< 110 > CJ Corporation < 120 > Ammonia specific 5 '- XMP aminase mutant < 160 > 28 < 170 > KopatentIn 1 . 71 < 210 > 1 < 211 > 1578 < 212 > DNA < 213 > Escherichia coli K 12 < 220 > < 221 > gene < 222 > ( 1 ) . .( 1578 ) < 223 > DNA sequence for XMP aminase wild type gene G 1 ( guaA ) < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > amino acid sequence of XMP aminase wild type G 1 < 400 > 1 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ctg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca agc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt tgc tat ggc atg cag acc atg gca atg cag ttg 288 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Ala Met Gln Leu 85 90 95 ggc ggt cac gtt gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gtt gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg tcc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt atg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Met Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtc atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aaa aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gac gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gaa gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg gta cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Val Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat gac tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 2 < 211 > 525 < 212 > PRT < 213 > Escherichia coli K 12 < 400 > 2 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Ala Met Gln Leu 85 90 95 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Met Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Val Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 3 < 211 > 1578 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DNA sequence of mutant G 3 < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > amino acid sequence of XMP aminase mutant G 3 < 400 > 3 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ttg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca tgc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Cys Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt tgc tat ggc atg cag acc atg gca atg cag ttg 288 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Ala Met Gln Leu 85 90 95 ggc ggt cac gtt gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gtt gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg tcc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt acg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtc atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aga aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Arg Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gac gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gaa gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg ata cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat gac tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 4 < 211 > 525 < 212 > PRT < 213 > Artificial Sequence < 400 > 4 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Cys Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Ala Met Gln Leu 85 90 95 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Arg Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 5 < 211 > 1578 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Artificial sequence < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > amino acid sequence of XMP aminase mutant F 12 < 400 > 5 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ctg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca agc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt tgc tat ggc atg cag acc atg gta atg cag ttg 288 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 ggc ggt cac gtt gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gtt gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg ccc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Pro Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt atg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Met Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtc atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aaa aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gat gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gag gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg ata cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat gac tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 6 < 211 > 525 < 212 > PRT < 213 > Artificial Sequence < 400 > 6 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Pro Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Met Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 7 < 211 > 1578 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Artificial sequence < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > amino acid sequence of XMP aminase mutant F 63 < 400 > 7 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ctg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca agc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt tgc tat ggc atg cag acc atg gta atg cag ttg 288 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 ggc ggt cac att gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Ile Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gct gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Ala Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg tcc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt acg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtt atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aaa aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gac gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gaa gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg ata cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat ggc tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Gly Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 8 < 211 > 525 < 212 > PRT < 213 > Artificial Sequence < 400 > 8 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 Gly Gly His Ile Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Ala Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Gly Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 9 < 211 > 1578 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DNA sequence of G 3 - 1 < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > Amino acid of G 3 - 1 < 400 > 9 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ttg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca tgc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Cys Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt tgc tat ggc atg cag acc atg gca atg cag ttg 288 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Ala Met Gln Leu 85 90 95 ggc ggt cac gtt gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gtt gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg tcc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt acg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtc atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aga aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Arg Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gac gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gaa gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg ata cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat gac tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 10 < 211 > 525 < 212 > PRT < 213 > Artificial Sequence < 400 > 10 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Cys Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Ala Met Gln Leu 85 90 95 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Arg Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 11 < 211 > 1578 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DNA sequence of F 12 - 1 < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > Amino acid sequence of F 12 - 1 < 400 > 11 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ctg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca agc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt tgc tat ggc atg cag acc atg gta atg cag ttg 288 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 ggc ggt cac gtt gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gtt gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg ccc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Pro Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt atg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Met Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtc atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aaa aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gat gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gag gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg ata cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat gac tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 12 < 211 > 525 < 212 > PRT < 213 > Artificial Sequence < 400 > 12 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Pro Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Met Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 13 < 211 > 1578 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DNA sequence of F 63 - 1 < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > Amino acid sequence of F 63 - 1 < 400 > 13 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ctg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca agc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt tgc tat ggc atg cag acc atg gta atg cag ttg 288 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 ggc ggt cac att gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Ile Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gct gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Ala Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg tcc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt acg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtt atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aaa aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gac gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gaa gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg ata cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat ggc tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Gly Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 14 < 211 > 525 < 212 > PRT < 213 > Artificial Sequence < 400 > 14 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Cys Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 Gly Gly His Ile Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Ala Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Gly Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 15 < 211 > 1578 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DNA sequence of G 1 C < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > Amino acid sequence of G 1 C < 400 > 15 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ctg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca agc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt gca tat ggc atg cag acc atg gca atg cag ttg 288 Pro Val Phe Gly Val Ala Tyr Gly Met Gln Thr Met Ala Met Gln Leu 85 90 95 ggc ggt cac gtt gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gtt gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg tcc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt atg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Met Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtc atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aaa aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gac gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gaa gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg gta cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Val Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat gac tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 16 < 211 > 525 < 212 > PRT < 213 > Artificial Sequence < 400 > 16 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Ala Tyr Gly Met Gln Thr Met Ala Met Gln Leu 85 90 95 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Met Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Val Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 17 < 211 > 1578 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DNA sequence of G 3 C < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > Amino acid sequence of G 3 C < 400 > 17 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ttg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca tgc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Cys Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt gca tat ggc atg cag acc atg gca atg cag ttg 288 Pro Val Phe Gly Val Ala Tyr Gly Met Gln Thr Met Ala Met Gln Leu 85 90 95 ggc ggt cac gtt gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gtt gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg tcc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt acg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtc atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aga aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Arg Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gac gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gaa gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg ata cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat gac tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 18 < 211 > 525 < 212 > PRT < 213 > Artificial Sequence < 400 > 18 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Cys Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Ala Tyr Gly Met Gln Thr Met Ala Met Gln Leu 85 90 95 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Arg Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 19 < 211 > 1578 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DNA sequence of F 12 C < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > Amino acid sequence of F 12 C < 400 > 19 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ctg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca agc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt gca tat ggc atg cag acc atg gta atg cag ttg 288 Pro Val Phe Gly Val Ala Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 ggc ggt cac gtt gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gtt gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg ccc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Pro Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt atg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Met Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtc atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aaa aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gat gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gag gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg ata cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat gac tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 20 < 211 > 525 < 212 > PRT < 213 > Artificial Sequence < 400 > 20 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Ala Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 Gly Gly His Val Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Val Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Pro Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Met Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Asp Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 21 < 211 > 1578 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > DNA sequence of F 63 C < 220 > < 221 > CDS < 222 > ( 1 ) . .( 1575 ) < 223 > Amino acid sequence of F 63 C < 400 > 21 atg acg gaa aac att cat aag cat cgc atc ctc att ctg gac ttc ggt 48 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 tct cag tac act caa ctg gtt gcg cgc cgc gtg cgt gag ctg ggt gtt 96 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 tac tgc gaa ctg tgg gcg tgg gat gtg aca gaa gca caa att cgt gac 144 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 ttc aat cca agc ggc att att ctt tcc ggc ggc ccg gaa agt act act 192 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 gaa gaa aac agt ccg cgt gcg ccg cag tat gtc ttt gaa gca ggc gta 240 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 ccg gta ttc ggc gtt gca tat ggc atg cag acc atg gta atg cag ttg 288 Pro Val Phe Gly Val Ala Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 ggc ggt cac att gaa gcc tct aac gaa cgt gaa ttt ggc tac gcg cag 336 Gly Gly His Ile Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 gct gaa gtc gta aac gac agc gca ctg gtt cgc ggt atc gaa gat gcg 384 Ala Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 ctg acc gca gac ggt aaa ccg ctg ctc gat gtc tgg atg agc cac ggc 432 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 gat aaa gtt acc gct att ccg tcc gac ttc atc acc gta gcc agc acc 480 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 gaa agc tgc ccg ttt gcc att atg gct aac gaa gaa aaa cgc ttc tat 528 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 ggc gta cag ttc cac ccg gaa gtg act cat acc cgc cag ggt acg cgc 576 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 atg ctg gag cgt ttt gtg cgt gat atc tgc cag tgt gaa gcc ctg tgg 624 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 acg cca gcg aaa att atc gac gat gct gta gct cgc atc cgc gag cag 672 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 gta ggc gac gat aaa gtt atc ctc ggc ctc tct ggt ggt gtg gat tcc 720 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 tcc gta acc gca atg ctg ctg cac cgc gct atc ggt aaa aac ctg act 768 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 tgc gta ttc gtc gac aac ggc ctg ctg cgc ctc aac gaa gca gag cag 816 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 gtt ctg gat atg ttt ggc gat cac ttt ggt ctt aac att gtt cac gta 864 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 ccg gca gaa gat cgc ttc ctg tca gcg ctg gct ggc gaa aac gat ccg 912 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 gaa gca aaa cgt aaa atc atc ggt cgc gtt ttc gtt gaa gta ttc gat 960 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 gaa gaa gcg ctg aaa ctg gaa gac gtg aag tgg ctg gcg cag ggc acc 1008 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 atc tac cct gac gtt atc gaa tct gcg gcg tct gca acc ggt aaa gca 1056 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 cac gtc atc aaa tct cac cac aac gtg ggc ggc ctg ccg aaa gag atg 1104 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 aag atg ggc ctg gtt gaa ccg ctg aaa gag ctg ttc aaa gac gaa gtg 1152 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 cgt aag att ggt ctg gag ctg ggc ctg ccg tac gac atg ctg tac cgt 1200 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 cac ccg ttc ccg gga cca ggc ctt ggc gtt cgt gtt ctg ggt gaa gtg 1248 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 aag aaa gag tac tgt gac ctg ctg cgc cgt gct gac gcc atc ttc att 1296 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 gaa gaa ctg cgt aaa gcg gac ctg tac gac aaa gtc agc cag gcg ttc 1344 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 act gtg ttc ctg ccg ata cgt tcc gtt ggc gta atg ggc gat ggt cgt 1392 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 aag tat ggc tgg gtt gtc tct ctg cgt gct gtc gaa acc atc gac ttt 1440 Lys Tyr Gly Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 atg acc gca cac tgg gcg cat ctg ccg tac gat ttc ctc ggt cgc gtt 1488 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 tcc aac cgc att atc aat gaa gtg aac ggt att tcc cgc gtg gtg tat 1536 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 gac atc agc ggc aag ccg cca gct acc att gag tgg gaa tga 1578 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 22 < 211 > 525 < 212 > PRT < 213 > Artificial Sequence < 400 > 22 Met Thr Glu Asn Ile His Lys His Arg Ile Leu Ile Leu Asp Phe Gly 1 5 10 15 Ser Gln Tyr Thr Gln Leu Val Ala Arg Arg Val Arg Glu Leu Gly Val 20 25 30 Tyr Cys Glu Leu Trp Ala Trp Asp Val Thr Glu Ala Gln Ile Arg Asp 35 40 45 Phe Asn Pro Ser Gly Ile Ile Leu Ser Gly Gly Pro Glu Ser Thr Thr 50 55 60 Glu Glu Asn Ser Pro Arg Ala Pro Gln Tyr Val Phe Glu Ala Gly Val 65 70 75 80 Pro Val Phe Gly Val Ala Tyr Gly Met Gln Thr Met Val Met Gln Leu 85 90 95 Gly Gly His Ile Glu Ala Ser Asn Glu Arg Glu Phe Gly Tyr Ala Gln 100 105 110 Ala Glu Val Val Asn Asp Ser Ala Leu Val Arg Gly Ile Glu Asp Ala 115 120 125 Leu Thr Ala Asp Gly Lys Pro Leu Leu Asp Val Trp Met Ser His Gly 130 135 140 Asp Lys Val Thr Ala Ile Pro Ser Asp Phe Ile Thr Val Ala Ser Thr 145 150 155 160 Glu Ser Cys Pro Phe Ala Ile Met Ala Asn Glu Glu Lys Arg Phe Tyr 165 170 175 Gly Val Gln Phe His Pro Glu Val Thr His Thr Arg Gln Gly Thr Arg 180 185 190 Met Leu Glu Arg Phe Val Arg Asp Ile Cys Gln Cys Glu Ala Leu Trp 195 200 205 Thr Pro Ala Lys Ile Ile Asp Asp Ala Val Ala Arg Ile Arg Glu Gln 210 215 220 Val Gly Asp Asp Lys Val Ile Leu Gly Leu Ser Gly Gly Val Asp Ser 225 230 235 240 Ser Val Thr Ala Met Leu Leu His Arg Ala Ile Gly Lys Asn Leu Thr 245 250 255 Cys Val Phe Val Asp Asn Gly Leu Leu Arg Leu Asn Glu Ala Glu Gln 260 265 270 Val Leu Asp Met Phe Gly Asp His Phe Gly Leu Asn Ile Val His Val 275 280 285 Pro Ala Glu Asp Arg Phe Leu Ser Ala Leu Ala Gly Glu Asn Asp Pro 290 295 300 Glu Ala Lys Arg Lys Ile Ile Gly Arg Val Phe Val Glu Val Phe Asp 305 310 315 320 Glu Glu Ala Leu Lys Leu Glu Asp Val Lys Trp Leu Ala Gln Gly Thr 325 330 335 Ile Tyr Pro Asp Val Ile Glu Ser Ala Ala Ser Ala Thr Gly Lys Ala 340 345 350 His Val Ile Lys Ser His His Asn Val Gly Gly Leu Pro Lys Glu Met 355 360 365 Lys Met Gly Leu Val Glu Pro Leu Lys Glu Leu Phe Lys Asp Glu Val 370 375 380 Arg Lys Ile Gly Leu Glu Leu Gly Leu Pro Tyr Asp Met Leu Tyr Arg 385 390 395 400 His Pro Phe Pro Gly Pro Gly Leu Gly Val Arg Val Leu Gly Glu Val 405 410 415 Lys Lys Glu Tyr Cys Asp Leu Leu Arg Arg Ala Asp Ala Ile Phe Ile 420 425 430 Glu Glu Leu Arg Lys Ala Asp Leu Tyr Asp Lys Val Ser Gln Ala Phe 435 440 445 Thr Val Phe Leu Pro Ile Arg Ser Val Gly Val Met Gly Asp Gly Arg 450 455 460 Lys Tyr Gly Trp Val Val Ser Leu Arg Ala Val Glu Thr Ile Asp Phe 465 470 475 480 Met Thr Ala His Trp Ala His Leu Pro Tyr Asp Phe Leu Gly Arg Val 485 490 495 Ser Asn Arg Ile Ile Asn Glu Val Asn Gly Ile Ser Arg Val Val Tyr 500 505 510 Asp Ile Ser Gly Lys Pro Pro Ala Thr Ile Glu Trp Glu 515 520 525 < 210 > 23 < 211 > 29 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > primer for mutagenesis of guaA < 400 > 23 cgcgaattca tgacggaaaa cattcataa 29 < 210 > 24 < 211 > 28 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > primer for mutagenesis of guaA < 400 > 24 ctagtctaga tcattcccac tcaatggt 28 < 210 > 25 < 211 > 32 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > primer for mutagenesis of guaA < 400 > 25 acgtgccggc atgacggaaa acattcataa gc 32 < 210 > 26 < 211 > 31 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > primer for mutagenesis of guaA < 400 > 26 acgtggatcc tcattcccac tcaatggtag c 31 < 210 > 27 < 211 > 36 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > primer for mutagenesis of guaA < 400 > 27 ccggtattcg gcgttgcata tggcatgcag accatg 36 < 210 > 28 < 211 > 36 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > primer for mutagenesis of guaA < 400 > 28 catggtctgc atgccatatg caacgccgaa taccgg 36