcc tccgagcaag aagtgtgtta cttgccatct aaggaaagaa 1260 aggtgccaat attacacagc aagtttcagc tacaaagcca agtactatgc actcgtctgc 1320 tatggccctg gcctccccat ttccaccctc catgatggcc gcacagacca agaaatacaa 1380 gtattagaag aaaacaaaga actggaaaat tctctgagaa atatccagct gcctaaagtg 1440 gagattaaga agctcaaaga cgggggactg actttctggt acaagatgat tctgcctcct 1500 cagtttgaca gatcaaagaa gtaccctttg ctaattcaag tgtatggtgg tccttgtagc 1560 cagagtgtta agtctgtgtt tgctgttaat tggataactt atctcgcaag taaggagggg 1620 atagtcattg ccctggtaga tggtcggggc actgctttcc aaggtgacaa attcctgcat 1680 gccgtgtatc gaaaactggg tgtatatgaa gttgaggacc agctcacagc tgtcagaaaa 1740 ttcatagaaa tgggtttcat tgatgaagaa agaatagcca tatggggctg gtcctacgga 1800 ggttatgttt catccctggc ccttgcatct ggaactggtc ttttcaaatg tggcatagca 1860 gtggctccag tctccagctg ggaatattac gcatctatct actcagagag attcatgggc 1920 ctcccaacaa aggacgacaa tctcgaacac tataaaaatt caactgtgat ggcaagagca 1980 gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac 2040 tttcagaact cagcacagat tgctaaagct ttggttaatg cacaagtgga tttccaggcg 2100 atgtggtact ctgaccagaa ccatggtata ttatctgggc gctcccagaa tcatttatat 2160 acccacatga cgcacttcct caagcaatgc ttttctttat cagacggcaa aaagaaaaag 2220 aaaaagggcc accaccatca ccatcac 2247 < 210 > 321 < 211 > 748 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Cynomolgus FAP ectodomain + poly - lys - tag + his 6 - tag < 400 > 321 Arg Pro Pro Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala Leu 1 5 10 15 Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe 20 25 30 Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp Asn 35 40 45 Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu 50 55 60 Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser 65 70 75 80 Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 85 90 95 Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly 100 105 110 Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 115 120 125 Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 130 135 140 Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn 145 150 155 160 Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 165 170 175 Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly 180 185 190 Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile 195 200 205 Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile 210 215 220 Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Phe Val Arg Ile Phe Ile 225 230 235 240 Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val 245 250 255 Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 260 265 270 Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 275 280 285 Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp 290 295 300 Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 305 310 315 320 Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile 325 330 335 Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 340 345 350 Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 355 360 365 Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 370 375 380 Ser Ser Asn Glu Phe Glu Asp Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 385 390 395 400 Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys His 405 410 415 Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr 420 425 430 Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser 435 440 445 Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu 450 455 460 Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu 465 470 475 480 Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys Met 485 490 495 Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 500 505 510 Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala 515 520 525 Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala 530 535 540 Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 545 550 555 560 Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 565 570 575 Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 580 585 590 Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 595 600 605 Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 610 615 620 Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly 625 630 635 640 Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 645 650 655 Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 660 665 670 Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 675 680 685 Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 690 695 700 Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr Thr 705 710 715 720 His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly Lys 725 730 735 Lys Lys Lys Lys Lys Gly His His His His His His 740 745 < 210 > 322 < 211 > 2247 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Cynomolgus FAP ectodomain + poly - lys - tag + his 6 - tag ( DNA ) < 400 > 322 cgccctccaa gagttcataa ctctgaagaa aatacaatga gagcactcac actgaaggat 60 attttaaatg ggacattttc ttataaaaca ttttttccaa actggatttc aggacaagaa 120 tatcttcatc aatctgcaga taacaatata gtactttata atattgaaac aggacaatca 180 tataccattt tgagtaacag aaccatgaaa agtgtgaatg cttcaaatta tggcttatca 240 cctgatcggc aatttgtata tctagaaagt gattattcaa agctttggag atactcttac 300 acagcaacat attacatcta tgaccttagc aatggagaat ttgtaagagg aaatgagctt 360 cctcgtccaa ttcagtattt atgctggtcg cctgttggga gtaaattagc atatgtctat 420 caaaacaata tctatttgaa acaaagacca ggagatccac cttttcaaat aacatttaat 480 ggaagagaaa ataaaatatt taatggaatc ccagactggg tttatgaaga ggaaatgctt 540 gctacaaaat atgctctctg gtggtctcct aatggaaaat ttttggcata tgcggaattt 600 aatgatacag atataccagt tattgcctat tcctattatg gcgatgaaca atatcccaga 660 acaataaata ttccataccc aaaggccgga gctaagaatc cttttgttcg gatatttatt 720 atcgatacca cttaccctgc gtatgtaggt ccccaggaag tgcctgttcc agcaatgata 780 gcctcaagtg attattattt cagttggctc acgtgggtta ctgatgaacg agtatgtttg 840 cagtggctaa aaagagtcca gaatgtttcg gtcttgtcta tatgtgattt cagggaagac 900 tggcagacat gggattgtcc aaagacccag gagcatatag aagaaagcag aactggatgg 960 gctggtggat tctttgtttc aacaccagtt ttcagctatg atgccatttc atactacaaa 1020 atatttagtg acaaggatgg ctacaaacat attcactata tcaaagacac tgtggaaaat 1080 gctattcaaa ttacaagtgg caagtgggag gccataaata tattcagagt aacacaggat 1140 tcactgtttt attctagcaa tgaatttgaa gattaccctg gaagaagaaa catctacaga 1200 attagcattg gaagctatcc tccaagcaag aagtgtgtta cttgccatct aaggaaagaa 1260 aggtgccaat attacacagc aagtttcagc gactacgcca agtactatgc acttgtctgc 1320 tatggcccag gcatccccat ttccaccctt catgacggac gcactgatca agaaattaaa 1380 atcctggaag aaaacaagga attggaaaat gctttgaaaa atatccagct gcctaaagag 1440 gaaattaaga aacttgaagt agatgaaatt actttatggt acaagatgat tcttcctcct 1500 caatttgaca gatcaaagaa gtatcccttg ctaattcaag tgtatggtgg tccctgcagt 1560 cagagtgtaa ggtctgtatt tgctgttaat tggatatctt atcttgcaag taaggaaggg 1620 atggtcattg ccttggtgga tggtcgggga acagctttcc aaggtgacaa actcctgtat 1680 gcagtgtatc gaaagctggg tgtttatgaa gttgaagacc agattacagc tgtcagaaaa 1740 ttcatagaaa tgggtttcat tgatgaaaaa agaatagcca tatggggctg gtcctatgga 1800 ggatatgttt catcactggc ccttgcatct ggaactggtc ttttcaaatg tgggatagca 1860 gtggctccag tctccagctg ggaatattac gcgtctgtct acacagagag attcatgggt 1920 ctcccaacaa aggatgataa tcttgagcac tataagaatt caactgtgat ggcaagagca 1980 gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac 2040 tttcaaaact cagcacagat tgctaaagct ctggttaatg cacaagtgga tttccaggca 2100 atgtggtact ctgaccagaa ccacggctta tccggcctgt ccacgaacca cttatacacc 2160 cacatgaccc acttcctaaa gcagtgtttc tctttgtcag acggcaaaaa gaaaaagaaa 2220 aagggccacc accatcacca tcactga 2247 < 210 > 323 < 211 > 19 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Leader Sequence 1 < 400 > 323 Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 1 5 10 15 Ala His Ser < 210 > 324 < 211 > 57 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Leader Sequence 1 ( DNA 1 ) < 400 > 324 atggactgga cctggagaat cctcttcttg gtggcagcag ccacaggagc ccactcc 57 < 210 > 325 < 211 > 57 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Leader Sequence 1 ( DNA 2 ) < 400 > 325 atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc ccactcc 57 < 210 > 326 < 211 > 22 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Leader Sequence 2 < 400 > 326 Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 1 5 10 15 Phe Pro Gly Ala Arg Cys 20 < 210 > 327 < 211 > 66 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Leader Sequence 2 ( DNA ) < 400 > 327 atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt cccaggtgcc 60 aggtgt 66 < 210 > 328 < 211 > 19 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Leader Sequence 3 < 400 > 328 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser < 210 > 329 < 211 > 57 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Leader Sequence 3 ( DNA 1 ) < 400 > 329 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcc 57 < 210 > 330 < 211 > 57 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Leader Sequence 3 ( DNA 1 ) < 400 > 330 atgggctggt cctgcatcat cctgtttctg gtggctaccg ccactggagt gcattcc 57 < 210 > 331 < 211 > 57 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Leader Sequence 3 ( DNA 3 ) < 400 > 331 atgggctggt cctgcatcat cctgtttctg gtcgccacag ccaccggcgt gcactct 57 < 210 > 332 < 211 > 26 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LMB 3 < 400 > 332 caggaaacag ctatgaccat gattac 26 < 210 > 333 < 211 > 63 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LibL 1 b _ new < 220 > < 221 > misc _ feature < 222 > ( 26 ) . .( 27 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 32 ) . .( 33 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 35 ) . .( 36 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 38 ) . .( 39 ) < 223 > n is a , c , g , or t < 400 > 333 cactttggtc ccctggccga acgtmnnggg mnnmnnmnna ccctgctgac agtaatacac 60 tgc 63 < 210 > 334 < 211 > 28 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > MS 63 < 400 > 334 tttcgcacag taatatacgg ccgtgtcc 28 < 210 > 335 < 211 > 25 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > MS 64 < 400 > 335 acgttcggcc aggggaccaa agtgg 25 < 210 > 336 < 211 > 60 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Lib 2 H < 220 > < 221 > misc _ feature < 222 > ( 23 ) . .( 24 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 26 ) . .( 27 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 29 ) . .( 30 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 32 ) . .( 33 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 35 ) . .( 36 ) < 223 > n is a , c , g , or t < 400 > 336 ggccgtatat tactgtgcga aannknnknn knnknnkttt gactactggg gccaaggaac 60 < 210 > 337 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > fdseqlong < 400 > 337 gacgttagta aatgaatttt ctgtatgagg 30 < 210 > 338 < 211 > 69 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > RJH _ LIB 3 < 220 > < 221 > misc _ feature < 222 > ( 26 ) . .( 27 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 32 ) . .( 33 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 35 ) . .( 36 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 41 ) . .( 42 ) < 223 > n is a , c , g , or t < 400 > 338 gactttggtg ccctggccaa acgtmnnggg mnnmnnaccm nnctgcaagc agtaataggt 60 ggcaaaatc 69 < 210 > 339 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > RJH 31 < 400 > 339 acgtttggcc agggcaccaa agtcgag 27 < 210 > 340 < 211 > 28 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > RJH 32 < 400 > 340 tctcgcacag taatacacgg cggtgtcc 28 < 210 > 341 < 211 > 94 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > LIB 88 _ 2 < 220 > < 221 > misc _ difference < 222 > ( 29 ) . .( 55 ) < 223 > ( 33 % GAC Asp ; 26 % GGT Gly ; 10 % GAA Glu ; 9 % CGT Arg ; 7 % Lys ; 6 % GTT Val ; 5 % TCT Ser ; 4 % CTG Leu ) 1 - ( 23 % GGT Gly ; 17 % TAC Tyr ; 16 % TCT Ser ; 11 % GCT Ala ; 9 % CGT Arg ; 7 % AAC Asn ; 6 % ACT Thr ; 6 % GTT Val ; 5 % CCG Pro ) 8 < 220 > < 221 > misc _ feature < 222 > ( 30 ) . .( 33 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 35 ) . .( 36 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 38 ) . .( 39 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 41 ) . .( 42 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 44 ) . .( 45 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 47 ) . .( 48 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 50 ) . .( 51 ) < 223 > n is a , c , g , or t < 220 > < 221 > misc _ feature < 222 > ( 53 ) . .( 54 ) < 223 > n is a , c , g , or t < 400 > 341 ggacaccgcc gtgtattact gtgcgagabn nnnbnnbnnb nnbnnbnnbn nbnnbtttga 60 ctactggggc caagggacca ccgtgaccgt ctcc 94 < 210 > 342 < 211 > 60 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DPK 22 _ CDR 1 _ rand _ ba _ opt < 400 > 342 caggtttctg ctggtaccag gctaagtagc tgctgctaac actctgactg gccctgcaag 60 < 210 > 343 < 211 > 25 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DPK 22 _ CDR 1 _ fo < 400 > 343 ttagcctggt accagcagaa acctg 25 < 210 > 344 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DPK 22 _ Ck _ BsiWI _ ba < 400 > 344 ggtgcagcca ccgtacgttt gatttcc 27 < 210 > 345 < 211 > 59 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DPK 22 _ CDR 2 _ rand _ ba < 400 > 345 ctgtctggga tgccagtggc cctgctggag gcgccataga tgaggagcct gggagcctg 59 < 210 > 346 < 211 > 23 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DPK 22 _ CDR 2 _ fo < 400 > 346 agggccactg gcatcccaga cag 23 < 210 > 347 < 211 > 26 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > RJH 53 < 400 > 347 catcagggcc tgagctcgcc cgtcac 26 < 210 > 348 < 211 > 52 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DP 47 _ CDR 1 _ rand _ ba _ opt < 400 > 348 gagcctggcg gacccagctc atggcataac tgctaaaggt gaatccggag gc 52 < 210 > 349 < 211 > 22 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DP 47 _ CDR 1 _ fo < 400 > 349 atgagctggg tccgccaggc tc 22 < 210 > 350 < 211 > 26 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > MS 52 < 400 > 350 gaagaccgat gggcctttgg tgctag 26 < 210 > 351 < 211 > 73 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DP 47 _ CDR 2 _ rand _ ba < 400 > 351 ccttcacgga gtctgcgtag tatgtgctac caccactacc actaatagct gagacccact 60 ccagcccctt ccc 73 < 210 > 352 < 211 > 25 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DP 47 _ CDR 2 _ fo < 400 > 352 acatactacg cagactccgt gaagg 25