Why was Ceci in that position and ignoring the rest of the Bruins behind him ? I swear his hockey awareness sometimes is worse than mine . <| sep |> FUCKING TACKLE . WHY ARE WE TRYING TO STRIP <| sep |> And that is how we do that <| sep |> Wasn ' t Stein basically fighting for Donald at the end of the election ? Wtf with the sudden turn ? <| sep |> Queen has been around since the late 60 s <| sep |> User Deleted Comment 0 . 5316 U 8 ZOh 2 OLOEQ <| sep |> I wonder what the grey car did to set the other motorist off . <| sep |> Thank you for covering a gap in my knowledge with regards to SNARE proteins ! So from what I see , exocytosis is still calcium dependent which is still why I contend that there is a concentration gradient . I don ' t have evidence since this question hasn ' t explicitly been addressed in the manner that I propose , but rather my theory relies on that necessity of calcium in the pre relative to the post synapse . Surely with your experience you understand that postsynaptic calcium influx causes restructuring of the dendritic spine via PKM proteins and CaMKII . As a spine matures , postsynaptic AMPAR are first calcium permeable GluA 2 and then replaced with calcium impermeable receptors GluA 1 . If calcium was constitutively present in the postsynaptic dendrite than there would be constant restructuring and it would contribute to degradation of the matured spine in the absence of constant stimulation . So my point is that higher intracellular presynaptic calcium concentrations are more metabolocally advantageous due to the necessity for exocytosis than postsynaptic calcium concentrations where calcium is scarce lest there be constant dendritic reorganization