화합물 188 - E 2 LC / MS ESI 507 . 2 ( M + H ) +. 1 H NMR ( 500 MHz , MeOD ) δ 7 . 33 ( dd , J = 14 . 6 , 7 . 7 Hz , 2 H ) , 7 . 08 ( d , J = 4 . 7 Hz , 1 H ) , 7 . 03 ( d , J = 8 . 3 Hz , 1 H ) , 6 . 92 ( t , J = 7 . 5 Hz , 1 H ) , 6 . 33 ( d , J = 6 . 1 Hz , 1 H ) , 5 . 09 ( s , 1 H ) , 4 . 72 ? 4 . 67 ( m , 1 H ) , 4 . 39 ? 4 . 07 ( m , 3 H ) , 3 . 90 ? 3 . 43 ( m , 4 H ) , 3 . 34 - 3 . 26 ( m , 3 H ) , 2 . 98 ? 2 . 90 ( m , 1 H ) , 2 . 64 ( t , J = 6 . 1 Hz , 2 H ) , 2 . 49 ( d , J = 5 . 9 Hz , 2 H ) , 2 . 11 ( d , J = 39 . 5 Hz , 2 H ) , 1 . 82 ( s , 2 H ) , 1 . 73 ? 1 . 65 ( m , 2 H ) , 1 . 53 ( d , J = 38 . 0 Hz , 1 H ) , 1 . 37 ( dd , J = 16 . 7 , 6 . 0 Hz , 6 H ) . 키 랄 SFC F ( 40 % EtOH ) : ee 96 %, Rt = 11 . 57 분