SEQUENCE LISTING < 110 > ZymoGenetics , Inc . Jaspers , Stephen R . Rixon , Mark W . Dillon , Stacey R . Ramsdell , Frederick J . Cecile M . Krejsa Eugene Yi < 120 > ANTI - HUMAN IL - 21 MONOCLONAL ANTIBODIES < 130 > 07 - 16 PC < 140 > PCT / IB 2008 / 005011 < 141 > 2008 - 12 - 08 < 150 > 61 / 012 , 329 < 151 > 2007 - 12 - 07 < 160 > 97 < 170 > FastSEQ for Windows Version 4 . 0 < 210 > 1 < 211 > 642 < 212 > DNA < 213 > Homo sapiens < 400 > 1 gctgaagtga aaacgagacc aaggtctagc tctactgttg gtacttatga gatccagtcc 60 tggcaacatg gagaggattg tcatctgtct gatggtcatc ttcttgggga cactggtcca 120 caaatcaagc tcccaaggtc aagatcgcca catgattaga atgcgtcaac ttatagatat 180 tgttgatcag ctgaaaaatt atgtgaatga cttggtccct gaatttctgc cagctccaga 240 agatgtagag acaaactgtg agtggtcagc tttttcctgt tttcagaagg cccaactaaa 300 gtcagcaaat acaggaaaca atgaaaggat aatcaatgta tcaattaaaa agctgaagag 360 gaaaccacct tccacaaatg cagggagaag acagaaacac agactaacat gcccttcatg 420 tgattcttat gagaaaaaac cacccaaaga attcctagaa agattcaaat cacttctcca 480 aaagatgatt catcagcatc tgtcctctag aacacacgga agtgaagatt cctgaggatc 540 taacttgcag ttggacacta tgttacatac tctaatatag tagtgaaagt catttctttg 600 tattccaagt ggaggagccc tattaaatta tataaagaaa ta 642 < 210 > 2 < 211 > 162 < 212 > PRT < 213 > Homo sapiens < 400 > 2 Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 1 5 10 15 Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 20 25 30 Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 35 40 45 Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 50 55 60 Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 65 70 75 80 Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 85 90 95 Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 100 105 110 Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 115 120 125 Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 130 135 140 Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 145 150 155 160 Asp Ser < 210 > 3 < 211 > 21 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > IL - 21 synthetic peptide # 1 < 400 > 3 Glu Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val 1 5 10 15 Asp Gln Leu Lys Cys 20 < 210 > 4 < 211 > 19 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > IL - 21 synthetic peptide # 2 < 400 > 4 Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Asn 1 5 10 15 Thr Asn Cys < 210 > 5 < 211 > 26 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > IL - 21 synthetic peptide # 3 < 400 > 5 Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 1 5 10 15 Gly Arg Arg Gln Lys His Arg Leu Thr Cys 20 25 < 210 > 6 < 211 > 29 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > IL - 21 synthetic peptide # 4 < 400 > 6 Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 1 5 10 15 Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser 20 25 < 210 > 7 < 211 > 162 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Mutant recombinant IL - 21 aa < 400 > 7 Met Asp Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 1 5 10 15 Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 20 25 30 Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 35 40 45 Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 50 55 60 Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 65 70 75 80 Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 85 90 95 Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 100 105 110 Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 115 120 125 Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 130 135 140 Asp Lys Met Asp His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 145 150 155 160 Asp Ser < 210 > 8 < 211 > 545 < 212 > DNA < 213 > Macaca fascicularis < 400 > 8 cgagaccaag gtctagctct actgttggta cttatgagat ccagtcctgg caacatggag 60 aggatagtca tctgtctgat ggtcatcttc ttggggacac tggtccacaa atcaagctcc 120 caaggtcaag atcgccacat gattagaatg cgtcaactta tagatattgt tgatcagctg 180 aaaaattatg tgaatgactt ggaccctgaa tttctgccag ctccagaaga tgtagagaca 240 aactgtgagt ggtcagctat ttcctgtttt cagaaggccc aactaaagtc agcaaataca 300 ggaaacaatg aaaggataat caatttatca attaaaaagc tgaagaggaa atcaccttcc 360 acaggtgcag agagaagaca gaaacacaga ctaacatgcc cttcatgtga ttcttatgag 420 aaaaaaccac ccaaagaatt cctagaaaga ttcaaatcac ttctccaaaa gatgattcat 480 cagcatctgt cctctagaac acatggaagt gaagattcct gaggatctaa cttgcagttg 540 gacac 545 < 210 > 9 < 211 > 162 < 212 > PRT < 213 > Macaca fascicularis < 400 > 9 Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 1 5 10 15 Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 20 25 30 Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 35 40 45 Leu Lys Asn Tyr Val Asn Asp Leu Asp Pro Glu Phe Leu Pro Ala Pro 50 55 60 Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Ile Ser Cys Phe Gln 65 70 75 80 Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 85 90 95 Asn Leu Ser Ile Lys Lys Leu Lys Arg Lys Ser Pro Ser Thr Gly Ala 100 105 110 Glu Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 115 120 125 Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 130 135 140 Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 145 150 155 160 Asp Ser < 210 > 10 < 211 > 3072 < 212 > DNA < 213 > Mus Musculus < 400 > 10 gagaaccaga ccaaggccct gtcatcagct cctggagact cagttctggt ggcatggaga 60 ggacccttgt ctgtctggta gtcatcttct tggggacagt ggcccataaa tcaagccccc 120 aagggccaga tcgcctcctg attagacttc gtcaccttat tgacattgtt gaacagctga 180 aaatctatga aaatgacttg gatcctgaac ttctatcagc tccacaagat gtaaaggggc 240 actgtgagca tgcagctttt gcctgttttc agaaggccaa actcaagcca tcaaaccctg 300 gaaacaataa gacattcatc attgacctcg tggcccagct caggaggagg ctgcctgcca 360 ggaggggagg aaagaaacag aagcacatag ctaaatgccc ttcctgtgat tcgtatgaga 420 aaaggacacc caaagaattc ctagaaagac taaaatggct ccttcaaaag atgattcatc 480 agcatctctc ctagaacaca taggacccga agattcctga ggatccgaga agattcccga 540 ggactgagga gacgccggac actatagacg ctcacgaatg caggagtaca tcttgcctct 600 tgggattgca agtggagaag tacgatacgt tatgataaga acaactcaga aaagctatag 660 gttaagatcc tttcgcccat taactaagca gacattgtgg ttccctgcac agactccatg 720 ctgtcaacat ggaaaatctc aactcaacaa gagcccagct tcccgtgtca gggatttctg 780 gtgcttctca agctgtggct tcatcttatt gcccaactgt gacattcttt gattggaagg 840 ggaaaactaa agcttttagc aaaaatacag ctagggaatt tgtcgatctg cgagagtaag 900 acctcttatg atcctaacgg aatgatgtaa gctggaaata ataagcataa gatgaaattg 960 aaaattgaag tctttattct ttaagaaaaa ctttgtactt gaaagcatgt ctgaagagtt 1020 tactcattac cacaaacatc tagcatattg ataactaaca tctttatact ctacaagaga 1080 ggctttccag ataggtacag tttttcttct ctattaggtc tatcaaaatt taacctatta 1140 tgagggtcac ccctggcttt cactgttttt ctaaagaggc aagggtgtag taagaagcag 1200 gcttaagttg ccttcctccc aatgtcaagt tcctttataa gctaatagtt taatcttgtg 1260 aagatggcaa tgaaagcctg tggaagtgca aacctcacta tcttctggag ccaagtagaa 1320 ttttcaagtt tgtagctctc acctcaagtg gttatgggtg tcctgtgatg aatctgctag 1380 ctccagcctc agtctcctct cccacatcct ttcctttctt tcctctttga aacttctaag 1440 aaaaagcaat ccaaacaagt tcagcactta agacacattg catgcacact tttgataagt 1500 taaatccaac catctattta aaatcaaaat caggagatga gccaagagac cagaggttct 1560 gttccagttt taaacagact tttactgaac atcccaatct tttaaccaca gaggctaaat 1620 tgagcaaata gttttgccat ttgatataat ttccaacagt atgtttcaat gtcaagttaa 1680 aaagtctaca aagctatttt ccctggagtg gtatcatcgc tttgagaatt tcttatggtt 1740 aaaatggatc tgagatccaa gcatggcctg ggggatggtt ttgatctaag gaaaaaggtg 1800 tctgtacctc acagtgcctt taaaacaagc agagatcccg tgtaccgccc taagatagca 1860 cagactagtg ttaactgatt cccagaaaag tgtcacaatc agaaccaacg cattctctta 1920 aactttaaaa atatgtattg caaagaactt gtgtaactgt aaatgtgtga ctgttgatga 1980 cattatacac acatagccca cgtaagtgtc caatggtgct agcattggtt gctgagtttg 2040 ctgctcgaaa gctgaagcag agatgcagtc cttcacaaag caatgatgga cagagagggg 2100 agtctccatg ttttattctt ttgttgtttc tggctgtgta actgttgact tcttgacatt 2160 gtgattttta tatttaagac aatgtattta ttttggtgtg tttattgttc tagcctttta 2220 aatcactgac aatttctaat caagaagtac aaataattca atgcagcaca ggctaagagc 2280 ttgtatcgtt tggaaaagcc agtgaaggct tctccactag ccatgggaaa gctacgcttt 2340 agagtaaact agacaaaatt gcacagcagt cttgaacctc tctgtgctca agactcagcc 2400 agtcctttga cattattgtt cactgtgggt gggaacacat tggacctgac acactgttgt 2460 gtgtccatga aggttgccac tggtgtaagc tttttttggt tttcattctc ttatctgtag 2520 aacaagaatg tggggctttc ctaagtctat tctgtatttt attctgaact tcgtatgtct 2580 gagttttaat gttttgagta ctcttacagg aacacctgac cacacttttg agttaaattt 2640 tatcccaagt gtgatattta gttgttcaaa aagggaaggg atatacatac atacatacat 2700 acatacatac atatatatat atatatatac atatatatat atatatatat gtatatatat 2760 atatatatag agagagagag agagagagag agagaaagag agagaggttg ttgtaggtca 2820 taggagttca gaggaaatca gttatggccg ttaatactgt agctgaaagt gttttctttg 2880 tgaataaatt catagcatta ttgatctatg ttattgctct gttttattta cagtcacacc 2940 tgagaattta gttttaatat gaatgatgta ctttataact taatgattat ttattatgta 3000 tttggttttg aatgtttgtg ttcatggctt cttatttaag acctgatcat attaaatgct 3060 acccagtccg ga 3072 < 210 > 11 < 211 > 146 < 212 > PRT < 213 > Mus musculus < 400 > 11 Met Glu Arg Thr Leu Val Cys Leu Val Val Ile Phe Leu Gly Thr Val 1 5 10 15 Ala His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu 20 25 30 Arg His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp 35 40 45 Leu Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys 50 55 60 Glu His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser 65 70 75 80 Asn Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu 85 90 95 Arg Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile 100 105 110 Ala Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu 115 120 125 Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His 130 135 140 Leu Ser 145 < 210 > 12 < 211 > 423 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 423 ) < 400 > 12 atg aag cac ctg tgg ttc ttc ctc ctg ctg gtg gcg gct ccc aga tgg 48 Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 1 5 10 15 gtc ctg tcc cag cta caa ctg cag gag tcg ggc cca gga ctg gtg aag 96 Val Leu Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 20 25 30 cct tcg gag acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc 144 Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 35 40 45 agc agt agg act tac cgc tgg ggc tgg atc cgc cag ccc cca ggg aag 192 Ser Ser Arg Thr Tyr Arg Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys 50 55 60 gaa ctg gag tgg att ggg agt atc tat tat aga ggg agt acc ttc tac 240 Glu Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Arg Gly Ser Thr Phe Tyr 65 70 75 80 aac ccg tcc ctc aag agt cga gtc acc gta tcc gta gac acg tcc aag 288 Asn Pro Ser Leu Lys Ser Arg Val Thr Val Ser Val Asp Thr Ser Lys 85 90 95 aac cag ttc tcc ctg aaa ctg agc tct gtg acc gcc gca gac acg gct 336 Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 100 105 110 gtg tat tac tgt gcg aga cag agt gga tat agt ggc tac gac tgg ttc 384 Val Tyr Tyr Cys Ala Arg Gln Ser Gly Tyr Ser Gly Tyr Asp Trp Phe 115 120 125 gac ccc tgg ggc cag gga acc ctg gtc acc gtc tcc tca 423 Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 130 135 140 < 210 > 13 < 211 > 141 < 212 > PRT < 213 > Homo sapiens < 400 > 13 Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 1 5 10 15 Val Leu Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 20 25 30 Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 35 40 45 Ser Ser Arg Thr Tyr Arg Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys 50 55 60 Glu Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Arg Gly Ser Thr Phe Tyr 65 70 75 80 Asn Pro Ser Leu Lys Ser Arg Val Thr Val Ser Val Asp Thr Ser Lys 85 90 95 Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 100 105 110 Val Tyr Tyr Cys Ala Arg Gln Ser Gly Tyr Ser Gly Tyr Asp Trp Phe 115 120 125 Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 130 135 140 < 210 > 14 < 211 > 21 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 21 ) < 400 > 14 agt agg act tac cgc tgg ggc 21 Ser Arg Thr Tyr Arg Trp Gly 1 5 < 210 > 15 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 15 Ser Arg Thr Tyr Arg Trp Gly 1 5 < 210 > 16 < 211 > 48 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 48 ) < 400 > 16 agt atc tat tat aga ggg agt acc ttc tac aac ccg tcc ctc aag agt 48 Ser Ile Tyr Tyr Arg Gly Ser Thr Phe Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 17 < 211 > 16 < 212 > PRT < 213 > Homo sapiens < 400 > 17 Ser Ile Tyr Tyr Arg Gly Ser Thr Phe Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 18 < 211 > 36 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 36 ) < 400 > 18 cag agt gga tat agt ggc tac gac tgg ttc gac ccc 36 Gln Ser Gly Tyr Ser Gly Tyr Asp Trp Phe Asp Pro 1 5 10 < 210 > 19 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 400 > 19 Gln Ser Gly Tyr Ser Gly Tyr Asp Trp Phe Asp Pro 1 5 10 < 210 > 20 < 211 > 378 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 378 ) < 400 > 20 atg gaa gcc cca gct cag ctt ctc ttc ctc ctg cta ctc tgg ctc cca 48 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 gat acc acc gga gaa att gtg ttg aca cag tct cca gcc acc ctg tct 96 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 ttg tct cca ggg gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt 144 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 35 40 45 gtt agc agc ttc tta gcc tgg tac caa cag aaa cct ggc cag gct ccc 192 Val Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 agg ctc ctc atc tat gat gca tcc aac agg gcc act ggc atc cca gcc 240 Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 65 70 75 80 agg ttc agt ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc 288 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 agc cta gag cct gaa gat ttt gca gtt tat tac tgt cag cag cgt agc 336 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 100 105 110 aac tgg atc acc ttc ggc caa ggg aca cga ctg gag att aaa 378 Asn Trp Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 115 120 125 < 210 > 21 < 211 > 126 < 212 > PRT < 213 > Homo sapiens < 400 > 21 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 35 40 45 Val Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 50 55 60 Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 85 90 95 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 100 105 110 Asn Trp Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 115 120 125 < 210 > 22 < 211 > 33 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 33 ) < 400 > 22 agg gcc agt cag agt gtt agc agc ttc tta gcc 33 Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 1 5 10 < 210 > 23 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 23 Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 1 5 10 < 210 > 24 < 211 > 21 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 21 ) < 400 > 24 gat gca tcc aac agg gcc act 21 Asp Ala Ser Asn Arg Ala Thr 1 5 < 210 > 25 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 25 Asp Ala Ser Asn Arg Ala Thr 1 5 < 210 > 26 < 211 > 24 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 24 ) < 400 > 26 cag cag cgt agc aac tgg atc acc 24 Gln Gln Arg Ser Asn Trp Ile Thr 1 5 < 210 > 27 < 211 > 8 < 212 > PRT < 213 > Homo sapiens < 400 > 27 Gln Gln Arg Ser Asn Trp Ile Thr 1 5 < 210 > 28 < 211 > 435 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 435 ) < 400 > 28 atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt 48 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 gtc cag tgt cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag 96 Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 20 25 30 cct ggg agg tcc ctg aga ctc tcc tgt gca gcg tct gga ttc acc ttc 144 Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 35 40 45 agt agc tat ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg 192 Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 gag tgg gtg gcg ttt ata tgg tat gat gga agt gat aaa tac tat gca 240 Glu Trp Val Ala Phe Ile Trp Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala 65 70 75 80 gac tct gtg aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac 288 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 85 90 95 acg ctg tat ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg 336 Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 tat tac tgt gcg aga gat ggg gat agc agt gac tgg tac ggg gac tac 384 Tyr Tyr Cys Ala Arg Asp Gly Asp Ser Ser Asp Trp Tyr Gly Asp Tyr 115 120 125 tac ttc ggt atg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc 432 Tyr Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 130 135 140 tca 435 Ser 145 < 210 > 29 < 211 > 145 < 212 > PRT < 213 > Homo sapiens < 400 > 29 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 20 25 30 Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 35 40 45 Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Val Ala Phe Ile Trp Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala 65 70 75 80 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 85 90 95 Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Arg Asp Gly Asp Ser Ser Asp Trp Tyr Gly Asp Tyr 115 120 125 Tyr Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 130 135 140 Ser 145 < 210 > 30 < 211 > 16 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 16 ) < 400 > 30 agc tat ggc atg cac t 16 Ser Tyr Gly Met His 1 5 < 210 > 31 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 31 Ser Tyr Gly Met His 1 5 < 210 > 32 < 211 > 51 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 51 ) < 400 > 32 ttt ata tgg tat gat gga agt gat aaa tac tat gca gac tct gtg aag 48 Phe Ile Trp Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 ggc 51 Gly < 210 > 33 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 33 Phe Ile Trp Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 34 < 211 > 51 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 51 ) < 400 > 34 gat ggg gat agc agt gac tgg tac ggg gac tac tac ttc ggt atg gac 48 Asp Gly Asp Ser Ser Asp Trp Tyr Gly Asp Tyr Tyr Phe Gly Met Asp 1 5 10 15 gtc 51 Val < 210 > 35 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 35 Asp Gly Asp Ser Ser Asp Trp Tyr Gly Asp Tyr Tyr Phe Gly Met Asp 1 5 10 15 Val < 210 > 36 < 211 > 378 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 378 ) < 400 > 36 atg gaa acc cca gcg cag ctt ctc ttc ctc ctg cta ctc tgg ctc cca 48 Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 gat acc acc gga gaa att gtg ttg acg cag tct cca ggc acc ctg tct 96 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 20 25 30 ttg tct cca ggg gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt 144 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 35 40 45 gtt agc agc agc tac tta gcc tgg tac cag cag aaa cct ggc cag gct 192 Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 50 55 60 ccc agg ctc ctc atc tat ggt gca tcc agc agg gcc act ggc atc cca 240 Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 65 70 75 80 gac agg ttc agt ggc agt ggg tct ggg aca gac ttc act ctc acc atc 288 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 85 90 95 agc aga ctg gag cct gaa gat ttt gca gtg tat tac tgt cag cag tat 336 Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 100 105 110 ggt agc tgg acg ttc ggc caa ggg acc aag gtg gaa atc aaa 378 Gly Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 37 < 211 > 126 < 212 > PRT < 213 > Homo sapiens < 400 > 37 Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 35 40 45 Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 50 55 60 Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 85 90 95 Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 100 105 110 Gly Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 38 < 211 > 36 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 36 ) < 400 > 38 agg gcc agt cag agt gtt agc agc agc tac tta gcc 36 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 39 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 400 > 39 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 40 < 211 > 21 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 21 ) < 400 > 40 ggt gca tcc agc agg gcc act 21 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 41 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 41 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 42 < 211 > 21 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 21 ) < 400 > 42 cag cag tat ggt agc tgg acg 21 Gln Gln Tyr Gly Ser Trp Thr 1 5 < 210 > 43 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 43 Gln Gln Tyr Gly Ser Trp Thr 1 5 < 210 > 44 < 211 > 435 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 435 ) < 400 > 44 atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt 48 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 gtc cag tgt cag gtg cag ctg gtg gaa tct ggg gga ggc gtg gtc cag 96 Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 20 25 30 cct ggg agg tcc ctg aga ctc tcc tgt gca gcg tct gga ttc acc ttc 144 Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 35 40 45 agt acc tat ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg 192 Ser Thr Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 gag tgg gtg gcc ttt ata tgg tat gat gga agt gat aaa tac tat gca 240 Glu Trp Val Ala Phe Ile Trp Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala 65 70 75 80 gac tct gtg aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac 288 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 85 90 95 acg ctg tat ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg 336 Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 tat tac tgt gcg aga gat ggg gat agc agt gac tgg tac ggg gac tac 384 Tyr Tyr Cys Ala Arg Asp Gly Asp Ser Ser Asp Trp Tyr Gly Asp Tyr 115 120 125 tac ttc ggt atg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc 432 Tyr Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 130 135 140 tca 435 Ser 145 < 210 > 45 < 211 > 145 < 212 > PRT < 213 > Homo sapiens < 400 > 45 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 20 25 30 Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 35 40 45 Ser Thr Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Val Ala Phe Ile Trp Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala 65 70 75 80 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 85 90 95 Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Arg Asp Gly Asp Ser Ser Asp Trp Tyr Gly Asp Tyr 115 120 125 Tyr Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 130 135 140 Ser 145 < 210 > 46 < 211 > 15 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 15 ) < 400 > 46 acc tat ggc atg cac 15 Thr Tyr Gly Met His 1 5 < 210 > 47 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 47 Thr Tyr Gly Met His 1 5 < 210 > 48 < 211 > 51 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 51 ) < 400 > 48 ttt ata tgg tat gat gga agt gat aaa tac tat gca gac tct gtg aag 48 Phe Ile Trp Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 ggc 51 Gly < 210 > 49 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 49 Phe Ile Trp Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 50 < 211 > 51 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 51 ) < 400 > 50 gat ggg gat agc agt gac tgg tac ggg gac tac tac ttc ggt atg gac 48 Asp Gly Asp Ser Ser Asp Trp Tyr Gly Asp Tyr Tyr Phe Gly Met Asp 1 5 10 15 gtc 51 Val < 210 > 51 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 51 Asp Gly Asp Ser Ser Asp Trp Tyr Gly Asp Tyr Tyr Phe Gly Met Asp 1 5 10 15 Val < 210 > 52 < 211 > 378 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 378 ) < 400 > 52 atg gaa acc cca gcg cag ctt ctc ttc ctc ctg cta ctc tgg ctc cca 48 Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 gat acc acc gga gaa att gtg ttg acg cag tct cca ggc acc ctg tct 96 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 20 25 30 ttg tct cca ggg gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt 144 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 35 40 45 gtt agc agc agc tac tta gcc tgg tac cag cag aaa cct ggc cag gct 192 Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 50 55 60 ccc agg ctc ctc atc tat ggt gca tcc agc agg gcc act ggc atc cca 240 Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 65 70 75 80 gac agg ttc agt ggc agt ggg tct ggg aca gac ttc act ctc acc atc 288 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 85 90 95 agc aga ctg gag cct gaa gat ttt gca gtg tat tac tgt cag cag tat 336 Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 100 105 110 ggt agc tgg acg ttc ggc caa ggg acc aag gtg gaa atc aaa 378 Gly Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 53 < 211 > 126 < 212 > PRT < 213 > Homo sapiens < 400 > 53 Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 20 25 30 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 35 40 45 Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 50 55 60 Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 85 90 95 Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 100 105 110 Gly Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 54 < 211 > 36 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 36 ) < 400 > 54 agg gcc agt cag agt gtt agc agc agc tac tta gcc 36 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 55 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 400 > 55 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 56 < 211 > 21 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 21 ) < 400 > 56 ggt gca tcc agc agg gcc act 21 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 57 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 57 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 58 < 211 > 21 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 21 ) < 400 > 58 cag cag tat ggt agc tgg acg 21 Gln Gln Tyr Gly Ser Trp Thr 1 5 < 210 > 59 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 59 Gln Gln Tyr Gly Ser Trp Thr 1 5 < 210 > 60 < 211 > 417 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 417 ) < 400 > 60 atg gaa ctg ggg ctc cgc tgg gtt ttc ctt gtt gct att tta gaa ggt 48 Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly 1 5 10 15 gtc cag tgt gag gtg cag ctg gtg gag tct ggg gga ggc ctg gtc aag 96 Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 20 25 30 cct ggg ggg tcc ctg aga ctc tcc tgt gca gcc tct gga ttc atc ttc 144 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe 35 40 45 agt agc tat agc atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg 192 Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 gag tgg gtc tca tcc att act agt ggt agt tat tac ata cac tac gca 240 Glu Trp Val Ser Ser Ile Thr Ser Gly Ser Tyr Tyr Ile His Tyr Ala 65 70 75 80 gac tca gtg aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac 288 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 85 90 95 tca ctg tat ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg 336 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 tat tac tgt gtg aga gag aga gga tgg ggc tac tac ggt atg gac gtc 384 Tyr Tyr Cys Val Arg Glu Arg Gly Trp Gly Tyr Tyr Gly Met Asp Val 115 120 125 tgg ggc caa ggg acc acg gtc acc gtc tcc tca 417 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 61 < 211 > 139 < 212 > PRT < 213 > Homo sapiens < 400 > 61 Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly 1 5 10 15 Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 20 25 30 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe 35 40 45 Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Val Ser Ser Ile Thr Ser Gly Ser Tyr Tyr Ile His Tyr Ala 65 70 75 80 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 85 90 95 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Val Arg Glu Arg Gly Trp Gly Tyr Tyr Gly Met Asp Val 115 120 125 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 62 < 211 > 15 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 15 ) < 400 > 62 agc tat agc atg aac 15 Ser Tyr Ser Met Asn 1 5 < 210 > 63 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 63 Ser Tyr Ser Met Asn 1 5 < 210 > 64 < 211 > 51 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 51 ) < 400 > 64 tcc att act agt ggt agt tat tac ata cac tac gca gac tca gtg aag 48 Ser Ile Thr Ser Gly Ser Tyr Tyr Ile His Tyr Ala Asp Ser Val Lys 1 5 10 15 ggc 51 Gly < 210 > 65 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 65 Ser Ile Thr Ser Gly Ser Tyr Tyr Ile His Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 66 < 211 > 33 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 33 ) < 400 > 66 gag aga gga tgg ggc tac tac ggt atg gac gtc 33 Glu Arg Gly Trp Gly Tyr Tyr Gly Met Asp Val 1 5 10 < 210 > 67 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 67 Glu Arg Gly Trp Gly Tyr Tyr Gly Met Asp Val 1 5 10 < 210 > 68 < 211 > 387 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 387 ) < 400 > 68 atg gac atg agg gtc ccc gct cag ctc ctg ggg ctt ctg ctg ctc tgg 48 Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 1 5 10 15 ctc cca ggt gcc aga tgt gcc atc cag ttg acc cag tct cca tcc tcc 96 Leu Pro Gly Ala Arg Cys Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser 20 25 30 ctg tct gca tct gtt gga gac aga gtc acc atc act tgc cgg gca agt 144 Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 35 40 45 cag gac att gac agt gct tta gcc tgg tat cag cag aaa cca ggg aaa 192 Gln Asp Ile Asp Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 50 55 60 gct cct aag atc ctg atc cat gat gcc tcc agt ttg gaa agt ggg gtc 240 Ala Pro Lys Ile Leu Ile His Asp Ala Ser Ser Leu Glu Ser Gly Val 65 70 75 80 cca tca agg ttc agc ggc agt gga tct ggg aca gat ttc act ctc acc 288 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 85 90 95 atc agc agc ctg cag cct gaa gat ttt gca act tat tac tgt caa cag 336 Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 100 105 110 ttt aat agt tac ccg tac act ttt ggc cag ggg acc aag ctg gag atc 384 Phe Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 115 120 125 aaa 387 Lys < 210 > 69 < 211 > 129 < 212 > PRT < 213 > Homo sapiens < 400 > 69 Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 1 5 10 15 Leu Pro Gly Ala Arg Cys Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser 20 25 30 Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 35 40 45 Gln Asp Ile Asp Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 50 55 60 Ala Pro Lys Ile Leu Ile His Asp Ala Ser Ser Leu Glu Ser Gly Val 65 70 75 80 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 85 90 95 Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 100 105 110 Phe Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 115 120 125 Lys < 210 > 70 < 211 > 33 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 33 ) < 400 > 70 cgg gca agt cag gac att gac agt gct tta gcc 33 Arg Ala Ser Gln Asp Ile Asp Ser Ala Leu Ala 1 5 10 < 210 > 71 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 71 Arg Ala Ser Gln Asp Ile Asp Ser Ala Leu Ala 1 5 10 < 210 > 72 < 211 > 21 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 21 ) < 400 > 72 gat gcc tcc agt ttg gaa agt 21 Asp Ala Ser Ser Leu Glu Ser 1 5 < 210 > 73 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 73 Asp Ala Ser Ser Leu Glu Ser 1 5 < 210 > 74 < 211 > 27 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 27 ) < 400 > 74 caa cag ttt aat agt tac ccg tac act 27 Gln Gln Phe Asn Ser Tyr Pro Tyr Thr 1 5 < 210 > 75 < 211 > 9 < 212 > PRT < 213 > Homo sapiens < 400 > 75 Gln Gln Phe Asn Ser Tyr Pro Tyr Thr 1 5 < 210 > 76 < 211 > 408 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 408 ) < 400 > 76 atg aaa cat ctg tgg ttc ttc ctt ctc ctg gtg gca gct ccc aga tgg 48 Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 1 5 10 15 gtc ctg tcc cag gta cag ctg cag gag tcg ggc cca gga ctg gtg aag 96 Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 20 25 30 cct tcg gag acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc 144 Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 35 40 45 agt agt gac ttc tgg ggc tgg atc cgg cag ccc cca ggg aag gga ctg 192 Ser Ser Asp Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 50 55 60 gag tgg att gga tat atc tct tcc cgt ggg agc acc aac tac aac ccc 240 Glu Trp Ile Gly Tyr Ile Ser Ser Arg Gly Ser Thr Asn Tyr Asn Pro 65 70 75 80 tcc ctc aag agg cga gtc acc ata tca gtc gac acg tcc agg aac cag 288 Ser Leu Lys Arg Arg Val Thr Ile Ser Val Asp Thr Ser Arg Asn Gln 85 90 95 ttc tcc ctg aag ctg agc tct gtg acc gct gcg gac acg gcc gtg tat 336 Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 100 105 110 tac tgt gcg aga tct gcg gga gta acg gat ttt gac ttc tgg ggc cag 384 Tyr Cys Ala Arg Ser Ala Gly Val Thr Asp Phe Asp Phe Trp Gly Gln 115 120 125 gga acc ctg gtc acc gtc tcc tca 408 Gly Thr Leu Val Thr Val Ser Ser 130 135 < 210 > 77 < 211 > 136 < 212 > PRT < 213 > Homo sapiens < 400 > 77 Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 1 5 10 15 Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 20 25 30 Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 35 40 45 Ser Ser Asp Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Gly Tyr Ile Ser Ser Arg Gly Ser Thr Asn Tyr Asn Pro 65 70 75 80 Ser Leu Lys Arg Arg Val Thr Ile Ser Val Asp Thr Ser Arg Asn Gln 85 90 95 Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 100 105 110 Tyr Cys Ala Arg Ser Ala Gly Val Thr Asp Phe Asp Phe Trp Gly Gln 115 120 125 Gly Thr Leu Val Thr Val Ser Ser 130 135 < 210 > 78 < 211 > 15 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 15 ) < 400 > 78 agt gac ttc tgg ggc 15 Ser Asp Phe Trp Gly 1 5 < 210 > 79 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 79 Ser Asp Phe Trp Gly 1 5 < 210 > 80 < 211 > 49 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 49 ) < 400 > 80 tat atc tct tcc cgt ggg agc acc aac tac aac ccc tcc ctc aag agg 48 Tyr Ile Ser Ser Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Arg 1 5 10 15 c 49 < 210 > 81 < 211 > 16 < 212 > PRT < 213 > Homo sapiens < 400 > 81 Tyr Ile Ser Ser Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Arg 1 5 10 15 < 210 > 82 < 211 > 27 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 27 ) < 400 > 82 tct gcg gga gta acg gat ttt gac ttc 27 Ser Ala Gly Val Thr Asp Phe Asp Phe 1 5 < 210 > 83 < 211 > 9 < 212 > PRT < 213 > Homo sapiens < 400 > 83 Ser Ala Gly Val Thr Asp Phe Asp Phe 1 5 < 210 > 84 < 211 > 387 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 387 ) < 400 > 84 atg gac atg atg gtc ccc gct cag ctc ctg ggg ctc ctg ctg ctc tgg 48 Met Asp Met Met Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 1 5 10 15 ttc cca ggt tcc aga tgc gac atc cag atg acc cag tct cca tct tcc 96 Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 20 25 30 gtg tct gca tct gta gga gac aga gtc acc atc act tgt cgg gcg agt 144 Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 35 40 45 cag ggt att agc agc tgg tta gcc tgg tat cag cat aaa cca ggg aaa 192 Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln His Lys Pro Gly Lys 50 55 60 gcc cct aag ctc ctg atc tat gtt gca tcc agt ttg caa agt ggg gtc 240 Ala Pro Lys Leu Leu Ile Tyr Val Ala Ser Ser Leu Gln Ser Gly Val 65 70 75 80 cca tca agg ttc agc ggc agt gga tct ggg aca gat ttc act ctc acc 288 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 85 90 95 atc agc agc ctg cag cct gaa gat ttt gca act tac tat tgt caa cag 336 Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 100 105 110 gct aat agt ttc cct ctc act ttc ggc gga ggg acc aag gtg gag atc 384 Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 115 120 125 aaa 387 Lys < 210 > 85 < 211 > 129 < 212 > PRT < 213 > Homo sapiens < 400 > 85 Met Asp Met Met Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 1 5 10 15 Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 20 25 30 Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 35 40 45 Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln His Lys Pro Gly Lys 50 55 60 Ala Pro Lys Leu Leu Ile Tyr Val Ala Ser Ser Leu Gln Ser Gly Val 65 70 75 80 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 85 90 95 Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 100 105 110 Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 115 120 125 Lys < 210 > 86 < 211 > 33 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 33 ) < 400 > 86 cgg gcg agt cag ggt att agc agc tgg tta gcc 33 Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 1 5 10 < 210 > 87 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 87 Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 1 5 10 < 210 > 88 < 211 > 21 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 21 ) < 400 > 88 gtt gca tcc agt ttg caa agt 21 Val Ala Ser Ser Leu Gln Ser 1 5 < 210 > 89 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 89 Val Ala Ser Ser Leu Gln Ser 1 5 < 210 > 90 < 211 > 27 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > CDS < 222 > ( 1 ) . ..( 27 ) < 400 > 90 caa cag gct aat agt ttc cct ctc act 27 Gln Gln Ala Asn Ser Phe Pro Leu Thr 1 5 < 210 > 91 < 211 > 9 < 212 > PRT < 213 > Homo sapiens < 400 > 91 Gln Gln Ala Asn Ser Phe Pro Leu Thr 1 5 < 210 > 92 < 211 > 153 < 212 > PRT < 213 > Homo sapiens < 400 > 92 Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 1 5 10 15 Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 20 25 30 Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 35 40 45 Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 50 55 60 Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 65 70 75 80 Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 85 90 95 Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 100 105 110 Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 115 120 125 Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 130 135 140 Cys Gln Ser Ile Ile Ser Thr Leu Thr 145 150 < 210 > 93 < 211 > 153 < 212 > PRT < 213 > Homo sapiens < 400 > 93 Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 1 5 10 15 Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 20 25 30 Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 35 40 45 Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 50 55 60 Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 65 70 75 80 Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 85 90 95 Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 100 105 110 Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 115 120 125 Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 130 135 140 Arg Glu Lys Tyr Ser Lys Cys Ser Ser 145 150 < 210 > 94 < 211 > 162 < 212 > PRT < 213 > Homo sapiens < 400 > 94 Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 1 5 10 15 Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 20 25 30 Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 35 40 45 Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 50 55 60 Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 65 70 75 80 Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 85 90 95 Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 100 105 110 Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 115 120 125 Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 130 135 140 Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 145 150 155 160 Thr Ser < 210 > 95 < 211 > 177 < 212 > PRT < 213 > Homo sapiens < 400 > 95 Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 1 5 10 15 Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 20 25 30 Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 35 40 45 Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 50 55 60 Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 65 70 75 80 Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 85 90 95 Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 100 105 110 Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 115 120 125 Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 130 135 140 Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 145 150 155 160 Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 165 170 175 His < 210 > 96 < 211 > 144 < 212 > PRT < 213 > Homo sapiens < 400 > 96 Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 1 5 10 15 Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 20 25 30 Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 35 40 45 Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 50 55 60 Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 65 70 75 80 Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 85 90 95 Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 100 105 110 Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 115 120 125 Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 130 135 140 < 210 > 97 < 211 > 146 < 212 > PRT < 213 > Rattus norvegicus < 400 > 97 Met Glu Arg Thr Leu Val Cys Leu Ile Leu Ile Phe Leu Gly Thr Val 1 5 10 15 Ala His Lys Ser Ser Pro Gln Arg Pro Asp His Leu Leu Ile Arg Leu 20 25 30 Arg His Leu Met Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp 35 40 45 Leu Asp Pro Glu Leu Leu Thr Ala Pro Gln Asp Val Lys Gly Gln Cys 50 55 60 Glu His Glu Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser 65 70 75 80 Asn Thr Gly Asn Asn Lys Thr Phe Ile Asn Asp Leu Leu Ala Gln Leu 85 90 95 Arg Arg Arg Leu Pro Ala Lys Arg Thr Gly Asn Lys Gln Arg His Met 100 105 110 Ala Lys Cys Pro Ser Cys Asp Leu Tyr Glu Lys Lys Thr Pro Lys Glu 115 120 125 Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His 130 135 140 Leu Ser 145