You ' ve Got Mail followed by a flurry of statuses on AIM . <| sep |> Pretty much , rush either wows everyones pants off or feeds his own off . <| sep |> I ' m colorblind and I probably have the same phones . I can differentiate the shades if I look carefully enough , but I ' ll end up looking at the light for a solid second before being sure of myself , rather than it being painfully obvious at a glance . I wish they had used red and blue or something . <| sep |> cast on cast its real <| sep |> It shouldn ' t work in 1 . 9 , it used server time now <| sep |> 12 team standard . Crowder vs DAL or Martin vs SEA ? ? Thanks ! <| sep |> Chronic pain , Depression , anxiety , and other traumadriven mental and mood disorders . I can only speak to it ' s mechanism of action for trauma based mood disorders . What trauma based means is that the targeted disease is caused by trauma in early to late brain development . The trauma doesn ' t have to be as severe as battlefield trauma , sexual , physical , or emotional abuse , abandonment , etc . although it does work for these cases as well . It ' s any stressor that raises brain cortisol levels . For me , it was a highly stressful childhood home life , and my first symptoms of anxietydepression appeared around 8 years old . These stressors raise brain cortisol levelsRaised brain cortisol levels in the mood centers of the brain can inhibit BDNF , which is a hormone that promotes the growth of synapses and dendrites . Essentially , childhood stressors raise local brain cortisol levels , which in turn inhibits BDNF production , which in turn inhibits growth of mood centers . Essentially , the mood center is stunted . It ' s not malformed , it ' s just not robust enough . Ketamine triggers BDNF production in the mood center , which in young adults and adolescents and I think children stimulates synapse and dendrite growth , which repairs and rebuilds stunted mood regulation centers . What it doesn ' t work for is depression anxiety that comes on later in life due to circumstances death of a loved one , breakup , loss of job that happen AFTER brain development , or any mood disorder that ' s NOT rooted in a stunted mood center . Phobic anxiety due to a trauma that happened after brain development is similarly always not treated by ketamine , nor are personality disorders . Luckily , these conditions are well treated by traditional SSRI ' s , CBT , DBT , etc . BUT an overwhelming amount of people with mood disorders that are treatment resistant have their disorders rooted in a stunted mood center in the brain . SSRI ' s , MAOI ' s , and other antianxiety and depression meds do not work , or don ' t work as well as they could , for the treatment resistant depression . For me , SSRI ' s , MAOI ' s , Tricyclics , Lithium , Benzos , and many others had little to no affect on my anxiety or my depression . I could take a high dose of Xanax and feel zilch . In my case , this is also due to genetic resistance to many medications , both psychotropic and not most painkillers do not work on me , adhd meds , etc , but that is only another complication , and is generally atypical . The main issue in my case , and the case of many other treatment resistant people , wasn ' t a hormonal deficiency , what is treated by traditional antidepressants , it was literally stunted brain growth . It basically cured my depression , and really helped my anxiety . TLDR Ketamine infusions treat treatment resistant depression by stimulating the growth of mood centers affected by trauma . It doesn ' t work on personality disorders , or mood disorders caused by environmental factors that appeared late in life . I ' m just going off what I read in the literature and what my doctor told me , so I could have some of the more technical details wrong , but that ' s the general concept . Feel free to ask any more questions , be they personal or technical .