Gently . Jokes aside . I would remove the graphics card and HDDs to pack separately . The PCIe slot will not like the potential flexing as the rig gets bumped about , and HDD platters certainly do not benefit from crashing into the read head . SSDs don ' t really care since they have no moving parts to speak of , and the CPU cooler is a tad too inconvenient to remove just for transporting . Rest the rig on its side , motherboard facing up throughout , since the CPU cooler would be stuck there , especially if it is an air cooler . You certainly don ' t want the air cooler to shear off the board . AIOs are not as big of a worry since the water block is not as bulky as an air cooler and the radiator is secured onto the case . RAM sticks are very light , so that is not a huge concern . Try finding some padding material to stuff the inside to help soak up any bumps along the way . Just remember to plug in the graphics card and HDDs back in after you reach your destination . That ' s about all I can think of for now .