SEQUENCE LISTING < 110 > ADIMAB , LLC . < 120 > MULTISPECIFIC BINDING PROTEINS TARGETING CAIX , ANO 1 , MESOTHELIN , TROP 2 , CEA , OR CLAUDIN - 18 . 2 < 130 > DFY - 012 WO < 140 > < 141 > < 150 > 62 / 473 , 659 < 151 > 2017 - 03 - 20 < 150 > 62 / 473 , 652 < 151 > 2017 - 03 - 20 < 150 > 62 / 467 , 557 < 151 > 2017 - 03 - 06 < 150 > 62 / 464 , 347 < 151 > 2017 - 02 - 27 < 150 > 62 / 464 , 344 < 151 > 2017 - 02 - 27 < 150 > 62 / 464 , 341 < 151 > 2017 - 02 - 27 < 160 > 236 < 170 > PatentIn version 3 . 5 < 210 > 1 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 1 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 2 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 2 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 3 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 3 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 4 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 4 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Ile Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 5 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 5 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 6 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 6 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Phe Tyr Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 7 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 7 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 8 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 8 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Tyr Tyr Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 9 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 9 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 10 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 10 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 11 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 11 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Gly Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 12 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 12 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 < 210 > 13 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 13 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 14 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 14 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Phe Pro Ile 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 15 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 15 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 16 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 16 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 17 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 17 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 18 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 18 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Phe Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 19 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 19 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 20 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 20 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Tyr Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 21 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 21 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 22 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 22 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 23 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 23 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 24 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 24 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Phe Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 25 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 25 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 26 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 26 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Ser Phe Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 27 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 27 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 28 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 28 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Phe Ser Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 29 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 29 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 30 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 30 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Ser Tyr Ser Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 31 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 31 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 32 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 32 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Phe Ile Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 33 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 33 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 34 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 34 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Ser Tyr Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 35 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 35 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 36 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 36 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Phe Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 37 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 37 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 38 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 38 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Leu Tyr Ser Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 39 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 39 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 40 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 40 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Thr Phe Ile Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 41 < 211 > 125 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 41 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Ser Ser Ile Arg His Ala Tyr Tyr Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 < 210 > 42 < 211 > 113 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 42 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Ser Thr Pro Ile Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 100 105 110 Lys < 210 > 43 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 43 Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Asp Arg Phe His Pro Tyr Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 44 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 44 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Thr Trp Pro Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 45 < 211 > 126 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 45 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg Gly Arg Lys Ala Ser Gly Ser Phe Tyr Tyr Tyr Tyr Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 < 210 > 46 < 211 > 113 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 46 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Glu Ser Ser Gln Ser Leu Leu Asn Ser 20 25 30 Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Pro Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 85 90 95 Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 100 105 110 Lys < 210 > 47 < 211 > 121 < 212 > PRT < 213 > Homo sapiens < 400 > 47 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Arg Gly Leu Gly Asp Gly Thr Tyr Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 < 210 > 48 < 211 > 110 < 212 > PRT < 213 > Homo sapiens < 400 > 48 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Phe Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 49 < 211 > 115 < 212 > PRT < 213 > Homo sapiens < 400 > 49 Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Asp Asp Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly His Ile Ser Tyr Ser Gly Ser Ala Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Asn Trp Asp Asp Ala Phe Asn Ile Trp Gly Gln Gly Thr Met Val Thr 100 105 110 Val Ser Ser 115 < 210 > 50 < 211 > 108 < 212 > PRT < 213 > Homo sapiens < 400 > 50 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 51 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 51 Gly Ser Phe Ser Gly Tyr Tyr Trp Ser 1 5 < 210 > 52 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 52 Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 53 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 53 Ala Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro 1 5 10 < 210 > 54 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 54 Gly Thr Phe Ser Ser Tyr Ala Ile Ser 1 5 < 210 > 55 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 55 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly < 210 > 56 < 211 > 18 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 56 Ala Arg Gly Asp Ser Ser Ile Arg His Ala Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val < 210 > 57 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 57 Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 1 5 10 15 Ala < 210 > 58 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 58 Trp Ala Ser Thr Arg Glu Ser 1 5 < 210 > 59 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 59 Gln Gln Tyr Tyr Ser Thr Pro Ile Thr 1 5 < 210 > 60 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 60 Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly 1 5 10 < 210 > 61 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 61 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 62 < 211 > 13 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 62 Ala Arg Gly Ser Asp Arg Phe His Pro Tyr Phe Asp Tyr 1 5 10 < 210 > 63 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 63 Arg Ala Ser Gln Ser Val Ser Arg Tyr Leu Ala 1 5 10 < 210 > 64 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 64 Asp Ala Ser Asn Arg Ala Thr 1 5 < 210 > 65 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 65 Gln Gln Phe Asp Thr Trp Pro Pro Thr 1 5 < 210 > 66 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 66 Gly Thr Phe Ser Ser Tyr Ala Ile Ser 1 5 < 210 > 67 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 67 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly < 210 > 68 < 211 > 19 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 68 Ala Arg Arg Gly Arg Lys Ala Ser Gly Ser Phe Tyr Tyr Tyr Tyr Gly 1 5 10 15 Met Asp Val < 210 > 69 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 69 Glu Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 1 5 10 15 Thr < 210 > 70 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 70 Trp Ala Ser Thr Arg Glu Ser 1 5 < 210 > 71 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 71 Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 1 5 < 210 > 72 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 72 Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Leu Gly Gly 1 5 10 15 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Tyr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Leu Val 35 40 45 Ala Ala Ile Asn Ser Asp Gly Gly Ile Thr Tyr Tyr Leu Asp Thr Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Phe Tyr Cys 85 90 95 Ala Arg His Arg Ser Gly Tyr Phe Ser Met Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Ser Val Thr Val Ser Ser 115 < 210 > 73 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 73 Asp Ile Val Met Thr Gln Ser Gln Arg Phe Met Ser Thr Thr Val Gly 1 5 10 15 Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Val Ser Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 65 70 75 80 Glu Asp Leu Ala Asp Phe Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Trp 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 < 210 > 74 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 74 Gly Phe Thr Phe Ser Asn Tyr 1 5 < 210 > 75 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 75 Asn Ser Asp Gly Gly Ile 1 5 < 210 > 76 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 76 His Arg Ser Gly Tyr Phe Ser Met Asp Tyr 1 5 10 < 210 > 77 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 77 Gln Asn Val Val Ser Ala Val Ala 1 5 < 210 > 78 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 78 Ser Ala Ser Asn Arg Tyr Thr 1 5 < 210 > 79 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 79 Gln Gln Tyr Ser Asn Tyr Pro Trp Thr 1 5 < 210 > 80 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 80 Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Ser Leu Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Ser Pro Gly Thr Phe Met His Gly Asp His Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 81 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 81 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Gly Arg Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 82 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 82 Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser 1 5 10 < 210 > 83 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 83 Gly Ile Ser Ser Leu Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 84 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 84 Thr Gly Ser Pro Gly Thr Phe Met His Gly Asp His 1 5 10 < 210 > 85 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 85 Arg Ala Ser Gln Asp Ile Asn Asn Tyr Leu Ser 1 5 10 < 210 > 86 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 86 Tyr Gly Ala Ser Asn Leu Gln Ser 1 5 < 210 > 87 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 87 Gln Gln Tyr Tyr Gly Arg Pro Thr 1 5 < 210 > 88 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 88 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Leu Val 35 40 45 Ser Ala Ile Asn Ser Asp Gly Gly Ile Thr Tyr Tyr Leu Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg His Arg Ser Gly Tyr Phe Ser Met Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 89 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 89 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Val Ser Ala 20 25 30 Val Ala Trp Tyr Leu Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Trp 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 < 210 > 90 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 90 Gly Phe Thr Phe Ser Asn Tyr 1 5 < 210 > 91 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 91 Asn Ser Asp Gly Gly Ile 1 5 < 210 > 92 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 92 His Arg Ser Gly Tyr Phe Ser Met Asp Tyr 1 5 10 < 210 > 93 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 93 Gln Asn Val Val Ser Ala Val Ala 1 5 < 210 > 94 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 94 Ser Ala Ser Asn Arg Tyr Thr 1 5 < 210 > 95 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 95 Gln Gln Tyr Ser Asn Tyr Pro Trp Thr 1 5 < 210 > 96 < 211 > 459 < 212 > PRT < 213 > Unknown < 220 > < 223 > Description of Unknown : CAIX polypeptide < 400 > 96 Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 1 5 10 15 Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 20 25 30 Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 35 40 45 Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 50 55 60 Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 65 70 75 80 Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 85 90 95 Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 100 105 110 Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 115 120 125 Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 130 135 140 Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 145 150 155 160 Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 165 170 175 Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 180 185 190 Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 195 200 205 Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 210 215 220 Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 225 230 235 240 Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 245 250 255 Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 260 265 270 Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 275 280 285 Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 290 295 300 Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 305 310 315 320 Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 325 330 335 Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 340 345 350 Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 355 360 365 Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 370 375 380 Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 385 390 395 400 Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 405 410 415 Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 420 425 430 Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 435 440 445 Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 450 455 < 210 > 97 < 211 > 123 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 97 Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Asp Trp Met 35 40 45 Gly Val Ile Trp Gly Asn Gly Lys Thr Gln Tyr Asn Ser Gly Leu Thr 50 55 60 Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 65 70 75 80 Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 85 90 95 Arg Ser Gly Tyr Tyr Tyr Asp Gly Ser Tyr Tyr Ser Leu Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 115 120 < 210 > 98 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 98 Asp Val Val Leu Thr Gln Thr Pro Pro Thr Leu Ser Ala Thr Ile Gly 1 5 10 15 Gln Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Pro 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Val Ser Arg Leu Glu Ser Gly Val Pro 50 55 60 Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Ser 85 90 95 Thr His Ala Pro Ala Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 100 105 110 < 210 > 99 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 99 Asn Tyr Asp Met His 1 5 < 210 > 100 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 100 Val Ile Trp Gly Asn Gly Lys Thr Gln Tyr Asn Ser Gly Leu Thr Ser 1 5 10 15 < 210 > 101 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 101 Ser Gly Tyr Tyr Tyr Asp Gly Ser Tyr Tyr Ser Leu Phe Asp Tyr 1 5 10 15 < 210 > 102 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 102 Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Asn 1 5 10 15 < 210 > 103 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 103 Leu Val Ser Arg Leu Glu Ser 1 5 < 210 > 104 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 104 Val Gln Ser Thr His Ala Pro Ala 1 5 < 210 > 105 < 211 > 986 < 212 > PRT < 213 > Unknown < 220 > < 223 > Description of Unknown : ANO 1 polypeptide < 400 > 105 Met Arg Val Asn Glu Lys Tyr Ser Thr Leu Pro Ala Glu Asp Arg Ser 1 5 10 15 Val His Ile Ile Asn Ile Cys Ala Ile Glu Asp Ile Gly Tyr Leu Pro 20 25 30 Ser Glu Gly Thr Leu Leu Asn Ser Leu Ser Val Asp Pro Asp Ala Glu 35 40 45 Cys Lys Tyr Gly Leu Tyr Phe Arg Asp Gly Arg Arg Lys Val Asp Tyr 50 55 60 Ile Leu Val Tyr His His Lys Arg Pro Ser Gly Asn Arg Thr Leu Val 65 70 75 80 Arg Arg Val Gln His Ser Asp Thr Pro Ser Gly Ala Arg Ser Val Lys 85 90 95 Gln Asp His Pro Leu Pro Gly Lys Gly Ala Ser Leu Asp Ala Gly Ser 100 105 110 Gly Glu Pro Pro Met Asp Tyr His Glu Asp Asp Lys Arg Phe Arg Arg 115 120 125 Glu Glu Tyr Glu Gly Asn Leu Leu Glu Ala Gly Leu Glu Leu Glu Arg 130 135 140 Asp Glu Asp Thr Lys Ile His Gly Val Gly Phe Val Lys Ile His Ala 145 150 155 160 Pro Trp Asn Val Leu Cys Arg Glu Ala Glu Phe Leu Lys Leu Lys Met 165 170 175 Pro Thr Lys Lys Met Tyr His Ile Asn Glu Thr Arg Gly Leu Leu Lys 180 185 190 Lys Ile Asn Ser Val Leu Gln Lys Ile Thr Asp Pro Ile Gln Pro Lys 195 200 205 Val Ala Glu His Arg Pro Gln Thr Met Lys Arg Leu Ser Tyr Pro Phe 210 215 220 Ser Arg Glu Lys Gln His Leu Phe Asp Leu Ser Asp Lys Asp Ser Phe 225 230 235 240 Phe Asp Ser Lys Thr Arg Ser Thr Ile Val Tyr Glu Ile Leu Lys Arg 245 250 255 Thr Thr Cys Thr Lys Ala Lys Tyr Ser Met Gly Ile Thr Ser Leu Leu 260 265 270 Ala Asn Gly Val Tyr Ala Ala Ala Tyr Pro Leu His Asp Gly Asp Tyr 275 280 285 Asn Gly Glu Asn Val Glu Phe Asn Asp Arg Lys Leu Leu Tyr Glu Glu 290 295 300 Trp Ala Arg Tyr Gly Val Phe Tyr Lys Tyr Gln Pro Ile Asp Leu Val 305 310 315 320 Arg Lys Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly 325 330 335 Val Tyr Thr Gln Met Leu Ile Pro Ala Ser Ile Val Gly Ile Ile Val 340 345 350 Phe Leu Tyr Gly Cys Ala Thr Met Asp Glu Asn Ile Pro Ser Met Glu 355 360 365 Met Cys Asp Gln Arg His Asn Ile Thr Met Cys Pro Leu Cys Asp Lys 370 375 380 Thr Cys Ser Tyr Trp Lys Met Ser Ser Ala Cys Ala Thr Ala Arg Ala 385 390 395 400 Ser His Leu Phe Asp Asn Pro Ala Thr Val Phe Phe Ser Val Phe Met 405 410 415 Ala Leu Trp Ala Ala Thr Phe Met Glu His Trp Lys Arg Lys Gln Met 420 425 430 Arg Leu Asn Tyr Arg Trp Asp Leu Thr Gly Phe Glu Glu Glu Glu Glu 435 440 445 Ala Val Lys Asp His Pro Arg Ala Glu Tyr Glu Ala Arg Val Leu Glu 450 455 460 Lys Ser Leu Lys Lys Glu Ser Arg Asn Lys Glu Lys Arg Arg His Ile 465 470 475 480 Pro Glu Glu Ser Thr Asn Lys Trp Lys Gln Arg Val Lys Thr Ala Met 485 490 495 Ala Gly Val Lys Leu Thr Asp Lys Val Lys Leu Thr Trp Arg Asp Arg 500 505 510 Phe Pro Ala Tyr Leu Thr Asn Leu Val Ser Ile Ile Phe Met Ile Ala 515 520 525 Val Thr Phe Ala Ile Val Leu Gly Val Ile Ile Tyr Arg Ile Ser Met 530 535 540 Ala Ala Ala Leu Ala Met Asn Ser Ser Pro Ser Val Arg Ser Asn Ile 545 550 555 560 Arg Val Thr Val Thr Ala Thr Ala Val Ile Ile Asn Leu Val Val Ile 565 570 575 Ile Leu Leu Asp Glu Val Tyr Gly Cys Ile Ala Arg Trp Leu Thr Lys 580 585 590 Ile Glu Val Pro Lys Thr Glu Lys Ser Phe Glu Glu Arg Leu Ile Phe 595 600 605 Lys Ala Phe Leu Leu Lys Phe Val Asn Ser Tyr Thr Pro Ile Phe Tyr 610 615 620 Val Ala Phe Phe Lys Gly Arg Phe Val Gly Arg Pro Gly Asp Tyr Val 625 630 635 640 Tyr Ile Phe Arg Ser Phe Arg Met Glu Glu Cys Ala Pro Gly Gly Cys 645 650 655 Leu Met Glu Leu Cys Ile Gln Leu Ser Ile Ile Met Leu Gly Lys Gln 660 665 670 Leu Ile Gln Asn Asn Leu Phe Glu Ile Gly Ile Pro Lys Met Lys Lys 675 680 685 Leu Ile Arg Tyr Leu Lys Leu Lys Gln Gln Ser Pro Pro Asp His Glu 690 695 700 Glu Cys Val Lys Arg Lys Gln Arg Tyr Glu Val Asp Tyr Asn Leu Glu 705 710 715 720 Pro Phe Ala Gly Leu Thr Pro Glu Tyr Met Glu Met Ile Ile Gln Phe 725 730 735 Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Phe 740 745 750 Ala Leu Leu Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Lys Lys Phe 755 760 765 Val Thr Glu Leu Arg Arg Pro Val Ala Val Arg Ala Lys Asp Ile Gly 770 775 780 Ile Trp Tyr Asn Ile Leu Arg Gly Ile Gly Lys Leu Ala Val Ile Ile 785 790 795 800 Asn Ala Phe Val Ile Ser Phe Thr Ser Asp Phe Ile Pro Arg Leu Val 805 810 815 Tyr Leu Tyr Met Tyr Ser Lys Asn Gly Thr Met His Gly Phe Val Asn 820 825 830 His Thr Leu Ser Ser Phe Asn Val Ser Asp Phe Gln Asn Gly Thr Ala 835 840 845 Pro Asn Asp Pro Leu Asp Leu Gly Tyr Glu Val Gln Ile Cys Arg Tyr 850 855 860 Lys Asp Tyr Arg Glu Pro Pro Trp Ser Glu Asn Lys Tyr Asp Ile Ser 865 870 875 880 Lys Asp Phe Trp Ala Val Leu Ala Ala Arg Leu Ala Phe Val Ile Val 885 890 895 Phe Gln Asn Leu Val Met Phe Met Ser Asp Phe Val Asp Trp Val Ile 900 905 910 Pro Asp Ile Pro Lys Asp Ile Ser Gln Gln Ile His Lys Glu Lys Val 915 920 925 Leu Met Val Glu Leu Phe Met Arg Glu Glu Gln Asp Lys Gln Gln Leu 930 935 940 Leu Glu Thr Trp Met Glu Lys Glu Arg Gln Lys Asp Glu Pro Pro Cys 945 950 955 960 Asn His His Asn Thr Lys Ala Cys Pro Asp Ser Leu Gly Ser Pro Ala 965 970 975 Pro Ser His Ala Tyr His Gly Gly Val Leu 980 985 < 210 > 106 < 211 > 120 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 106 Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 20 25 30 Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 35 40 45 Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 50 55 60 Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 100 105 110 Thr Pro Val Thr Val Ser Ser Ala 115 120 < 210 > 107 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 107 Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 65 70 75 80 Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 85 90 95 Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Arg 100 105 < 210 > 108 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 108 Gly Tyr Ser Phe Thr Gly Tyr 1 5 < 210 > 109 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 109 Thr Pro Tyr Asn Gly Ala 1 5 < 210 > 110 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 110 Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr 1 5 10 < 210 > 111 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 111 Ser Ser Val Ser Tyr Met His 1 5 < 210 > 112 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 112 Asp Thr Ser Lys Leu Ala Ser 1 5 < 210 > 113 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 113 Gln Gln Trp Ser Lys His Pro Leu Thr 1 5 < 210 > 114 < 211 > 131 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 114 Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Gln Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Lys Gln Ala Gly Ser Glu Lys Thr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Ala Tyr Tyr Tyr Asp Ser Ala Ser Tyr Tyr Pro Tyr 100 105 110 Tyr Tyr Tyr Tyr Ser Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 < 210 > 115 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 115 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Gln 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 < 210 > 116 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 116 Gly Phe Thr Phe Ser Arg Tyr 1 5 < 210 > 117 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 117 Lys Gln Ala Gly Ser Glu 1 5 < 210 > 118 < 211 > 22 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 118 Glu Gly Ala Tyr Tyr Tyr Asp Ser Ala Ser Tyr Tyr Pro Tyr Tyr Tyr 1 5 10 15 Tyr Tyr Ser Met Asp Val 20 < 210 > 119 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 119 Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 < 210 > 120 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 120 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 121 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 121 Gln Gln Tyr Gly Ser Ser Gln Tyr Thr 1 5 < 210 > 122 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 122 Gln Val Glu Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asp Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Gln Leu Tyr Gly Gly Thr Tyr Met Asp Gly Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala 115 120 < 210 > 123 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 123 Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr 20 25 30 Asn Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Gly Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Ile Glu 85 90 95 Ser Ala Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 < 210 > 124 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 124 Gly Tyr Ser Phe Thr Ser Tyr 1 5 < 210 > 125 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 125 Asp Pro Gly Asp Ser Arg 1 5 < 210 > 126 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 126 Gly Gln Leu Tyr Gly Gly Thr Tyr Met Asp Gly 1 5 10 < 210 > 127 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 127 Ser Ser Asp Ile Gly Gly Tyr Asn Ser Val Ser 1 5 10 < 210 > 128 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 128 Gly Val Asn Asn Arg Pro Ser 1 5 < 210 > 129 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 129 Ser Ser Tyr Asp Ile Glu Ser Ala Thr Pro Val 1 5 10 < 210 > 130 < 211 > 630 < 212 > PRT < 213 > Unknown < 220 > < 223 > Description of Unknown : mesothelin polypeptide < 400 > 130 Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 1 5 10 15 Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 20 25 30 Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 35 40 45 Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 50 55 60 Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 65 70 75 80 Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 85 90 95 Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 100 105 110 Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 115 120 125 Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 130 135 140 Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 145 150 155 160 Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 165 170 175 Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 180 185 190 Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 195 200 205 Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 210 215 220 Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 225 230 235 240 Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 245 250 255 Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 260 265 270 Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 275 280 285 Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 290 295 300 Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 305 310 315 320 Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 325 330 335 Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 340 345 350 Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 355 360 365 Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 370 375 380 Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 385 390 395 400 Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 405 410 415 Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 420 425 430 Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 435 440 445 Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 450 455 460 Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 465 470 475 480 Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 485 490 495 Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 500 505 510 Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 515 520 525 Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 530 535 540 Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 545 550 555 560 Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 565 570 575 Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 580 585 590 Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 595 600 605 Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 610 615 620 Leu Ala Ser Thr Leu Ala 625 630 < 210 > 131 < 211 > 246 < 212 > PRT < 213 > Unknown < 220 > < 223 > Description of Unknown : ULBP - 6 polypeptide < 400 > 131 Met Ala Ala Ala Ala Ile Pro Ala Leu Leu Leu Cys Leu Pro Leu Leu 1 5 10 15 Phe Leu Leu Phe Gly Trp Ser Arg Ala Arg Arg Asp Asp Pro His Ser 20 25 30 Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg 35 40 45 Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr 50 55 60 Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys 65 70 75 80 Leu Asn Val Thr Met Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu 85 90 95 Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu Asn 100 105 110 Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 115 120 125 Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Ile Asp 130 135 140 Gly Gln Thr Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr Thr 145 150 155 160 Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys 165 170 175 Asp Val Ala Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Ile Gly 180 185 190 Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser 195 200 205 Ala Gly Ala Pro Leu Ala Met Ser Ser Gly Thr Thr Gln Leu Arg Ala 210 215 220 Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Ile Leu Pro Cys 225 230 235 240 Phe Ile Leu Pro Gly Ile 245 < 210 > 132 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 132 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Gly Tyr Tyr Asp Ser Gly Ala Gly Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 133 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 133 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asp Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Ser Tyr Pro Arg 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 134 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 134 Phe Thr Phe Ser Ser Tyr Ala Met Ser 1 5 < 210 > 135 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 135 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 136 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 136 Ala Lys Asp Gly Gly Tyr Tyr Asp Ser Gly Ala Gly Asp Tyr 1 5 10 < 210 > 137 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 137 Arg Ala Ser Gln Gly Ile Asp Ser Trp Leu Ala 1 5 10 < 210 > 138 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 138 Ala Ala Ser Ser Leu Gln Ser 1 5 < 210 > 139 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 139 Gln Gln Gly Val Ser Tyr Pro Arg Thr 1 5 < 210 > 140 < 211 > 122 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 140 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Ala Pro Met Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 141 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 141 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Ser Phe Pro Arg 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 142 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 142 Phe Thr Phe Ser Ser Tyr Ser Met Asn 1 5 < 210 > 143 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 143 Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 144 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 144 Ala Arg Gly Ala Pro Met Gly Ala Ala Ala Gly Trp Phe Asp Pro 1 5 10 15 < 210 > 145 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 145 Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 1 5 10 < 210 > 146 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 146 Ala Ala Ser Ser Leu Gln Ser 1 5 < 210 > 147 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 147 Gln Gln Gly Val Ser Phe Pro Arg Thr 1 5 < 210 > 148 < 211 > 124 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 148 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Thr Gly Glu Tyr Tyr Asp Thr Asp Asp His Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 < 210 > 149 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 149 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Asp Tyr Trp Pro Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 150 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 150 Tyr Thr Phe Thr Gly Tyr Tyr Met His 1 5 < 210 > 151 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 151 Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly < 210 > 152 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 152 Ala Arg Asp Thr Gly Glu Tyr Tyr Asp Thr Asp Asp His Gly Met Asp 1 5 10 15 Val < 210 > 153 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 153 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 < 210 > 154 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 154 Gly Ala Ser Thr Arg Ala Thr 1 5 < 210 > 155 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 155 Gln Gln Asp Asp Tyr Trp Pro Pro Thr 1 5 < 210 > 156 < 211 > 126 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 156 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Ala Pro Asn Tyr Gly Asp Thr Thr His Asp Tyr Tyr Tyr 100 105 110 Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 115 120 125 < 210 > 157 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 157 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asp Trp Pro Phe 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 158 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 158 Tyr Thr Phe Thr Ser Tyr Tyr Met His 1 5 < 210 > 159 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 159 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly < 210 > 160 < 211 > 19 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 160 Ala Arg Gly Ala Pro Asn Tyr Gly Asp Thr Thr His Asp Tyr Tyr Tyr 1 5 10 15 Met Asp Val < 210 > 161 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 161 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 < 210 > 162 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 162 Gly Ala Ser Thr Arg Ala Thr 1 5 < 210 > 163 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 163 Gln Gln Tyr Asp Asp Trp Pro Phe Thr 1 5 < 210 > 164 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 164 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 165 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 165 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Thr Phe Ile Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 166 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 166 Gly Ser Phe Ser Gly Tyr Tyr Trp Ser 1 5 < 210 > 167 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 167 Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 168 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 168 Ala Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro 1 5 10 < 210 > 169 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 169 Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 1 5 10 < 210 > 170 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 170 Lys Ala Ser Ser Leu Glu Ser 1 5 < 210 > 171 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 171 Gln Gln Tyr Asp Thr Phe Ile Thr 1 5 < 210 > 172 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 172 Ser Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr Asp Asp Phe 50 55 60 Lys Gly Arg Phe Ala Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Ser Ser Leu Lys Ala Asp Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 100 105 110 Gln Gly Ser Leu Val Thr Val Ser Ser 115 120 < 210 > 173 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 173 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys Arg 100 105 < 210 > 174 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 174 Gly Tyr Thr Phe Thr Asn Tyr 1 5 < 210 > 175 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 175 Asn Thr Tyr Thr Gly Glu 1 5 < 210 > 176 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 176 Gly Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val 1 5 10 < 210 > 177 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 177 Gln Asp Val Ser Ile Ala Val Ala 1 5 < 210 > 178 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 178 Ser Ala Ser Tyr Arg Tyr Thr 1 5 < 210 > 179 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 179 Gln Gln His Tyr Ile Thr Pro Leu Thr 1 5 < 210 > 180 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 180 Gln Ile Gln Leu Val Gln Ser Gly His Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Lys Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Met Tyr Phe Cys 85 90 95 Gly Arg Gly Gly Tyr Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 < 210 > 181 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 181 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 182 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 182 Gly Tyr Thr Phe Thr Asn Tyr 1 5 < 210 > 183 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 183 Asn Thr Lys Thr Gly Glu 1 5 < 210 > 184 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 184 Gly Gly Tyr Gly Ser Ser Tyr Trp Tyr Phe Asp Val 1 5 10 < 210 > 185 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 185 Gln Asp Val Ser Ile Ala Val Ala 1 5 < 210 > 186 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 186 Ser Ala Ser Tyr Arg Tyr Thr 1 5 < 210 > 187 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 187 Gln Gln His Tyr Ile Thr Pro Leu Thr 1 5 < 210 > 188 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 188 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 20 25 30 Gly Met Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr His Ser Gly Val Pro Lys Tyr Ala Glu Asp Phe 50 55 60 Lys Gly Arg Val Thr Ile Ser Ala Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 189 < 211 > 109 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 189 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 100 105 < 210 > 190 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 190 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 20 25 30 Gly Met Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr His Ser Gly Val Pro Lys Tyr Ala Glu Asp Phe 50 55 60 Lys Gly Arg Val Thr Ile Ser Leu Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 191 < 211 > 109 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 191 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 100 105 < 210 > 192 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 192 Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 20 25 30 Gly Met Gln Trp Val Gln Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr His Ser Gly Val Pro Lys Tyr Ala Glu Asp Phe 50 55 60 Lys Gly Arg Val Thr Phe Ser Leu Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 193 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 193 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gln Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 < 210 > 194 < 211 > 323 < 212 > PRT < 213 > Unknown < 220 > < 223 > Description of Unknown : TROP 2 polypeptide < 400 > 194 Met Ala Arg Gly Pro Gly Leu Ala Pro Pro Pro Leu Arg Leu Pro Leu 1 5 10 15 Leu Leu Leu Val Leu Ala Ala Val Thr Gly His Thr Ala Ala Gln Asp 20 25 30 Asn Cys Thr Cys Pro Thr Asn Lys Met Thr Val Cys Ser Pro Asp Gly 35 40 45 Pro Gly Gly Arg Cys Gln Cys Arg Ala Leu Gly Ser Gly Met Ala Val 50 55 60 Asp Cys Ser Thr Leu Thr Ser Lys Cys Leu Leu Leu Lys Ala Arg Met 65 70 75 80 Ser Ala Pro Lys Asn Ala Arg Thr Leu Val Arg Pro Ser Glu His Ala 85 90 95 Leu Val Asp Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Pro Glu Gly 100 105 110 Arg Phe Lys Ala Arg Gln Cys Asn Gln Thr Ser Val Cys Trp Cys Val 115 120 125 Asn Ser Val Gly Val Arg Arg Thr Asp Lys Gly Asp Leu Ser Leu Arg 130 135 140 Cys Asp Glu Leu Val Arg Thr His His Ile Leu Ile Asp Leu Arg His 145 150 155 160 Arg Pro Thr Ala Gly Ala Phe Asn His Ser Asp Leu Asp Ala Glu Leu 165 170 175 Arg Arg Leu Phe Arg Glu Arg Tyr Arg Leu His Pro Lys Phe Val Ala 180 185 190 Ala Val His Tyr Glu Gln Pro Thr Ile Gln Ile Glu Leu Arg Gln Asn 195 200 205 Thr Ser Gln Lys Ala Ala Gly Asp Val Asp Ile Gly Asp Ala Ala Tyr 210 215 220 Tyr Phe Glu Arg Asp Ile Lys Gly Glu Ser Leu Phe Gln Gly Arg Gly 225 230 235 240 Gly Leu Asp Leu Arg Val Arg Gly Glu Pro Leu Gln Val Glu Arg Thr 245 250 255 Leu Ile Tyr Tyr Leu Asp Glu Ile Pro Pro Lys Phe Ser Met Lys Arg 260 265 270 Leu Thr Ala Gly Leu Ile Ala Val Ile Val Val Val Val Val Ala Leu 275 280 285 Val Ala Gly Met Ala Val Leu Val Ile Thr Asn Arg Arg Lys Ser Gly 290 295 300 Lys Tyr Lys Lys Val Glu Ile Lys Glu Leu Gly Glu Leu Arg Lys Glu 305 310 315 320 Pro Ser Leu < 210 > 195 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 195 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Thr Thr Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile His Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 50 55 60 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Phe Gly Phe Pro Trp Phe Ala Tyr Trp Gly Gln Gly 100 105 110 Thr Pro Val Thr Val Ser Ser 115 < 210 > 196 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 196 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ser 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Trp Thr Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Leu Tyr Arg Ser 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 197 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 197 Gly Phe Asp Phe Thr Thr Tyr 1 5 < 210 > 198 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 198 His Pro Asp Ser Ser Thr 1 5 < 210 > 199 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 199 Leu Tyr Phe Gly Phe Pro Trp Phe Ala Tyr 1 5 10 < 210 > 200 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 200 Gln Asp Val Gly Thr Ser Val Ala 1 5 < 210 > 201 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 201 Trp Thr Ser Thr Arg His Thr 1 5 < 210 > 202 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 202 Gln Gln Tyr Ser Leu Tyr Arg Ser 1 5 < 210 > 203 < 211 > 122 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 203 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 50 55 60 Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser Ala 115 120 < 210 > 204 < 211 > 109 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 204 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 85 90 95 Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 < 210 > 205 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 205 Gly Tyr Thr Phe Thr Glu Phe 1 5 < 210 > 206 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 206 Asn Thr Lys Thr Gly Glu 1 5 < 210 > 207 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 207 Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr 1 5 10 < 210 > 208 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 208 Ala Ala Val Gly Thr Tyr Val Ala 1 5 < 210 > 209 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 209 Ser Ala Ser Tyr Arg Lys Arg 1 5 < 210 > 210 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 210 His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr 1 5 10 < 210 > 211 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 211 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 1 5 10 15 Ser Ile Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys His Tyr 20 25 30 Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Asn Pro Glu Asn Val Asp Thr Glu Tyr Ala Pro Lys Phe 50 55 60 Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Asn His Tyr Arg Tyr Ala Gly Gly Gly Ala Leu Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Ala 115 120 < 210 > 212 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 212 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Ile 20 25 30 His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Val Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Asn Asn Pro Tyr Ser 85 90 95 Phe Gly Gly Gly Thr Lys Val Val Ile Lys Thr Val 100 105 < 210 > 213 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 213 Gly Phe Asn Ile Lys His Tyr 1 5 < 210 > 214 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 214 Asn Pro Glu Asn Val Asp 1 5 < 210 > 215 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 215 Tyr Arg Tyr Ala Gly Gly Gly Ala Leu Asp Tyr 1 5 10 < 210 > 216 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 216 Ser Ser Val Ser Tyr Ile His 1 5 < 210 > 217 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 217 Asp Thr Ser Lys Leu Ala Ser 1 5 < 210 > 218 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 218 Gln Gln Trp Asn Asn Asn Pro Tyr Ser 1 5 < 210 > 219 < 211 > 702 < 212 > PRT < 213 > Unknown < 220 > < 223 > Description of Unknown : CEA polypeptide < 400 > 219 Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 1 5 10 15 Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 20 25 30 Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 35 40 45 Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 50 55 60 Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 65 70 75 80 Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 85 90 95 Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 100 105 110 Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 115 120 125 Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 130 135 140 Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 145 150 155 160 Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 165 170 175 Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 180 185 190 Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 195 200 205 Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 210 215 220 Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 225 230 235 240 Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 245 250 255 Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 260 265 270 Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 275 280 285 Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 290 295 300 Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 305 310 315 320 Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 325 330 335 Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 340 345 350 Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 355 360 365 Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 370 375 380 Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Lys Leu Ser 385 390 395 400 Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 405 410 415 Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 420 425 430 Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 435 440 445 Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 450 455 460 Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 465 470 475 480 Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 485 490 495 Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 500 505 510 Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 515 520 525 Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 530 535 540 Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 545 550 555 560 Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 565 570 575 Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 580 585 590 Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 595 600 605 Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 610 615 620 Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 625 630 635 640 Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 645 650 655 Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 660 665 670 Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 675 680 685 Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 690 695 700 < 210 > 220 < 211 > 118 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 220 Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 1 5 10 15 Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 35 40 45 Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe 50 55 60 Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Leu Gly Phe Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Ser Val Thr Val Ser Ser 115 < 210 > 221 < 211 > 113 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 221 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 1 5 10 15 Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 20 25 30 Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 85 90 95 Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 100 105 110 Lys < 210 > 222 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 222 Gly Tyr Thr Phe Thr Asn Tyr Gly 1 5 < 210 > 223 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 223 Ile Asn Thr Asn Thr Gly Glu Pro 1 5 < 210 > 224 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 224 Ala Arg Leu Gly Phe Gly Asn Ala Met Asp Tyr 1 5 10 < 210 > 225 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 225 Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 1 5 10 < 210 > 226 < 211 > 3 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 226 Trp Ala Ser 1 < 210 > 227 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 227 Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 1 5 < 210 > 228 < 211 > 118 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 228 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Leu Thr Val Ser Ser 115 < 210 > 229 < 211 > 113 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic polypeptide < 400 > 229 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 1 5 10 15 Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 20 25 30 Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 85 90 95 Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 100 105 110 Lys < 210 > 230 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 230 Gly Tyr Thr Phe Thr Ser Tyr Trp 1 5 < 210 > 231 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 231 Ile Tyr Pro Ser Asp Ser Tyr Thr 1 5 < 210 > 232 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 232 Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr 1 5 10 < 210 > 233 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 233 Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 1 5 10 < 210 > 234 < 211 > 3 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 234 Trp Ala Ser 1 < 210 > 235 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Description of Artificial Sequence : Synthetic peptide < 400 > 235 Gln Asn Asp Tyr Ser Tyr Pro Phe Thr 1 5 < 210 > 236 < 211 > 261 < 212 > PRT < 213 > Unknown < 220 > < 223 > Description of Unknown : Claudin - 18 . 2 polypeptide < 400 > 236 Met Ala Val Thr Ala Cys Gln Gly Leu Gly Phe Val Val Ser Leu Ile 1 5 10 15 Gly Ile Ala Gly Ile Ile Ala Ala Thr Cys Met Asp Gln Trp Ser Thr 20 25 30 Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly 35 40 45 Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg 50 55 60 Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 65 70 75 80 Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 85 90 95 Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 100 105 110 Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 115 120 125 Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 130 135 140 Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 145 150 155 160 Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 165 170 175 Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 180 185 190 Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 195 200 205 Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 210 215 220 Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 225 230 235 240 Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 245 250 255 Lys His Asp Tyr Val 260