You might consider trying ayuhasca spelling ? . It ' s SUPPOSED to be really good at helping to treat depression , but you should look into all that for yourself . I ' ve personally done mushrooms and lsd , and the mushrooms really helped me a lot with my depression and anxiety . It allowed me to just stop and really think and analyze all my negative thoughts , as if they were pulled from my mind and laid bare in front of me almost like I was beside myself and was able to understand why I felt the way I did . That was my personal experience and yours could obviously differ . As always , be safe . research what your getting into , and make sure you can trust whoever it is your getting the substances from . Talk to others who ' ve consumed said substance for their opinion on its effectsany side effects if present . Place yourself in a safe and familiar environment , and always , ALWAYS . have a friend nearby who can keep and eye on you and can help you , should anything go wrong . Never do stuff like that alone , in case of panic attack , a freak out , vomiting . just to be safe . Anyway , that ' s my opinion based off my own , as well as close friend ' s experiences doing lsdmushrooms . Most importantly . Be safe , Have fun and stay hydrated ! !