그러 한 치료 모이 어 티 를 컨 쥬 게이팅 하 기 위한 기술 은 잘 알려져 있 고 , 본 발명 의 분자 에 적용 될 수 있 다 . 예 를 들 어 , 문헌 [ Arnon et al . ," "" Monoclonal Antibodies For Immunotargeting Of Drugs In Cancer Therapy """, in Monoclonal Antibodies And Cancer Therapy , Reisfeld et al . ( eds . ) , pp . 243 - 56 ( Alan R . Liss , Inc . 1985 ) ] ; [ Hellstrom et al . ," "" Antibodies For Drug Delivery """, in Controlled Drug Delivery ( 2 nd Ed . ) , Robinson et al . ( eds . ) , pp . 623 - 53 ( Marcel Dekker , Inc . 1987 ) ] ; [ Thorpe , " "" Antibody Carriers Of Cytotoxic Agents In Cancer Therapy : A Review """, in Monoclonal Antibodies ' 84 : Biological And Clinical Applications , Pinchera et al . ( eds . ) , " pp . 475 - 506 ( 1985 ) ] ; [ "" Analysis ", Results , " And Future Prospective Of The Therapeutic Use Of Radiolabeled Antibody In Cancer Therapy """, in Monoclonal Antibodies For Cancer Detection And Therapy , Baldwin et al . ( eds . ) , pp . 303 - 16 ( Academic Press 1985 ) ] 및 [ Thorpe et al . ," "" The Preparation And Cytotoxic Properties Of Antibody - Toxin Conjugates """, Immunol . Rev . , 62 : 119 - 58 ( 1982 ) ] 을 참조 한다 .