" 이러 한 인식 은 CD 137 에 대해 면역 특이 적 인 항체 가 면역 체계 를 활성 화 하 기 위해 사용 될 수 있 고 그 로써 암 에 대한 치료법 을 제공 할 수 있 을 것 이 라는 개념 으로 이어졌 다 ( Melero I . et al . ( 1997 ) "" Monoclonal Antibodies Against The 4 - 1 BB T - Cell Activation Molecule Eradicate Established Tumors """, Nat Med . 3 : 682 - 385 ; Sun , " Y . et al . ( 2002 ) "" Costimulatory Molecule - Targeted Antibody Therapy Of A Spontaneous Autoimmune Disease """, Nature Med . 8 : 1405 - 1413 ; Kammer , " G . M . et al . ( 2002 ) "" Immunotherapy Tackles Lupus """, Nat . Med . 8 ( 12 ) : 1356 - 1358 ; Foell , " J . et al . ( 2003 ) "" CD 137 Costimulatory T Cell Receptor Engagement Reverses Acute Disease In Lupus - Prone NZB x NZW F 1 Mice """, J . Clin . Invest . 111 ( 10 ) : 1505 - 1518 ; Mittler , " R . S . et al . ( 2004 ) "" Anti - CD 137 Antibodies In The Treatment Of Autoimmune Disease And Cancer """, Immunol . Res . 29 ( 1 - 3 ) : 197 - 208 ; Foell , " J . L . et al . ( 2004 ) "" Engagement of The CD 137 ( 4 - 1 BB ) Costimulatory Molecule Inhibits And Reverses The Autoimmune Process In Collagen - Induced Arthritis And Establishes Lasting Disease Resistance """, Immunology 113 ( 1 ) : 89 - 98 ; Sytwu , " H . K . et al . ( 2003 ) "" Anti - 4 - 1 BB - Based Immunotherapy For Autoimmune Diabetes : Lessons From A Transgenic Non - Obese Diabetic ( NOD ) Model """," J . Autoimmun . 21 ( 3 ) : 247 - 254 ; Hernandez - Chacon JA et al . ( 2011 ) "" Costimulation Through The CD 137 / 4 - 1 BB Pathway Protects Human Melanoma Tumor - Infiltrating Lymphocytes From Activation Induced Cell Death And Enhances Antitumor Effector Function """, J . Immunother . 34 : 236 - 250 ; Morales - Kastresana , " A . et al . ( 2014 ) "" Combinations Of Immunostimulatory Antibodies With Synergistic Effects Against Spontaneous Cancer """, OncoImmunology 3 : 2 , e 27812 , pp . 1 - 4 ; Sanmamed , " M . F . et al . ( 2015 ) "" Agonists of Co - stimulation in Cancer Immunotherapy Directed Against CD 137 ", OX 40 , GITR , CD 27 , CD 28 , " and ICOS """, Seminars Oncol . 42 ( 4 ) : 640 - 655 ; Tongu , " M . et al . ( 2015 ) "" Intermittent Chemotherapy Can Retain The Therapeutic Potential Of Anti - CD 137 Antibody During The Late Tumor - 포함 State """, Cancer Sci . 106 ( 1 ) : 9 - 17 ; Takeda , " K . et al . ( 2007 ) "" Combination Antibody - Based Cancer Immunotherapy """, Cancer Sci . 98 ( 9 ) : 1297 - 1302 ) . 항 - CD 137 항체 는 미국 특허 번호 2014 / 0274909 ; 2013 / 0280265 ; 2013 / 0273078 ; 2013 / 0071403 ; 2012 / 0058047 ; 2011 / 0104049 ; 2011 / 0097313 ; 2008 / 0166336 ; 2008 / 0019905 ; 2006 / 0188439 ; 2006 / 0182744 ; 2006 / 0121030 ; 및 2003 / 0223989 에서 개시 된다 .