< 110 > Nuclixbio < 120 > Aptamer for KRAS and use thereof < 130 > PN 133387 < 150 > KR 10 - 2019 - 0083440 < 151 > 2019 - 07 - 10 < 160 > 8 < 170 > KoPatentIn 3 . 0 < 210 > 1 < 211 > 42 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > common sequence of aptamer sequence of NBK 1 and NBK 1 - 1 < 220 > < 221 > misc _ feature < 222 > ( 7 ) . .( 8 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 19 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 27 ) . .( 32 ) < 223 > each n is A , T , G or C < 400 > 1 atcatgnncc gggttcggnt ggggggnnnn nncatgatct ac 42 < 210 > 2 < 211 > 40 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > common sequence of aptamer sequence of NBK 2 and NBK 2 - 1 < 220 > < 221 > misc _ feature < 222 > ( 1 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 13 ) . .( 14 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 19 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 25 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 39 ) < 223 > each n is A , T , G or C < 400 > 2 ncggtacgtc cgnntatgng tgggnggtaa gggagaccnc 40 < 210 > 3 < 211 > 86 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > aptamer sequence of NBK 1 < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 12 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 15 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 19 ) . .( 20 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 28 ) . .( 29 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 40 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 48 ) . .( 53 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 74 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 78 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 81 ) . .( 86 ) < 223 > each n is A , T , G or C < 400 > 3 nnnnnnnnnn nnggncatnn gatcatgnnc cgggttcggn tggggggnnn nnncatgatc 60 tacttgacta gtanatgncc nnnnnn 86 < 210 > 4 < 211 > 63 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > aptamer sequence of NBK 1 - 1 < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 8 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 16 ) . .( 17 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 28 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 36 ) . .( 41 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 61 ) . .( 63 ) < 223 > each n is A , T , G or C < 400 > 4 nnnnnnnnga tcatgnnccg ggttcggntg gggggnnnnn ncatgatcta cttgactagt 60 nnn 63 < 210 > 5 < 211 > 86 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > aptamer sequence of NBK 2 < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 15 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 20 ) . .( 24 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 36 ) . .( 37 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 42 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 48 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 62 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 64 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 76 ) . .( 78 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 83 ) . .( 86 ) < 223 > each n is A , T , G or C < 400 > 5 nnnnnnnnnn nnnnncatan nnnncggtac gtccgnntat gngtgggngg taagggagac 60 cncntgacta gtacannncc acnnnn 86 < 210 > 6 < 211 > 69 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > aptamer sequence of NBK 2 - 1 < 220 > < 221 > misc _ feature < 222 > ( 1 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 6 ) . .( 10 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 22 ) . .( 23 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 28 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 34 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 48 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 50 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 62 ) . .( 64 ) < 223 > each n is A , T , G or C < 220 > < 221 > misc _ feature < 222 > ( 69 ) < 223 > each n is A , T , G or C < 400 > 6 ncatannnnn cggtacgtcc gnntatgngt gggnggtaag ggagaccncn tgactagtac 60 annnccacn 69 < 210 > 7 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > forward primer sequence < 400 > 7 gtagttggag ctgatggcgt aggcaag 27 < 210 > 8 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > reverse primer sequence < 400 > 8 cttgcctacg ccatcagctc caactac 27